DEXI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.67677176
2muscle filament sliding (GO:0030049)5.67677176
3modulation by virus of host process (GO:0019054)4.90731959
4sarcoplasmic reticulum calcium ion transport (GO:0070296)4.81698930
5modulation by symbiont of host cellular process (GO:0044068)4.57098510
6actin-mediated cell contraction (GO:0070252)4.45696981
7skeletal muscle contraction (GO:0003009)4.35481117
8creatine metabolic process (GO:0006600)4.15950292
9kynurenine metabolic process (GO:0070189)4.01517581
10NADH metabolic process (GO:0006734)3.92919983
11cardiac muscle contraction (GO:0060048)3.91936703
12response to muscle activity (GO:0014850)3.91777862
13striated muscle contraction (GO:0006941)3.88843765
14myofibril assembly (GO:0030239)3.84176958
15tryptophan catabolic process (GO:0006569)3.78997086
16indole-containing compound catabolic process (GO:0042436)3.78997086
17indolalkylamine catabolic process (GO:0046218)3.78997086
18L-phenylalanine catabolic process (GO:0006559)3.75086187
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75086187
20dicarboxylic acid biosynthetic process (GO:0043650)3.74515803
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73820012
22L-phenylalanine metabolic process (GO:0006558)3.73820012
23aromatic amino acid family catabolic process (GO:0009074)3.71256380
24regulation of skeletal muscle contraction (GO:0014819)3.65475887
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.63516392
26sarcomere organization (GO:0045214)3.56891156
27response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.48646329
28actin filament-based movement (GO:0030048)3.43891712
29tryptophan metabolic process (GO:0006568)3.40772980
30cardiac myofibril assembly (GO:0055003)3.35130295
31bile acid biosynthetic process (GO:0006699)3.30131836
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.23347578
33modulation by virus of host morphology or physiology (GO:0019048)3.22210613
34skeletal muscle fiber development (GO:0048741)3.19955289
35glutamate metabolic process (GO:0006536)3.16316683
362-oxoglutarate metabolic process (GO:0006103)3.13977683
37coenzyme catabolic process (GO:0009109)3.12242658
38muscle contraction (GO:0006936)3.09163561
39negative regulation of potassium ion transmembrane transport (GO:1901380)3.06424113
40negative regulation of erythrocyte differentiation (GO:0045647)3.05902307
41lysine catabolic process (GO:0006554)3.05099571
42lysine metabolic process (GO:0006553)3.05099571
43ribosomal small subunit biogenesis (GO:0042274)3.04185355
44negative regulation of necroptotic process (GO:0060546)3.02074862
45regulation of glucocorticoid secretion (GO:2000849)3.01371982
46cellular modified amino acid catabolic process (GO:0042219)2.99644120
47negative regulation of necrotic cell death (GO:0060547)2.99163347
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96734442
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95369834
50cellular ketone body metabolic process (GO:0046950)2.94361811
51regulation of early endosome to late endosome transport (GO:2000641)2.93243071
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92850154
53regulation of relaxation of muscle (GO:1901077)2.91533003
54high-density lipoprotein particle remodeling (GO:0034375)2.88315824
55antigen processing and presentation of endogenous antigen (GO:0019883)2.85832601
56glyoxylate metabolic process (GO:0046487)2.84729925
57oxaloacetate metabolic process (GO:0006107)2.82851529
58regulation of corticosteroid hormone secretion (GO:2000846)2.81921097
59short-chain fatty acid metabolic process (GO:0046459)2.81318510
60urea metabolic process (GO:0019627)2.81115050
61urea cycle (GO:0000050)2.81115050
62cardiac muscle hypertrophy (GO:0003300)2.79362243
63alpha-linolenic acid metabolic process (GO:0036109)2.79228523
64sulfur amino acid catabolic process (GO:0000098)2.78980869
65poly(A)+ mRNA export from nucleus (GO:0016973)2.78414025
66positive regulation of receptor recycling (GO:0001921)2.78131573
67positive regulation of myotube differentiation (GO:0010831)2.77892569
68cysteine metabolic process (GO:0006534)2.76944130
69complement activation, alternative pathway (GO:0006957)2.76297411
70succinate metabolic process (GO:0006105)2.75460408
71muscle system process (GO:0003012)2.74627086
72barbed-end actin filament capping (GO:0051016)2.74305018
73focal adhesion assembly (GO:0048041)2.73021861
74cell-substrate adherens junction assembly (GO:0007045)2.73021861
75dicarboxylic acid catabolic process (GO:0043649)2.68608593
76alpha-amino acid catabolic process (GO:1901606)2.68245587
77synaptic vesicle docking involved in exocytosis (GO:0016081)2.68054516
78striated muscle hypertrophy (GO:0014897)2.66534533
79regulation of triglyceride catabolic process (GO:0010896)2.65074940
80aspartate family amino acid catabolic process (GO:0009068)2.63842424
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62398325
82glycogen catabolic process (GO:0005980)2.62216177
83phospholipid efflux (GO:0033700)2.62086845
84regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62028283
85neuronal action potential propagation (GO:0019227)2.61913722
86cellular potassium ion homeostasis (GO:0030007)2.61014261
87myotube cell development (GO:0014904)2.60727442
88regulation of cholesterol esterification (GO:0010872)2.59968652
89endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.59522113
90positive regulation of lipid storage (GO:0010884)2.59175822
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58654400
92signal complex assembly (GO:0007172)2.57957226
93skin morphogenesis (GO:0043589)2.56507614
94muscle hypertrophy (GO:0014896)2.56093115
95positive regulation of synapse maturation (GO:0090129)2.55683916
96gluconeogenesis (GO:0006094)2.55644283
97phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54678211
98nitrogen cycle metabolic process (GO:0071941)2.54030601
99cellular amino acid catabolic process (GO:0009063)2.53323995
100protein targeting to plasma membrane (GO:0072661)2.53038016
101valine metabolic process (GO:0006573)2.52792137
102indolalkylamine metabolic process (GO:0006586)2.52642475
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.52138669
104negative regulation of sterol transport (GO:0032372)2.51909445
105negative regulation of cholesterol transport (GO:0032375)2.51909445
106sterol catabolic process (GO:0016127)2.51892298
107cholesterol catabolic process (GO:0006707)2.51892298
108actomyosin structure organization (GO:0031032)2.51632728
109locomotory exploration behavior (GO:0035641)2.51180560
110peptidyl-glutamic acid carboxylation (GO:0017187)2.51030054
111protein carboxylation (GO:0018214)2.51030054
112negative regulation of lipid transport (GO:0032369)2.50809651
113regulation of protein activation cascade (GO:2000257)2.50175350
114positive regulation of protein sumoylation (GO:0033235)2.49604798
115negative regulation of cell size (GO:0045792)2.48886555
116negative regulation of fibrinolysis (GO:0051918)2.48778958
117cellular biogenic amine catabolic process (GO:0042402)2.48049739
118amine catabolic process (GO:0009310)2.48049739
119bile acid metabolic process (GO:0008206)2.47962288
120adherens junction assembly (GO:0034333)2.47615740
121respiratory system process (GO:0003016)2.47265745
122response to mercury ion (GO:0046689)2.47056263
123cellular response to thyroid hormone stimulus (GO:0097067)2.45586577
124aromatic amino acid family metabolic process (GO:0009072)2.45561318
125ketone body metabolic process (GO:1902224)2.43158434
126glucan catabolic process (GO:0009251)2.42785877
127sodium ion export (GO:0071436)2.42190072
128reverse cholesterol transport (GO:0043691)2.41775772
129regulation of fibrinolysis (GO:0051917)2.41683713
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.41488662
131response to inactivity (GO:0014854)2.41299535
132synaptic vesicle maturation (GO:0016188)2.40851432
133serine family amino acid catabolic process (GO:0009071)2.40552780
134regulation of cholesterol efflux (GO:0010874)2.40200146
135cell volume homeostasis (GO:0006884)2.39640661
136viral transcription (GO:0019083)2.39564991
137cardiac muscle hypertrophy in response to stress (GO:0014898)2.38904886
138muscle hypertrophy in response to stress (GO:0003299)2.38904886
139cardiac muscle adaptation (GO:0014887)2.38904886
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38662383
141regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.38322066
142acetyl-CoA metabolic process (GO:0006084)2.37869949
143benzene-containing compound metabolic process (GO:0042537)2.37773926
144regulation of synapse structural plasticity (GO:0051823)2.36976432
145calcium-mediated signaling using intracellular calcium source (GO:0035584)2.36645092
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35572476
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35572476
148positive regulation of lipid catabolic process (GO:0050996)2.34185729
149cofactor catabolic process (GO:0051187)2.33595112
150NAD biosynthetic process (GO:0009435)2.33564051
151regulation of translational fidelity (GO:0006450)2.33396655
152amino-acid betaine metabolic process (GO:0006577)2.32990728
153regulation of complement activation (GO:0030449)2.31826728
154muscle cell cellular homeostasis (GO:0046716)2.31542474
155indole-containing compound metabolic process (GO:0042430)2.31503847
156glucan biosynthetic process (GO:0009250)2.31332994
157glycogen biosynthetic process (GO:0005978)2.31332994
158plasma membrane repair (GO:0001778)2.31283650
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31088573
160regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.30869258
161hexose biosynthetic process (GO:0019319)2.30489283
162fructose metabolic process (GO:0006000)2.30143945
163cerebellar granule cell differentiation (GO:0021707)2.30035728
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.28917273
165neuromuscular process controlling balance (GO:0050885)2.28403586
166protein-lipid complex remodeling (GO:0034368)2.28235874
167macromolecular complex remodeling (GO:0034367)2.28235874
168plasma lipoprotein particle remodeling (GO:0034369)2.28235874
169monosaccharide biosynthetic process (GO:0046364)2.28227354
170UV protection (GO:0009650)2.28111658
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.28075115
172negative regulation of lipase activity (GO:0060192)2.27478160
173neurotransmitter secretion (GO:0007269)2.27396145
174regulation of triglyceride biosynthetic process (GO:0010866)2.27292395
175ethanol oxidation (GO:0006069)2.27185613
176protein localization to endosome (GO:0036010)2.26512254
177monocarboxylic acid catabolic process (GO:0072329)2.26300220
178regulation of necrotic cell death (GO:0010939)2.25945845
179muscle cell fate commitment (GO:0042693)2.25797604
180glutamate secretion (GO:0014047)2.25380098
181cell communication by electrical coupling (GO:0010644)2.24815872
182homocysteine metabolic process (GO:0050667)2.23377442
183carboxylic acid catabolic process (GO:0046395)2.22503606
184organic acid catabolic process (GO:0016054)2.22503606
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.21430540
186disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.21001957
187killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.21001957
188regulation of fatty acid beta-oxidation (GO:0031998)2.18181441
189regulation of cell communication by electrical coupling (GO:0010649)2.16851306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06439899
2EZH2_22144423_ChIP-Seq_EOC_Human4.01610973
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.35728779
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91414208
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.89299613
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82046414
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.69114195
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55360477
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.53354793
10VDR_21846776_ChIP-Seq_THP-1_Human2.35659449
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.29388091
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.23843359
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21833050
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12629180
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.10932030
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02374605
17TET1_21451524_ChIP-Seq_MESCs_Mouse2.01146821
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.96112112
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92942515
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91111826
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88047716
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86334294
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86021175
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85675356
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85421558
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84557391
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82580864
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82580864
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81116918
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80246638
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79508328
32P68_20966046_ChIP-Seq_HELA_Human1.76598236
33GATA1_22025678_ChIP-Seq_K562_Human1.73830545
34MYC_22102868_ChIP-Seq_BL_Human1.69561860
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69211878
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68413448
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67482979
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67346455
39DROSHA_22980978_ChIP-Seq_HELA_Human1.66453673
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66362919
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64529225
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64372683
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.60915137
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.59217497
45LXR_22292898_ChIP-Seq_THP-1_Human1.55438578
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55199102
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55006677
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.53362531
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44322687
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.44000906
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42746421
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41265570
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39467758
54MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.39162812
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.38983430
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38160411
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.37764295
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.33484406
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.32494145
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.31495432
61ZNF263_19887448_ChIP-Seq_K562_Human1.30218103
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29470686
63VDR_24763502_ChIP-Seq_THP-1_Human1.28825201
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27816699
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.27311475
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26310280
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24877476
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23934619
69REST_21632747_ChIP-Seq_MESCs_Mouse1.22368463
70CTCF_21964334_Chip-Seq_Bcells_Human1.19870578
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.19115269
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18826334
73CLOCK_20551151_ChIP-Seq_293T_Human1.18742185
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.17956414
75MAF_26560356_Chip-Seq_TH2_Human1.17191075
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.16674613
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16382268
78TP53_22127205_ChIP-Seq_IMR90_Human1.16122771
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16053280
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14317427
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14119971
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.13959835
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11974202
84KDM2B_26808549_Chip-Seq_K562_Human1.11945314
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11009693
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10135162
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07915230
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07912992
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07251972
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07173974
91* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06974848
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06612189
93EGR1_19032775_ChIP-ChIP_M12_Human1.06521413
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05943780
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05891150
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04762809
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04705090
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04368026
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04343259
100CTCF_27219007_Chip-Seq_Bcells_Human1.02421446
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02233960
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01506081
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00539411
104RUNX_20019798_ChIP-Seq_JUKART_Human1.00448804
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00211564
106SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99974240
107* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99235954
108TP63_22573176_ChIP-Seq_HFKS_Human0.99136985
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98079919
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97258293
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96999129
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.96073704
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.92450255
114KDM2B_26808549_Chip-Seq_DND41_Human0.91736612
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91141790
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89627693
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89620309
118BCL6_27268052_Chip-Seq_Bcells_Human0.87299042
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86899482
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86440329
121SA1_27219007_Chip-Seq_Bcells_Human0.85508244
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.85236297
123TCF7_22412390_ChIP-Seq_EML_Mouse0.85092496
124AR_21572438_ChIP-Seq_LNCaP_Human0.84329297
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.82949137
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.82577348
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.82577348
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82483378
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81580133
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.79875048
131* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78482152
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77806874
133BCOR_27268052_Chip-Seq_Bcells_Human0.77111908
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.76425959
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75784516
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74947257
137MAF_26560356_Chip-Seq_TH1_Human0.74489983
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74306344
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73811716
140FOXA2_19822575_ChIP-Seq_HepG2_Human0.73586211
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.73244819
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72927748
143SMC4_20622854_ChIP-Seq_HELA_Human0.72640660
144TAF2_19829295_ChIP-Seq_ESCs_Human0.71702029
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69085202
146RACK7_27058665_Chip-Seq_MCF-7_Human0.69020734
147CREB1_26743006_Chip-Seq_LNCaP_Human0.69000137
148SPI1_20517297_ChIP-Seq_HL60_Human0.68748859
149BCAT_22108803_ChIP-Seq_LS180_Human0.68633136
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68115745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.88352922
2MP0005085_abnormal_gallbladder_physiolo3.56904488
3MP0005360_urolithiasis3.50537316
4MP0004859_abnormal_synaptic_plasticity3.33767607
5MP0005365_abnormal_bile_salt3.08643257
6MP0005083_abnormal_biliary_tract2.94031736
7MP0005058_abnormal_lysosome_morphology2.74469530
8MP0003252_abnormal_bile_duct2.71010916
9MP0004510_myositis2.61901852
10MP0000750_abnormal_muscle_regeneration2.57501078
11MP0002837_dystrophic_cardiac_calcinosis2.57158336
12MP0008875_abnormal_xenobiotic_pharmacok2.54413259
13MP0004233_abnormal_muscle_weight2.52641614
14MP0000759_abnormal_skeletal_muscle2.49208336
15MP0001835_abnormal_antigen_presentation2.35209571
16MP0003879_abnormal_hair_cell2.27389794
17MP0003279_aneurysm2.15503321
18MP0003880_abnormal_central_pattern2.14700980
19MP0000751_myopathy2.10721572
20MP0001666_abnormal_nutrient_absorption2.07950663
21MP0002254_reproductive_system_inflammat1.99691229
22MP0005409_darkened_coat_color1.98732216
23MP0003646_muscle_fatigue1.96831125
24MP0000685_abnormal_immune_system1.91090512
25MP0003635_abnormal_synaptic_transmissio1.88338187
26MP0005369_muscle_phenotype1.87007318
27MP0002822_catalepsy1.83753663
28MP0000343_altered_response_to1.81656368
29MP0002269_muscular_atrophy1.80123568
30MP0010329_abnormal_lipoprotein_level1.78818112
31MP0002332_abnormal_exercise_endurance1.75718686
32MP0008438_abnormal_cutaneous_collagen1.71998261
33MP0009745_abnormal_behavioral_response1.67771539
34MP0002064_seizures1.63665580
35MP0000733_abnormal_muscle_development1.61978452
36MP0004084_abnormal_cardiac_muscle1.58240672
37MP0000003_abnormal_adipose_tissue1.56386059
38MP0005387_immune_system_phenotype1.52515869
39MP0001790_abnormal_immune_system1.52515869
40MP0005332_abnormal_amino_acid1.47534022
41MP0005423_abnormal_somatic_nervous1.46773806
42MP0002138_abnormal_hepatobiliary_system1.44974584
43MP0002909_abnormal_adrenal_gland1.44889443
44MP0004130_abnormal_muscle_cell1.44080991
45MP0002108_abnormal_muscle_morphology1.42766277
46MP0003075_altered_response_to1.41922621
47MP0003191_abnormal_cellular_cholesterol1.41286487
48MP0005584_abnormal_enzyme/coenzyme_acti1.40970565
49MP0009764_decreased_sensitivity_to1.39844934
50MP0001348_abnormal_lacrimal_gland1.39570927
51MP0001968_abnormal_touch/_nociception1.38032238
52MP0000013_abnormal_adipose_tissue1.37778988
53MP0002089_abnormal_postnatal_growth/wei1.36675129
54MP0003329_amyloid_beta_deposits1.35270970
55MP0009379_abnormal_foot_pigmentation1.34420372
56MP0009840_abnormal_foam_cell1.32334565
57MP0002063_abnormal_learning/memory/cond1.31421593
58MP0000749_muscle_degeneration1.30835240
59MP0008569_lethality_at_weaning1.29646659
60MP0004484_altered_response_of1.28262635
61MP0005330_cardiomyopathy1.27891110
62MP0002876_abnormal_thyroid_physiology1.26896183
63MP0002118_abnormal_lipid_homeostasis1.26205004
64MP0009046_muscle_twitch1.25279564
65MP0003137_abnormal_impulse_conducting1.22780750
66MP0004145_abnormal_muscle_electrophysio1.22743111
67MP0010630_abnormal_cardiac_muscle1.22507775
68MP0006138_congestive_heart_failure1.21306335
69MP0005375_adipose_tissue_phenotype1.19103702
70MP0003195_calcinosis1.18380830
71MP0004858_abnormal_nervous_system1.17328024
72MP0008874_decreased_physiological_sensi1.17308145
73MP0005319_abnormal_enzyme/_coenzyme1.13152892
74MP0001984_abnormal_olfaction1.12849901
75MP0005166_decreased_susceptibility_to1.11924215
76MP0000604_amyloidosis1.11863971
77MP0002736_abnormal_nociception_after1.11704500
78MP0006036_abnormal_mitochondrial_physio1.08510830
79MP0005535_abnormal_body_temperature1.07495043
80MP0002148_abnormal_hypersensitivity_rea1.07279926
81MP0009780_abnormal_chondrocyte_physiolo1.05468178
82MP0005257_abnormal_intraocular_pressure1.04934986
83MP0009785_altered_susceptibility_to1.03933551
84MP0003828_pulmonary_edema1.03580002
85MP0000609_abnormal_liver_physiology1.03412374
86MP0002272_abnormal_nervous_system1.03341509
87MP0004270_analgesia1.02206201
88MP0003806_abnormal_nucleotide_metabolis1.01584394
89MP0004087_abnormal_muscle_fiber1.01402000
90MP0001958_emphysema1.01214218
91MP0003172_abnormal_lysosome_physiology1.00957146
92MP0001501_abnormal_sleep_pattern1.00249996
93MP0005084_abnormal_gallbladder_morpholo0.99953586
94MP0001849_ear_inflammation0.99426528
95MP0003436_decreased_susceptibility_to0.98873728
96MP0008260_abnormal_autophagy0.98472346
97MP0001853_heart_inflammation0.98211840
98MP0005025_abnormal_response_to0.97087436
99MP0002735_abnormal_chemical_nociception0.97009473
100MP0010234_abnormal_vibrissa_follicle0.96317892
101MP0000920_abnormal_myelination0.96255309
102MP0005623_abnormal_meninges_morphology0.95608003
103MP0008961_abnormal_basal_metabolism0.95445993
104MP0004036_abnormal_muscle_relaxation0.95404657
105MP0004215_abnormal_myocardial_fiber0.94328970
106MP0005385_cardiovascular_system_phenoty0.93360171
107MP0001544_abnormal_cardiovascular_syste0.93360171
108MP0000747_muscle_weakness0.92950316
109MP0004185_abnormal_adipocyte_glucose0.92671305
110MP0003868_abnormal_feces_composition0.91650318
111MP0002572_abnormal_emotion/affect_behav0.91286228
112MP0004142_abnormal_muscle_tone0.89883355
113MP0008469_abnormal_protein_level0.89575049
114MP0001800_abnormal_humoral_immune0.89070332
115MP0001440_abnormal_grooming_behavior0.88964069
116MP0002733_abnormal_thermal_nociception0.86579380
117MP0003633_abnormal_nervous_system0.85226906
118MP0005671_abnormal_response_to0.84383755
119MP0005165_increased_susceptibility_to0.84161389
120MP0005000_abnormal_immune_tolerance0.83854533
121MP0001502_abnormal_circadian_rhythm0.83768027
122MP0005666_abnormal_adipose_tissue0.81731807
123MP0002971_abnormal_brown_adipose0.81648447
124MP0003638_abnormal_response/metabolism_0.81442883
125MP0001970_abnormal_pain_threshold0.81294448
126MP0002877_abnormal_melanocyte_morpholog0.81003788
127MP0009333_abnormal_splenocyte_physiolog0.80844596
128MP0005620_abnormal_muscle_contractility0.80736012
129MP0002078_abnormal_glucose_homeostasis0.80124995
130MP0005448_abnormal_energy_balance0.79023749
131MP0003303_peritoneal_inflammation0.78479140
132MP0003634_abnormal_glial_cell0.78460310
133MP0002998_abnormal_bone_remodeling0.77356239
134MP0005451_abnormal_body_composition0.77216781
135MP0002106_abnormal_muscle_physiology0.76609359
136MP0002249_abnormal_larynx_morphology0.76087764
137MP0003300_gastrointestinal_ulcer0.75955415
138MP0006035_abnormal_mitochondrial_morpho0.75792297
139MP0002067_abnormal_sensory_capabilities0.74877958
140MP0002972_abnormal_cardiac_muscle0.74542559
141MP0001873_stomach_inflammation0.73590259
142MP0003705_abnormal_hypodermis_morpholog0.73573528
143MP0005503_abnormal_tendon_morphology0.73402880
144MP0002166_altered_tumor_susceptibility0.73296846
145MP0005670_abnormal_white_adipose0.69099599
146MP0009384_cardiac_valve_regurgitation0.68933851
147MP0008004_abnormal_stomach_pH0.68601185
148MP0001905_abnormal_dopamine_level0.67599745
149MP0002127_abnormal_cardiovascular_syste0.67471672
150MP0003690_abnormal_glial_cell0.67350482
151MP0000678_abnormal_parathyroid_gland0.66049492
152MP0003566_abnormal_cell_adhesion0.61678352
153MP0003123_paternal_imprinting0.59315568
154MP0000681_abnormal_thyroid_gland0.57841460
155MP0005595_abnormal_vascular_smooth0.56635741
156MP0001727_abnormal_embryo_implantation0.56015783
157MP0001661_extended_life_span0.55539434
158MP0001915_intracranial_hemorrhage0.54256266
159MP0002295_abnormal_pulmonary_circulatio0.49082317

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.43661688
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.29162265
3Nemaline bodies (HP:0003798)6.13735705
4Type 1 muscle fiber predominance (HP:0003803)5.85312375
5Centrally nucleated skeletal muscle fibers (HP:0003687)4.52114022
6Neck muscle weakness (HP:0000467)4.13753604
7Myopathic facies (HP:0002058)4.02791136
8Distal lower limb muscle weakness (HP:0009053)3.95321324
9Deep venous thrombosis (HP:0002625)3.93549883
10Muscle fiber splitting (HP:0003555)3.90323758
11Abnormality of skeletal muscle fiber size (HP:0012084)3.88451379
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.82123798
13Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.65407159
14Exercise-induced myalgia (HP:0003738)3.64755359
15Increased variability in muscle fiber diameter (HP:0003557)3.58252115
16Increased connective tissue (HP:0009025)3.51214818
17Axonal loss (HP:0003447)3.48134303
18Rhabdomyolysis (HP:0003201)3.46239231
19Myokymia (HP:0002411)3.38480879
20Ketosis (HP:0001946)3.36366248
21Distal arthrogryposis (HP:0005684)3.34560157
22Round ear (HP:0100830)3.33148947
23Prolonged partial thromboplastin time (HP:0003645)3.21700758
24Xanthomatosis (HP:0000991)3.18345550
25Focal motor seizures (HP:0011153)3.17942794
26Sudden death (HP:0001699)3.15179296
27Hyperammonemia (HP:0001987)3.11378506
28Ventricular fibrillation (HP:0001663)3.05447698
29Intrahepatic cholestasis (HP:0001406)2.98013287
30Ketoacidosis (HP:0001993)2.96155361
31Ulnar deviation of the wrist (HP:0003049)2.95076804
32Neurofibrillary tangles (HP:0002185)2.94920308
33Spinal rigidity (HP:0003306)2.92403920
34Calf muscle hypertrophy (HP:0008981)2.91518038
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91271426
36Distal lower limb amyotrophy (HP:0008944)2.87047748
37Muscle hypertrophy of the lower extremities (HP:0008968)2.84988688
38Myoglobinuria (HP:0002913)2.83160028
39Complement deficiency (HP:0004431)2.81988880
40Hypobetalipoproteinemia (HP:0003563)2.79051445
41Hyperglycinemia (HP:0002154)2.78330092
42Hyperlipoproteinemia (HP:0010980)2.77873777
43Bulbar palsy (HP:0001283)2.74180904
44Mildly elevated creatine phosphokinase (HP:0008180)2.65113183
45Foot dorsiflexor weakness (HP:0009027)2.57781341
46Difficulty running (HP:0009046)2.57539744
47Protrusio acetabuli (HP:0003179)2.56798772
48Abnormality of the Achilles tendon (HP:0005109)2.55467459
49Progressive external ophthalmoplegia (HP:0000590)2.52393257
50Cerebral inclusion bodies (HP:0100314)2.50747272
51Hyperglycinuria (HP:0003108)2.49055308
52Status epilepticus (HP:0002133)2.48318257
53Scapular winging (HP:0003691)2.47121786
54Abnormality of the foot musculature (HP:0001436)2.44596255
55Visual hallucinations (HP:0002367)2.44329210
56Myotonia (HP:0002486)2.43274705
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41164747
58Calcaneovalgus deformity (HP:0001848)2.34633635
59Cerebral edema (HP:0002181)2.34181856
60Abnormality of complement system (HP:0005339)2.32777416
61Abnormality of glycine metabolism (HP:0010895)2.32413792
62Abnormality of serine family amino acid metabolism (HP:0010894)2.32413792
63Exercise-induced muscle cramps (HP:0003710)2.31431425
64Rimmed vacuoles (HP:0003805)2.31079738
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29621027
66Heart block (HP:0012722)2.27137760
67Recurrent gram-negative bacterial infections (HP:0005420)2.26140688
68Hyperventilation (HP:0002883)2.25821071
69Achilles tendon contracture (HP:0001771)2.25276677
70Bundle branch block (HP:0011710)2.25030286
71Upper motor neuron abnormality (HP:0002127)2.24357232
72Cholelithiasis (HP:0001081)2.23260960
73Ventricular tachycardia (HP:0004756)2.22421451
74Gout (HP:0001997)2.21448682
75Joint hemorrhage (HP:0005261)2.20549385
76Increased IgM level (HP:0003496)2.20375770
77Neonatal onset (HP:0003623)2.20193600
78Focal seizures (HP:0007359)2.20180818
79Slender build (HP:0001533)2.19609868
80Difficulty climbing stairs (HP:0003551)2.16089633
81Abnormality of fatty-acid metabolism (HP:0004359)2.16070816
82Muscle stiffness (HP:0003552)2.15368845
83Abnormality of the left ventricular outflow tract (HP:0011103)2.14719005
84Subaortic stenosis (HP:0001682)2.14719005
85Atrioventricular block (HP:0001678)2.12146723
86Agnosia (HP:0010524)2.10688973
87Hypoglycemic seizures (HP:0002173)2.10242390
88Abnormal atrioventricular conduction (HP:0005150)2.09920911
89Colitis (HP:0002583)2.09881734
90Febrile seizures (HP:0002373)2.09544422
91Hyporeflexia of lower limbs (HP:0002600)2.08822806
92Abnormality of the common coagulation pathway (HP:0010990)2.07496270
93Acute encephalopathy (HP:0006846)2.06159960
94Lower limb amyotrophy (HP:0007210)2.05740211
95Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04723175
96Dicarboxylic aciduria (HP:0003215)2.04723175
97Spontaneous abortion (HP:0005268)2.04519191
98Hypolipoproteinemia (HP:0010981)2.03617066
99Fat malabsorption (HP:0002630)2.02981438
100EMG: neuropathic changes (HP:0003445)2.02553331
101Deformed tarsal bones (HP:0008119)2.00996773
102Amyloidosis (HP:0011034)2.00972454
103Metabolic acidosis (HP:0001942)2.00418933
104Generalized muscle weakness (HP:0003324)1.99244374
105Abnormal gallbladder morphology (HP:0012437)1.97441811
106Myocardial infarction (HP:0001658)1.95702296
107Disinhibition (HP:0000734)1.94247608
108Panhypogammaglobulinemia (HP:0003139)1.94143851
109Abnormality of the calf musculature (HP:0001430)1.92343442
110Ventricular arrhythmia (HP:0004308)1.91056761
111Asymmetric septal hypertrophy (HP:0001670)1.89523162
112Lipoatrophy (HP:0100578)1.89331578
113Dilated cardiomyopathy (HP:0001644)1.88721611
114Hypoglycemic coma (HP:0001325)1.87964212
115Ragged-red muscle fibers (HP:0003200)1.87511360
116Hypoalphalipoproteinemia (HP:0003233)1.86995982
117Abnormal mitochondria in muscle tissue (HP:0008316)1.86974945
118Abnormal delayed hypersensitivity skin test (HP:0002963)1.86692867
119Absent phalangeal crease (HP:0006109)1.86555807
120Vertebral compression fractures (HP:0002953)1.84670460
121Absence seizures (HP:0002121)1.84568462
122Syncope (HP:0001279)1.84398954
123Generalized amyotrophy (HP:0003700)1.83245912
124Hepatic necrosis (HP:0002605)1.83033334
125Conjunctival hamartoma (HP:0100780)1.82750123
126Systemic lupus erythematosus (HP:0002725)1.82227480
127Malignant hyperthermia (HP:0002047)1.82022010
128Frequent falls (HP:0002359)1.81979010
129Depression (HP:0000716)1.81599031
130Anxiety (HP:0000739)1.80915157
131Focal dystonia (HP:0004373)1.79961054
132Abnormality of the intrinsic pathway (HP:0010989)1.79549151
133Rapidly progressive (HP:0003678)1.79028409
134Waddling gait (HP:0002515)1.78955280
135Obstructive sleep apnea (HP:0002870)1.78796081
136Personality changes (HP:0000751)1.78695637
137Mask-like facies (HP:0000298)1.78311002
138Increased muscle lipid content (HP:0009058)1.78044297
139Acute necrotizing encephalopathy (HP:0006965)1.75392671
140Hepatocellular necrosis (HP:0001404)1.75078088
141Chronic otitis media (HP:0000389)1.74454917
142Delayed CNS myelination (HP:0002188)1.74357029
143EMG: myopathic abnormalities (HP:0003458)1.74237530
144Hypercortisolism (HP:0001578)1.73881819
145Torticollis (HP:0000473)1.73442225
146Cerebral aneurysm (HP:0004944)1.73244761
147Lethargy (HP:0001254)1.73226562
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72853061
149Areflexia of lower limbs (HP:0002522)1.72675340
150Tinnitus (HP:0000360)1.71759332
151Mitral stenosis (HP:0001718)1.71415003
152Gastrointestinal infarctions (HP:0005244)1.70588645
153Progressive muscle weakness (HP:0003323)1.70566988
154Steatorrhea (HP:0002570)1.69970230
155Abnormality of purine metabolism (HP:0004352)1.69568169
156Epidermoid cyst (HP:0200040)1.68909805
157Craniofacial dystonia (HP:0012179)1.68873227
158Supranuclear gaze palsy (HP:0000605)1.68671172
159Recurrent cutaneous fungal infections (HP:0011370)1.68515471
160Ulnar bowing (HP:0003031)1.67761627
161Premature rupture of membranes (HP:0001788)1.66197603
162Thoracic kyphosis (HP:0002942)1.65098455
163Abnormality of the calcaneus (HP:0008364)1.64303928
164Gowers sign (HP:0003391)1.61944796
165Limb-girdle muscle atrophy (HP:0003797)1.61751360
166Weak cry (HP:0001612)1.59327548
167Reticulocytosis (HP:0001923)1.57301941
168Oligomenorrhea (HP:0000876)1.54912680
169Abnormality of glycosphingolipid metabolism (HP:0004343)1.54011222
170Abnormality of glycolipid metabolism (HP:0010969)1.54011222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.10425554
2BCKDK2.71165968
3RIPK42.65785082
4NTRK32.52513287
5EEF2K2.27918678
6DAPK22.10045713
7MAP3K122.00134550
8ERN11.98534364
9MAP4K11.97211542
10EPHA41.90189050
11PKN21.87006680
12MAP2K41.84026948
13NME21.73125698
14MAP3K71.66700804
15PHKG11.66245323
16PHKG21.66245323
17FGFR41.58569447
18ICK1.56473256
19CAMKK11.56445986
20KSR21.50591731
21TBK11.47350520
22MAP3K41.44282884
23MAP3K131.42556059
24RIPK11.41695815
25SIK21.40103468
26LMTK21.39281437
27MAP3K141.37121383
28MAPKAPK31.33977431
29PINK11.31390682
30MAP3K111.30412929
31MAP3K91.30394230
32MINK11.28505620
33SIK11.27466756
34TNK21.24532110
35TTN1.23010699
36DMPK1.22419127
37PRKCH1.20004683
38SYK1.19737174
39MARK21.15878160
40LRRK21.14976409
41ARAF1.14040162
42PRKD21.13147081
43ABL21.13105547
44JAK11.12493131
45GRK51.09050137
46OBSCN1.08444936
47MAP3K31.07196513
48MOS1.06500392
49SIK31.06114949
50STK381.03500842
51TESK11.02802668
52IRAK31.02743411
53LATS21.01431432
54TAOK20.99492147
55MAP2K70.98440756
56FLT30.95210947
57MAP3K10.94498366
58TYK20.93889961
59BMPR20.92441086
60RAF10.92007104
61GRK60.91776097
62ILK0.90714977
63KIT0.85476360
64PRKCQ0.84058962
65MAP3K20.84014267
66SMG10.83710819
67PIM20.83494306
68DAPK30.83320813
69JAK30.83247261
70CDK190.82798953
71DAPK10.82449862
72RET0.82433726
73FES0.82349194
74RPS6KA20.82108882
75IKBKE0.82091285
76JAK20.81692944
77SGK30.80120101
78MAPK120.79655578
79MUSK0.79491997
80PIK3CG0.77687945
81PDK10.77472361
82TAOK10.74520752
83IKBKB0.74517220
84PAK60.72234059
85SGK20.71755691
86TLK10.70338622
87LIMK10.69719734
88PRKD30.68567676
89CAMK10.68353256
90BRAF0.66793136
91MYLK0.66552735
92PDPK10.65914384
93MAP2K60.64726587
94MAPK110.63843555
95MARK10.63481339
96NTRK20.63225802
97PRPF4B0.60889599
98NTRK10.60624633
99KSR10.60217149
100CAMKK20.60046890
101CDK50.59312540
102DDR20.58348882
103BMX0.58101420
104TGFBR20.57678862
105SCYL20.56754280
106MTOR0.56588294
107MAP3K80.55471711
108PDGFRA0.55410688
109EPHB10.55247605
110NME10.55139296
111MAP2K10.54871751
112CDC42BPA0.54338645
113BTK0.54278907
114MAP2K30.54049489
115CSF1R0.53744878
116CAMK2G0.52914307
117RPS6KC10.52385863
118RPS6KL10.52385863
119TESK20.51852266
120MAPK40.51272929
121TAOK30.50637595
122MAP3K100.50368403
123CAMK40.49992195
124PRKCG0.49736926
125AKT20.49697509
126KDR0.49476624
127PTK60.48228048
128SGK2230.47714225
129SGK4940.47714225
130DYRK1B0.47523667
131GRK70.47470618
132CDK11A0.45864517
133PRKD10.45570565
134HCK0.44808860
135RPS6KB20.44554643
136CAMK2B0.44425368
137IRAK10.44326499
138TIE10.43162284
139TRPM70.42518279
140CDK150.42065126
141PRKAA10.41763148
142PRKG20.40983502
143NEK90.40608054
144MAPK70.39406352
145PAK20.37451105
146CDK140.36534511
147ROCK10.36335237
148UHMK10.36007375

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.45531885
2Nitrogen metabolism_Homo sapiens_hsa009103.55318448
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.27458548
4Arginine biosynthesis_Homo sapiens_hsa002202.59181546
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.02682877
6Fatty acid degradation_Homo sapiens_hsa000711.87257423
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83135484
8Other glycan degradation_Homo sapiens_hsa005111.81826862
9Tryptophan metabolism_Homo sapiens_hsa003801.73734729
10Pentose phosphate pathway_Homo sapiens_hsa000301.64924856
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62075589
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61737051
13Propanoate metabolism_Homo sapiens_hsa006401.55155410
14Butanoate metabolism_Homo sapiens_hsa006501.50110506
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47561188
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42273989
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42020665
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42015373
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41769298
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39861053
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39341393
22Fatty acid metabolism_Homo sapiens_hsa012121.35718153
23PPAR signaling pathway_Homo sapiens_hsa033201.32140132
24Complement and coagulation cascades_Homo sapiens_hsa046101.31259974
25Bile secretion_Homo sapiens_hsa049761.30417643
26Olfactory transduction_Homo sapiens_hsa047401.30381624
27Cardiac muscle contraction_Homo sapiens_hsa042601.23603958
28Peroxisome_Homo sapiens_hsa041461.17758324
29beta-Alanine metabolism_Homo sapiens_hsa004101.15311984
30Phenylalanine metabolism_Homo sapiens_hsa003601.13592715
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11528749
32Arginine and proline metabolism_Homo sapiens_hsa003301.11287313
33Nicotine addiction_Homo sapiens_hsa050331.10759414
34Synaptic vesicle cycle_Homo sapiens_hsa047211.09030850
35GABAergic synapse_Homo sapiens_hsa047271.08040088
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08016404
37Fructose and mannose metabolism_Homo sapiens_hsa000511.07129301
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.06192792
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06170824
40Oxidative phosphorylation_Homo sapiens_hsa001901.04409042
41Parkinsons disease_Homo sapiens_hsa050121.02922199
42AMPK signaling pathway_Homo sapiens_hsa041521.01731897
43Staphylococcus aureus infection_Homo sapiens_hsa051501.01461146
44Circadian entrainment_Homo sapiens_hsa047131.01305336
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97120460
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96334433
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94356069
48Alzheimers disease_Homo sapiens_hsa050100.92474624
49Focal adhesion_Homo sapiens_hsa045100.92333588
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89708409
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89033187
52Primary immunodeficiency_Homo sapiens_hsa053400.88577393
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88132749
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87641533
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.86658710
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86488980
57Glutamatergic synapse_Homo sapiens_hsa047240.86268975
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85908757
59Galactose metabolism_Homo sapiens_hsa000520.85827012
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.83706057
61Morphine addiction_Homo sapiens_hsa050320.83187099
62Long-term potentiation_Homo sapiens_hsa047200.82847360
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81715615
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81615037
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81490473
66Pyruvate metabolism_Homo sapiens_hsa006200.81083826
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.81044833
68Starch and sucrose metabolism_Homo sapiens_hsa005000.81034205
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80831164
70Gastric acid secretion_Homo sapiens_hsa049710.80274101
71Melanogenesis_Homo sapiens_hsa049160.80241255
72Chemical carcinogenesis_Homo sapiens_hsa052040.79543767
73Salivary secretion_Homo sapiens_hsa049700.79078956
74Glioma_Homo sapiens_hsa052140.78750971
75Ribosome_Homo sapiens_hsa030100.77748765
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.76981380
77Calcium signaling pathway_Homo sapiens_hsa040200.75773289
78Carbon metabolism_Homo sapiens_hsa012000.75093701
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.74235032
80Acute myeloid leukemia_Homo sapiens_hsa052210.73208812
81B cell receptor signaling pathway_Homo sapiens_hsa046620.72740190
82Oxytocin signaling pathway_Homo sapiens_hsa049210.72086472
83Bladder cancer_Homo sapiens_hsa052190.71826839
84Notch signaling pathway_Homo sapiens_hsa043300.71133013
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.70785812
86Pancreatic secretion_Homo sapiens_hsa049720.69421571
87Cholinergic synapse_Homo sapiens_hsa047250.68973241
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.68841373
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68740437
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68551112
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68038680
92Insulin secretion_Homo sapiens_hsa049110.66570446
93ABC transporters_Homo sapiens_hsa020100.66245263
94Linoleic acid metabolism_Homo sapiens_hsa005910.66211801
95Lysosome_Homo sapiens_hsa041420.65631674
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65575257
97Amoebiasis_Homo sapiens_hsa051460.64952644
98Endocytosis_Homo sapiens_hsa041440.64243041
99Gap junction_Homo sapiens_hsa045400.63985167
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63279803
101ErbB signaling pathway_Homo sapiens_hsa040120.62768128
102Amphetamine addiction_Homo sapiens_hsa050310.62371933
103Non-small cell lung cancer_Homo sapiens_hsa052230.61644741
104Tyrosine metabolism_Homo sapiens_hsa003500.61514928
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61494486
106Circadian rhythm_Homo sapiens_hsa047100.61135841
107Viral myocarditis_Homo sapiens_hsa054160.60990806
108Histidine metabolism_Homo sapiens_hsa003400.59172456
109MAPK signaling pathway_Homo sapiens_hsa040100.58824394
110GnRH signaling pathway_Homo sapiens_hsa049120.58718122
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57927138
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57541151
113Fatty acid elongation_Homo sapiens_hsa000620.56800044
114Fat digestion and absorption_Homo sapiens_hsa049750.56546538
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55583680
116mTOR signaling pathway_Homo sapiens_hsa041500.54508769
117Insulin resistance_Homo sapiens_hsa049310.54201382
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52550286
119Estrogen signaling pathway_Homo sapiens_hsa049150.52544761
120Dilated cardiomyopathy_Homo sapiens_hsa054140.52265908
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51526142
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.51444611
123Chronic myeloid leukemia_Homo sapiens_hsa052200.51436689
124Glucagon signaling pathway_Homo sapiens_hsa049220.51379350
125Biosynthesis of amino acids_Homo sapiens_hsa012300.51049983
126Renin secretion_Homo sapiens_hsa049240.50592129
127Dopaminergic synapse_Homo sapiens_hsa047280.50463088
128Taste transduction_Homo sapiens_hsa047420.50162848
129Allograft rejection_Homo sapiens_hsa053300.48305774
130Pertussis_Homo sapiens_hsa051330.48217041
131Prion diseases_Homo sapiens_hsa050200.47190084
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.45615442
133Fatty acid biosynthesis_Homo sapiens_hsa000610.45561145
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44609751
135Sulfur relay system_Homo sapiens_hsa041220.44354418
136ECM-receptor interaction_Homo sapiens_hsa045120.43841690
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43512913
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.43482652
139Leishmaniasis_Homo sapiens_hsa051400.42827203
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42209477
141cAMP signaling pathway_Homo sapiens_hsa040240.41721473
142Vibrio cholerae infection_Homo sapiens_hsa051100.41688098
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41424539
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41284022
145Osteoclast differentiation_Homo sapiens_hsa043800.41195606
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41017108
147Caffeine metabolism_Homo sapiens_hsa002320.40478209
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.40162075
149Retinol metabolism_Homo sapiens_hsa008300.38676154
150VEGF signaling pathway_Homo sapiens_hsa043700.37007005
151African trypanosomiasis_Homo sapiens_hsa051430.36928306
152Type II diabetes mellitus_Homo sapiens_hsa049300.36353205
153Insulin signaling pathway_Homo sapiens_hsa049100.36327612
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36134404
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35267126

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