DET1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.89363103
2doxorubicin metabolic process (GO:0044598)8.89363103
3daunorubicin metabolic process (GO:0044597)8.89363103
4regulation of nuclear cell cycle DNA replication (GO:0033262)6.58830189
5behavioral response to nicotine (GO:0035095)5.70276404
6aminoglycoside antibiotic metabolic process (GO:0030647)5.53021918
7rRNA modification (GO:0000154)5.39056997
8rRNA methylation (GO:0031167)5.31607278
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.71464778
10regulation of telomere maintenance via telomerase (GO:0032210)4.68511813
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.43872918
12DNA replication checkpoint (GO:0000076)4.41990601
13negative regulation of telomerase activity (GO:0051974)4.39097116
14positive regulation of DNA-dependent DNA replication (GO:2000105)4.36276485
15pseudouridine synthesis (GO:0001522)4.34733296
16protein localization to kinetochore (GO:0034501)4.29716984
17histone H4-K12 acetylation (GO:0043983)4.28932986
18maintenance of protein location in nucleus (GO:0051457)4.28821817
19negative regulation of telomere maintenance (GO:0032205)4.19066210
20DNA deamination (GO:0045006)4.16368205
21interferon-gamma production (GO:0032609)4.10948101
22regulation of translation in response to stress (GO:0043555)4.09249979
23negative regulation of epidermis development (GO:0045683)4.07478053
24somite rostral/caudal axis specification (GO:0032525)4.04695211
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.04311668
26ribosome biogenesis (GO:0042254)4.03125666
27rRNA transcription (GO:0009303)4.02863296
28DNA damage response, detection of DNA damage (GO:0042769)4.00180109
29negative regulation of cell cycle G2/M phase transition (GO:1902750)3.92903028
30piRNA metabolic process (GO:0034587)3.91781160
31pyrimidine nucleobase catabolic process (GO:0006208)3.85280006
32regulation of response to osmotic stress (GO:0047484)3.80919605
33regulation of MHC class I biosynthetic process (GO:0045343)3.76143875
34epithelial cilium movement (GO:0003351)3.72733883
35histone H4-K8 acetylation (GO:0043982)3.69984805
36histone H4-K5 acetylation (GO:0043981)3.69984805
37ribosomal small subunit biogenesis (GO:0042274)3.68736201
38quinone metabolic process (GO:1901661)3.68036002
39response to pheromone (GO:0019236)3.67123983
40L-fucose catabolic process (GO:0042355)3.66649923
41fucose catabolic process (GO:0019317)3.66649923
42L-fucose metabolic process (GO:0042354)3.66649923
43somite development (GO:0061053)3.62289012
44negative regulation of epidermal cell differentiation (GO:0045605)3.61480867
45mitotic sister chromatid segregation (GO:0000070)3.60706399
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.60258179
47protein polyglutamylation (GO:0018095)3.57868584
48protein localization to cilium (GO:0061512)3.57567049
49ribonucleoprotein complex biogenesis (GO:0022613)3.55202680
50neural tube formation (GO:0001841)3.54210144
51intraciliary transport (GO:0042073)3.49564736
52protein localization to chromosome, centromeric region (GO:0071459)3.49036179
53GDP-mannose metabolic process (GO:0019673)3.45749533
54DNA double-strand break processing (GO:0000729)3.40978824
55DNA replication initiation (GO:0006270)3.37570924
56regulation of cilium movement (GO:0003352)3.37511327
57nucleoside transmembrane transport (GO:1901642)3.34551431
58regulation of DNA-dependent DNA replication (GO:0090329)3.29376630
59DNA methylation involved in gamete generation (GO:0043046)3.26765860
60protein-cofactor linkage (GO:0018065)3.25493872
61negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.25311439
62synaptic transmission, cholinergic (GO:0007271)3.24884353
63DNA replication-dependent nucleosome organization (GO:0034723)3.21875235
64DNA replication-dependent nucleosome assembly (GO:0006335)3.21875235
65protein complex biogenesis (GO:0070271)3.21307864
66cullin deneddylation (GO:0010388)3.21025735
67cilium morphogenesis (GO:0060271)3.20477174
68regulation of telomere maintenance (GO:0032204)3.19505629
69regulation of action potential (GO:0098900)3.18257443
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17625812
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.17625812
72NADH dehydrogenase complex assembly (GO:0010257)3.17625812
73cilium organization (GO:0044782)3.15045121
74RNA methylation (GO:0001510)3.13954178
75regulation of telomerase activity (GO:0051972)3.12922945
76muscle organ morphogenesis (GO:0048644)3.12374236
77nucleobase catabolic process (GO:0046113)3.11993356
78preassembly of GPI anchor in ER membrane (GO:0016254)3.10735075
79indolalkylamine metabolic process (GO:0006586)3.10628209
80axoneme assembly (GO:0035082)3.10217476
81positive regulation of oligodendrocyte differentiation (GO:0048714)3.09856993
82telomere maintenance via semi-conservative replication (GO:0032201)3.09185219
83mitochondrial DNA replication (GO:0006264)3.08467636
84cilium assembly (GO:0042384)3.08077588
85platelet dense granule organization (GO:0060155)3.06862159
86protein deneddylation (GO:0000338)3.06473769
87cilium movement (GO:0003341)3.05287107
88water-soluble vitamin biosynthetic process (GO:0042364)3.05183055
89mitochondrial respiratory chain complex assembly (GO:0033108)2.99973989
90cellular component biogenesis (GO:0044085)2.98431917
91formation of translation preinitiation complex (GO:0001731)2.97312332
92nonmotile primary cilium assembly (GO:0035058)2.95576474
93limb bud formation (GO:0060174)2.95370686
94transcription from RNA polymerase I promoter (GO:0006360)2.92736665
95notochord development (GO:0030903)2.91608493
96cytidine metabolic process (GO:0046087)2.91239403
97cytidine catabolic process (GO:0006216)2.91239403
98cytidine deamination (GO:0009972)2.91239403
99termination of RNA polymerase III transcription (GO:0006386)2.89493582
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.89493582
101tRNA methylation (GO:0030488)2.89294933
102DNA strand elongation involved in DNA replication (GO:0006271)2.89228837
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89191894
104cilium or flagellum-dependent cell motility (GO:0001539)2.87662549
105regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85873275
106head development (GO:0060322)2.85156333
107detection of light stimulus involved in visual perception (GO:0050908)2.84689563
108detection of light stimulus involved in sensory perception (GO:0050962)2.84689563
109regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.83316892
110DNA strand elongation (GO:0022616)2.81381358
111DNA integration (GO:0015074)2.79317535
112kynurenine metabolic process (GO:0070189)2.78620483
113cornea development in camera-type eye (GO:0061303)2.77804023
114proteasome assembly (GO:0043248)2.77496200
115synapsis (GO:0007129)2.76790546
116retinal cone cell development (GO:0046549)2.76707043
117ubiquinone biosynthetic process (GO:0006744)2.76266892
118positive regulation of defense response to virus by host (GO:0002230)2.75920547
119rRNA processing (GO:0006364)2.75775849
120regulation of double-strand break repair (GO:2000779)2.75681800
121mitotic G2/M transition checkpoint (GO:0044818)2.74922780
122RNA modification (GO:0009451)2.74190117
123sister chromatid segregation (GO:0000819)2.73970686
124male meiosis I (GO:0007141)2.73280730
125hindbrain development (GO:0030902)2.70839824
126indole-containing compound catabolic process (GO:0042436)2.70815207
127indolalkylamine catabolic process (GO:0046218)2.70815207
128tryptophan catabolic process (GO:0006569)2.70815207
129nucleoside transport (GO:0015858)2.69095554
130replication fork processing (GO:0031297)2.68832532
131negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.68542022
132negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67750550
133ubiquinone metabolic process (GO:0006743)2.66169070
134postsynaptic membrane organization (GO:0001941)2.66124439
135rRNA metabolic process (GO:0016072)2.65959841
136organelle disassembly (GO:1903008)2.65946251
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64338546
138telomere maintenance via recombination (GO:0000722)2.63332063
139reciprocal DNA recombination (GO:0035825)2.61464489
140reciprocal meiotic recombination (GO:0007131)2.61464489
141centriole assembly (GO:0098534)2.61419248
142primitive streak formation (GO:0090009)2.58910769
143photoreceptor cell development (GO:0042461)2.58789439
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.58531526
145retinal ganglion cell axon guidance (GO:0031290)2.57257136
146resolution of meiotic recombination intermediates (GO:0000712)2.56958252
147mitotic recombination (GO:0006312)2.56188940
148regulation of meiosis I (GO:0060631)2.56182800
149GPI anchor metabolic process (GO:0006505)2.56169847
150cellular ketone body metabolic process (GO:0046950)2.56123203
151respiratory chain complex IV assembly (GO:0008535)2.55394443
152kidney morphogenesis (GO:0060993)2.55328223
153DNA duplex unwinding (GO:0032508)2.55022096
154phenol-containing compound catabolic process (GO:0019336)2.54897970
155nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54880671
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54035057
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53839754
158smoothened signaling pathway (GO:0007224)2.53528391
159histone H4-K16 acetylation (GO:0043984)2.53310493
160photoreceptor cell maintenance (GO:0045494)2.53205387
161male meiosis (GO:0007140)2.53156772
162DNA geometric change (GO:0032392)2.53073144
163DNA-dependent DNA replication (GO:0006261)2.52812296
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52660316
165dopamine transport (GO:0015872)2.52372915
166neuronal action potential (GO:0019228)2.52209104
167ribosomal small subunit assembly (GO:0000028)2.51507640
168neuron fate determination (GO:0048664)2.51228784
169tRNA modification (GO:0006400)2.47889095
170telomere maintenance via telomere lengthening (GO:0010833)2.47441237
171maturation of SSU-rRNA (GO:0030490)2.46533176
172recombinational repair (GO:0000725)2.45707563
173behavioral response to ethanol (GO:0048149)2.45017969
174centriole replication (GO:0007099)2.44574933
175spindle assembly (GO:0051225)2.44472784
176negative regulation of interleukin-2 production (GO:0032703)2.44448164
177DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.44427311
178olfactory bulb development (GO:0021772)2.44039952
179nuclear pore complex assembly (GO:0051292)2.43861771
180maturation of 5.8S rRNA (GO:0000460)2.43269353
181presynaptic membrane assembly (GO:0097105)2.42908653
182cellular component assembly involved in morphogenesis (GO:0010927)2.42105850
183gamma-aminobutyric acid transport (GO:0015812)2.41754783
184double-strand break repair via homologous recombination (GO:0000724)2.41365450
185glycerophospholipid catabolic process (GO:0046475)2.41250153
186spinal cord motor neuron differentiation (GO:0021522)2.39667388
187glycosphingolipid biosynthetic process (GO:0006688)2.39467160
188C-terminal protein amino acid modification (GO:0018410)2.39221308
189adaptation of signaling pathway (GO:0023058)2.38412280
190tryptophan metabolic process (GO:0006568)2.37845633
191anterograde synaptic vesicle transport (GO:0048490)2.35974115
192ketone body metabolic process (GO:1902224)2.34680880
193regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34655741
194negative regulation of axon guidance (GO:1902668)2.34062158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.14452599
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.62573765
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.03666962
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.25329441
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.25329441
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.25329441
7ZNF274_21170338_ChIP-Seq_K562_Hela3.86707914
8EZH2_22144423_ChIP-Seq_EOC_Human3.75321110
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.31355218
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28215061
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25725743
12VDR_22108803_ChIP-Seq_LS180_Human3.18759474
13GBX2_23144817_ChIP-Seq_PC3_Human3.17658883
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.09300961
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64732991
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.63973195
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63929351
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61043744
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57784204
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55609154
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45269501
22* NOTCH1_21737748_ChIP-Seq_TLL_Human2.39034490
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.37067458
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33577725
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33412661
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.32943440
27FUS_26573619_Chip-Seq_HEK293_Human2.32680470
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30646719
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30596687
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29743876
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29415456
32EWS_26573619_Chip-Seq_HEK293_Human2.22265145
33TAF15_26573619_Chip-Seq_HEK293_Human2.22072087
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.18824359
35* ETS1_20019798_ChIP-Seq_JURKAT_Human2.18813724
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13580576
37CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10770214
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08254952
39P300_19829295_ChIP-Seq_ESCs_Human2.07894990
40CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05835632
41IRF1_19129219_ChIP-ChIP_H3396_Human2.01908853
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99171249
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98179772
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97536994
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.96958148
46FOXP3_21729870_ChIP-Seq_TREG_Human1.95101581
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94692061
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94089637
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.92600921
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89855221
51* VDR_23849224_ChIP-Seq_CD4+_Human1.86888090
52ER_23166858_ChIP-Seq_MCF-7_Human1.84346662
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78012654
54NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.77635187
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73526600
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71627455
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69763623
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66665318
59* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65776040
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.63590589
61BCAT_22108803_ChIP-Seq_LS180_Human1.62988179
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62576951
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62399071
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60304186
65SMAD4_21799915_ChIP-Seq_A2780_Human1.59162802
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56765776
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.55324481
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54693320
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54663039
70CBP_20019798_ChIP-Seq_JUKART_Human1.53435908
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53435908
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52708349
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50497206
74STAT3_23295773_ChIP-Seq_U87_Human1.50369518
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49590132
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48232846
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48082970
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43411472
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43411472
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43262469
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.42835421
82SCL_19346495_ChIP-Seq_HPC-7_Human1.42367388
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42024747
84* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41527429
85AR_25329375_ChIP-Seq_VCAP_Human1.41332466
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41236583
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40911315
88RNF2_27304074_Chip-Seq_NSC_Mouse1.39625483
89TP53_22573176_ChIP-Seq_HFKS_Human1.36772319
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36555719
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36181468
92* TCF4_23295773_ChIP-Seq_U87_Human1.36126654
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33723312
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31979615
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31485710
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30899558
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30894604
98CIITA_25753668_ChIP-Seq_RAJI_Human1.30088004
99* TTF2_22483619_ChIP-Seq_HELA_Human1.29966218
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28835286
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28813917
102XRN2_22483619_ChIP-Seq_HELA_Human1.28487780
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28151545
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26598367
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.26021295
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25969353
107TCF4_22108803_ChIP-Seq_LS180_Human1.24618467
108ELK1_19687146_ChIP-ChIP_HELA_Human1.23936585
109RUNX2_22187159_ChIP-Seq_PCA_Human1.23399077
110* GABP_19822575_ChIP-Seq_HepG2_Human1.22119517
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22091870
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20561393
113SOX2_19829295_ChIP-Seq_ESCs_Human1.20259781
114NANOG_19829295_ChIP-Seq_ESCs_Human1.20259781
115REST_21632747_ChIP-Seq_MESCs_Mouse1.20052495
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18243109
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.17967572
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17600108
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.17261628
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15800598
121DCP1A_22483619_ChIP-Seq_HELA_Human1.15086509
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13982538
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13487860
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13157918
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11925698
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11595332
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09842926
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08045747
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07252430
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07129645
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06789011
132* SPI1_23547873_ChIP-Seq_NB4_Human1.06050634
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.04451943
134ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04176717
135FOXA1_25329375_ChIP-Seq_VCAP_Human1.03982931
136FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03982931
137* NCOR_22424771_ChIP-Seq_293T_Human1.03739970
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03455640
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03240785
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03208039
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03182438
142FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02511860
143ELK1_22589737_ChIP-Seq_MCF10A_Human1.01901213
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00932659
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00455132
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.00220723
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.00089115
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00005688
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98716637
150KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98435217
151AR_21572438_ChIP-Seq_LNCaP_Human0.98238608
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.98006144
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.97500841
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96990965
155GATA3_21878914_ChIP-Seq_MCF-7_Human0.96750365
156* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96626311
157AR_20517297_ChIP-Seq_VCAP_Human0.96530292
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96240350
159* JUN_21703547_ChIP-Seq_K562_Human0.95856317
160MYC_18940864_ChIP-ChIP_HL60_Human0.95771105
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95660476
162TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94745844
163P53_22387025_ChIP-Seq_ESCs_Mouse0.94005024
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.93927018
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92575509
166KDM5A_27292631_Chip-Seq_BREAST_Human0.90866469
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90670599
168FLI1_27457419_Chip-Seq_LIVER_Mouse0.89971645
169E2F1_21310950_ChIP-Seq_MCF-7_Human0.87140352
170NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84468748
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84270537
172PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83476652
173E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82016364
174CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81362100
175IGF1R_20145208_ChIP-Seq_DFB_Human0.80817511
176PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79496264
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.79479509
178* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79213508
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78470169
180* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76386971
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75951991
182SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74813789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.52138155
2MP0002102_abnormal_ear_morphology4.36523513
3MP0008057_abnormal_DNA_replication4.29072462
4MP0005075_abnormal_melanosome_morpholog3.90242332
5MP0003011_delayed_dark_adaptation3.16761221
6MP0008877_abnormal_DNA_methylation2.96554230
7MP0004957_abnormal_blastocyst_morpholog2.90817422
8MP0005394_taste/olfaction_phenotype2.83430228
9MP0005499_abnormal_olfactory_system2.83430228
10MP0003111_abnormal_nucleus_morphology2.63713706
11MP0008058_abnormal_DNA_repair2.61068587
12MP0002396_abnormal_hematopoietic_system2.56586388
13MP0002132_abnormal_respiratory_system2.54903832
14MP0002638_abnormal_pupillary_reflex2.39937373
15MP0003077_abnormal_cell_cycle2.38303906
16MP0010094_abnormal_chromosome_stability2.38302011
17MP0003880_abnormal_central_pattern2.35670589
18MP0003693_abnormal_embryo_hatching2.35458060
19MP0002234_abnormal_pharynx_morphology2.32697314
20MP0003890_abnormal_embryonic-extraembry2.28667660
21MP0002277_abnormal_respiratory_mucosa2.23607932
22MP0006276_abnormal_autonomic_nervous2.22078767
23MP0004264_abnormal_extraembryonic_tissu2.18185898
24MP0004381_abnormal_hair_follicle2.15286401
25MP0002837_dystrophic_cardiac_calcinosis2.09240543
26MP0005551_abnormal_eye_electrophysiolog2.07645476
27MP0003646_muscle_fatigue2.06428533
28MP0003195_calcinosis2.05187725
29MP0000678_abnormal_parathyroid_gland2.03433886
30MP0001529_abnormal_vocalization1.97649631
31MP0006072_abnormal_retinal_apoptosis1.97139378
32MP0008007_abnormal_cellular_replicative1.91522895
33MP0005646_abnormal_pituitary_gland1.91495332
34MP0004142_abnormal_muscle_tone1.86832757
35MP0000569_abnormal_digit_pigmentation1.86409973
36MP0000490_abnormal_crypts_of1.76881847
37MP0008789_abnormal_olfactory_epithelium1.75038209
38MP0005253_abnormal_eye_physiology1.74759340
39MP0005257_abnormal_intraocular_pressure1.73966175
40MP0003283_abnormal_digestive_organ1.72569928
41MP0003786_premature_aging1.71910820
42MP0001984_abnormal_olfaction1.71104138
43MP0004133_heterotaxia1.68402214
44MP0003121_genomic_imprinting1.68158230
45MP0003938_abnormal_ear_development1.67472092
46MP0002254_reproductive_system_inflammat1.66953056
47MP0003136_yellow_coat_color1.65958039
48MP0006035_abnormal_mitochondrial_morpho1.64840879
49MP0009046_muscle_twitch1.64305978
50MP0004145_abnormal_muscle_electrophysio1.63164033
51MP0002332_abnormal_exercise_endurance1.56535285
52MP0000631_abnormal_neuroendocrine_gland1.56318852
53MP0002272_abnormal_nervous_system1.52672463
54MP0005671_abnormal_response_to1.50637606
55MP0000049_abnormal_middle_ear1.50403660
56MP0000778_abnormal_nervous_system1.46787199
57MP0001968_abnormal_touch/_nociception1.42730884
58MP0001188_hyperpigmentation1.42250665
59MP0008932_abnormal_embryonic_tissue1.41319849
60MP0000427_abnormal_hair_cycle1.40411302
61MP0008995_early_reproductive_senescence1.37718192
62MP0009745_abnormal_behavioral_response1.37640677
63MP0001485_abnormal_pinna_reflex1.35533054
64MP0003315_abnormal_perineum_morphology1.34317722
65MP0010386_abnormal_urinary_bladder1.31854100
66MP0001486_abnormal_startle_reflex1.31137348
67MP0001835_abnormal_antigen_presentation1.29044291
68MP0003122_maternal_imprinting1.28537446
69MP0005084_abnormal_gallbladder_morpholo1.28176261
70MP0002822_catalepsy1.28064274
71MP0003763_abnormal_thymus_physiology1.22595261
72MP0004043_abnormal_pH_regulation1.22139595
73MP0000350_abnormal_cell_proliferation1.20738710
74MP0000383_abnormal_hair_follicle1.19337319
75MP0001672_abnormal_embryogenesis/_devel1.19197104
76MP0005380_embryogenesis_phenotype1.19197104
77MP0001293_anophthalmia1.18413197
78MP0001501_abnormal_sleep_pattern1.18381469
79MP0008872_abnormal_physiological_respon1.17982416
80MP0004147_increased_porphyrin_level1.17572052
81MP0000313_abnormal_cell_death1.17400618
82MP0002160_abnormal_reproductive_system1.15792733
83MP0005645_abnormal_hypothalamus_physiol1.13891304
84MP0000372_irregular_coat_pigmentation1.13749423
85MP0006082_CNS_inflammation1.13674811
86MP0002557_abnormal_social/conspecific_i1.10942612
87MP0003787_abnormal_imprinting1.10847533
88MP0002722_abnormal_immune_system1.10470716
89MP0000689_abnormal_spleen_morphology1.09188545
90MP0002127_abnormal_cardiovascular_syste1.07637515
91MP0002398_abnormal_bone_marrow1.05757503
92MP0002572_abnormal_emotion/affect_behav1.04800037
93MP0002735_abnormal_chemical_nociception1.04576370
94MP0002653_abnormal_ependyma_morphology1.04541951
95MP0002928_abnormal_bile_duct1.04540721
96MP0001800_abnormal_humoral_immune1.03692651
97MP0003937_abnormal_limbs/digits/tail_de1.03534669
98MP0009785_altered_susceptibility_to1.02049091
99MP0002736_abnormal_nociception_after1.01926255
100MP0000762_abnormal_tongue_morphology1.01252215
101MP0002088_abnormal_embryonic_growth/wei1.00949046
102MP0003984_embryonic_growth_retardation1.00749102
103MP0002752_abnormal_somatic_nervous0.99614214
104MP0005195_abnormal_posterior_eye0.99202018
105MP0000703_abnormal_thymus_morphology0.98752795
106MP0002184_abnormal_innervation0.98277831
107MP0004215_abnormal_myocardial_fiber0.97660811
108MP0002876_abnormal_thyroid_physiology0.97208931
109MP0005386_behavior/neurological_phenoty0.97205883
110MP0004924_abnormal_behavior0.97205883
111MP0000026_abnormal_inner_ear0.96376681
112MP0005389_reproductive_system_phenotype0.96232920
113MP0001929_abnormal_gametogenesis0.94949655
114MP0002932_abnormal_joint_morphology0.94616718
115MP0002064_seizures0.94070265
116MP0002063_abnormal_learning/memory/cond0.93840204
117MP0002019_abnormal_tumor_incidence0.93796649
118MP0005174_abnormal_tail_pigmentation0.93410955
119MP0003635_abnormal_synaptic_transmissio0.93043936
120MP0003698_abnormal_male_reproductive0.92721199
121MP0002938_white_spotting0.91043901
122MP0000716_abnormal_immune_system0.90298087
123MP0002233_abnormal_nose_morphology0.90087223
124MP0003718_maternal_effect0.90070089
125MP0002429_abnormal_blood_cell0.89857463
126MP0000015_abnormal_ear_pigmentation0.88779878
127MP0005187_abnormal_penis_morphology0.88755179
128MP0002067_abnormal_sensory_capabilities0.88510012
129MP0002249_abnormal_larynx_morphology0.88118869
130MP0001986_abnormal_taste_sensitivity0.88098530
131MP0005266_abnormal_metabolism0.87603433
132MP0001970_abnormal_pain_threshold0.87517579
133MP0002114_abnormal_axial_skeleton0.87188723
134MP0005025_abnormal_response_to0.86820980
135MP0003119_abnormal_digestive_system0.86316249
136MP0002751_abnormal_autonomic_nervous0.86116412
137MP0002420_abnormal_adaptive_immunity0.84502348
138MP0001905_abnormal_dopamine_level0.83956769
139MP0000653_abnormal_sex_gland0.83571033
140MP0005000_abnormal_immune_tolerance0.83494985
141MP0001819_abnormal_immune_cell0.83386817
142MP0009333_abnormal_splenocyte_physiolog0.82863954
143MP0002085_abnormal_embryonic_tissue0.82225760
144MP0009379_abnormal_foot_pigmentation0.81882069
145MP0004885_abnormal_endolymph0.81691175
146MP0002723_abnormal_immune_serum0.81410039
147MP0001764_abnormal_homeostasis0.81259696
148MP0002733_abnormal_thermal_nociception0.80283328
149MP0001324_abnormal_eye_pigmentation0.79876516
150MP0006036_abnormal_mitochondrial_physio0.79752615
151MP0003186_abnormal_redox_activity0.79120920
152MP0003567_abnormal_fetal_cardiomyocyte0.79099281
153MP0004085_abnormal_heartbeat0.78511793
154MP0002282_abnormal_trachea_morphology0.78400778
155MP0001502_abnormal_circadian_rhythm0.78151882
156MP0000613_abnormal_salivary_gland0.78108996
157MP0002092_abnormal_eye_morphology0.77782426
158MP0003828_pulmonary_edema0.77717032
159MP0000955_abnormal_spinal_cord0.77061986
160MP0002095_abnormal_skin_pigmentation0.76660379
161MP0010030_abnormal_orbit_morphology0.76146856
162MP0002452_abnormal_antigen_presenting0.75674190
163MP0001853_heart_inflammation0.75578904
164MP0001790_abnormal_immune_system0.74699064
165MP0005387_immune_system_phenotype0.74699064
166MP0002405_respiratory_system_inflammati0.73294839
167MP0002075_abnormal_coat/hair_pigmentati0.73233082
168MP0002148_abnormal_hypersensitivity_rea0.71238412
169MP0003123_paternal_imprinting0.70060972
170MP0001145_abnormal_male_reproductive0.69721111
171MP0002210_abnormal_sex_determination0.69484716
172MP0000566_synostosis0.68323208
173MP0000858_altered_metastatic_potential0.67955900
174MP0005391_vision/eye_phenotype0.67367342
175MP0001186_pigmentation_phenotype0.67366620

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.65557006
2Chromsome breakage (HP:0040012)4.98903337
3Bilateral microphthalmos (HP:0007633)4.69824840
4Pancreatic cysts (HP:0001737)4.56740824
5Pancreatic fibrosis (HP:0100732)4.50209959
6Hypochromic microcytic anemia (HP:0004840)4.32136443
7True hermaphroditism (HP:0010459)4.18951813
8Abnormality of midbrain morphology (HP:0002418)4.18610734
9Molar tooth sign on MRI (HP:0002419)4.18610734
10Reduced antithrombin III activity (HP:0001976)3.77243798
11Nephronophthisis (HP:0000090)3.71728300
12Chronic hepatic failure (HP:0100626)3.55140617
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.54875476
14Hypoplasia of the fovea (HP:0007750)3.54875476
15Rib fusion (HP:0000902)3.37973771
16Nephroblastoma (Wilms tumor) (HP:0002667)3.37489804
17Medial flaring of the eyebrow (HP:0010747)3.34581762
183-Methylglutaconic aciduria (HP:0003535)3.26371704
19Meckel diverticulum (HP:0002245)3.24995576
20Abnormality of the renal medulla (HP:0100957)3.23838151
21Type I transferrin isoform profile (HP:0003642)3.22246817
22Abnormality of the renal cortex (HP:0011035)3.18133000
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.14297246
24Embryonal renal neoplasm (HP:0011794)3.09987773
25Abnormality of the ileum (HP:0001549)3.09851671
26Cystic liver disease (HP:0006706)3.04538047
27Multiple enchondromatosis (HP:0005701)3.00869978
28Testicular atrophy (HP:0000029)2.99628884
29Short middle phalanx of the 5th finger (HP:0004220)2.99591179
30Abnormal lung lobation (HP:0002101)2.91067996
31Type II lissencephaly (HP:0007260)2.89870654
32Aplastic anemia (HP:0001915)2.89804465
33Progressive external ophthalmoplegia (HP:0000590)2.89247409
34Rectovaginal fistula (HP:0000143)2.85580665
35Rectal fistula (HP:0100590)2.85580665
36Abnormality of the preputium (HP:0100587)2.79281356
37Congenital stationary night blindness (HP:0007642)2.77498096
38Lissencephaly (HP:0001339)2.76108739
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75570016
40Gait imbalance (HP:0002141)2.72639172
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.71460220
42Abnormality of the labia minora (HP:0012880)2.71111271
43Partial duplication of thumb phalanx (HP:0009944)2.68962198
44Congenital primary aphakia (HP:0007707)2.68043294
45Abnormality of the fovea (HP:0000493)2.67530714
46Microvesicular hepatic steatosis (HP:0001414)2.66814556
47Anomalous pulmonary venous return (HP:0010772)2.66741384
48Tubular atrophy (HP:0000092)2.64267226
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63069108
50Renal cortical cysts (HP:0000803)2.59708329
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58949736
52Sclerocornea (HP:0000647)2.57648305
53Hypochromic anemia (HP:0001931)2.56646485
54Cheilitis (HP:0100825)2.55507250
55Postaxial foot polydactyly (HP:0001830)2.53861740
56Progressive muscle weakness (HP:0003323)2.53837098
57Nephrogenic diabetes insipidus (HP:0009806)2.50627456
58Intestinal fistula (HP:0100819)2.50012459
59Pendular nystagmus (HP:0012043)2.46912727
60Nasolacrimal duct obstruction (HP:0000579)2.45018346
61Anencephaly (HP:0002323)2.42883151
62Abolished electroretinogram (ERG) (HP:0000550)2.42096535
63Oligodactyly (hands) (HP:0001180)2.41510631
64Impulsivity (HP:0100710)2.41320700
65Attenuation of retinal blood vessels (HP:0007843)2.40503470
66Amyotrophic lateral sclerosis (HP:0007354)2.40370493
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.40206406
68Myelodysplasia (HP:0002863)2.38438300
69Duodenal stenosis (HP:0100867)2.38269372
70Small intestinal stenosis (HP:0012848)2.38269372
71Duplication of thumb phalanx (HP:0009942)2.37931952
72Hepatoblastoma (HP:0002884)2.37812635
73Vaginal fistula (HP:0004320)2.37763464
74Bifid tongue (HP:0010297)2.37328360
75Rhabdomyosarcoma (HP:0002859)2.36806535
76Occipital encephalocele (HP:0002085)2.36457823
77Pachygyria (HP:0001302)2.35778551
78Absent/shortened dynein arms (HP:0200106)2.32690492
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.32690492
80Abnormality of the prostate (HP:0008775)2.32492507
81Microretrognathia (HP:0000308)2.31456542
82Bone marrow hypocellularity (HP:0005528)2.30956338
83Abnormality of chromosome stability (HP:0003220)2.30234759
84Sparse eyelashes (HP:0000653)2.29865192
85Ependymoma (HP:0002888)2.28319812
86Congenital hepatic fibrosis (HP:0002612)2.27584035
87Acute necrotizing encephalopathy (HP:0006965)2.24785307
88Abnormal rod and cone electroretinograms (HP:0008323)2.24101469
89Supernumerary spleens (HP:0009799)2.23635241
90Abnormal respiratory epithelium morphology (HP:0012253)2.23607362
91Abnormal respiratory motile cilium morphology (HP:0005938)2.23607362
92Limb dystonia (HP:0002451)2.23315795
93Genital tract atresia (HP:0001827)2.22351393
94Partial duplication of the phalanx of hand (HP:0009999)2.20242858
95Abnormal number of erythroid precursors (HP:0012131)2.19396762
96Combined immunodeficiency (HP:0005387)2.19037367
97Abnormality of the pulmonary veins (HP:0011718)2.18973336
98Sloping forehead (HP:0000340)2.18167767
99Postaxial hand polydactyly (HP:0001162)2.17601319
100Preaxial hand polydactyly (HP:0001177)2.15707084
101Abnormality of the renal collecting system (HP:0004742)2.15286697
102Trismus (HP:0000211)2.14158048
103Retinal dysplasia (HP:0007973)2.12439989
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12038293
105Polydipsia (HP:0001959)2.11563478
106Abnormal drinking behavior (HP:0030082)2.11563478
107Male pseudohermaphroditism (HP:0000037)2.11459244
108Abnormal ciliary motility (HP:0012262)2.11157877
109Neoplasm of striated muscle (HP:0009728)2.11084750
110Reticulocytopenia (HP:0001896)2.10354092
111Cerebellar dysplasia (HP:0007033)2.09100795
112Broad-based gait (HP:0002136)2.08367941
113Ragged-red muscle fibers (HP:0003200)2.07860774
114Vaginal atresia (HP:0000148)2.07647342
115Birth length less than 3rd percentile (HP:0003561)2.07526000
116Triphalangeal thumb (HP:0001199)2.06213485
117Duplicated collecting system (HP:0000081)2.05630223
118Facial cleft (HP:0002006)2.04185708
119Abnormality of cells of the erythroid lineage (HP:0012130)2.04090215
120Mitochondrial inheritance (HP:0001427)2.03973075
121Volvulus (HP:0002580)2.02735819
122Acute encephalopathy (HP:0006846)2.02625200
123Hypothermia (HP:0002045)2.01651875
124Clubbing of toes (HP:0100760)2.01510148
125Supernumerary bones of the axial skeleton (HP:0009144)2.01437486
126Short tibia (HP:0005736)2.01393401
127Abnormal protein glycosylation (HP:0012346)2.00317079
128Abnormal glycosylation (HP:0012345)2.00317079
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00317079
130Abnormal protein N-linked glycosylation (HP:0012347)2.00317079
131Increased CSF lactate (HP:0002490)2.00108448
132Progressive macrocephaly (HP:0004481)1.99770179
133Supernumerary ribs (HP:0005815)1.98753947
134Aplasia/Hypoplasia of the macula (HP:0008059)1.98751509
135Short 5th finger (HP:0009237)1.98456306
136Prostate neoplasm (HP:0100787)1.98436640
137Colon cancer (HP:0003003)1.98248056
138Gaze-evoked nystagmus (HP:0000640)1.98031560
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.97372300
140Embryonal neoplasm (HP:0002898)1.96931346
141Hepatocellular necrosis (HP:0001404)1.96845764
142Type 2 muscle fiber atrophy (HP:0003554)1.96641536
143Narrow forehead (HP:0000341)1.96508547
144Febrile seizures (HP:0002373)1.95523143
145Abnormal mitochondria in muscle tissue (HP:0008316)1.95510238
146Optic nerve hypoplasia (HP:0000609)1.94900877
147Large for gestational age (HP:0001520)1.94791769
148Progressive cerebellar ataxia (HP:0002073)1.94259344
149Abnormality of the duodenum (HP:0002246)1.93703407
150Dandy-Walker malformation (HP:0001305)1.93619583
151Inability to walk (HP:0002540)1.93612026
152Drooling (HP:0002307)1.93432134
153Hepatic necrosis (HP:0002605)1.93386403
154Pancytopenia (HP:0001876)1.91036094
155Progressive inability to walk (HP:0002505)1.90569549
156Anophthalmia (HP:0000528)1.89700529
157Intestinal atresia (HP:0011100)1.89140565
158Poor coordination (HP:0002370)1.88271983
159Periauricular skin pits (HP:0100277)1.88157527
160Preauricular pit (HP:0004467)1.88157527
161Thyroid-stimulating hormone excess (HP:0002925)1.87986159
162IgM deficiency (HP:0002850)1.86988588
163Patellar aplasia (HP:0006443)1.86734366
164Abnormal biliary tract physiology (HP:0012439)1.85727644
165Bile duct proliferation (HP:0001408)1.85727644
166Abnormality of the salivary glands (HP:0010286)1.85237097
167Furrowed tongue (HP:0000221)1.85050243
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.84596366
169Hyperventilation (HP:0002883)1.84438646
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83982168
171Specific learning disability (HP:0001328)1.83794446
172Increased corneal curvature (HP:0100692)1.82350811
173Keratoconus (HP:0000563)1.82350811
174Tubulointerstitial abnormality (HP:0001969)1.82188227
175Upper limb muscle weakness (HP:0003484)1.81978012
176Petechiae (HP:0000967)1.81542724
177Tongue fasciculations (HP:0001308)1.81519238
178Breast hypoplasia (HP:0003187)1.80498657
179Premature ovarian failure (HP:0008209)1.80388833
180Fused cervical vertebrae (HP:0002949)1.80214984
181Panhypogammaglobulinemia (HP:0003139)1.80136757
182Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79347878
183Decreased central vision (HP:0007663)1.79088224
184Abnormality of small intestinal villus morphology (HP:0011472)1.78573661
185Oligodactyly (HP:0012165)1.76872075
186Atonic seizures (HP:0010819)1.76043336
187Abnormal respiratory motile cilium physiology (HP:0012261)1.75635320
188Multicystic kidney dysplasia (HP:0000003)1.74378591
189Focal motor seizures (HP:0011153)1.73452128
190Hyperglycinemia (HP:0002154)1.73320327
191Tubulointerstitial nephritis (HP:0001970)1.72482771
192Aplasia/Hypoplasia of the patella (HP:0006498)1.71900842
193Bony spicule pigmentary retinopathy (HP:0007737)1.71516747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.15392613
2FRK4.68305788
3GRK53.77656814
4ADRBK23.56318063
5GRK63.26348679
6IRAK33.18455142
7GRK13.01095975
8TTK2.98369713
9MAP4K22.93067918
10BMPR1B2.84763544
11ZAK2.73820775
12BUB12.69151573
13WNK32.61452975
14PINK12.53548368
15GRK72.49021216
16MAP3K42.41995540
17STK162.32864258
18NUAK12.26180735
19CSF1R2.24049483
20PLK42.21027059
21MAPK132.04940110
22WNK42.04617852
23IRAK42.03636033
24TRIM281.92023861
25SRPK11.81931671
26EIF2AK21.73768715
27MAP2K71.72379150
28WEE11.72355004
29STK101.71641217
30INSRR1.71495065
31EPHA21.68918715
32BCR1.67263369
33CDK71.66419592
34TAOK31.62828345
35STK391.62450439
36MAPK71.61706338
37TIE11.60145598
38TGFBR21.58140446
39PAK31.55406379
40MATK1.45488790
41PLK11.45131686
42ERN11.44042950
43OBSCN1.39459568
44MKNK21.38376432
45BLK1.37409494
46MARK11.35864496
47CHEK21.34361816
48CSNK1G31.26516586
49AKT31.25762665
50CSNK1G21.24877427
51TXK1.24739649
52BRSK21.24380434
53VRK11.21550014
54CSNK1G11.19467359
55OXSR11.15322742
56BCKDK1.15072666
57CDC71.11636773
58CSNK1A1L1.10353611
59NTRK21.09781108
60ERBB31.09112835
61NME21.07888734
62MOS1.06393421
63YES11.06213646
64EIF2AK11.03779472
65PLK21.03044527
66EIF2AK30.99112645
67MKNK10.98964921
68MAPKAPK50.96436514
69TGFBR10.95351054
70CASK0.94196822
71MAP4K10.91505296
72PRKCE0.91263689
73IKBKB0.89736154
74ATR0.88624709
75PRKG20.87347133
76DYRK30.86484884
77TLK10.86327440
78ACVR1B0.83461062
79ADRBK10.81291208
80PRKCG0.78981377
81CAMK40.78141959
82JAK30.77804657
83AURKB0.75535188
84NTRK30.74437493
85PHKG20.72168721
86PHKG10.72168721
87MAP2K60.71095359
88WNK10.70850145
89EPHA40.69593648
90PRKCI0.69457513
91CHEK10.69100115
92IRAK20.68687446
93CAMKK20.68314343
94BRD40.68021553
95NEK20.67921656
96TNK20.67068749
97DAPK20.65110712
98PTK2B0.64990457
99TEC0.64846876
100KIT0.64786938
101MINK10.64613929
102PIM20.64330036
103AURKA0.63736331
104HIPK20.63543616
105IRAK10.63242862
106RPS6KA50.63172269
107MAP3K70.60912920
108MUSK0.59553564
109MARK20.58759099
110CCNB10.58133488
111PNCK0.58024035
112PKN10.56027239
113ATM0.54665834
114PAK40.54301473
115CAMK2A0.53335888
116CDK80.53276413
117NLK0.52595320
118DYRK20.52444791
119RPS6KB20.51814540
120PIK3CG0.51386585
121NME10.50339583
122BTK0.50300500
123CSK0.48202414
124RPS6KA40.47811387
125KSR10.47558767
126ZAP700.47434401
127TSSK60.46235586
128SGK20.46128510
129SIK20.45850327
130FGFR20.45277893
131PRKAA10.45191341
132PRKACA0.45069297
133LYN0.44426044
134PRKCQ0.43546551
135AKT20.43327448
136MAPK40.41612718
137PIK3CA0.41312450
138TYRO30.41171165
139CDK20.41084525
140PLK30.41009464
141CSNK1A10.40014091
142CAMK10.39058707
143SYK0.38925179
144DYRK1A0.38291506
145TNIK0.37678419
146PRKCD0.37349491
147PRKG10.37014654
148MAPKAPK30.36257563
149STK40.35758021
150PASK0.35383633
151MARK30.35231421
152CDK40.34688149
153SGK2230.34616072
154SGK4940.34616072
155MAP3K80.34453333
156PRKAA20.34024156
157STK38L0.33375158
158FLT30.32525148
159MAP2K40.32240295
160CSNK1D0.32125741
161STK240.32038174
162STK30.31881861
163STK110.31824028
164CSNK2A10.30956556
165PIM10.30878470
166TAOK20.29540146
167LCK0.28401542
168CDK10.26941444
169CHUK0.26458289

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94882670
2Vitamin B6 metabolism_Homo sapiens_hsa007503.84050306
3DNA replication_Homo sapiens_hsa030303.39791046
4RNA polymerase_Homo sapiens_hsa030203.16134875
5Ribosome_Homo sapiens_hsa030103.14162403
6Mismatch repair_Homo sapiens_hsa034303.01311957
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.98326711
8Fanconi anemia pathway_Homo sapiens_hsa034602.88661187
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86485011
10Phototransduction_Homo sapiens_hsa047442.84695744
11Homologous recombination_Homo sapiens_hsa034402.82001594
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.56508468
13Butanoate metabolism_Homo sapiens_hsa006502.52614087
14Base excision repair_Homo sapiens_hsa034102.32854765
15Spliceosome_Homo sapiens_hsa030402.19855279
16Pyrimidine metabolism_Homo sapiens_hsa002402.15510740
17Nicotine addiction_Homo sapiens_hsa050332.06112449
18RNA transport_Homo sapiens_hsa030132.05793249
19Propanoate metabolism_Homo sapiens_hsa006402.02667248
20Proteasome_Homo sapiens_hsa030501.99254748
21Basal transcription factors_Homo sapiens_hsa030221.99049892
22Nucleotide excision repair_Homo sapiens_hsa034201.94929637
23Non-homologous end-joining_Homo sapiens_hsa034501.94434919
24Arachidonic acid metabolism_Homo sapiens_hsa005901.94381086
25RNA degradation_Homo sapiens_hsa030181.92066705
26One carbon pool by folate_Homo sapiens_hsa006701.84075481
27Nitrogen metabolism_Homo sapiens_hsa009101.78018788
28Selenocompound metabolism_Homo sapiens_hsa004501.73570973
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67849009
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61868773
31Cell cycle_Homo sapiens_hsa041101.60929678
32Primary immunodeficiency_Homo sapiens_hsa053401.60812765
33Olfactory transduction_Homo sapiens_hsa047401.58041783
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57259394
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.57168335
36Tryptophan metabolism_Homo sapiens_hsa003801.53984219
37Caffeine metabolism_Homo sapiens_hsa002321.49860722
38Fructose and mannose metabolism_Homo sapiens_hsa000511.48785258
39Linoleic acid metabolism_Homo sapiens_hsa005911.40663122
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38501376
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37356445
42Peroxisome_Homo sapiens_hsa041461.29664247
43p53 signaling pathway_Homo sapiens_hsa041151.27523053
44Purine metabolism_Homo sapiens_hsa002301.26082462
45Cardiac muscle contraction_Homo sapiens_hsa042601.24504436
46mRNA surveillance pathway_Homo sapiens_hsa030151.23705460
47Steroid biosynthesis_Homo sapiens_hsa001001.22532612
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20653452
49Herpes simplex infection_Homo sapiens_hsa051681.17390414
50Other glycan degradation_Homo sapiens_hsa005111.15085007
51Morphine addiction_Homo sapiens_hsa050321.14888612
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13269370
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.10634184
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.09314734
55Galactose metabolism_Homo sapiens_hsa000521.09171172
56GABAergic synapse_Homo sapiens_hsa047271.09106294
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06442930
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04375506
59ABC transporters_Homo sapiens_hsa020100.96083398
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.96076261
61Circadian entrainment_Homo sapiens_hsa047130.94391749
62Collecting duct acid secretion_Homo sapiens_hsa049660.94374733
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93031770
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92665167
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88840184
66Serotonergic synapse_Homo sapiens_hsa047260.88391386
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87439621
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87177088
69Circadian rhythm_Homo sapiens_hsa047100.87139341
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.86508392
71Folate biosynthesis_Homo sapiens_hsa007900.86337157
72Regulation of autophagy_Homo sapiens_hsa041400.85466100
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84540297
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80063284
75Hematopoietic cell lineage_Homo sapiens_hsa046400.78811962
76Graft-versus-host disease_Homo sapiens_hsa053320.78656507
77beta-Alanine metabolism_Homo sapiens_hsa004100.78410622
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77938445
79Insulin secretion_Homo sapiens_hsa049110.77350446
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76039077
81Dopaminergic synapse_Homo sapiens_hsa047280.75539108
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72466461
83Measles_Homo sapiens_hsa051620.71303871
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.68098750
85Huntingtons disease_Homo sapiens_hsa050160.64966491
86Sulfur relay system_Homo sapiens_hsa041220.64776932
87Epstein-Barr virus infection_Homo sapiens_hsa051690.64689096
88Pentose phosphate pathway_Homo sapiens_hsa000300.62883423
89Glutamatergic synapse_Homo sapiens_hsa047240.60810827
90Sulfur metabolism_Homo sapiens_hsa009200.59627666
91Cocaine addiction_Homo sapiens_hsa050300.58569438
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58457254
93Hedgehog signaling pathway_Homo sapiens_hsa043400.58362730
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56922222
95Ether lipid metabolism_Homo sapiens_hsa005650.56775253
96Protein export_Homo sapiens_hsa030600.56660976
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.55757562
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55226302
99Antigen processing and presentation_Homo sapiens_hsa046120.54601469
100Fatty acid elongation_Homo sapiens_hsa000620.54592536
101Ovarian steroidogenesis_Homo sapiens_hsa049130.54540565
102Oxidative phosphorylation_Homo sapiens_hsa001900.54340322
103Calcium signaling pathway_Homo sapiens_hsa040200.53181020
104Thyroid cancer_Homo sapiens_hsa052160.52668800
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49739235
106Leishmaniasis_Homo sapiens_hsa051400.49451197
107Metabolic pathways_Homo sapiens_hsa011000.48262156
108Glycerolipid metabolism_Homo sapiens_hsa005610.48002746
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.46980876
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46144000
111Parkinsons disease_Homo sapiens_hsa050120.45404052
112Cholinergic synapse_Homo sapiens_hsa047250.45115685
113Allograft rejection_Homo sapiens_hsa053300.45000031
114Influenza A_Homo sapiens_hsa051640.43891597
115Salivary secretion_Homo sapiens_hsa049700.43117037
116Amphetamine addiction_Homo sapiens_hsa050310.42970646
117Fatty acid degradation_Homo sapiens_hsa000710.42804499
118Fatty acid metabolism_Homo sapiens_hsa012120.42481785
119Long-term depression_Homo sapiens_hsa047300.42205717
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41104810
121Pyruvate metabolism_Homo sapiens_hsa006200.40038702
122Arginine and proline metabolism_Homo sapiens_hsa003300.39726684
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.38899976
124Autoimmune thyroid disease_Homo sapiens_hsa053200.38393238
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.38299963
126HTLV-I infection_Homo sapiens_hsa051660.37899675
127Dorso-ventral axis formation_Homo sapiens_hsa043200.37547966
128Apoptosis_Homo sapiens_hsa042100.36861567
129Retinol metabolism_Homo sapiens_hsa008300.36534001
130Oxytocin signaling pathway_Homo sapiens_hsa049210.35959414
131Inositol phosphate metabolism_Homo sapiens_hsa005620.35503017
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35274529
133Oocyte meiosis_Homo sapiens_hsa041140.34634550
134Sphingolipid metabolism_Homo sapiens_hsa006000.34281496
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34181734
136Acute myeloid leukemia_Homo sapiens_hsa052210.33578120
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31438420
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30910908
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30483826
140Vitamin digestion and absorption_Homo sapiens_hsa049770.30080814
141Chemical carcinogenesis_Homo sapiens_hsa052040.29250876
142Pathways in cancer_Homo sapiens_hsa052000.28828811
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28179707
144Notch signaling pathway_Homo sapiens_hsa043300.27838433
145Alzheimers disease_Homo sapiens_hsa050100.24856690
146Taste transduction_Homo sapiens_hsa047420.23612449
147African trypanosomiasis_Homo sapiens_hsa051430.23462715
148Basal cell carcinoma_Homo sapiens_hsa052170.22050087
149T cell receptor signaling pathway_Homo sapiens_hsa046600.21985489
150Viral carcinogenesis_Homo sapiens_hsa052030.21799788
151Glutathione metabolism_Homo sapiens_hsa004800.21712833
152* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21580916
153Systemic lupus erythematosus_Homo sapiens_hsa053220.20839304
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20765777
155Asthma_Homo sapiens_hsa053100.18098073
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.16628342

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