DERL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.09054317
2COPI coating of Golgi vesicle (GO:0048205)9.09054317
3intestinal cholesterol absorption (GO:0030299)7.89074886
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)7.63551169
5positive regulation of respiratory burst (GO:0060267)7.40766026
6positive regulation of nuclease activity (GO:0032075)7.36543611
7regulation of nuclease activity (GO:0032069)6.88770873
8digestion (GO:0007586)6.70699337
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.66775082
10* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)6.50918727
11* endoplasmic reticulum unfolded protein response (GO:0030968)6.34535674
12* response to endoplasmic reticulum stress (GO:0034976)6.29472196
13proline biosynthetic process (GO:0006561)6.27095533
14COPII vesicle coating (GO:0048208)6.22302169
15* cellular response to unfolded protein (GO:0034620)6.18742627
16negative regulation of glucose import (GO:0046325)5.95361697
17* cellular response to topologically incorrect protein (GO:0035967)5.94772731
18complement activation, classical pathway (GO:0006958)5.86370449
19* ER-nucleus signaling pathway (GO:0006984)5.75650588
20intestinal epithelial cell development (GO:0060576)5.75500909
21regulation of respiratory burst (GO:0060263)5.46753406
22* protein N-linked glycosylation via asparagine (GO:0018279)5.44280153
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.43706666
24* peptidyl-asparagine modification (GO:0018196)5.40566842
25GDP-mannose metabolic process (GO:0019673)5.38690734
26cell redox homeostasis (GO:0045454)5.26346523
27protein maturation by protein folding (GO:0022417)5.19706737
28* response to unfolded protein (GO:0006986)5.08852371
29* protein N-linked glycosylation (GO:0006487)4.97491360
30glomerular filtration (GO:0003094)4.96060730
31regulation of glucose import in response to insulin stimulus (GO:2001273)4.94002075
32* response to topologically incorrect protein (GO:0035966)4.91901127
33ER overload response (GO:0006983)4.83938259
34transcytosis (GO:0045056)4.71223559
35apoptotic cell clearance (GO:0043277)4.66671020
36positive regulation of growth hormone secretion (GO:0060124)4.61928460
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.58897487
38immunoglobulin mediated immune response (GO:0016064)4.57573690
39valine metabolic process (GO:0006573)4.57408761
40mitochondrial calcium ion transport (GO:0006851)4.53129798
41negative regulation of glucose transport (GO:0010829)4.46360854
42UDP-N-acetylglucosamine metabolic process (GO:0006047)4.46022807
43regulation of dendritic cell antigen processing and presentation (GO:0002604)4.44251921
44complement activation (GO:0006956)4.41425497
45maintenance of protein localization in organelle (GO:0072595)4.39399519
46proline metabolic process (GO:0006560)4.33195489
47positive regulation of gamma-delta T cell activation (GO:0046645)4.31698049
48zinc ion transport (GO:0006829)4.31292010
49renal filtration (GO:0097205)4.27080103
50sequestering of metal ion (GO:0051238)4.25417583
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.21949919
52regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.21506999
53antibacterial humoral response (GO:0019731)4.17156928
54branched-chain amino acid catabolic process (GO:0009083)4.16802001
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15562207
56positive regulation of antigen processing and presentation (GO:0002579)4.15051322
57regulation of antigen processing and presentation (GO:0002577)4.13389480
58regulation of phospholipase A2 activity (GO:0032429)4.10884825
59humoral immune response (GO:0006959)4.10287582
60antimicrobial humoral response (GO:0019730)4.08284133
61protein activation cascade (GO:0072376)4.07234465
624-hydroxyproline metabolic process (GO:0019471)3.99873030
63detection of bacterium (GO:0016045)3.99580822
64peptidyl-proline hydroxylation (GO:0019511)3.99429628
65intestinal absorption (GO:0050892)3.94842751
66vesicle coating (GO:0006901)3.88548492
67cysteine metabolic process (GO:0006534)3.86924607
68mature B cell differentiation involved in immune response (GO:0002313)3.80370048
69branched-chain amino acid metabolic process (GO:0009081)3.78719473
70cellular response to antibiotic (GO:0071236)3.74952772
71detection of other organism (GO:0098543)3.72249495
72cobalamin metabolic process (GO:0009235)3.69987252
73glycolipid catabolic process (GO:0019377)3.69077892
74regulation of cellular extravasation (GO:0002691)3.69001580
75epithelial cell maturation (GO:0002070)3.68758594
76positive regulation of B cell differentiation (GO:0045579)3.63330994
77B cell mediated immunity (GO:0019724)3.61643087
78L-fucose catabolic process (GO:0042355)3.60478188
79fucose catabolic process (GO:0019317)3.60478188
80L-fucose metabolic process (GO:0042354)3.60478188
81muscle organ morphogenesis (GO:0048644)3.60337783
82immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.57211419
83Fc-gamma receptor signaling pathway (GO:0038094)3.57211419
84Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.57211419
85B cell receptor signaling pathway (GO:0050853)3.56719285
86Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.55132823
87interferon-gamma-mediated signaling pathway (GO:0060333)3.49521639
88response to type I interferon (GO:0034340)3.45255932
89membrane lipid catabolic process (GO:0046466)3.43301957
90negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.43296533
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42778469
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42778469
93cellular response to type I interferon (GO:0071357)3.42761574
94type I interferon signaling pathway (GO:0060337)3.42761574
95defense response to protozoan (GO:0042832)3.42640868
96ER to Golgi vesicle-mediated transport (GO:0006888)3.39916517
97sterol catabolic process (GO:0016127)3.39856989
98cholesterol catabolic process (GO:0006707)3.39856989
99antigen processing and presentation of endogenous antigen (GO:0019883)3.39278402
100galactose catabolic process (GO:0019388)3.35090531
101nucleotide-sugar metabolic process (GO:0009225)3.34005884
102cellular response to ATP (GO:0071318)3.31740247
