DGAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)5.82582317
2low-density lipoprotein particle clearance (GO:0034383)5.70731108
3intestinal absorption (GO:0050892)5.57680206
4fat-soluble vitamin biosynthetic process (GO:0042362)5.42621224
5intestinal cholesterol absorption (GO:0030299)5.28118171
6epoxygenase P450 pathway (GO:0019373)5.05710655
7fructose metabolic process (GO:0006000)5.04312653
8angiotensin maturation (GO:0002003)4.64468926
9regulation of cholesterol homeostasis (GO:2000188)4.53498462
10regulation of cellular extravasation (GO:0002691)4.41428681
11regulation of sequestering of triglyceride (GO:0010889)4.37822297
12regulation of triglyceride catabolic process (GO:0010896)4.36470783
13hormone catabolic process (GO:0042447)4.29411681
14positive regulation of p38MAPK cascade (GO:1900745)4.19749341
15positive regulation of guanylate cyclase activity (GO:0031284)4.18080746
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.16928223
17endocrine process (GO:0050886)4.16928223
18regulation of systemic arterial blood pressure by hormone (GO:0001990)4.16928223
19peptide catabolic process (GO:0043171)4.14295271
20urea cycle (GO:0000050)4.11606610
21tolerance induction (GO:0002507)4.10598950
22regulation of bile acid biosynthetic process (GO:0070857)4.05994525
23regulation of cholesterol storage (GO:0010885)4.03286167
24positive regulation of heat generation (GO:0031652)3.94631012
25urea metabolic process (GO:0019627)3.93105171
26virion attachment to host cell (GO:0019062)3.90319667
27adhesion of symbiont to host cell (GO:0044650)3.90319667
28antigen processing and presentation of endogenous antigen (GO:0019883)3.88707385
29valine metabolic process (GO:0006573)3.87545441
30triglyceride catabolic process (GO:0019433)3.86469767
31regulation of systemic arterial blood pressure (GO:0003073)3.83553233
32negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.82767610
33brown fat cell differentiation (GO:0050873)3.82606750
34positive regulation of fatty acid beta-oxidation (GO:0032000)3.79236891
35regulation of memory T cell differentiation (GO:0043380)3.71659868
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.70765793
37embryonic process involved in female pregnancy (GO:0060136)3.69330858
38positive regulation of lipid catabolic process (GO:0050996)3.65347302
39drug metabolic process (GO:0017144)3.64429728
40white fat cell differentiation (GO:0050872)3.63599913
41nitrogen cycle metabolic process (GO:0071941)3.63161663
42positive regulation of lipid storage (GO:0010884)3.63080329
43positive regulation of fatty acid oxidation (GO:0046321)3.63049225
44glycosphingolipid catabolic process (GO:0046479)3.60247851
45* diacylglycerol metabolic process (GO:0046339)3.59529512
46receptor guanylyl cyclase signaling pathway (GO:0007168)3.57626674
47adhesion of symbiont to host (GO:0044406)3.56497761
48negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.56238679
49regulation of cGMP biosynthetic process (GO:0030826)3.53882400
50glycolipid catabolic process (GO:0019377)3.52451775
51regulation of activation of Janus kinase activity (GO:0010533)3.50580846
52regulation of cholesterol esterification (GO:0010872)3.49978708
53antimicrobial humoral response (GO:0019730)3.49536380
54antibacterial humoral response (GO:0019731)3.45600117
55interferon-gamma production (GO:0032609)3.42982173
56positive regulation of triglyceride lipase activity (GO:0061365)3.42339296
57positive regulation of lipoprotein lipase activity (GO:0051006)3.42339296
58* triglyceride biosynthetic process (GO:0019432)3.42141769
59regulation of p38MAPK cascade (GO:1900744)3.41744882
60acylglycerol catabolic process (GO:0046464)3.41059199
61neutral lipid catabolic process (GO:0046461)3.41059199
62peptide hormone processing (GO:0016486)3.40706709
63positive regulation of triglyceride metabolic process (GO:0090208)3.39017809
64positive regulation of pseudopodium assembly (GO:0031274)3.37296938
65acylglycerol homeostasis (GO:0055090)3.36693755
66triglyceride homeostasis (GO:0070328)3.36693755
67biotin metabolic process (GO:0006768)3.35792175
68regulation of vitamin metabolic process (GO:0030656)3.34493787
69* lipid storage (GO:0019915)3.34469908
70NADH metabolic process (GO:0006734)3.32538689
71T-helper cell differentiation (GO:0042093)3.30721230
72CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.30721230
73renal system process involved in regulation of blood volume (GO:0001977)3.30287792
74GDP-mannose metabolic process (GO:0019673)3.29433664
75mature B cell differentiation involved in immune response (GO:0002313)3.29410773
76maintenance of gastrointestinal epithelium (GO:0030277)3.28694209
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.24047212
78regulation of triglyceride metabolic process (GO:0090207)3.21806784
79positive regulation of fatty acid metabolic process (GO:0045923)3.21711209
80* neutral lipid biosynthetic process (GO:0046460)3.20763704
81* acylglycerol biosynthetic process (GO:0046463)3.20763704
82pentose-phosphate shunt (GO:0006098)3.19991687
83regulation of fever generation (GO:0031620)3.18502151
84bile acid and bile salt transport (GO:0015721)3.15464495
85lipoprotein metabolic process (GO:0042157)3.15405615
86regulation of sterol transport (GO:0032371)3.12670611
87regulation of cholesterol transport (GO:0032374)3.12670611
88negative regulation of granulocyte differentiation (GO:0030853)3.12498634
89alkaloid metabolic process (GO:0009820)3.09625030
90fatty acid beta-oxidation (GO:0006635)3.06052643
91NADPH regeneration (GO:0006740)3.04577448
92regulation of podosome assembly (GO:0071801)3.04433945
