DGAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.03274763
2L-phenylalanine catabolic process (GO:0006559)6.03274763
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75971168
4L-phenylalanine metabolic process (GO:0006558)5.75971168
5alpha-linolenic acid metabolic process (GO:0036109)5.60002178
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.56383256
7aromatic amino acid family catabolic process (GO:0009074)5.10200935
8regulation of triglyceride catabolic process (GO:0010896)5.09500117
9* triglyceride biosynthetic process (GO:0019432)4.93730049
10brown fat cell differentiation (GO:0050873)4.91545329
11complement activation, alternative pathway (GO:0006957)4.87703453
12sulfur amino acid catabolic process (GO:0000098)4.85291595
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83187382
14regulation of sequestering of triglyceride (GO:0010889)4.82966766
15* acylglycerol biosynthetic process (GO:0046463)4.73857454
16* neutral lipid biosynthetic process (GO:0046460)4.73857454
17fatty acid beta-oxidation (GO:0006635)4.69473532
18positive regulation of fatty acid beta-oxidation (GO:0032000)4.68226658
19urea metabolic process (GO:0019627)4.58753330
20urea cycle (GO:0000050)4.58753330
21valine metabolic process (GO:0006573)4.57418695
22fatty acid transmembrane transport (GO:1902001)4.57122041
23acetyl-CoA metabolic process (GO:0006084)4.56347394
24triglyceride catabolic process (GO:0019433)4.56230919
25bile acid biosynthetic process (GO:0006699)4.55643573
26biotin metabolic process (GO:0006768)4.53394308
27glyoxylate metabolic process (GO:0046487)4.50708717
28neutral lipid catabolic process (GO:0046461)4.44951756
29acylglycerol catabolic process (GO:0046464)4.44951756
30lysine catabolic process (GO:0006554)4.42609663
31lysine metabolic process (GO:0006553)4.42609663
32cysteine metabolic process (GO:0006534)4.41278005
33fatty acid oxidation (GO:0019395)4.41273905
34* fatty acid homeostasis (GO:0055089)4.39200488
35positive regulation of lipid catabolic process (GO:0050996)4.36630088
36kynurenine metabolic process (GO:0070189)4.34943211
37* plasma lipoprotein particle clearance (GO:0034381)4.33649909
38lipid oxidation (GO:0034440)4.32695774
39fatty acid catabolic process (GO:0009062)4.32487131
40amino-acid betaine metabolic process (GO:0006577)4.31423769
41indole-containing compound catabolic process (GO:0042436)4.29828839
42indolalkylamine catabolic process (GO:0046218)4.29828839
43tryptophan catabolic process (GO:0006569)4.29828839
44CDP-diacylglycerol biosynthetic process (GO:0016024)4.27370760
45nitrogen cycle metabolic process (GO:0071941)4.24939905
46high-density lipoprotein particle remodeling (GO:0034375)4.24758969
47positive regulation of fatty acid oxidation (GO:0046321)4.24341439
48* triglyceride homeostasis (GO:0070328)4.21115667
49* acylglycerol homeostasis (GO:0055090)4.21115667
50positive regulation of cholesterol efflux (GO:0010875)4.19786774
51* lipid storage (GO:0019915)4.19217311
52regulation of protein activation cascade (GO:2000257)4.18919351
53ethanol metabolic process (GO:0006067)4.13127192
54white fat cell differentiation (GO:0050872)4.13075998
55CDP-diacylglycerol metabolic process (GO:0046341)4.12689927
56positive regulation of lipid storage (GO:0010884)4.12614722
57carnitine shuttle (GO:0006853)4.12152723
58negative regulation of fibrinolysis (GO:0051918)4.11755564
59NADH metabolic process (GO:0006734)4.11573965
60linoleic acid metabolic process (GO:0043651)4.11348648
61* neutral lipid metabolic process (GO:0006638)4.07893165
62bile acid metabolic process (GO:0008206)4.07762530
63short-chain fatty acid metabolic process (GO:0046459)4.07223770
64serine family amino acid catabolic process (GO:0009071)4.05430931
65protein carboxylation (GO:0018214)4.04524230
66peptidyl-glutamic acid carboxylation (GO:0017187)4.04524230
67tryptophan metabolic process (GO:0006568)4.04020312
68monocarboxylic acid catabolic process (GO:0072329)4.01659109
69regulation of complement activation (GO:0030449)3.98067585
702-oxoglutarate metabolic process (GO:0006103)3.95411754
71negative regulation of phagocytosis (GO:0050765)3.94585196
72cellular ketone body metabolic process (GO:0046950)3.91717938
73regulation of fibrinolysis (GO:0051917)3.90188637
74* low-density lipoprotein particle clearance (GO:0034383)3.89801910
75reverse cholesterol transport (GO:0043691)3.89758937
76plasma lipoprotein particle remodeling (GO:0034369)3.89284796
77protein-lipid complex remodeling (GO:0034368)3.89284796
78macromolecular complex remodeling (GO:0034367)3.89284796
79branched-chain amino acid catabolic process (GO:0009083)3.89154919
80homocysteine metabolic process (GO:0050667)3.88742448
81alpha-amino acid catabolic process (GO:1901606)3.86963861
82tyrosine metabolic process (GO:0006570)3.84958663
83negative regulation of lipase activity (GO:0060192)3.83501990
84lipid particle organization (GO:0034389)3.81448046
85* diacylglycerol metabolic process (GO:0046339)3.80934560
86phospholipid homeostasis (GO:0055091)3.80261372
87* fatty-acyl-CoA metabolic process (GO:0035337)3.80094846
88regulation of cholesterol esterification (GO:0010872)3.79649336
89regulation of fatty acid beta-oxidation (GO:0031998)3.79168840
90phospholipid efflux (GO:0033700)3.78756272
91ethanol oxidation (GO:0006069)3.75793689
92negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.74708235
93branched-chain amino acid metabolic process (GO:0009081)3.73782794
94thioester biosynthetic process (GO:0035384)3.72434375
95acyl-CoA biosynthetic process (GO:0071616)3.72434375
96regulation of glycogen (starch) synthase activity (GO:2000465)3.71643622
97carnitine metabolic process (GO:0009437)3.70357775
98fatty-acyl-CoA biosynthetic process (GO:0046949)3.70119729
99negative regulation of granulocyte differentiation (GO:0030853)3.69615830
100cellular amino acid catabolic process (GO:0009063)3.69140356
101positive regulation of cholesterol transport (GO:0032376)3.67161215
102positive regulation of sterol transport (GO:0032373)3.67161215
103oxaloacetate metabolic process (GO:0006107)3.66395060
104* thioester metabolic process (GO:0035383)3.65892813
105* acyl-CoA metabolic process (GO:0006637)3.65892813
106aromatic amino acid family metabolic process (GO:0009072)3.65110005
107organic acid catabolic process (GO:0016054)3.64507868
108carboxylic acid catabolic process (GO:0046395)3.64507868
109negative regulation of protein autophosphorylation (GO:0031953)3.62220633
110tricarboxylic acid metabolic process (GO:0072350)3.60540987
111regulation of triglyceride metabolic process (GO:0090207)3.56865038
112regulation of fatty acid oxidation (GO:0046320)3.54951749
113response to phenylpropanoid (GO:0080184)3.53486897
114coenzyme catabolic process (GO:0009109)3.52733685
115positive regulation of triglyceride metabolic process (GO:0090208)3.51964848
116* triglyceride metabolic process (GO:0006641)3.51784803
117polyol transport (GO:0015791)3.51343718
118positive regulation of fatty acid metabolic process (GO:0045923)3.50387364
119positive regulation of triglyceride lipase activity (GO:0061365)3.49775988
120positive regulation of lipoprotein lipase activity (GO:0051006)3.49775988
121regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.49470500
122negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.41647945
123* long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.41002011
124negative regulation of lipid catabolic process (GO:0050995)3.39517975
125* primary alcohol metabolic process (GO:0034308)3.39227558
126regulation of cholesterol storage (GO:0010885)3.37392120
127aspartate family amino acid catabolic process (GO:0009068)3.36511174
128ketone body metabolic process (GO:1902224)3.36285077
129carnitine transmembrane transport (GO:1902603)3.36213573
130negative regulation of sterol transport (GO:0032372)3.35924370
131negative regulation of cholesterol transport (GO:0032375)3.35924370
132cellular response to epinephrine stimulus (GO:0071872)3.33173185
133* acylglycerol metabolic process (GO:0006639)3.32836308
134cholesterol efflux (GO:0033344)3.32791660
135long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.32152233
136regulation of cholesterol metabolic process (GO:0090181)3.30122841
137glycerolipid catabolic process (GO:0046503)3.29219130
138regulation of triglyceride biosynthetic process (GO:0010866)3.28983171
139regulation of macrophage derived foam cell differentiation (GO:0010743)3.23848298
140regulation of lipid catabolic process (GO:0050994)3.19154968
141response to dietary excess (GO:0002021)3.18540690
142regulation of lipid storage (GO:0010883)3.13904495
143phosphatidic acid metabolic process (GO:0046473)3.13327729
144phosphatidic acid biosynthetic process (GO:0006654)3.13327729
145very long-chain fatty acid metabolic process (GO:0000038)3.12577906
146regulation of sterol transport (GO:0032371)3.09991424
147regulation of cholesterol transport (GO:0032374)3.09991424
148fatty acid elongation (GO:0030497)2.95732376
149cellular response to lithium ion (GO:0071285)2.92445886
150regulation of cAMP-dependent protein kinase activity (GO:2000479)2.91312172
151negative regulation of lipid storage (GO:0010888)2.90292622
152positive regulation of glomerulus development (GO:0090193)2.89820519
153detection of molecule of bacterial origin (GO:0032490)2.86481980
154protein heterotrimerization (GO:0070208)2.85217713
155transcytosis (GO:0045056)2.85002717
156L-serine transport (GO:0015825)2.82150781
157positive regulation of glycolytic process (GO:0045821)2.82141641
158positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.79769686
159response to epinephrine (GO:0071871)2.75778643
160primary alcohol catabolic process (GO:0034310)2.75573252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.22262426
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.03713193
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.75898727
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.81243728
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.45262708
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.74797567
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.26898485
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.86179957
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64537677
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.55517221
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56704302
12* CLOCK_20551151_ChIP-Seq_293T_Human2.52473974
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.23081392
14* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72808660
15GATA1_22025678_ChIP-Seq_K562_Human1.51336700
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51110941
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50617038
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49002481
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48177391
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42727458
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42686839
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39544194
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33697339
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33409095
25VDR_24763502_ChIP-Seq_THP-1_Human1.32324285
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32139632
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.32023544
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31664990
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29994887
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29393016
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.28854694
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.28718111
33ZNF263_19887448_ChIP-Seq_K562_Human1.26671824
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24100245
35VDR_21846776_ChIP-Seq_THP-1_Human1.23529958
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.22142878
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19625248
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19037542
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17434424
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16307377
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16070946
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13881212
43RUNX_20019798_ChIP-Seq_JUKART_Human1.13196565
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12980299
45PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12800353
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08854010
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08062962
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07575339
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.07164067
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07085132
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06522331
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06356529
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06137742
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05966122
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.04111717
56HTT_18923047_ChIP-ChIP_STHdh_Human1.01485558
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00271140
58PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99425778
59* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99119005
60SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98364644
61VDR_24787735_ChIP-Seq_THP-1_Human0.97726734
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95551570
63P68_20966046_ChIP-Seq_HELA_Human0.94584612
64KDM2B_26808549_Chip-Seq_DND41_Human0.93908151
65GATA1_19941827_ChIP-Seq_MEL_Mouse0.93008879
66SCL_19346495_ChIP-Seq_HPC-7_Human0.92524168
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92228076
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91465350
69TRIM28_21343339_ChIP-Seq_HEK293_Human0.91356491
70TP63_17297297_ChIP-ChIP_HaCaT_Human0.90324242
71FOXO3_23340844_ChIP-Seq_DLD1_Human0.88904324
72ESR1_20079471_ChIP-ChIP_T-47D_Human0.88666916
73SMC4_20622854_ChIP-Seq_HELA_Human0.88594805
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88527006
75TCF7_22412390_ChIP-Seq_EML_Mouse0.88319795
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87528708
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87355876
78BCL6_27268052_Chip-Seq_Bcells_Human0.86314325
79RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85853851
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85646936
81* SPI1_23127762_ChIP-Seq_K562_Human0.85175893
82* TBX20_22328084_ChIP-Seq_HEART_Mouse0.84495671
83* TBX20_22080862_ChIP-Seq_HEART_Mouse0.84495671
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83182254
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83182254
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82617243
87GATA4_25053715_ChIP-Seq_YYC3_Human0.81425746
88MAF_26560356_Chip-Seq_TH1_Human0.81406324
89MAF_26560356_Chip-Seq_TH2_Human0.80861772
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80831425
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80595278
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80515374
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79024695
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78850229
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78798777
96KDM2B_26808549_Chip-Seq_K562_Human0.78162154
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78120360
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77683345
99SPI1_20517297_ChIP-Seq_HL60_Human0.77550586
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76675132
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76277131
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.75980420
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75889250
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75357919
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73858761
106LXR_22292898_ChIP-Seq_THP-1_Human0.72719051
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71501951
108GATA1_19941826_ChIP-Seq_K562_Human0.70519565
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69707716
110CEBPB_22108803_ChIP-Seq_LS180_Human0.69193471
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69021466
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.68616103
113* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67263776
114BCAT_22108803_ChIP-Seq_LS180_Human0.67084920
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66590801
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65122042
117GATA2_19941826_ChIP-Seq_K562_Human0.63915673
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63448683
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62088708
120* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61572532
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.60928799
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60465819
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60241827
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.57549854
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.56936324
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.55724690
127CBP_21632823_ChIP-Seq_H3396_Human0.55319447
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55142273
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.54643359
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.54444767
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54009442
132SOX2_20726797_ChIP-Seq_SW620_Human0.53953627
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.53860319
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53323374
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52341344
136MYC_19915707_ChIP-ChIP_AK7_Human0.51164885
137EGR1_19032775_ChIP-ChIP_M12_Human0.50317113
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50021276
139* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.49912338
140RACK7_27058665_Chip-Seq_MCF-7_Human0.49010864
141CTCF_27219007_Chip-Seq_Bcells_Human0.48941592
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48275660
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.47806514
144CSB_26484114_Chip-Seq_FIBROBLAST_Human0.47140466
145P53_21459846_ChIP-Seq_SAOS-2_Human0.47110984
146* GATA3_24758297_ChIP-Seq_MCF-7_Human0.46814048
147KLF4_19829295_ChIP-Seq_ESCs_Human0.46458172
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.46036247
149RXR_22108803_ChIP-Seq_LS180_Human0.45812593
150BCOR_27268052_Chip-Seq_Bcells_Human0.45430411
151CJUN_26792858_Chip-Seq_BT549_Human0.45315200
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.44714114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.57508187
2MP0005360_urolithiasis6.15443404
3MP0005365_abnormal_bile_salt5.07043074
4MP0005085_abnormal_gallbladder_physiolo4.80612504
5MP0005670_abnormal_white_adipose4.23296659
6MP0010329_abnormal_lipoprotein_level3.94187110
7MP0008875_abnormal_xenobiotic_pharmacok3.82884067
8MP0003806_abnormal_nucleotide_metabolis2.93712164
9MP0003191_abnormal_cellular_cholesterol2.91401495
10MP0003252_abnormal_bile_duct2.89253926
11MP0005666_abnormal_adipose_tissue2.89164032
12MP0004130_abnormal_muscle_cell2.86264557
13MP0009840_abnormal_foam_cell2.61994645
14MP0002837_dystrophic_cardiac_calcinosis2.58673826
15* MP0002118_abnormal_lipid_homeostasis2.50389020
16MP0005332_abnormal_amino_acid2.47682314
17MP0004185_abnormal_adipocyte_glucose2.29988368
18MP0003828_pulmonary_edema2.15653670
19MP0000609_abnormal_liver_physiology2.14838417
20MP0001666_abnormal_nutrient_absorption2.12561162
21MP0002971_abnormal_brown_adipose2.06530096
22MP0002876_abnormal_thyroid_physiology1.94820088
23MP0005083_abnormal_biliary_tract1.94641014
24MP0005375_adipose_tissue_phenotype1.94364572
25MP0003195_calcinosis1.90482804
26MP0004019_abnormal_vitamin_homeostasis1.74520789
27MP0005319_abnormal_enzyme/_coenzyme1.74147424
28MP0005334_abnormal_fat_pad1.63935908
29MP0005584_abnormal_enzyme/coenzyme_acti1.63875907
30MP0003705_abnormal_hypodermis_morpholog1.63106268
31MP0001764_abnormal_homeostasis1.53087578
32MP0008438_abnormal_cutaneous_collagen1.45079532
33MP0009115_abnormal_fat_cell1.44382616
34MP0003436_decreased_susceptibility_to1.41994734
35MP0001661_extended_life_span1.41947503
36MP0003186_abnormal_redox_activity1.41509419
37MP0000343_altered_response_to1.41105981
38* MP0005535_abnormal_body_temperature1.33037785
39MP0005451_abnormal_body_composition1.32616975
40MP0005164_abnormal_response_to1.30325488
41MP0002254_reproductive_system_inflammat1.29063538
42MP0003303_peritoneal_inflammation1.28283336
43MP0009643_abnormal_urine_homeostasis1.26551145
44MP0003690_abnormal_glial_cell1.25679018
45MP0006036_abnormal_mitochondrial_physio1.24976253
46MP0005275_abnormal_skin_tensile1.21314014
47MP0000013_abnormal_adipose_tissue1.20194904
48MP0005448_abnormal_energy_balance1.18465265
49* MP0002078_abnormal_glucose_homeostasis1.16126778
50MP0001533_abnormal_skeleton_physiology1.12824246
51MP0000003_abnormal_adipose_tissue1.11270762
52MP0004381_abnormal_hair_follicle1.10986548
53MP0002419_abnormal_innate_immunity1.10611904
54MP0002132_abnormal_respiratory_system1.08667814
55MP0009785_altered_susceptibility_to1.08412669
56MP0000604_amyloidosis1.07171638
57* MP0002970_abnormal_white_adipose1.07114123
58MP0003011_delayed_dark_adaptation1.06159793
59MP0000858_altered_metastatic_potential1.04448874
60MP0003868_abnormal_feces_composition1.02304665
61MP0003300_gastrointestinal_ulcer1.02040067
62MP0005647_abnormal_sex_gland1.01113102
63MP0002138_abnormal_hepatobiliary_system0.95821713
64MP0000598_abnormal_liver_morphology0.94483186
65MP0003646_muscle_fatigue0.93649111
66MP0004883_abnormal_blood_vessel0.91593623
67MP0009763_increased_sensitivity_to0.90987428
68MP0004947_skin_inflammation0.89498008
69MP0005025_abnormal_response_to0.88505318
70MP0000249_abnormal_blood_vessel0.88229451
71MP0003959_abnormal_lean_body0.87833598
72MP0009697_abnormal_copulation0.85381427
73MP0003329_amyloid_beta_deposits0.85237159
74MP0000685_abnormal_immune_system0.84593950
75MP0001756_abnormal_urination0.83918636
76MP0003656_abnormal_erythrocyte_physiolo0.82638380
77MP0001851_eye_inflammation0.81527587
78MP0003948_abnormal_gas_homeostasis0.79093158
79* MP0009642_abnormal_blood_homeostasis0.77614277
80MP0005330_cardiomyopathy0.75756937
81MP0005397_hematopoietic_system_phenotyp0.74705761
82MP0001545_abnormal_hematopoietic_system0.74705761
83* MP0002796_impaired_skin_barrier0.74218361
84MP0006138_congestive_heart_failure0.72853841
85MP0010234_abnormal_vibrissa_follicle0.72593172
86MP0009764_decreased_sensitivity_to0.72412951
87MP0005376_homeostasis/metabolism_phenot0.71841403
88MP0003724_increased_susceptibility_to0.70401282
89MP0010368_abnormal_lymphatic_system0.69032308
90MP0005266_abnormal_metabolism0.68877458
91MP0005000_abnormal_immune_tolerance0.68876995
92* MP0005452_abnormal_adipose_tissue0.68677624
93MP0002933_joint_inflammation0.67877536
94MP0003953_abnormal_hormone_level0.67808167
95MP0005636_abnormal_mineral_homeostasis0.67771586
96MP0002822_catalepsy0.66740675
97MP0001790_abnormal_immune_system0.66249228
98MP0005387_immune_system_phenotype0.66249228
99MP0002060_abnormal_skin_morphology0.65578705
100MP0003453_abnormal_keratinocyte_physiol0.64630337
101MP0001881_abnormal_mammary_gland0.64520084
102MP0008469_abnormal_protein_level0.63969642
103MP0005595_abnormal_vascular_smooth0.63486955
104MP0005058_abnormal_lysosome_morphology0.63062313
105MP0004782_abnormal_surfactant_physiolog0.62599064
106MP0000230_abnormal_systemic_arterial0.61353535
107MP0008260_abnormal_autophagy0.60370637
108MP0005379_endocrine/exocrine_gland_phen0.59394669
109MP0005385_cardiovascular_system_phenoty0.58195879
110MP0001544_abnormal_cardiovascular_syste0.58195879
111MP0009765_abnormal_xenobiotic_induced0.57616376
112MP0003566_abnormal_cell_adhesion0.57109711
113MP0002108_abnormal_muscle_morphology0.56831041
114MP0000751_myopathy0.56809803
115MP0002148_abnormal_hypersensitivity_rea0.55703458
116MP0001800_abnormal_humoral_immune0.55566601
117MP0005388_respiratory_system_phenotype0.55387590
118MP0002133_abnormal_respiratory_system0.55387590
119MP0008775_abnormal_heart_ventricle0.55368744
120MP0002638_abnormal_pupillary_reflex0.55221456
121MP0002909_abnormal_adrenal_gland0.55003850
122MP0009780_abnormal_chondrocyte_physiolo0.54554746
123MP0004087_abnormal_muscle_fiber0.52499490
124MP0005620_abnormal_muscle_contractility0.52352578
125MP0002332_abnormal_exercise_endurance0.50561749
126MP0004147_increased_porphyrin_level0.50109486
127MP0003075_altered_response_to0.49743045
128MP0006035_abnormal_mitochondrial_morpho0.49648372
129MP0004215_abnormal_myocardial_fiber0.49217743
130MP0002168_other_aberrant_phenotype0.48673393
131MP0002269_muscular_atrophy0.48351216
132MP0004272_abnormal_basement_membrane0.48348892
133MP0008874_decreased_physiological_sensi0.47374319
134MP0005084_abnormal_gallbladder_morpholo0.47370663
135MP0002136_abnormal_kidney_physiology0.46665176
136MP0008961_abnormal_basal_metabolism0.45214185
137MP0005167_abnormal_blood-brain_barrier0.44439871
138MP0000427_abnormal_hair_cycle0.42963189

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.68998489
2Xanthomatosis (HP:0000991)5.59692221
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.41513854
4Intrahepatic cholestasis (HP:0001406)5.36375826
5Hyperglycinuria (HP:0003108)5.36153406
6Hyperlipoproteinemia (HP:0010980)5.14788689
7Complement deficiency (HP:0004431)5.02831398
8Abnormality of serine family amino acid metabolism (HP:0010894)4.92306044
9Abnormality of glycine metabolism (HP:0010895)4.92306044
10Hyperammonemia (HP:0001987)4.67405280
11Ketosis (HP:0001946)4.65586390
12Hypobetalipoproteinemia (HP:0003563)4.64302976
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.60967168
14Prolonged partial thromboplastin time (HP:0003645)4.52229849
15Hyperglycinemia (HP:0002154)4.43008492
16Epidermoid cyst (HP:0200040)4.40533463
17Hypoalphalipoproteinemia (HP:0003233)4.39762247
18Hypoglycemic coma (HP:0001325)4.37833517
19Hypolipoproteinemia (HP:0010981)4.26857606
20Abnormality of fatty-acid metabolism (HP:0004359)4.18930425
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16907788
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91641582
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.89544901
24Ketoacidosis (HP:0001993)3.85871206
25Eczematoid dermatitis (HP:0000976)3.81631216
26Difficulty running (HP:0009046)3.57904565
27Abnormality of complement system (HP:0005339)3.57803237
28Hypercholesterolemia (HP:0003124)3.45031748
29Orchitis (HP:0100796)3.41130518
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.37028047
31Dicarboxylic aciduria (HP:0003215)3.37028047
32Increased IgE level (HP:0003212)3.35907957
33Oligomenorrhea (HP:0000876)3.32802355
34Joint hemorrhage (HP:0005261)3.29868756
35Hypertriglyceridemia (HP:0002155)3.29519986
36Abnormality of the common coagulation pathway (HP:0010990)3.28189321
37Myositis (HP:0100614)3.27420623
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26498579
39Recurrent gram-negative bacterial infections (HP:0005420)3.14261766
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.13192697
41Increased variability in muscle fiber diameter (HP:0003557)3.11352976
42Myoglobinuria (HP:0002913)3.04487110
43Acanthosis nigricans (HP:0000956)3.03733132
44Myocardial infarction (HP:0001658)2.97376942
45Abnormality of methionine metabolism (HP:0010901)2.96888433
46Abnormality of serum amino acid levels (HP:0003112)2.95081614
47Skin nodule (HP:0200036)2.91953687
48Retrobulbar optic neuritis (HP:0100654)2.91617757
49Optic neuritis (HP:0100653)2.91617757
50Fat malabsorption (HP:0002630)2.89656558
51Growth hormone excess (HP:0000845)2.87941251
52Polycythemia (HP:0001901)2.87517559
53Abnormal hemoglobin (HP:0011902)2.83241407
54Metabolic acidosis (HP:0001942)2.82411546
55Hydroxyprolinuria (HP:0003080)2.81913769
56Abnormality of proline metabolism (HP:0010907)2.81913769
57Increased serum pyruvate (HP:0003542)2.76616514
58Abnormality of the intrinsic pathway (HP:0010989)2.73227563
59Lethargy (HP:0001254)2.72747165
60Abnormality of purine metabolism (HP:0004352)2.70441567
61Delayed CNS myelination (HP:0002188)2.64202016
62Cerebral edema (HP:0002181)2.63134266
63Hemorrhage of the eye (HP:0011885)2.62520906
64Gingivitis (HP:0000230)2.60245188
65Bone cyst (HP:0012062)2.57255570
66Keratoconjunctivitis sicca (HP:0001097)2.53284895
67Hyperbilirubinemia (HP:0002904)2.52127053
68Long foot (HP:0001833)2.51712497
69Pancreatitis (HP:0001733)2.51537712
70Abnormality of nucleobase metabolism (HP:0010932)2.51499882
71Abnormality of skeletal muscle fiber size (HP:0012084)2.50784118
72Vertebral compression fractures (HP:0002953)2.47964919
73Generalized aminoaciduria (HP:0002909)2.47810170
74Prolonged bleeding time (HP:0003010)2.45877752
75Protrusio acetabuli (HP:0003179)2.44728524
76Conjugated hyperbilirubinemia (HP:0002908)2.44463547
77Systemic lupus erythematosus (HP:0002725)2.44070794
78Rhabdomyolysis (HP:0003201)2.41518055
79Gastrointestinal infarctions (HP:0005244)2.40748002
80Peritonitis (HP:0002586)2.38950546
81Recurrent abscess formation (HP:0002722)2.33316255
82Hypoglycemic seizures (HP:0002173)2.33158791
83Vomiting (HP:0002013)2.32970652
84Abnormality of alanine metabolism (HP:0010916)2.32862372
85Hyperalaninemia (HP:0003348)2.32862372
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32862372
87Abnormality of glycolysis (HP:0004366)2.32824236
88Nausea (HP:0002018)2.29227530
89Amyloidosis (HP:0011034)2.28272778
90Axonal loss (HP:0003447)2.27192931
91Keratoconjunctivitis (HP:0001096)2.26841709
92Brushfield spots (HP:0001088)2.26496519
93Abnormal gallbladder morphology (HP:0012437)2.26174552
94Cholelithiasis (HP:0001081)2.25819545
95Hepatosplenomegaly (HP:0001433)2.23419464
96Colitis (HP:0002583)2.22429662
97Abnormality of macrophages (HP:0004311)2.22307987
98Increased muscle lipid content (HP:0009058)2.21557453
99Hepatocellular carcinoma (HP:0001402)2.20225013
100Abnormal platelet volume (HP:0011876)2.18960540
101Abnormal cartilage morphology (HP:0002763)2.16899753
102Hyperglycemia (HP:0003074)2.13874703
103Abnormality of pyrimidine metabolism (HP:0004353)2.13616513
104Cholecystitis (HP:0001082)2.13167369
105Abnormal gallbladder physiology (HP:0012438)2.13167369
106Back pain (HP:0003418)2.13000240
107Gingival bleeding (HP:0000225)2.10772366
108Spontaneous abortion (HP:0005268)2.09211348
109Ectopia lentis (HP:0001083)2.09122417
110Gout (HP:0001997)2.08503765
111Pigmentary retinal degeneration (HP:0001146)2.08317040
112Hyperinsulinemic hypoglycemia (HP:0000825)2.07025847
113Right ventricular cardiomyopathy (HP:0011663)2.06782285
114Conjunctival hamartoma (HP:0100780)2.06371232
115Hypercortisolism (HP:0001578)2.06192816
116Steatorrhea (HP:0002570)2.02685812
117Sensorimotor neuropathy (HP:0007141)2.01323448
118Elevated erythrocyte sedimentation rate (HP:0003565)2.01178011
119Cupped ribs (HP:0000887)2.00835883
120Polyphagia (HP:0002591)2.00801007
121Toxemia of pregnancy (HP:0100603)2.00357747
122Insulin resistance (HP:0000855)2.00231354
123Acute hepatic failure (HP:0006554)2.00032148
124Subcapsular cataract (HP:0000523)1.99100196
125Recurrent bacterial skin infections (HP:0005406)1.98939657
126Acanthocytosis (HP:0001927)1.97796061
127Neonatal onset (HP:0003623)1.97137597
128Irritability (HP:0000737)1.96954429
129Rickets (HP:0002748)1.96274672
130Proximal tubulopathy (HP:0000114)1.95480379
131Increased purine levels (HP:0004368)1.94678377
132Hyperuricemia (HP:0002149)1.94678377
133Short nail (HP:0001799)1.94635897
134Glomerulopathy (HP:0100820)1.94374703
135Late onset (HP:0003584)1.93946956
136Renal cortical cysts (HP:0000803)1.93621310
137Gangrene (HP:0100758)1.93496517
138Polygenic inheritance (HP:0010982)1.92884812
139Abnormal eating behavior (HP:0100738)1.91121911
140Spastic diplegia (HP:0001264)1.91086754
141Vascular calcification (HP:0004934)1.90866700
142Insulin-resistant diabetes mellitus (HP:0000831)1.90415951
143Spontaneous hematomas (HP:0007420)1.88033957
144Increased mean platelet volume (HP:0011877)1.87411866
145Hepatic necrosis (HP:0002605)1.85776505
146Malnutrition (HP:0004395)1.85121616
147Pathologic fracture (HP:0002756)1.84908347
148Inflammation of the large intestine (HP:0002037)1.84658733
149Easy fatigability (HP:0003388)1.81641711
150Abnormality of carpal bone ossification (HP:0006257)1.81407259
151Nephritis (HP:0000123)1.81255104
152Stomatitis (HP:0010280)1.81230254
153Cardiovascular calcification (HP:0011915)1.79343717
154Prominent supraorbital ridges (HP:0000336)1.78974025
155Ovoid vertebral bodies (HP:0003300)1.78358678
156Elevated hepatic transaminases (HP:0002910)1.77036200
157Abnormality of the gallbladder (HP:0005264)1.75541365
158Mitral stenosis (HP:0001718)1.75516613
159Glomerulonephritis (HP:0000099)1.74628579
160Hypochromic microcytic anemia (HP:0004840)1.70780561
161Esophageal varix (HP:0002040)1.70739059
162Enlarged kidneys (HP:0000105)1.69035619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.30672763
2SIK14.47344567
3CAMK1D3.96185871
4TRIB33.91902377
5RIPK43.26504986
6ERN12.97915182
7CAMK1G2.83732735
8PDK32.77121598
9PDK42.77121598
10FGFR42.59476879
11INSRR2.46664662
12MST1R2.43607015
13PRPF4B1.99736140
14LMTK21.95524519
15BLK1.77449872
16PRKAA21.77022133
17TNK21.67949648
18PKN21.67532800
19FGFR21.61234592
20RIPK11.60970666
21PDK21.58464980
22FRK1.53360734
23ZAP701.52415879
24IRAK41.46496732
25MAP2K41.45909440
26LATS11.45435790
27PINK11.41473486
28MAP3K11.41110466
29MAP4K11.40906235
30JAK31.37913739
31FES1.36687979
32MAP3K111.30816490
33ERBB41.20486162
34MAPK111.20385535
35TESK11.19624963
36TAOK11.07563644
37DDR21.06383846
38TTN1.05548243
39PDPK11.04583611
40TIE11.03517566
41PIK3CA1.03258930
42DAPK21.01787415
43PRKAA11.01638890
44MET0.98958994
45HCK0.97126885
46JAK10.96261356
47CAMKK20.96020593
48PHKG20.95946389
49PHKG10.95946389
50FGFR30.94964405
51EPHA40.94732679
52JAK20.94526888
53YES10.92518030
54ABL20.90706958
55EPHB10.89575830
56KIT0.89180122
57MARK20.88837179
58MAP2K10.88088891
59NLK0.87832566
60NEK90.87666553
61MAP3K70.86752773
62MAP3K130.86154580
63FLT30.84785783
64PTK60.84736302
65MYLK0.84434476
66PIK3CG0.84077339
67PRKACG0.83160536
68BTK0.82611982
69ICK0.82398963
70PRKD20.79143540
71PDK10.78058083
72CDK60.77825748
73TAOK30.75670075
74IRAK10.70400228
75MAP3K60.69913668
76MAP2K30.69567812
77MAP3K30.68375029
78MAPK120.68101678
79OBSCN0.67832472
80PDGFRA0.67187167
81GRK50.65944961
82FER0.63528590
83GSK3A0.63261722
84EPHB20.62849630
85PTK2B0.62055618
86TYK20.61852959
87ADRBK10.60612655
88RAF10.60016549
89KSR20.59061516
90RET0.58753001
91PRKCZ0.58559858
92TAOK20.58417706
93SYK0.56454914
94LYN0.55792911
95PDGFRB0.55289768
96PRKCH0.54336127
97MAPK40.53628936
98TGFBR20.53309302
99LCK0.52973571
100MAPK70.52861219
101FGR0.51825936
102ARAF0.51409265
103KDR0.51354365
104PRKD10.51040290
105CDC42BPA0.50931094
106LATS20.50029898
107LRRK20.49998104
108IKBKE0.49397031
109PAK30.46178696
110IGF1R0.45851528
111MAPK30.45687456
112MAPKAPK30.45162579
113NTRK30.45013901
114SGK30.44819727
115MTOR0.44775201
116CAMKK10.44683885
117CDK90.44510895
118WNK10.44020846
119CAMK2G0.43628580
120CSF1R0.43564366
121STK38L0.43434294
122IRAK30.42786831
123MAP3K20.40356826
124CSK0.40000930
125MOS0.39352296
126PRKD30.38822166
127KSR10.38665564
128TRPM70.36288460
129STK380.36142891
130TBK10.35785254
131FGFR10.35373346
132SGK4940.33841946
133SGK2230.33841946
134PKN10.32909520
135CAMK10.31608640
136WNK40.30321801
137PTK20.29685176
138EPHA30.29364397
139ERBB20.28471274
140GRK60.27548345
141PRKACA0.26220516
142BMX0.25903995
143PRKG20.25795917
144CDK40.25714389
145STK110.24785520
146RPS6KA30.22381351
147MAP3K50.21257046

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.53293683
2Nitrogen metabolism_Homo sapiens_hsa009103.21266926
3Propanoate metabolism_Homo sapiens_hsa006403.15472109
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.07357606
5Fatty acid degradation_Homo sapiens_hsa000713.03070745
6PPAR signaling pathway_Homo sapiens_hsa033202.80576298
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73852820
8Fatty acid metabolism_Homo sapiens_hsa012122.67008463
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60982366
10Arginine biosynthesis_Homo sapiens_hsa002202.59356562
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54892949
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44500671
13Tryptophan metabolism_Homo sapiens_hsa003802.36638587
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30736627
15Butanoate metabolism_Homo sapiens_hsa006502.27138228
16Complement and coagulation cascades_Homo sapiens_hsa046102.10318870
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09778264
18Peroxisome_Homo sapiens_hsa041462.08834727
19beta-Alanine metabolism_Homo sapiens_hsa004101.96704628
20Pyruvate metabolism_Homo sapiens_hsa006201.95986908
21Fatty acid biosynthesis_Homo sapiens_hsa000611.95640601
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93922184
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75772710
24Caffeine metabolism_Homo sapiens_hsa002321.74914171
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74691080
26Fatty acid elongation_Homo sapiens_hsa000621.65022431
27Carbon metabolism_Homo sapiens_hsa012001.60564967
28Phenylalanine metabolism_Homo sapiens_hsa003601.58349396
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58213743
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52237376
31Chemical carcinogenesis_Homo sapiens_hsa052041.50521616
32Histidine metabolism_Homo sapiens_hsa003401.50379818
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49436037
34Staphylococcus aureus infection_Homo sapiens_hsa051501.48622721
35* Fat digestion and absorption_Homo sapiens_hsa049751.40592444
36Tyrosine metabolism_Homo sapiens_hsa003501.39657091
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.36814642
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35659526
39* Glycerolipid metabolism_Homo sapiens_hsa005611.32831350
40Retinol metabolism_Homo sapiens_hsa008301.28582259
41Bile secretion_Homo sapiens_hsa049761.25863474
42Starch and sucrose metabolism_Homo sapiens_hsa005001.24353240
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.21033648
44Sulfur metabolism_Homo sapiens_hsa009201.16392347
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15481069
46Biosynthesis of amino acids_Homo sapiens_hsa012301.14922227
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13516539
48ABC transporters_Homo sapiens_hsa020101.12458338
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08728445
50Vitamin B6 metabolism_Homo sapiens_hsa007501.06898967
51Selenocompound metabolism_Homo sapiens_hsa004500.98831165
52Malaria_Homo sapiens_hsa051440.91502970
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.91378108
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90152969
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85192008
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.84430213
57Osteoclast differentiation_Homo sapiens_hsa043800.80756718
58Acute myeloid leukemia_Homo sapiens_hsa052210.77642867
59Folate biosynthesis_Homo sapiens_hsa007900.77229509
60Lysine degradation_Homo sapiens_hsa003100.74890915
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73910015
62Arginine and proline metabolism_Homo sapiens_hsa003300.72291374
63Vitamin digestion and absorption_Homo sapiens_hsa049770.70325169
64Pentose phosphate pathway_Homo sapiens_hsa000300.68848768
65Sulfur relay system_Homo sapiens_hsa041220.68547374
66Steroid biosynthesis_Homo sapiens_hsa001000.67339328
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.64152741
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63800262
69AMPK signaling pathway_Homo sapiens_hsa041520.62624231
70Insulin resistance_Homo sapiens_hsa049310.59254748
71Glutathione metabolism_Homo sapiens_hsa004800.56730643
72Leishmaniasis_Homo sapiens_hsa051400.53519493
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.48775706
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47961821
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45536806
76Glucagon signaling pathway_Homo sapiens_hsa049220.44348215
77* Metabolic pathways_Homo sapiens_hsa011000.43687157
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.39487178
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.39357395
80Pertussis_Homo sapiens_hsa051330.37977606
81Linoleic acid metabolism_Homo sapiens_hsa005910.36619531
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35190868
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34870286
84Fructose and mannose metabolism_Homo sapiens_hsa000510.34732431
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33677087
86Tuberculosis_Homo sapiens_hsa051520.33413794
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32884848
88Insulin signaling pathway_Homo sapiens_hsa049100.32874052
89Other glycan degradation_Homo sapiens_hsa005110.31122599
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.31119745
91Toxoplasmosis_Homo sapiens_hsa051450.27288521
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25955268
93Galactose metabolism_Homo sapiens_hsa000520.24323091
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.24272281
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24008205
96Hepatitis C_Homo sapiens_hsa051600.23799154
97B cell receptor signaling pathway_Homo sapiens_hsa046620.23211461
98Chemokine signaling pathway_Homo sapiens_hsa040620.22930448
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21713259
100Phagosome_Homo sapiens_hsa041450.20232235
101FoxO signaling pathway_Homo sapiens_hsa040680.19952369
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.19258438
103Prion diseases_Homo sapiens_hsa050200.18088623
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17114638
105Platelet activation_Homo sapiens_hsa046110.15846957
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14674498
107TNF signaling pathway_Homo sapiens_hsa046680.12682671
108Prolactin signaling pathway_Homo sapiens_hsa049170.11375867
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06630062
110Type II diabetes mellitus_Homo sapiens_hsa049300.06117052
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.05358457
112Ovarian steroidogenesis_Homo sapiens_hsa049130.01085841
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1781146
114Mineral absorption_Homo sapiens_hsa04978-0.1780666
115Ether lipid metabolism_Homo sapiens_hsa00565-0.1555844
116Amoebiasis_Homo sapiens_hsa05146-0.1517324
117Parkinsons disease_Homo sapiens_hsa05012-0.1419111
118Alzheimers disease_Homo sapiens_hsa05010-0.1141092
119Oxidative phosphorylation_Homo sapiens_hsa00190-0.1048871
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0732916
121Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0604084
122Renin secretion_Homo sapiens_hsa04924-0.0571261
123One carbon pool by folate_Homo sapiens_hsa00670-0.0407324
124Protein digestion and absorption_Homo sapiens_hsa04974-0.0328174
125Renin-angiotensin system_Homo sapiens_hsa04614-0.0280357
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0058561
127Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0056975

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