DGCR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.64536126
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.98795332
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83390701
4glutamate secretion (GO:0014047)5.74069420
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.29502898
6synaptic vesicle exocytosis (GO:0016079)5.11866380
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81424531
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80561694
9regulation of synaptic vesicle exocytosis (GO:2000300)4.79372862
10neurotransmitter secretion (GO:0007269)4.64402529
11gamma-aminobutyric acid transport (GO:0015812)4.61294671
12neuronal action potential propagation (GO:0019227)4.46255690
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.45466583
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.42543383
15regulation of synaptic vesicle transport (GO:1902803)4.41500936
16synaptic transmission, glutamatergic (GO:0035249)4.27051732
17postsynaptic membrane organization (GO:0001941)4.19280648
18vocalization behavior (GO:0071625)4.10071222
19regulation of synapse structural plasticity (GO:0051823)4.03146627
20protein localization to synapse (GO:0035418)4.01014905
21glutamate receptor signaling pathway (GO:0007215)4.00990243
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.98218628
23dendritic spine morphogenesis (GO:0060997)3.94497560
24neurotransmitter transport (GO:0006836)3.80497788
25locomotory exploration behavior (GO:0035641)3.79480842
26cellular potassium ion homeostasis (GO:0030007)3.79235641
27neuron-neuron synaptic transmission (GO:0007270)3.79131352
28neuron cell-cell adhesion (GO:0007158)3.72647427
29neuromuscular process controlling posture (GO:0050884)3.70754892
30regulation of neuronal synaptic plasticity (GO:0048168)3.68771365
31serotonin metabolic process (GO:0042428)3.66033780
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65956490
33neurotransmitter-gated ion channel clustering (GO:0072578)3.63361581
34membrane depolarization during action potential (GO:0086010)3.62511215
35regulation of neurotransmitter levels (GO:0001505)3.58990115
36behavioral response to nicotine (GO:0035095)3.57643779
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.54403637
38presynaptic membrane assembly (GO:0097105)3.54153782
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53272507
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50103943
41primary amino compound metabolic process (GO:1901160)3.49629642
42regulation of neurotransmitter secretion (GO:0046928)3.49467932
43proline transport (GO:0015824)3.47838702
44transmission of nerve impulse (GO:0019226)3.47328721
45exploration behavior (GO:0035640)3.45495866
46regulation of postsynaptic membrane potential (GO:0060078)3.41875249
47auditory behavior (GO:0031223)3.38085594
48regulation of glutamate receptor signaling pathway (GO:1900449)3.37080040
49presynaptic membrane organization (GO:0097090)3.36916540
50regulation of neurotransmitter transport (GO:0051588)3.35308029
51positive regulation of membrane potential (GO:0045838)3.33161207
52positive regulation of dendritic spine development (GO:0060999)3.30425873
53startle response (GO:0001964)3.30078232
54regulation of dendritic spine morphogenesis (GO:0061001)3.29907578
55neuromuscular synaptic transmission (GO:0007274)3.29445798
56positive regulation of synapse maturation (GO:0090129)3.28866046
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.28251617
58regulation of voltage-gated calcium channel activity (GO:1901385)3.28070668
59central nervous system myelination (GO:0022010)3.27852708
60axon ensheathment in central nervous system (GO:0032291)3.27852708
61synaptic vesicle endocytosis (GO:0048488)3.24631326
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24331438
63membrane depolarization (GO:0051899)3.21545220
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.20064016
65regulation of dendritic spine development (GO:0060998)3.15752755
66positive regulation of neurotransmitter secretion (GO:0001956)3.08137646
67cerebellar granule cell differentiation (GO:0021707)3.07423907
