DGCR14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.37541976
2DNA deamination (GO:0045006)4.30587946
3protein localization to kinetochore (GO:0034501)4.17471642
4mitotic metaphase plate congression (GO:0007080)4.13154553
5spliceosomal tri-snRNP complex assembly (GO:0000244)3.97487094
6formation of translation preinitiation complex (GO:0001731)3.96449921
7DNA strand elongation involved in DNA replication (GO:0006271)3.95251116
8regulation of spindle organization (GO:0090224)3.93397752
9regulation of chromatin binding (GO:0035561)3.86502800
10protein localization to chromosome, centromeric region (GO:0071459)3.83700234
11DNA strand elongation (GO:0022616)3.76248476
12ribosomal small subunit assembly (GO:0000028)3.73751197
13negative regulation of erythrocyte differentiation (GO:0045647)3.72720530
14metaphase plate congression (GO:0051310)3.71210274
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63311597
16mitotic sister chromatid segregation (GO:0000070)3.62845080
17kinetochore organization (GO:0051383)3.60680952
18regulation of mitotic spindle organization (GO:0060236)3.49132578
19viral transcription (GO:0019083)3.47446254
20spliceosomal snRNP assembly (GO:0000387)3.47054692
21GDP-mannose metabolic process (GO:0019673)3.46873239
22kinetochore assembly (GO:0051382)3.44444301
23purine nucleobase biosynthetic process (GO:0009113)3.43725854
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43557757
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41715999
26mitochondrion transport along microtubule (GO:0047497)3.41715999
27spliceosomal complex assembly (GO:0000245)3.41608901
28DNA unwinding involved in DNA replication (GO:0006268)3.39493996
29nucleobase biosynthetic process (GO:0046112)3.39408906
30translational termination (GO:0006415)3.39385569
31telomere maintenance via semi-conservative replication (GO:0032201)3.38518580
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38055683
33intracellular estrogen receptor signaling pathway (GO:0030520)3.36889850
34DNA replication checkpoint (GO:0000076)3.35474937
35establishment of chromosome localization (GO:0051303)3.34889403
36DNA replication initiation (GO:0006270)3.34095246
37negative regulation of chromosome segregation (GO:0051985)3.33865108
38mitotic chromosome condensation (GO:0007076)3.33801823
39negative regulation of RNA splicing (GO:0033119)3.32181599
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30918054
41negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30854899
42negative regulation of sister chromatid segregation (GO:0033046)3.30854899
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.30854899
44negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30854899
45mitotic nuclear envelope disassembly (GO:0007077)3.30360139
46mitotic spindle assembly checkpoint (GO:0007094)3.29903734
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29551849
48CENP-A containing nucleosome assembly (GO:0034080)3.28569768
49negative regulation of DNA-templated transcription, elongation (GO:0032785)3.27984706
50spindle assembly checkpoint (GO:0071173)3.27419732
51chaperone mediated protein folding requiring cofactor (GO:0051085)3.27036325
52translational initiation (GO:0006413)3.26450858
53ribosome biogenesis (GO:0042254)3.26027452
54histone H2A acetylation (GO:0043968)3.25929213
55chaperone-mediated protein transport (GO:0072321)3.25412040
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23313595
57positive regulation of protein homooligomerization (GO:0032464)3.22951470
58establishment of mitochondrion localization (GO:0051654)3.21667042
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21268243
60mitotic nuclear envelope reassembly (GO:0007084)3.19516062
61nuclear envelope reassembly (GO:0031468)3.19516062
62maturation of 5.8S rRNA (GO:0000460)3.19489153
63sister chromatid segregation (GO:0000819)3.19387731
64ribosomal large subunit biogenesis (GO:0042273)3.18955743
65spindle checkpoint (GO:0031577)3.18938100
66ribosomal small subunit biogenesis (GO:0042274)3.18541246
67peptidyl-arginine omega-N-methylation (GO:0035247)3.18529152
68translational elongation (GO:0006414)3.18519702
69ribonucleoprotein complex biogenesis (GO:0022613)3.18143226
70negative regulation of ligase activity (GO:0051352)3.15543371
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15543371
72negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14971701
73regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14612923
74mitotic spindle checkpoint (GO:0071174)3.12301717
75chromatin remodeling at centromere (GO:0031055)3.11516625
76proteasome assembly (GO:0043248)3.10938670
77protein retention in ER lumen (GO:0006621)3.10151820
78* mRNA splicing, via spliceosome (GO:0000398)3.07566972
79* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.07566972
80telomere maintenance via recombination (GO:0000722)3.07428314
81* RNA splicing, via transesterification reactions (GO:0000375)3.07122272
82DNA replication-independent nucleosome organization (GO:0034724)3.07087933
83DNA replication-independent nucleosome assembly (GO:0006336)3.07087933
84nuclear envelope disassembly (GO:0051081)3.06422846
85membrane disassembly (GO:0030397)3.06422846
86regulation of chromosome segregation (GO:0051983)3.05895054
87attachment of spindle microtubules to kinetochore (GO:0008608)3.05138673
88viral protein processing (GO:0019082)3.04468948
89rRNA processing (GO:0006364)3.03920206
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03721446
91pentose metabolic process (GO:0019321)2.99772201
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.97102043
93termination of RNA polymerase III transcription (GO:0006386)2.97102043
94rRNA metabolic process (GO:0016072)2.95764925
95negative regulation of B cell apoptotic process (GO:0002903)2.95148667
96mitotic recombination (GO:0006312)2.95087304
97pentose-phosphate shunt (GO:0006098)2.92790670
98negative regulation of mRNA processing (GO:0050686)2.92597365
99protein localization to chromosome (GO:0034502)2.92014981
100nuclear pore organization (GO:0006999)2.91993098
101regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90949018
102mitochondrial fusion (GO:0008053)2.90324429
103UV protection (GO:0009650)2.89968825
104regulation of mitotic sister chromatid separation (GO:0010965)2.89931117
105regulation of mitotic sister chromatid segregation (GO:0033047)2.89931117
106regulation of sister chromatid segregation (GO:0033045)2.89931117
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.88609607
108ncRNA 3-end processing (GO:0043628)2.88317001
109ribosome assembly (GO:0042255)2.88103009
110histone arginine methylation (GO:0034969)2.87499200
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87126296
112pseudouridine synthesis (GO:0001522)2.86368131
113viral mRNA export from host cell nucleus (GO:0046784)2.85696961
114telomere maintenance via telomere lengthening (GO:0010833)2.85576041
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84448099
116cellular protein complex disassembly (GO:0043624)2.84215444
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82039980
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81836866
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80356405
120COPI coating of Golgi vesicle (GO:0048205)2.79276299
121Golgi transport vesicle coating (GO:0048200)2.79276299
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78386289
1233-UTR-mediated mRNA stabilization (GO:0070935)2.77727643
124cotranslational protein targeting to membrane (GO:0006613)2.77044531
125virion assembly (GO:0019068)2.76832780
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76725563
127peptidyl-arginine methylation (GO:0018216)2.76650009
128peptidyl-arginine N-methylation (GO:0035246)2.76650009
129protein complex disassembly (GO:0043241)2.75472995
130cullin deneddylation (GO:0010388)2.75184952
131positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.74339256
132pyrimidine-containing compound salvage (GO:0008655)2.67973328
133pyrimidine nucleoside salvage (GO:0043097)2.67973328
134response to peptidoglycan (GO:0032494)2.67842153
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.67687998
136tRNA methylation (GO:0030488)2.66061373
137histone H4 deacetylation (GO:0070933)2.65883247
138regulation of T-helper 2 cell differentiation (GO:0045628)2.62869969
139protein-DNA complex disassembly (GO:0032986)2.62398819
140nucleosome disassembly (GO:0006337)2.62398819
141negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62268842
142nucleobase-containing small molecule interconversion (GO:0015949)2.59611658
143protein insertion into membrane (GO:0051205)2.59126479
144regulation of mitochondrial translation (GO:0070129)2.58900876
145regulation of NFAT protein import into nucleus (GO:0051532)2.53946076
146de novo posttranslational protein folding (GO:0051084)2.53689204
147protein maturation by protein folding (GO:0022417)2.49643246
148regulation of release of cytochrome c from mitochondria (GO:0090199)2.49549985
149modulation by virus of host process (GO:0019054)2.49097544
150dosage compensation (GO:0007549)2.48052271
1512-deoxyribonucleotide biosynthetic process (GO:0009265)2.47896762
152deoxyribose phosphate biosynthetic process (GO:0046385)2.47896762
153proline biosynthetic process (GO:0006561)2.45866036
154negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.45021153
155iron-sulfur cluster assembly (GO:0016226)2.44676782
156metallo-sulfur cluster assembly (GO:0031163)2.44676782
157apoptotic process involved in morphogenesis (GO:0060561)2.44460152
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43933388
159cellular response to virus (GO:0098586)2.43033743
160guanosine-containing compound biosynthetic process (GO:1901070)2.42023290
161heterochromatin organization (GO:0070828)2.42004961
162regulation of translational termination (GO:0006449)2.41441265
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.41136929
164NADPH regeneration (GO:0006740)2.37165171
165positive regulation by symbiont of host defense response (GO:0052509)2.35743789
166modulation by symbiont of host defense response (GO:0052031)2.35743789
167modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35743789
168modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35743789
169positive regulation by organism of defense response of other organism involved in symbiotic interact2.35743789
170modulation by symbiont of host immune response (GO:0052553)2.35743789
171de novo protein folding (GO:0006458)2.32696577
172regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)2.31790789
173nucleotide salvage (GO:0043173)2.30601552
174protein targeting to mitochondrion (GO:0006626)2.30374394
175chromosome condensation (GO:0030261)2.30173696
176amino sugar catabolic process (GO:0046348)2.29136582
177rRNA modification (GO:0000154)2.28032211
178entrainment of circadian clock by photoperiod (GO:0043153)2.27761844
179positive regulation of DNA-templated transcription, elongation (GO:0032786)2.26801935
180DNA topological change (GO:0006265)2.25131888
181establishment of viral latency (GO:0019043)2.24614545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41762332
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.30161520
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93059719
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83642958
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06334508
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03470388
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.99381750
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99321575
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.95898716
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93706812
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.90575828
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82587027
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81090860
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77778099
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71562252
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61271547
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60901772
18XRN2_22483619_ChIP-Seq_HELA_Human2.57864546
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29104335
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25563439
21* VDR_23849224_ChIP-Seq_CD4+_Human2.19412186
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19254492
23CIITA_25753668_ChIP-Seq_RAJI_Human2.18062256
24LXR_22292898_ChIP-Seq_THP-1_Human2.14446659
25GABP_19822575_ChIP-Seq_HepG2_Human2.08576777
26MYC_22102868_ChIP-Seq_BL_Human2.05217653
27DCP1A_22483619_ChIP-Seq_HELA_Human2.04423832
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00735215
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98772971
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97365619
31FOXP3_21729870_ChIP-Seq_TREG_Human1.96161624
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92819036
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92243360
34TTF2_22483619_ChIP-Seq_HELA_Human1.87169398
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85841438
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.84963580
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82589788
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.82237484
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81029416
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80985318
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79221932
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.76788290
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75668105
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.71088344
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70038179
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.68868013
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68347240
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64669964
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63168986
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.63056632
51AR_21909140_ChIP-Seq_LNCAP_Human1.60953309
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59714752
53P68_20966046_ChIP-Seq_HELA_Human1.58850763
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58411931
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57000365
56KDM2B_26808549_Chip-Seq_DND41_Human1.56240459
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55818792
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54996027
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52815542
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52329905
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50992899
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50530748
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.48438557
64VDR_21846776_ChIP-Seq_THP-1_Human1.46089466
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45876901
66KDM5A_27292631_Chip-Seq_BREAST_Human1.45529591
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.43045745
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42513486
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41228049
70BCL6_27268052_Chip-Seq_Bcells_Human1.40974781
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.40496660
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40430606
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39874465
74RACK7_27058665_Chip-Seq_MCF-7_Human1.38675351
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.38590730
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37197145
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36188496
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35382288
79NCOR1_26117541_ChIP-Seq_K562_Human1.34080439
80TCF7_22412390_ChIP-Seq_EML_Mouse1.33784928
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33649162
82ELK1_19687146_ChIP-ChIP_HELA_Human1.33470502
83BCOR_27268052_Chip-Seq_Bcells_Human1.33275219
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28129072
85MAF_26560356_Chip-Seq_TH1_Human1.27781482
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26816902
87VDR_24763502_ChIP-Seq_THP-1_Human1.26547619
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24939519
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24896247
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24578356
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21384822
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20195758
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19995131
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19500275
95TFEB_21752829_ChIP-Seq_HELA_Human1.17481230
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16944515
97SMC4_20622854_ChIP-Seq_HELA_Human1.16932681
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16893039
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16797481
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16795497
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16115340
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16039778
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.13554044
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13239386
105KDM2B_26808549_Chip-Seq_K562_Human1.12720071
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12343859
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.12166989
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11926671
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11791527
110ZNF263_19887448_ChIP-Seq_K562_Human1.11420189
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10431601
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09975567
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09782147
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09054341
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08982755
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08514047
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08499577
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06841896
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05764603
120SPI1_23547873_ChIP-Seq_NB4_Human1.04944381
121PHF8_20622854_ChIP-Seq_HELA_Human1.04539192
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04520342
123* RARA_24833708_ChIP-Seq_LIVER_Mouse1.04295813
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01810815
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01086982
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.98568310
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96349618
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95027091
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.94750849
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92040875
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91099534
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90337426
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.89684516
134UTX_26944678_Chip-Seq_JUKART_Human0.89567153
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89469070
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.87015033
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86640139
138MAF_26560356_Chip-Seq_TH2_Human0.85953501
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85679031
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85218340
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85024908
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84760200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67063239
2MP0003111_abnormal_nucleus_morphology3.95984002
3MP0004957_abnormal_blastocyst_morpholog3.88390709
4MP0003077_abnormal_cell_cycle3.85341966
5MP0010094_abnormal_chromosome_stability3.79809002
6MP0005058_abnormal_lysosome_morphology3.27947979
7MP0008058_abnormal_DNA_repair2.92818431
8MP0008057_abnormal_DNA_replication2.72480502
9MP0008007_abnormal_cellular_replicative2.60893825
10MP0008932_abnormal_embryonic_tissue2.55940066
11MP0002653_abnormal_ependyma_morphology2.52308810
12MP0005451_abnormal_body_composition2.48424951
13MP0010030_abnormal_orbit_morphology2.45868471
14MP0003436_decreased_susceptibility_to2.41621083
15MP0001730_embryonic_growth_arrest2.31341946
16MP0003303_peritoneal_inflammation2.26512700
17MP0000350_abnormal_cell_proliferation2.12981828
18MP0003806_abnormal_nucleotide_metabolis2.12307779
19MP0004808_abnormal_hematopoietic_stem2.03854069
20MP0003123_paternal_imprinting1.95200824
21MP0002396_abnormal_hematopoietic_system1.94919861
22MP0003172_abnormal_lysosome_physiology1.92851806
23MP0009278_abnormal_bone_marrow1.91248507
24MP0009840_abnormal_foam_cell1.85604876
25MP0003763_abnormal_thymus_physiology1.81811177
26MP0002822_catalepsy1.78384195
27MP0001545_abnormal_hematopoietic_system1.75567036
28MP0005397_hematopoietic_system_phenotyp1.75567036
29MP0008877_abnormal_DNA_methylation1.74432909
30MP0000490_abnormal_crypts_of1.71686037
31MP0008789_abnormal_olfactory_epithelium1.70706803
32MP0002249_abnormal_larynx_morphology1.69793959
33MP0008260_abnormal_autophagy1.69161566
34MP0001697_abnormal_embryo_size1.69012593
35MP0003221_abnormal_cardiomyocyte_apopto1.67573879
36MP0005499_abnormal_olfactory_system1.66303393
37MP0005394_taste/olfaction_phenotype1.66303393
38MP0003567_abnormal_fetal_cardiomyocyte1.63964570
39MP0004858_abnormal_nervous_system1.63695767
40MP0002080_prenatal_lethality1.61230512
41MP0002085_abnormal_embryonic_tissue1.54298247
42MP0002398_abnormal_bone_marrow1.53977466
43MP0004185_abnormal_adipocyte_glucose1.51754396
44MP0000313_abnormal_cell_death1.51733292
45MP0000703_abnormal_thymus_morphology1.51705857
46MP0005380_embryogenesis_phenotype1.51396801
47MP0001672_abnormal_embryogenesis/_devel1.51396801
48MP0003786_premature_aging1.49450935
49MP0009333_abnormal_splenocyte_physiolog1.47627785
50MP0006035_abnormal_mitochondrial_morpho1.45479666
51MP0001853_heart_inflammation1.44803837
52MP0005501_abnormal_skin_physiology1.37081702
53MP0003984_embryonic_growth_retardation1.37065985
54MP0002019_abnormal_tumor_incidence1.36284397
55MP0010352_gastrointestinal_tract_polyps1.35977010
56MP0003121_genomic_imprinting1.35119805
57MP0002088_abnormal_embryonic_growth/wei1.34322097
58MP0002084_abnormal_developmental_patter1.30032799
59MP0003828_pulmonary_edema1.29971394
60MP0005671_abnormal_response_to1.27210891
61MP0002722_abnormal_immune_system1.26103909
62MP0002210_abnormal_sex_determination1.24304131
63MP0003705_abnormal_hypodermis_morpholog1.19238455
64MP0003315_abnormal_perineum_morphology1.18913923
65MP0005025_abnormal_response_to1.18143844
66MP0000685_abnormal_immune_system1.17668962
67MP0000689_abnormal_spleen_morphology1.16897287
68MP0002086_abnormal_extraembryonic_tissu1.13921105
69MP0003191_abnormal_cellular_cholesterol1.12296810
70MP0002429_abnormal_blood_cell1.10228457
71MP0003119_abnormal_digestive_system1.10217190
72MP0000759_abnormal_skeletal_muscle1.10192058
73MP0000750_abnormal_muscle_regeneration1.10161622
74MP0003453_abnormal_keratinocyte_physiol1.09413887
75MP0001145_abnormal_male_reproductive1.08986980
76MP0001929_abnormal_gametogenesis1.08944390
77MP0006036_abnormal_mitochondrial_physio1.08154244
78MP0006292_abnormal_olfactory_placode1.07931555
79MP0000716_abnormal_immune_system1.06102581
80MP0000681_abnormal_thyroid_gland1.02893170
81MP0002419_abnormal_innate_immunity1.02757496
82MP0004197_abnormal_fetal_growth/weight/1.00459206
83MP0001849_ear_inflammation0.99980002
84MP0000343_altered_response_to0.99048937
85MP0002132_abnormal_respiratory_system0.98978992
86MP0000858_altered_metastatic_potential0.97912617
87MP0005621_abnormal_cell_physiology0.97607379
88MP0005464_abnormal_platelet_physiology0.96080918
89MP0004947_skin_inflammation0.95425362
90MP0003718_maternal_effect0.95254936
91MP0010307_abnormal_tumor_latency0.94674441
92MP0002420_abnormal_adaptive_immunity0.92922243
93MP0004510_myositis0.92548271
94MP0001727_abnormal_embryo_implantation0.91947899
95MP0001529_abnormal_vocalization0.91330242
96MP0001819_abnormal_immune_cell0.90541327
97MP0001293_anophthalmia0.89902239
98MP0002148_abnormal_hypersensitivity_rea0.89873893
99MP0005384_cellular_phenotype0.89754962
100MP0003938_abnormal_ear_development0.87850136
101MP0000653_abnormal_sex_gland0.87195674
102MP0002102_abnormal_ear_morphology0.87117687
103MP0001873_stomach_inflammation0.86346963
104MP0003329_amyloid_beta_deposits0.86052456
105MP0001764_abnormal_homeostasis0.85688229
106MP0002796_impaired_skin_barrier0.85179490
107MP0000747_muscle_weakness0.84528613
108MP0001790_abnormal_immune_system0.82656993
109MP0005387_immune_system_phenotype0.82656993
110MP0003861_abnormal_nervous_system0.82608810
111MP0000465_gastrointestinal_hemorrhage0.81289208
112MP0004811_abnormal_neuron_physiology0.81116170
113MP0000003_abnormal_adipose_tissue0.81034492
114MP0000678_abnormal_parathyroid_gland0.80379587
115MP0003115_abnormal_respiratory_system0.79608393
116MP0005410_abnormal_fertilization0.78807059
117MP0003942_abnormal_urinary_system0.78762838
118MP0004233_abnormal_muscle_weight0.77658764
119MP0001800_abnormal_humoral_immune0.77410696
120MP0001188_hyperpigmentation0.77364642
121MP0000358_abnormal_cell_content/0.76788498
122MP0009764_decreased_sensitivity_to0.76196026
123MP0002723_abnormal_immune_serum0.74466928
124MP0003186_abnormal_redox_activity0.73562780
125MP0002452_abnormal_antigen_presenting0.72569874
126MP0009931_abnormal_skin_appearance0.72559334
127MP0003724_increased_susceptibility_to0.71818626
128MP0003890_abnormal_embryonic-extraembry0.71792460
129MP0003943_abnormal_hepatobiliary_system0.71616041
130MP0002160_abnormal_reproductive_system0.70672135
131MP0003646_muscle_fatigue0.70642828
132MP0001119_abnormal_female_reproductive0.68505772
133MP0002932_abnormal_joint_morphology0.66693216
134MP0002405_respiratory_system_inflammati0.66685700
135MP0000049_abnormal_middle_ear0.65362839
136MP0003698_abnormal_male_reproductive0.63097992
137MP0003122_maternal_imprinting0.62214272
138MP0002751_abnormal_autonomic_nervous0.61653065
139MP0002114_abnormal_axial_skeleton0.59477422
140MP0003866_abnormal_defecation0.58363401
141MP0009672_abnormal_birth_weight0.57853112
142MP0005000_abnormal_immune_tolerance0.57474773
143MP0000428_abnormal_craniofacial_morphol0.56719905
144MP0004133_heterotaxia0.56022294
145MP0001348_abnormal_lacrimal_gland0.55824506
146MP0005023_abnormal_wound_healing0.55684879
147MP0002161_abnormal_fertility/fecundity0.53564160
148MP0005076_abnormal_cell_differentiation0.53158964

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)5.12291197
2Abnormal gallbladder physiology (HP:0012438)4.17992961
3Cholecystitis (HP:0001082)4.17992961
4Hypertensive crisis (HP:0100735)4.08370923
5Colon cancer (HP:0003003)3.86569205
6Hyperthyroidism (HP:0000836)3.85936143
7Patellar aplasia (HP:0006443)3.79707564
8Ragged-red muscle fibers (HP:0003200)3.69186726
9Reticulocytopenia (HP:0001896)3.65929529
10Aplasia/Hypoplasia of the patella (HP:0006498)3.60361168
11Cerebral hypomyelination (HP:0006808)3.40287438
12Birth length less than 3rd percentile (HP:0003561)3.39609351
13Selective tooth agenesis (HP:0001592)3.36310619
14Microvesicular hepatic steatosis (HP:0001414)3.25341421
15Breast hypoplasia (HP:0003187)3.20155067
16Abnormal large intestine physiology (HP:0012700)3.17752285
17Obstructive lung disease (HP:0006536)3.17433224
18Chronic obstructive pulmonary disease (HP:0006510)3.17433224
19Seborrheic dermatitis (HP:0001051)3.15764082
20Bowel incontinence (HP:0002607)3.07662162
21Achilles tendon contracture (HP:0001771)2.96519586
22Rough bone trabeculation (HP:0100670)2.94752694
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.93151946
24Progressive muscle weakness (HP:0003323)2.91532320
25Atelectasis (HP:0100750)2.85081355
26Aplastic anemia (HP:0001915)2.84849312
27Long palpebral fissure (HP:0000637)2.77374605
28Broad distal phalanx of finger (HP:0009836)2.75945751
29Abnormality of cells of the erythroid lineage (HP:0012130)2.64072347
30Hypoparathyroidism (HP:0000829)2.63495773
31Abnormality of the anterior horn cell (HP:0006802)2.63174514
32Degeneration of anterior horn cells (HP:0002398)2.63174514
33Recurrent bacterial skin infections (HP:0005406)2.56308683
34Reticulocytosis (HP:0001923)2.56064845
35Abnormality of the ileum (HP:0001549)2.55950175
36Abnormal number of erythroid precursors (HP:0012131)2.54607184
37Abnormality of the labia minora (HP:0012880)2.54070825
38Neoplasm of the pancreas (HP:0002894)2.53385929
39Easy fatigability (HP:0003388)2.50449603
40Oral leukoplakia (HP:0002745)2.49795817
41Poikiloderma (HP:0001029)2.49227573
42Deep palmar crease (HP:0006191)2.49031251
43Carpal bone hypoplasia (HP:0001498)2.48326840
44Petechiae (HP:0000967)2.48004685
45Abnormality of the tricuspid valve (HP:0001702)2.47659983
46Meckel diverticulum (HP:0002245)2.47618375
47Abnormality of the Achilles tendon (HP:0005109)2.44113123
48Pallor (HP:0000980)2.37487396
49Abnormality of the preputium (HP:0100587)2.34581113
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34482910
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.31854222
52Peripheral hypomyelination (HP:0007182)2.30577421
53Aplasia/Hypoplasia of the thymus (HP:0010515)2.30172175
54Recurrent abscess formation (HP:0002722)2.29687953
55Medulloblastoma (HP:0002885)2.29424778
56Basal cell carcinoma (HP:0002671)2.28324755
57Trismus (HP:0000211)2.27657893
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.26770036
59Thrombocytosis (HP:0001894)2.26737053
60Mediastinal lymphadenopathy (HP:0100721)2.26630737
61Abnormality of macrophages (HP:0004311)2.24692577
62Distal upper limb amyotrophy (HP:0007149)2.22074444
63Upper limb amyotrophy (HP:0009129)2.22074444
64Myelodysplasia (HP:0002863)2.21854503
65Abnormal lung lobation (HP:0002101)2.21244559
66Increased nuchal translucency (HP:0010880)2.20492916
67Tracheoesophageal fistula (HP:0002575)2.19843555
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19831738
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19831738
70Entropion (HP:0000621)2.19332593
71Abnormality of reticulocytes (HP:0004312)2.18798127
72Premature graying of hair (HP:0002216)2.17423853
73Abnormal number of incisors (HP:0011064)2.17170213
74Microretrognathia (HP:0000308)2.15526250
75Duodenal stenosis (HP:0100867)2.15491152
76Small intestinal stenosis (HP:0012848)2.15491152
77Cholelithiasis (HP:0001081)2.15321803
78Ependymoma (HP:0002888)2.15201017
79Premature ovarian failure (HP:0008209)2.15023109
80Absent radius (HP:0003974)2.15021504
81Sparse lateral eyebrow (HP:0005338)2.14174564
82Postnatal microcephaly (HP:0005484)2.12680910
83Bulbar palsy (HP:0001283)2.12551955
84Bone marrow hypocellularity (HP:0005528)2.11812639
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.09849649
86Absent epiphyses (HP:0010577)2.09849649
87Centrally nucleated skeletal muscle fibers (HP:0003687)2.08929096
88Abnormality of glycolysis (HP:0004366)2.08837210
89Increased serum pyruvate (HP:0003542)2.08837210
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.08619255
91Abnormality of glycolipid metabolism (HP:0010969)2.08619255
92Abnormality of liposaccharide metabolism (HP:0010968)2.08619255
93Hand muscle atrophy (HP:0009130)2.08243689
94Personality changes (HP:0000751)2.07129608
95Pointed chin (HP:0000307)2.06996414
96Cellular immunodeficiency (HP:0005374)2.06772823
97Abnormality of the umbilical cord (HP:0010881)2.06065857
98High anterior hairline (HP:0009890)2.05040865
99Proximal placement of thumb (HP:0009623)2.04645349
100Upper motor neuron abnormality (HP:0002127)2.03671614
101Eczematoid dermatitis (HP:0000976)2.03309430
102Renal duplication (HP:0000075)2.02939112
103Lymphoma (HP:0002665)2.02150697
104Aplasia involving forearm bones (HP:0009822)2.02005089
105Absent forearm bone (HP:0003953)2.02005089
106Cortical dysplasia (HP:0002539)2.00233272
107Hyperacusis (HP:0010780)2.00106871
108Absent thumb (HP:0009777)1.99274074
109Cellulitis (HP:0100658)1.98744074
110Myopathic facies (HP:0002058)1.98542001
111Severe combined immunodeficiency (HP:0004430)1.98356359
112Increased serum ferritin (HP:0003281)1.97005208
113Facial hemangioma (HP:0000329)1.96555205
114Self-mutilation (HP:0000742)1.96188329
115Premature skin wrinkling (HP:0100678)1.95682099
116Squamous cell carcinoma (HP:0002860)1.95336304
117Shoulder girdle muscle weakness (HP:0003547)1.94694896
118Triphalangeal thumb (HP:0001199)1.94651814
119Delusions (HP:0000746)1.94367691
120Abnormality of the gallbladder (HP:0005264)1.92239774
121Amaurosis fugax (HP:0100576)1.91920029
122Upper limb muscle weakness (HP:0003484)1.91100117
123Combined immunodeficiency (HP:0005387)1.90979786
124Atresia of the external auditory canal (HP:0000413)1.90697328
125Hypoplastic pelvis (HP:0008839)1.90430607
126Prominent nose (HP:0000448)1.90371513
127Gastrointestinal dysmotility (HP:0002579)1.90128324
128Agnosia (HP:0010524)1.89417896
129Macrocytic anemia (HP:0001972)1.89398928
130Abnormality of chromosome stability (HP:0003220)1.88967649
131IgM deficiency (HP:0002850)1.88373756
132Patellar dislocation (HP:0002999)1.87970203
133Difficulty climbing stairs (HP:0003551)1.87500510
134Abnormal trabecular bone morphology (HP:0100671)1.87175054
135Hepatosplenomegaly (HP:0001433)1.86658966
136Pustule (HP:0200039)1.86419001
137Secondary amenorrhea (HP:0000869)1.86366765
138Chromsome breakage (HP:0040012)1.86273318
139Broad alveolar ridges (HP:0000187)1.86228032
140Type I transferrin isoform profile (HP:0003642)1.85210052
141Sloping forehead (HP:0000340)1.85196930
142Cleft eyelid (HP:0000625)1.85109128
143Muscle fiber atrophy (HP:0100295)1.84370210
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.83984495
145Disproportionate tall stature (HP:0001519)1.83578004
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83498830
147Abnormality of alanine metabolism (HP:0010916)1.83394279
148Hyperalaninemia (HP:0003348)1.83394279
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83394279
150Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81848640
151Short 4th metacarpal (HP:0010044)1.81848640
152Overlapping toe (HP:0001845)1.81820929
153Stridor (HP:0010307)1.81536341
154Deviation of the thumb (HP:0009603)1.81254990
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81109128
156Distal lower limb amyotrophy (HP:0008944)1.80945546
157Elevated erythrocyte sedimentation rate (HP:0003565)1.79768636
158Abnormally folded helix (HP:0008544)1.79057273
159Increased IgE level (HP:0003212)1.77448014
160Nasal polyposis (HP:0100582)1.76706300
161Prolonged neonatal jaundice (HP:0006579)1.76681243
162Severe visual impairment (HP:0001141)1.75464701
163Abnormality of abdominal situs (HP:0011620)1.74865134
164Abdominal situs inversus (HP:0003363)1.74865134
165B lymphocytopenia (HP:0010976)1.74411871
166Abnormality of B cell number (HP:0010975)1.74411871
167Neuronal loss in central nervous system (HP:0002529)1.73357337
168Apathy (HP:0000741)1.73322554
169Diminished motivation (HP:0000745)1.73175449
170Progressive external ophthalmoplegia (HP:0000590)1.73001057
171Abnormality of the alveolar ridges (HP:0006477)1.72661042
172Abnormality of the columella (HP:0009929)1.72505490
173Glossoptosis (HP:0000162)1.72196020
174Slender long bone (HP:0003100)1.72195952
175Rhabdomyosarcoma (HP:0002859)1.71974095
176Abnormality of the duodenum (HP:0002246)1.71688584
177Impulsivity (HP:0100710)1.71023190
178Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70848485
179Supernumerary spleens (HP:0009799)1.70150043
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69146564
181Type 2 muscle fiber atrophy (HP:0003554)1.66083433
182Overfolded helix (HP:0000396)1.64580928
183Increased IgM level (HP:0003496)1.63544828
184Pelvic girdle muscle weakness (HP:0003749)1.63196728
185Abnormal gallbladder morphology (HP:0012437)1.62465430
186Insomnia (HP:0100785)1.61311432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.26021877
2WEE13.65776811
3IRAK33.37761251
4TESK23.31694816
5CDC73.05050493
6NEK23.00289770
7ARAF2.83597438
8PRPF4B2.62209583
9SMG12.49816829
10EIF2AK12.49006176
11BCKDK2.32489012
12TLK12.23703370
13CCNB12.09149667
14ACVR1B2.01335894
15KSR21.98612977
16TTK1.98508952
17PLK11.96313059
18EEF2K1.81048720
19MAP3K101.75028451
20DYRK31.74453320
21ERN11.73089290
22RPS6KA41.68747649
23PASK1.66844564
24MAP4K11.65306356
25TSSK61.63045559
26TAOK11.61949830
27STK161.60685539
28SIK21.60284751
29PAK41.55993268
30MUSK1.53406819
31SIK31.49723518
32AURKB1.47153549
33RIPK41.44136147
34NME21.40477457
35ATR1.39236888
36CDK71.38707328
37KDR1.38461654
38STK101.37373002
39BRSK11.36508525
40PLK41.32233058
41MAP3K61.31667063
42TESK11.30186979
43SIK11.29654598
44NEK11.29282223
45TBK11.28494861
46CDK121.27448769
47AURKA1.27168089
48MARK21.27083584
49VRK11.26656619
50CHEK21.21831448
51PAK61.21023076
52IRAK41.20394418
53MKNK11.20281164
54BRSK21.19761193
55SRPK11.19290051
56UHMK11.18896930
57PDK21.16243310
58ZAP701.09180905
59DYRK21.08855676
60MAPKAPK31.08165754
61LIMK11.05382788
62MAP3K81.04568564
63PIM21.03268153
64CLK11.03201256
65MAP3K130.98995402
66PLK30.97150318
67CHEK10.93560372
68PAK10.93548682
69MAP3K30.92977416
70BRAF0.90941925
71TAOK20.90783213
72EIF2AK30.89361757
73MAP3K120.88403646
74RPS6KB20.84446534
75VRK20.83583984
76BMX0.83493782
77PDK30.79904194
78PDK40.79904194
79IRAK20.77625306
80MAP3K90.77492951
81MKNK20.77135858
82PRKD20.76011106
83MAP3K110.75711357
84LRRK20.74967802
85PDPK10.74448162
86STK380.73420596
87TNK20.72124129
88CDK20.71315849
89MAP3K10.71182628
90ILK0.70983364
91RPS6KA20.70719910
92CDK40.70399341
93DAPK10.68317212
94MAPK110.67948741
95CDK11A0.66396456
96ABL20.64413361
97MOS0.64351676
98MARK30.64177394
99MELK0.62861914
100ICK0.62529888
101TGFBR10.60681985
102MTOR0.60484985
103CDK190.60188610
104MAP4K20.56927218
105CDK140.56875081
106JAK30.56859410
107CDK10.56700228
108CDK150.56097054
109CSK0.54626151
110MINK10.54513162
111PKN20.53973543
112TXK0.53850421
113MAP3K50.53508879
114STK40.52824910
115RPS6KC10.52595805
116RPS6KL10.52595805
117PDK10.52505975
118TRIB30.51101228
119RPS6KA10.50575463
120EPHB10.49203355
121NME10.48489368
122TYK20.47730275
123CSNK2A20.47454704
124BLK0.47116352
125BTK0.46401327
126CSNK2A10.46290623
127KSR10.45738736
128ITK0.44271945
129CSNK1G30.43942671
130ZAK0.43578114
131FES0.43458335
132ATM0.43381224
133CDK80.43212495
134LATS20.42032212
135BRD40.41555667
136YES10.39805433
137MAP2K30.38591624
138PAK20.38388511
139PIM10.37727883
140HCK0.37431428
141RAF10.37402213
142CDK180.37303761
143RIPK10.35962590
144MYLK0.35673992
145GRK60.35664355
146RPS6KA50.34742689
147SYK0.34660976
148PRKCI0.34408217
149CSF1R0.34198814
150FGFR10.33076396

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89899839
2Mismatch repair_Homo sapiens_hsa034303.42647443
3Spliceosome_Homo sapiens_hsa030403.30650129
4RNA polymerase_Homo sapiens_hsa030203.23225651
5Proteasome_Homo sapiens_hsa030503.20776419
6Ribosome_Homo sapiens_hsa030103.14684704
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13878483
8RNA transport_Homo sapiens_hsa030132.92457772
9Cell cycle_Homo sapiens_hsa041102.78595963
10Base excision repair_Homo sapiens_hsa034102.74364133
11Nucleotide excision repair_Homo sapiens_hsa034202.44896162
12Homologous recombination_Homo sapiens_hsa034402.33068410
13Pyrimidine metabolism_Homo sapiens_hsa002402.10309003
14Basal transcription factors_Homo sapiens_hsa030222.04673949
15Other glycan degradation_Homo sapiens_hsa005111.92611866
16mRNA surveillance pathway_Homo sapiens_hsa030151.88432733
17RNA degradation_Homo sapiens_hsa030181.79040540
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76535080
19Fanconi anemia pathway_Homo sapiens_hsa034601.74476148
20p53 signaling pathway_Homo sapiens_hsa041151.52746712
21Non-homologous end-joining_Homo sapiens_hsa034501.48185409
22Oocyte meiosis_Homo sapiens_hsa041141.45821910
23Epstein-Barr virus infection_Homo sapiens_hsa051691.45293795
24Bladder cancer_Homo sapiens_hsa052191.40011901
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32350355
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32152401
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27979782
28One carbon pool by folate_Homo sapiens_hsa006701.24463509
29Primary immunodeficiency_Homo sapiens_hsa053401.23078037
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22572911
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21927830
32Osteoclast differentiation_Homo sapiens_hsa043801.20603966
33Shigellosis_Homo sapiens_hsa051311.19496989
34Purine metabolism_Homo sapiens_hsa002301.16221140
35Fructose and mannose metabolism_Homo sapiens_hsa000511.13311797
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.12457260
37Vibrio cholerae infection_Homo sapiens_hsa051101.12211602
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.09663024
39Herpes simplex infection_Homo sapiens_hsa051681.08513897
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04498646
41HTLV-I infection_Homo sapiens_hsa051660.98961518
42Synaptic vesicle cycle_Homo sapiens_hsa047210.96893893
43Viral carcinogenesis_Homo sapiens_hsa052030.93346866
44Sulfur relay system_Homo sapiens_hsa041220.93341520
45Folate biosynthesis_Homo sapiens_hsa007900.91811914
46Renal cell carcinoma_Homo sapiens_hsa052110.90828738
47Lysosome_Homo sapiens_hsa041420.89941576
48Colorectal cancer_Homo sapiens_hsa052100.88890235
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87850264
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87336599
51Endocytosis_Homo sapiens_hsa041440.82056926
52Regulation of autophagy_Homo sapiens_hsa041400.79897825
53Legionellosis_Homo sapiens_hsa051340.78055387
54Prion diseases_Homo sapiens_hsa050200.76826780
55Antigen processing and presentation_Homo sapiens_hsa046120.76014485
56Galactose metabolism_Homo sapiens_hsa000520.73614956
57Insulin signaling pathway_Homo sapiens_hsa049100.72831314
58Tuberculosis_Homo sapiens_hsa051520.72267196
59T cell receptor signaling pathway_Homo sapiens_hsa046600.70624590
60ErbB signaling pathway_Homo sapiens_hsa040120.69528655
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67941721
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67872498
63Carbon metabolism_Homo sapiens_hsa012000.67207843
64Pentose phosphate pathway_Homo sapiens_hsa000300.66483569
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65119724
66Hematopoietic cell lineage_Homo sapiens_hsa046400.64939591
67Hepatitis C_Homo sapiens_hsa051600.64552733
68N-Glycan biosynthesis_Homo sapiens_hsa005100.64489793
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64098520
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63108407
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62514002
72Vitamin B6 metabolism_Homo sapiens_hsa007500.62033281
73Phagosome_Homo sapiens_hsa041450.61852721
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61758925
75MicroRNAs in cancer_Homo sapiens_hsa052060.61402965
76Systemic lupus erythematosus_Homo sapiens_hsa053220.60264759
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59693174
78Oxidative phosphorylation_Homo sapiens_hsa001900.59683706
79Thyroid cancer_Homo sapiens_hsa052160.58122458
80TNF signaling pathway_Homo sapiens_hsa046680.57951667
81Glioma_Homo sapiens_hsa052140.57816437
82Basal cell carcinoma_Homo sapiens_hsa052170.57777611
83Collecting duct acid secretion_Homo sapiens_hsa049660.57549043
84Chronic myeloid leukemia_Homo sapiens_hsa052200.57546780
85Apoptosis_Homo sapiens_hsa042100.56224938
86Measles_Homo sapiens_hsa051620.55785342
87Notch signaling pathway_Homo sapiens_hsa043300.54395495
88Hepatitis B_Homo sapiens_hsa051610.54348513
89Protein export_Homo sapiens_hsa030600.54324743
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.53621356
91Inositol phosphate metabolism_Homo sapiens_hsa005620.53164865
92HIF-1 signaling pathway_Homo sapiens_hsa040660.52918162
93Hippo signaling pathway_Homo sapiens_hsa043900.52897989
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51773687
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50091828
96Viral myocarditis_Homo sapiens_hsa054160.48783931
97Small cell lung cancer_Homo sapiens_hsa052220.48565125
98Huntingtons disease_Homo sapiens_hsa050160.47876964
99Biosynthesis of amino acids_Homo sapiens_hsa012300.47386703
100Salmonella infection_Homo sapiens_hsa051320.45309690
101Hedgehog signaling pathway_Homo sapiens_hsa043400.43455577
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.42991671
103Alcoholism_Homo sapiens_hsa050340.42945060
104Acute myeloid leukemia_Homo sapiens_hsa052210.42744895
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.42450706
106B cell receptor signaling pathway_Homo sapiens_hsa046620.42158515
107Leishmaniasis_Homo sapiens_hsa051400.42110578
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41285596
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.40294969
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39964125
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39473522
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39410222
113Pathways in cancer_Homo sapiens_hsa052000.38896362
114Allograft rejection_Homo sapiens_hsa053300.38599892
115Non-small cell lung cancer_Homo sapiens_hsa052230.37768244
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35814554
117VEGF signaling pathway_Homo sapiens_hsa043700.34994356
118Asthma_Homo sapiens_hsa053100.34750970
119TGF-beta signaling pathway_Homo sapiens_hsa043500.34566253
120Wnt signaling pathway_Homo sapiens_hsa043100.34465289
121Parkinsons disease_Homo sapiens_hsa050120.32982918
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32860335
123mTOR signaling pathway_Homo sapiens_hsa041500.32538400
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31449747
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30515554
126Influenza A_Homo sapiens_hsa051640.30444522
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30326591
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30105420
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29548498
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.29267485
131Pancreatic cancer_Homo sapiens_hsa052120.29148007
132Endometrial cancer_Homo sapiens_hsa052130.29045037
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28100089
134Type I diabetes mellitus_Homo sapiens_hsa049400.27531977
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.27155220
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.26869176

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