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.02068110
94regulation of fatty acid beta-oxidation (GO:0031998)3.01690365
95flavonoid metabolic process (GO:0009812)3.01175419
96regulation of pseudopodium assembly (GO:0031272)3.00695875
97vitamin A metabolic process (GO:0006776)3.00664223
98negative regulation of lipid storage (GO:0010888)3.00170204
99negative regulation of protein autophosphorylation (GO:0031953)2.98054015
100cGMP-mediated signaling (GO:0019934)2.96197740
101fatty acid transmembrane transport (GO:1902001)2.95414479
102plasma lipoprotein particle remodeling (GO:0034369)2.95279640
103protein-lipid complex remodeling (GO:0034368)2.95279640
104macromolecular complex remodeling (GO:0034367)2.95279640
105phospholipid efflux (GO:0033700)2.93590846
106vitamin transport (GO:0051180)2.93266304
107nucleoside diphosphate biosynthetic process (GO:0009133)2.93176965
108regulation of macrophage derived foam cell differentiation (GO:0010743)2.92574120
109phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.89907716
110glutamine family amino acid biosynthetic process (GO:0009084)2.89803330
111leukotriene metabolic process (GO:0006691)2.89786909
112regulation of heat generation (GO:0031650)2.89723408
113regulation of cholesterol metabolic process (GO:0090181)2.89202491
114oligosaccharide catabolic process (GO:0009313)2.87847530
115plasma lipoprotein particle clearance (GO:0034381)2.86901464
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86330268
117regulation of fatty acid oxidation (GO:0046320)2.85600501
118regulation of lipid storage (GO:0010883)2.85586244
119* protein-lipid complex assembly (GO:0065005)2.85246310
120high-density lipoprotein particle remodeling (GO:0034375)2.85203737
121defense response to fungus (GO:0050832)2.84457532
122transcytosis (GO:0045056)2.84423948
123positive regulation of fatty acid biosynthetic process (GO:0045723)2.84343625
124vitamin transmembrane transport (GO:0035461)2.83536386
125carnitine shuttle (GO:0006853)2.82837561
126positive regulation of respiratory burst (GO:0060267)2.82703385
127ethanol oxidation (GO:0006069)2.81691140
128ceramide catabolic process (GO:0046514)2.81655643
129lipoprotein transport (GO:0042953)2.81242327
130growth hormone receptor signaling pathway (GO:0060396)2.80118990
131T cell differentiation involved in immune response (GO:0002292)2.80090800
132alpha-beta T cell differentiation involved in immune response (GO:0002293)2.80090800
133alpha-beta T cell activation involved in immune response (GO:0002287)2.80090800
134cellular response to zinc ion (GO:0071294)2.80032170
135regulation of cGMP metabolic process (GO:0030823)2.79465350
136regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.78789368
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78751912
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78751912
139regulation of extracellular matrix disassembly (GO:0010715)2.78314537
140arginine metabolic process (GO:0006525)2.78186609
141glucose 6-phosphate metabolic process (GO:0051156)2.77813196
142mannose metabolic process (GO:0006013)2.77639995
143digestion (GO:0007586)2.77015429
144leukocyte aggregation (GO:0070486)2.76437769
145NIK/NF-kappaB signaling (GO:0038061)2.73979032
146regulation of gamma-delta T cell differentiation (GO:0045586)2.73639740
147mucosal-associated lymphoid tissue development (GO:0048537)2.73482651
148Peyers patch development (GO:0048541)2.73482651
149* plasma lipoprotein particle assembly (GO:0034377)2.73445325
150positive regulation of histone deacetylation (GO:0031065)2.73276831
151carnitine transmembrane transport (GO:1902603)2.71986724
152detection of bacterium (GO:0016045)2.71799642
153fatty acid catabolic process (GO:0009062)2.71763998
154proline biosynthetic process (GO:0006561)2.70362289
155sphingolipid catabolic process (GO:0030149)2.69903336
156* triglyceride metabolic process (GO:0006641)2.69822336
157response to interleukin-15 (GO:0070672)2.69793047
158sexual reproduction (GO:0019953)2.68466807
159negative regulation of cell killing (GO:0031342)2.68310403
160negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68310403
161regulation of response to interferon-gamma (GO:0060330)2.68211514
162cellular response to reactive nitrogen species (GO:1902170)2.67968184
163fatty acid oxidation (GO:0019395)2.67102983
164tyrosine phosphorylation of STAT protein (GO:0007260)2.66822391
165regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.66628823
166cellular response to interleukin-15 (GO:0071350)2.66562128
167negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65347894
168homocysteine metabolic process (GO:0050667)2.64741098
169carnitine transport (GO:0015879)2.64709906
170amino-acid betaine transport (GO:0015838)2.64709906
171cellular response to nitric oxide (GO:0071732)2.64594310
172oxaloacetate metabolic process (GO:0006107)2.64367878
173cellular response to lithium ion (GO:0071285)2.63549517
174regulation of respiratory burst (GO:0060263)2.62595455
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62207269
176glycerol metabolic process (GO:0006071)2.61019805
177drug transport (GO:0015893)2.60194985
178fat-soluble vitamin metabolic process (GO:0006775)2.58061903
179detection of other organism (GO:0098543)2.57078892
180proline metabolic process (GO:0006560)2.56729688
181arachidonic acid metabolic process (GO:0019369)2.56635026
182vitamin biosynthetic process (GO:0009110)2.56536968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.15864475
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.16336434
3* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.30768491
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.28526835
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21567828
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06698640
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98225626
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94783589
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70092782
10* CLOCK_20551151_ChIP-Seq_293T_Human2.66728939
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.59777571
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.44781541
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36824387
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.16439725
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06517145
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04479450
17* VDR_21846776_ChIP-Seq_THP-1_Human1.98999102
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.96260637
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90013848
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86659392
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86537448
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.85829966
23P68_20966046_ChIP-Seq_HELA_Human1.81888054
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80311123
25MYC_22102868_ChIP-Seq_BL_Human1.80047177
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.78347977
27TCF7_22412390_ChIP-Seq_EML_Mouse1.76233611
28MAF_26560356_Chip-Seq_TH1_Human1.74029391
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73770032
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73242288
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69576888
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68969479
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68822892
34* VDR_24763502_ChIP-Seq_THP-1_Human1.66934039
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66826715
36CTCF_27219007_Chip-Seq_Bcells_Human1.62890479
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61763108
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60821788
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60275850
40RUNX_20019798_ChIP-Seq_JUKART_Human1.59982191
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59329445
42MYB_26560356_Chip-Seq_TH2_Human1.59194748
43SA1_27219007_Chip-Seq_Bcells_Human1.56352429
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56228427
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.55709358
46* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55412384
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.54564375
48SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52381690
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.52045900
50* RUNX1_22412390_ChIP-Seq_EML_Mouse1.51187665
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50360349
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50066532
53* MYB_26560356_Chip-Seq_TH1_Human1.49474785
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48371795
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47970351
56UTX_26944678_Chip-Seq_JUKART_Human1.46585240
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46033737
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43575063
59* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43355323
60SMC4_20622854_ChIP-Seq_HELA_Human1.43114331
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41955158
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41845097
63KDM2B_26808549_Chip-Seq_DND41_Human1.40260337
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40195743
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39795073
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38788136
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37544672
68CREB1_26743006_Chip-Seq_LNCaP_Human1.37535935
69LXR_22292898_ChIP-Seq_THP-1_Human1.37481769
70RACK7_27058665_Chip-Seq_MCF-7_Human1.35833144
71SCL_19346495_ChIP-Seq_HPC-7_Human1.35052796
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34094359
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.33066407
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.32145519
75* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31986631
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31633002
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31333839
78ATF3_27146783_Chip-Seq_COLON_Human1.30964510
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30052974
80GATA1_22025678_ChIP-Seq_K562_Human1.29536092
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29090266
82* E2F1_20622854_ChIP-Seq_HELA_Human1.28914515
83KDM2B_26808549_Chip-Seq_K562_Human1.28771771
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.27650731
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27611216
86* PHF8_20622854_ChIP-Seq_HELA_Human1.27068903
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25073163
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24450222
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23017176
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22749454
91GATA2_19941826_ChIP-Seq_K562_Human1.22718850
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22198667
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20289304
94ZNF263_19887448_ChIP-Seq_K562_Human1.19694284
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.19267831
96* GATA4_25053715_ChIP-Seq_YYC3_Human1.18306997
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17746650
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16905444
99MAF_26560356_Chip-Seq_TH2_Human1.16794346
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15839511
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15146578
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13885130
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.13692471
104TP63_22573176_ChIP-Seq_HFKS_Human1.13351967
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.13349713
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12990024
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.12584331
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11712796
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10534886
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10225551
111* RARA_24833708_ChIP-Seq_LIVER_Mouse1.09569516
112VDR_24787735_ChIP-Seq_THP-1_Human1.09429208
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09290833
114GATA6_25053715_ChIP-Seq_YYC3_Human1.08922061
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08903217
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08851197
117* ETS1_21867929_ChIP-Seq_TH2_Mouse1.08796327
118* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08145859
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.07492477
120CTCF_26484167_Chip-Seq_Bcells_Mouse1.07126081
121CTCF_20526341_ChIP-Seq_ESCs_Human1.06967678
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06829741
123* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04406188
124* BCL6_27268052_Chip-Seq_Bcells_Human1.02677386
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02168107
126* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01829882
127GATA1_19941826_ChIP-Seq_K562_Human1.01823671
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00387791
129* BCOR_27268052_Chip-Seq_Bcells_Human1.00300462
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00238030
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00015238
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.99915614
133* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99515625
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99388803
135PU_27001747_Chip-Seq_BMDM_Mouse0.98083627
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95768028
137NCOR1_26117541_ChIP-Seq_K562_Human0.95068859
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.93576497
139TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92136094
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90886726
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90564758
142SPI1_23547873_ChIP-Seq_NB4_Human0.89770395
143* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89591975
144SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88515400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.91636285
2MP0005670_abnormal_white_adipose3.64851144
3MP0009379_abnormal_foot_pigmentation3.55918650
4MP0010329_abnormal_lipoprotein_level2.90944352
5MP0001666_abnormal_nutrient_absorption2.62002907
6MP0005666_abnormal_adipose_tissue2.58001223
7MP0003724_increased_susceptibility_to2.56935418
8MP0005409_darkened_coat_color2.56306835
9MP0009840_abnormal_foam_cell2.48565064
10MP0004264_abnormal_extraembryonic_tissu2.38827988
11MP0010155_abnormal_intestine_physiology2.16478072
12MP0000685_abnormal_immune_system2.14823198
13MP0010234_abnormal_vibrissa_follicle2.13729758
14MP0004185_abnormal_adipocyte_glucose2.12745502
15MP0002139_abnormal_hepatobiliary_system2.12489290
16MP0005451_abnormal_body_composition2.06919255
17MP0009785_altered_susceptibility_to2.06127323
18MP0003191_abnormal_cellular_cholesterol2.04745203
19MP0005365_abnormal_bile_salt2.02219889
20MP0003436_decreased_susceptibility_to2.00855073
21MP0004130_abnormal_muscle_cell1.98497008
22MP0009278_abnormal_bone_marrow1.98262892
23MP0001873_stomach_inflammation1.95942193
24MP0003866_abnormal_defecation1.94456331
25MP0002971_abnormal_brown_adipose1.93253511
26MP0000678_abnormal_parathyroid_gland1.83078483
27MP0005058_abnormal_lysosome_morphology1.82308872
28MP0004858_abnormal_nervous_system1.81552216
29MP0009115_abnormal_fat_cell1.81308983
30MP0004147_increased_porphyrin_level1.79026925
31* MP0000609_abnormal_liver_physiology1.77796150
32MP0005375_adipose_tissue_phenotype1.74506699
33MP0003879_abnormal_hair_cell1.71403575
34MP0005332_abnormal_amino_acid1.69258223
35MP0009643_abnormal_urine_homeostasis1.68570067
36MP0002405_respiratory_system_inflammati1.68203520
37MP0005397_hematopoietic_system_phenotyp1.65216893
38MP0001545_abnormal_hematopoietic_system1.65216893
39MP0001790_abnormal_immune_system1.61261900
40MP0005387_immune_system_phenotype1.61261900
41MP0005166_decreased_susceptibility_to1.59481202
42MP0003252_abnormal_bile_duct1.57045067
43* MP0002118_abnormal_lipid_homeostasis1.54750149
44MP0003300_gastrointestinal_ulcer1.54606683
45MP0005334_abnormal_fat_pad1.54550986
46MP0004947_skin_inflammation1.53628193
47MP0000490_abnormal_crypts_of1.52066908
48MP0001800_abnormal_humoral_immune1.50157425
49MP0005076_abnormal_cell_differentiation1.44259854
50MP0003183_abnormal_peptide_metabolism1.41629724
51MP0005000_abnormal_immune_tolerance1.41077645
52MP0005085_abnormal_gallbladder_physiolo1.41052724
53MP0002419_abnormal_innate_immunity1.41006302
54MP0001188_hyperpigmentation1.40609179
55MP0005671_abnormal_response_to1.40541305
56MP0002166_altered_tumor_susceptibility1.35626174
57MP0001765_abnormal_ion_homeostasis1.34650056
58MP0005025_abnormal_response_to1.33939136
59MP0001845_abnormal_inflammatory_respons1.33714422
60* MP0001664_abnormal_digestion1.33687283
61MP0010352_gastrointestinal_tract_polyps1.33423742
62MP0002723_abnormal_immune_serum1.33333768