68positive regulation of neurotransmitter transport (GO:0051590)3.07282134
69cerebellar Purkinje cell differentiation (GO:0021702)3.06475483
70synaptic transmission (GO:0007268)3.05585156
71potassium ion import (GO:0010107)3.04616905
72regulation of calcium ion-dependent exocytosis (GO:0017158)2.98082630
73behavioral defense response (GO:0002209)2.97512532
74behavioral fear response (GO:0001662)2.97512532
75L-amino acid import (GO:0043092)2.91373199
76pyrimidine nucleobase catabolic process (GO:0006208)2.89927632
77calcium ion-dependent exocytosis (GO:0017156)2.89619899
78regulation of vesicle fusion (GO:0031338)2.88924067
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.88263100
80retinal cone cell development (GO:0046549)2.87937935
81regulation of synapse maturation (GO:0090128)2.87806264
82sodium ion export (GO:0071436)2.86982450
83synaptic vesicle transport (GO:0048489)2.85678102
84establishment of synaptic vesicle localization (GO:0097480)2.85678102
85neurotransmitter uptake (GO:0001504)2.84632843
86chemosensory behavior (GO:0007635)2.82649055
87neuronal action potential (GO:0019228)2.82308283
88fear response (GO:0042596)2.82187875
89cellular potassium ion transport (GO:0071804)2.81590899
90potassium ion transmembrane transport (GO:0071805)2.81590899
91adult walking behavior (GO:0007628)2.81455717
92mechanosensory behavior (GO:0007638)2.80867535
93long-term memory (GO:0007616)2.78007677
94response to amphetamine (GO:0001975)2.77068705
95cell migration in hindbrain (GO:0021535)2.76440401
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76376670
97C4-dicarboxylate transport (GO:0015740)2.75568697
98glycosphingolipid biosynthetic process (GO:0006688)2.75562385
99nucleobase catabolic process (GO:0046113)2.74172215
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72439645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01735513
2GBX2_23144817_ChIP-Seq_PC3_Human3.55432986
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.37882980
4REST_21632747_ChIP-Seq_MESCs_Mouse3.07070398
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60080811
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44582469
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.39663786
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36949253
9DROSHA_22980978_ChIP-Seq_HELA_Human2.30057566
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.23507535
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21807164
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15203616
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14510554
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11144944
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09839249
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.03627354
17TAF15_26573619_Chip-Seq_HEK293_Human2.01119507
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97645326
19IGF1R_20145208_ChIP-Seq_DFB_Human1.93698232
20ZNF274_21170338_ChIP-Seq_K562_Hela1.93156387
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.92656721
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91088111
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90777083
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90777083
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90660589
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88270676
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.86914954
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85245984
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85205537
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.82682947
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79729302
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74552255
33VDR_22108803_ChIP-Seq_LS180_Human1.73297129
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71128210
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67533929
36P300_19829295_ChIP-Seq_ESCs_Human1.65790096
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64515752
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.60610185
39AR_21572438_ChIP-Seq_LNCaP_Human1.60466219
40RNF2_27304074_Chip-Seq_NSC_Mouse1.59615917
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52588108
42SMAD4_21799915_ChIP-Seq_A2780_Human1.51300747
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49020614
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47849868
45FUS_26573619_Chip-Seq_HEK293_Human1.42759308
46TCF4_23295773_ChIP-Seq_U87_Human1.39423813
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37955546
48STAT3_23295773_ChIP-Seq_U87_Human1.32302116
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.31443240
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28937407
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.28768480
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28470704
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28470704
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27118437
55AR_25329375_ChIP-Seq_VCAP_Human1.25814273
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25746284
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24044091
58BCAT_22108803_ChIP-Seq_LS180_Human1.23264818
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22939854
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22864403
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22747712
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20391707
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19265093
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.18722535
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.17092788
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16930353
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14186765
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12959219
69CBP_20019798_ChIP-Seq_JUKART_Human1.12959219
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12222839
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11471763
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10617655
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.09348955
74RUNX2_22187159_ChIP-Seq_PCA_Human1.08313539
75EWS_26573619_Chip-Seq_HEK293_Human1.07704712
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07000371
77AR_19668381_ChIP-Seq_PC3_Human1.06713004
78TP53_22573176_ChIP-Seq_HFKS_Human1.04871926
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03868372
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03830941
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.03799863
82ER_23166858_ChIP-Seq_MCF-7_Human1.03646981
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02478479
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02133472
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.01490774
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01110551
87TCF4_22108803_ChIP-Seq_LS180_Human1.00606925
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99203550
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99058800
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.98623177
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.97516554
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97278663
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96918586
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96337971
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94837504
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94486021
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.93976093
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93666637
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92594880
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92117324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81049854
2MP0003880_abnormal_central_pattern4.54885379
3MP0003635_abnormal_synaptic_transmissio3.37214487
4MP0009745_abnormal_behavioral_response3.24986606
5MP0002064_seizures3.16754301
6MP0001968_abnormal_touch/_nociception3.16410507
7MP0004270_analgesia3.14247110
8MP0009046_muscle_twitch3.02134234
9MP0005423_abnormal_somatic_nervous2.84541222
10MP0002272_abnormal_nervous_system2.80478957
11MP0001486_abnormal_startle_reflex2.76781539
12MP0002063_abnormal_learning/memory/cond2.74611868
13MP0005646_abnormal_pituitary_gland2.57847667
14MP0002736_abnormal_nociception_after2.53559497
15MP0002572_abnormal_emotion/affect_behav2.53553776
16MP0002734_abnormal_mechanical_nocicepti2.42481169
17MP0002735_abnormal_chemical_nociception2.30740160
18MP0001501_abnormal_sleep_pattern2.25421351
19MP0003787_abnormal_imprinting2.12519492
20MP0000569_abnormal_digit_pigmentation1.98123554
21MP0001970_abnormal_pain_threshold1.90871422
22MP0005551_abnormal_eye_electrophysiolog1.86471994
23MP0001986_abnormal_taste_sensitivity1.83990377
24MP0002822_catalepsy1.83368536
25MP0002557_abnormal_social/conspecific_i1.83352283
26MP0002733_abnormal_thermal_nociception1.82333931
27MP0004885_abnormal_endolymph1.77071240
28MP0002067_abnormal_sensory_capabilities1.76190046
29MP0006276_abnormal_autonomic_nervous1.73499338
30MP0003879_abnormal_hair_cell1.70560603
31MP0008877_abnormal_DNA_methylation1.59414194
32MP0000778_abnormal_nervous_system1.58857182
33MP0001905_abnormal_dopamine_level1.58432524
34MP0004924_abnormal_behavior1.56434002
35MP0005386_behavior/neurological_phenoty1.56434002
36MP0001984_abnormal_olfaction1.55837693
37MP0009780_abnormal_chondrocyte_physiolo1.55105645
38MP0004742_abnormal_vestibular_system1.52990906
39MP0008569_lethality_at_weaning1.47282067
40MP0003122_maternal_imprinting1.42623239
41MP0001440_abnormal_grooming_behavior1.42585836
42MP0004811_abnormal_neuron_physiology1.36401592
43MP0001485_abnormal_pinna_reflex1.34667838
44MP0008872_abnormal_physiological_respon1.34017019
45MP0003633_abnormal_nervous_system1.32956560
46MP0002882_abnormal_neuron_morphology1.30995858
47MP0002066_abnormal_motor_capabilities/c1.27355119
48MP0001502_abnormal_circadian_rhythm1.25958874
49MP0004147_increased_porphyrin_level1.21098759
50MP0002184_abnormal_innervation1.20963723
51MP0000955_abnormal_spinal_cord1.19721420
52MP0002638_abnormal_pupillary_reflex1.18839595
53MP0000631_abnormal_neuroendocrine_gland1.17577479
54MP0001529_abnormal_vocalization1.17348101
55MP0003195_calcinosis1.15686920
56MP0002876_abnormal_thyroid_physiology1.14725967
57MP0003631_nervous_system_phenotype1.11749212
58MP0004142_abnormal_muscle_tone1.11569596
59MP0002229_neurodegeneration1.10670876
60MP0002653_abnormal_ependyma_morphology1.10532037
61MP0003329_amyloid_beta_deposits1.09458512
62MP0008875_abnormal_xenobiotic_pharmacok1.08569211
63MP0001963_abnormal_hearing_physiology1.08222000
64MP0003123_paternal_imprinting1.07548854
65MP0005645_abnormal_hypothalamus_physiol1.07519292
66MP0002909_abnormal_adrenal_gland1.01968241
67MP0001188_hyperpigmentation0.99114070
68MP0003136_yellow_coat_color0.97478173
69MP0002837_dystrophic_cardiac_calcinosis0.94850435
70MP0005253_abnormal_eye_physiology0.94648842
71MP0002102_abnormal_ear_morphology0.93828415
72MP0005174_abnormal_tail_pigmentation0.92495976
73MP0002152_abnormal_brain_morphology0.91679044
74MP0006072_abnormal_retinal_apoptosis0.89983091
75MP0002752_abnormal_somatic_nervous0.88125603
76MP0004043_abnormal_pH_regulation0.85197080
77MP0003283_abnormal_digestive_organ0.85091812
78MP0010386_abnormal_urinary_bladder0.83765614
79MP0005187_abnormal_penis_morphology0.83310514
80MP0001177_atelectasis0.82932002
81MP0003121_genomic_imprinting0.81922904
82MP0003137_abnormal_impulse_conducting0.80424966
83MP0006292_abnormal_olfactory_placode0.80175661
84MP0003632_abnormal_nervous_system0.79117847
85MP0004133_heterotaxia0.78681170
86MP0000026_abnormal_inner_ear0.76106206
87MP0002069_abnormal_eating/drinking_beha0.75194636
88MP0000920_abnormal_myelination0.74827421
89MP0000427_abnormal_hair_cycle0.71696984
90MP0002090_abnormal_vision0.70022561
91MP0000372_irregular_coat_pigmentation0.68386210
92MP0000639_abnormal_adrenal_gland0.65521667
93MP0002234_abnormal_pharynx_morphology0.62649469
94MP0002160_abnormal_reproductive_system0.62403107
95MP0003690_abnormal_glial_cell0.62136237
96MP0005167_abnormal_blood-brain_barrier0.61485590
97MP0005499_abnormal_olfactory_system0.58911372
98MP0005394_taste/olfaction_phenotype0.58911372
99MP0002938_white_spotting0.57748457
100MP0004215_abnormal_myocardial_fiber0.57746978

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.95439085
2Myokymia (HP:0002411)5.94562437
3Focal seizures (HP:0007359)5.29077245
4Febrile seizures (HP:0002373)4.98327178
5Epileptic encephalopathy (HP:0200134)4.45280844
6Atonic seizures (HP:0010819)4.09539885
7Progressive cerebellar ataxia (HP:0002073)4.09347795
8Hyperventilation (HP:0002883)3.64262178
9Limb dystonia (HP:0002451)3.57707578
10Dialeptic seizures (HP:0011146)3.55138133
11Generalized tonic-clonic seizures (HP:0002069)3.49164748
12Action tremor (HP:0002345)3.35990905
13Gaze-evoked nystagmus (HP:0000640)3.22431809
14Broad-based gait (HP:0002136)3.22311011
15Absence seizures (HP:0002121)3.14265900
16Visual hallucinations (HP:0002367)3.13711199
17Abnormality of binocular vision (HP:0011514)2.96244310
18Diplopia (HP:0000651)2.96244310
19Epileptiform EEG discharges (HP:0011182)2.95197993
20Cerebral hypomyelination (HP:0006808)2.82832788
21Hemiparesis (HP:0001269)2.81922749
22Status epilepticus (HP:0002133)2.81588370
23Absent speech (HP:0001344)2.77281388
24Abnormal eating behavior (HP:0100738)2.74777477
25EEG with generalized epileptiform discharges (HP:0011198)2.70313709
26Ankle clonus (HP:0011448)2.65427344
27Hypsarrhythmia (HP:0002521)2.63456510
28Congenital stationary night blindness (HP:0007642)2.63180956
29Poor eye contact (HP:0000817)2.55313013
30Type II lissencephaly (HP:0007260)2.49820238
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47637570
32Abnormality of alanine metabolism (HP:0010916)2.47637570
33Hyperalaninemia (HP:0003348)2.47637570
34Postural instability (HP:0002172)2.40717931
35Anxiety (HP:0000739)2.40140001
36Amblyopia (HP:0000646)2.38232709
37Urinary bladder sphincter dysfunction (HP:0002839)2.35777321
38Pancreatic cysts (HP:0001737)2.35356518
39Decreased central vision (HP:0007663)2.33794127
40Hemiplegia (HP:0002301)2.33492088
41Polyphagia (HP:0002591)2.31459987
42Pancreatic fibrosis (HP:0100732)2.30418446
43Inability to walk (HP:0002540)2.28622367
44Abnormality of midbrain morphology (HP:0002418)2.27500229
45Molar tooth sign on MRI (HP:0002419)2.27500229
46Nephronophthisis (HP:0000090)2.27471549
47Gait imbalance (HP:0002141)2.26865059
48Genetic anticipation (HP:0003743)2.25358017
49Drooling (HP:0002307)2.22977348
50Delusions (HP:0000746)2.22955165
51Impaired vibration sensation in the lower limbs (HP:0002166)2.22621524
52Medial flaring of the eyebrow (HP:0010747)2.21388969
53Spastic gait (HP:0002064)2.20480480
54Polydipsia (HP:0001959)2.19460069
55Abnormal drinking behavior (HP:0030082)2.19460069
56Torticollis (HP:0000473)2.17969860
57True hermaphroditism (HP:0010459)2.13473157
58Abnormality of the corticospinal tract (HP:0002492)2.13299849
59CNS hypomyelination (HP:0003429)2.04336239
60Dysdiadochokinesis (HP:0002075)2.02546585
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01033729
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.01033729
63Supranuclear gaze palsy (HP:0000605)2.00700276
64Truncal ataxia (HP:0002078)1.99587425
65Agitation (HP:0000713)1.98439878
66Impaired social interactions (HP:0000735)1.98388668
67Abnormal social behavior (HP:0012433)1.98388668
68Excessive salivation (HP:0003781)1.96010774
69Akinesia (HP:0002304)1.94724784
70Mutism (HP:0002300)1.92839801
71Morphological abnormality of the pyramidal tract (HP:0002062)1.92642882
72Chronic hepatic failure (HP:0100626)1.92483986
73Protruding tongue (HP:0010808)1.91578271
74Dyskinesia (HP:0100660)1.90468659
75Impaired smooth pursuit (HP:0007772)1.90099868
76Optic nerve hypoplasia (HP:0000609)1.89975920
77Abnormality of the renal medulla (HP:0100957)1.89786088
78Urinary urgency (HP:0000012)1.86885442
79Focal dystonia (HP:0004373)1.86323404
80Sleep apnea (HP:0010535)1.81924995
81Abnormality of the renal cortex (HP:0011035)1.81143724
82Attenuation of retinal blood vessels (HP:0007843)1.78413348
83Dysmetria (HP:0001310)1.77245276
84Abnormality of the labia minora (HP:0012880)1.75783137
85Specific learning disability (HP:0001328)1.75215172
86Congenital primary aphakia (HP:0007707)1.74991076
87Progressive macrocephaly (HP:0004481)1.74341328
88Clonus (HP:0002169)1.74318213
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74143845
90Intention tremor (HP:0002080)1.72770959
91Retinal dysplasia (HP:0007973)1.72392012
92Progressive inability to walk (HP:0002505)1.71980172
93Prolonged QT interval (HP:0001657)1.71905720
94Polyuria (HP:0000103)1.71799514
95Muscular hypotonia of the trunk (HP:0008936)1.70394762
96Spastic tetraplegia (HP:0002510)1.70183824
97Abnormal EKG (HP:0003115)1.69426653
98Papilledema (HP:0001085)1.68288416
99Progressive microcephaly (HP:0000253)1.67403421
100Acute necrotizing encephalopathy (HP:0006965)1.66728921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.81158813
2DAPK23.50714220
3NTRK33.45914548
4MARK13.42102307
5FRK3.37327054
6CASK3.26799141
7PAK62.82174566
8PINK12.80754436
9MAPK132.31428578
10NTRK22.12713894
11SIK21.93624847
12MINK11.91545861
13PRKD31.83385036
14MAP3K91.82086241
15UHMK11.76478864
16MAP3K41.69584858
17PLK21.67842963
18PRKCG1.61194699
19INSRR1.59129579
20ADRBK21.53593869
21PAK31.53126135
22CAMKK11.43560511
23WNK31.43266723
24OXSR11.36310063
25CAMK11.35706838
26MAP4K21.33202316
27PHKG21.32849034
28PHKG11.32849034
29MAP2K71.28978097
30CDK51.26923390
31PNCK1.22530137
32GRK51.21292667
33DAPK11.20453541
34CSNK1G21.19526801
35WNK41.18749506
36CAMKK21.11230414
37TLK11.07110942
38CAMK2A1.06947780
39CDK191.06528180
40SGK2231.02473636
41SGK4941.02473636
42FGFR21.01676789
43ZAK0.98728334
44CAMK2B0.96200771
45TAOK30.96193509
46TRIM280.93921084
47GRK10.93541336
48PRKCH0.93343058
49STK110.91737147
50NTRK10.88369459
51PKN10.87631089
52DYRK1A0.87252697
53DYRK20.85143345
54CSNK1G30.80823900
55BMPR1B0.78500330
56SGK20.77019893
57PRKCE0.74365443
58CSNK1G10.73145307
59MAP3K120.71270591
60STK380.70423233
61ACVR1B0.70157563
62STK390.68457232
63MAP2K40.67966665
64CCNB10.64577047
65CSNK1A1L0.63540626
66CDK180.61627041
67CDK150.60072604
68PRKCZ0.59933867
69CAMK2G0.56939752
70ADRBK10.56874308
71CAMK40.56689504
72TNIK0.56139386
73TNK20.55235631
74CDK140.52709653
75SGK10.51336943
76CAMK1G0.50772565
77CAMK2D0.50736083
78MAPKAPK50.49931255
79CDK11A0.48909588
80PRKACA0.48528124
81PRKCA0.48037979
82MAP2K60.47358468
83BCR0.46945308
84TYRO30.45472598
85RPS6KA30.43518748
86PDK10.42865280
87MUSK0.41202559
88CSNK1D0.40217051
89TXK0.38739348
90CSNK1A10.38296858
91PTK2B0.37961868
92NUAK10.36730538
93NEK60.35429892
94BRSK10.34337613
95CSNK1E0.32628021
96ERBB20.32626733
97SGK30.32105302
98PRKG20.31060304
99PLK30.29276646
100PRKG10.29156772

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.54018206
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31250781
3GABAergic synapse_Homo sapiens_hsa047272.68263873
4Morphine addiction_Homo sapiens_hsa050322.67797375
5Circadian entrainment_Homo sapiens_hsa047132.67336889
6Glutamatergic synapse_Homo sapiens_hsa047242.60787915
7Insulin secretion_Homo sapiens_hsa049112.57758968
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47155870
9Amphetamine addiction_Homo sapiens_hsa050312.40602483
10Phototransduction_Homo sapiens_hsa047442.26760546
11Dopaminergic synapse_Homo sapiens_hsa047282.01401926
12Taste transduction_Homo sapiens_hsa047421.89002701
13Cocaine addiction_Homo sapiens_hsa050301.85454101
14Vitamin B6 metabolism_Homo sapiens_hsa007501.79274239
15Long-term potentiation_Homo sapiens_hsa047201.76716622
16Salivary secretion_Homo sapiens_hsa049701.70830684
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70591789
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70117169
19Oxidative phosphorylation_Homo sapiens_hsa001901.58464109
20Gastric acid secretion_Homo sapiens_hsa049711.57236618
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53950265
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46224351
23Olfactory transduction_Homo sapiens_hsa047401.44902714
24Calcium signaling pathway_Homo sapiens_hsa040201.40088322
25Butanoate metabolism_Homo sapiens_hsa006501.39189699
26Collecting duct acid secretion_Homo sapiens_hsa049661.38942889
27Cardiac muscle contraction_Homo sapiens_hsa042601.38073250
28Cholinergic synapse_Homo sapiens_hsa047251.32520921
29Serotonergic synapse_Homo sapiens_hsa047261.31987135
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26414636
31Nitrogen metabolism_Homo sapiens_hsa009101.26230621
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24825336
33Oxytocin signaling pathway_Homo sapiens_hsa049211.22811033
34Parkinsons disease_Homo sapiens_hsa050121.20771671
35Long-term depression_Homo sapiens_hsa047301.16545573
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16341995
37Alzheimers disease_Homo sapiens_hsa050101.15802532
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.14050932
39cAMP signaling pathway_Homo sapiens_hsa040241.13217063
40Renin secretion_Homo sapiens_hsa049241.11798203
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10869839
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09576620
43Linoleic acid metabolism_Homo sapiens_hsa005911.06924502
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04040861
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97466974
46Caffeine metabolism_Homo sapiens_hsa002320.90819723
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.87556340
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86179463
49Ether lipid metabolism_Homo sapiens_hsa005650.83394008
50Bile secretion_Homo sapiens_hsa049760.81080444
51Tryptophan metabolism_Homo sapiens_hsa003800.79653582
52Regulation of autophagy_Homo sapiens_hsa041400.78553227
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78485337
54Pancreatic secretion_Homo sapiens_hsa049720.78387606
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76534494
56Ovarian steroidogenesis_Homo sapiens_hsa049130.76378516
57Circadian rhythm_Homo sapiens_hsa047100.75118115
58beta-Alanine metabolism_Homo sapiens_hsa004100.74034106
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72588224
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71019955
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70811372
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70138737
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.70073988
64Huntingtons disease_Homo sapiens_hsa050160.68178066
65Oocyte meiosis_Homo sapiens_hsa041140.68154652
66Histidine metabolism_Homo sapiens_hsa003400.67869716
67Arginine biosynthesis_Homo sapiens_hsa002200.65900287
68Axon guidance_Homo sapiens_hsa043600.65129188
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64657838
70Arginine and proline metabolism_Homo sapiens_hsa003300.60841781
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60306995
72Melanogenesis_Homo sapiens_hsa049160.58510823
73ABC transporters_Homo sapiens_hsa020100.58102235
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57885321
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.57623303
76Gap junction_Homo sapiens_hsa045400.55454364
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54211322
78Type II diabetes mellitus_Homo sapiens_hsa049300.54010121
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52728287
80Thyroid hormone synthesis_Homo sapiens_hsa049180.51502243
81Propanoate metabolism_Homo sapiens_hsa006400.51336005
82Chemical carcinogenesis_Homo sapiens_hsa052040.50538756
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49697595
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48876590
85Peroxisome_Homo sapiens_hsa041460.47408471
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44136245
87Glucagon signaling pathway_Homo sapiens_hsa049220.43122196
88Sulfur relay system_Homo sapiens_hsa041220.42225239
89GnRH signaling pathway_Homo sapiens_hsa049120.41771978
90Mineral absorption_Homo sapiens_hsa049780.39087348
91Retinol metabolism_Homo sapiens_hsa008300.37797312
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37263019
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37194807
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36265163
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36219609
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35830858
97Dorso-ventral axis formation_Homo sapiens_hsa043200.35784881
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35131296
99Estrogen signaling pathway_Homo sapiens_hsa049150.33928476
100Ras signaling pathway_Homo sapiens_hsa040140.33320688

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