DFFBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.34839764
2definitive hemopoiesis (GO:0060216)5.21049863
3positive regulation of cellular amide metabolic process (GO:0034250)4.96417179
4positive regulation of B cell differentiation (GO:0045579)4.82653177
5positive regulation of gamma-delta T cell activation (GO:0046645)4.68431669
6nuclear pore complex assembly (GO:0051292)4.44437331
7energy homeostasis (GO:0097009)4.30773092
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01093870
9imidazole-containing compound metabolic process (GO:0052803)3.90737166
10modulation by symbiont of host defense response (GO:0052031)3.88918566
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88918566
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88918566
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.88918566
14modulation by symbiont of host immune response (GO:0052553)3.88918566
15positive regulation by symbiont of host defense response (GO:0052509)3.88918566
16regulation of beta-amyloid formation (GO:1902003)3.88165026
17regulation of gamma-delta T cell differentiation (GO:0045586)3.65414670
18B cell receptor signaling pathway (GO:0050853)3.55805608
19histamine secretion (GO:0001821)3.55011705
20regulation of B cell differentiation (GO:0045577)3.51063781
21regulation of glucocorticoid metabolic process (GO:0031943)3.50245831
223-UTR-mediated mRNA stabilization (GO:0070935)3.44788390
23regulation of gamma-delta T cell activation (GO:0046643)3.38631772
24regulation of histone H3-K27 methylation (GO:0061085)3.36794026
25nuclear pore organization (GO:0006999)3.26672518
26poly(A)+ mRNA export from nucleus (GO:0016973)3.22507093
27regulation of amyloid precursor protein catabolic process (GO:1902991)3.20599569
28positive thymic T cell selection (GO:0045059)3.16811703
29response to muramyl dipeptide (GO:0032495)3.14776481
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12870160
31glucocorticoid receptor signaling pathway (GO:0042921)3.10188123
32zinc ion homeostasis (GO:0055069)3.06059847
33corticosteroid receptor signaling pathway (GO:0031958)3.05651303
34histone H3-K9 demethylation (GO:0033169)3.05002448
35pore complex assembly (GO:0046931)3.04957183
36regulation of B cell receptor signaling pathway (GO:0050855)3.04093298
37response to peptidoglycan (GO:0032494)3.03583298
38positive regulation of amino acid transport (GO:0051957)3.02270161
39histone demethylation (GO:0016577)3.01181162
40regulation of mast cell degranulation (GO:0043304)2.99678903
41protein targeting to Golgi (GO:0000042)2.99664471
42histone lysine demethylation (GO:0070076)2.99638431
43establishment of protein localization to Golgi (GO:0072600)2.98170994
44regulation of erythrocyte differentiation (GO:0045646)2.95192236
45macrophage activation involved in immune response (GO:0002281)2.95048537
46positive regulation of granulocyte differentiation (GO:0030854)2.93105644
47histone H3-K36 demethylation (GO:0070544)2.92848464
48negative regulation of bone resorption (GO:0045779)2.87432132
49regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.86540897
50protein demethylation (GO:0006482)2.86337987
51protein dealkylation (GO:0008214)2.86337987
52myeloid cell development (GO:0061515)2.84672453
53regulation of B cell apoptotic process (GO:0002902)2.81819267
54regulation of mast cell activation involved in immune response (GO:0033006)2.77706201
55positive regulation of DNA-dependent DNA replication (GO:2000105)2.75163499
56regulation of cellular amide metabolic process (GO:0034248)2.74317812
57erythrocyte maturation (GO:0043249)2.74283072
58histamine transport (GO:0051608)2.72194216
59positive T cell selection (GO:0043368)2.71434176
60thymic T cell selection (GO:0045061)2.69778645
61granulocyte differentiation (GO:0030851)2.68567007
62regulation of interferon-beta biosynthetic process (GO:0045357)2.67512771
63negative regulation of acute inflammatory response (GO:0002674)2.65654301
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64745342
65DNA unwinding involved in DNA replication (GO:0006268)2.61616650
66regulation of leukocyte degranulation (GO:0043300)2.61051553
67protoporphyrinogen IX metabolic process (GO:0046501)2.59893590
68cellular response to thyroid hormone stimulus (GO:0097067)2.59879251
69negative thymic T cell selection (GO:0045060)2.58453892
70negative regulation of alcohol biosynthetic process (GO:1902931)2.56527597
71potassium ion export (GO:0071435)2.55419829
72neutrophil activation involved in immune response (GO:0002283)2.54610879
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53029363
74response to host immune response (GO:0052572)2.53029363
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50869212
76negative regulation of cell killing (GO:0031342)2.50869212
77vitamin transmembrane transport (GO:0035461)2.50337085
78cellular extravasation (GO:0045123)2.48465731
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47478823
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46109105
81response to host (GO:0075136)2.46109105
82response to host defenses (GO:0052200)2.46109105
83regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45759217
84cytoplasmic mRNA processing body assembly (GO:0033962)2.45201732
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.43950519
86T cell selection (GO:0045058)2.43471609
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42424725
88megakaryocyte development (GO:0035855)2.41733830
89regulation of mast cell activation (GO:0033003)2.40082048
90regulation of necroptotic process (GO:0060544)2.39931301
91negative regulation of type 2 immune response (GO:0002829)2.39869349
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39713726
93negative regulation of amino acid transport (GO:0051956)2.39333963
94leukocyte aggregation (GO:0070486)2.39050604
95oligosaccharide catabolic process (GO:0009313)2.38585505
96peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.37913160
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.37859442
98immunoglobulin mediated immune response (GO:0016064)2.36363072
99hyaluronan catabolic process (GO:0030214)2.36212840
100antigen processing and presentation of endogenous antigen (GO:0019883)2.35678520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.02530348
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82950209
3MYC_22102868_ChIP-Seq_BL_Human3.80441717
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.48309072
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.07658044
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98533382
7SCL_19346495_ChIP-Seq_HPC-7_Human2.96955255
8VDR_21846776_ChIP-Seq_THP-1_Human2.88103462
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70079437
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64170910
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50689881
12MAF_26560356_Chip-Seq_TH1_Human2.49907205
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42522790
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31368296
15MYB_26560356_Chip-Seq_TH1_Human2.30274916
16MYB_26560356_Chip-Seq_TH2_Human2.26059041
17TCF7_22412390_ChIP-Seq_EML_Mouse2.23532295
18GATA1_22025678_ChIP-Seq_K562_Human2.18444520
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15765620
20CIITA_25753668_ChIP-Seq_RAJI_Human2.15536128
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09887647
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09328697
23SPI1_23547873_ChIP-Seq_NB4_Human2.07107013
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06590797
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05772473
26VDR_24763502_ChIP-Seq_THP-1_Human2.02584659
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01918755
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.98322254
29TFEB_21752829_ChIP-Seq_HELA_Human1.98189935
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97983602
31KDM2B_26808549_Chip-Seq_DND41_Human1.97966316
32UTX_26944678_Chip-Seq_JUKART_Human1.93540776
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92525947
34SPI1_23127762_ChIP-Seq_K562_Human1.90493903
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.89201612
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83077455
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81276334
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78462867
39MAF_26560356_Chip-Seq_TH2_Human1.72050893
40GATA1_19941826_ChIP-Seq_K562_Human1.71721863
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.71550957
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69091061
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68525891
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63256727
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62639988
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58055676
47ZNF263_19887448_ChIP-Seq_K562_Human1.57725698
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56940488
49NCOR1_26117541_ChIP-Seq_K562_Human1.56397544
50GATA3_27048872_Chip-Seq_THYMUS_Human1.50603234
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48997095
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47537100
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44197316
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43612174
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42858012
56RUNX_20019798_ChIP-Seq_JUKART_Human1.42822352
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42251222
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40630927
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39787906
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37627585
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.36971498
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34562725
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.33968258
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32066615
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31968373
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31068996
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.28853731
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28767102
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26908734
70GATA2_19941826_ChIP-Seq_K562_Human1.26559656
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25755683
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25664139
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.25458149
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22796122
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18940542
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18570954
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15581994
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13409878
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.12520433
80PU_27001747_Chip-Seq_BMDM_Mouse1.12505593
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.10754949
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10299037
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06884845
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06550131
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06469782
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.05540695
87ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03101500
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00271570
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00143243
90TP63_19390658_ChIP-ChIP_HaCaT_Human0.99565864
91KDM5A_27292631_Chip-Seq_BREAST_Human0.99466437
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.97885760
93GATA3_26560356_Chip-Seq_TH2_Human0.97361858
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97061028
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93663884
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.93367001
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93020789
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90477152
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90009259
100FOXP3_21729870_ChIP-Seq_TREG_Human0.89171901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001545_abnormal_hematopoietic_system3.68526153
2MP0005397_hematopoietic_system_phenotyp3.68526153
3MP0003656_abnormal_erythrocyte_physiolo3.44869345
4MP0003191_abnormal_cellular_cholesterol3.17677012
5MP0005451_abnormal_body_composition3.07408085
6MP0009278_abnormal_bone_marrow3.04174536
7MP0003763_abnormal_thymus_physiology3.04053276
8MP0008057_abnormal_DNA_replication2.59658242
9MP0003436_decreased_susceptibility_to2.59012321
10MP0002396_abnormal_hematopoietic_system2.54921025
11MP0004808_abnormal_hematopoietic_stem2.53503062
12MP0002822_catalepsy2.53389618
13MP0002009_preneoplasia2.52306599
14MP0000372_irregular_coat_pigmentation2.46919857
15MP0008961_abnormal_basal_metabolism2.29796653
16MP0001835_abnormal_antigen_presentation2.12920341
17MP0002132_abnormal_respiratory_system2.02905308
18MP0005409_darkened_coat_color1.97394396
19MP0002166_altered_tumor_susceptibility1.95328180
20MP0009333_abnormal_splenocyte_physiolog1.91250222
21MP0002398_abnormal_bone_marrow1.80482436
22MP0003303_peritoneal_inflammation1.75614393
23MP0000703_abnormal_thymus_morphology1.66724476
24MP0005464_abnormal_platelet_physiology1.61820912
25MP0002722_abnormal_immune_system1.60807676
26MP0008260_abnormal_autophagy1.60725652
27MP0002419_abnormal_innate_immunity1.60137068
28MP0003300_gastrointestinal_ulcer1.57996595
29MP0003172_abnormal_lysosome_physiology1.57082925
30MP0002420_abnormal_adaptive_immunity1.55101643
31MP0001800_abnormal_humoral_immune1.54504922
32MP0005000_abnormal_immune_tolerance1.54138794
33MP0000689_abnormal_spleen_morphology1.51950047
34MP0001819_abnormal_immune_cell1.51818767
35MP0002723_abnormal_immune_serum1.50096844
36MP0000716_abnormal_immune_system1.45554746
37MP0010094_abnormal_chromosome_stability1.45167873
38MP0009697_abnormal_copulation1.41881850
39MP0000015_abnormal_ear_pigmentation1.39662658
40MP0002429_abnormal_blood_cell1.37905118
41MP0002452_abnormal_antigen_presenting1.37583099
42MP0000465_gastrointestinal_hemorrhage1.36690152
43MP0005025_abnormal_response_to1.34527944
44MP0002405_respiratory_system_inflammati1.33922063
45MP0004381_abnormal_hair_follicle1.29250954
46MP0004947_skin_inflammation1.24951357
47MP0000685_abnormal_immune_system1.23447125
48MP0009840_abnormal_foam_cell1.20612944
49MP0001873_stomach_inflammation1.20442904
50MP0002998_abnormal_bone_remodeling1.18240552
51MP0010352_gastrointestinal_tract_polyps1.18168459
52MP0000003_abnormal_adipose_tissue1.17545712
53MP0005379_endocrine/exocrine_gland_phen1.16232687
54MP0003693_abnormal_embryo_hatching1.15720717
55MP0003943_abnormal_hepatobiliary_system1.13194384
56MP0002006_tumorigenesis1.10555351
57MP0003183_abnormal_peptide_metabolism1.08009275
58MP0004233_abnormal_muscle_weight1.06541563
59MP0005058_abnormal_lysosome_morphology1.06006150
60MP0005076_abnormal_cell_differentiation1.03592225
61MP0000013_abnormal_adipose_tissue1.01701488
62MP0001790_abnormal_immune_system0.99367781
63MP0005387_immune_system_phenotype0.99367781
64MP0009765_abnormal_xenobiotic_induced0.97785964
65MP0005075_abnormal_melanosome_morpholog0.96008293
66MP0002019_abnormal_tumor_incidence0.94570878
67MP0003077_abnormal_cell_cycle0.93102648
68MP0005375_adipose_tissue_phenotype0.92616118
69MP0005083_abnormal_biliary_tract0.91236425
70MP0005410_abnormal_fertilization0.90415409
71MP0000678_abnormal_parathyroid_gland0.89993159
72MP0008995_early_reproductive_senescence0.89831778
73MP0005671_abnormal_response_to0.88703675
74MP0002970_abnormal_white_adipose0.88268282
75MP0001851_eye_inflammation0.87698671
76MP0009115_abnormal_fat_cell0.86810962
77MP0001533_abnormal_skeleton_physiology0.84567652
78MP0009785_altered_susceptibility_to0.83891151
79MP0001845_abnormal_inflammatory_respons0.83449613
80MP0000490_abnormal_crypts_of0.83084672
81MP0003111_abnormal_nucleus_morphology0.82665052
82MP0005266_abnormal_metabolism0.82055533
83MP0009931_abnormal_skin_appearance0.80648755
84MP0005220_abnormal_exocrine_pancreas0.79562578
85MP0003724_increased_susceptibility_to0.79427239
86MP0001727_abnormal_embryo_implantation0.77567933
87MP0004782_abnormal_surfactant_physiolog0.77476506
88MP0002877_abnormal_melanocyte_morpholog0.76473282
89MP0010155_abnormal_intestine_physiology0.75235449
90MP0005167_abnormal_blood-brain_barrier0.74351033
91MP0009764_decreased_sensitivity_to0.73642219
92MP0005666_abnormal_adipose_tissue0.73224151
93MP0003786_premature_aging0.72058234
94MP0000350_abnormal_cell_proliferation0.70877988
95MP0000598_abnormal_liver_morphology0.69374866
96MP0008007_abnormal_cellular_replicative0.68445097
97MP0005645_abnormal_hypothalamus_physiol0.68079304
98MP0008469_abnormal_protein_level0.66586478
99MP0001348_abnormal_lacrimal_gland0.66271895
100MP0000609_abnormal_liver_physiology0.65974475

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)5.32489331
2Stomatitis (HP:0010280)4.63059861
3Fatigue (HP:0012378)4.58869988
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.44178232
5Menstrual irregularities (HP:0000858)3.97722723
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.93909927
7Abnormality of the fingertips (HP:0001211)3.92346236
8Recurrent bacterial skin infections (HP:0005406)3.14757914
9Abnormality of the thoracic spine (HP:0100711)3.06926008
10Thrombocytosis (HP:0001894)3.06667104
11Progressive muscle weakness (HP:0003323)3.00306923
12Panhypogammaglobulinemia (HP:0003139)2.97834909
13Abnormality of liposaccharide metabolism (HP:0010968)2.96938117
14Abnormality of glycosphingolipid metabolism (HP:0004343)2.96938117
15Abnormality of glycolipid metabolism (HP:0010969)2.96938117
16Prominent nose (HP:0000448)2.94192765
17Recurrent viral infections (HP:0004429)2.91177285
18Thoracic kyphosis (HP:0002942)2.88570248
19Reticulocytosis (HP:0001923)2.88471794
20Recurrent abscess formation (HP:0002722)2.82330921
21Prostate neoplasm (HP:0100787)2.78966684
22Polycythemia (HP:0001901)2.78110790
23Prolonged bleeding time (HP:0003010)2.74504543
24Peripheral hypomyelination (HP:0007182)2.63262467
25Increased serum ferritin (HP:0003281)2.54821735
26Abnormality of iron homeostasis (HP:0011031)2.54308176
27Viral hepatitis (HP:0006562)2.49852180
28Acute hepatic failure (HP:0006554)2.46790613
29Abnormality of the right ventricle (HP:0001707)2.45185074
30Hepatitis (HP:0012115)2.41667249
31Asymmetry of the thorax (HP:0001555)2.38511011
32Abnormality of the prostate (HP:0008775)2.33843814
33Abnormality of the sella turcica (HP:0002679)2.33006614
34Stomach cancer (HP:0012126)2.29313815
35Petechiae (HP:0000967)2.28288589
36Arterial thrombosis (HP:0004420)2.27505339
37Tubulointerstitial nephritis (HP:0001970)2.26711791
38Recurrent fungal infections (HP:0002841)2.26333699
39Neurodegeneration (HP:0002180)2.24684792
40Truncal obesity (HP:0001956)2.20036593
41Cutaneous melanoma (HP:0012056)2.19417320
42Poikilocytosis (HP:0004447)2.18118095
43Acute myeloid leukemia (HP:0004808)2.17836843
44Cellulitis (HP:0100658)2.17480677
45Abnormality of transition element cation homeostasis (HP:0011030)2.16089364
46Increased IgE level (HP:0003212)2.12747991
47Spontaneous hematomas (HP:0007420)2.10845708
48Abnormality of the columella (HP:0009929)2.08783770
49Epistaxis (HP:0000421)2.07942270
50Deformed sella turcica (HP:0002681)2.07056893
51Granulocytopenia (HP:0001913)2.05739684
52Abnormality of homocysteine metabolism (HP:0010919)2.02401914
53Homocystinuria (HP:0002156)2.02401914
54Eczematoid dermatitis (HP:0000976)2.01979054
55Urinary glycosaminoglycan excretion (HP:0003541)2.01805229
56Mucopolysacchariduria (HP:0008155)2.01805229
57Abnormal delayed hypersensitivity skin test (HP:0002963)1.98250569
58Abnormality of macrophages (HP:0004311)1.97879170
59Abnormality of male internal genitalia (HP:0000022)1.96463303
60Dysmetric saccades (HP:0000641)1.95614972
61Chest pain (HP:0100749)1.95289950
62Somatic mutation (HP:0001428)1.94046212
63Recurrent skin infections (HP:0001581)1.93133455
64Gastrointestinal inflammation (HP:0004386)1.91754098
65Abnormality of the lumbar spine (HP:0100712)1.89309416
66T lymphocytopenia (HP:0005403)1.89175566
67Colitis (HP:0002583)1.89041994
68Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87839641
69Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87839641
70Abnormality of polysaccharide metabolism (HP:0011012)1.87839641
71B lymphocytopenia (HP:0010976)1.86845525
72Gingival bleeding (HP:0000225)1.84340442
73Gingivitis (HP:0000230)1.83225196
74Meningitis (HP:0001287)1.81722957
75Episodic fever (HP:0001954)1.81522559
76Encephalitis (HP:0002383)1.80546539
77Chronic otitis media (HP:0000389)1.79879982
78Abnormality of methionine metabolism (HP:0010901)1.79448968
79Myelodysplasia (HP:0002863)1.79122329
80Inflammation of the large intestine (HP:0002037)1.79100272
81Sandal gap (HP:0001852)1.78569137
82Narrow palate (HP:0000189)1.76708687
83Autoimmune hemolytic anemia (HP:0001890)1.74790593
84Abnormality of T cell physiology (HP:0011840)1.74557693
85Asymmetric septal hypertrophy (HP:0001670)1.73033997
86Glucose intolerance (HP:0000833)1.71707715
87Abnormality of B cell number (HP:0010975)1.71510886
88Obstructive lung disease (HP:0006536)1.70749472
89Chronic obstructive pulmonary disease (HP:0006510)1.70749472
90Mediastinal lymphadenopathy (HP:0100721)1.70187669
91Abnormality of T cells (HP:0002843)1.69689743
92Metaphyseal dysplasia (HP:0100255)1.68798471
93Stridor (HP:0010307)1.68059371
94Abnormality of lateral ventricle (HP:0030047)1.66938979
95Abnormal hair whorl (HP:0010721)1.66035133
96Abnormality of T cell number (HP:0011839)1.65818865
97Progressive external ophthalmoplegia (HP:0000590)1.65586923
98Gastrointestinal infarctions (HP:0005244)1.64782346
99Osteomyelitis (HP:0002754)1.64514174
100Abnormality of endocrine pancreas physiology (HP:0012093)1.64159189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.40534493
2NME24.40457784
3SCYL23.32025468
4CDK123.26387856
5BRD42.98472237
6MAP4K12.84617323
7MAP2K32.43644823
8RIPK42.21319426
9FRK1.88071294
10PLK41.86804968
11MAP3K61.76967731
12SIK21.76040537
13GRK61.71770514
14CDK31.63527617
15BTK1.56999023
16TRIB31.54985729
17MARK31.53720895
18RPS6KA41.44232368
19MAP3K101.42198783
20MAP3K11.38612493
21ZAP701.35909320
22ERN11.28141774
23IRAK41.27014982
24SIK31.24303327
25SIK11.23684456
26FGFR31.23211484
27IRAK11.21890879
28MAP2K61.21550604
29TNK21.19625413
30FGFR21.18499131
31MAP3K141.18368744
32SYK1.16288100
33MAPK111.15923446
34PTK2B1.14507110
35IKBKE1.14044944
36TAOK21.09746417
37ICK1.08066849
38TEC1.07435920
39HCK1.04883076
40JAK31.04837840
41EEF2K1.02580072
42PDK11.01942403
43MAP3K21.01620781
44PIM11.01348015
45BLK0.97570269
46TRPM70.96248049
47MAP3K50.94905324
48HIPK20.94371474
49PDPK10.93641171
50MAP3K30.93121214
51JAK10.91892600
52PASK0.91710963
53CDK40.91610168
54TAOK30.90459756
55MELK0.87858263
56MARK20.84643878
57MTOR0.84567918
58IRAK30.84142855
59ITK0.82174705
60EPHB10.81827642
61NEK90.80798062
62TXK0.78240884
63CDK80.75837043
64CDK70.72396469
65JAK20.72282447
66MAP3K110.71319970
67EIF2AK10.70842092
68SMG10.70532282
69FES0.68818765
70TBK10.68790305
71CSNK1G30.68285969
72MAP2K40.67998550
73BCKDK0.65669247
74PIK3CG0.65663988
75MAP2K70.65221274
76LCK0.63722326
77IRAK20.63583106
78CAMK1D0.60018654
79LYN0.58696244
80IKBKB0.57692598
81PRKAA20.56614321
82CHEK10.53403882
83TYK20.52835991
84NEK20.52784752
85RET0.48040099
86CHUK0.48001815
87STK100.47577712
88CAMK1G0.47033783
89PRKCQ0.46818433
90STK380.45795483
91CDC70.45198600
92BMPR20.43325785
93RAF10.43045398
94PIM20.42568241
95RPS6KB10.41849074
96SGK30.38987605
97CDK90.38614781
98ATR0.37980842
99NEK60.37810698
100AKT10.37372133

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.96934552
2B cell receptor signaling pathway_Homo sapiens_hsa046622.56523351
3Non-small cell lung cancer_Homo sapiens_hsa052232.40826816
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.35318536
5Acute myeloid leukemia_Homo sapiens_hsa052212.09088757
6mTOR signaling pathway_Homo sapiens_hsa041502.06581609
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91937817
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91370083
9Hepatitis B_Homo sapiens_hsa051611.79049080
10Chronic myeloid leukemia_Homo sapiens_hsa052201.78104070
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66936064
12Leishmaniasis_Homo sapiens_hsa051401.61252761
13Osteoclast differentiation_Homo sapiens_hsa043801.60998122
14T cell receptor signaling pathway_Homo sapiens_hsa046601.53305899
15Graft-versus-host disease_Homo sapiens_hsa053321.45727755
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40809283
17Pancreatic cancer_Homo sapiens_hsa052121.37265215
18Herpes simplex infection_Homo sapiens_hsa051681.34278451
19Antigen processing and presentation_Homo sapiens_hsa046121.31639643
20Measles_Homo sapiens_hsa051621.30264784
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.29672778
22Lysine degradation_Homo sapiens_hsa003101.29221135
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28088565
24Inositol phosphate metabolism_Homo sapiens_hsa005621.26879114
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25772444
26Tuberculosis_Homo sapiens_hsa051521.25539283
27Influenza A_Homo sapiens_hsa051641.24665701
28Primary immunodeficiency_Homo sapiens_hsa053401.24054904
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23793376
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21707950
31VEGF signaling pathway_Homo sapiens_hsa043701.21529796
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20438156
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.15860457
34Endometrial cancer_Homo sapiens_hsa052131.13871252
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12876275
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.12553220
37Platelet activation_Homo sapiens_hsa046111.11453608
38Prolactin signaling pathway_Homo sapiens_hsa049171.06764045
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05677626
40Legionellosis_Homo sapiens_hsa051341.03318175
41Glioma_Homo sapiens_hsa052141.01487352
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99050623
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.97899490
44Viral carcinogenesis_Homo sapiens_hsa052030.96654668
45FoxO signaling pathway_Homo sapiens_hsa040680.95280057
46DNA replication_Homo sapiens_hsa030300.95230688
47Type II diabetes mellitus_Homo sapiens_hsa049300.95205389
48Prostate cancer_Homo sapiens_hsa052150.94820051
49Insulin resistance_Homo sapiens_hsa049310.94172306
50Toxoplasmosis_Homo sapiens_hsa051450.92486659
51TNF signaling pathway_Homo sapiens_hsa046680.91321376
52Small cell lung cancer_Homo sapiens_hsa052220.91306165
53Hepatitis C_Homo sapiens_hsa051600.91103836
54Pentose phosphate pathway_Homo sapiens_hsa000300.90467892
55Apoptosis_Homo sapiens_hsa042100.89911140
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87945472
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85924944
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83941359
59Cell cycle_Homo sapiens_hsa041100.82685650
60Regulation of autophagy_Homo sapiens_hsa041400.81533638
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81174405
62HTLV-I infection_Homo sapiens_hsa051660.80711124
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80650926
64ErbB signaling pathway_Homo sapiens_hsa040120.80582028
65Colorectal cancer_Homo sapiens_hsa052100.80038453
66Choline metabolism in cancer_Homo sapiens_hsa052310.79637441
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78348535
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77692825
69Hematopoietic cell lineage_Homo sapiens_hsa046400.77437232
70Shigellosis_Homo sapiens_hsa051310.77063527
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.76561885
72Type I diabetes mellitus_Homo sapiens_hsa049400.74472554
73Malaria_Homo sapiens_hsa051440.72389151
74Allograft rejection_Homo sapiens_hsa053300.71950446
75Epstein-Barr virus infection_Homo sapiens_hsa051690.71484361
76mRNA surveillance pathway_Homo sapiens_hsa030150.68421520
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67176424
78HIF-1 signaling pathway_Homo sapiens_hsa040660.66992323
79Renal cell carcinoma_Homo sapiens_hsa052110.66022083
80AMPK signaling pathway_Homo sapiens_hsa041520.65600903
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63815224
82Autoimmune thyroid disease_Homo sapiens_hsa053200.63679233
83Systemic lupus erythematosus_Homo sapiens_hsa053220.61608721
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61530314
85Lysosome_Homo sapiens_hsa041420.60652512
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.60635602
87Thyroid cancer_Homo sapiens_hsa052160.59743749
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59218523
89Sphingolipid metabolism_Homo sapiens_hsa006000.58672150
90GnRH signaling pathway_Homo sapiens_hsa049120.58253521
91Chemokine signaling pathway_Homo sapiens_hsa040620.58222442
92RNA transport_Homo sapiens_hsa030130.57783310
93Insulin signaling pathway_Homo sapiens_hsa049100.57192470
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.57085978
95Bladder cancer_Homo sapiens_hsa052190.55057044
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54297072
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54210798
98Notch signaling pathway_Homo sapiens_hsa043300.54049066
99Viral myocarditis_Homo sapiens_hsa054160.53705884
100Base excision repair_Homo sapiens_hsa034100.53705521

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