DGCR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.71880365
2nuclear pore complex assembly (GO:0051292)5.53898421
3nuclear pore organization (GO:0006999)5.24153783
4protein localization to kinetochore (GO:0034501)4.97357994
5mitotic sister chromatid cohesion (GO:0007064)4.77240787
6regulation of translational fidelity (GO:0006450)4.67758230
7DNA replication initiation (GO:0006270)4.63822033
8mitotic chromosome condensation (GO:0007076)4.45461398
9sister chromatid segregation (GO:0000819)4.43868747
10mitotic sister chromatid segregation (GO:0000070)4.32917006
11DNA strand elongation involved in DNA replication (GO:0006271)4.31992756
12mitotic nuclear envelope disassembly (GO:0007077)4.30832714
13regulation of histone H3-K27 methylation (GO:0061085)4.28508829
14DNA damage induced protein phosphorylation (GO:0006975)4.27769041
15dosage compensation (GO:0007549)4.27163697
16protein localization to chromosome, centromeric region (GO:0071459)4.23512197
17DNA strand elongation (GO:0022616)4.22427422
18protein-DNA complex disassembly (GO:0032986)4.15354299
19nucleosome disassembly (GO:0006337)4.15354299
20pore complex assembly (GO:0046931)4.13592712
21kinetochore organization (GO:0051383)4.05016448
22DNA replication-dependent nucleosome assembly (GO:0006335)4.04314448
23DNA replication-dependent nucleosome organization (GO:0034723)4.04314448
24regulation of histone H3-K9 methylation (GO:0051570)4.03396656
25membrane disassembly (GO:0030397)4.02457448
26nuclear envelope disassembly (GO:0051081)4.02457448
27DNA duplex unwinding (GO:0032508)4.00377699
28DNA geometric change (GO:0032392)4.00300342
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99429443
30pre-miRNA processing (GO:0031054)3.96590497
31DNA packaging (GO:0006323)3.91562326
32regulation of nucleobase-containing compound transport (GO:0032239)3.85618771
33regulation of histone H3-K4 methylation (GO:0051569)3.85062790
34DNA synthesis involved in DNA repair (GO:0000731)3.79824462
35IMP biosynthetic process (GO:0006188)3.77804571
36regulation of DNA endoreduplication (GO:0032875)3.77480461
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76905786
38attachment of spindle microtubules to kinetochore (GO:0008608)3.73935122
39proline biosynthetic process (GO:0006561)3.72810996
40telomere maintenance via semi-conservative replication (GO:0032201)3.71303798
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70404941
42DNA replication checkpoint (GO:0000076)3.63256162
43mitotic recombination (GO:0006312)3.63120712
44chromatin remodeling at centromere (GO:0031055)3.57582615
45DNA replication-independent nucleosome assembly (GO:0006336)3.57488728
46DNA replication-independent nucleosome organization (GO:0034724)3.57488728
47negative regulation of histone methylation (GO:0031061)3.54676039
48CENP-A containing nucleosome assembly (GO:0034080)3.54039005
49chromatin assembly or disassembly (GO:0006333)3.53862962
50telomere maintenance via recombination (GO:0000722)3.49533442
51heterochromatin organization (GO:0070828)3.47515718
52kinetochore assembly (GO:0051382)3.46037729
53mitotic metaphase plate congression (GO:0007080)3.45215427
54translesion synthesis (GO:0019985)3.42417749
55regulation of spindle organization (GO:0090224)3.41116453
56protein localization to chromosome (GO:0034502)3.40925463
57regulation of centriole replication (GO:0046599)3.40498929
58histone H2A acetylation (GO:0043968)3.40289014
59regulation of histone methylation (GO:0031060)3.40141604
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.39246368
61chromatin assembly (GO:0031497)3.38410456
62negative regulation of RNA splicing (GO:0033119)3.38384132
63regulation of RNA export from nucleus (GO:0046831)3.34751062
64regulation of helicase activity (GO:0051095)3.34074302
65DNA conformation change (GO:0071103)3.32952981
66IMP metabolic process (GO:0046040)3.30207757
67DNA strand renaturation (GO:0000733)3.29283078
68negative regulation of erythrocyte differentiation (GO:0045647)3.28963065
69regulation of sister chromatid cohesion (GO:0007063)3.27289376
70metaphase plate congression (GO:0051310)3.25626289
71regulation of centrosome cycle (GO:0046605)3.24469223
72positive regulation of chromosome segregation (GO:0051984)3.22164554
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21099101
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18240882
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.18240882
76histone exchange (GO:0043486)3.17623452
77regulation of chromosome segregation (GO:0051983)3.16501224
78negative regulation of mRNA processing (GO:0050686)3.16381649
79meiotic chromosome segregation (GO:0045132)3.14837389
80mRNA cleavage (GO:0006379)3.13724709
81chromosome segregation (GO:0007059)3.12636405
82mannose metabolic process (GO:0006013)3.12492185
83nucleobase biosynthetic process (GO:0046112)3.12328448
84ATP-dependent chromatin remodeling (GO:0043044)3.10005111
85nuclear envelope organization (GO:0006998)3.09144178
86chromatin silencing (GO:0006342)3.08596966
87protein export from nucleus (GO:0006611)3.08505533
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.06012794
89telomere maintenance via telomere lengthening (GO:0010833)3.05942218
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.05249683