63MP0003705_abnormal_hypodermis_morpholog1.30617325
64MP0001533_abnormal_skeleton_physiology1.30197098
65MP0008961_abnormal_basal_metabolism1.29714493
66MP0008260_abnormal_autophagy1.29313860
67MP0002452_abnormal_antigen_presenting1.28943659
68MP0001819_abnormal_immune_cell1.28857499
69MP0002277_abnormal_respiratory_mucosa1.28227478
70MP0002420_abnormal_adaptive_immunity1.28183090
71MP0001853_heart_inflammation1.27832537
72MP0003806_abnormal_nucleotide_metabolis1.27208916
73MP0003763_abnormal_thymus_physiology1.25849532
74MP0000538_abnormal_urinary_bladder1.25105775
75* MP0005448_abnormal_energy_balance1.24318649
76MP0000343_altered_response_to1.22848612
77MP0000858_altered_metastatic_potential1.22125510
78MP0001835_abnormal_antigen_presentation1.20718323
79MP0008875_abnormal_xenobiotic_pharmacok1.19025226
80MP0003453_abnormal_keratinocyte_physiol1.16791122
81MP0002060_abnormal_skin_morphology1.15710888
82MP0002970_abnormal_white_adipose1.15697630
83MP0002138_abnormal_hepatobiliary_system1.15493665
84MP0003868_abnormal_feces_composition1.14351888
85MP0002136_abnormal_kidney_physiology1.13816875
86MP0003828_pulmonary_edema1.12204900
87MP0000477_abnormal_intestine_morphology1.09893636
88MP0005174_abnormal_tail_pigmentation1.09023733
89MP0002254_reproductive_system_inflammat1.08322071
90MP0003303_peritoneal_inflammation1.07996793
91MP0005381_digestive/alimentary_phenotyp1.06346106
92MP0005319_abnormal_enzyme/_coenzyme1.05969547
93MP0006082_CNS_inflammation1.05645352
94MP0005636_abnormal_mineral_homeostasis1.05156833
95MP0002933_joint_inflammation1.03702694
96MP0000003_abnormal_adipose_tissue1.01523175
97MP0000604_amyloidosis1.01140414
98MP0001849_ear_inflammation0.99690112
99MP0001663_abnormal_digestive_system0.99517587
100MP0003638_abnormal_response/metabolism_0.99212581
101MP0003448_altered_tumor_morphology0.98764756
102* MP0001881_abnormal_mammary_gland0.98039658
103MP0000716_abnormal_immune_system0.97343354
104MP0001764_abnormal_homeostasis0.96802735
105MP0009333_abnormal_splenocyte_physiolog0.96677737
106MP0001756_abnormal_urination0.96417072
107MP0008469_abnormal_protein_level0.96201237
108MP0005464_abnormal_platelet_physiology0.95459340
109MP0002006_tumorigenesis0.95020418
110MP0003329_amyloid_beta_deposits0.94922877
111MP0002398_abnormal_bone_marrow0.94409047
112MP0005584_abnormal_enzyme/coenzyme_acti0.90959459
113MP0003172_abnormal_lysosome_physiology0.90811928
114MP0000249_abnormal_blood_vessel0.89852018
115MP0004782_abnormal_surfactant_physiolog0.89437891
116MP0002796_impaired_skin_barrier0.88883326
117MP0003045_fibrosis0.88868992
118MP0002148_abnormal_hypersensitivity_rea0.87196281
119* MP0004019_abnormal_vitamin_homeostasis0.86660185
120MP0002998_abnormal_bone_remodeling0.85765953
121MP0002722_abnormal_immune_system0.85162436
122MP0000689_abnormal_spleen_morphology0.83691298
123MP0005535_abnormal_body_temperature0.83125559
124MP0003566_abnormal_cell_adhesion0.82863818
125MP0002876_abnormal_thyroid_physiology0.82314792
126MP0003075_altered_response_to0.82202350
127MP0002429_abnormal_blood_cell0.81892532
128MP0001986_abnormal_taste_sensitivity0.81477755
129MP0009763_increased_sensitivity_to0.79973436
130MP0004510_myositis0.79025880
131MP0008004_abnormal_stomach_pH0.78985968
132MP0009764_decreased_sensitivity_to0.77112349
133MP0000015_abnormal_ear_pigmentation0.76425566
134MP0004043_abnormal_pH_regulation0.74991163
135* MP0009642_abnormal_blood_homeostasis0.74715348
136MP0002822_catalepsy0.72712820

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.75385521
2Retrobulbar optic neuritis (HP:0100654)5.53178498
3Optic neuritis (HP:0100653)5.53178498
4Myositis (HP:0100614)5.43613311
5Systemic lupus erythematosus (HP:0002725)4.85364540
6Hydroxyprolinuria (HP:0003080)4.67668683
7Abnormality of proline metabolism (HP:0010907)4.67668683
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32775779
9Keratoconjunctivitis sicca (HP:0001097)4.27997274
10Increased density of long bones (HP:0006392)4.26426399
11Thin bony cortex (HP:0002753)4.09988184
12Widely patent fontanelles and sutures (HP:0004492)4.03395466
13Hyperglycinuria (HP:0003108)3.91381531
14Autoimmune thrombocytopenia (HP:0001973)3.86957462
15Keratoconjunctivitis (HP:0001096)3.80332486
16Hypertriglyceridemia (HP:0002155)3.61475951
17Hemorrhage of the eye (HP:0011885)3.58607045
18Confusion (HP:0001289)3.52336025
19Ileus (HP:0002595)3.39030234
20Abnormality of the vitamin B12 metabolism (HP:0004341)3.34555587
21Pancreatitis (HP:0001733)3.27220408
22Oligomenorrhea (HP:0000876)3.24943478
23Pigmentary retinal degeneration (HP:0001146)3.20206225
24Persistence of primary teeth (HP:0006335)3.19011376
25Fat malabsorption (HP:0002630)3.14450298
26Hypobetalipoproteinemia (HP:0003563)3.10374718
27B lymphocytopenia (HP:0010976)3.09595983
28Abnormality of B cell number (HP:0010975)3.09595983
29Abnormality of vitamin B metabolism (HP:0004340)3.07699165
30Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07406380
31Pustule (HP:0200039)3.06875864
32IgM deficiency (HP:0002850)3.03171120
33Eczematoid dermatitis (HP:0000976)3.01547132
34Severe combined immunodeficiency (HP:0004430)3.00594493
35Increased IgE level (HP:0003212)2.99550127
36Hypophosphatemia (HP:0002148)2.99504573
37Decreased circulating renin level (HP:0003351)2.96792918
38Growth hormone excess (HP:0000845)2.94171576
39Wide cranial sutures (HP:0010537)2.92337484
40Combined immunodeficiency (HP:0005387)2.90772112
41Acanthosis nigricans (HP:0000956)2.88756706
42Arterial thrombosis (HP:0004420)2.81720648
43Abnormality of serine family amino acid metabolism (HP:0010894)2.81139271
44Abnormality of glycine metabolism (HP:0010895)2.81139271
45Abnormality of complement system (HP:0005339)2.79756366
46Hypolipoproteinemia (HP:0010981)2.76289481
47Complement deficiency (HP:0004431)2.70496498
48Acanthocytosis (HP:0001927)2.69849720
49Polycythemia (HP:0001901)2.68880091
50Cupped ribs (HP:0000887)2.66498516
51Abdominal distention (HP:0003270)2.65772015
52Recurrent fungal infections (HP:0002841)2.61436098
53Abnormality of vitamin metabolism (HP:0100508)2.61128655
54Glomerulonephritis (HP:0000099)2.60470801
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60357663
56Myocardial infarction (HP:0001658)2.57608698
57Thyroiditis (HP:0100646)2.56920025
58IgA deficiency (HP:0002720)2.56325548
59Anorexia (HP:0002039)2.55799016
60Hyperparathyroidism (HP:0000843)2.55593813
61Pulmonary infiltrates (HP:0002113)2.53841780
62Delayed epiphyseal ossification (HP:0002663)2.52809020
63Abnormality of fatty-acid metabolism (HP:0004359)2.52803659
64Glycosuria (HP:0003076)2.48622556
65Abnormality of urine glucose concentration (HP:0011016)2.48622556
66Xanthomatosis (HP:0000991)2.48155454
67Abnormality of macrophages (HP:0004311)2.47835831
68Encephalitis (HP:0002383)2.45730312
69Hemoptysis (HP:0002105)2.44959068
70Nephrolithiasis (HP:0000787)2.43939046
71Abnormality of the nasal mucosa (HP:0000433)2.43495813
72Abnormal platelet volume (HP:0011876)2.42216226
73Nausea (HP:0002018)2.41973436
74Myoglobinuria (HP:0002913)2.40679249
75Alopecia of scalp (HP:0002293)2.38577072
76Chronic diarrhea (HP:0002028)2.38290171
77Nasal polyposis (HP:0100582)2.37548103
78Increased mean platelet volume (HP:0011877)2.37064507
79Amyloidosis (HP:0011034)2.36968985
80Premature loss of primary teeth (HP:0006323)2.36077228
81Alkalosis (HP:0001948)2.35851137
82Abnormality of the costochondral junction (HP:0000919)2.35622121
83Congenital sensorineural hearing impairment (HP:0008527)2.35253374
84Hyperammonemia (HP:0001987)2.33316410
85Myopathic facies (HP:0002058)2.32637119
86Villous atrophy (HP:0011473)2.31501019
87Abnormality of small intestinal villus morphology (HP:0011472)2.31501019
88Malnutrition (HP:0004395)2.29859845
89Hypoalphalipoproteinemia (HP:0003233)2.28215721
90Facial shape deformation (HP:0011334)2.27314843
91Potter facies (HP:0002009)2.27314843
92Insulin resistance (HP:0000855)2.24552391
93Hypercholesterolemia (HP:0003124)2.23723787
94Enlarged epiphyses (HP:0010580)2.22446060
95Vasculitis (HP:0002633)2.22350197
96Hyperuricemia (HP:0002149)2.21188185
97Increased purine levels (HP:0004368)2.21188185
98Bone cyst (HP:0012062)2.19021092
99Gastrointestinal infarctions (HP:0005244)2.18635611
100Epidermoid cyst (HP:0200040)2.18446412
101Rhabdomyolysis (HP:0003201)2.18166214
102Polygenic inheritance (HP:0010982)2.16825794
103Metabolic alkalosis (HP:0200114)2.16355277
104Petechiae (HP:0000967)2.15434400
105Pulmonary embolism (HP:0002204)2.14985701
106Abnormal urine phosphate concentration (HP:0012599)2.14287020
107Right ventricular cardiomyopathy (HP:0011663)2.13438617
108Hypoglycemic coma (HP:0001325)2.12167254
109Nephritis (HP:0000123)2.10582111
110Insulin-resistant diabetes mellitus (HP:0000831)2.09415276
111Abnormality of renin-angiotensin system (HP:0000847)2.07669536
112Steatorrhea (HP:0002570)2.07137637
113Abnormal enzyme/coenzyme activity (HP:0012379)2.06829199
114Gingivitis (HP:0000230)2.06745919
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06524738
116Glomerulopathy (HP:0100820)2.05470214
117Abnormality of alkaline phosphatase activity (HP:0004379)2.05188644
118Autoimmune hemolytic anemia (HP:0001890)2.02264816
119Abnormality of T cell physiology (HP:0011840)2.02134422
120Hepatosplenomegaly (HP:0001433)2.01738534
121Cheilitis (HP:0100825)2.01660143
122Abnormality of pyrimidine metabolism (HP:0004353)2.01265497
123Elevated erythrocyte sedimentation rate (HP:0003565)1.99888321
124Proximal tubulopathy (HP:0000114)1.99827960
125Megaloblastic anemia (HP:0001889)1.99614338
126Dysostosis multiplex (HP:0000943)1.98573548
127Hyperactive renin-angiotensin system (HP:0000841)1.98146588
128Generalized aminoaciduria (HP:0002909)1.95278409
129Gastrointestinal dysmotility (HP:0002579)1.94779842
130Protuberant abdomen (HP:0001538)1.94303431
131Focal segmental glomerulosclerosis (HP:0000097)1.93428488
132Ketoacidosis (HP:0001993)1.93418450
133Hypotension (HP:0002615)1.93074557
134Chronic obstructive pulmonary disease (HP:0006510)1.92937705
135Obstructive lung disease (HP:0006536)1.92937705
136Abnormality of nucleobase metabolism (HP:0010932)1.92789256
137Cerebral palsy (HP:0100021)1.92569780
138Inflammation of the large intestine (HP:0002037)1.92386121
139Stomatitis (HP:0010280)1.91545424
140Segmental peripheral demyelination/remyelination (HP:0003481)1.90998653
141Abnormality of eosinophils (HP:0001879)1.90876156
142Flat acetabular roof (HP:0003180)1.90864521
143Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90662686
144Dicarboxylic aciduria (HP:0003215)1.90662686
145Abnormality of T cells (HP:0002843)1.90312428
146Recurrent abscess formation (HP:0002722)1.89762125
147Gangrene (HP:0100758)1.89041973
148Abnormality of purine metabolism (HP:0004352)1.88904312
149Emphysema (HP:0002097)1.87668031
150Rectal prolapse (HP:0002035)1.87248657
151Colitis (HP:0002583)1.87109296
152Bone pain (HP:0002653)1.86052627
153Long foot (HP:0001833)1.85692974
154Recurrent gram-negative bacterial infections (HP:0005420)1.84230282
155Elevated alkaline phosphatase (HP:0003155)1.83032671
156Polyneuropathy (HP:0001271)1.83032465
157Gastrointestinal inflammation (HP:0004386)1.82862519