103nucleoside diphosphate catabolic process (GO:0009134)3.31427804
104negative regulation of digestive system process (GO:0060457)3.30206733
105cellular modified amino acid catabolic process (GO:0042219)3.28137150
106Peyers patch development (GO:0048541)3.28081977
107mucosal-associated lymphoid tissue development (GO:0048537)3.28081977
108serine family amino acid biosynthetic process (GO:0009070)3.24968197
109NIK/NF-kappaB signaling (GO:0038061)3.24880190
110nucleotide-sugar biosynthetic process (GO:0009226)3.21443595
111regulation of growth hormone secretion (GO:0060123)3.14404525
112regulation of gamma-delta T cell activation (GO:0046643)3.13390006
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12413021
114chaperone-mediated protein folding (GO:0061077)3.10845811
115Golgi organization (GO:0007030)3.10602497
116regulation of gamma-delta T cell differentiation (GO:0045586)3.08654915
117fucose metabolic process (GO:0006004)3.08476625
118negative regulation of cell killing (GO:0031342)3.08364552
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08364552
120protein hydroxylation (GO:0018126)3.08147225
121monoamine transport (GO:0015844)3.07465015
122protein targeting to ER (GO:0045047)3.07096821
123maternal placenta development (GO:0001893)3.07006627
124mannose metabolic process (GO:0006013)3.06480811
125positive thymic T cell selection (GO:0045059)3.06115033
126L-serine metabolic process (GO:0006563)3.05934514
127cotranslational protein targeting to membrane (GO:0006613)3.03963886
128tolerance induction (GO:0002507)3.02330471
129mature B cell differentiation (GO:0002335)3.02108619
130germinal center formation (GO:0002467)3.00595988
131response to interferon-beta (GO:0035456)2.99327806
132response to protozoan (GO:0001562)2.97427570
133protein folding (GO:0006457)2.95121236
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94927570
135protein localization to endoplasmic reticulum (GO:0070972)2.92591846
136ceramide catabolic process (GO:0046514)2.92422729
137respiratory burst (GO:0045730)2.89843108
138endocrine pancreas development (GO:0031018)2.88787246
139regulation of B cell differentiation (GO:0045577)2.87849986
140immune response-activating cell surface receptor signaling pathway (GO:0002429)2.87225439
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87175650
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.86342283
143negative regulation of glycogen biosynthetic process (GO:0045719)2.84470758
144cellular response to interferon-gamma (GO:0071346)2.84262776
145purine deoxyribonucleotide catabolic process (GO:0009155)2.83631414
146deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82363463
147retina homeostasis (GO:0001895)2.79207207
148glutamine metabolic process (GO:0006541)2.77892490
149cellular response to interferon-beta (GO:0035458)2.77286985
150negative regulation of B cell apoptotic process (GO:0002903)2.74503049
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72979631
152CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72456862
153myeloid dendritic cell activation (GO:0001773)2.70908204
154response to interferon-gamma (GO:0034341)2.67624834
155DNA strand elongation involved in DNA replication (GO:0006271)2.66915357
156angiotensin maturation (GO:0002003)2.66622152
157Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64764623
158antigen processing and presentation via MHC class Ib (GO:0002475)2.63048407
159T cell costimulation (GO:0031295)2.62840361
160dendritic cell chemotaxis (GO:0002407)2.62260115
161negative regulation of phagocytosis (GO:0050765)2.61877771
162regulation of guanylate cyclase activity (GO:0031282)2.61754861
163lymphocyte costimulation (GO:0031294)2.59333692
164regulation of B cell receptor signaling pathway (GO:0050855)2.59098065
165production of molecular mediator of immune response (GO:0002440)2.56865515
166cellular response to virus (GO:0098586)2.54611934
167detection of external biotic stimulus (GO:0098581)2.52952984
168DNA strand elongation (GO:0022616)2.52330372
169thymic T cell selection (GO:0045061)2.51208718
170pyrimidine nucleoside salvage (GO:0043097)2.49588940
171pyrimidine-containing compound salvage (GO:0008655)2.49588940
172regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47635550
173deoxyribonucleotide catabolic process (GO:0009264)2.45467350
174B cell homeostasis (GO:0001782)2.42237345
175positive regulation of neutrophil migration (GO:1902624)2.42179050
176positive regulation of neutrophil chemotaxis (GO:0090023)2.42179050
177chaperone mediated protein folding requiring cofactor (GO:0051085)2.42009648
178regulation of necrotic cell death (GO:0010939)2.41224980
179positive regulation by symbiont of host defense response (GO:0052509)2.41176939
180modulation by symbiont of host defense response (GO:0052031)2.41176939
181modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41176939
182modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41176939
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.41176939
184modulation by symbiont of host immune response (GO:0052553)2.41176939
185pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40922950
186negative regulation of innate immune response (GO:0045824)2.40265036
187positive regulation of pseudopodium assembly (GO:0031274)2.38867790
188exocrine pancreas development (GO:0031017)12.8004526
189maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.0730993
190protein retention in ER lumen (GO:0006621)10.5842538
191signal peptide processing (GO:0006465)10.3776820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.59286749
2E2F7_22180533_ChIP-Seq_HELA_Human4.63108790
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90978021
4VDR_21846776_ChIP-Seq_THP-1_Human3.59510093
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.46755935
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36062447
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.33015868
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69672582
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55436983
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46513974
11VDR_24763502_ChIP-Seq_THP-1_Human2.38136676
12* LXR_22292898_ChIP-Seq_THP-1_Human2.35698027
13MYC_22102868_ChIP-Seq_BL_Human2.34843025
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32909714
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29054157
16* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28697577
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27668264
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27668264
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27668264
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.12534168
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11785832
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11526095
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08561427
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08240599
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.05443047
26MAF_26560356_Chip-Seq_TH1_Human2.05288284
27UTX_26944678_Chip-Seq_JUKART_Human2.02791263
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02369733
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93838479
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87189988
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.84467019
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.83934423
33BCL6_27268052_Chip-Seq_Bcells_Human1.83496965
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81419158
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.80137958
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77082631
37MAF_26560356_Chip-Seq_TH2_Human1.76997116
38SCL_19346495_ChIP-Seq_HPC-7_Human1.76112868
39BCOR_27268052_Chip-Seq_Bcells_Human1.71571157
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.71503483
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71386229
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68519587
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66666820
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63947985
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63650732
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63475125
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63096544
48KDM5A_27292631_Chip-Seq_BREAST_Human1.62927368
49* SPI1_23547873_ChIP-Seq_NB4_Human1.62793475
50* P68_20966046_ChIP-Seq_HELA_Human1.62102514
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61148895
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59305036
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58302220
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57469803
55* LXR_22158963_ChIP-Seq_LIVER_Mouse1.57050222
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56443878
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55650499
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.51671859
59TCF7_22412390_ChIP-Seq_EML_Mouse1.51458804
60GABP_19822575_ChIP-Seq_HepG2_Human1.46080461
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.45816317
62DCP1A_22483619_ChIP-Seq_HELA_Human1.44910097
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.44821309
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44283974
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41407052
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41207844
67KDM2B_26808549_Chip-Seq_DND41_Human1.41167001
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40757238
69NCOR1_26117541_ChIP-Seq_K562_Human1.38361397
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36931782
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35895910
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.35792219
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35148357
74GATA6_25053715_ChIP-Seq_YYC3_Human1.34325328
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34296947
76E2F1_20622854_ChIP-Seq_HELA_Human1.33679467
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.33096689
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32489635
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32435170
80* CHD1_26751641_Chip-Seq_LNCaP_Human1.32289207
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31253186
82RACK7_27058665_Chip-Seq_MCF-7_Human1.30700955
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30043605
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29680179
85GATA4_25053715_ChIP-Seq_YYC3_Human1.29407182
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27723212
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26471958
88PHF8_20622854_ChIP-Seq_HELA_Human1.26385087
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26137780
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25486935
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25328374
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.25209301
93SMC4_20622854_ChIP-Seq_HELA_Human1.24580711
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23961095
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23328198
96* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23024771
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23006433
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22534573
99P300_27268052_Chip-Seq_Bcells_Human1.22459149
100SA1_27219007_Chip-Seq_Bcells_Human1.22434056
101* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22368420
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.21047187
103* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20580674
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.20477948
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20294298
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20048466
107VDR_23849224_ChIP-Seq_CD4+_Human1.19717299
108CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19713070
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18744984
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18698580
111* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18447036
112* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16923751
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16602642
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16558081
115* YY1_22570637_ChIP-Seq_MALME-3M_Human1.16387608
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15807671
117SRF_21415370_ChIP-Seq_HL-1_Mouse1.15639868
118* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15175770
119CTCF_21964334_Chip-Seq_Bcells_Human1.15129727
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13576642
121SPI1_23127762_ChIP-Seq_K562_Human1.13216853
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13214124
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12459740
124ERG_20517297_ChIP-Seq_VCAP_Human1.10066090
125GATA1_19941826_ChIP-Seq_K562_Human1.09223491
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09056328
127ZNF274_21170338_ChIP-Seq_K562_Hela1.08066336
128CLOCK_20551151_ChIP-Seq_293T_Human1.07842758
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06871489
130EGR1_19374776_ChIP-ChIP_THP-1_Human1.05459249
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05189470
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04287129
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04208995
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03567855
135P53_21459846_ChIP-Seq_SAOS-2_Human1.02979022
136SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02157112
137CIITA_25753668_ChIP-Seq_RAJI_Human1.01745696
138MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01654441
139MYB_26560356_Chip-Seq_TH2_Human1.01020895
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00529516
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99494134
142FOXP3_21729870_ChIP-Seq_TREG_Human0.99487030
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99217709
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98984679
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98647836
146STAT1_20625510_ChIP-Seq_HELA_Human0.98286969
147GATA1_22025678_ChIP-Seq_K562_Human0.97976619
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97265320
149MYB_26560356_Chip-Seq_TH1_Human0.96866207
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96824414
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96096581
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.96092477
153TFEB_21752829_ChIP-Seq_HELA_Human0.96072945
154STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95866583
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.95315419
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95129976
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94984960
158CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94462291
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.94343443
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94319866
161MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94028219
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93705634
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.93560054
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92590201
165CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91428921
166RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91276801
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.90005526
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89490891
169ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88469868
170GATA3_26560356_Chip-Seq_TH1_Human0.88216522
171RUNX_20019798_ChIP-Seq_JUKART_Human0.87699536
172* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87200829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption6.61874082
2MP0005220_abnormal_exocrine_pancreas6.10132962
3MP0005083_abnormal_biliary_tract5.69981332
4MP0005365_abnormal_bile_salt5.08646840
5MP0004264_abnormal_extraembryonic_tissu4.77284814
6MP0010234_abnormal_vibrissa_follicle3.89624420
7MP0002693_abnormal_pancreas_physiology3.50764359
8MP0000685_abnormal_immune_system3.19571860
9MP0003868_abnormal_feces_composition3.15150534
10MP0003724_increased_susceptibility_to2.92699038
11MP0001944_abnormal_pancreas_morphology2.86213714
12MP0005025_abnormal_response_to2.72006123
13MP0002139_abnormal_hepatobiliary_system2.54157379
14MP0005084_abnormal_gallbladder_morpholo2.50533739
15MP0005085_abnormal_gallbladder_physiolo2.42915078
16MP0003693_abnormal_embryo_hatching2.18816599
17MP0005310_abnormal_salivary_gland2.14164027
18MP0002148_abnormal_hypersensitivity_rea2.11949016
19MP0002396_abnormal_hematopoietic_system2.11297082
20MP0009278_abnormal_bone_marrow2.09512548
21MP0009785_altered_susceptibility_to2.06308165
22MP0002419_abnormal_innate_immunity2.04193170
23MP0000613_abnormal_salivary_gland2.03010714
24MP0002398_abnormal_bone_marrow2.00052983
25MP0004043_abnormal_pH_regulation1.99415628
26MP0003195_calcinosis1.96790093
27MP0002138_abnormal_hepatobiliary_system1.92010381
28MP0001835_abnormal_antigen_presentation1.73628032
29MP0000465_gastrointestinal_hemorrhage1.72740037
30MP0001664_abnormal_digestion1.67433682
31MP0002429_abnormal_blood_cell1.65584822
32MP0002722_abnormal_immune_system1.65033881
33MP0005451_abnormal_body_composition1.63104748
34MP0009643_abnormal_urine_homeostasis1.61897940
35MP0003959_abnormal_lean_body1.56797056
36MP0004233_abnormal_muscle_weight1.52080982
37MP0005464_abnormal_platelet_physiology1.50398232
38MP0010386_abnormal_urinary_bladder1.50300321
39MP0005166_decreased_susceptibility_to1.50043117
40MP0000003_abnormal_adipose_tissue1.48476058
41MP0003183_abnormal_peptide_metabolism1.47470992
42MP0005332_abnormal_amino_acid1.46316953
43MP0002405_respiratory_system_inflammati1.44726110
44MP0004947_skin_inflammation1.44371189
45MP0001873_stomach_inflammation1.43813040
46MP0005058_abnormal_lysosome_morphology1.40221672
47MP0009379_abnormal_foot_pigmentation1.38970005
48MP0004858_abnormal_nervous_system1.38275631
49MP0003300_gastrointestinal_ulcer1.36584189
50MP0002078_abnormal_glucose_homeostasis1.35671711
51MP0001533_abnormal_skeleton_physiology1.35605132
52MP0004782_abnormal_surfactant_physiolog1.31762023
53MP0006082_CNS_inflammation1.31127125
54MP0005397_hematopoietic_system_phenotyp1.30963738
55MP0001545_abnormal_hematopoietic_system1.30963738
56MP0000703_abnormal_thymus_morphology1.30626382
57MP0000490_abnormal_crypts_of1.29561008
58MP0005647_abnormal_sex_gland1.21907647
59MP0000477_abnormal_intestine_morphology1.21735541
60MP0003111_abnormal_nucleus_morphology1.19294191
61MP0005636_abnormal_mineral_homeostasis1.16337443
62MP0006054_spinal_hemorrhage1.16263312
63MP0001800_abnormal_humoral_immune1.16138512
64MP0001845_abnormal_inflammatory_respons1.15081402
65MP0001765_abnormal_ion_homeostasis1.14917580
66MP0002166_altered_tumor_susceptibility1.14536483
67MP0000858_altered_metastatic_potential1.12960446
68MP0003186_abnormal_redox_activity1.10779366
69MP0005387_immune_system_phenotype1.09504763
70MP0001790_abnormal_immune_system1.09504763
71MP0010094_abnormal_chromosome_stability1.07555989
72MP0001764_abnormal_homeostasis1.07360000
73MP0005671_abnormal_response_to1.06908654
74MP0009840_abnormal_foam_cell1.04633929
75MP0005408_hypopigmentation1.03021675
76MP0002118_abnormal_lipid_homeostasis1.02479055
77MP0009765_abnormal_xenobiotic_induced1.02122167
78MP0000609_abnormal_liver_physiology1.01221778
79MP0003638_abnormal_response/metabolism_0.99620940
80MP0008260_abnormal_autophagy0.98310701
81MP0002877_abnormal_melanocyte_morpholog0.97488562
82MP0002132_abnormal_respiratory_system0.97151881
83MP0009764_decreased_sensitivity_to0.97043355
84MP0002933_joint_inflammation0.95068998
85MP0010352_gastrointestinal_tract_polyps0.92924246
86MP0000470_abnormal_stomach_morphology0.92897147
87MP0002277_abnormal_respiratory_mucosa0.91876178
88MP0001986_abnormal_taste_sensitivity0.90481054
89MP0008004_abnormal_stomach_pH0.89798064
90MP0004957_abnormal_blastocyst_morpholog0.88149063
91MP0010307_abnormal_tumor_latency0.87960610
92MP0001919_abnormal_reproductive_system0.87832131
93MP0010155_abnormal_intestine_physiology0.85508951
94MP0005319_abnormal_enzyme/_coenzyme0.84735098
95MP0000681_abnormal_thyroid_gland0.83978771
96MP0000313_abnormal_cell_death0.83516505
97MP0003953_abnormal_hormone_level0.83344280
98MP0010329_abnormal_lipoprotein_level0.82947956
99MP0005448_abnormal_energy_balance0.81463918
100MP0002796_impaired_skin_barrier0.80881170
101MP0003763_abnormal_thymus_physiology0.80760746
102MP0000639_abnormal_adrenal_gland0.79939747
103MP0003077_abnormal_cell_cycle0.78956335
104MP0003448_altered_tumor_morphology0.78456844
105MP0002452_abnormal_antigen_presenting0.78086088
106MP0003806_abnormal_nucleotide_metabolis0.76578226
107MP0003075_altered_response_to0.75725836
108MP0005075_abnormal_melanosome_morpholog0.74744918
109MP0003656_abnormal_erythrocyte_physiolo0.74736691
110MP0002723_abnormal_immune_serum0.74731976
111MP0003795_abnormal_bone_structure0.74593951
112MP0002006_tumorigenesis0.74279083
113MP0002909_abnormal_adrenal_gland0.72926013
114MP0000598_abnormal_liver_morphology0.71647125
115MP0004147_increased_porphyrin_level0.71597494
116MP0003252_abnormal_bile_duct0.71301938
117MP0008057_abnormal_DNA_replication0.70154368
118MP0001663_abnormal_digestive_system0.69743375
119MP0009333_abnormal_splenocyte_physiolog0.68781649
120MP0009763_increased_sensitivity_to0.68429026
121MP0001756_abnormal_urination0.67144998
122MP0001879_abnormal_lymphatic_vessel0.66584088
123MP0002420_abnormal_adaptive_immunity0.66269748
124MP0005381_digestive/alimentary_phenotyp0.65692463
125MP0003453_abnormal_keratinocyte_physiol0.65280067
126MP0001853_heart_inflammation0.64016102
127MP0005390_skeleton_phenotype0.63871382
128MP0006036_abnormal_mitochondrial_physio0.63088892
129MP0002998_abnormal_bone_remodeling0.62708290
130MP0000689_abnormal_spleen_morphology0.62327455
131MP0005379_endocrine/exocrine_gland_phen0.61287239
132MP0005389_reproductive_system_phenotype0.61237835
133MP0001819_abnormal_immune_cell0.60583477
134MP0005165_increased_susceptibility_to0.60496310
135MP0002136_abnormal_kidney_physiology0.60204475
136MP0009780_abnormal_chondrocyte_physiolo0.59956395
137MP0005360_urolithiasis0.59945446
138MP0002653_abnormal_ependyma_morphology0.59221429
139MP0003866_abnormal_defecation0.58362990
140MP0005535_abnormal_body_temperature0.57161783
141MP0000678_abnormal_parathyroid_gland0.56329835
142MP0002928_abnormal_bile_duct0.55858005
143MP0003436_decreased_susceptibility_to0.55664572
144MP0005000_abnormal_immune_tolerance0.54892743
145MP0000013_abnormal_adipose_tissue0.54854551
146MP0002098_abnormal_vibrissa_morphology0.54377866
147MP0005076_abnormal_cell_differentiation0.54178760
148MP0009642_abnormal_blood_homeostasis0.54032411
149MP0002896_abnormal_bone_mineralization0.53073754
150MP0008469_abnormal_protein_level0.52903273
151MP0000716_abnormal_immune_system0.51883700
152MP0003303_peritoneal_inflammation0.50190670
153MP0002019_abnormal_tumor_incidence0.50083599

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.15679635
2Abnormality of B cell number (HP:0010975)5.13653912
3B lymphocytopenia (HP:0010976)5.13653912
4Onycholysis (HP:0001806)5.01885797
5Abnormality of the intrinsic pathway (HP:0010989)4.63241509
6Colitis (HP:0002583)4.47505162
7Steatorrhea (HP:0002570)4.22400169
8Abnormal protein glycosylation (HP:0012346)4.21712589
9Abnormal glycosylation (HP:0012345)4.21712589
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.21712589
11Abnormal protein N-linked glycosylation (HP:0012347)4.21712589
12Eczematoid dermatitis (HP:0000976)4.19668630
13Systemic lupus erythematosus (HP:0002725)4.16364676
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.04541618
15Malnutrition (HP:0004395)4.01153221
16Recurrent sinusitis (HP:0011108)4.00688974
17Recurrent bronchitis (HP:0002837)3.94259824
18Hypoplasia of the pons (HP:0012110)3.90573556
19Increased IgE level (HP:0003212)3.84537311
20Autoimmune thrombocytopenia (HP:0001973)3.82611820
21Vacuolated lymphocytes (HP:0001922)3.77598054
22Panhypogammaglobulinemia (HP:0003139)3.73965651
23Fat malabsorption (HP:0002630)3.72315029
24Type I transferrin isoform profile (HP:0003642)3.71752568
25Gout (HP:0001997)3.71325736
26Abnormality of the pons (HP:0007361)3.57915106
27Inflammation of the large intestine (HP:0002037)3.55398935
28Obstructive lung disease (HP:0006536)3.54752572
29Chronic obstructive pulmonary disease (HP:0006510)3.54752572
30Gastrointestinal inflammation (HP:0004386)3.47173228
31Abnormality of subcutaneous fat tissue (HP:0001001)3.44261742
32Abnormality of the nasal mucosa (HP:0000433)3.41723689
33Recurrent bacterial skin infections (HP:0005406)3.37000939
34Vasculitis (HP:0002633)3.34034623
35Mediastinal lymphadenopathy (HP:0100721)3.32941693
36Abnormality of macrophages (HP:0004311)3.32420800
37Nasal polyposis (HP:0100582)3.29858844
38Recurrent abscess formation (HP:0002722)3.28171406
39Elevated erythrocyte sedimentation rate (HP:0003565)3.21074601
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.20305126
41Ketosis (HP:0001946)3.20227317
42Decreased subcutaneous fat (HP:0001002)3.18000678
43Exocrine pancreatic insufficiency (HP:0001738)3.17388607
44Recurrent fungal infections (HP:0002841)3.17309573
45Recurrent viral infections (HP:0004429)3.14590232
46Ketoacidosis (HP:0001993)3.12320773
47Cellulitis (HP:0100658)3.11526675
48IgM deficiency (HP:0002850)3.09452631
49Dry hair (HP:0011359)3.07174501
50Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05284680
51Decreased circulating renin level (HP:0003351)3.03989172
52Chronic otitis media (HP:0000389)3.02998913
53Recurrent lower respiratory tract infections (HP:0002783)3.00519162
54Dysostosis multiplex (HP:0000943)2.98213725
55Abnormality of the prostate (HP:0008775)2.97608109
56Hyperinsulinemic hypoglycemia (HP:0000825)2.97161168
57Progressive muscle weakness (HP:0003323)2.95418775
58Bronchitis (HP:0012387)2.95415118
59Reduced antithrombin III activity (HP:0001976)2.93487061
60Papilloma (HP:0012740)2.93438723
61Verrucae (HP:0200043)2.93438723
62Hypoglycemic coma (HP:0001325)2.91650422
63Emphysema (HP:0002097)2.91011841
64Autoimmune hemolytic anemia (HP:0001890)2.90323412
65Hyperactive renin-angiotensin system (HP:0000841)2.89439788
66Abnormal pancreas size (HP:0012094)2.84936073
67Generalized aminoaciduria (HP:0002909)2.84730677
68Prostate neoplasm (HP:0100787)2.81826307
69Cerebellar dysplasia (HP:0007033)2.80867181
70Villous atrophy (HP:0011473)2.79509688
71Abnormality of small intestinal villus morphology (HP:0011472)2.79509688
72Lymphopenia (HP:0001888)2.78416628
73Abnormality of the common coagulation pathway (HP:0010990)2.76665131
74Recurrent cutaneous fungal infections (HP:0011370)2.75743953
75Chronic mucocutaneous candidiasis (HP:0002728)2.75743953
76Hypoglycemic seizures (HP:0002173)2.73558947
77Type I diabetes mellitus (HP:0100651)2.73055277
78Premature loss of primary teeth (HP:0006323)2.72540291
79Pancreatitis (HP:0001733)2.71519868
80Granulocytopenia (HP:0001913)2.67493713
81Abnormality of T cell physiology (HP:0011840)2.66176045
82Abnormality of the pancreatic islet cells (HP:0006476)2.63177490
83Abnormality of endocrine pancreas physiology (HP:0012093)2.63177490
84Interstitial pulmonary disease (HP:0006530)2.59002828
85Recurrent pneumonia (HP:0006532)2.58475932
86Abnormality of T cells (HP:0002843)2.57581816
87Recurrent gram-negative bacterial infections (HP:0005420)2.57182024
88Joint stiffness (HP:0001387)2.56260167
89Type II lissencephaly (HP:0007260)2.55269158
90Short chin (HP:0000331)2.54398705
91Conical tooth (HP:0000698)2.54126922
92Recurrent skin infections (HP:0001581)2.50394404
93Squamous cell carcinoma (HP:0002860)2.43369810
94Hypergammaglobulinemia (HP:0010702)2.42392635
95Myositis (HP:0100614)2.39754064
96Basal cell carcinoma (HP:0002671)2.38984356
97Vascular calcification (HP:0004934)2.38408921
98Pustule (HP:0200039)2.35310065
99Sepsis (HP:0100806)2.33638218
100Chronic bronchitis (HP:0004469)2.32598629
101Maternal diabetes (HP:0009800)2.32148374
102Abdominal distention (HP:0003270)2.31580960
103Increased IgM level (HP:0003496)2.30357226
104Encephalitis (HP:0002383)2.29608681
105Chronic diarrhea (HP:0002028)2.29025648
106Symptomatic seizures (HP:0011145)2.28387170
107Gastrointestinal stroma tumor (HP:0100723)2.28090421
108Restrictive lung disease (HP:0002091)2.24108640
109Abnormality of sulfur amino acid metabolism (HP:0004339)2.22810474
110Gastrointestinal infarctions (HP:0005244)2.21439745
111Abnormality of incisor morphology (HP:0011063)2.20758841
112Osteomyelitis (HP:0002754)2.19903219
113Abnormality of the fingertips (HP:0001211)2.18997855
114Mucopolysacchariduria (HP:0008155)2.18887894
115Urinary glycosaminoglycan excretion (HP:0003541)2.18887894
116Protuberant abdomen (HP:0001538)2.18449782
117Late onset (HP:0003584)2.17836392
118Dicarboxylic aciduria (HP:0003215)2.17433247
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17433247
120Ridged nail (HP:0001807)2.16225212
121Carpal bone hypoplasia (HP:0001498)2.15940480
122Abnormality of male internal genitalia (HP:0000022)2.15209660
123Hypertensive crisis (HP:0100735)2.14661336
124Abnormality of complement system (HP:0005339)2.14079258
125Recurrent otitis media (HP:0000403)2.13724973
126Glomerulonephritis (HP:0000099)2.12162148
127Gingivitis (HP:0000230)2.11203771
128Lymphoma (HP:0002665)2.10681720
129Cerebral palsy (HP:0100021)2.10532650
130Spontaneous hematomas (HP:0007420)2.09194649
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08815381
132Bronchiectasis (HP:0002110)2.08367265
133Leukocytosis (HP:0001974)2.07949926
134Alkalosis (HP:0001948)2.07141911
135Premature skin wrinkling (HP:0100678)2.07046486
136Petechiae (HP:0000967)2.05537089
137Hemoptysis (HP:0002105)2.04324281
138Cardiovascular calcification (HP:0011915)2.03653031
139Skin ulcer (HP:0200042)2.03569689
140Eosinophilia (HP:0001880)2.01765438
141Limb hypertonia (HP:0002509)2.01619451
142Meningitis (HP:0001287)2.00174281
143Abnormal tarsal ossification (HP:0008369)1.99816969
144Fatigue (HP:0012378)1.99269449
145Urticaria (HP:0001025)1.98908765
146Ileus (HP:0002595)1.98254016
147Ragged-red muscle fibers (HP:0003200)1.97954271
148Hyperglycinemia (HP:0002154)1.97591919
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96324181
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96324181
151Abnormality of polysaccharide metabolism (HP:0011012)1.96324181
152Polygenic inheritance (HP:0010982)1.94197391
153Hyperglycemia (HP:0003074)1.93152181
154IgG deficiency (HP:0004315)1.92309491
155Erythema (HP:0010783)1.91252779
156Severe combined immunodeficiency (HP:0004430)1.91233294
157Thrombocytosis (HP:0001894)1.89936203
158Pulmonary infiltrates (HP:0002113)1.87976886
159Chest pain (HP:0100749)1.87368412
160Dehydration (HP:0001944)1.87257382
161Abnormality of the peritoneum (HP:0002585)1.87124147
162Congenital glaucoma (HP:0001087)1.87120429
163Progressive neurologic deterioration (HP:0002344)1.86720524
164Combined immunodeficiency (HP:0005387)1.86663167
165Chronic sinusitis (HP:0011109)1.84841801
166Blepharitis (HP:0000498)1.84201612
167IgA deficiency (HP:0002720)1.83274141
168Neutropenia (HP:0001875)1.82048677
169Skin rash (HP:0000988)1.81155034
170Hypohidrosis (HP:0000966)1.79617110
171Thoracic kyphosis (HP:0002942)1.79154870
172Hypoplasia of the uterus (HP:0000013)1.77841017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN19.17457542
2BCKDK7.65050153
3TAOK33.70078460
4NME23.50753969
5EIF2AK33.09827071
6RIPK42.95537316
7PRPF4B2.92231140
8SMG12.55466284
9IRAK32.46842986
10INSRR2.34467777
11BLK2.25874209
12MAPKAPK32.00091076
13FRK1.96771301
14KIT1.92105469
15VRK21.88746819
16AKT31.81094899
17TNK21.79453094
18EEF2K1.78313328
19MAP2K21.63879533
20MAP3K111.55788331
21MAP3K131.50832719
22SCYL21.49740606
23PASK1.40207222
24MAPK151.39531293
25TBK11.38415117
26FLT31.37243121
27MAP4K11.33422701
28ARAF1.33387921
29TYK21.33086897
30BRAF1.29496824
31KDR1.23401668
32PIK3CG1.19780248
33CDC71.19006622
34CDK41.18127293
35FGFR41.17708087
36MST1R1.16672146
37KSR21.16613880
38SIK11.14974217
39MAP3K91.14353835
40FES1.14105995
41CSK1.09940754
42RPS6KB21.07400056
43IRAK41.04390809
44MAP3K141.02905535
45MAP3K21.02257593
46TRIB30.99652719
47IKBKE0.99492650
48HCK0.97904677
49LATS10.97806262
50TXK0.93028690
51IRAK20.90781843
52HIPK20.90093851
53PRKD30.87262290
54TESK20.86248326
55CDK190.86199178
56CSF1R0.83807198
57MATK0.83667084
58STK240.80278579
59ITK0.79392598
60ZAP700.79389222
61EIF2AK10.77570272
62PRKCI0.71242865
63LCK0.69018693
64JAK30.67926082
65TLK10.67742902
66TESK10.67270083
67PIM10.66975151
68PKN20.65902882
69MAP2K60.64126413
70TAOK10.64070735
71MST40.62500221
72IRAK10.62081043
73RAF10.61710354
74ACVR1B0.60210623
75PIM20.59297364
76TAOK20.57123893
77CDK120.56971101
78SYK0.54935918
79CDK70.53818620
80RIPK10.53504019
81BMX0.53123558
82WNK40.52779741
83MAP3K80.51484642
84PAK20.50059957
85CDK90.49668269
86NME10.49536902
87PDK10.47601717
88MAPKAPK20.46790152
89PRKG20.45515345
90ATR0.44578322
91NTRK10.44360948
92MAPK120.43262217
93MAP2K10.43163787
94NEK20.42459942
95MOS0.42093231
96RPS6KL10.40233275
97RPS6KC10.40233275
98FGFR30.39547784
99PDK20.37761984
100MAPK40.36306962
101GRK60.35397098
102CHUK0.35332745
103MTOR0.34784207
104MAP2K30.33860953
105NLK0.33609645
106MAP3K10.33082794
107MAPK110.32423452
108MAPK70.31604159
109RPS6KA60.31454592
110CHEK20.30895988
111EPHB10.30205083
112PTK60.30103221
113SIK20.30057787
114RPS6KB10.29780376
115PRKCD0.29411939
116LYN0.27244554
117BTK0.24943525
118PDPK10.24909425
119IKBKB0.24124513
120PRKCH0.22051539
121RET0.21012664
122JAK20.20173437
123PRKD20.19252288
124MAPK30.18180287
125CDC42BPA0.16715199
126PRKAA10.16212757
127MAP3K30.14399268
128CSNK1A10.14101565
129GRK10.13574621
130DYRK1A0.13415772
131BRSK20.13361717
132MET0.12747462
133MAP3K60.12490184
134JAK10.12238613
135PDGFRA0.11301775
136RPS6KA10.10290047
137PRKCQ0.08978267
138MUSK0.08418164
139MAP3K100.07114639
140STK100.07110322
141PDGFRB0.06710360
142TEC0.06511818
143ABL10.06177802
144LRRK20.04413892
145MELK0.04107379
146PDK30.03408318

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030608.50707832
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041415.32907174
3Pancreatic secretion_Homo sapiens_hsa049724.57459929
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.19173972
5Asthma_Homo sapiens_hsa053104.13845746
6Allograft rejection_Homo sapiens_hsa053303.74885791
7Autoimmune thyroid disease_Homo sapiens_hsa053203.55408629
8Graft-versus-host disease_Homo sapiens_hsa053323.39747695
9N-Glycan biosynthesis_Homo sapiens_hsa005103.27469939
10Fat digestion and absorption_Homo sapiens_hsa049753.14574531
11Folate biosynthesis_Homo sapiens_hsa007903.11796050
12Staphylococcus aureus infection_Homo sapiens_hsa051503.11312297
13Protein digestion and absorption_Homo sapiens_hsa049743.08765672
14DNA replication_Homo sapiens_hsa030302.56079700
15Leishmaniasis_Homo sapiens_hsa051402.40216881
16Other glycan degradation_Homo sapiens_hsa005112.11971288
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11085199
18Viral myocarditis_Homo sapiens_hsa054161.96200846
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95846180
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72491006
21Vibrio cholerae infection_Homo sapiens_hsa051101.72243424
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66844023
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.63934904
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63730464
25Sulfur metabolism_Homo sapiens_hsa009201.59472495
26Glycerolipid metabolism_Homo sapiens_hsa005611.59171512
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57976834
28Herpes simplex infection_Homo sapiens_hsa051681.57306166
29Selenocompound metabolism_Homo sapiens_hsa004501.50415936
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.49441529
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41873954
32Hematopoietic cell lineage_Homo sapiens_hsa046401.36380659
33Osteoclast differentiation_Homo sapiens_hsa043801.25233245
34Tuberculosis_Homo sapiens_hsa051521.24513303
35Mismatch repair_Homo sapiens_hsa034301.13388630
36Pertussis_Homo sapiens_hsa051331.13109068
37Systemic lupus erythematosus_Homo sapiens_hsa053221.12845798
38Propanoate metabolism_Homo sapiens_hsa006401.07864834
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04446976
40Acute myeloid leukemia_Homo sapiens_hsa052211.04200123
41Rheumatoid arthritis_Homo sapiens_hsa053231.02793940
42Homologous recombination_Homo sapiens_hsa034400.99546103
43Arginine and proline metabolism_Homo sapiens_hsa003300.96949040
44Antigen processing and presentation_Homo sapiens_hsa046120.96227821
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95591128
46Renin-angiotensin system_Homo sapiens_hsa046140.94619148
47Fructose and mannose metabolism_Homo sapiens_hsa000510.93832097
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93270799
49Thyroid hormone synthesis_Homo sapiens_hsa049180.88696074
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87769181
51Biosynthesis of amino acids_Homo sapiens_hsa012300.83082733
52Sulfur relay system_Homo sapiens_hsa041220.82144270
53Linoleic acid metabolism_Homo sapiens_hsa005910.81613660
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.81286385
55Measles_Homo sapiens_hsa051620.79433638
56Vitamin digestion and absorption_Homo sapiens_hsa049770.77956268
57HTLV-I infection_Homo sapiens_hsa051660.77925541
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77301713
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75788587
60Regulation of autophagy_Homo sapiens_hsa041400.74584011
61Chemokine signaling pathway_Homo sapiens_hsa040620.74558293
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73903089
63Insulin secretion_Homo sapiens_hsa049110.69528764
64One carbon pool by folate_Homo sapiens_hsa006700.69060583
65Lysosome_Homo sapiens_hsa041420.67505981
66Arachidonic acid metabolism_Homo sapiens_hsa005900.66652849
67Legionellosis_Homo sapiens_hsa051340.66077201
68Primary immunodeficiency_Homo sapiens_hsa053400.63700290
69B cell receptor signaling pathway_Homo sapiens_hsa046620.62852066
70Influenza A_Homo sapiens_hsa051640.60873179
71Glutathione metabolism_Homo sapiens_hsa004800.58692375
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58506582
73Phagosome_Homo sapiens_hsa041450.58444226
74TNF signaling pathway_Homo sapiens_hsa046680.57169690
75Tryptophan metabolism_Homo sapiens_hsa003800.56690648
76Fatty acid degradation_Homo sapiens_hsa000710.53409372
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53280666
78Apoptosis_Homo sapiens_hsa042100.52468446
79Pyruvate metabolism_Homo sapiens_hsa006200.52139427
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.49416299
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48670095
82Starch and sucrose metabolism_Homo sapiens_hsa005000.48330233
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46455337
84T cell receptor signaling pathway_Homo sapiens_hsa046600.46172167
85Prostate cancer_Homo sapiens_hsa052150.45852317
86Viral carcinogenesis_Homo sapiens_hsa052030.45732035
87Galactose metabolism_Homo sapiens_hsa000520.44699655
88Malaria_Homo sapiens_hsa051440.44581538
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44513801
90Steroid biosynthesis_Homo sapiens_hsa001000.44027043
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43600241
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42937493
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42595959
94beta-Alanine metabolism_Homo sapiens_hsa004100.41884545
95African trypanosomiasis_Homo sapiens_hsa051430.41397208
96Metabolic pathways_Homo sapiens_hsa011000.40505071
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40255970
98Histidine metabolism_Homo sapiens_hsa003400.40177448
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38383930
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37991373
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37165677
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.35967324
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.34399269
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.33049935
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32572184
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32459812
107Pancreatic cancer_Homo sapiens_hsa052120.31934970
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31802059
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30484444
110Non-homologous end-joining_Homo sapiens_hsa034500.30460446
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30141806
112Non-small cell lung cancer_Homo sapiens_hsa052230.27203589
113Nucleotide excision repair_Homo sapiens_hsa034200.26891333
114Caffeine metabolism_Homo sapiens_hsa002320.25100662
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22142423
116Chronic myeloid leukemia_Homo sapiens_hsa052200.21210142
117Cell cycle_Homo sapiens_hsa041100.20824183
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19832893
119Fanconi anemia pathway_Homo sapiens_hsa034600.19561303
120Spliceosome_Homo sapiens_hsa030400.18521966
121Fatty acid metabolism_Homo sapiens_hsa012120.18322472
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16992017
123Arginine biosynthesis_Homo sapiens_hsa002200.16867827
124Prion diseases_Homo sapiens_hsa050200.16532875
125Phenylalanine metabolism_Homo sapiens_hsa003600.15858041
126Pyrimidine metabolism_Homo sapiens_hsa002400.15261177
127Insulin resistance_Homo sapiens_hsa049310.14129219
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13475527
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12870255
130Cocaine addiction_Homo sapiens_hsa050300.12268344
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12244230
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11524877
133Peroxisome_Homo sapiens_hsa041460.10739283
134Base excision repair_Homo sapiens_hsa034100.09882326
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.08531634
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.08154973
137Carbon metabolism_Homo sapiens_hsa012000.07679562
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07612522
139p53 signaling pathway_Homo sapiens_hsa041150.06079965
140Bladder cancer_Homo sapiens_hsa052190.05943416
141Inositol phosphate metabolism_Homo sapiens_hsa005620.05545768
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05354315
143Hepatitis C_Homo sapiens_hsa051600.05311427
144Epstein-Barr virus infection_Homo sapiens_hsa051690.04253612
145Ribosome_Homo sapiens_hsa030100.03432880
146Prolactin signaling pathway_Homo sapiens_hsa049170.03257973
147mTOR signaling pathway_Homo sapiens_hsa041500.01950067
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.01764045
149Type I diabetes mellitus_Homo sapiens_hsa049400.00963189
150Toxoplasmosis_Homo sapiens_hsa051450.00109157
151Ether lipid metabolism_Homo sapiens_hsa005650.00010339
152Pentose phosphate pathway_Homo sapiens_hsa00030-0.0096366
153Hepatitis B_Homo sapiens_hsa05161-0.0034765

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