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05249683
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05249683
93postreplication repair (GO:0006301)3.04066937
94mismatch repair (GO:0006298)3.03968010
95chromosome condensation (GO:0030261)3.02649847
96regulation of mitotic spindle organization (GO:0060236)3.02451636
97negative regulation of gene expression, epigenetic (GO:0045814)3.02108213
98folic acid metabolic process (GO:0046655)3.02006177
99spindle assembly checkpoint (GO:0071173)3.00858497
100negative regulation of chromosome segregation (GO:0051985)3.00575697
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00003933
102hematopoietic stem cell differentiation (GO:0060218)2.99855351
103positive regulation of gene expression, epigenetic (GO:0045815)2.99563557
104mRNA transport (GO:0051028)2.99467330
105spindle checkpoint (GO:0031577)2.99223785
106regulation of NFAT protein import into nucleus (GO:0051532)2.99062861
107establishment of chromosome localization (GO:0051303)2.98689461
108formation of translation preinitiation complex (GO:0001731)2.98205173
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98090988
110snRNA processing (GO:0016180)2.98012007
111regulation of chromatin binding (GO:0035561)2.97790319
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.97618748
113regulation of DNA damage checkpoint (GO:2000001)2.97560778
114folic acid-containing compound biosynthetic process (GO:0009396)2.97547311
115spliceosomal tri-snRNP complex assembly (GO:0000244)2.95605980
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94927860
117negative regulation of sister chromatid segregation (GO:0033046)2.94927860
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.94927860
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94927860
120DNA topological change (GO:0006265)2.93608774
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92090457
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91991428
123regulation of centrosome duplication (GO:0010824)2.91924722
124negative regulation of mRNA metabolic process (GO:1903312)2.91090423
125mRNA stabilization (GO:0048255)2.89226229
126RNA stabilization (GO:0043489)2.89226229
127intracellular estrogen receptor signaling pathway (GO:0030520)2.86631663
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75942768
129negative regulation of telomerase activity (GO:0051974)2.75484436
130snRNA metabolic process (GO:0016073)2.75348458
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.72013689
132histone H4 deacetylation (GO:0070933)2.71675662
133rRNA methylation (GO:0031167)2.71389530
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71067480
135histone phosphorylation (GO:0016572)2.68298920
136neural tube development (GO:0021915)2.64196166
137peptidyl-lysine dimethylation (GO:0018027)2.63759309
138response to epidermal growth factor (GO:0070849)2.62928380
139positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62879962
140mitotic G1 DNA damage checkpoint (GO:0031571)2.62286463
141histone H3-K4 methylation (GO:0051568)2.60802695
142glucocorticoid receptor signaling pathway (GO:0042921)2.59040011
143cellular response to epidermal growth factor stimulus (GO:0071364)2.57953208
144histone lysine demethylation (GO:0070076)2.53216320
145RNA transport (GO:0050658)2.50877975
146establishment of RNA localization (GO:0051236)2.50877975
147nucleic acid transport (GO:0050657)2.50877975
148convergent extension (GO:0060026)2.49933885
149stress granule assembly (GO:0034063)2.49662715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.09259360
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.85383759
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45537623
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.44055223
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98891529
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.87476119
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.69998966
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64186268
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56862310
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43524911
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.32970666
12AR_21909140_ChIP-Seq_LNCAP_Human2.30923131
13MYC_22102868_ChIP-Seq_BL_Human2.30109271
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15935840
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15118584
16LXR_22292898_ChIP-Seq_THP-1_Human2.11556840
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.11071772
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10965858
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04785914
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02080864
21CIITA_25753668_ChIP-Seq_RAJI_Human2.01220419
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00960334
23E2F7_22180533_ChIP-Seq_HELA_Human12.1528564
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96503569
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95819423
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93216055
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88816858
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88577998
29* NCOR1_26117541_ChIP-Seq_K562_Human1.86457337
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86127133
