DESI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.08345817
2ensheathment of neurons (GO:0007272)6.67771620
3axon ensheathment (GO:0008366)6.67771620
4myelination (GO:0042552)6.62527326
5myelin maintenance (GO:0043217)5.68137725
6long-chain fatty acid biosynthetic process (GO:0042759)5.44107064
7oligodendrocyte differentiation (GO:0048709)4.72149835
8negative regulation of neurotransmitter secretion (GO:0046929)4.63212268
9apical protein localization (GO:0045176)4.60215889
10establishment of mitochondrion localization (GO:0051654)4.59736601
11asymmetric protein localization (GO:0008105)4.41522566
12negative regulation of neurotransmitter transport (GO:0051589)4.35715543
13creatine metabolic process (GO:0006600)4.32734763
14response to methylmercury (GO:0051597)4.16475456
15positive regulation of oligodendrocyte differentiation (GO:0048714)4.03382248
16regulation of early endosome to late endosome transport (GO:2000641)4.03263067
17glycerophospholipid catabolic process (GO:0046475)4.02542225
18cholesterol biosynthetic process (GO:0006695)4.02199251
19L-amino acid import (GO:0043092)3.89548341
20long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.86366661
21regulation of collateral sprouting (GO:0048670)3.83897118
22regulation of vitamin D biosynthetic process (GO:0060556)3.83681133
23presynaptic membrane organization (GO:0097090)3.82646635
24peptidyl-tyrosine autophosphorylation (GO:0038083)3.82623151
25protein palmitoylation (GO:0018345)3.79998256
26eye photoreceptor cell differentiation (GO:0001754)3.75759675
27photoreceptor cell differentiation (GO:0046530)3.75759675
28astrocyte development (GO:0014002)3.72208601
29substantia nigra development (GO:0021762)3.71724888
30response to redox state (GO:0051775)3.56308732
31negative regulation of protein localization to cell surface (GO:2000009)3.54395377
32magnesium ion transport (GO:0015693)3.53405822
33sterol biosynthetic process (GO:0016126)3.50077286
34long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.48884796
35presynaptic membrane assembly (GO:0097105)3.47990461
36low-density lipoprotein particle clearance (GO:0034383)3.46972727
37adult walking behavior (GO:0007628)3.44383438
38fatty-acyl-CoA biosynthetic process (GO:0046949)3.32463536
39import into cell (GO:0098657)3.29378751
40negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26842074
41negative regulation of inclusion body assembly (GO:0090084)3.24631458
42dicarboxylic acid biosynthetic process (GO:0043650)3.22736465
43membrane tubulation (GO:0097320)3.19437525
44neuronal action potential propagation (GO:0019227)3.18823254
45peptidyl-cysteine modification (GO:0018198)3.18546868
46activation of MAPKKK activity (GO:0000185)3.17531018
47NIK/NF-kappaB signaling (GO:0038061)3.16216008
48transmission of nerve impulse (GO:0019226)3.15596366
49GDP-mannose metabolic process (GO:0019673)3.14333711
50cellular response to arsenic-containing substance (GO:0071243)3.13958099
51response to lipoprotein particle (GO:0055094)3.13141575
52glycosylceramide metabolic process (GO:0006677)3.12116142
53amyloid precursor protein metabolic process (GO:0042982)3.11632444
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09785273
55negative regulation of JUN kinase activity (GO:0043508)3.07280133
56neuron cell-cell adhesion (GO:0007158)3.06998339
57negative regulation of axonogenesis (GO:0050771)3.06125673
58mannose metabolic process (GO:0006013)3.04470820
59myeloid dendritic cell differentiation (GO:0043011)3.03761739
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03292599
61L-phenylalanine metabolic process (GO:0006558)3.03292599
62fatty-acyl-CoA metabolic process (GO:0035337)3.02558010
63positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.02263826
64axon development (GO:0061564)3.01773628
65nerve growth factor signaling pathway (GO:0038180)2.99902313
66amino acid import (GO:0043090)2.94523106
67adhesion of symbiont to host cell (GO:0044650)2.92605924
68virion attachment to host cell (GO:0019062)2.92605924
69urea metabolic process (GO:0019627)2.92252420
70synaptic vesicle maturation (GO:0016188)2.92247774
71regulation of vitamin metabolic process (GO:0030656)2.91444895
72proline biosynthetic process (GO:0006561)2.90520467
73peripheral nervous system axon ensheathment (GO:0032292)2.89452220
74myelination in peripheral nervous system (GO:0022011)2.89452220
75isoprenoid biosynthetic process (GO:0008299)2.87846122
76urea cycle (GO:0000050)2.86747006
77neuronal ion channel clustering (GO:0045161)2.86382756
78GPI anchor biosynthetic process (GO:0006506)2.86316564
79GPI anchor metabolic process (GO:0006505)2.86106722
80positive regulation of chemokine biosynthetic process (GO:0045080)2.85722436
81stress fiber assembly (GO:0043149)2.81325834
82negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81057767
83regulation of autophagic vacuole assembly (GO:2000785)2.79571204
84regulation of lipoprotein metabolic process (GO:0050746)2.79131332
85positive regulation of glial cell differentiation (GO:0045687)2.78689537
86modulation by symbiont of host cellular process (GO:0044068)2.77380785
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.77291090
88apoptotic process involved in morphogenesis (GO:0060561)2.75629563
89negative regulation of fibrinolysis (GO:0051918)2.75200825
90regulation of mammary gland epithelial cell proliferation (GO:0033599)2.73176007
91regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72336861
92positive regulation of protein dephosphorylation (GO:0035307)2.72007844
93regulation of catecholamine metabolic process (GO:0042069)2.71290193
94regulation of dopamine metabolic process (GO:0042053)2.71290193
95adhesion of symbiont to host (GO:0044406)2.70974517
96L-phenylalanine catabolic process (GO:0006559)2.70359899
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70359899
98very long-chain fatty acid metabolic process (GO:0000038)2.69378947
99COPI coating of Golgi vesicle (GO:0048205)2.69084282
100Golgi transport vesicle coating (GO:0048200)2.69084282
101positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68546589
102regulation of NFAT protein import into nucleus (GO:0051532)2.66852008
103iron coordination entity transport (GO:1901678)2.66817779
104regulation of translational termination (GO:0006449)2.65483353
105oxaloacetate metabolic process (GO:0006107)2.65251191
106response to lead ion (GO:0010288)2.65139711
107response to dietary excess (GO:0002021)2.64588817
108sodium ion export (GO:0071436)2.63641722
109Golgi to endosome transport (GO:0006895)2.62342517
110neurotransmitter uptake (GO:0001504)2.62139788
111peptidyl-arginine omega-N-methylation (GO:0035247)2.62134954
112nitrogen cycle metabolic process (GO:0071941)2.61651368
113positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.61341228
114activation of Rac GTPase activity (GO:0032863)2.60095284
