DGCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.79286700
2pyrimidine nucleobase catabolic process (GO:0006208)5.40004274
3establishment of nucleus localization (GO:0040023)5.09012231
4nucleobase catabolic process (GO:0046113)4.32229289
5negative regulation of axon guidance (GO:1902668)4.24725080
6layer formation in cerebral cortex (GO:0021819)4.18569757
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.13932458
8axon extension involved in axon guidance (GO:0048846)4.13932458
9negative regulation of erythrocyte differentiation (GO:0045647)3.97561863
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93393362
11negative regulation of axon extension involved in axon guidance (GO:0048843)3.83097459
12protein localization to endosome (GO:0036010)3.77801894
13epithelial cell differentiation involved in prostate gland development (GO:0060742)3.72412482
14Golgi transport vesicle coating (GO:0048200)3.71529596
15COPI coating of Golgi vesicle (GO:0048205)3.71529596
16embryonic foregut morphogenesis (GO:0048617)3.71118152
17negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.70895800
18negative regulation of cell size (GO:0045792)3.60587763
19negative regulation of microtubule polymerization (GO:0031115)3.56268123
20regulation of ARF protein signal transduction (GO:0032012)3.44689934
21regulation of axon guidance (GO:1902667)3.39734668
22alpha-linolenic acid metabolic process (GO:0036109)3.36247729
23macroautophagy (GO:0016236)3.35174699
24positive regulation of gastrulation (GO:2000543)3.29057072
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.28812615
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.27384639
27barbed-end actin filament capping (GO:0051016)3.26314796
28regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.25545784
29hemidesmosome assembly (GO:0031581)3.23943781
30adherens junction assembly (GO:0034333)3.21730507
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20112397
32synaptic vesicle maturation (GO:0016188)3.18632596
33locomotory exploration behavior (GO:0035641)3.12873652
34cerebellar Purkinje cell layer development (GO:0021680)3.10700219
35sodium ion export (GO:0071436)3.08784573
36positive regulation of synapse maturation (GO:0090129)3.07728146
37dendritic spine morphogenesis (GO:0060997)3.05603003
38cell-substrate junction assembly (GO:0007044)3.04836990
39regulation of axon extension involved in axon guidance (GO:0048841)3.03426041
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03206406
41cell communication by electrical coupling (GO:0010644)3.01818894
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01303987
43focal adhesion assembly (GO:0048041)3.00120705
44cell-substrate adherens junction assembly (GO:0007045)3.00120705
45desmosome organization (GO:0002934)2.96290175
46amino acid import (GO:0043090)2.94134755
47negative regulation of oligodendrocyte differentiation (GO:0048715)2.93917078
48regulation of early endosome to late endosome transport (GO:2000641)2.93136373
49dendrite morphogenesis (GO:0048813)2.90914619
50semaphorin-plexin signaling pathway (GO:0071526)2.89391629
51stress granule assembly (GO:0034063)2.88143727
52cell migration in hindbrain (GO:0021535)2.87007026
53pre-miRNA processing (GO:0031054)2.85576553
54astrocyte differentiation (GO:0048708)2.85037620
55lung epithelium development (GO:0060428)2.84384701
56dopaminergic neuron differentiation (GO:0071542)2.79924010
57regulation of extracellular matrix disassembly (GO:0010715)2.79732535
58glutamate secretion (GO:0014047)2.79480953
59cell-cell junction maintenance (GO:0045217)2.78270754
60axon extension (GO:0048675)2.76340661
61regulation of cholesterol homeostasis (GO:2000188)2.75688627
62regulation of ARF GTPase activity (GO:0032312)2.75177627
63positive regulation of receptor recycling (GO:0001921)2.72142616
64stress fiber assembly (GO:0043149)2.71518375
65apoptotic process involved in morphogenesis (GO:0060561)2.70731539
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68837783
67regulation of synapse structural plasticity (GO:0051823)2.68792943
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66905847
69activation of Rac GTPase activity (GO:0032863)2.65298651
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64306379
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63153644
72negative regulation of cell killing (GO:0031342)2.63153644
73regulation of cholesterol biosynthetic process (GO:0045540)2.62242291
74neurotransmitter secretion (GO:0007269)2.62025795
75cerebellar granule cell differentiation (GO:0021707)2.61882306
76signal complex assembly (GO:0007172)2.61647143
77cardiac muscle cell proliferation (GO:0060038)2.61100361
78midgut development (GO:0007494)2.60450675
79activation of protein kinase A activity (GO:0034199)2.59679481
80cerebellar Purkinje cell differentiation (GO:0021702)2.58142700
81peptidyl-lysine dimethylation (GO:0018027)2.58056771
82regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.57599145
83mannose metabolic process (GO:0006013)2.57381010
84protein targeting to plasma membrane (GO:0072661)2.57203447
85negative chemotaxis (GO:0050919)2.56729905
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.56522021
87response to laminar fluid shear stress (GO:0034616)2.56212381
88axonal fasciculation (GO:0007413)2.56015308
89negative regulation of catenin import into nucleus (GO:0035414)2.55401985
90L-amino acid import (GO:0043092)2.55334747
91regulation of fatty acid beta-oxidation (GO:0031998)2.55048074
92negative regulation of myotube differentiation (GO:0010832)2.54690599
93G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54653017
94negative regulation of cholesterol transport (GO:0032375)2.54643215
95negative regulation of sterol transport (GO:0032372)2.54643215
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54076405
97regulation of synaptic vesicle exocytosis (GO:2000300)2.53591787
98cellular potassium ion homeostasis (GO:0030007)2.52024231
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51213625
100gastrulation with mouth forming second (GO:0001702)2.50948748
101negative regulation of axon extension (GO:0030517)2.50598015
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50027288
103striated muscle cell proliferation (GO:0014855)2.48360537
104neuron recognition (GO:0008038)2.47471722
105spinal cord development (GO:0021510)2.47111134
106nucleus localization (GO:0051647)2.46713248
107peptidyl-arginine omega-N-methylation (GO:0035247)2.46175274
108cerebellum development (GO:0021549)2.45829891
109synaptic vesicle docking involved in exocytosis (GO:0016081)2.45281661
110establishment of planar polarity (GO:0001736)2.44832975
111establishment of tissue polarity (GO:0007164)2.44832975
112collecting duct development (GO:0072044)2.43212612
113regulation of amyloid precursor protein catabolic process (GO:1902991)2.43072327
114vocalization behavior (GO:0071625)2.41132513
115positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40052324
116antigen processing and presentation of endogenous antigen (GO:0019883)2.39977345
117epithelial cell-cell adhesion (GO:0090136)2.39437004
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38882366
119auditory behavior (GO:0031223)2.38509835
120cell differentiation in hindbrain (GO:0021533)2.38421978
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.38379496
122positive regulation of catecholamine secretion (GO:0033605)2.38322436
123activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38007458
124exploration behavior (GO:0035640)2.37675018
125alanine transport (GO:0032328)2.37406289
126ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36644552
127innervation (GO:0060384)2.36322629
128glial cell proliferation (GO:0014009)2.34458770
129basement membrane organization (GO:0071711)2.33777274
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.32746134
131lysine metabolic process (GO:0006553)2.32351343
132lysine catabolic process (GO:0006554)2.32351343
133intracellular estrogen receptor signaling pathway (GO:0030520)2.31976914
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31503189
135negative regulation of sodium ion transport (GO:0010766)2.31409411
136neuron projection extension (GO:1990138)2.30527555
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30267276
138neuronal stem cell maintenance (GO:0097150)2.30186413
139proline transport (GO:0015824)2.29756360
140synaptic vesicle exocytosis (GO:0016079)2.29324894
141response to auditory stimulus (GO:0010996)2.29152326
142regulation of chemokine-mediated signaling pathway (GO:0070099)2.28749301
143positive regulation of nuclease activity (GO:0032075)2.27335973
144maternal placenta development (GO:0001893)2.26970590
145regulation of leukocyte degranulation (GO:0043300)2.26867164
146cellular response to epidermal growth factor stimulus (GO:0071364)2.26352550
147protein retention in ER lumen (GO:0006621)2.25844642
148muscle cell proliferation (GO:0033002)2.25140373
149regulation of NFAT protein import into nucleus (GO:0051532)2.24375876
150positive regulation of glycogen biosynthetic process (GO:0045725)2.24313737
151activation of JUN kinase activity (GO:0007257)2.23666749
152modulation by virus of host morphology or physiology (GO:0019048)2.22506698
153regulation of defense response to virus by virus (GO:0050690)2.21944345
154proline biosynthetic process (GO:0006561)2.21658856
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.20778000
156positive regulation of cellular amide metabolic process (GO:0034250)2.20687732
157regulation of cholesterol metabolic process (GO:0090181)2.19149141
158regulation of water loss via skin (GO:0033561)2.17550492
159cell volume homeostasis (GO:0006884)2.16994746
160positive regulation of protein dephosphorylation (GO:0035307)2.16356292
161regulation of regulated secretory pathway (GO:1903305)2.15353041
162detection of other organism (GO:0098543)2.15247748
163neuronal ion channel clustering (GO:0045161)2.14646266
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.14482553
165embryonic process involved in female pregnancy (GO:0060136)2.13368507
166modulation by symbiont of host cellular process (GO:0044068)2.12664757
167detection of bacterium (GO:0016045)2.11651596
168regulation of cellular amide metabolic process (GO:0034248)2.11536543
169cell junction maintenance (GO:0034331)2.11408703
170modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.11111151
171positive regulation by organism of defense response of other organism involved in symbiotic interact2.11111151
172modulation by symbiont of host immune response (GO:0052553)2.11111151
173positive regulation by symbiont of host defense response (GO:0052509)2.11111151
174modulation by symbiont of host defense response (GO:0052031)2.11111151
175modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.11111151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.28933188
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.04599634
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.83767189
4VDR_21846776_ChIP-Seq_THP-1_Human2.39497968
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34326792
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32635889
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29219528
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22909077
9LXR_22292898_ChIP-Seq_THP-1_Human2.19426291
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.19271710
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14747415
12ZNF263_19887448_ChIP-Seq_K562_Human2.13225218
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12783650
14KDM2B_26808549_Chip-Seq_K562_Human2.08607379
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.08427584
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07424517
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98467813
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98467813
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97763832
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92973392
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91518513
22KDM2B_26808549_Chip-Seq_DND41_Human1.90694740
23OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.90247990
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89457111
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.88328594
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87192465
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86055406
28DROSHA_22980978_ChIP-Seq_HELA_Human1.81188789
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80942967
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80558175
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79935263
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70975929
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.69182053
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69059515
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68754462
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.68389027
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67780302
38REST_21632747_ChIP-Seq_MESCs_Mouse1.66007137
39* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65203804
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65183626
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.64621067
42MYC_22102868_ChIP-Seq_BL_Human1.63606138
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62897119
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62549619
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.62376089
46ZNF274_21170338_ChIP-Seq_K562_Hela1.62122177
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61892290
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60092537
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59636966
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57340180
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54185602
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.53029414
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51907604
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51219853
55* KDM2B_26808549_Chip-Seq_JURKAT_Human1.50798065
56CLOCK_20551151_ChIP-Seq_293T_Human1.50370937
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.49988294
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49979457
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46307186
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45152570
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.43966215
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38761999
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38141072
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37867605
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37517127
66SMC4_20622854_ChIP-Seq_HELA_Human1.37400270
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.36989043
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36901969
69CREB1_26743006_Chip-Seq_LNCaP_Human1.36241589
70VDR_24763502_ChIP-Seq_THP-1_Human1.35825985
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34233226
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32190994
73P68_20966046_ChIP-Seq_HELA_Human1.31927032
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.31899256
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.31648684
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31277865
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30841861
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30372008
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29694749
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29657670
81CTCF_27219007_Chip-Seq_Bcells_Human1.29361058
82* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28821463
83TCF7_22412390_ChIP-Seq_EML_Mouse1.26425110
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25449985
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.23842022
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.23600109
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22215292
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.20282360
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.19839364
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19723400
91RACK7_27058665_Chip-Seq_MCF-7_Human1.19463277
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18784233
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.18716951
94* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18395571
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.17557531
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.17393301
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17302917
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16530937
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15944807
100MAF_26560356_Chip-Seq_TH1_Human1.15250728
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15117801
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13609455
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12631944
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.12053972
105UTX_26944678_Chip-Seq_JUKART_Human1.11941537
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11757269
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11124327
108* NCOR1_26117541_ChIP-Seq_K562_Human1.10181533
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.09881515
110* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08514971
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.08053433
112* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.07656545
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04394386
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04207857
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04033313
116BCOR_27268052_Chip-Seq_Bcells_Human1.03868420
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03323976
118* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02852687
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01831762
120GATA1_19941826_ChIP-Seq_K562_Human1.01775649
121BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01573530
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.01372589
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01059143
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01041668
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00940775
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00837396
127MAF_26560356_Chip-Seq_TH2_Human1.00682589
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00537987
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99571384
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.99350936
131TP53_22127205_ChIP-Seq_IMR90_Human0.98936894
132KLF4_19829295_ChIP-Seq_ESCs_Human0.97569409
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97533904
134* SPI1_23127762_ChIP-Seq_K562_Human0.97326879
135* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97288369
136* AR_19668381_ChIP-Seq_PC3_Human0.97149872
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97085172
138* TP63_22573176_ChIP-Seq_HFKS_Human0.97074554
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96969700
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.96863368
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.96863368
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96647209
143JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96562713
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.95594596
145MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95086344
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93445234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.90799685
2MP0003283_abnormal_digestive_organ3.63234492
3MP0004859_abnormal_synaptic_plasticity3.52884385
4MP0008961_abnormal_basal_metabolism2.98737700
5MP0008260_abnormal_autophagy2.94543031
6MP0005058_abnormal_lysosome_morphology2.61082646
7MP0003566_abnormal_cell_adhesion2.55016751
8MP0000537_abnormal_urethra_morphology2.51721717
9MP0005409_darkened_coat_color2.51124668
10MP0005451_abnormal_body_composition2.29072356
11MP0002234_abnormal_pharynx_morphology2.25630266
12MP0009780_abnormal_chondrocyte_physiolo2.24146770
13MP0002653_abnormal_ependyma_morphology2.24069841
14MP0002139_abnormal_hepatobiliary_system2.22617056
15MP0003191_abnormal_cellular_cholesterol2.22240500
16MP0009053_abnormal_anal_canal2.17472044
17MP0003705_abnormal_hypodermis_morpholog2.16729298
18MP0003172_abnormal_lysosome_physiology2.10853850
19MP0000579_abnormal_nail_morphology2.07078360
20MP0001958_emphysema2.03213291
21MP0003300_gastrointestinal_ulcer2.00633997
22MP0003635_abnormal_synaptic_transmissio2.00616563
23MP0004858_abnormal_nervous_system1.98543046
24MP0002796_impaired_skin_barrier1.97173160
25MP0000778_abnormal_nervous_system1.95546660
26MP0003690_abnormal_glial_cell1.95455966
27MP0010030_abnormal_orbit_morphology1.93700069
28MP0009278_abnormal_bone_marrow1.92719600
29MP0000678_abnormal_parathyroid_gland1.92349228
30MP0003453_abnormal_keratinocyte_physiol1.87689173
31MP0003115_abnormal_respiratory_system1.87009886
32MP0003303_peritoneal_inflammation1.85515586
33MP0002909_abnormal_adrenal_gland1.83704456
34MP0003119_abnormal_digestive_system1.81748858
35MP0008438_abnormal_cutaneous_collagen1.78567305
36MP0000534_abnormal_ureter_morphology1.73819062
37MP0003329_amyloid_beta_deposits1.72630461
38MP0000569_abnormal_digit_pigmentation1.69296518
39MP0003436_decreased_susceptibility_to1.69295762
40MP0000462_abnormal_digestive_system1.67857994
41MP0003121_genomic_imprinting1.67082593
42MP0003091_abnormal_cell_migration1.63391754
43MP0005083_abnormal_biliary_tract1.63019963
44MP0003890_abnormal_embryonic-extraembry1.58606015
45MP0004233_abnormal_muscle_weight1.57663766
46MP0004947_skin_inflammation1.55828214
47MP0000955_abnormal_spinal_cord1.55324327
48MP0005365_abnormal_bile_salt1.54856417
49MP0003942_abnormal_urinary_system1.53312949
50MP0009840_abnormal_foam_cell1.53089882
51MP0001849_ear_inflammation1.51925603
52MP0002063_abnormal_learning/memory/cond1.51319242
53MP0005187_abnormal_penis_morphology1.50970546
54MP0000566_synostosis1.48367348
55MP0005360_urolithiasis1.48280616
56MP0003075_altered_response_to1.47761453
57MP0004811_abnormal_neuron_physiology1.45723222
58MP0003634_abnormal_glial_cell1.41659042
59MP0006276_abnormal_autonomic_nervous1.40116144
60MP0005645_abnormal_hypothalamus_physiol1.35072255
61MP0005085_abnormal_gallbladder_physiolo1.34917836
62MP0004270_analgesia1.34456798
63MP0000604_amyloidosis1.33646148
64MP0002184_abnormal_innervation1.33490163
65MP0004381_abnormal_hair_follicle1.29743621
66MP0004272_abnormal_basement_membrane1.29592393
67MP0002060_abnormal_skin_morphology1.28477419
68MP0005501_abnormal_skin_physiology1.27739136
69MP0003879_abnormal_hair_cell1.27298250
70MP0005275_abnormal_skin_tensile1.27270111
71MP0003861_abnormal_nervous_system1.23961362
72MP0002557_abnormal_social/conspecific_i1.23411830
73MP0000467_abnormal_esophagus_morphology1.22962052
74MP0002089_abnormal_postnatal_growth/wei1.22453546
75MP0010329_abnormal_lipoprotein_level1.21227229
76MP0000920_abnormal_myelination1.20717874
77MP0004133_heterotaxia1.16049099
78MP0010234_abnormal_vibrissa_follicle1.13844300
79MP0003279_aneurysm1.13197531
80MP0001968_abnormal_touch/_nociception1.11167156
81MP0002152_abnormal_brain_morphology1.10664455
82MP0001270_distended_abdomen1.10633321
83MP0000858_altered_metastatic_potential1.10151705
84MP0001348_abnormal_lacrimal_gland1.09487838
85MP0005394_taste/olfaction_phenotype1.08435733
86MP0005499_abnormal_olfactory_system1.08435733
87MP0000751_myopathy1.07900641
88MP0002064_seizures1.07457713
89MP0003123_paternal_imprinting1.07109220
90MP0002098_abnormal_vibrissa_morphology1.06373234
91MP0002282_abnormal_trachea_morphology1.06348276
92MP0005220_abnormal_exocrine_pancreas1.05544700
93MP0001666_abnormal_nutrient_absorption1.05419016
94MP0003724_increased_susceptibility_to1.03800535
95MP0006054_spinal_hemorrhage1.02229295
96MP0003385_abnormal_body_wall1.01817071
97MP0008995_early_reproductive_senescence1.01604454
98MP0003183_abnormal_peptide_metabolism0.99942974
99MP0005076_abnormal_cell_differentiation0.99811113
100MP0005023_abnormal_wound_healing0.98915735
101MP0003959_abnormal_lean_body0.98385877
102MP0004185_abnormal_adipocyte_glucose0.97186223
103MP0001851_eye_inflammation0.96018228
104MP0004264_abnormal_extraembryonic_tissu0.95175614
105MP0005257_abnormal_intraocular_pressure0.94221277
106MP0001533_abnormal_skeleton_physiology0.93281627
107MP0005666_abnormal_adipose_tissue0.92621038
108MP0001944_abnormal_pancreas_morphology0.92242495
109MP0005623_abnormal_meninges_morphology0.91525561
110MP0002837_dystrophic_cardiac_calcinosis0.89532197
111MP0000465_gastrointestinal_hemorrhage0.89327790
112MP0004510_myositis0.89208042
113MP0002882_abnormal_neuron_morphology0.89072217
114MP0010386_abnormal_urinary_bladder0.88548102
115MP0003868_abnormal_feces_composition0.87780630
116MP0001664_abnormal_digestion0.87187078
117MP0005670_abnormal_white_adipose0.86866177
118MP0002572_abnormal_emotion/affect_behav0.86700234
119MP0000538_abnormal_urinary_bladder0.86167159
120MP0002896_abnormal_bone_mineralization0.85867220
121MP0002998_abnormal_bone_remodeling0.85718655
122MP0009745_abnormal_behavioral_response0.85614372
123MP0005621_abnormal_cell_physiology0.84000750
124MP0005375_adipose_tissue_phenotype0.83919272
125MP0005166_decreased_susceptibility_to0.83810772
126MP0002736_abnormal_nociception_after0.83324558
127MP0002932_abnormal_joint_morphology0.83278508
128MP0008874_decreased_physiological_sensi0.83074396
129MP0004885_abnormal_endolymph0.82150593
130MP0000377_abnormal_hair_follicle0.81759481
131MP0005464_abnormal_platelet_physiology0.81488725
132MP0004782_abnormal_surfactant_physiolog0.81324942
133MP0009931_abnormal_skin_appearance0.80997648
134MP0001216_abnormal_epidermal_layer0.80537436
135MP0001529_abnormal_vocalization0.79771456
136MP0000013_abnormal_adipose_tissue0.79756664
137MP0000747_muscle_weakness0.79684872
138MP0000681_abnormal_thyroid_gland0.79022620
139MP0005423_abnormal_somatic_nervous0.78969497
140MP0008569_lethality_at_weaning0.78519346
141MP0002877_abnormal_melanocyte_morpholog0.78254922
142MP0002116_abnormal_craniofacial_bone0.77992986
143MP0010771_integument_phenotype0.77784032
144MP0000003_abnormal_adipose_tissue0.77707988
145MP0002733_abnormal_thermal_nociception0.76839713
146MP0002734_abnormal_mechanical_nocicepti0.76825132
147MP0002081_perinatal_lethality0.76386433
148MP0002249_abnormal_larynx_morphology0.76373898
149MP0001915_intracranial_hemorrhage0.75907473
150MP0004924_abnormal_behavior0.75855162
151MP0005386_behavior/neurological_phenoty0.75855162
152MP0002084_abnormal_developmental_patter0.75699871
153MP0002133_abnormal_respiratory_system0.75235545
154MP0005388_respiratory_system_phenotype0.75235545
155MP0002419_abnormal_innate_immunity0.75073531
156MP0004197_abnormal_fetal_growth/weight/0.74600629
157MP0004130_abnormal_muscle_cell0.74476208
158MP0002069_abnormal_eating/drinking_beha0.74146802
159MP0001502_abnormal_circadian_rhythm0.72144297
160MP0002735_abnormal_chemical_nociception0.72141375
161MP0000762_abnormal_tongue_morphology0.71844987
162MP0003828_pulmonary_edema0.71189618
163MP0002233_abnormal_nose_morphology0.70593385
164MP0000631_abnormal_neuroendocrine_gland0.69859538
165MP0000049_abnormal_middle_ear0.69789444
166MP0002067_abnormal_sensory_capabilities0.69282050
167MP0002066_abnormal_motor_capabilities/c0.68853418
168MP0001299_abnormal_eye_distance/0.68519409
169MP0009672_abnormal_birth_weight0.68109997
170MP0008004_abnormal_stomach_pH0.67778689
171MP0010630_abnormal_cardiac_muscle0.66895164
172MP0005025_abnormal_response_to0.64017126
173MP0000767_abnormal_smooth_muscle0.63918735
174MP0005390_skeleton_phenotype0.62989606
175MP0009384_cardiac_valve_regurgitation0.62827392

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.50999863
2Insomnia (HP:0100785)3.72563823
3Renal duplication (HP:0000075)3.55352795
4Obstructive sleep apnea (HP:0002870)3.46947379
5Abnormality of the lower motor neuron (HP:0002366)3.43046211
6Elfin facies (HP:0004428)3.38551763
7Renovascular hypertension (HP:0100817)3.22926721
8Neoplasm of the heart (HP:0100544)3.02879058
9Overriding aorta (HP:0002623)2.96912671
10Lymphangioma (HP:0100764)2.94853781
11Neurofibrillary tangles (HP:0002185)2.89851018
12Bowel diverticulosis (HP:0005222)2.84587644
13Eczematoid dermatitis (HP:0000976)2.81270256
14Failure to thrive in infancy (HP:0001531)2.76190047
15Broad face (HP:0000283)2.74397528
16Ependymoma (HP:0002888)2.67325141
17Bladder diverticulum (HP:0000015)2.63778356
18Pointed chin (HP:0000307)2.62612832
19Visual hallucinations (HP:0002367)2.57007323
20Abnormality of the astrocytes (HP:0100707)2.56948818
21Astrocytoma (HP:0009592)2.56948818
22Hepatoblastoma (HP:0002884)2.53777547
23Hypoventilation (HP:0002791)2.53343634
24Protrusio acetabuli (HP:0003179)2.53225100
25Hallux valgus (HP:0001822)2.49509635
26Aortic aneurysm (HP:0004942)2.48033162
27Deep venous thrombosis (HP:0002625)2.47397528
28Cerebral aneurysm (HP:0004944)2.45575946
29Deviation of the hallux (HP:0010051)2.42606412
30Back pain (HP:0003418)2.41783598
31Limb-girdle muscle atrophy (HP:0003797)2.38157722
32Ankyloglossia (HP:0010296)2.36926179
33Turricephaly (HP:0000262)2.33981336
34Atrophic scars (HP:0001075)2.33601609
35Ulnar bowing (HP:0003031)2.33039375
36Hand muscle atrophy (HP:0009130)2.32413941
37Flat cornea (HP:0007720)2.31557130
38Increased connective tissue (HP:0009025)2.28981494
39Bronchomalacia (HP:0002780)2.28231510
40Short 4th metacarpal (HP:0010044)2.25544118
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25544118
42Peripheral hypomyelination (HP:0007182)2.24804060
43Shallow orbits (HP:0000586)2.23736283
44Supranuclear gaze palsy (HP:0000605)2.21927545
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.19690548
46Distal lower limb amyotrophy (HP:0008944)2.19412045
47Premature rupture of membranes (HP:0001788)2.18973147
48Cellulitis (HP:0100658)2.18414315
49Fragile skin (HP:0001030)2.16782161
50Increased variability in muscle fiber diameter (HP:0003557)2.14648683
51Macroorchidism (HP:0000053)2.13694133
52Depression (HP:0000716)2.13628999
53Megalocornea (HP:0000485)2.12962618
54Abnormality of the 4th metacarpal (HP:0010012)2.12764976
55Shoulder girdle muscle weakness (HP:0003547)2.11429494
56Bowel incontinence (HP:0002607)2.10881749
57Amyotrophic lateral sclerosis (HP:0007354)2.09599114
58Upper limb amyotrophy (HP:0009129)2.08402554
59Distal upper limb amyotrophy (HP:0007149)2.08402554
60Polyphagia (HP:0002591)2.07669393
61Neuronal loss in central nervous system (HP:0002529)2.06585491
62Aneurysm (HP:0002617)2.04951097
63Vertebral compression fractures (HP:0002953)2.04509742
64Abnormality of the diencephalon (HP:0010662)2.03732192
65Increased IgE level (HP:0003212)2.03216937
66Interstitial pulmonary disease (HP:0006530)2.00223209
67Disproportionate tall stature (HP:0001519)1.98992077
68Ankle clonus (HP:0011448)1.97896648
69Stridor (HP:0010307)1.96903388
70Truncus arteriosus (HP:0001660)1.96817726
71Mitral regurgitation (HP:0001653)1.94883061
72Myokymia (HP:0002411)1.94769793
73Long palpebral fissure (HP:0000637)1.93295672
74Distal lower limb muscle weakness (HP:0009053)1.93120067
75Exotropia (HP:0000577)1.92484922
76Abnormal large intestine physiology (HP:0012700)1.92364877
77Hemorrhage of the eye (HP:0011885)1.91669599
78Abnormality of oral frenula (HP:0000190)1.91270960
79Lower limb amyotrophy (HP:0007210)1.90069625
80Cerebral inclusion bodies (HP:0100314)1.89294376
81Cervical subluxation (HP:0003308)1.87562725
82Apathy (HP:0000741)1.87105832
83Gingivitis (HP:0000230)1.86967064
84Arterial tortuosity (HP:0005116)1.86050014
85Hypoplastic toenails (HP:0001800)1.85471237
86Colon cancer (HP:0003003)1.85426371
87Thin bony cortex (HP:0002753)1.84988655
88Torticollis (HP:0000473)1.81409250
89Abnormality of skeletal muscle fiber size (HP:0012084)1.81023396
90Annular pancreas (HP:0001734)1.80789937
91Abnormal eating behavior (HP:0100738)1.80353507
92Anosmia (HP:0000458)1.79703941
93Abnormal social behavior (HP:0012433)1.79595980
94Impaired social interactions (HP:0000735)1.79595980
95Dilatation of the ascending aorta (HP:0005111)1.78652204
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78153991
97Onion bulb formation (HP:0003383)1.77372526
98Obsessive-compulsive behavior (HP:0000722)1.77245344
99Focal seizures (HP:0007359)1.77021728
100Athetosis (HP:0002305)1.76866816
101Sacral dimple (HP:0000960)1.75763549
102Metaphyseal cupping (HP:0003021)1.75072499
103Hyperparathyroidism (HP:0000843)1.75047590
104Fibroma (HP:0010614)1.75043400
105Flat acetabular roof (HP:0003180)1.74995139
106Germ cell neoplasia (HP:0100728)1.74353345
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.74237544
108Precocious puberty (HP:0000826)1.73422396
109Atelectasis (HP:0100750)1.73379794
110Deep palmar crease (HP:0006191)1.73032500
111Glioma (HP:0009733)1.72915974
112Hypoplasia of the brainstem (HP:0002365)1.72321969
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72321969
114Hypercortisolism (HP:0001578)1.72096180
115Pelvic girdle muscle weakness (HP:0003749)1.72037180
116Lissencephaly (HP:0001339)1.72024496
117Hammertoe (HP:0001765)1.71969769
118Growth hormone excess (HP:0000845)1.71580786
119Ketoacidosis (HP:0001993)1.71435152
120Impaired pain sensation (HP:0007328)1.70821586
121Abnormality of pain sensation (HP:0010832)1.70821586
122Striae distensae (HP:0001065)1.70210644
123Polygenic inheritance (HP:0010982)1.70192354
124Segmental peripheral demyelination/remyelination (HP:0003481)1.69540658
125Abnormality of the Achilles tendon (HP:0005109)1.69512136
126Diminished motivation (HP:0000745)1.68657558
127Open mouth (HP:0000194)1.67922167
128Focal dystonia (HP:0004373)1.67579678
129Decreased motor nerve conduction velocity (HP:0003431)1.67507662
130Rapidly progressive (HP:0003678)1.66843603
131Spastic gait (HP:0002064)1.66820534
132Poor eye contact (HP:0000817)1.66762591
133Arnold-Chiari malformation (HP:0002308)1.66624323
134Hyperthyroidism (HP:0000836)1.66207861
135Advanced eruption of teeth (HP:0006288)1.65951389
136Labial hypoplasia (HP:0000066)1.65860716
137Congenital glaucoma (HP:0001087)1.65699771
138Dysostosis multiplex (HP:0000943)1.65567175
139Aplasia involving bones of the upper limbs (HP:0009823)1.65393797
140Aplasia of the phalanges of the hand (HP:0009802)1.65393797
141Aplasia involving bones of the extremities (HP:0009825)1.65393797
142Tented upper lip vermilion (HP:0010804)1.64677517
143Difficulty running (HP:0009046)1.62908363
144Buphthalmos (HP:0000557)1.62769188
145Milia (HP:0001056)1.62129839
146Agitation (HP:0000713)1.61781786
147Broad metatarsal (HP:0001783)1.61702456
148Patellar dislocation (HP:0002999)1.61515546
149Blue sclerae (HP:0000592)1.61262520
150Difficulty climbing stairs (HP:0003551)1.61084720
151Gout (HP:0001997)1.61001375
152Abnormality of macrophages (HP:0004311)1.60948824
153Trigonocephaly (HP:0000243)1.60937265
154Fibrous tissue neoplasm (HP:0012316)1.60823402
155Craniofacial dystonia (HP:0012179)1.60299225
156Achilles tendon contracture (HP:0001771)1.60196714
157Urinary urgency (HP:0000012)1.60071328
158Distal sensory impairment (HP:0002936)1.59846076
159Cortical dysplasia (HP:0002539)1.59683474
160Abnormal gallbladder physiology (HP:0012438)1.59662381
161Cholecystitis (HP:0001082)1.59662381
162Death in childhood (HP:0003819)1.59647836
163Foot dorsiflexor weakness (HP:0009027)1.59609601
164Biconcave vertebral bodies (HP:0004586)1.59462086
165Spastic diplegia (HP:0001264)1.58994990
166Vascular tortuosity (HP:0004948)1.58961776
167Mildly elevated creatine phosphokinase (HP:0008180)1.58336193
168Amyloidosis (HP:0011034)1.57571185
169Loss of speech (HP:0002371)1.56267441
170Wormian bones (HP:0002645)1.56096831
171Right ventricular cardiomyopathy (HP:0011663)1.53407601
172Premature skin wrinkling (HP:0100678)1.51515165
173Abnormality of nail color (HP:0100643)1.50458076
174Reticulocytosis (HP:0001923)1.49878038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.45769322
2PRPF4B3.10199763
3ICK2.79899949
4PKN22.68530330
5TYRO32.64558458
6SMG12.62390630
7FGFR22.45532419
8PDGFRA2.40139103
9MAP3K102.37910133
10MARK12.37175775
11NTRK22.23568043
12EEF2K2.14998033
13MINK12.14233844
14KSR12.13618441
15ERN12.08937840
16MAP3K42.06321864
17FGFR42.04918900
18PRKD32.04032575
19EPHB12.00072404
20MAP2K41.95863910
21MAP3K91.86940410
22PTK61.86195085
23EPHA21.81341569
24PASK1.78111086
25SIK11.75995273
26RIPK11.73607951
27SIK31.72170869
28RIPK41.58414078
29RET1.54964627
30PAK61.48865777
31PRKD21.47331041
32MAP3K111.44921318
33EPHB21.35852457
34MAP3K21.35819725
35UHMK11.34883171
36MAP2K31.31660217
37ARAF1.29409988
38LMTK21.29301396
39TAOK11.29212089
40DDR21.26167542
41LATS21.21574793
42FER1.20596118
43CAMKK11.18866168
44TNK21.16527808
45DAPK21.15363235
46TESK21.12206196
47FGFR11.11511049
48CDK121.10098018
49MAP3K131.09022185
50NTRK11.08816429
51ERBB21.08382744
52NTRK31.07367414
53CAMK1G1.07198290
54STK381.02002887
55EPHA41.00270871
56BMX0.97933827
57TGFBR10.97286568
58PDPK10.97120573
59MAP3K60.96865290
60TAOK20.96311290
61MAP3K70.96306710
62SCYL20.95554406
63PAK30.93718283
64FES0.92977585
65BCR0.92764688
66MAP4K10.92570290
67MTOR0.89836836
68KSR20.89534695
69TYK20.86440953
70PTK20.84202073
71CDC42BPA0.83970801
72MST1R0.83581664
73IRAK30.81861657
74ERBB30.81044887
75CDK180.79880263
76PAK40.77769406
77NEK10.76498423
78ALK0.75543675
79GRK60.74315862
80FGFR30.74148498
81MATK0.73234419
82BCKDK0.71882241
83IRAK20.71418697
84IRAK40.71032986
85CDK50.70984202
86MARK20.69386195
87CDK150.68681678
88RPS6KL10.66132744
89RPS6KC10.66132744
90ZAP700.66115725
91TESK10.65859749
92CAMK1D0.65450356
93CDK140.65406860
94DYRK20.64757981
95SGK30.63988959
96MAPK120.63046408
97RAF10.62192612
98PDK10.60637010
99PAK20.59742110
100CDK11A0.59675834
101MELK0.58211444
102EPHA30.56913484
103DYRK1B0.55452339
104HIPK20.54391914
105HCK0.54366605
106JAK20.53975448
107MAP2K20.53966483
108MAP2K60.53755195
109PHKG10.53450714
110PHKG20.53450714
111RPS6KA20.53242561
112BRD40.53219979
113MAP3K30.52622229
114CSK0.52443822
115TTN0.51928949
116PRKD10.51486570
117PRKCZ0.51245736
118JAK10.50600817
119LRRK20.50446380
120DAPK10.49202223
121SGK2230.48717909
122SGK4940.48717909
123PDGFRB0.48639369
124FYN0.47820315
125WNK30.46829932
126PRKG20.46568611
127CDK90.45068153
128PRKCH0.44892831
129SIK20.43560582
130LIMK10.41953454
131FGR0.41544992
132BRAF0.41517201
133MAP2K10.41230479
134MAPK90.40932230
135MAP3K10.40751270
136AKT20.40625989
137RPS6KA60.40370886
138MAPK100.39978488
139ROCK20.39481539
140BRSK10.38493082
141NEK60.37748993
142CSNK1A1L0.36709379
143CSNK1G30.35771727
144SRC0.34767501
145CSNK1G20.33733710
146CSNK1E0.31887170

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.67567819
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26572894
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.06561840
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88969246
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86820166
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71582237
7Basal cell carcinoma_Homo sapiens_hsa052171.71507561
8Butanoate metabolism_Homo sapiens_hsa006501.69731726
9Other glycan degradation_Homo sapiens_hsa005111.68372054
10Notch signaling pathway_Homo sapiens_hsa043301.67242790
11Acute myeloid leukemia_Homo sapiens_hsa052211.65573827
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56255914
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53818734
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52570380
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52537661
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52473115
17Arginine biosynthesis_Homo sapiens_hsa002201.49414940
18Insulin secretion_Homo sapiens_hsa049111.49246139
19Lysine degradation_Homo sapiens_hsa003101.48284784
20Axon guidance_Homo sapiens_hsa043601.47008441
21Bile secretion_Homo sapiens_hsa049761.44388520
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35475383
23Fatty acid degradation_Homo sapiens_hsa000711.34981185
24Gap junction_Homo sapiens_hsa045401.33182743
25Synaptic vesicle cycle_Homo sapiens_hsa047211.31163705
26GABAergic synapse_Homo sapiens_hsa047271.30663185
27Tryptophan metabolism_Homo sapiens_hsa003801.29079862
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27596891
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26348330
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26330178
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.26327385
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.26070829
33Cocaine addiction_Homo sapiens_hsa050301.25594949
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24889632
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23550258
36Nicotine addiction_Homo sapiens_hsa050331.22817356
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20175845
38Fatty acid metabolism_Homo sapiens_hsa012121.18479417
39Renal cell carcinoma_Homo sapiens_hsa052111.17823695
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.17671988
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17454059
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.17342285
43Dopaminergic synapse_Homo sapiens_hsa047281.16945320
44Circadian entrainment_Homo sapiens_hsa047131.16137272
45Hippo signaling pathway_Homo sapiens_hsa043901.14790277
46Pancreatic cancer_Homo sapiens_hsa052121.14580297
47Choline metabolism in cancer_Homo sapiens_hsa052311.13986048
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.13887537
49Hedgehog signaling pathway_Homo sapiens_hsa043401.13829549
50Estrogen signaling pathway_Homo sapiens_hsa049151.10922716
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10654257
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08849834
53Melanogenesis_Homo sapiens_hsa049161.07770534
54Endocytosis_Homo sapiens_hsa041441.07525760
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07479687
56B cell receptor signaling pathway_Homo sapiens_hsa046621.07287142
57Osteoclast differentiation_Homo sapiens_hsa043801.05399941
58Focal adhesion_Homo sapiens_hsa045101.05360101
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03481378
60Amoebiasis_Homo sapiens_hsa051461.02265620
61Inositol phosphate metabolism_Homo sapiens_hsa005621.02250318
62mTOR signaling pathway_Homo sapiens_hsa041501.00906547
63Long-term potentiation_Homo sapiens_hsa047201.00480699
64Colorectal cancer_Homo sapiens_hsa052101.00445030
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.99772186
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99609086
67Thyroid cancer_Homo sapiens_hsa052160.99385688
68Glutamatergic synapse_Homo sapiens_hsa047240.98076178
69N-Glycan biosynthesis_Homo sapiens_hsa005100.96054121
70Endometrial cancer_Homo sapiens_hsa052130.94762380
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.94405901
72Type II diabetes mellitus_Homo sapiens_hsa049300.93366721
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93059929
74Biosynthesis of amino acids_Homo sapiens_hsa012300.92621859
75Fat digestion and absorption_Homo sapiens_hsa049750.91511859
76Amphetamine addiction_Homo sapiens_hsa050310.91022460
77Adherens junction_Homo sapiens_hsa045200.90991247
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.90512799
79Salivary secretion_Homo sapiens_hsa049700.89599719
80GnRH signaling pathway_Homo sapiens_hsa049120.89573717
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89380089
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89323646
83Rap1 signaling pathway_Homo sapiens_hsa040150.88341187
84Glioma_Homo sapiens_hsa052140.87398447
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86153633
86AMPK signaling pathway_Homo sapiens_hsa041520.85810758
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85776708
88Gastric acid secretion_Homo sapiens_hsa049710.85438163
89Hepatitis C_Homo sapiens_hsa051600.84910256
90Propanoate metabolism_Homo sapiens_hsa006400.83965904
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83926497
92Glucagon signaling pathway_Homo sapiens_hsa049220.83573315
93Wnt signaling pathway_Homo sapiens_hsa043100.82818911
94ECM-receptor interaction_Homo sapiens_hsa045120.81442880
95Fructose and mannose metabolism_Homo sapiens_hsa000510.81215445
96Insulin signaling pathway_Homo sapiens_hsa049100.80842714
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80426527
98ErbB signaling pathway_Homo sapiens_hsa040120.79163511
99Prion diseases_Homo sapiens_hsa050200.79036243
100Pentose phosphate pathway_Homo sapiens_hsa000300.78620053
101Prolactin signaling pathway_Homo sapiens_hsa049170.78438267
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78420024
103Thyroid hormone synthesis_Homo sapiens_hsa049180.78226147
104Chronic myeloid leukemia_Homo sapiens_hsa052200.77293840
105PPAR signaling pathway_Homo sapiens_hsa033200.75476885
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75289358
107Olfactory transduction_Homo sapiens_hsa047400.74617823
108Galactose metabolism_Homo sapiens_hsa000520.74548806
109Selenocompound metabolism_Homo sapiens_hsa004500.73486642
110Cholinergic synapse_Homo sapiens_hsa047250.73460015
111Salmonella infection_Homo sapiens_hsa051320.72872678
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72810988
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72165544
114Proteoglycans in cancer_Homo sapiens_hsa052050.71563836
115Shigellosis_Homo sapiens_hsa051310.70243633
116Platelet activation_Homo sapiens_hsa046110.70022904
117Carbon metabolism_Homo sapiens_hsa012000.69984751
118Renin secretion_Homo sapiens_hsa049240.69919078
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69817434
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69292324
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69287248
122Insulin resistance_Homo sapiens_hsa049310.68686460
123VEGF signaling pathway_Homo sapiens_hsa043700.68515935
124Pancreatic secretion_Homo sapiens_hsa049720.68439771
125Oocyte meiosis_Homo sapiens_hsa041140.68115868
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.67664708
127Chemokine signaling pathway_Homo sapiens_hsa040620.67177756
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67090348
129Lysosome_Homo sapiens_hsa041420.64884837
130Bladder cancer_Homo sapiens_hsa052190.64860580
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64668149
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63921468
133Non-small cell lung cancer_Homo sapiens_hsa052230.63199950
134Long-term depression_Homo sapiens_hsa047300.62735425
135Morphine addiction_Homo sapiens_hsa050320.62292867
136Toxoplasmosis_Homo sapiens_hsa051450.60609579
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59821434
138HIF-1 signaling pathway_Homo sapiens_hsa040660.59116597
139Dorso-ventral axis formation_Homo sapiens_hsa043200.58689716
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58127883
141Pyruvate metabolism_Homo sapiens_hsa006200.58098917
142Protein digestion and absorption_Homo sapiens_hsa049740.57832601
143Fatty acid biosynthesis_Homo sapiens_hsa000610.57799395
144Prostate cancer_Homo sapiens_hsa052150.56470279
145Tuberculosis_Homo sapiens_hsa051520.56344897
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55955286
147Vibrio cholerae infection_Homo sapiens_hsa051100.55564990
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55001442
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54596015
150Apoptosis_Homo sapiens_hsa042100.54153757
151Leishmaniasis_Homo sapiens_hsa051400.53810797
152Tight junction_Homo sapiens_hsa045300.53736251
153Hepatitis B_Homo sapiens_hsa051610.53413128

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