158Axonal loss (HP:0003447)1.82309967
159Recurrent bacterial skin infections (HP:0005406)1.80876463
160Spontaneous hematomas (HP:0007420)1.80843343
161Subcapsular cataract (HP:0000523)1.79156337
162Multiple lipomas (HP:0001012)1.78670976
163T lymphocytopenia (HP:0005403)1.78654131
164Mesangial abnormality (HP:0001966)1.77701316
165Abnormal platelet function (HP:0011869)1.77039417
166Impaired platelet aggregation (HP:0003540)1.77039417
167Gastrointestinal stroma tumor (HP:0100723)1.76906399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.73672668
2TAOK34.02379882
3ACVR1B3.69953396
4TXK3.39886964
5TRIB32.92354886
6ERN12.76716636
7RIPK42.54021116
8EPHA22.39793231
9MAPK152.28134652
10MST1R2.16470980
11PRPF4B2.15276021
12SIK12.12246688
13MAP4K12.11265720
14GRK62.11194314
15CAMK1D2.07855941
16TESK22.03193252
17JAK11.94926456
18EPHB11.87111147
19RIPK11.84629168
20LMTK21.78813215
21FRK1.70207829
22PIM11.59559180
23TBK11.59556145
24TEC1.55937305
25BMX1.55889050
26PDK41.54393796
27PDK31.54393796
28MAP3K101.53463928
29CSK1.50510624
30ITK1.48150832
31MAP3K61.46500924
32MAP3K11.45942980
33EPHB21.39468109
34ICK1.39383258
35MAP3K141.38625582
36STK101.38556134
37MATK1.34314805
38MAP3K111.33428181
39CDK91.31978785
40BCKDK1.29576929
41MAP2K21.29208677
42DDR21.24556429
43SMG11.23850095
44CDC42BPA1.23671107
45PTK61.20919823
46CDK61.18106959
47JAK31.17771819
48PRKG21.16952791
49MAP2K31.16252550
50ZAP701.15795544
51CAMK1G1.15449075
52FGFR41.14750498
53TYK21.14688779
54BTK1.13059058
55IKBKB1.03994686
56GSK3A1.01650281
57TGFBR21.01642451
58FGFR31.01388176
59KSR21.00121328
60PRKAA20.97558238
61PDK20.96626715
62CHUK0.93590541
63MAPK110.92407035
64TESK10.91932211
65EPHA30.89956457
66FGR0.88585342
67MET0.86067754
68PKN20.81354941
69EEF2K0.79719078
70MAP2K60.79081338
71JAK20.78376931
72IKBKE0.77368485
73PIM20.74572437
74CDK40.74341363
75MAP3K30.73911064
76TNK20.73813387
77CDK120.73299134
78STK240.71600391
79TAOK10.71596874
80RPS6KA20.71348039
81MAPK120.70893867
82MST40.69845617
83TRPM70.69511177
84RPS6KB10.67780122
85RPS6KA10.64687767
86RPS6KC10.62108676
87RPS6KL10.62108676
88TAOK20.60608286
89HCK0.60404249
90NME20.57705481
91ABL20.57559630
92PTK20.56947382
93MAPKAPK20.56579591
94MAP3K130.56328549
95BLK0.55821131
96ERBB20.54684985
97MARK20.53968617
98IRAK40.53960740
99MAPK40.53785524
100RET0.53405399
101PDK10.50183231
102LCK0.49817619
103DYRK1B0.49255037
104PRKAA10.49124898
105PDGFRB0.49070767
106PIK3CA0.48979024
107PDPK10.47686959
108MAP3K20.47314357
109NLK0.46847866
110MAPKAPK30.46804556
111CSF1R0.46072259
112TYRO30.45210918
113HIPK20.44984701
114PRKACG0.43428289
115PRKCZ0.43250506
116PAK40.43018486
117LYN0.42782862
118FES0.42777274
119PDGFRA0.41382417
120MAP3K70.41246254
121MARK30.40762798
122IRAK20.40153400
123NEK90.40117948
124SIK20.38498039
125SYK0.37983951
126MAPK70.37711541
127TLK10.37370358
128MTOR0.37103311
129AKT30.36998288
130RPS6KA40.36947038
131FYN0.36862716
132BRAF0.36581729
133RPS6KA60.36496219
134KIT0.36298175
135TSSK60.34177741
136IGF1R0.34113637
137NME10.33816905
138PRKD20.33344234
139LRRK20.30291359
140INSR0.29908362

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.73623125
2* Fat digestion and absorption_Homo sapiens_hsa049753.81206598
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.65499124
4Fatty acid biosynthesis_Homo sapiens_hsa000613.29615076
5PPAR signaling pathway_Homo sapiens_hsa033202.93292096
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82921745
7Caffeine metabolism_Homo sapiens_hsa002322.72172375
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32588030
9Renin-angiotensin system_Homo sapiens_hsa046142.28882487
10Fatty acid metabolism_Homo sapiens_hsa012122.14559346
11Propanoate metabolism_Homo sapiens_hsa006402.11632671
12Fatty acid degradation_Homo sapiens_hsa000712.11358989
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09684994
14Vitamin digestion and absorption_Homo sapiens_hsa049771.97746141
15* Glycerolipid metabolism_Homo sapiens_hsa005611.90196073
16Other glycan degradation_Homo sapiens_hsa005111.86702747
17Galactose metabolism_Homo sapiens_hsa000521.84727168
18Starch and sucrose metabolism_Homo sapiens_hsa005001.77985866
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74542628
20Fructose and mannose metabolism_Homo sapiens_hsa000511.62672610
21Circadian rhythm_Homo sapiens_hsa047101.62498992
22Mineral absorption_Homo sapiens_hsa049781.57255752
23Osteoclast differentiation_Homo sapiens_hsa043801.53556907
24Chemical carcinogenesis_Homo sapiens_hsa052041.47369023
25Carbon metabolism_Homo sapiens_hsa012001.41323084
26Linoleic acid metabolism_Homo sapiens_hsa005911.40420188
27Pyruvate metabolism_Homo sapiens_hsa006201.35872923
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.30988612
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30036079
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29508365
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.26937751
32Arachidonic acid metabolism_Homo sapiens_hsa005901.23983265
33Pentose phosphate pathway_Homo sapiens_hsa000301.22371454
34Legionellosis_Homo sapiens_hsa051341.22006465
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19767037
36Glutathione metabolism_Homo sapiens_hsa004801.19524701
37Asthma_Homo sapiens_hsa053101.17014780
38beta-Alanine metabolism_Homo sapiens_hsa004101.15085660
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14846910
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.14174838
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.13473294
42Phenylalanine metabolism_Homo sapiens_hsa003601.13107047
43Folate biosynthesis_Homo sapiens_hsa007901.12031988
44Leishmaniasis_Homo sapiens_hsa051401.11568088
45TNF signaling pathway_Homo sapiens_hsa046681.08557723
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08143603
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07663727
48Allograft rejection_Homo sapiens_hsa053301.04941407
49Primary immunodeficiency_Homo sapiens_hsa053401.01528845
50* Retinol metabolism_Homo sapiens_hsa008301.00844438
51Sulfur metabolism_Homo sapiens_hsa009200.99383048
52Tryptophan metabolism_Homo sapiens_hsa003800.98007365
53Insulin resistance_Homo sapiens_hsa049310.97834652
54Lysine degradation_Homo sapiens_hsa003100.97710287
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.97431630
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97277990
57Staphylococcus aureus infection_Homo sapiens_hsa051500.95326171
58Autoimmune thyroid disease_Homo sapiens_hsa053200.92327112
59Graft-versus-host disease_Homo sapiens_hsa053320.90489751
60Arginine biosynthesis_Homo sapiens_hsa002200.90430690
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89965575
62Protein digestion and absorption_Homo sapiens_hsa049740.87779344
63Nitrogen metabolism_Homo sapiens_hsa009100.87376080
64AMPK signaling pathway_Homo sapiens_hsa041520.84315034
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84283886
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82663890
67Arginine and proline metabolism_Homo sapiens_hsa003300.82328013
68Measles_Homo sapiens_hsa051620.79599634
69Acute myeloid leukemia_Homo sapiens_hsa052210.78519323
70Toxoplasmosis_Homo sapiens_hsa051450.75538146
71ABC transporters_Homo sapiens_hsa020100.73178296
72Peroxisome_Homo sapiens_hsa041460.73117003
73Biosynthesis of amino acids_Homo sapiens_hsa012300.69476760
74T cell receptor signaling pathway_Homo sapiens_hsa046600.69241438
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69130869
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68992981
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67645207
78Insulin signaling pathway_Homo sapiens_hsa049100.66468675
79Sphingolipid metabolism_Homo sapiens_hsa006000.65072629
80Histidine metabolism_Homo sapiens_hsa003400.64604653
81Sulfur relay system_Homo sapiens_hsa041220.63261440
82Bile secretion_Homo sapiens_hsa049760.63022906
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.62128222
84Apoptosis_Homo sapiens_hsa042100.61768229
85Pertussis_Homo sapiens_hsa051330.59530548
86Ether lipid metabolism_Homo sapiens_hsa005650.59492081
87Type I diabetes mellitus_Homo sapiens_hsa049400.58328295
88B cell receptor signaling pathway_Homo sapiens_hsa046620.57968242
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57661981
90Shigellosis_Homo sapiens_hsa051310.55605552
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.52510059
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.52380033
93Prolactin signaling pathway_Homo sapiens_hsa049170.51877685
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51385972
95Type II diabetes mellitus_Homo sapiens_hsa049300.51276884
96Complement and coagulation cascades_Homo sapiens_hsa046100.50247794
97Hematopoietic cell lineage_Homo sapiens_hsa046400.47548029
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47354563
99Tyrosine metabolism_Homo sapiens_hsa003500.47144599
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.47114650
101Influenza A_Homo sapiens_hsa051640.46875994
102Pancreatic secretion_Homo sapiens_hsa049720.45778332
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.45569156
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44489200
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43050175
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.42975126
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42822571
108VEGF signaling pathway_Homo sapiens_hsa043700.42120339
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41796667
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41612067
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41573759
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40212514
113Salmonella infection_Homo sapiens_hsa051320.38125073
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38054820
115Chemokine signaling pathway_Homo sapiens_hsa040620.36922242
116Hepatitis B_Homo sapiens_hsa051610.36609999
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36532670
118African trypanosomiasis_Homo sapiens_hsa051430.35973087
119HIF-1 signaling pathway_Homo sapiens_hsa040660.35355045
120Hepatitis C_Homo sapiens_hsa051600.35134476
121Chronic myeloid leukemia_Homo sapiens_hsa052200.32728140
122GnRH signaling pathway_Homo sapiens_hsa049120.32154226
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31316569
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31054178
125Herpes simplex infection_Homo sapiens_hsa051680.30230622
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29242864
127Antigen processing and presentation_Homo sapiens_hsa046120.29073906
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28819507
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28384599
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27822868
131Lysosome_Homo sapiens_hsa041420.27076799
132Renin secretion_Homo sapiens_hsa049240.26972614
133Notch signaling pathway_Homo sapiens_hsa043300.25585103
134Tuberculosis_Homo sapiens_hsa051520.25082306
135Glucagon signaling pathway_Homo sapiens_hsa049220.22598292
136Viral myocarditis_Homo sapiens_hsa054160.21806688
137Thyroid hormone synthesis_Homo sapiens_hsa049180.21439844

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