115protein localization to endosome (GO:0036010)2.59489237
116preassembly of GPI anchor in ER membrane (GO:0016254)2.59217348
117thioester biosynthetic process (GO:0035384)2.58820086
118acyl-CoA biosynthetic process (GO:0071616)2.58820086
119cell-substrate adherens junction assembly (GO:0007045)2.58661393
120focal adhesion assembly (GO:0048041)2.58661393
121positive regulation of action potential (GO:0045760)2.58261530
122negative regulation of execution phase of apoptosis (GO:1900118)2.58021872
123folic acid metabolic process (GO:0046655)2.57135139
124cerebral cortex radially oriented cell migration (GO:0021799)2.57130267
125glycine transport (GO:0015816)2.57000098
126cell-substrate junction assembly (GO:0007044)2.55450759
127mitochondrion transport along microtubule (GO:0047497)2.54326384
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.54326384
129glycosphingolipid catabolic process (GO:0046479)2.54161175
130serine transport (GO:0032329)2.53411423
131protein carboxylation (GO:0018214)2.52842090
132peptidyl-glutamic acid carboxylation (GO:0017187)2.52842090
133glial cell development (GO:0021782)2.52471419
134glial cell differentiation (GO:0010001)2.52226339
135neurotransmitter catabolic process (GO:0042135)2.51830278
136positive regulation of gliogenesis (GO:0014015)2.51522205
137negative regulation of fatty acid transport (GO:2000192)2.50995971
138positive regulation of cellular amine metabolic process (GO:0033240)2.50926771
139negative regulation of fatty acid biosynthetic process (GO:0045717)2.50678037
140regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49299522
141germinal center formation (GO:0002467)2.49287408
142detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.48139943
143detection of temperature stimulus involved in sensory perception (GO:0050961)2.48139943
144cellular response to epinephrine stimulus (GO:0071872)2.47943839
145cerebellar granule cell differentiation (GO:0021707)2.47907021
146retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47811914
147regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.47758260
148regulation of translational fidelity (GO:0006450)2.47624862
149cyclic nucleotide catabolic process (GO:0009214)2.47478883
150regulation of cholesterol biosynthetic process (GO:0045540)2.46698960
151dendritic spine morphogenesis (GO:0060997)2.46100064
152positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.45380300
153regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45280965
154leukocyte migration involved in inflammatory response (GO:0002523)2.44977812
155positive regulation of immune response to tumor cell (GO:0002839)2.44837703
156regulation of immune response to tumor cell (GO:0002837)2.44837703
157regulation of response to tumor cell (GO:0002834)2.44837703
158positive regulation of response to tumor cell (GO:0002836)2.44837703
159neural nucleus development (GO:0048857)2.44513996
160cellular protein complex localization (GO:0034629)2.43667634
161negative regulation of lipid transport (GO:0032369)2.43441427
162negative regulation of cholesterol transport (GO:0032375)2.41829258
163negative regulation of sterol transport (GO:0032372)2.41829258
164adherens junction assembly (GO:0034333)2.41717350
165negative regulation of macroautophagy (GO:0016242)2.40904530
166regulation of chemokine biosynthetic process (GO:0045073)2.40646293
167proline metabolic process (GO:0006560)2.40150077
168regulation of fibrinolysis (GO:0051917)2.39930079
169hemidesmosome assembly (GO:0031581)2.38995745
170diaphragm development (GO:0060539)2.37210418
171adenosine receptor signaling pathway (GO:0001973)2.35571803
172protein retention in ER lumen (GO:0006621)2.34558276
173spliceosomal tri-snRNP complex assembly (GO:0000244)2.33965465
174negative regulation of interleukin-12 production (GO:0032695)2.33635709
175regulation of podosome assembly (GO:0071801)2.33562382
176positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.32728955
177regulation of cholesterol homeostasis (GO:2000188)2.32454518
178regulation of oxidative phosphorylation (GO:0002082)2.28853717
179cortical actin cytoskeleton organization (GO:0030866)2.27418109
180activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23528071
181glycolipid catabolic process (GO:0019377)2.23446366
182maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.23147828
183regulation of necrotic cell death (GO:0010939)2.23018157
184CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.22830860
185regulation of cholesterol storage (GO:0010885)2.21729321
186leukocyte apoptotic process (GO:0071887)2.21423583
187regulation of chronic inflammatory response (GO:0002676)2.21250156
188antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.19898434
189plasma lipoprotein particle clearance (GO:0034381)2.19429074
190fibrinolysis (GO:0042730)2.18206106
191negative regulation of viral release from host cell (GO:1902187)2.16365024
192protein complex localization (GO:0031503)2.15828383
193axon ensheathment in central nervous system (GO:0032291)11.2800010
194central nervous system myelination (GO:0022010)11.2800010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.00746443
2EZH2_22144423_ChIP-Seq_EOC_Human2.96730120
3GBX2_23144817_ChIP-Seq_PC3_Human2.81470041
4MYC_22102868_ChIP-Seq_BL_Human2.74000984
5LXR_22292898_ChIP-Seq_THP-1_Human2.67475204
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61742518
7VDR_21846776_ChIP-Seq_THP-1_Human2.57141993
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.44896434
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42608294
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38468495
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35857901
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35149689
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34442579
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33799988
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27326409
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26875407
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24841714
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24688591
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.21831223
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14254774
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12246192
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.09385750
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.07336503
24DROSHA_22980978_ChIP-Seq_HELA_Human2.04970023
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.03562812
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00990726
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00990726
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00419289
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97564535
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97306205
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95415874
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95230445
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90788547
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90116279
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85525653
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83191731
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82070401
38TAF15_26573619_Chip-Seq_HEK293_Human1.81790602
39RACK7_27058665_Chip-Seq_MCF-7_Human1.79003104
40REST_21632747_ChIP-Seq_MESCs_Mouse1.77730386
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.76720821
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74796000
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.74340209
44AR_21572438_ChIP-Seq_LNCaP_Human1.73048662
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71445194
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70973599
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70769739
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69435810
49KDM2B_26808549_Chip-Seq_DND41_Human1.68582774
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61101761
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61078626
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.60427954
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.60215441
54P68_20966046_ChIP-Seq_HELA_Human1.59133386
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59001903
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.58618656
57VDR_22108803_ChIP-Seq_LS180_Human1.55450363
58KDM2B_26808549_Chip-Seq_K562_Human1.54621475
59SMC4_20622854_ChIP-Seq_HELA_Human1.54240673
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.48681708
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.48025864
62ZNF263_19887448_ChIP-Seq_K562_Human1.46774340
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46693228
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.45312981
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42661174
66TCF7_22412390_ChIP-Seq_EML_Mouse1.42473942
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42061564
68ER_23166858_ChIP-Seq_MCF-7_Human1.41237854
69MAF_26560356_Chip-Seq_TH1_Human1.41113781
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.40795049
71MAF_26560356_Chip-Seq_TH2_Human1.39059643
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38790527
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38682605
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38323291
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37193052
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37043085
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36827650
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36382125
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36174651
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35410027
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34511550
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34029095
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33674220
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33573375
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33309455
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31019376
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.30496381
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29160964
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28439436
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27907824
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27177775
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25689673
93BCOR_27268052_Chip-Seq_Bcells_Human1.25302568
94VDR_24763502_ChIP-Seq_THP-1_Human1.25118630
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21482290
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21137131
97ATF3_27146783_Chip-Seq_COLON_Human1.20426003
98TP53_22127205_ChIP-Seq_IMR90_Human1.19976181
99XRN2_22483619_ChIP-Seq_HELA_Human1.19904996
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19871366
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18216630
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18192033
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18175702
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17630762
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.17564312
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15839804
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15810550
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.15447677
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15152199
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14515959
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13708707
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12962275
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12781651
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12632683
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12628868
116MYC_18555785_ChIP-Seq_MESCs_Mouse1.12536965
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12224047
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11324323
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10898709
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10752235
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10626266
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.09997337
123BCL6_27268052_Chip-Seq_Bcells_Human1.09560155
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.09153815
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09004955
126GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08685936
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08331039
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08141171
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07646043
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07511687
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07428697
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07174030
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07064599
134STAT3_23295773_ChIP-Seq_U87_Human1.06980231
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06838814
136EOMES_21245162_ChIP-Seq_HESCs_Human1.06189361
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05725982
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05704112
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05540851
140UTX_26944678_Chip-Seq_JUKART_Human1.05419815
141UBF1/2_26484160_Chip-Seq_HMECs_Human1.05323223
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05046093
143ESR2_21235772_ChIP-Seq_MCF-7_Human1.04636244
144SA1_27219007_Chip-Seq_Bcells_Human1.03735276
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03460383
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02599204
147RUNX1_22412390_ChIP-Seq_EML_Mouse1.02513852
148NCOR1_26117541_ChIP-Seq_K562_Human1.01939304
149ETS1_21867929_ChIP-Seq_TH2_Mouse1.01857053
150CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01816915
151STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01444708
152CREB1_26743006_Chip-Seq_LNCaP_Human1.01180895
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00721896
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.99983356
155E2F7_22180533_ChIP-Seq_HELA_Human0.99942565
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.99804851
157POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99791421
158CLOCK_20551151_ChIP-Seq_293T_Human0.99329762
159CTCF_27219007_Chip-Seq_Bcells_Human0.98787613
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98775440
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.98603482
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98353279
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97188551
164CTCF_20526341_ChIP-Seq_ESCs_Human0.97083822
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96962464
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.96457796
167TCF4_23295773_ChIP-Seq_U87_Human0.96046936
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95966137
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95621747
170TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94636735
171HTT_18923047_ChIP-ChIP_STHdh_Human0.93844660
172NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91475686
173BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91195620
174TAL1_26923725_Chip-Seq_HPCs_Mouse0.90899907
175NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90653525
176RING1B_27294783_Chip-Seq_NPCs_Mouse0.90530590
177LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90196318
178TBL1_22424771_ChIP-Seq_293T_Human0.90091796
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.89017651
180WT1_19549856_ChIP-ChIP_CCG9911_Human0.88745515
181P300_19829295_ChIP-Seq_ESCs_Human0.88311766
182RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87037360
183NCOR_22424771_ChIP-Seq_293T_Human0.86706870
184MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85254883
185TET1_21490601_ChIP-Seq_MESCs_Mouse0.85171938
186NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84936953
187NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84936953
188PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84253190
189MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84247338
190AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83910394
191CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83820313
192RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82645778
193EP300_21415370_ChIP-Seq_HL-1_Mouse0.82296773
194SMAD4_21741376_ChIP-Seq_EPCs_Human0.81463938
195SMAD4_21799915_ChIP-Seq_A2780_Human0.81088414
196RNF2_27304074_Chip-Seq_NSC_Mouse0.80857946
197SOX2_21211035_ChIP-Seq_LN229_Gbm0.80826848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.28578495
2MP0003880_abnormal_central_pattern3.99364990
3MP0004270_analgesia3.79179036
4MP0003950_abnormal_plasma_membrane3.36128470
5MP0003705_abnormal_hypodermis_morpholog3.27523214
6MP0002139_abnormal_hepatobiliary_system3.16738007
7MP0003303_peritoneal_inflammation3.13093475
8MP0004859_abnormal_synaptic_plasticity3.08402503
9MP0003329_amyloid_beta_deposits3.05252628
10MP0005410_abnormal_fertilization2.84792734
11MP0004885_abnormal_endolymph2.83487421
12MP0003690_abnormal_glial_cell2.77144539
13MP0002877_abnormal_melanocyte_morpholog2.76324887
14MP0002272_abnormal_nervous_system2.64860777
15MP0001529_abnormal_vocalization2.64185354
16MP0004233_abnormal_muscle_weight2.47955708
17MP0004510_myositis2.47443407
18MP0002064_seizures2.45346734
19MP0001486_abnormal_startle_reflex2.43157737
20MP0003436_decreased_susceptibility_to2.43022854
21MP0003634_abnormal_glial_cell2.37253092
22MP0003635_abnormal_synaptic_transmissio2.30199894
23MP0004742_abnormal_vestibular_system2.25613260
24MP0001905_abnormal_dopamine_level2.25460870
25MP0004142_abnormal_muscle_tone2.25352708
26MP0004043_abnormal_pH_regulation2.23915752
27MP0000685_abnormal_immune_system2.23215997
28MP0005423_abnormal_somatic_nervous2.02822683
29MP0002229_neurodegeneration2.01179107
30MP0009745_abnormal_behavioral_response1.97446649
31MP0009046_muscle_twitch1.94789282
32MP0005409_darkened_coat_color1.94153990
33MP0000778_abnormal_nervous_system1.94043110
34MP0001485_abnormal_pinna_reflex1.92495738
35MP0002734_abnormal_mechanical_nocicepti1.91593947
36MP0004858_abnormal_nervous_system1.88288623
37MP0003453_abnormal_keratinocyte_physiol1.85248050
38MP0002148_abnormal_hypersensitivity_rea1.84829051
39MP0001790_abnormal_immune_system1.82601215
40MP0005387_immune_system_phenotype1.82601215
41MP0003075_altered_response_to1.81467810
42MP0004947_skin_inflammation1.81395977
43MP0003632_abnormal_nervous_system1.80202812
44MP0003566_abnormal_cell_adhesion1.78382854
45MP0005551_abnormal_eye_electrophysiolog1.76519179
46MP0003300_gastrointestinal_ulcer1.72394711
47MP0000462_abnormal_digestive_system1.70425976
48MP0000955_abnormal_spinal_cord1.69621287
49MP0009333_abnormal_splenocyte_physiolog1.69408134
50MP0009785_altered_susceptibility_to1.68398618
51MP0008569_lethality_at_weaning1.68327027
52MP0002063_abnormal_learning/memory/cond1.64371660
53MP0003136_yellow_coat_color1.60089692
54MP0002572_abnormal_emotion/affect_behav1.58322406
55MP0005000_abnormal_immune_tolerance1.56501261
56MP0001835_abnormal_antigen_presentation1.56101301
57MP0001849_ear_inflammation1.50416341
58MP0003172_abnormal_lysosome_physiology1.49787310
59MP0005171_absent_coat_pigmentation1.49379886
60MP0002882_abnormal_neuron_morphology1.48819347
61MP0005451_abnormal_body_composition1.48305112
62MP0003631_nervous_system_phenotype1.47581976
63MP0000604_amyloidosis1.42572143
64MP0002138_abnormal_hepatobiliary_system1.41959266
65MP0000343_altered_response_to1.41020818
66MP0005167_abnormal_blood-brain_barrier1.38653585
67MP0010678_abnormal_skin_adnexa1.38077182
68MP0003191_abnormal_cellular_cholesterol1.37225735
69MP0008874_decreased_physiological_sensi1.37202579
70MP0002066_abnormal_motor_capabilities/c1.36639787
71MP0003633_abnormal_nervous_system1.36229155
72MP0003091_abnormal_cell_migration1.35293744
73MP0001970_abnormal_pain_threshold1.35259235
74MP0005076_abnormal_cell_differentiation1.34713697
75MP0004381_abnormal_hair_follicle1.33715687
76MP0002067_abnormal_sensory_capabilities1.29080061
77MP0000858_altered_metastatic_potential1.27762067
78MP0006072_abnormal_retinal_apoptosis1.26576687
79MP0001440_abnormal_grooming_behavior1.26523860
80MP0001299_abnormal_eye_distance/1.25502386
81MP0000747_muscle_weakness1.25233805
82MP0000678_abnormal_parathyroid_gland1.24754193
83MP0005025_abnormal_response_to1.24596978
84MP0004924_abnormal_behavior1.22749286
85MP0005386_behavior/neurological_phenoty1.22749286
86MP0002733_abnormal_thermal_nociception1.21689972
87MP0003045_fibrosis1.19128282
88MP0008438_abnormal_cutaneous_collagen1.19065225
89MP0001800_abnormal_humoral_immune1.17730747
90MP0005166_decreased_susceptibility_to1.17510547
91MP0003195_calcinosis1.17030772
92MP0002419_abnormal_innate_immunity1.15703641
93MP0002752_abnormal_somatic_nervous1.13452991
94MP0005671_abnormal_response_to1.13028407
95MP0002723_abnormal_immune_serum1.10800187
96MP0005165_increased_susceptibility_to1.10047320
97MP0004145_abnormal_muscle_electrophysio1.09003501
98MP0003763_abnormal_thymus_physiology1.07942968
99MP0000609_abnormal_liver_physiology1.07791904
100MP0005670_abnormal_white_adipose1.05176649
101MP0001502_abnormal_circadian_rhythm1.04020573
102MP0001963_abnormal_hearing_physiology1.03925480
103MP0003806_abnormal_nucleotide_metabolis1.03820550
104MP0000383_abnormal_hair_follicle1.03777577
105MP0000013_abnormal_adipose_tissue1.03744505
106MP0002452_abnormal_antigen_presenting1.03491778
107MP0002332_abnormal_exercise_endurance1.03382524
108MP0009780_abnormal_chondrocyte_physiolo1.03288291
109MP0005375_adipose_tissue_phenotype1.02222157
110MP0009764_decreased_sensitivity_to1.02215189
111MP0004147_increased_porphyrin_level1.01232944
112MP0008260_abnormal_autophagy1.00660230
113MP0008469_abnormal_protein_level1.00318119
114MP0005195_abnormal_posterior_eye1.00213666
115MP0001661_extended_life_span0.99866786
116MP0002090_abnormal_vision0.98895059
117MP0004130_abnormal_muscle_cell0.98424171
118MP0001533_abnormal_skeleton_physiology0.98334263
119MP0005360_urolithiasis0.98027376
120MP0005253_abnormal_eye_physiology0.97753501
121MP0003448_altered_tumor_morphology0.96990311
122MP0002152_abnormal_brain_morphology0.96829882
123MP0004134_abnormal_chest_morphology0.96767453
124MP0002822_catalepsy0.96714880
125MP0003879_abnormal_hair_cell0.95211765
126MP0004811_abnormal_neuron_physiology0.94220234
127MP0005365_abnormal_bile_salt0.93755517
128MP0000003_abnormal_adipose_tissue0.93727151
129MP0005023_abnormal_wound_healing0.93645810
130MP0005666_abnormal_adipose_tissue0.93070206
131MP0001845_abnormal_inflammatory_respons0.92514997
132MP0005058_abnormal_lysosome_morphology0.90895139
133MP0005623_abnormal_meninges_morphology0.90786232
134MP0005621_abnormal_cell_physiology0.88588371
135MP0002420_abnormal_adaptive_immunity0.87390270
136MP0006082_CNS_inflammation0.87060019
137MP0001819_abnormal_immune_cell0.87014687
138MP0001346_abnormal_lacrimal_gland0.86895195
139MP0003279_aneurysm0.86665316
140MP0001968_abnormal_touch/_nociception0.85186713
141MP0003698_abnormal_male_reproductive0.84881938
142MP0002089_abnormal_postnatal_growth/wei0.84670336
143MP0002184_abnormal_innervation0.84571848
144MP0010352_gastrointestinal_tract_polyps0.83908938
145MP0001348_abnormal_lacrimal_gland0.83200563
146MP0004185_abnormal_adipocyte_glucose0.82397898
147MP0008007_abnormal_cellular_replicative0.82027956
148MP0000733_abnormal_muscle_development0.81337439
149MP0001851_eye_inflammation0.81123498
150MP0001873_stomach_inflammation0.80998542
151MP0002557_abnormal_social/conspecific_i0.80931255
152MP0002796_impaired_skin_barrier0.80850853
153MP0000647_abnormal_sebaceous_gland0.79486265
154MP0005584_abnormal_enzyme/coenzyme_acti0.78721092
155MP0009840_abnormal_foam_cell0.77712499
156MP0005310_abnormal_salivary_gland0.76421098
157MP0000750_abnormal_muscle_regeneration0.76418356
158MP0001853_heart_inflammation0.75821561
159MP0010307_abnormal_tumor_latency0.74714819
160MP0001730_embryonic_growth_arrest0.74709706
161MP0001501_abnormal_sleep_pattern0.73865156
162MP0005332_abnormal_amino_acid0.73577467
163MP0002998_abnormal_bone_remodeling0.73532351
164MP0005464_abnormal_platelet_physiology0.72751570
165MP0001216_abnormal_epidermal_layer0.72421529
166MP0002398_abnormal_bone_marrow0.72331975
167MP0000716_abnormal_immune_system0.71855890
168MP0005319_abnormal_enzyme/_coenzyme0.70671732
169MP0010155_abnormal_intestine_physiology0.70109517
170MP0001177_atelectasis0.69242267
171MP0000631_abnormal_neuroendocrine_gland0.68792347
172MP0003938_abnormal_ear_development0.66625788
173MP0000639_abnormal_adrenal_gland0.65802819
174MP0000566_synostosis0.65690916
175MP0002735_abnormal_chemical_nociception0.65181073
176MP0005646_abnormal_pituitary_gland0.62409046
177MP0005645_abnormal_hypothalamus_physiol0.61362797
178MP0000762_abnormal_tongue_morphology0.61153768
179MP0003656_abnormal_erythrocyte_physiolo0.61065642
180MP0000467_abnormal_esophagus_morphology0.58794466
181MP0000579_abnormal_nail_morphology0.57801871
182MP0002069_abnormal_eating/drinking_beha0.57490633
183MP0000026_abnormal_inner_ear0.56899356

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.56919344
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.12162821
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.12162821
4Sensory axonal neuropathy (HP:0003390)5.14791616
5Cerebral inclusion bodies (HP:0100314)4.91324423
6Peripheral hypomyelination (HP:0007182)4.69700739
7Abnormality of the corticospinal tract (HP:0002492)4.68284054
8Supranuclear gaze palsy (HP:0000605)4.53209285
9Cerebral hypomyelination (HP:0006808)4.13135064
10Parakeratosis (HP:0001036)3.99846788
11Spastic gait (HP:0002064)3.95017367
12Onion bulb formation (HP:0003383)3.67457031
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.61073078
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60386203
15Myokymia (HP:0002411)3.59088905
16Intention tremor (HP:0002080)3.53297624
17Abnormal auditory evoked potentials (HP:0006958)3.51621843
18Dysmetria (HP:0001310)3.51319434
19Ankle clonus (HP:0011448)3.39846885
20Deep venous thrombosis (HP:0002625)3.18374032
21Insidious onset (HP:0003587)3.08622034
22Termporal pattern (HP:0011008)3.08622034
23Alacrima (HP:0000522)3.06498416
24Retinal dysplasia (HP:0007973)3.00958739
25Slow saccadic eye movements (HP:0000514)2.96937681
26Hyperacusis (HP:0010780)2.94391942
27Abnormality of glycolipid metabolism (HP:0010969)2.90486551
28Abnormality of liposaccharide metabolism (HP:0010968)2.90486551
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.90486551
30Scanning speech (HP:0002168)2.86826330
31Anteriorly placed anus (HP:0001545)2.84889459
32Megalencephaly (HP:0001355)2.81443267
33Gastrointestinal stroma tumor (HP:0100723)2.81275029
34Akinesia (HP:0002304)2.81087395
35Progressive muscle weakness (HP:0003323)2.69996962
36Leukodystrophy (HP:0002415)2.67590021
37CNS hypomyelination (HP:0003429)2.67056869
38Achilles tendon contracture (HP:0001771)2.62499680
39Clumsiness (HP:0002312)2.62294761
40Abnormality of the Achilles tendon (HP:0005109)2.57595929
41Spastic paraparesis (HP:0002313)2.57552059
42Pheochromocytoma (HP:0002666)2.55132059
43Increased circulating renin level (HP:0000848)2.53218624
44Congenital ichthyosiform erythroderma (HP:0007431)2.53148230
45Thickened helices (HP:0000391)2.49043084
46Ragged-red muscle fibers (HP:0003200)2.46391950
47Spastic tetraparesis (HP:0001285)2.46190831
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41436641
49Dysostosis multiplex (HP:0000943)2.40395616
50Vertebral compression fractures (HP:0002953)2.39086763
51Hypertensive crisis (HP:0100735)2.37475756
52Clonus (HP:0002169)2.36245134
53Decreased lacrimation (HP:0000633)2.35082284
54Hypoplastic pelvis (HP:0008839)2.34725739
55Segmental peripheral demyelination/remyelination (HP:0003481)2.34472495
56Absent septum pellucidum (HP:0001331)2.30028763
57Emphysema (HP:0002097)2.29822904
58Morphological abnormality of the inner ear (HP:0011390)2.26549758
59Premature skin wrinkling (HP:0100678)2.25703776
60Cerebral hemorrhage (HP:0001342)2.23591961
61Split foot (HP:0001839)2.23254075
62Insomnia (HP:0100785)2.23244891
63Increased cerebral lipofuscin (HP:0011813)2.22601517
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21846577
65Lower limb muscle weakness (HP:0007340)2.21005168
66Neuroendocrine neoplasm (HP:0100634)2.19584462
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.16839346
68Absent/shortened dynein arms (HP:0200106)2.16839346
69Action tremor (HP:0002345)2.16664347
70Upper limb amyotrophy (HP:0009129)2.16655275
71Distal upper limb amyotrophy (HP:0007149)2.16655275
72Truncus arteriosus (HP:0001660)2.16636589
73Autoamputation (HP:0001218)2.15879653
74Focal motor seizures (HP:0011153)2.15378121
75Atrioventricular block (HP:0001678)2.13814431
76Myocardial infarction (HP:0001658)2.13252822
77Generalized myoclonic seizures (HP:0002123)2.10517575
78Systemic lupus erythematosus (HP:0002725)2.10194307
79Atonic seizures (HP:0010819)2.08995903
80Hypokalemic alkalosis (HP:0001949)2.07903441
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.06816090
82Metabolic alkalosis (HP:0200114)2.06779212
83Choreoathetosis (HP:0001266)2.05188071
84Dysmetric saccades (HP:0000641)2.05136915
85Coronal craniosynostosis (HP:0004440)2.03305024
86Thoracic kyphosis (HP:0002942)2.02926508
87Orchitis (HP:0100796)2.02242946
88Urinary urgency (HP:0000012)2.01995286
89Abnormality of the thoracic spine (HP:0100711)2.01734653
90Decreased motor nerve conduction velocity (HP:0003431)2.01191792
91Stridor (HP:0010307)2.00725950
92Type II lissencephaly (HP:0007260)2.00498893
93Hemorrhage of the eye (HP:0011885)1.99894922
94Epileptic encephalopathy (HP:0200134)1.97706829
95Complement deficiency (HP:0004431)1.97622939
96Neuronal loss in central nervous system (HP:0002529)1.97100737
97Abnormality of the intrinsic pathway (HP:0010989)1.97070278
98Morphological abnormality of the pyramidal tract (HP:0002062)1.97065696
99Abnormality of polysaccharide metabolism (HP:0011012)1.95858831
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95858831
101Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95858831
102Xanthomatosis (HP:0000991)1.95853578
103Mucopolysacchariduria (HP:0008155)1.95315495
104Urinary glycosaminoglycan excretion (HP:0003541)1.95315495
105Bowel incontinence (HP:0002607)1.95058859
106Progressive neurologic deterioration (HP:0002344)1.94518654
107Abnormality of complement system (HP:0005339)1.94282651
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92568808
109Erythroderma (HP:0001019)1.92510974
110Abnormality of glycolysis (HP:0004366)1.92389846
111Increased serum pyruvate (HP:0003542)1.92389846
112Foot dorsiflexor weakness (HP:0009027)1.90904117
113Poor speech (HP:0002465)1.90419990
114Abnormality of the septum pellucidum (HP:0007375)1.90225836
115Abnormality of saccadic eye movements (HP:0000570)1.88087911
116Urinary incontinence (HP:0000020)1.87052053
117Cholecystitis (HP:0001082)1.86775297
118Abnormal gallbladder physiology (HP:0012438)1.86775297
119IgA deficiency (HP:0002720)1.86740671
120Dysdiadochokinesis (HP:0002075)1.85586009
121Retrobulbar optic neuritis (HP:0100654)1.84045784
122Optic neuritis (HP:0100653)1.84045784
123Purpura (HP:0000979)1.81892734
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.81813240
125Distal sensory impairment (HP:0002936)1.81003351
126Increased serum ferritin (HP:0003281)1.80945516
127Paraparesis (HP:0002385)1.80665988
128Supernumerary nipples (HP:0002558)1.80634289
129Large for gestational age (HP:0001520)1.80594631
130Squamous cell carcinoma (HP:0002860)1.80136780
131Deep palmar crease (HP:0006191)1.79356046
132Postnatal microcephaly (HP:0005484)1.79279201
133Long palpebral fissure (HP:0000637)1.79081510
134Hyporeflexia of lower limbs (HP:0002600)1.78250783
135Progressive external ophthalmoplegia (HP:0000590)1.77124121
136Polygenic inheritance (HP:0010982)1.76644086
137Humeroradial synostosis (HP:0003041)1.76391197
138Synostosis involving the elbow (HP:0003938)1.76391197
139Abnormal large intestine physiology (HP:0012700)1.75342158
140Athetosis (HP:0002305)1.75313393
141Hammertoe (HP:0001765)1.75154476
142Gowers sign (HP:0003391)1.74629560
143Axonal loss (HP:0003447)1.73734514
144Nonimmune hydrops fetalis (HP:0001790)1.73693766
145Aplasia involving bones of the upper limbs (HP:0009823)1.73676677
146Aplasia of the phalanges of the hand (HP:0009802)1.73676677
147Aplasia involving bones of the extremities (HP:0009825)1.73676677
148Hypokinesia (HP:0002375)1.73656618
149Hand muscle atrophy (HP:0009130)1.72962436
150Asymmetric septal hypertrophy (HP:0001670)1.72657515
151Prolonged partial thromboplastin time (HP:0003645)1.72177524
152Loss of speech (HP:0002371)1.72109187
153Reduced antithrombin III activity (HP:0001976)1.72046808
154Self-mutilation (HP:0000742)1.71664712
155Abnormality of the foot musculature (HP:0001436)1.71481890
156Hyperparathyroidism (HP:0000843)1.70242546
157Upper motor neuron abnormality (HP:0002127)1.69798383
158Premature rupture of membranes (HP:0001788)1.69611884
159Ridged nail (HP:0001807)1.68033382
160Hypomagnesemia (HP:0002917)1.68031270
161Focal seizures (HP:0007359)1.67272077
162Hepatosplenomegaly (HP:0001433)1.67036101
163Abnormal atrioventricular conduction (HP:0005150)1.66979965
164Neoplasm of head and neck (HP:0012288)1.66287651
165Esophageal neoplasm (HP:0100751)1.66287651
166Abnormality of the gallbladder (HP:0005264)1.64584160
167Protrusio acetabuli (HP:0003179)1.63684729
168Hypobetalipoproteinemia (HP:0003563)1.62658136
169Selective tooth agenesis (HP:0001592)1.62155989
170Abnormality of the periventricular white matter (HP:0002518)1.61287080
171Disproportionate tall stature (HP:0001519)1.59897705
172Cholelithiasis (HP:0001081)1.58489731
173Hyperthyroidism (HP:0000836)1.57695809
174Glomerulonephritis (HP:0000099)1.54782190
175Resting tremor (HP:0002322)1.54768391
176Trismus (HP:0000211)1.54576548
177Depression (HP:0000716)1.53607371
178Heart block (HP:0012722)1.52334069
179Dementia (HP:0000726)1.51818839
180Elfin facies (HP:0004428)1.50987000
181Ulnar bowing (HP:0003031)1.50279319
182Tetraparesis (HP:0002273)1.50151841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.04790213
2IRAK34.69803030
3TRIB34.34059957
4OXSR14.22799245
5NME23.04274304
6EPHB12.99132782
7WNK42.89449573
8CDK192.84369726
9EEF2K2.72495257
10SMG12.65685577
11BCR2.48392694
12ERN12.38382031
13WNK12.36834222
14MAPKAPK52.33045964
15PKN12.29602841
16RIPK42.25627022
17FGFR22.11182713
18UHMK12.10389706
19CDK122.10321760
20MET2.09790860
21LIMK12.08826982
22ICK2.07732917
23PBK2.01172185
24NTRK11.93702190
25TAOK21.82732075
26PNCK1.82612233
27EPHA41.77345209
28CSNK1G31.77134093
29MAP3K141.76802675
30CSNK1A1L1.74349206
31PAK61.62916704
32RIPK11.62363708
33TNIK1.60025119
34PRKD31.59905867
35NEK61.58024793
36CAMK2B1.56596340
37PRPF4B1.50842972
38TESK21.49373392
39CSNK1G21.44022156
40CAMK1D1.43599303
41BRAF1.36328755
42LATS21.35508004
43ROCK21.34892235
44MARK11.31948196
45CAMK2D1.28435602
46IRAK41.28256769
47CSNK1G11.28082289
48CLK11.27053424
49FGFR41.26397397
50PIM21.25358894
51DDR21.24406679
52MAPK151.23267241
53BLK1.22625517
54MAP2K31.17079317
55PDGFRA1.16148548
56MAPK121.15815568
57TYK21.15800682
58SIK11.14233636
59MARK21.13559996
60CDK141.12036468
61TYRO31.11790420
62SGK2231.10712710
63SGK4941.10712710
64CDC42BPA1.10253419
65FGR1.08468606
66MAP3K31.06762247
67PAK31.05795536
68CDK51.04371576
69TBK11.04264562
70MST41.03450293
71SIK21.02778290
72KSR21.00116267
73CAMK2G0.99944759
74CDK150.99798943
75MAP3K110.99430186
76MAPK110.95779691
77CDK180.92794566
78CDK11A0.91494464
79CAMKK10.89656784
80MAPKAPK30.88046076
81DYRK20.87136661
82NTRK30.85981310
83ALK0.85588347
84PKN20.85345858
85MAP3K80.84860248
86PRKCQ0.84427283
87TLK10.80738846
88PRKD10.80590505
89PRKCH0.79478524
90CAMK2A0.78626636
91NTRK20.76895737
92PDK20.76550728
93MAP3K20.75929593
94PDPK10.73201261
95MOS0.71869312
96DAPK30.69817276
97HIPK20.69564838
98MTOR0.69133072
99MAP4K10.69017197
100RPS6KA20.67671472
101PHKG20.65641148
102PHKG10.65641148
103TTN0.65387226
104JAK30.64625185
105TAOK10.64521022
106JAK10.63466481
107ABL20.62287609
108IRAK20.62053222
109CDK40.61446236
110ARAF0.60316478
111FYN0.59454838
112STK380.59425164
113ZAP700.58640184
114MAP3K90.58064082
115AKT20.57598076
116MUSK0.55258414
117CSNK1D0.54923987
118STK110.54340949
119TSSK60.54246521
120CASK0.53367135
121WNK30.53126056
122IKBKB0.51148782
123PRKCE0.51044220
124MAP2K20.50833623
125MAP2K60.49844383
126DAPK10.49665669
127ILK0.49067496
128FES0.47295929
129PDK10.45123500
130CAMK40.44934452
131PRKG20.44857645
132MINK10.44571084
133RPS6KC10.44379840
134RPS6KL10.44379840
135PDGFRB0.44162814
136ERBB40.44099293
137TRPM70.43425005
138STK240.43400403
139CSNK1A10.43372377
140PRKD20.42043990
141CAMK1G0.41515820
142CAMKK20.40451841
143NEK90.40315363
144INSRR0.39968930
145PRKG10.38666844
146PAK20.38150528
147ITK0.37193037
148TESK10.37111911
149PAK10.36760629
150PTK20.36126592
151DMPK0.35861230
152DYRK1A0.35491018
153MAP3K10.35270801
154PAK40.34789730
155RPS6KA60.34591908
156RET0.33318614
157MAPK100.32767121
158MAPK40.32247224
159MAPK70.31903280
160PINK10.31790697
161GSK3A0.31470553
162PRKACB0.31108711
163DAPK20.30660922
164RPS6KA50.29773668
165MAP3K130.29706457
166RAF10.29034115
167CSNK1E0.29013439
168CAMK10.27472916
169PTK2B0.26992846
170IRAK10.26431241

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.65424739
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.55576482
3Steroid biosynthesis_Homo sapiens_hsa001003.79187732
4Fatty acid elongation_Homo sapiens_hsa000623.78903369
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.92945819
6Ether lipid metabolism_Homo sapiens_hsa005652.69918406
7Sulfur relay system_Homo sapiens_hsa041222.68174484
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56963018
9Nitrogen metabolism_Homo sapiens_hsa009102.49309617
10Protein export_Homo sapiens_hsa030602.47698420
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22113084
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18985623
13Sulfur metabolism_Homo sapiens_hsa009202.16724281
14Arginine biosynthesis_Homo sapiens_hsa002202.12240047
15Bladder cancer_Homo sapiens_hsa052191.96177619
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91479064
17Other glycan degradation_Homo sapiens_hsa005111.90436893
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83220074
19GABAergic synapse_Homo sapiens_hsa047271.82108982
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78585356
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.76747027
22VEGF signaling pathway_Homo sapiens_hsa043701.75617792
23Sphingolipid metabolism_Homo sapiens_hsa006001.75282883
24Biosynthesis of amino acids_Homo sapiens_hsa012301.74930302
25Vitamin B6 metabolism_Homo sapiens_hsa007501.74753112
26B cell receptor signaling pathway_Homo sapiens_hsa046621.72085007
27Glutamatergic synapse_Homo sapiens_hsa047241.64175022
28Fructose and mannose metabolism_Homo sapiens_hsa000511.58347173
29Phenylalanine metabolism_Homo sapiens_hsa003601.57661853
30Axon guidance_Homo sapiens_hsa043601.56042170
31Linoleic acid metabolism_Homo sapiens_hsa005911.55129908
32Histidine metabolism_Homo sapiens_hsa003401.49310247
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47102500
34TNF signaling pathway_Homo sapiens_hsa046681.45920410
35Morphine addiction_Homo sapiens_hsa050321.43611054
36Cocaine addiction_Homo sapiens_hsa050301.41647235
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.41317602
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37989136
39Oxidative phosphorylation_Homo sapiens_hsa001901.33851626
40Synaptic vesicle cycle_Homo sapiens_hsa047211.33560786
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33324880
42Serotonergic synapse_Homo sapiens_hsa047261.33146612
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32639027
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31716245
45Chronic myeloid leukemia_Homo sapiens_hsa052201.29680878
46Vibrio cholerae infection_Homo sapiens_hsa051101.27199396
47Complement and coagulation cascades_Homo sapiens_hsa046101.26772084
48Osteoclast differentiation_Homo sapiens_hsa043801.26551239
49Circadian entrainment_Homo sapiens_hsa047131.23719069
50Long-term depression_Homo sapiens_hsa047301.22258586
51Acute myeloid leukemia_Homo sapiens_hsa052211.21139298
52Butanoate metabolism_Homo sapiens_hsa006501.19155015
53Renal cell carcinoma_Homo sapiens_hsa052111.18837887
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17933430
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.16859498
56Toxoplasmosis_Homo sapiens_hsa051451.15658665
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.13875750
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.11487550
59Glioma_Homo sapiens_hsa052141.11119296
60Dopaminergic synapse_Homo sapiens_hsa047281.10165483
61Influenza A_Homo sapiens_hsa051641.10052309
62Apoptosis_Homo sapiens_hsa042101.09544395
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08916548
64Insulin secretion_Homo sapiens_hsa049111.08015018
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07734626
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06204260
67Amphetamine addiction_Homo sapiens_hsa050311.06027082
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05382490
69Non-small cell lung cancer_Homo sapiens_hsa052231.01935524
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.01782573
71Alzheimers disease_Homo sapiens_hsa050101.00237079
72PPAR signaling pathway_Homo sapiens_hsa033200.99207982
73Pentose phosphate pathway_Homo sapiens_hsa000300.99108431
74Hepatitis B_Homo sapiens_hsa051610.98827206
75Leishmaniasis_Homo sapiens_hsa051400.98733932
76Collecting duct acid secretion_Homo sapiens_hsa049660.97476333
77Carbon metabolism_Homo sapiens_hsa012000.96559523
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96507411
79Nicotine addiction_Homo sapiens_hsa050330.96202875
80Arginine and proline metabolism_Homo sapiens_hsa003300.95661085
81Phototransduction_Homo sapiens_hsa047440.94867610
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94836092
83Salivary secretion_Homo sapiens_hsa049700.94702377
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.94433200
85Pancreatic secretion_Homo sapiens_hsa049720.94360520
86Tuberculosis_Homo sapiens_hsa051520.94198593
87Cholinergic synapse_Homo sapiens_hsa047250.93647866
88Hepatitis C_Homo sapiens_hsa051600.93549918
89Endocytosis_Homo sapiens_hsa041440.93505755
90Gastric acid secretion_Homo sapiens_hsa049710.93143777
91Pertussis_Homo sapiens_hsa051330.92401027
92Galactose metabolism_Homo sapiens_hsa000520.92334614
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92093786
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.91788168
95Parkinsons disease_Homo sapiens_hsa050120.91427820
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90251210
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86947485
98Long-term potentiation_Homo sapiens_hsa047200.85275317
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84648216
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.84637618
101Tight junction_Homo sapiens_hsa045300.83916853
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82428771
103Insulin signaling pathway_Homo sapiens_hsa049100.80957710
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.80614448
105Dorso-ventral axis formation_Homo sapiens_hsa043200.80308015
106ErbB signaling pathway_Homo sapiens_hsa040120.79549461
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79090707
108Pancreatic cancer_Homo sapiens_hsa052120.78811366
109Measles_Homo sapiens_hsa051620.77724713
110Cardiac muscle contraction_Homo sapiens_hsa042600.77555949
111Shigellosis_Homo sapiens_hsa051310.75204441
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.74523368
113Folate biosynthesis_Homo sapiens_hsa007900.74273549
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.73884502
115One carbon pool by folate_Homo sapiens_hsa006700.72955419
116Lysosome_Homo sapiens_hsa041420.68165522
117Renin secretion_Homo sapiens_hsa049240.66578803
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65930704
119Ras signaling pathway_Homo sapiens_hsa040140.65919259
120GnRH signaling pathway_Homo sapiens_hsa049120.65477741
121Pyruvate metabolism_Homo sapiens_hsa006200.64378153
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64127501
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62926618
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62305808
125Systemic lupus erythematosus_Homo sapiens_hsa053220.61838483
126Gap junction_Homo sapiens_hsa045400.61118770
127Olfactory transduction_Homo sapiens_hsa047400.60848312
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60809695
129Taste transduction_Homo sapiens_hsa047420.60582070
130African trypanosomiasis_Homo sapiens_hsa051430.60435529
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59471972
132Small cell lung cancer_Homo sapiens_hsa052220.59408725
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59332597
134Salmonella infection_Homo sapiens_hsa051320.57324556
135Viral carcinogenesis_Homo sapiens_hsa052030.56519795
136Bile secretion_Homo sapiens_hsa049760.56159371
137cAMP signaling pathway_Homo sapiens_hsa040240.55678710
138Amoebiasis_Homo sapiens_hsa051460.55400093
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54907297
140Herpes simplex infection_Homo sapiens_hsa051680.54507025
141Caffeine metabolism_Homo sapiens_hsa002320.54466685
142Epstein-Barr virus infection_Homo sapiens_hsa051690.54065456
143Staphylococcus aureus infection_Homo sapiens_hsa051500.53559158
144Hedgehog signaling pathway_Homo sapiens_hsa043400.53446951
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52586901
146T cell receptor signaling pathway_Homo sapiens_hsa046600.51640599
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50493424
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49893813
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48878967
150HIF-1 signaling pathway_Homo sapiens_hsa040660.48861430
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.48763709
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48234904
153Fatty acid metabolism_Homo sapiens_hsa012120.46633659
154Ovarian steroidogenesis_Homo sapiens_hsa049130.46341685
155Oxytocin signaling pathway_Homo sapiens_hsa049210.44427785
156Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43970699
157Alcoholism_Homo sapiens_hsa050340.43762060
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43640608
159Choline metabolism in cancer_Homo sapiens_hsa052310.43415255
160Mineral absorption_Homo sapiens_hsa049780.43191283
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.42827283
162Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42631076
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42517122
164Rheumatoid arthritis_Homo sapiens_hsa053230.42412474
165Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42306861
166Prolactin signaling pathway_Homo sapiens_hsa049170.42300801
167Prion diseases_Homo sapiens_hsa050200.39873352
168Glutathione metabolism_Homo sapiens_hsa004800.39183162
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38351502
170Arachidonic acid metabolism_Homo sapiens_hsa005900.38332088
171Fatty acid biosynthesis_Homo sapiens_hsa000610.38295221
172Inositol phosphate metabolism_Homo sapiens_hsa005620.37953900
173Estrogen signaling pathway_Homo sapiens_hsa049150.35743423
174Thyroid hormone synthesis_Homo sapiens_hsa049180.34996073
175Melanogenesis_Homo sapiens_hsa049160.34991527
176Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32563503
177Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30972724
178Calcium signaling pathway_Homo sapiens_hsa040200.29877710
179cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29867894

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