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.84082843
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82412064
33* XRN2_22483619_ChIP-Seq_HELA_Human1.80948770
34KDM2B_26808549_Chip-Seq_DND41_Human1.69890964
35P68_20966046_ChIP-Seq_HELA_Human1.66093837
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.65802041
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65362993
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62043184
39RACK7_27058665_Chip-Seq_MCF-7_Human1.59818161
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59328815
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57997105
42VDR_23849224_ChIP-Seq_CD4+_Human1.56149024
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55671668
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54839101
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53625996
46FOXP3_21729870_ChIP-Seq_TREG_Human1.51482688
47* MAF_26560356_Chip-Seq_TH2_Human1.51227098
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.48468329
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47121445
50KDM2B_26808549_Chip-Seq_K562_Human1.46377654
51TTF2_22483619_ChIP-Seq_HELA_Human1.45555680
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43488861
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42773864
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42037719
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.41614746
56KDM5A_27292631_Chip-Seq_BREAST_Human1.41600221
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39755603
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38645950
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36138564
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34901867
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34255449
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34145060
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34009742
64CREB1_26743006_Chip-Seq_LNCaP_Human1.33992428
65SMC4_20622854_ChIP-Seq_HELA_Human1.33667513
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32303704
67MAF_26560356_Chip-Seq_TH1_Human1.30521135
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.29225346
69ELK1_19687146_ChIP-ChIP_HELA_Human1.28912398
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27719642
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27065580
72ZNF263_19887448_ChIP-Seq_K562_Human1.25573983
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25554455
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25200930
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.24770751
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24653012
77GABP_19822575_ChIP-Seq_HepG2_Human1.23393414
78* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22729978
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21708954
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.21582356
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21499619
82* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21463584
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.21221723
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20454013
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19525346
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19348849
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18805599
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17987032
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17648070
90* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17446430
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16577719
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14974420
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12938676
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.11757119
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11599758
96* DCP1A_22483619_ChIP-Seq_HELA_Human1.11557612
97VDR_21846776_ChIP-Seq_THP-1_Human1.10693441
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10603492
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09069704
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.08941250
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07701545
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07568488
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07268864
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07161894
105PHF8_20622854_ChIP-Seq_HELA_Human1.07044626
106* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06049458
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04877135
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04618961
109GATA1_19941826_ChIP-Seq_K562_Human1.04126667
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04047193
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03554459
112BCOR_27268052_Chip-Seq_Bcells_Human1.03399763
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03058854
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02957570
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.02608867
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02397483
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01959019
118CTCF_21964334_Chip-Seq_Bcells_Human1.01757167
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01357698
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01175164
121TP53_22127205_ChIP-Seq_IMR90_Human1.00519695
122ATF3_27146783_Chip-Seq_COLON_Human0.99845239
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99727947
124PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98810344
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98639598
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97672421
127CTCF_27219007_Chip-Seq_Bcells_Human0.97169309
128VDR_24763502_ChIP-Seq_THP-1_Human0.96499331
129GABP_17652178_ChIP-ChIP_JURKAT_Human0.96303897
130TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89937001
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.89383694
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89025078
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88997162
134TFEB_21752829_ChIP-Seq_HELA_Human0.88391881
135TCF7_22412390_ChIP-Seq_EML_Mouse0.86653766
136* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85793741
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82782174
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82288676
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81257672
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79411319
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.79396376
142UTX_26944678_Chip-Seq_JUKART_Human0.77094226
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76417209
144CHD1_26751641_Chip-Seq_LNCaP_Human0.76138432
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.76103145
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76040394
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75451247
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75320428
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.72683494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.53274972
2MP0010094_abnormal_chromosome_stability4.32556398
3MP0003111_abnormal_nucleus_morphology4.23974581
4MP0003693_abnormal_embryo_hatching3.57163154
5MP0003077_abnormal_cell_cycle3.53281534
6MP0003123_paternal_imprinting3.28970514
7MP0003121_genomic_imprinting3.03533430
8MP0004957_abnormal_blastocyst_morpholog3.03024966
9MP0008877_abnormal_DNA_methylation2.89574931
10MP0008058_abnormal_DNA_repair2.80610902
11MP0003787_abnormal_imprinting2.52553059
12MP0008007_abnormal_cellular_replicative2.52470008
13MP0005171_absent_coat_pigmentation2.39780989
14MP0010352_gastrointestinal_tract_polyps2.32499658
15MP0000678_abnormal_parathyroid_gland2.32479290
16MP0000569_abnormal_digit_pigmentation2.29829175
17MP0002249_abnormal_larynx_morphology2.21436773
18MP0002396_abnormal_hematopoietic_system2.21036886
19MP0000350_abnormal_cell_proliferation2.20119823
20MP0010307_abnormal_tumor_latency2.15752814
21MP0001730_embryonic_growth_arrest2.14798951
22MP0005451_abnormal_body_composition2.14000726
23MP0008932_abnormal_embryonic_tissue2.10653324
24MP0005083_abnormal_biliary_tract1.95156096
25MP0001672_abnormal_embryogenesis/_devel1.91608949
26MP0005380_embryogenesis_phenotype1.91608949
27MP0004197_abnormal_fetal_growth/weight/1.91404428
28MP0003890_abnormal_embryonic-extraembry1.91239026
29MP0001697_abnormal_embryo_size1.80856009
30MP0004808_abnormal_hematopoietic_stem1.79976419
31MP0003984_embryonic_growth_retardation1.79397190
32MP0002084_abnormal_developmental_patter1.78729101
33MP0002088_abnormal_embryonic_growth/wei1.76040009
34MP0002085_abnormal_embryonic_tissue1.74784968
35MP0005076_abnormal_cell_differentiation1.74234308
36MP0010030_abnormal_orbit_morphology1.71902665
37MP0005409_darkened_coat_color1.66986522
38MP0002086_abnormal_extraembryonic_tissu1.66018898
39MP0003122_maternal_imprinting1.60665839
40* MP0002080_prenatal_lethality1.53715992
41MP0008995_early_reproductive_senescence1.53540261
42MP0004185_abnormal_adipocyte_glucose1.45742229
43MP0001293_anophthalmia1.41605682
44MP0009053_abnormal_anal_canal1.41536815
45MP0003567_abnormal_fetal_cardiomyocyte1.37749389
46MP0001661_extended_life_span1.35744105
47MP0000313_abnormal_cell_death1.29090353
48MP0000003_abnormal_adipose_tissue1.28632144
49MP0000490_abnormal_crypts_of1.26385426
50MP0000537_abnormal_urethra_morphology1.25613955
51MP0000428_abnormal_craniofacial_morphol1.23768173
52MP0003786_premature_aging1.23414539
53MP0003119_abnormal_digestive_system1.22890346
54MP0009703_decreased_birth_body1.22580073
55MP0000733_abnormal_muscle_development1.20133306
56MP0003705_abnormal_hypodermis_morpholog1.16588092
57MP0000747_muscle_weakness1.16072462
58MP0004147_increased_porphyrin_level1.14675271
59MP0004858_abnormal_nervous_system1.13766093
60MP0000703_abnormal_thymus_morphology1.12514636
61MP0009672_abnormal_birth_weight1.11999046
62MP0002877_abnormal_melanocyte_morpholog1.10678091
63MP0003453_abnormal_keratinocyte_physiol1.09676370
64MP0003937_abnormal_limbs/digits/tail_de1.09635378
65MP0003942_abnormal_urinary_system1.07844589
66MP0010630_abnormal_cardiac_muscle1.05575846
67MP0002019_abnormal_tumor_incidence1.03753251
68MP0001348_abnormal_lacrimal_gland1.03387204
69MP0000566_synostosis1.02808174
70MP0002210_abnormal_sex_determination1.02747577
71MP0002089_abnormal_postnatal_growth/wei1.01317577
72MP0003935_abnormal_craniofacial_develop1.00561978
73MP0003941_abnormal_skin_development1.00337152
74MP0003861_abnormal_nervous_system0.99498445
75MP0003136_yellow_coat_color0.96995026
76MP0005397_hematopoietic_system_phenotyp0.96348761
77MP0001545_abnormal_hematopoietic_system0.96348761
78MP0002925_abnormal_cardiovascular_devel0.96314258
79MP0009278_abnormal_bone_marrow0.96202918
80MP0003385_abnormal_body_wall0.95727654
81MP0009697_abnormal_copulation0.95272807
82MP0003115_abnormal_respiratory_system0.94518528
83MP0002111_abnormal_tail_morphology0.93028470
84MP0000759_abnormal_skeletal_muscle0.92732956
85MP0000751_myopathy0.91854851
86MP0004087_abnormal_muscle_fiber0.90762777
87MP0001849_ear_inflammation0.89377547
88MP0006292_abnormal_olfactory_placode0.88297837
89MP0002075_abnormal_coat/hair_pigmentati0.88080052
90MP0001145_abnormal_male_reproductive0.87557918
91MP0005501_abnormal_skin_physiology0.85933779
92MP0002938_white_spotting0.85643110
93MP0008770_decreased_survivor_rate0.85429075
94MP0000432_abnormal_head_morphology0.84819576
95MP0002092_abnormal_eye_morphology0.84815833
96MP0002398_abnormal_bone_marrow0.83332815
97MP0001929_abnormal_gametogenesis0.82496823
98MP0005384_cellular_phenotype0.81952436
99MP0010234_abnormal_vibrissa_follicle0.81525135
100MP0004272_abnormal_basement_membrane0.81446159
101MP0003763_abnormal_thymus_physiology0.81404959
102MP0001346_abnormal_lacrimal_gland0.80530793
103MP0009931_abnormal_skin_appearance0.80081143
104MP0004145_abnormal_muscle_electrophysio0.79948655
105MP0001286_abnormal_eye_development0.78241429
106MP0001915_intracranial_hemorrhage0.77733227
107MP0005621_abnormal_cell_physiology0.77368122
108MP0002269_muscular_atrophy0.77262268
109MP0003566_abnormal_cell_adhesion0.77233917
110MP0002114_abnormal_axial_skeleton0.77036975
111MP0003755_abnormal_palate_morphology0.76110629
112MP0002160_abnormal_reproductive_system0.74751051
113MP0002970_abnormal_white_adipose0.74491231
114MP0004264_abnormal_extraembryonic_tissu0.74405303
115MP0003091_abnormal_cell_migration0.72464996
116MP0002932_abnormal_joint_morphology0.72318455
117MP0002697_abnormal_eye_size0.72296664
118MP0005375_adipose_tissue_phenotype0.72151450
119MP0008438_abnormal_cutaneous_collagen0.71736150
120MP0002060_abnormal_skin_morphology0.71531051
121* MP0000266_abnormal_heart_morphology0.70682603
122MP0002081_perinatal_lethality0.69457060
123MP0000653_abnormal_sex_gland0.69372700
124MP0003698_abnormal_male_reproductive0.69114379
125MP0002116_abnormal_craniofacial_bone0.67918984
126MP0006054_spinal_hemorrhage0.67155317
127MP0002722_abnormal_immune_system0.66740554
128MP0002234_abnormal_pharynx_morphology0.66198252
129MP0008789_abnormal_olfactory_epithelium0.66112157
130MP0003315_abnormal_perineum_morphology0.66066646
131MP0001186_pigmentation_phenotype0.65825178
132MP0003943_abnormal_hepatobiliary_system0.65227815
133MP0000371_diluted_coat_color0.64652129
134MP0005499_abnormal_olfactory_system0.64598375
135MP0005394_taste/olfaction_phenotype0.64598375
136MP0005174_abnormal_tail_pigmentation0.64466037
137MP0004133_heterotaxia0.64245145
138MP0004233_abnormal_muscle_weight0.63398640

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.58064108
2Medulloblastoma (HP:0002885)3.53059238
3Birth length less than 3rd percentile (HP:0003561)3.49182746
4Abnormality of the labia minora (HP:0012880)3.44969790
5Chromsome breakage (HP:0040012)3.41181885
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41013916
7Truncus arteriosus (HP:0001660)3.37729035
8Ependymoma (HP:0002888)3.35099905
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.30003141
10Short 4th metacarpal (HP:0010044)3.30003141
11Ulnar bowing (HP:0003031)3.28039691
12Hyperthyroidism (HP:0000836)3.12841358
13Increased nuchal translucency (HP:0010880)3.09426069
14Bowel incontinence (HP:0002607)3.03901678
15Abnormality of the fingertips (HP:0001211)2.89973815
16Colon cancer (HP:0003003)2.83965085
17Abnormal large intestine physiology (HP:0012700)2.83742793
18Astrocytoma (HP:0009592)2.81696523
19Abnormality of the astrocytes (HP:0100707)2.81696523
20Agnosia (HP:0010524)2.80878332
21Squamous cell carcinoma (HP:0002860)2.79502109
22Renal duplication (HP:0000075)2.79110407
23Abnormality of cochlea (HP:0000375)2.76909202
24Hyperacusis (HP:0010780)2.75693991
25Selective tooth agenesis (HP:0001592)2.74229405
26Ectopic kidney (HP:0000086)2.73467632
27Turricephaly (HP:0000262)2.72483534
28Thin ribs (HP:0000883)2.67952510
29Abnormality of the aortic arch (HP:0012303)2.65359466
30Reticulocytosis (HP:0001923)2.62584490
31Glioma (HP:0009733)2.58707234
32Patellar aplasia (HP:0006443)2.57527400
33Poikiloderma (HP:0001029)2.57496730
34Neoplasm of the oral cavity (HP:0100649)2.56801340
35Pelvic girdle muscle weakness (HP:0003749)2.55904137
36Insomnia (HP:0100785)2.54837711
37Abnormality of chromosome stability (HP:0003220)2.51316239
38Rhabdomyosarcoma (HP:0002859)2.47168308
39Meckel diverticulum (HP:0002245)2.46148600
40Patellar dislocation (HP:0002999)2.43571102
41Progressive muscle weakness (HP:0003323)2.42380933
42Deviation of the thumb (HP:0009603)2.41901383
43Prominent nose (HP:0000448)2.40776032
44Atelectasis (HP:0100750)2.40756267
45Increased connective tissue (HP:0009025)2.40382080
46Long eyelashes (HP:0000527)2.40360770
47Proximal placement of thumb (HP:0009623)2.38841837
48Impulsivity (HP:0100710)2.38021690
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.37244618
50Abnormality of the ileum (HP:0001549)2.37240505
51Aplasia/Hypoplasia of the patella (HP:0006498)2.35923237
52Abnormality of the carotid arteries (HP:0005344)2.34812288
53Renovascular hypertension (HP:0100817)2.33686801
54Ankyloglossia (HP:0010296)2.33301410
55Intestinal fistula (HP:0100819)2.33248174
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.32801434
57Abnormality of reticulocytes (HP:0004312)2.30353759
58Disproportionate tall stature (HP:0001519)2.29500911
59Urethral obstruction (HP:0000796)2.28479354
60Abnormality of DNA repair (HP:0003254)2.27899806
61Thin bony cortex (HP:0002753)2.24752502
62Duplication of thumb phalanx (HP:0009942)2.22009357
63Rib fusion (HP:0000902)2.19845339
64Abnormality of the 4th metacarpal (HP:0010012)2.19561038
65Myopathic facies (HP:0002058)2.19557919
66Cholecystitis (HP:0001082)2.19131623
67Abnormal gallbladder physiology (HP:0012438)2.19131623
68Elfin facies (HP:0004428)2.18949180
69Duplicated collecting system (HP:0000081)2.18920376
70High pitched voice (HP:0001620)2.16128578
71Myelodysplasia (HP:0002863)2.14350644
72Neoplasm of striated muscle (HP:0009728)2.12513713
73Nephroblastoma (Wilms tumor) (HP:0002667)2.10837334
74Facial hemangioma (HP:0000329)2.10575906
75Basal cell carcinoma (HP:0002671)2.10348048
76Heterotopia (HP:0002282)2.10094189
77Abnormality of the musculature of the pelvis (HP:0001469)2.09370572
78Abnormality of the hip-girdle musculature (HP:0001445)2.09370572
79Ragged-red muscle fibers (HP:0003200)2.06584784
80Abnormality of the preputium (HP:0100587)2.06513695
81Deep philtrum (HP:0002002)2.05491102
82Broad face (HP:0000283)2.04346130
83Capillary hemangiomas (HP:0005306)2.04093216
84Morphological abnormality of the inner ear (HP:0011390)2.03836961
85Small intestinal stenosis (HP:0012848)2.02924919
86Duodenal stenosis (HP:0100867)2.02924919
87Abnormal number of incisors (HP:0011064)2.00972076
88Overriding aorta (HP:0002623)2.00645773
89Obsessive-compulsive behavior (HP:0000722)1.99756674
90Deep palmar crease (HP:0006191)1.99599683
91Sandal gap (HP:0001852)1.98537128
92Cafe-au-lait spot (HP:0000957)1.98497421
93Seborrheic dermatitis (HP:0001051)1.98015256
94Acute lymphatic leukemia (HP:0006721)1.97630561
95Broad thumb (HP:0011304)1.97176647
96Embryonal renal neoplasm (HP:0011794)1.96858821
97Hypertensive crisis (HP:0100735)1.96807206
98Dysmetric saccades (HP:0000641)1.95769823
99Broad palm (HP:0001169)1.94690682
100Atresia of the external auditory canal (HP:0000413)1.93526115
101Aplasia/Hypoplasia of the earlobes (HP:0009906)1.92373370
102Annular pancreas (HP:0001734)1.91843801
103Breast hypoplasia (HP:0003187)1.91600837
104Progressive external ophthalmoplegia (HP:0000590)1.91396313
105Hypoparathyroidism (HP:0000829)1.90205701
106Bowel diverticulosis (HP:0005222)1.89935603
107Abnormally folded helix (HP:0008544)1.88859076
108Neoplasm of the pancreas (HP:0002894)1.88034432
109Spina bifida occulta (HP:0003298)1.87467289
110Gastrointestinal carcinoma (HP:0002672)1.86753030
111Malignant gastrointestinal tract tumors (HP:0006749)1.86753030
112Distal upper limb amyotrophy (HP:0007149)1.86498452
113Upper limb amyotrophy (HP:0009129)1.86498452
114Shoulder girdle muscle weakness (HP:0003547)1.86174862
115Absent thumb (HP:0009777)1.85923010
116Pointed chin (HP:0000307)1.85825619
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.85682166
118Diastasis recti (HP:0001540)1.85564833
119Biliary tract neoplasm (HP:0100574)1.85233529
120Broad phalanges of the hand (HP:0009768)1.83294201
121Long palpebral fissure (HP:0000637)1.82656251
122Missing ribs (HP:0000921)1.82460314
123Supernumerary bones of the axial skeleton (HP:0009144)1.82161427
124Supernumerary ribs (HP:0005815)1.81845355
125Sloping forehead (HP:0000340)1.81599287
126Amaurosis fugax (HP:0100576)1.81076271
127Broad distal phalanx of finger (HP:0009836)1.80962038
128Fragile skin (HP:0001030)1.79586188
129Skin tags (HP:0010609)1.79061568
130Abnormality of the diencephalon (HP:0010662)1.78224019
131Abnormality of the tricuspid valve (HP:0001702)1.77273996
132Rectal fistula (HP:0100590)1.77078767
133Rectovaginal fistula (HP:0000143)1.77078767
134Vaginal fistula (HP:0004320)1.77075553
135Trigonocephaly (HP:0000243)1.76761503
136Abnormality of the duodenum (HP:0002246)1.76441073
137Overlapping toe (HP:0001845)1.76093336
138Tracheoesophageal fistula (HP:0002575)1.75531093
139Abnormality of the renal collecting system (HP:0004742)1.74788758
140Abnormality of homocysteine metabolism (HP:0010919)1.74383257
141Homocystinuria (HP:0002156)1.74383257
142Flat cornea (HP:0007720)1.74278362
143Abnormality of oral frenula (HP:0000190)1.74207691
144Short thumb (HP:0009778)1.74130462
145Abnormality of the phalanges of the hallux (HP:0010057)1.72660521
146Increased density of long bones (HP:0006392)1.71057666
147Ileus (HP:0002595)1.71023301
148Shallow orbits (HP:0000586)1.70955836
149Intestinal malrotation (HP:0002566)1.70954657
150Supernumerary spleens (HP:0009799)1.70892823
15111 pairs of ribs (HP:0000878)1.70861008
152Abnormality of the lower motor neuron (HP:0002366)1.70687733
153Truncal obesity (HP:0001956)1.70645563
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70520923
155High anterior hairline (HP:0009890)1.69837298
156Flared metaphyses (HP:0003015)1.69003513
157Absent radius (HP:0003974)1.68959521
158Abnormality of chromosome segregation (HP:0002916)1.68479941
159Preauricular skin tag (HP:0000384)1.68007984
160Microtia (HP:0008551)1.67968249
161Slender long bone (HP:0003100)1.67915611
162Abnormality of the calcaneus (HP:0008364)1.67096961
163Cheekbone underdevelopment (HP:0010669)1.66485397
164Reticulocytopenia (HP:0001896)1.66469247
165Stridor (HP:0010307)1.66371997
166Cutis marmorata (HP:0000965)1.66239873
167Megalocornea (HP:0000485)1.66012783
168Subacute progressive viral hepatitis (HP:0006572)1.65462327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.07419689
2TRIB34.53222274
3NEK13.99880413
4NEK23.81416693
5CDK123.58171392
6SMG13.17235963
7WEE12.77371533
8SRPK12.73932419
9PLK42.52309285
10TTK2.29181814
11MAP3K102.22383120
12BUB12.21226739
13ATR2.16769748
14EEF2K2.09950573
15BRD42.03811794
16ACVR1B1.86271241
17MKNK11.81772383
18KSR21.77140221
19PLK11.76267279
20TSSK61.75781256
21SIK11.73983374
22PRPF4B1.71976735
23CHEK21.66153347
24DYRK31.65997037
25AURKB1.64451948
26PASK1.59148953
27CDK41.58869200
28CDK71.57959566
29ZAK1.53901618
30CHEK11.53248007
31RPS6KB21.52099177
32MKNK21.50502615
33PLK31.46915216
34MAPK151.40093545
35PKN21.39923949
36SCYL21.32557980
37STK41.28437869
38LATS11.27085436
39EIF2AK11.26892783
40ATM1.23905587
41MAP3K81.22373926
42MAP2K61.21373875
43CDK61.18874803
44FGFR41.17096740
45MAPK111.17043109
46STK101.16980814
47RPS6KA41.14590538
48RIPK41.14100634
49WNK41.13494043
50CDK21.13375762
51TLK11.13001534
52ALK1.12435780
53CCNB11.09910016
54IRAK31.08358641
55BMX1.05860085
56BRSK21.03835071
57CDK81.02783975
58WNK10.99412909
59SIK20.96328664
60PAK40.95368191
61STK30.94776902
62CDK10.94610357
63MTOR0.89941411
64MAP3K70.88657795
65MELK0.85829113
66BRSK10.85320353
67PIM10.85029046
68RAF10.83959086
69NME10.83764531
70TGFBR10.83143186
71TRPM70.82591029
72EPHA20.81167037
73MARK20.81025624
74PDGFRA0.80930829
75CAMK1D0.79260326
76PTK60.77520710
77ERBB30.77096616
78VRK10.75843021
79AURKA0.74879207
80MAP3K130.74392692
81PRKDC0.69374360
82AKT20.68056911
83ICK0.66467130
84CLK10.65715068
85TTN0.65271160
86MAP4K10.64902661
87PRKAA10.64665112
88FGFR10.64319483
89RIPK10.64059855
90YES10.58633706
91PRKD20.58465457
92CDK90.57976819
93RPS6KA20.55296537
94MAPK140.55207319
95ERN10.54072438
96RPS6KB10.53680516
97PDPK10.52771911
98PAK20.52583482
99BRAF0.52568222
100NME20.52480823
101MST1R0.52369012
102TAOK20.52067909
103CDK190.51009103
104HIPK20.49962688
105RPS6KC10.49840239
106RPS6KL10.49840239
107CAMK1G0.49571876
108RET0.47920037
109CSNK2A20.46734207
110CSNK1E0.45476769
111GSK3B0.45016981
112CSNK1D0.44005723
113DAPK10.43593512
114EIF2AK30.43187006
115PNCK0.42844922
116AKT10.42564321
117FGFR20.39946108
118MET0.39579701
119TYRO30.38756824
120RPS6KA10.37543493
121CDK11A0.37294631
122PDGFRB0.36766438
123MAP3K90.35629070
124PLK20.34129057
125MAP3K50.34086470
126PRKCI0.33624182
127MAPK100.32773559
128LRRK20.30315779
129MAPK10.29783308
130TESK20.29768816
131CSNK2A10.29485119
132MAP2K30.28983446
133MAPK80.27374549
134MAPK90.27254658
135KSR10.26918660
136LATS20.26816450
137PRKD30.26493305
138CDC42BPA0.21611872

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51097045
2Mismatch repair_Homo sapiens_hsa034303.90899074
3Cell cycle_Homo sapiens_hsa041103.06132503
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02786552
5Spliceosome_Homo sapiens_hsa030402.97925764
6RNA transport_Homo sapiens_hsa030132.95784743
7Base excision repair_Homo sapiens_hsa034102.82643319
8Homologous recombination_Homo sapiens_hsa034402.50111226
9Fanconi anemia pathway_Homo sapiens_hsa034602.39715600
10One carbon pool by folate_Homo sapiens_hsa006702.39492110
11mRNA surveillance pathway_Homo sapiens_hsa030152.34802464
12Nucleotide excision repair_Homo sapiens_hsa034202.25480749
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05133957
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86919640
15Sulfur relay system_Homo sapiens_hsa041221.85438576
16Systemic lupus erythematosus_Homo sapiens_hsa053221.82758895
17Non-homologous end-joining_Homo sapiens_hsa034501.78977746
18RNA degradation_Homo sapiens_hsa030181.76865531
19p53 signaling pathway_Homo sapiens_hsa041151.63040880
20Fructose and mannose metabolism_Homo sapiens_hsa000511.48408740
21RNA polymerase_Homo sapiens_hsa030201.46901705
22Viral carcinogenesis_Homo sapiens_hsa052031.44254424
23MicroRNAs in cancer_Homo sapiens_hsa052061.44233161
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43255716
25Pyrimidine metabolism_Homo sapiens_hsa002401.36158067
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33552214
27Oocyte meiosis_Homo sapiens_hsa041141.31950704
28VEGF signaling pathway_Homo sapiens_hsa043701.17757040
29HTLV-I infection_Homo sapiens_hsa051661.17636120
30Basal transcription factors_Homo sapiens_hsa030221.17301641
31Alcoholism_Homo sapiens_hsa050341.13158428
32Epstein-Barr virus infection_Homo sapiens_hsa051691.11174546
33Other glycan degradation_Homo sapiens_hsa005111.08837993
34Colorectal cancer_Homo sapiens_hsa052101.07757888
35Herpes simplex infection_Homo sapiens_hsa051681.06593377
36Insulin signaling pathway_Homo sapiens_hsa049101.06057884
37Lysine degradation_Homo sapiens_hsa003101.05887312
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05261768
39Small cell lung cancer_Homo sapiens_hsa052221.04307930
40Basal cell carcinoma_Homo sapiens_hsa052171.02208660
41Chronic myeloid leukemia_Homo sapiens_hsa052200.98891431
42Inositol phosphate metabolism_Homo sapiens_hsa005620.89430497
43Renal cell carcinoma_Homo sapiens_hsa052110.88948733
44Ribosome_Homo sapiens_hsa030100.88930524
45mTOR signaling pathway_Homo sapiens_hsa041500.86380504
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84073890
47Hippo signaling pathway_Homo sapiens_hsa043900.83841277
48Antigen processing and presentation_Homo sapiens_hsa046120.83274725
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83023253
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.77639293
51Type II diabetes mellitus_Homo sapiens_hsa049300.76520870
52Non-small cell lung cancer_Homo sapiens_hsa052230.73933533
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73724459
54Adherens junction_Homo sapiens_hsa045200.73684922
55Purine metabolism_Homo sapiens_hsa002300.73090572
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72322970
57Notch signaling pathway_Homo sapiens_hsa043300.71021828
58Prolactin signaling pathway_Homo sapiens_hsa049170.70381505
59Hedgehog signaling pathway_Homo sapiens_hsa043400.70291477
60Endometrial cancer_Homo sapiens_hsa052130.69806759
61Proteasome_Homo sapiens_hsa030500.66817345
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66645516
63Thyroid cancer_Homo sapiens_hsa052160.66140535
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65979199
65Viral myocarditis_Homo sapiens_hsa054160.65886152
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.65850941
67Hepatitis B_Homo sapiens_hsa051610.65833966
68Choline metabolism in cancer_Homo sapiens_hsa052310.65484129
69TGF-beta signaling pathway_Homo sapiens_hsa043500.65173522
70Proteoglycans in cancer_Homo sapiens_hsa052050.64457601
71Steroid biosynthesis_Homo sapiens_hsa001000.64241614
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63596233
73Estrogen signaling pathway_Homo sapiens_hsa049150.63005613
74Pathways in cancer_Homo sapiens_hsa052000.61873972
75Wnt signaling pathway_Homo sapiens_hsa043100.61281187
76Insulin resistance_Homo sapiens_hsa049310.60600480
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.59665641
78Primary immunodeficiency_Homo sapiens_hsa053400.59528884
79GnRH signaling pathway_Homo sapiens_hsa049120.58387046
80Pancreatic cancer_Homo sapiens_hsa052120.57900055
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57750663
82Apoptosis_Homo sapiens_hsa042100.57101393
83Prostate cancer_Homo sapiens_hsa052150.56230115
84Prion diseases_Homo sapiens_hsa050200.56052931
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55945815
86Pentose phosphate pathway_Homo sapiens_hsa000300.54752544
87Selenocompound metabolism_Homo sapiens_hsa004500.54160868
88Carbon metabolism_Homo sapiens_hsa012000.52837429
89B cell receptor signaling pathway_Homo sapiens_hsa046620.51553649
90Glioma_Homo sapiens_hsa052140.51264508
91T cell receptor signaling pathway_Homo sapiens_hsa046600.51122782
92Melanogenesis_Homo sapiens_hsa049160.51071225
93FoxO signaling pathway_Homo sapiens_hsa040680.50550921
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.49706774
95HIF-1 signaling pathway_Homo sapiens_hsa040660.49691485
96Measles_Homo sapiens_hsa051620.49170407
97Acute myeloid leukemia_Homo sapiens_hsa052210.47599961
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.46716798
99N-Glycan biosynthesis_Homo sapiens_hsa005100.46309777
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45561063
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.44743307
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44379208
103Melanoma_Homo sapiens_hsa052180.44304516
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44198214
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42143543
106Gap junction_Homo sapiens_hsa045400.41923582
107Focal adhesion_Homo sapiens_hsa045100.41121541
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40641128
109Shigellosis_Homo sapiens_hsa051310.39383742
110Influenza A_Homo sapiens_hsa051640.39233447
111Fatty acid biosynthesis_Homo sapiens_hsa000610.39031620
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38825385
113Glucagon signaling pathway_Homo sapiens_hsa049220.38445340
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38395582
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38046207
116Bladder cancer_Homo sapiens_hsa052190.37812076
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.36829632
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34702839
119ErbB signaling pathway_Homo sapiens_hsa040120.34092295
120Tight junction_Homo sapiens_hsa045300.31300498
121Legionellosis_Homo sapiens_hsa051340.30469493
122Platelet activation_Homo sapiens_hsa046110.29743680
123Biosynthesis of amino acids_Homo sapiens_hsa012300.29559188
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28636155
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28599721
126Rap1 signaling pathway_Homo sapiens_hsa040150.27924390
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26865956
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25812423
129AMPK signaling pathway_Homo sapiens_hsa041520.24944207
130MAPK signaling pathway_Homo sapiens_hsa040100.24836829
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23741869
132Renin-angiotensin system_Homo sapiens_hsa046140.23013133

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »