DGKA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.80200020
2positive regulation of gamma-delta T cell activation (GO:0046645)7.75472341
3negative thymic T cell selection (GO:0045060)7.51857908
4positive thymic T cell selection (GO:0045059)7.18123393
5negative regulation of cell killing (GO:0031342)7.14833751
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.14833751
7positive T cell selection (GO:0043368)6.87740672
8regulation of gamma-delta T cell differentiation (GO:0045586)6.78573435
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.74554812
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.74554812
11thymic T cell selection (GO:0045061)6.72083401
12regulation of T cell tolerance induction (GO:0002664)6.63540381
13T cell selection (GO:0045058)6.57968498
14regulation of isotype switching to IgG isotypes (GO:0048302)6.49658875
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46215453
16regulation of gamma-delta T cell activation (GO:0046643)6.15729233
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.95855317
18antigen processing and presentation of endogenous antigen (GO:0019883)5.84375814
19interferon-gamma production (GO:0032609)5.72653102
20T cell migration (GO:0072678)5.56094798
21response to interleukin-15 (GO:0070672)5.55779767
22T cell receptor signaling pathway (GO:0050852)5.49888808
23positive regulation of tolerance induction (GO:0002645)5.40592269
24regulation of regulatory T cell differentiation (GO:0045589)5.18301393
25cellular response to interleukin-15 (GO:0071350)5.08121000
26T cell costimulation (GO:0031295)5.02042137
27leukocyte aggregation (GO:0070486)4.97464650
28lymphocyte costimulation (GO:0031294)4.93223754
29regulation of tolerance induction (GO:0002643)4.85288655
30regulation of interleukin-2 biosynthetic process (GO:0045076)4.74029454
31tolerance induction (GO:0002507)4.72489025
32antigen receptor-mediated signaling pathway (GO:0050851)4.58531176
33positive regulation of granulocyte differentiation (GO:0030854)4.58503619
34positive regulation of interleukin-2 production (GO:0032743)4.43093134
35negative regulation of T cell mediated immunity (GO:0002710)4.40368963
36regulation of alpha-beta T cell proliferation (GO:0046640)4.37903988
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.09848690
38activated T cell proliferation (GO:0050798)4.07774844
39regulation of T cell receptor signaling pathway (GO:0050856)4.06231118
40regulation of interleukin-12 biosynthetic process (GO:0045075)4.00745273
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.92503225
42alpha-beta T cell activation (GO:0046631)3.92231984
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.91122774
44regulation of isotype switching (GO:0045191)3.90682252
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89654280
46alpha-beta T cell differentiation (GO:0046632)3.82882226
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.78625627
48positive regulation of isotype switching (GO:0045830)3.76538264
49regulation of B cell receptor signaling pathway (GO:0050855)3.75585303
50regulation of response to interferon-gamma (GO:0060330)3.68039466
51regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.65233846
52regulation of type I interferon-mediated signaling pathway (GO:0060338)3.63515815
53NIK/NF-kappaB signaling (GO:0038061)3.61892899
54T cell differentiation (GO:0030217)3.61381290
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.54774469
56detection of bacterium (GO:0016045)3.54378841
57heterotypic cell-cell adhesion (GO:0034113)3.52721260
58regulation of T cell mediated cytotoxicity (GO:0001914)3.51987996
59positive regulation of humoral immune response (GO:0002922)3.47707204
60detection of other organism (GO:0098543)3.45381106
61negative regulation of leukocyte mediated immunity (GO:0002704)3.44925959
62regulation of interleukin-2 production (GO:0032663)3.43367910
63mast cell activation (GO:0045576)3.39502221
64T cell homeostasis (GO:0043029)3.38630643
65leukocyte cell-cell adhesion (GO:0007159)3.31689512
66modulation by symbiont of host immune response (GO:0052553)3.31562995
67positive regulation by symbiont of host defense response (GO:0052509)3.31562995
68modulation by symbiont of host defense response (GO:0052031)3.31562995
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31562995
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31562995
71positive regulation by organism of defense response of other organism involved in symbiotic interact3.31562995
72positive regulation of B cell differentiation (GO:0045579)3.30273023
73natural killer cell activation (GO:0030101)3.30141001
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28611040
75regulation of natural killer cell mediated immunity (GO:0002715)3.28611040
76regulation of granulocyte differentiation (GO:0030852)3.28100570
77response to type I interferon (GO:0034340)3.26434997
78regulation of immunoglobulin mediated immune response (GO:0002889)3.24741645
79immune response-activating cell surface receptor signaling pathway (GO:0002429)3.24044277
80T cell activation (GO:0042110)3.23004765
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22596465
82positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21321164
83positive regulation of DNA recombination (GO:0045911)3.21226215
84sequestering of actin monomers (GO:0042989)3.21116320
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19981947
86positive regulation of interleukin-4 production (GO:0032753)3.19659880
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.18155711
88antigen processing and presentation via MHC class Ib (GO:0002475)3.16933458
89regulation of defense response to virus by virus (GO:0050690)3.16575560
90positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.15883648
91positive regulation of natural killer cell mediated immunity (GO:0002717)3.15883648
92regulation of B cell mediated immunity (GO:0002712)3.15768910
93cellular response to type I interferon (GO:0071357)3.15729034
94type I interferon signaling pathway (GO:0060337)3.15729034
95response to muramyl dipeptide (GO:0032495)3.15340348
96mast cell degranulation (GO:0043303)3.14828528
97mast cell activation involved in immune response (GO:0002279)3.14828528
98lymphocyte migration (GO:0072676)3.11728804
99regulation of B cell differentiation (GO:0045577)3.10250505
100regulation of leukocyte mediated cytotoxicity (GO:0001910)3.09925988
101lymph node development (GO:0048535)3.09385981
102negative regulation of T-helper cell differentiation (GO:0045623)3.08861431
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08861431
104regulation of immunoglobulin production (GO:0002637)3.07616283
105positive regulation of T cell differentiation in thymus (GO:0033089)3.06362197
106positive regulation of immunoglobulin mediated immune response (GO:0002891)3.05557774
107positive regulation of B cell mediated immunity (GO:0002714)3.05557774
108B cell receptor signaling pathway (GO:0050853)3.05381185
109Peyers patch development (GO:0048541)3.04125302
110mucosal-associated lymphoid tissue development (GO:0048537)3.04125302
111positive regulation of T cell activation (GO:0050870)3.03368644
112neutrophil activation involved in immune response (GO:0002283)3.03072955
113regulation of interleukin-4 production (GO:0032673)3.00242752
114regulation of alpha-beta T cell activation (GO:0046634)2.99865630
115natural killer cell differentiation (GO:0001779)2.98632309
116V(D)J recombination (GO:0033151)2.97517914
117positive regulation of T cell differentiation (GO:0045582)2.96333118
118lymphocyte homeostasis (GO:0002260)2.95972507
119T cell proliferation (GO:0042098)2.95948931
120hepatocyte apoptotic process (GO:0097284)2.95418131
121endothelial tube morphogenesis (GO:0061154)2.94322703
122morphogenesis of an endothelium (GO:0003159)2.94322703
123negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93082409
124positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92311168
125B cell homeostasis (GO:0001782)2.91385744
126cellular extravasation (GO:0045123)2.89429879
127T-helper cell differentiation (GO:0042093)2.89415598
128CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.89415598
129negative regulation of adaptive immune response (GO:0002820)2.88980886
130positive regulation of alpha-beta T cell activation (GO:0046635)2.88516736
131histone H3-K36 demethylation (GO:0070544)2.87050443
132regulation of cell killing (GO:0031341)2.86872106
133negative regulation of interleukin-12 production (GO:0032695)2.85041955
134negative regulation of innate immune response (GO:0045824)2.82018414
135regulation of antigen processing and presentation (GO:0002577)2.81673571
136positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80829444
137positive regulation of alpha-beta T cell differentiation (GO:0046638)2.79966762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.71858066
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.89859741
3* IRF8_22096565_ChIP-ChIP_GC-B_Human3.85698430
4MYC_22102868_ChIP-Seq_BL_Human3.73607683
5FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.72979476
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.60915153
7* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58260745
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.58058167
9* RUNX_20019798_ChIP-Seq_JUKART_Human3.57607682
10* MYB_26560356_Chip-Seq_TH2_Human3.19786963
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.05787848
12* MAF_26560356_Chip-Seq_TH1_Human3.04781514
13* UTX_26944678_Chip-Seq_JUKART_Human2.83677417
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83119865
15* MYB_26560356_Chip-Seq_TH1_Human2.79542614
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.58034394
17VDR_21846776_ChIP-Seq_THP-1_Human2.57022817
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46756389
19* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38069106
20MAF_26560356_Chip-Seq_TH2_Human2.27125841
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25551631
22TCF7_22412390_ChIP-Seq_EML_Mouse2.18951970
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17710016
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.13765374
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.13749175
26E2F7_22180533_ChIP-Seq_HELA_Human2.08068730
27* GATA3_27048872_Chip-Seq_THYMUS_Human2.07437667
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05216832
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.96592534
30KDM2B_26808549_Chip-Seq_DND41_Human1.94048314
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91735650
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90982098
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86789117
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85678264
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.76728146
36SPI1_23547873_ChIP-Seq_NB4_Human1.73583275
37VDR_24763502_ChIP-Seq_THP-1_Human1.72558762
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.71809059
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68282068
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65879225
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65338080
42VDR_24787735_ChIP-Seq_THP-1_Human1.59183870
43SCL_19346495_ChIP-Seq_HPC-7_Human1.59076215
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57334289
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56848256
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52071087
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47455974
48CIITA_25753668_ChIP-Seq_RAJI_Human1.46112232
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.45868242
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41318976
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38857525
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34534256
53SPI1_23127762_ChIP-Seq_K562_Human1.34064325
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29617977
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29216897
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.25732743
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20818118
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20631910
59GATA3_26560356_Chip-Seq_TH2_Human1.18151887
60* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16237505
61* PU_27001747_Chip-Seq_BMDM_Mouse1.14418626
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13751715
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.13406812
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12726908
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11537502
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09440703
67* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09188689
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07804193
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06798131
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06676505
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06633999
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06621228
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06295032
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01908295
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01093586
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01072931
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00239694
78NCOR1_26117541_ChIP-Seq_K562_Human1.00156522
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98594100
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96681661
81* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96314303
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91575693
83SMAD_19615063_ChIP-ChIP_OVARY_Human0.90329496
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88802292
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.88665805
86GATA1_22025678_ChIP-Seq_K562_Human0.88313464
87* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88228140
88BCOR_27268052_Chip-Seq_Bcells_Human0.85481340
89* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84511706
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83492620
91* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83441247
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82765847
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82174276
94* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79595666
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.79486409
96SMRT_27268052_Chip-Seq_Bcells_Human0.79483930
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79379528
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79358141
99VDR_23849224_ChIP-Seq_CD4+_Human0.78920958
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78013533
101LXR_22292898_ChIP-Seq_THP-1_Human0.77886498
102* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77243345
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77024047
104SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76362526
105FOXP3_21729870_ChIP-Seq_TREG_Human0.75990193
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75147765
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74450651
108GATA3_26560356_Chip-Seq_TH1_Human0.74354248
109RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74127920
110* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73335414
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.73001290
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72380981
113RACK7_27058665_Chip-Seq_MCF-7_Human0.71564657
114P300_27268052_Chip-Seq_Bcells_Human0.71011672
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70643310
116GATA2_19941826_ChIP-Seq_K562_Human0.70254563
117BCL6_27268052_Chip-Seq_Bcells_Human0.69763866
118GATA1_19941826_ChIP-Seq_K562_Human0.69478851
119* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69427181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003763_abnormal_thymus_physiology5.52881866
2MP0005671_abnormal_response_to3.99653618
3MP0000685_abnormal_immune_system3.70997121
4MP0002166_altered_tumor_susceptibility3.30260234
5MP0001835_abnormal_antigen_presentation3.26127724
6MP0001800_abnormal_humoral_immune3.18423056
7MP0001790_abnormal_immune_system3.09396012
8MP0005387_immune_system_phenotype3.09396012
9MP0001873_stomach_inflammation2.99437569
10* MP0002398_abnormal_bone_marrow2.74368409
11* MP0002420_abnormal_adaptive_immunity2.74278723
12* MP0001819_abnormal_immune_cell2.70292237
13* MP0002723_abnormal_immune_serum2.68372471
14MP0000703_abnormal_thymus_morphology2.65362766
15MP0002006_tumorigenesis2.63063979
16* MP0005000_abnormal_immune_tolerance2.62107391
17MP0009333_abnormal_splenocyte_physiolog2.59886840
18MP0003866_abnormal_defecation2.57789304
19MP0002452_abnormal_antigen_presenting2.52545349
20MP0010155_abnormal_intestine_physiology2.48228232
21MP0004947_skin_inflammation2.47048376
22* MP0000716_abnormal_immune_system2.39933547
23MP0002405_respiratory_system_inflammati2.39886606
24MP0009785_altered_susceptibility_to2.39067299
25MP0002722_abnormal_immune_system2.31010888
26MP0005025_abnormal_response_to2.28485936
27MP0002396_abnormal_hematopoietic_system2.24772073
28MP0003300_gastrointestinal_ulcer2.21466311
29MP0003436_decreased_susceptibility_to2.21306402
30MP0000689_abnormal_spleen_morphology2.18518246
31MP0006082_CNS_inflammation2.07191209
32* MP0002429_abnormal_blood_cell1.93215551
33MP0002148_abnormal_hypersensitivity_rea1.81208597
34MP0003724_increased_susceptibility_to1.75195474
35MP0002933_joint_inflammation1.67593598
36MP0002009_preneoplasia1.67204927
37MP0000465_gastrointestinal_hemorrhage1.66495160
38MP0001845_abnormal_inflammatory_respons1.65126544
39MP0002419_abnormal_innate_immunity1.64512487
40MP0004808_abnormal_hematopoietic_stem1.62796176
41MP0005464_abnormal_platelet_physiology1.59584195
42MP0010352_gastrointestinal_tract_polyps1.54456271
43MP0003303_peritoneal_inflammation1.49961717
44MP0003191_abnormal_cellular_cholesterol1.46735920
45MP0005310_abnormal_salivary_gland1.46202769
46MP0004510_myositis1.39150906
47MP0004381_abnormal_hair_follicle1.38546308
48MP0010234_abnormal_vibrissa_follicle1.33432057
49MP0001853_heart_inflammation1.32428184
50MP0000858_altered_metastatic_potential1.27890973
51MP0003172_abnormal_lysosome_physiology1.27019482
52MP0000490_abnormal_crypts_of1.26114606
53MP0008260_abnormal_autophagy1.23316259
54MP0003828_pulmonary_edema1.20689949
55MP0008961_abnormal_basal_metabolism1.14503471
56MP0001851_eye_inflammation1.13177155
57MP0005023_abnormal_wound_healing1.10521100
58MP0003453_abnormal_keratinocyte_physiol1.09789874
59MP0009278_abnormal_bone_marrow1.05603471
60MP0005397_hematopoietic_system_phenotyp1.04989618
61MP0001545_abnormal_hematopoietic_system1.04989618
62MP0003183_abnormal_peptide_metabolism1.03591746
63MP0002019_abnormal_tumor_incidence1.03535063
64MP0008469_abnormal_protein_level1.02064742
65MP0004185_abnormal_adipocyte_glucose0.99110187
66MP0003448_altered_tumor_morphology0.98963370
67MP0003045_fibrosis0.97190737
68MP0002138_abnormal_hepatobiliary_system0.93999642
69MP0005451_abnormal_body_composition0.93960091
70MP0005075_abnormal_melanosome_morpholog0.91443200
71MP0004883_abnormal_blood_vessel0.90714939
72MP0002132_abnormal_respiratory_system0.90492609
73MP0001533_abnormal_skeleton_physiology0.90190192
74MP0001986_abnormal_taste_sensitivity0.88010589
75MP0001216_abnormal_epidermal_layer0.80849695
76MP0005076_abnormal_cell_differentiation0.78886985
77MP0000015_abnormal_ear_pigmentation0.78885492
78MP0001501_abnormal_sleep_pattern0.77650975
79MP0002277_abnormal_respiratory_mucosa0.76837516
80MP0000477_abnormal_intestine_morphology0.75274816
81MP0005390_skeleton_phenotype0.73398999
82MP0002822_catalepsy0.72810909
83MP0000249_abnormal_blood_vessel0.71028536
84MP0004130_abnormal_muscle_cell0.69504852
85MP0009765_abnormal_xenobiotic_induced0.68066923
86MP0003566_abnormal_cell_adhesion0.67891178
87MP0003077_abnormal_cell_cycle0.67828111
88MP0001765_abnormal_ion_homeostasis0.67706546
89MP0002998_abnormal_bone_remodeling0.66872521
90MP0001663_abnormal_digestive_system0.64544804
91MP0005164_abnormal_response_to0.63837101
92MP0001348_abnormal_lacrimal_gland0.63635798
93MP0005166_decreased_susceptibility_to0.62943172
94MP0000604_amyloidosis0.62514523
95MP0004264_abnormal_extraembryonic_tissu0.62290713
96MP0001243_abnormal_dermal_layer0.62030500
97MP0002136_abnormal_kidney_physiology0.62020608
98MP0008057_abnormal_DNA_replication0.61328760
99MP0001191_abnormal_skin_condition0.61159126
100MP0003091_abnormal_cell_migration0.60895018
101MP0002796_impaired_skin_barrier0.60662350
102MP0009840_abnormal_foam_cell0.60628187
103MP0000609_abnormal_liver_physiology0.59799217
104MP0002693_abnormal_pancreas_physiology0.59216917
105MP0009763_increased_sensitivity_to0.59093825
106MP0005501_abnormal_skin_physiology0.56965529
107MP0009764_decreased_sensitivity_to0.56079237
108MP0005174_abnormal_tail_pigmentation0.51395824
109MP0003279_aneurysm0.51155081
110MP0009931_abnormal_skin_appearance0.50746222
111MP0005381_digestive/alimentary_phenotyp0.50165970
112MP0008874_decreased_physiological_sensi0.50141261
113MP0005670_abnormal_white_adipose0.50012026
114MP0000367_abnormal_coat/_hair0.48836987
115MP0003656_abnormal_erythrocyte_physiolo0.48267155
116MP0000377_abnormal_hair_follicle0.46587088
117MP0003795_abnormal_bone_structure0.45604674
118MP0003252_abnormal_bile_duct0.45267432
119MP0009115_abnormal_fat_cell0.45209770
120MP0003868_abnormal_feces_composition0.44895810
121MP0004484_altered_response_of0.44196910
122MP0003693_abnormal_embryo_hatching0.43821335
123MP0000383_abnormal_hair_follicle0.41507337
124MP0000313_abnormal_cell_death0.41183638
125MP0004957_abnormal_blastocyst_morpholog0.40687622
126MP0000350_abnormal_cell_proliferation0.40135240
127MP0005666_abnormal_adipose_tissue0.39221123

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.86971699
2Abnormality of T cell number (HP:0011839)7.55926504
3Abnormality of T cells (HP:0002843)5.35687075
4Recurrent bronchitis (HP:0002837)5.31192364
5Severe combined immunodeficiency (HP:0004430)5.25349682
6Elevated erythrocyte sedimentation rate (HP:0003565)5.03659096
7Combined immunodeficiency (HP:0005387)5.03058168
8Pustule (HP:0200039)4.95114744
9Nasal polyposis (HP:0100582)4.82983216
10Recurrent viral infections (HP:0004429)4.79130977
11Autoimmune hemolytic anemia (HP:0001890)4.75745178
12Chronic otitis media (HP:0000389)4.70132871
13Panhypogammaglobulinemia (HP:0003139)4.67860713
14Recurrent fungal infections (HP:0002841)4.60543440
15Abnormality of the fingertips (HP:0001211)4.35260712
16IgM deficiency (HP:0002850)4.30875836
17Recurrent bacterial skin infections (HP:0005406)4.23007656
18Abnormality of the nasal mucosa (HP:0000433)4.16925381
19Stomatitis (HP:0010280)4.16353282
20IgG deficiency (HP:0004315)4.06255752
21Chronic mucocutaneous candidiasis (HP:0002728)4.04017600
22Recurrent cutaneous fungal infections (HP:0011370)4.04017600
23Abnormality of eosinophils (HP:0001879)3.99036782
24Eosinophilia (HP:0001880)3.98204431
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.94427852
26B lymphocytopenia (HP:0010976)3.87066624
27Abnormality of B cell number (HP:0010975)3.87066624
28Autoimmune thrombocytopenia (HP:0001973)3.78756641
29Thyroiditis (HP:0100646)3.75608339
30Chronic diarrhea (HP:0002028)3.69767700
31Lymphopenia (HP:0001888)3.55444111
32Granulocytopenia (HP:0001913)3.51132126
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.43673780
34Leukocytosis (HP:0001974)3.31155326
35Abnormality of macrophages (HP:0004311)3.30968981
36Basal cell carcinoma (HP:0002671)3.23165607
37Abnormality of T cell physiology (HP:0011840)3.21575535
38Bronchitis (HP:0012387)3.20584505
39Eczematoid dermatitis (HP:0000976)3.20448130
40Papilledema (HP:0001085)3.19798401
41Increased IgM level (HP:0003496)3.18465453
42Myositis (HP:0100614)3.17003706
43Verrucae (HP:0200043)3.13973338
44Papilloma (HP:0012740)3.13973338
45Agammaglobulinemia (HP:0004432)3.08859893
46Hypoplasia of the thymus (HP:0000778)3.07717089
47Inflammation of the large intestine (HP:0002037)3.06828548
48Increased IgE level (HP:0003212)3.05499444
49Gastrointestinal inflammation (HP:0004386)3.00752976
50Recurrent sinusitis (HP:0011108)2.96124379
51Spontaneous hematomas (HP:0007420)2.85530786
52Joint swelling (HP:0001386)2.84412237
53Keratoconjunctivitis sicca (HP:0001097)2.78788121
54Vasculitis (HP:0002633)2.70019857
55Chronic sinusitis (HP:0011109)2.69091962
56Hypergammaglobulinemia (HP:0010702)2.65220055
57Keratoconjunctivitis (HP:0001096)2.64925772
58IgA deficiency (HP:0002720)2.61879715
59Meningitis (HP:0001287)2.61478798
60Recurrent otitis media (HP:0000403)2.56129404
61Lymphoma (HP:0002665)2.53730197
62Gingivitis (HP:0000230)2.52561525
63Cheilitis (HP:0100825)2.44628699
64Hemoptysis (HP:0002105)2.43208985
65Ureteral stenosis (HP:0000071)2.39676379
66Stomach cancer (HP:0012126)2.37971903
67Thrombocytosis (HP:0001894)2.36935963
68Colitis (HP:0002583)2.36304787
69Milia (HP:0001056)2.35771305
70Bronchiectasis (HP:0002110)2.35759253
71Urticaria (HP:0001025)2.32537403
72Abnormal platelet volume (HP:0011876)2.29471985
73Recurrent gram-negative bacterial infections (HP:0005420)2.27838616
74Recurrent skin infections (HP:0001581)2.27376016
75Episodic fever (HP:0001954)2.22569335
76Pulmonary embolism (HP:0002204)2.22127026
77Encephalitis (HP:0002383)2.20483069
78Emphysema (HP:0002097)2.19466435
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17709423
80Prolonged bleeding time (HP:0003010)2.17352562
81Ureteral obstruction (HP:0006000)2.15291058
82Gastrointestinal infarctions (HP:0005244)2.15136107
83Hypochromic anemia (HP:0001931)2.12702901
84Slow saccadic eye movements (HP:0000514)2.08062447
85Skin ulcer (HP:0200042)2.07902889
86Sepsis (HP:0100806)2.06925954
87Recurrent abscess formation (HP:0002722)2.04512812
88Osteomyelitis (HP:0002754)2.03814420
89Epistaxis (HP:0000421)2.02014821
90Mediastinal lymphadenopathy (HP:0100721)2.01095035
91Chest pain (HP:0100749)2.00287480
92Pulmonary infiltrates (HP:0002113)1.99322273
93Seborrheic dermatitis (HP:0001051)1.98286128
94Anorexia (HP:0002039)1.98005363
95Hematochezia (HP:0002573)1.97722753
96Gastrointestinal stroma tumor (HP:0100723)1.97163848
97Gangrene (HP:0100758)1.96694437
98Recurrent pneumonia (HP:0006532)1.95752545
99Restrictive lung disease (HP:0002091)1.95208298
100Villous atrophy (HP:0011473)1.94986236
101Abnormality of small intestinal villus morphology (HP:0011472)1.94986236
102Lip pit (HP:0100267)1.91545298
103Poikiloderma (HP:0001029)1.89417882
104Premature loss of primary teeth (HP:0006323)1.89318194
105Increased mean platelet volume (HP:0011877)1.87060964
106Abnormality of the pleura (HP:0002103)1.86011267
107Abnormality of the prostate (HP:0008775)1.85519222
108Keratitis (HP:0000491)1.84774930
109Gingival bleeding (HP:0000225)1.82644183
110Bicuspid aortic valve (HP:0001647)1.81362785
111Frequent falls (HP:0002359)1.78940253
112Chronic obstructive pulmonary disease (HP:0006510)1.78257599
113Obstructive lung disease (HP:0006536)1.78257599
114Optic neuritis (HP:0100653)1.78201542
115Retrobulbar optic neuritis (HP:0100654)1.78201542
116Ileus (HP:0002595)1.77754973
117Entropion (HP:0000621)1.76843305
118Hepatitis (HP:0012115)1.75766187
119Increased density of long bones (HP:0006392)1.75134279
120Cellulitis (HP:0100658)1.74067764
121Arterial thrombosis (HP:0004420)1.72950958
122Orchitis (HP:0100796)1.71201692
123Periodontitis (HP:0000704)1.71100148
124Aortic aneurysm (HP:0004942)1.69815580
125Aplasia/Hypoplasia of the thymus (HP:0010515)1.69048916
126Petechiae (HP:0000967)1.66996076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.46563466
2TXK4.79778027
3FGFR43.60353748
4ITK3.22649803
5JAK33.20427911
6STK103.13084106
7TYK22.93689852
8ZAP702.91559337
9GRK62.87217120
10IKBKE2.79594014
11RIPK42.75977468
12NLK2.34906822
13FGFR32.31498882
14PRPF4B2.27215520
15MAP3K102.21437178
16JAK11.94468869
17MAP3K141.89416820
18MAP3K131.88303809
19* LCK1.76055032
20MST41.73080037
21EEF2K1.64381193
22CSK1.63842097
23TBK11.58714533
24BTK1.43513937
25MARK31.41771318
26HCK1.40906900
27TEC1.40824065
28PKN21.40364045
29SYK1.35107436
30CDK121.33562998
31PRKCQ1.21971750
32LRRK21.21480883
33CAMKK21.18099979
34SIK21.15654475
35PRKCH1.14584353
36TYRO31.13099720
37TESK21.10771795
38TTN1.06439841
39NME21.05917924
40JAK21.05778504
41CAMKK11.05410672
42FGFR21.03347494
43BLK1.02868920
44MAP3K70.99737850
45KDR0.99638502
46IKBKB0.98090712
47TGFBR20.97434037
48NEK60.96061155
49PDGFRB0.93904474
50PIM10.93878184
51IRAK40.93618000
52CDC42BPA0.92958436
53MAP2K20.91346571
54KIT0.89753356
55MAP3K30.86918833
56FGR0.85990938
57EPHB10.85790124
58TRIB30.84703966
59PRKD20.80108521
60TNK20.78085746
61STK40.77492783
62RPS6KA40.73973186
63CHUK0.73659639
64CLK10.70206384
65PIK3CG0.67379262
66MARK20.67255272
67ERN10.67174665
68BMPR20.66429355
69MAP3K10.64652832
70TAOK10.61701282
71WNK10.59477889
72FLT30.58725172
73PDK10.56612054
74EPHA30.56404391
75LYN0.56236753
76RPS6KB20.55794668
77CDK40.54448907
78PTK2B0.53806790
79MAP2K30.52399763
80MAPK70.52061627
81CSF1R0.52020118
82SIK30.51708208
83MELK0.50792914
84PTK60.50313809
85BRD40.47858302
86FRK0.46769181
87MATK0.44632602
88FGFR10.43576690
89MAP3K110.43513562
90INSR0.42305677
91HIPK20.41768877
92TRPM70.41763638
93TESK10.38633978
94MAPK110.38065049
95TAOK30.37853881
96FES0.37381937
97SIK10.36968827
98MAPK120.36676587
99STK110.36443349
100RPS6KC10.36384775
101RPS6KL10.36384775
102PDPK10.36179631
103YES10.36026124
104FYN0.35671988
105RPS6KA60.35654454
106IRAK10.35123858
107ALK0.35070792
108NEK20.34889865
109KSR20.32892678
110MAPKAPK20.32736254
111EGFR0.30979890
112MAP2K60.30859716
113CDK60.30228047
114IGF1R0.27691198
115MAP3K80.27533255
116DYRK1B0.26248440
117MAPK30.25297139
118MAPK40.24075589
119PTK20.22995662
120PASK0.22611623
121STK380.21979162
122RET0.21659462
123PRKD10.20447433
124DMPK0.19944602
125RPS6KA50.19568562
126CDK90.18306261

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.15832634
2T cell receptor signaling pathway_Homo sapiens_hsa046604.11500788
3Measles_Homo sapiens_hsa051622.84976691
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.75274908
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.70433154
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68626283
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.67182337
8Antigen processing and presentation_Homo sapiens_hsa046122.39063533
9Hematopoietic cell lineage_Homo sapiens_hsa046402.20457818
10B cell receptor signaling pathway_Homo sapiens_hsa046622.04151772
11Osteoclast differentiation_Homo sapiens_hsa043801.99946720
12Graft-versus-host disease_Homo sapiens_hsa053321.94685752
13Allograft rejection_Homo sapiens_hsa053301.90942131
14Leishmaniasis_Homo sapiens_hsa051401.81834116
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.78170159
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75100535
17Herpes simplex infection_Homo sapiens_hsa051681.70760536
18Viral myocarditis_Homo sapiens_hsa054161.70395759
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.60204226
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58361814
21Acute myeloid leukemia_Homo sapiens_hsa052211.56816337
22Toxoplasmosis_Homo sapiens_hsa051451.47671896
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43340480
24Autoimmune thyroid disease_Homo sapiens_hsa053201.39446300
25Influenza A_Homo sapiens_hsa051641.35479408
26Chemokine signaling pathway_Homo sapiens_hsa040621.35448522
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35184711
28Hepatitis B_Homo sapiens_hsa051611.33225006
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32494798
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31788617
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27148105
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24359752
33HTLV-I infection_Homo sapiens_hsa051661.15170933
34Hepatitis C_Homo sapiens_hsa051601.12468144
35Pancreatic cancer_Homo sapiens_hsa052121.10195426
36TNF signaling pathway_Homo sapiens_hsa046681.07907607
37Shigellosis_Homo sapiens_hsa051311.06210180
38Platelet activation_Homo sapiens_hsa046111.05596134
39Chronic myeloid leukemia_Homo sapiens_hsa052201.04316936
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03037717
41Other glycan degradation_Homo sapiens_hsa005111.02313260
42Apoptosis_Homo sapiens_hsa042101.01223479
43VEGF signaling pathway_Homo sapiens_hsa043700.99543226
44Colorectal cancer_Homo sapiens_hsa052100.98982565
45Prolactin signaling pathway_Homo sapiens_hsa049170.92176095
46Epstein-Barr virus infection_Homo sapiens_hsa051690.91074348
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88333349
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87746599
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83186479
50Viral carcinogenesis_Homo sapiens_hsa052030.81600726
51Ribosome_Homo sapiens_hsa030100.78445558
52Rheumatoid arthritis_Homo sapiens_hsa053230.77589694
53Non-small cell lung cancer_Homo sapiens_hsa052230.75125673
54* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74339607
55Non-homologous end-joining_Homo sapiens_hsa034500.71358211
56Small cell lung cancer_Homo sapiens_hsa052220.70954676
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70774588
58p53 signaling pathway_Homo sapiens_hsa041150.70189084
59Endometrial cancer_Homo sapiens_hsa052130.68552159
60Thyroid cancer_Homo sapiens_hsa052160.65454514
61Inositol phosphate metabolism_Homo sapiens_hsa005620.64654614
62Salmonella infection_Homo sapiens_hsa051320.64271202
63FoxO signaling pathway_Homo sapiens_hsa040680.62989162
64Tuberculosis_Homo sapiens_hsa051520.62899647
65Notch signaling pathway_Homo sapiens_hsa043300.62863034
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59496184
67Legionellosis_Homo sapiens_hsa051340.59190314
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58329958
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.58187592
70* Phospholipase D signaling pathway_Homo sapiens_hsa040720.58164881
71Adherens junction_Homo sapiens_hsa045200.56055026
72Malaria_Homo sapiens_hsa051440.56011395
73mTOR signaling pathway_Homo sapiens_hsa041500.55366165
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55338775
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54832830
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54713682
77Insulin resistance_Homo sapiens_hsa049310.54439927
78GnRH signaling pathway_Homo sapiens_hsa049120.53481036
79Spliceosome_Homo sapiens_hsa030400.52337644
80Prostate cancer_Homo sapiens_hsa052150.52168356
81Type I diabetes mellitus_Homo sapiens_hsa049400.51777539
82Endocytosis_Homo sapiens_hsa041440.50530440
83Pertussis_Homo sapiens_hsa051330.49546919
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47598255
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46760693
86Regulation of autophagy_Homo sapiens_hsa041400.45875843
87Asthma_Homo sapiens_hsa053100.45232301
88Ras signaling pathway_Homo sapiens_hsa040140.44100033
89Lysine degradation_Homo sapiens_hsa003100.43463391
90Rap1 signaling pathway_Homo sapiens_hsa040150.43079087
91Phagosome_Homo sapiens_hsa041450.42469495
92Staphylococcus aureus infection_Homo sapiens_hsa051500.42231657
93mRNA surveillance pathway_Homo sapiens_hsa030150.41604391
94ErbB signaling pathway_Homo sapiens_hsa040120.41278318
95Renal cell carcinoma_Homo sapiens_hsa052110.40717631
96* Glycerophospholipid metabolism_Homo sapiens_hsa005640.40656727
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40324419
98MAPK signaling pathway_Homo sapiens_hsa040100.39154741
99Renin secretion_Homo sapiens_hsa049240.37759189
100Pathways in cancer_Homo sapiens_hsa052000.37537982
101Proteoglycans in cancer_Homo sapiens_hsa052050.37210253
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35949751
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.35771104
104Long-term potentiation_Homo sapiens_hsa047200.34420668
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.33184009
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32463543
107Arachidonic acid metabolism_Homo sapiens_hsa005900.32244261
108HIF-1 signaling pathway_Homo sapiens_hsa040660.31809264
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31241332
110Type II diabetes mellitus_Homo sapiens_hsa049300.30311560
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.30309236
112Glioma_Homo sapiens_hsa052140.29715418
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.29008936
114ABC transporters_Homo sapiens_hsa020100.26881591
115* Choline metabolism in cancer_Homo sapiens_hsa052310.26342100
116Dorso-ventral axis formation_Homo sapiens_hsa043200.25756406
117MicroRNAs in cancer_Homo sapiens_hsa052060.22852415
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21595938
119RNA degradation_Homo sapiens_hsa030180.21268134
120African trypanosomiasis_Homo sapiens_hsa051430.20894823

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »