DFFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.04024610
2DNA deamination (GO:0045006)5.84014614
3ribosomal small subunit assembly (GO:0000028)5.34644978
4fucose catabolic process (GO:0019317)4.48472014
5L-fucose metabolic process (GO:0042354)4.48472014
6L-fucose catabolic process (GO:0042355)4.48472014
7formation of translation preinitiation complex (GO:0001731)4.47205127
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46961646
9DNA strand elongation (GO:0022616)4.41688886
10maturation of SSU-rRNA (GO:0030490)4.27362164
11DNA strand elongation involved in DNA replication (GO:0006271)4.24374649
12negative regulation of telomere maintenance (GO:0032205)4.16930188
13telomere maintenance via semi-conservative replication (GO:0032201)4.11883831
14viral transcription (GO:0019083)3.99780408
15translational termination (GO:0006415)3.96646034
16ribosomal small subunit biogenesis (GO:0042274)3.90022759
17nucleobase biosynthetic process (GO:0046112)3.80064834
18termination of RNA polymerase III transcription (GO:0006386)3.75085669
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.75085669
20telomere maintenance via telomere lengthening (GO:0010833)3.72475856
21DNA replication initiation (GO:0006270)3.72309087
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70896945
23proteasome assembly (GO:0043248)3.70877850
24translational elongation (GO:0006414)3.62617152
25ribosome biogenesis (GO:0042254)3.62385887
26protein localization to kinetochore (GO:0034501)3.61719947
27cotranslational protein targeting to membrane (GO:0006613)3.61437808
28ribonucleoprotein complex biogenesis (GO:0022613)3.61303337
29piRNA metabolic process (GO:0034587)3.61094830
30platelet dense granule organization (GO:0060155)3.58687204
31protein targeting to ER (GO:0045047)3.58676197
32purine nucleobase biosynthetic process (GO:0009113)3.58044445
33respiratory chain complex IV assembly (GO:0008535)3.56978179
34translational initiation (GO:0006413)3.54319899
35DNA unwinding involved in DNA replication (GO:0006268)3.53258250
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51579816
37ribosomal large subunit biogenesis (GO:0042273)3.48164841
38rRNA processing (GO:0006364)3.47572187
39telomere maintenance via recombination (GO:0000722)3.46838603
40protein localization to endoplasmic reticulum (GO:0070972)3.45420266
41ribosome assembly (GO:0042255)3.43098250
42water-soluble vitamin biosynthetic process (GO:0042364)3.42164167
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39619121
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37358283
45folic acid-containing compound biosynthetic process (GO:0009396)3.36599772
46positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.35348506
47rRNA metabolic process (GO:0016072)3.34022474
48spliceosomal snRNP assembly (GO:0000387)3.32444359
49pseudouridine synthesis (GO:0001522)3.28768454
50preassembly of GPI anchor in ER membrane (GO:0016254)3.27582484
51cytochrome complex assembly (GO:0017004)3.26616343
52protein complex biogenesis (GO:0070271)3.26554666
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25633638
54cellular ketone body metabolic process (GO:0046950)3.24365276
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23907650
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20817183
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.20817183
58NADH dehydrogenase complex assembly (GO:0010257)3.20817183
59telomere maintenance via telomerase (GO:0007004)3.20551600
60rRNA modification (GO:0000154)3.19143074
61rRNA catabolic process (GO:0016075)3.14611522
62cellular protein complex disassembly (GO:0043624)3.13871739
63IMP biosynthetic process (GO:0006188)3.13083841
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12734935
65protein localization to chromosome, centromeric region (GO:0071459)3.12383091
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.11262358
67mitotic recombination (GO:0006312)3.10141242
68seminiferous tubule development (GO:0072520)3.08836126
69maturation of 5.8S rRNA (GO:0000460)3.07155215
70attachment of spindle microtubules to kinetochore (GO:0008608)3.06773757
71translation (GO:0006412)3.06195119
72protein-cofactor linkage (GO:0018065)3.05818483
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05325270
74mitochondrial respiratory chain complex assembly (GO:0033108)3.04826608
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03740489
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03740489
77DNA replication checkpoint (GO:0000076)3.02439077
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00714025
79transcription-coupled nucleotide-excision repair (GO:0006283)3.00139314
80mannosylation (GO:0097502)2.99712841
81DNA methylation involved in gamete generation (GO:0043046)2.99694542
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98243796
83viral life cycle (GO:0019058)2.98060675
84IMP metabolic process (GO:0046040)2.96744370
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95801642
86ketone body metabolic process (GO:1902224)2.94677786
87indole-containing compound catabolic process (GO:0042436)2.93732067
88indolalkylamine catabolic process (GO:0046218)2.93732067
89tryptophan catabolic process (GO:0006569)2.93732067
90recombinational repair (GO:0000725)2.92189640
91positive regulation of cAMP-mediated signaling (GO:0043950)2.91279278
92S-adenosylmethionine metabolic process (GO:0046500)2.91193098
93viral mRNA export from host cell nucleus (GO:0046784)2.91069299
94negative regulation of mast cell activation (GO:0033004)2.90617907
95double-strand break repair via homologous recombination (GO:0000724)2.90299645
96L-methionine salvage (GO:0071267)2.90035083
97L-methionine biosynthetic process (GO:0071265)2.90035083
98amino acid salvage (GO:0043102)2.90035083
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89602087
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.89531115
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89359036
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88808976
103somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88679424
104isotype switching (GO:0045190)2.88679424
105somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88679424
106kynurenine metabolic process (GO:0070189)2.86613095
107ubiquinone biosynthetic process (GO:0006744)2.86190417
108protein import into peroxisome matrix (GO:0016558)2.84404870
109indolalkylamine metabolic process (GO:0006586)2.83098941
110synapsis (GO:0007129)2.82658985
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.82551766
112RNA-dependent DNA replication (GO:0006278)2.80745570
113positive regulation of gamma-delta T cell activation (GO:0046645)2.79924738
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79467967
115protein complex disassembly (GO:0043241)2.79284068
116reciprocal meiotic recombination (GO:0007131)2.78532669
117reciprocal DNA recombination (GO:0035825)2.78532669
118nuclear-transcribed mRNA catabolic process (GO:0000956)2.78240873
1197-methylguanosine mRNA capping (GO:0006370)2.77993982
120cytidine deamination (GO:0009972)2.77285340
121cytidine metabolic process (GO:0046087)2.77285340
122cytidine catabolic process (GO:0006216)2.77285340
123magnesium ion transport (GO:0015693)2.76998315
124epithelial cilium movement (GO:0003351)2.76706824
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76366765
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76366765
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76366765
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75782789
129negative regulation of ligase activity (GO:0051352)2.75782789
130cellular component biogenesis (GO:0044085)2.74896065
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74555849
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74555849
133termination of RNA polymerase I transcription (GO:0006363)2.74121058
134CENP-A containing nucleosome assembly (GO:0034080)2.74030517
135signal transduction involved in DNA damage checkpoint (GO:0072422)2.73817573
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73817573
137RNA capping (GO:0036260)2.72995050
1387-methylguanosine RNA capping (GO:0009452)2.72995050
139positive regulation of prostaglandin secretion (GO:0032308)2.71950388
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.71587758
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71529901
142mitotic metaphase plate congression (GO:0007080)2.71106067
143DNA damage response, detection of DNA damage (GO:0042769)2.70690527
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.68596396
145detection of light stimulus involved in visual perception (GO:0050908)2.68556641
146detection of light stimulus involved in sensory perception (GO:0050962)2.68556641
147positive regulation of fatty acid transport (GO:2000193)2.68389291
148telomere organization (GO:0032200)2.67987492
149telomere maintenance (GO:0000723)2.67873342
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67648269
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.67648269
152mRNA catabolic process (GO:0006402)2.67601160
153axoneme assembly (GO:0035082)2.66915084
154regulation of telomere maintenance (GO:0032204)2.66442469
155tRNA methylation (GO:0030488)2.66343535
156response to pheromone (GO:0019236)2.65862938
157tryptophan metabolic process (GO:0006568)2.65694471
158negative regulation of protein oligomerization (GO:0032460)2.65551035
159DNA-templated transcription, termination (GO:0006353)2.65451541
160regulation of glucokinase activity (GO:0033131)2.64766176
161regulation of hexokinase activity (GO:1903299)2.64766176
162ubiquinone metabolic process (GO:0006743)2.64576935
163adenosine metabolic process (GO:0046085)2.63246539
164glycerophospholipid catabolic process (GO:0046475)2.61855603
165peptidyl-histidine modification (GO:0018202)2.61825631
166protein polyglutamylation (GO:0018095)2.61615888
167nonmotile primary cilium assembly (GO:0035058)2.52727997
168positive regulation of defense response to virus by host (GO:0002230)2.52161687
169cornea development in camera-type eye (GO:0061303)2.51840892
170replication fork processing (GO:0031297)2.51373048
171male meiosis (GO:0007140)2.48764535
172ATP synthesis coupled proton transport (GO:0015986)2.46867684
173energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46867684
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.44766088
175regulation of inositol phosphate biosynthetic process (GO:0010919)2.43817523
176sulfation (GO:0051923)2.43262075
177DNA demethylation (GO:0080111)2.42962015
178synaptic transmission, cholinergic (GO:0007271)2.42194294
179regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41677900
180multicellular organism reproduction (GO:0032504)2.41344057
181photoreceptor cell maintenance (GO:0045494)2.41082412
182growth hormone receptor signaling pathway (GO:0060396)2.40743502
183GPI anchor metabolic process (GO:0006505)2.39785350
184tRNA processing (GO:0008033)2.39362950
185cilium organization (GO:0044782)2.38621501
186pyrimidine ribonucleoside catabolic process (GO:0046133)2.38156607
187base-excision repair, AP site formation (GO:0006285)2.37760161
188rhodopsin mediated signaling pathway (GO:0016056)2.37683612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.62755257
2ZNF274_21170338_ChIP-Seq_K562_Hela4.39221625
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.92502440
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88102210
5VDR_22108803_ChIP-Seq_LS180_Human3.46347230
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.22279026
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13617627
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.95696002
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90037641
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.86513756
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74752085
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74548127
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70578587
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66805046
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66430865
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61655651
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55437448
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.54988080
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52132154
20IGF1R_20145208_ChIP-Seq_DFB_Human2.47660831
21VDR_23849224_ChIP-Seq_CD4+_Human2.45910541
22MYC_22102868_ChIP-Seq_BL_Human2.30130991
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28834554
24* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27416094
25GBX2_23144817_ChIP-Seq_PC3_Human2.25955282
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.25277455
27EWS_26573619_Chip-Seq_HEK293_Human2.22952200
28FOXP3_21729870_ChIP-Seq_TREG_Human2.16255572
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14587097
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14574724
31XRN2_22483619_ChIP-Seq_HELA_Human2.10503101
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09875825
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08626288
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.07383268
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06358971
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04297545
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99025272
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98471343
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96556497
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95952528
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94886869
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.92994278
43GABP_19822575_ChIP-Seq_HepG2_Human1.92941157
44MYC_18940864_ChIP-ChIP_HL60_Human1.92705251
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91612884
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89608572
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84268451
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84065934
49FUS_26573619_Chip-Seq_HEK293_Human1.84038934
50TP53_22573176_ChIP-Seq_HFKS_Human1.83842015
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83621221
52DCP1A_22483619_ChIP-Seq_HELA_Human1.82664748
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79597390
54ER_23166858_ChIP-Seq_MCF-7_Human1.78977427
55CIITA_25753668_ChIP-Seq_RAJI_Human1.77968006
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76948395
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76729200
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76541406
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.74573632
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72631455
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.72272325
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70723246
63TTF2_22483619_ChIP-Seq_HELA_Human1.68133794
64IRF1_19129219_ChIP-ChIP_H3396_Human1.66467811
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66068899
66P300_19829295_ChIP-Seq_ESCs_Human1.65837905
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62817278
68SCL_19346495_ChIP-Seq_HPC-7_Human1.62351946
69SPI1_23547873_ChIP-Seq_NB4_Human1.62350958
70VDR_21846776_ChIP-Seq_THP-1_Human1.61485077
71* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60583410
72ELK1_19687146_ChIP-ChIP_HELA_Human1.60297426
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57155434
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.54553066
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.53289281
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52893742
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.52684783
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52476325
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51457868
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47570479
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46329204
82EZH2_22144423_ChIP-Seq_EOC_Human1.39347907
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38659970
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38534288
85NCOR_22424771_ChIP-Seq_293T_Human1.38023743
86AR_20517297_ChIP-Seq_VCAP_Human1.36546865
87TAF15_26573619_Chip-Seq_HEK293_Human1.36489648
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.36416470
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35885893
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.35772936
91HOXB7_26014856_ChIP-Seq_BT474_Human1.34745449
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.33687725
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33687725
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33132804
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31594385
96KDM5A_27292631_Chip-Seq_BREAST_Human1.31460567
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30760908
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30469956
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30181438
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29720786
101AR_21909140_ChIP-Seq_LNCAP_Human1.26647943
102BCAT_22108803_ChIP-Seq_LS180_Human1.25322681
103CBP_20019798_ChIP-Seq_JUKART_Human1.25104716
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25104716
105* GATA3_26560356_Chip-Seq_TH2_Human1.24917040
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.24766816
107MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24681297
108SOX2_19829295_ChIP-Seq_ESCs_Human1.24423003
109NANOG_19829295_ChIP-Seq_ESCs_Human1.24423003
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24328698
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24297107
112STAT3_23295773_ChIP-Seq_U87_Human1.23312136
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23218109
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22794657
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22794657
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22568424
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21568965
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21051878
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.19431129
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18661018
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18418282
122TCF4_23295773_ChIP-Seq_U87_Human1.18049071
123MYB_26560356_Chip-Seq_TH1_Human1.16093243
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15787959
125ELK1_22589737_ChIP-Seq_MCF10A_Human1.14814663
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14573959
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12951625
128REST_21632747_ChIP-Seq_MESCs_Mouse1.12502706
129* ERA_21632823_ChIP-Seq_H3396_Human1.12493288
130MYB_26560356_Chip-Seq_TH2_Human1.11877741
131AR_25329375_ChIP-Seq_VCAP_Human1.11876652
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11578900
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10944258
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10643831
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09065847
136GATA1_22025678_ChIP-Seq_K562_Human1.08636211
137MYC_19829295_ChIP-Seq_ESCs_Human1.08383901
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08307378
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.07551448
140* MAF_26560356_Chip-Seq_TH1_Human1.07484509
141NFE2_27457419_Chip-Seq_LIVER_Mouse1.07477067
142TAF2_19829295_ChIP-Seq_ESCs_Human1.06669864
143RNF2_27304074_Chip-Seq_NSC_Mouse1.05906262
144SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05475706
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05165825
146KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05150679
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04522469
148TCF4_22108803_ChIP-Seq_LS180_Human1.04473079
149RUNX1_22412390_ChIP-Seq_EML_Mouse1.04337480
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03909488
151TFEB_21752829_ChIP-Seq_HELA_Human1.03385096
152NANOG_20526341_ChIP-Seq_ESCs_Human1.03339626
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02377105
154BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01966127
155* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01028172
156* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00851646
157KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00632918
158GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99955481
159* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99917312
160CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99716504
161* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99069210
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98105015
163UTX_26944678_Chip-Seq_JUKART_Human0.97946897
164TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97861731
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97834666
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.97675235
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97603695
168* MAF_26560356_Chip-Seq_TH2_Human0.96208767
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95665362
170AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95579875
171SMAD4_21741376_ChIP-Seq_EPCs_Human0.95483364
172* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95132361
173SMAD4_21799915_ChIP-Seq_A2780_Human0.94091827
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.93517429
175FOXH1_21741376_ChIP-Seq_EPCs_Human0.93509051
176VDR_24763502_ChIP-Seq_THP-1_Human0.92299811
177CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91494873
178CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89919392
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89077219
180GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87963990
181PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87144249
182SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86992869
183STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86579650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.19743845
2MP0010094_abnormal_chromosome_stability3.84086679
3MP0003111_abnormal_nucleus_morphology3.75912484
4MP0000569_abnormal_digit_pigmentation3.62882034
5MP0002396_abnormal_hematopoietic_system3.55247354
6MP0008057_abnormal_DNA_replication3.35398773
7MP0004957_abnormal_blastocyst_morpholog3.22625625
8MP0003077_abnormal_cell_cycle3.08291198
9MP0008058_abnormal_DNA_repair2.93876637
10MP0001835_abnormal_antigen_presentation2.68566467
11MP0005084_abnormal_gallbladder_morpholo2.67619636
12MP0003656_abnormal_erythrocyte_physiolo2.62963882
13MP0003763_abnormal_thymus_physiology2.54250323
14MP0003195_calcinosis2.49170492
15MP0003123_paternal_imprinting2.42925127
16MP0000490_abnormal_crypts_of2.39697038
17MP0005671_abnormal_response_to2.34540724
18* MP0002398_abnormal_bone_marrow2.31549550
19MP0002138_abnormal_hepatobiliary_system2.28480952
20MP0002102_abnormal_ear_morphology2.26610280
21MP0004808_abnormal_hematopoietic_stem2.26047297
22MP0000372_irregular_coat_pigmentation2.20105159
23MP0009333_abnormal_splenocyte_physiolog2.18618110
24MP0005397_hematopoietic_system_phenotyp2.16220078
25MP0001545_abnormal_hematopoietic_system2.16220078
26MP0003787_abnormal_imprinting2.16064044
27MP0001800_abnormal_humoral_immune2.12682216
28MP0008007_abnormal_cellular_replicative2.11644062
29* MP0002722_abnormal_immune_system2.03917172
30MP0000689_abnormal_spleen_morphology2.03491274
31MP0000685_abnormal_immune_system2.03108956
32MP0003786_premature_aging1.98883068
33MP0005083_abnormal_biliary_tract1.98025964
34MP0005551_abnormal_eye_electrophysiolog1.97465082
35MP0002653_abnormal_ependyma_morphology1.93275264
36MP0006292_abnormal_olfactory_placode1.90348689
37MP0002452_abnormal_antigen_presenting1.90091280
38MP0002420_abnormal_adaptive_immunity1.88959683
39MP0005000_abnormal_immune_tolerance1.86257775
40* MP0000703_abnormal_thymus_morphology1.85564389
41MP0001819_abnormal_immune_cell1.85194109
42MP0001968_abnormal_touch/_nociception1.84841124
43* MP0000716_abnormal_immune_system1.84370519
44MP0006072_abnormal_retinal_apoptosis1.82265397
45MP0005645_abnormal_hypothalamus_physiol1.81121881
46MP0002837_dystrophic_cardiac_calcinosis1.80478143
47* MP0002429_abnormal_blood_cell1.78181829
48MP0002876_abnormal_thyroid_physiology1.77084227
49MP0003436_decreased_susceptibility_to1.76987017
50MP0000465_gastrointestinal_hemorrhage1.76892155
51MP0002723_abnormal_immune_serum1.76831689
52MP0009785_altered_susceptibility_to1.75507297
53MP0002095_abnormal_skin_pigmentation1.72139162
54MP0001919_abnormal_reproductive_system1.67997877
55MP0006054_spinal_hemorrhage1.65041217
56MP0003136_yellow_coat_color1.63892373
57MP0005025_abnormal_response_to1.62893616
58MP0008875_abnormal_xenobiotic_pharmacok1.61612177
59MP0005174_abnormal_tail_pigmentation1.61326682
60MP0008260_abnormal_autophagy1.58176215
61MP0005075_abnormal_melanosome_morpholog1.56472837
62MP0002019_abnormal_tumor_incidence1.56065267
63MP0002938_white_spotting1.55968435
64MP0005389_reproductive_system_phenotype1.55913532
65MP0008872_abnormal_physiological_respon1.52035674
66MP0003646_muscle_fatigue1.50642968
67MP0005387_immune_system_phenotype1.49603842
68MP0001790_abnormal_immune_system1.49603842
69MP0009046_muscle_twitch1.48906137
70MP0002166_altered_tumor_susceptibility1.44816252
71MP0002277_abnormal_respiratory_mucosa1.43668143
72MP0002148_abnormal_hypersensitivity_rea1.42697053
73MP0001730_embryonic_growth_arrest1.41172848
74MP0000350_abnormal_cell_proliferation1.40537829
75MP0005253_abnormal_eye_physiology1.39910799
76MP0002736_abnormal_nociception_after1.39843681
77MP0009745_abnormal_behavioral_response1.38016263
78MP0004142_abnormal_muscle_tone1.37854850
79MP0004885_abnormal_endolymph1.37003307
80MP0002638_abnormal_pupillary_reflex1.36301657
81MP0004147_increased_porphyrin_level1.35125334
82MP0005646_abnormal_pituitary_gland1.35049040
83MP0001485_abnormal_pinna_reflex1.34963598
84MP0002405_respiratory_system_inflammati1.34798978
85* MP0000313_abnormal_cell_death1.33589223
86MP0005464_abnormal_platelet_physiology1.33426847
87MP0002419_abnormal_innate_immunity1.30479657
88MP0002693_abnormal_pancreas_physiology1.30178520
89MP0002928_abnormal_bile_duct1.29752671
90MP0008932_abnormal_embryonic_tissue1.28811032
91MP0005365_abnormal_bile_salt1.23863658
92MP0004133_heterotaxia1.23619735
93MP0002163_abnormal_gland_morphology1.23229821
94MP0004742_abnormal_vestibular_system1.20529510
95MP0005187_abnormal_penis_morphology1.20244274
96MP0000427_abnormal_hair_cycle1.18526629
97MP0009379_abnormal_foot_pigmentation1.18187593
98MP0003186_abnormal_redox_activity1.17035760
99MP0003724_increased_susceptibility_to1.16586188
100MP0010155_abnormal_intestine_physiology1.15927225
101MP0004043_abnormal_pH_regulation1.14549170
102MP0002132_abnormal_respiratory_system1.13713108
103MP0000631_abnormal_neuroendocrine_gland1.13053033
104MP0001853_heart_inflammation1.12841987
105MP0003315_abnormal_perineum_morphology1.08833502
106MP0002272_abnormal_nervous_system1.08730063
107MP0001845_abnormal_inflammatory_respons1.08244858
108MP0002006_tumorigenesis1.08234256
109MP0006036_abnormal_mitochondrial_physio1.08208741
110MP0005085_abnormal_gallbladder_physiolo1.06702901
111MP0002160_abnormal_reproductive_system1.06149429
112MP0008877_abnormal_DNA_methylation1.05344332
113MP0002933_joint_inflammation1.05307631
114MP0010307_abnormal_tumor_latency1.05231811
115MP0003866_abnormal_defecation1.03907890
116MP0002080_prenatal_lethality1.03480890
117MP0001764_abnormal_homeostasis1.01434577
118MP0000015_abnormal_ear_pigmentation1.00302783
119MP0001501_abnormal_sleep_pattern0.99596306
120MP0001697_abnormal_embryo_size0.99323100
121MP0003011_delayed_dark_adaptation0.99258520
122MP0000858_altered_metastatic_potential0.97984780
123MP0006082_CNS_inflammation0.92692296
124MP0001529_abnormal_vocalization0.92559608
125MP0001486_abnormal_startle_reflex0.91072143
126MP0004924_abnormal_behavior0.89755433
127MP0005386_behavior/neurological_phenoty0.89755433
128MP0002557_abnormal_social/conspecific_i0.89319973
129MP0001984_abnormal_olfaction0.87698849
130MP0003806_abnormal_nucleotide_metabolis0.87680673
131MP0002064_seizures0.87259368
132MP0000358_abnormal_cell_content/0.87207190
133MP0005332_abnormal_amino_acid0.87042043
134MP0006035_abnormal_mitochondrial_morpho0.85404732
135MP0006276_abnormal_autonomic_nervous0.83430483
136MP0005310_abnormal_salivary_gland0.83276195
137MP0009278_abnormal_bone_marrow0.82918433
138MP0003283_abnormal_digestive_organ0.82884166
139MP0002234_abnormal_pharynx_morphology0.78406549
140MP0009764_decreased_sensitivity_to0.78267203
141MP0005379_endocrine/exocrine_gland_phen0.78007791
142MP0002733_abnormal_thermal_nociception0.77584729
143MP0001672_abnormal_embryogenesis/_devel0.77477828
144MP0005380_embryogenesis_phenotype0.77477828
145MP0003890_abnormal_embryonic-extraembry0.77151425
146MP0001970_abnormal_pain_threshold0.74993024
147MP0003984_embryonic_growth_retardation0.74624091
148MP0008995_early_reproductive_senescence0.74058409
149MP0001944_abnormal_pancreas_morphology0.74037658
150MP0008469_abnormal_protein_level0.73420516
151MP0000477_abnormal_intestine_morphology0.72863522
152MP0002088_abnormal_embryonic_growth/wei0.70958675
153MP0003698_abnormal_male_reproductive0.70604989
154MP0002572_abnormal_emotion/affect_behav0.70393143
155MP0002210_abnormal_sex_determination0.70069832
156MP0005384_cellular_phenotype0.70068852
157MP0003567_abnormal_fetal_cardiomyocyte0.69566834
158MP0002086_abnormal_extraembryonic_tissu0.69362319
159MP0005220_abnormal_exocrine_pancreas0.69287652
160MP0001905_abnormal_dopamine_level0.68913360
161MP0003718_maternal_effect0.68833357
162MP0001145_abnormal_male_reproductive0.68364260
163MP0001873_stomach_inflammation0.68016453
164MP0005647_abnormal_sex_gland0.67499842
165MP0001324_abnormal_eye_pigmentation0.66881553
166MP0005621_abnormal_cell_physiology0.66797902
167MP0003137_abnormal_impulse_conducting0.66523538
168MP0005195_abnormal_posterior_eye0.66457898
169MP0003121_genomic_imprinting0.66301332
170MP0001502_abnormal_circadian_rhythm0.65922934
171MP0005377_hearing/vestibular/ear_phenot0.65770306
172MP0003878_abnormal_ear_physiology0.65770306
173MP0000383_abnormal_hair_follicle0.65764045
174MP0001929_abnormal_gametogenesis0.65672844
175MP0001986_abnormal_taste_sensitivity0.65622964
176MP0003221_abnormal_cardiomyocyte_apopto0.63521770
177MP0004947_skin_inflammation0.62851466
178MP0000653_abnormal_sex_gland0.62606506
179MP0008873_increased_physiological_sensi0.62238005
180MP0002089_abnormal_postnatal_growth/wei0.59675066

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.78947023
2Aplastic anemia (HP:0001915)4.31913442
3Abnormal number of erythroid precursors (HP:0012131)4.20061969
4Pancreatic cysts (HP:0001737)4.12709138
5Abnormality of cells of the erythroid lineage (HP:0012130)4.04983609
6Abnormality of midbrain morphology (HP:0002418)3.97104066
7Molar tooth sign on MRI (HP:0002419)3.97104066
8Rough bone trabeculation (HP:0100670)3.84173536
9Pancreatic fibrosis (HP:0100732)3.83825775
10Congenital stationary night blindness (HP:0007642)3.81066858
11Reticulocytopenia (HP:0001896)3.73447490
12Type II lissencephaly (HP:0007260)3.50111959
13IgM deficiency (HP:0002850)3.49661954
14True hermaphroditism (HP:0010459)3.48930063
15Cellulitis (HP:0100658)3.47551832
16Nephronophthisis (HP:0000090)3.45414200
17Thrombocytosis (HP:0001894)3.40300335
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.37857948
19Cerebral hypomyelination (HP:0006808)3.34178506
20Agammaglobulinemia (HP:0004432)3.17522373
21Abnormality of the renal medulla (HP:0100957)3.10295702
22Panhypogammaglobulinemia (HP:0003139)3.09450969
23Oral leukoplakia (HP:0002745)3.03840686
24Petechiae (HP:0000967)3.02079563
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.01409964
26Breast hypoplasia (HP:0003187)2.99586049
27Chronic hepatic failure (HP:0100626)2.97299305
28Macrocytic anemia (HP:0001972)2.94026315
29Recurrent viral infections (HP:0004429)2.90031371
30Premature graying of hair (HP:0002216)2.88158486
31Lymphoma (HP:0002665)2.83717817
32Abolished electroretinogram (ERG) (HP:0000550)2.80780482
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79744592
34Abnormality of alanine metabolism (HP:0010916)2.79744592
35Hyperalaninemia (HP:0003348)2.79744592
36Abnormality of T cell physiology (HP:0011840)2.78523924
37Abnormality of the renal cortex (HP:0011035)2.77927393
38Medial flaring of the eyebrow (HP:0010747)2.77914334
39Pendular nystagmus (HP:0012043)2.74595695
40Fair hair (HP:0002286)2.71547880
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.70062753
42Abnormal trabecular bone morphology (HP:0100671)2.70045517
43Abnormality of T cells (HP:0002843)2.64671156
44Cellular immunodeficiency (HP:0005374)2.64603526
45Hyperventilation (HP:0002883)2.64592505
46Type I transferrin isoform profile (HP:0003642)2.63496689
47Microcytic anemia (HP:0001935)2.63199211
48Bone marrow hypocellularity (HP:0005528)2.62387887
49Abnormal rod and cone electroretinograms (HP:0008323)2.62155759
50Meningitis (HP:0001287)2.61396566
51Carpal bone hypoplasia (HP:0001498)2.60711994
52Microretrognathia (HP:0000308)2.59743804
53Irregular epiphyses (HP:0010582)2.59674246
54Myelodysplasia (HP:0002863)2.56753939
55Pancytopenia (HP:0001876)2.55541718
56Abnormal drinking behavior (HP:0030082)2.55380408
57Polydipsia (HP:0001959)2.55380408
58Recurrent fungal infections (HP:0002841)2.55337311
59Attenuation of retinal blood vessels (HP:0007843)2.55062339
60Agnosia (HP:0010524)2.54417750
61Abnormality of the anterior horn cell (HP:0006802)2.51966062
62Degeneration of anterior horn cells (HP:0002398)2.51966062
63IgG deficiency (HP:0004315)2.51609114
64Bile duct proliferation (HP:0001408)2.50367702
65Abnormal biliary tract physiology (HP:0012439)2.50367702
66Stomatitis (HP:0010280)2.48058251
6711 pairs of ribs (HP:0000878)2.47510322
68Congenital, generalized hypertrichosis (HP:0004540)2.43013086
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42766924
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42766924
71Pallor (HP:0000980)2.42550469
72Secondary amenorrhea (HP:0000869)2.42025860
73Chronic otitis media (HP:0000389)2.41239802
74Cystic liver disease (HP:0006706)2.39988151
75Acute necrotizing encephalopathy (HP:0006965)2.38660986
76Prolonged bleeding time (HP:0003010)2.36902964
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.32971047
78Neutropenia (HP:0001875)2.32729467
79Tubular atrophy (HP:0000092)2.32682590
80Entropion (HP:0000621)2.32399891
81Stomach cancer (HP:0012126)2.31949382
82Enlarged penis (HP:0000040)2.30366163
833-Methylglutaconic aciduria (HP:0003535)2.30288016
84Lymphopenia (HP:0001888)2.29980366
85Recurrent cutaneous fungal infections (HP:0011370)2.29863399
86Chronic mucocutaneous candidiasis (HP:0002728)2.29863399
87T lymphocytopenia (HP:0005403)2.27801461
88Retinal dysplasia (HP:0007973)2.26250708
89Abnormality of T cell number (HP:0011839)2.23914867
90Recurrent bronchitis (HP:0002837)2.23660664
91Encephalitis (HP:0002383)2.22482767
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22441075
93Mitochondrial inheritance (HP:0001427)2.21912767
94Lissencephaly (HP:0001339)2.21805968
95Progressive macrocephaly (HP:0004481)2.21497090
96Small epiphyses (HP:0010585)2.20208272
97Inability to walk (HP:0002540)2.20202537
98Chronic obstructive pulmonary disease (HP:0006510)2.19826564
99Obstructive lung disease (HP:0006536)2.19826564
100Abnormality of B cell number (HP:0010975)2.19445623
101B lymphocytopenia (HP:0010976)2.19445623
102Increased CSF lactate (HP:0002490)2.18801265
103CNS hypomyelination (HP:0003429)2.18103629
104Basal cell carcinoma (HP:0002671)2.18009876
105Reduced antithrombin III activity (HP:0001976)2.17140320
106Polyuria (HP:0000103)2.17056451
107Acute encephalopathy (HP:0006846)2.16597927
108Methylmalonic acidemia (HP:0002912)2.15975347
109Large for gestational age (HP:0001520)2.15037132
110Generalized hypopigmentation of hair (HP:0011358)2.13691300
111Severe combined immunodeficiency (HP:0004430)2.13222328
112Progressive inability to walk (HP:0002505)2.10160692
113Sclerocornea (HP:0000647)2.09459736
114Colon cancer (HP:0003003)2.08427148
115Optic nerve coloboma (HP:0000588)2.07978609
116Gait imbalance (HP:0002141)2.07705250
117Combined immunodeficiency (HP:0005387)2.07314965
118Abnormal mitochondria in muscle tissue (HP:0008316)2.06380342
119Granulocytopenia (HP:0001913)2.06240667
120Megaloblastic anemia (HP:0001889)2.06109163
121Pustule (HP:0200039)2.05754851
122Congenital primary aphakia (HP:0007707)2.05223792
123Furrowed tongue (HP:0000221)2.04836670
124Abnormal protein glycosylation (HP:0012346)2.04790676
125Abnormal glycosylation (HP:0012345)2.04790676
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04790676
127Abnormal protein N-linked glycosylation (HP:0012347)2.04790676
128Hypomagnesemia (HP:0002917)2.02782373
129Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02740109
130Methylmalonic aciduria (HP:0012120)2.00967056
131Absent speech (HP:0001344)1.99071965
132Nephrogenic diabetes insipidus (HP:0009806)1.98788118
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.98694526
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98641053
135Patellar aplasia (HP:0006443)1.98554516
136Myositis (HP:0100614)1.98353300
137Cerebellar dysplasia (HP:0007033)1.98323262
138Abnormality of the pons (HP:0007361)1.97961645
139Abnormality of the preputium (HP:0100587)1.95961804
140Verrucae (HP:0200043)1.95488761
141Papilloma (HP:0012740)1.95488761
142Oligodactyly (hands) (HP:0001180)1.95448088
143Hypothermia (HP:0002045)1.95243675
144Hypoplasia of the pons (HP:0012110)1.94767444
145Increased corneal curvature (HP:0100692)1.93409035
146Keratoconus (HP:0000563)1.93409035
147Neoplasm of the pancreas (HP:0002894)1.92901181
148Poikiloderma (HP:0001029)1.92890736
149Epistaxis (HP:0000421)1.92245530
150Recurrent abscess formation (HP:0002722)1.92107961
151Concave nail (HP:0001598)1.91937828
152Congenital hepatic fibrosis (HP:0002612)1.91405383
153Decreased circulating renin level (HP:0003351)1.90493623
154Optic disc pallor (HP:0000543)1.90012769
155Gaze-evoked nystagmus (HP:0000640)1.89699095
156Constricted visual fields (HP:0001133)1.89503232
157Pachygyria (HP:0001302)1.89321983
158Abnormality of eosinophils (HP:0001879)1.87838788
159Clumsiness (HP:0002312)1.87637632
160Selective tooth agenesis (HP:0001592)1.86655707
161Increased serum lactate (HP:0002151)1.86481883
162Aplasia/Hypoplasia of the patella (HP:0006498)1.85949269
163Sparse eyelashes (HP:0000653)1.85064021
164Severe muscular hypotonia (HP:0006829)1.84848303
165Absent thumb (HP:0009777)1.84190166
166Eosinophilia (HP:0001880)1.83057092
167Premature ovarian failure (HP:0008209)1.82987642
168Absent epiphyses (HP:0010577)1.82966250
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82966250
170Progressive microcephaly (HP:0000253)1.82188722
171Gonadotropin excess (HP:0000837)1.82066493
172Hepatocellular necrosis (HP:0001404)1.81636257
173Anencephaly (HP:0002323)1.81221772
174Bony spicule pigmentary retinopathy (HP:0007737)1.79569268
175Aplasia/Hypoplasia of the uvula (HP:0010293)1.79135980
176Degeneration of the lateral corticospinal tracts (HP:0002314)1.78815855
177Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78815855
178Hepatic necrosis (HP:0002605)1.78221155
179Type 2 muscle fiber atrophy (HP:0003554)1.76261413
180Broad-based gait (HP:0002136)1.73241367
181Male pseudohermaphroditism (HP:0000037)1.72322892
182Decreased central vision (HP:0007663)1.72294411
183Albinism (HP:0001022)1.71857576
184Dynein arm defect of respiratory motile cilia (HP:0012255)1.68205988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34559792
2BUB14.07963905
3WEE13.95008596
4BCKDK3.89648914
5MAP4K13.23126641
6ADRBK23.16013894
7MAP4K23.01284482
8BMPR1B2.75457989
9STK162.64540413
10EIF2AK12.61709084
11ACVR1B2.42971892
12WNK42.41672609
13PDK22.36459699
14INSRR2.33099991
15TAOK32.32990978
16TSSK62.31429464
17WNK32.19974455
18NME22.11384872
19GRK12.10838726
20NUAK12.07158850
21PINK12.04956062
22VRK12.01110078
23EIF2AK31.88364375
24CAMKK21.81278351
25CDC71.72506266
26CASK1.71523837
27NEK21.67815692
28STK101.67716040
29PASK1.63909451
30RPS6KB21.59116632
31BTK1.55643836
32TXK1.55352424
33OXSR11.54814801
34MAPK131.53314380
35BRSK21.49154062
36DYRK31.48862481
37SCYL21.44232442
38CAMK1D1.43490235
39DAPK21.40801619
40CLK11.40115112
41MKNK11.38398461
42KDR1.37220823
43SRPK11.36909062
44MAP3K41.35131497
45ZAP701.34701734
46STK391.29946023
47ZAK1.28151008
48GRK61.22305955
49ATR1.21223440
50TGFBR11.21158980
51RPS6KA41.18243153
52MKNK21.18132193
53TYK21.17767740
54PIM11.16216081
55TEC1.16187492
56TESK21.15419089
57CDK71.15340735
58IRAK41.12821631
59CDK41.11426099
60MAPKAPK31.10353866
61BLK1.10246037
62CAMK1G1.08181737
63KIT1.07459737
64PIM21.06310456
65ADRBK11.05963016
66MAP3K81.05076780
67STK41.05014238
68PLK11.04062303
69CDK191.00266262
70TTK0.99169680
71SYK0.98199882
72PAK30.97129925
73TLK10.96175550
74TRIM280.95615173
75JAK30.94343319
76AURKB0.93672557
77CSF1R0.92505287
78PNCK0.90551900
79MST40.90321462
80IKBKB0.88921183
81DYRK20.88908293
82CCNB10.87838280
83IRAK10.87817546
84IKBKE0.87127913
85PRKCG0.86247497
86CHUK0.86183676
87NTRK30.85879709
88MAP2K70.85091099
89CDK80.84812130
90PLK40.84705701
91PIK3CA0.84393272
92PLK30.83413197
93LCK0.83267963
94LYN0.82501223
95MAP3K110.81294560
96CSNK1G10.79576904
97PRKCE0.77991511
98FGFR20.77410210
99MAP2K60.75809529
100DAPK10.71939618
101STK240.71441698
102MAP3K100.71041806
103PRKCQ0.68941976
104BRSK10.68831671
105PHKG10.68675817
106PHKG20.68675817
107ITK0.67968844
108CSNK1G20.66581969
109CHEK20.65570563
110TAOK20.64182989
111STK38L0.62858376
112CSNK1A1L0.62336785
113MAP2K30.61142156
114EEF2K0.59890599
115CHEK10.58968117
116AURKA0.58549261
117PTK2B0.58498614
118CSNK2A20.58224602
119STK110.57705358
120SIK30.55399559
121RPS6KA50.55237120
122VRK20.54666410
123TNIK0.54619685
124CAMK10.54394187
125EPHA20.53427169
126CSNK2A10.52631954
127PLK20.51818263
128EIF2AK20.48319721
129MAPKAPK50.47980174
130TBK10.47635999
131STK30.47370454
132LRRK20.47362848
133BCR0.46439576
134CSNK1A10.45866441
135PAK40.45829638
136MAP3K30.45277975
137TIE10.43704349
138PRKAA10.43328016
139CSNK1G30.42446075
140CDK20.42219821
141NME10.41070073
142PBK0.40346662
143ABL20.39967949
144MAPK150.39571264
145CSNK1D0.39001212
146ATM0.38227011
147PRKACA0.37853388
148TESK10.37241394
149FLT30.36947774
150GRK70.36374393
151FES0.34417245
152MAPK120.34328191
153ALK0.34251699
154NLK0.34241267
155PRKCI0.33754435
156PDK40.33553978
157PDK30.33553978
158MAPK70.33029930
159MARK10.32906632
160CAMK40.32510235
161SIK20.32317389
162TNK20.31758037
163NEK10.31606386

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47342936
2Ribosome_Homo sapiens_hsa030103.70419318
3Mismatch repair_Homo sapiens_hsa034303.61907607
4RNA polymerase_Homo sapiens_hsa030203.57064165
5Proteasome_Homo sapiens_hsa030503.26094862
6Nitrogen metabolism_Homo sapiens_hsa009103.23623369
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12597679
8Spliceosome_Homo sapiens_hsa030402.97223523
9Base excision repair_Homo sapiens_hsa034102.94977630
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.78390976
11Phototransduction_Homo sapiens_hsa047442.62979711
12Pyrimidine metabolism_Homo sapiens_hsa002402.57402606
13RNA transport_Homo sapiens_hsa030132.50346730
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.42032106
15Linoleic acid metabolism_Homo sapiens_hsa005912.41130873
16Nucleotide excision repair_Homo sapiens_hsa034202.39071538
17Protein export_Homo sapiens_hsa030602.31566111
18Homologous recombination_Homo sapiens_hsa034402.23925689
19Primary immunodeficiency_Homo sapiens_hsa053402.23521652
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02267770
21Cell cycle_Homo sapiens_hsa041101.98960374
22Basal transcription factors_Homo sapiens_hsa030221.94834855
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87737250
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85671481
25Ether lipid metabolism_Homo sapiens_hsa005651.83129013
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82789512
27Caffeine metabolism_Homo sapiens_hsa002321.82772374
28Butanoate metabolism_Homo sapiens_hsa006501.81409063
29RNA degradation_Homo sapiens_hsa030181.79928176
30One carbon pool by folate_Homo sapiens_hsa006701.78971253
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75743412
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71497512
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70519758
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69830129
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68299514
36Vitamin B6 metabolism_Homo sapiens_hsa007501.62314044
37Antigen processing and presentation_Homo sapiens_hsa046121.61329306
38Fanconi anemia pathway_Homo sapiens_hsa034601.59865838
39Purine metabolism_Homo sapiens_hsa002301.58137481
40Peroxisome_Homo sapiens_hsa041461.46094065
41Folate biosynthesis_Homo sapiens_hsa007901.44502734
42Non-homologous end-joining_Homo sapiens_hsa034501.43214092
43Pentose phosphate pathway_Homo sapiens_hsa000301.39248053
44Epstein-Barr virus infection_Homo sapiens_hsa051691.34408450
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.34180591
46p53 signaling pathway_Homo sapiens_hsa041151.33013376
47Tryptophan metabolism_Homo sapiens_hsa003801.32593567
48Type I diabetes mellitus_Homo sapiens_hsa049401.26717595
49Herpes simplex infection_Homo sapiens_hsa051681.23092854
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20737518
51Regulation of autophagy_Homo sapiens_hsa041401.16625852
52Propanoate metabolism_Homo sapiens_hsa006401.14883173
53Nicotine addiction_Homo sapiens_hsa050331.10324136
54Measles_Homo sapiens_hsa051621.08988903
55Insulin secretion_Homo sapiens_hsa049111.05304294
56Asthma_Homo sapiens_hsa053101.03438450
57Arachidonic acid metabolism_Homo sapiens_hsa005900.98701514
58B cell receptor signaling pathway_Homo sapiens_hsa046620.95294306
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95120671
60Alzheimers disease_Homo sapiens_hsa050100.93020995
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91590523
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89849942
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.89364563
64Ovarian steroidogenesis_Homo sapiens_hsa049130.89307201
65N-Glycan biosynthesis_Homo sapiens_hsa005100.89027870
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88685735
67Olfactory transduction_Homo sapiens_hsa047400.88566747
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87887287
69mRNA surveillance pathway_Homo sapiens_hsa030150.86138601
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.85810543
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.85347516
72Collecting duct acid secretion_Homo sapiens_hsa049660.84928361
73beta-Alanine metabolism_Homo sapiens_hsa004100.84592308
74Morphine addiction_Homo sapiens_hsa050320.84154438
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83568373
76Selenocompound metabolism_Homo sapiens_hsa004500.82034015
77Taste transduction_Homo sapiens_hsa047420.80045359
78ABC transporters_Homo sapiens_hsa020100.79964182
79Shigellosis_Homo sapiens_hsa051310.77687716
80Leishmaniasis_Homo sapiens_hsa051400.76465035
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76182101
82Hematopoietic cell lineage_Homo sapiens_hsa046400.75795199
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75161139
84Legionellosis_Homo sapiens_hsa051340.74035104
85Viral carcinogenesis_Homo sapiens_hsa052030.73945303
86Sulfur relay system_Homo sapiens_hsa041220.73115001
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70831509
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.69869011
89Fructose and mannose metabolism_Homo sapiens_hsa000510.68441073
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67673782
91T cell receptor signaling pathway_Homo sapiens_hsa046600.67464028
92Sulfur metabolism_Homo sapiens_hsa009200.67276602
93Galactose metabolism_Homo sapiens_hsa000520.64848036
94HTLV-I infection_Homo sapiens_hsa051660.64361847
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64182343
96* Apoptosis_Homo sapiens_hsa042100.64043814
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.63461299
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63160446
99Chemical carcinogenesis_Homo sapiens_hsa052040.57659891
100Serotonergic synapse_Homo sapiens_hsa047260.57330833
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56309506
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55989538
103Cardiac muscle contraction_Homo sapiens_hsa042600.52840706
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50332430
105Hepatitis B_Homo sapiens_hsa051610.49399604
106Fat digestion and absorption_Homo sapiens_hsa049750.48224410
107Glycerolipid metabolism_Homo sapiens_hsa005610.48210701
108GABAergic synapse_Homo sapiens_hsa047270.47538604
109Vitamin digestion and absorption_Homo sapiens_hsa049770.47047187
110Biosynthesis of amino acids_Homo sapiens_hsa012300.46635086
111Rheumatoid arthritis_Homo sapiens_hsa053230.45667569
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44175878
113Circadian entrainment_Homo sapiens_hsa047130.44084186
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43613057
115Retinol metabolism_Homo sapiens_hsa008300.42138135
116Systemic lupus erythematosus_Homo sapiens_hsa053220.41610139
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41366409
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41327693
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41063912
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40430653
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.39475699
122Allograft rejection_Homo sapiens_hsa053300.39415641
123Huntingtons disease_Homo sapiens_hsa050160.38071238
124Thyroid cancer_Homo sapiens_hsa052160.37054366
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36368372
126Renin-angiotensin system_Homo sapiens_hsa046140.35444885
127Fatty acid degradation_Homo sapiens_hsa000710.35428455
128Oocyte meiosis_Homo sapiens_hsa041140.35150858
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35126218
130Acute myeloid leukemia_Homo sapiens_hsa052210.34152642
131Calcium signaling pathway_Homo sapiens_hsa040200.33566434
132Circadian rhythm_Homo sapiens_hsa047100.33303096
133Influenza A_Homo sapiens_hsa051640.32077178
134Osteoclast differentiation_Homo sapiens_hsa043800.31003626
135Glutamatergic synapse_Homo sapiens_hsa047240.30110021
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29637776
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28876337
138Parkinsons disease_Homo sapiens_hsa050120.27828262
139Metabolic pathways_Homo sapiens_hsa011000.27777462
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27297916
141Viral myocarditis_Homo sapiens_hsa054160.26617429
142Small cell lung cancer_Homo sapiens_hsa052220.26419952
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26082024
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22419553
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21816757
146Pertussis_Homo sapiens_hsa051330.21193335
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20861889
148Notch signaling pathway_Homo sapiens_hsa043300.20684317
149Carbon metabolism_Homo sapiens_hsa012000.20057889
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19907240
151Oxidative phosphorylation_Homo sapiens_hsa001900.19356357
152Glutathione metabolism_Homo sapiens_hsa004800.19005055
153Autoimmune thyroid disease_Homo sapiens_hsa053200.18753396
154Graft-versus-host disease_Homo sapiens_hsa053320.15969415
155Tuberculosis_Homo sapiens_hsa051520.14650094

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »