DGKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78470165
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55110892
3locomotory exploration behavior (GO:0035641)5.52988922
4vocalization behavior (GO:0071625)5.29019791
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17125790
6synaptic vesicle maturation (GO:0016188)5.04053019
7regulation of glutamate receptor signaling pathway (GO:1900449)4.98194502
8synaptic vesicle exocytosis (GO:0016079)4.82880322
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.79976456
10regulation of synapse structural plasticity (GO:0051823)4.77986122
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77578046
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.75710387
13neurotransmitter-gated ion channel clustering (GO:0072578)4.74731485
14regulation of neuronal synaptic plasticity (GO:0048168)4.54247243
15protein localization to synapse (GO:0035418)4.53442241
16synaptic transmission, dopaminergic (GO:0001963)4.43478004
17regulation of synaptic vesicle exocytosis (GO:2000300)4.41313025
18prepulse inhibition (GO:0060134)4.37472586
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37339552
20neuron-neuron synaptic transmission (GO:0007270)4.37090729
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.36986997
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.34580884
23glutamate receptor signaling pathway (GO:0007215)4.33105385
24striatum development (GO:0021756)4.27584727
25neuronal action potential propagation (GO:0019227)4.26906653
26positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.26819603
27exploration behavior (GO:0035640)4.25048506
28synaptic transmission, glutamatergic (GO:0035249)4.21575657
29glutamate secretion (GO:0014047)4.20372898
30neuron cell-cell adhesion (GO:0007158)4.20172899
31neurotransmitter secretion (GO:0007269)4.10828667
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08852727
33long-term memory (GO:0007616)4.06813204
34regulation of dendritic spine morphogenesis (GO:0061001)4.04108669
35presynaptic membrane organization (GO:0097090)4.00829964
36regulation of synaptic vesicle transport (GO:1902803)3.99419802
37auditory behavior (GO:0031223)3.98716002
38behavioral response to cocaine (GO:0048148)3.94765120
39long-term synaptic potentiation (GO:0060291)3.92360704
40regulation of synaptic transmission, glutamatergic (GO:0051966)3.86295016
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.85817820
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.85509394
43positive regulation of membrane potential (GO:0045838)3.85479935
44transmission of nerve impulse (GO:0019226)3.84385146
45regulation of synaptic plasticity (GO:0048167)3.82746327
46regulation of female receptivity (GO:0045924)3.82428620
47response to histamine (GO:0034776)3.80837954
48regulation of postsynaptic membrane potential (GO:0060078)3.80771739
49C4-dicarboxylate transport (GO:0015740)3.79529386
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.75388005
51dendritic spine morphogenesis (GO:0060997)3.73142385
52regulation of glutamate secretion (GO:0014048)3.72925666
53gamma-aminobutyric acid transport (GO:0015812)3.71510741
54response to auditory stimulus (GO:0010996)3.70757155
55startle response (GO:0001964)3.69994101
56response to amphetamine (GO:0001975)3.68464440
57behavioral fear response (GO:0001662)3.68281130
58behavioral defense response (GO:0002209)3.68281130
59positive regulation of neurotransmitter transport (GO:0051590)3.67673128
60membrane depolarization during action potential (GO:0086010)3.63891061
61behavioral response to nicotine (GO:0035095)3.58188938
62positive regulation of neurotransmitter secretion (GO:0001956)3.56984921
63neuromuscular process controlling balance (GO:0050885)3.56723174
64layer formation in cerebral cortex (GO:0021819)3.55953992
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55124813
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53986808
67female mating behavior (GO:0060180)3.50959910
68serotonin metabolic process (GO:0042428)3.42273135
69regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.41057397
70regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.41057397
71fear response (GO:0042596)3.40588458
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40258550
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.39146993
74cellular potassium ion homeostasis (GO:0030007)3.38232231
75regulation of neurotransmitter uptake (GO:0051580)3.35567870
76dopamine receptor signaling pathway (GO:0007212)3.35062054
77neurotransmitter transport (GO:0006836)3.31624276
78regulation of dendritic spine development (GO:0060998)3.31202016
79positive regulation of synapse maturation (GO:0090129)3.29901574
80learning (GO:0007612)3.27343972
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26280518
82positive regulation of synaptic transmission (GO:0050806)3.24348338
83activation of protein kinase A activity (GO:0034199)3.22859706
84neuromuscular synaptic transmission (GO:0007274)3.22336640
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21514885
86regulation of protein kinase A signaling (GO:0010738)3.20984273
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20820483
88neuronal ion channel clustering (GO:0045161)3.20666338
89regulation of neurotransmitter levels (GO:0001505)3.19746414
90mechanosensory behavior (GO:0007638)3.19317529
91primary amino compound metabolic process (GO:1901160)3.19174847
92membrane depolarization (GO:0051899)3.18820683
93visual learning (GO:0008542)3.17468700
94regulation of voltage-gated calcium channel activity (GO:1901385)3.16332309
95regulation of neurotransmitter transport (GO:0051588)3.15933933
96long term synaptic depression (GO:0060292)3.14998083
97regulation of neurotransmitter secretion (GO:0046928)3.14634606
98pyrimidine nucleobase catabolic process (GO:0006208)3.13944837
99presynaptic membrane assembly (GO:0097105)3.13671775
100membrane hyperpolarization (GO:0060081)3.13146924
101neuron recognition (GO:0008038)3.12370356
102negative regulation of dendrite development (GO:2000171)3.12160613
103proline transport (GO:0015824)3.11855023
104negative regulation of amino acid transport (GO:0051956)3.11761371
105postsynaptic membrane organization (GO:0001941)3.11250451
106regulation of vesicle fusion (GO:0031338)3.11184458
107retinal cone cell development (GO:0046549)3.09993907
108central nervous system myelination (GO:0022010)3.09176968
109axon ensheathment in central nervous system (GO:0032291)3.09176968
110positive regulation of dendritic spine development (GO:0060999)3.08931767
111neuronal action potential (GO:0019228)3.08632290
112visual behavior (GO:0007632)3.06981761
113cAMP catabolic process (GO:0006198)3.06809366
114L-amino acid import (GO:0043092)3.05603649
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04013163
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03312580
117adult walking behavior (GO:0007628)3.02068062
118nucleobase catabolic process (GO:0046113)2.98791317
119synaptic vesicle endocytosis (GO:0048488)2.92838498
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91006959
121behavioral response to ethanol (GO:0048149)2.89769183
122glycosphingolipid biosynthetic process (GO:0006688)2.88265080
123detection of light stimulus involved in sensory perception (GO:0050962)2.87094750
124detection of light stimulus involved in visual perception (GO:0050908)2.87094750
125cochlea development (GO:0090102)2.86296627
126synaptic transmission (GO:0007268)2.85056262
127cerebellar Purkinje cell differentiation (GO:0021702)2.80907469
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.77056314
129adult behavior (GO:0030534)2.73967092
130detection of calcium ion (GO:0005513)2.70501755
131axonal fasciculation (GO:0007413)2.69326151
132synapse assembly (GO:0007416)2.68717263
133cellular potassium ion transport (GO:0071804)2.66925445
134potassium ion transmembrane transport (GO:0071805)2.66925445
135action potential (GO:0001508)2.63756659
136auditory receptor cell stereocilium organization (GO:0060088)2.62384970
137phosphorelay signal transduction system (GO:0000160)2.62123165
138neurotransmitter uptake (GO:0001504)2.60807860
139neuromuscular process controlling posture (GO:0050884)2.60024885
140righting reflex (GO:0060013)2.55705924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75501397
2* GBX2_23144817_ChIP-Seq_PC3_Human3.59069698
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26732405
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23605309
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11467733
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.10284177
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77004689
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74905957
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74905957
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69662828
11REST_21632747_ChIP-Seq_MESCs_Mouse2.67385204
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61795146
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57574053
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53919891
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51995114
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50008664
17DROSHA_22980978_ChIP-Seq_HELA_Human2.47833906
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.29942877
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22463815
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.20248084
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19049350
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17154756
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.16402811
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.16009229
25VDR_22108803_ChIP-Seq_LS180_Human2.12374384
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03930330
27AR_21572438_ChIP-Seq_LNCaP_Human2.02855208
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83378045
29TAF15_26573619_Chip-Seq_HEK293_Human1.82142598
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80714807
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72559339
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71063565
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70587269
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.70300193
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68632694
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67659340
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65125731
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64232081
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.60966465
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.49204105
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47552509
42P300_19829295_ChIP-Seq_ESCs_Human1.47488844
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45323237
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45323237
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43864007
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43539590
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41966582
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39384017
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.37396902
50* EWS_26573619_Chip-Seq_HEK293_Human1.36156890
51ER_23166858_ChIP-Seq_MCF-7_Human1.35899937
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34008339
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.32092908
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31892947
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30518763
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29187411
57CBP_20019798_ChIP-Seq_JUKART_Human1.29187411
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28874483
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26610933
60* AR_25329375_ChIP-Seq_VCAP_Human1.25841531
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.25418944
62* STAT3_23295773_ChIP-Seq_U87_Human1.25300943
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24668667
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23053221
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23003596
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22356755
67TCF4_22108803_ChIP-Seq_LS180_Human1.21106525
68* FLI1_21867929_ChIP-Seq_TH2_Mouse1.21042737
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20301510
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.20156784
71* AR_19668381_ChIP-Seq_PC3_Human1.20112606
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19688886
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.19289128
74ZNF274_21170338_ChIP-Seq_K562_Hela1.19039697
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18667899
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18565497
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18054747
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17029532
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.16503404
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15646088
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15448421
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15409040
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14887216
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12375701
85* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11788345
86SOX2_19829295_ChIP-Seq_ESCs_Human1.10988778
87NANOG_19829295_ChIP-Seq_ESCs_Human1.10988778
88* TCF4_23295773_ChIP-Seq_U87_Human1.09574172
89TP53_16413492_ChIP-PET_HCT116_Human1.08769452
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08365875
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.08339099
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07781525
93KDM2B_26808549_Chip-Seq_REH_Human1.06708093
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06654680
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06430592
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06011518
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04616190
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.04537862
99RXR_22108803_ChIP-Seq_LS180_Human1.03775027
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03692401
101RUNX2_22187159_ChIP-Seq_PCA_Human1.03617257
102P53_22387025_ChIP-Seq_ESCs_Mouse1.03368154
103AHR_22903824_ChIP-Seq_MCF-7_Human1.03258569
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02928580
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02605172
106* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02580453
107* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02502590
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02104746
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.01703194
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.00869899
111TP53_22573176_ChIP-Seq_HFKS_Human1.00690591
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00591011
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00457642
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00435750
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00422308
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00066029
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99646055
118FUS_26573619_Chip-Seq_HEK293_Human0.99133310
119BCAT_22108803_ChIP-Seq_LS180_Human0.97797618
120RNF2_27304074_Chip-Seq_NSC_Mouse0.96746563
121JUN_21703547_ChIP-Seq_K562_Human0.93772989
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92648739
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.91403748
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.90538094
125TP53_18474530_ChIP-ChIP_U2OS_Human0.90168915
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89053257
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88332131
128IGF1R_20145208_ChIP-Seq_DFB_Human0.87563024
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87520614
130KDM2B_26808549_Chip-Seq_K562_Human0.87070916
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84704975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.57515354
2MP0002822_catalepsy6.09622609
3MP0003880_abnormal_central_pattern4.97730457
4* MP0003635_abnormal_synaptic_transmissio4.20084344
5MP0009745_abnormal_behavioral_response3.75775754
6MP0004270_analgesia3.50075321
7* MP0002063_abnormal_learning/memory/cond3.48513493
8MP0002064_seizures3.18638814
9MP0009046_muscle_twitch2.95333314
10MP0002572_abnormal_emotion/affect_behav2.92789187
11MP0001968_abnormal_touch/_nociception2.82242092
12MP0001486_abnormal_startle_reflex2.74100954
13MP0002272_abnormal_nervous_system2.60325423
14MP0005646_abnormal_pituitary_gland2.33454112
15MP0001501_abnormal_sleep_pattern2.32603492
16MP0001529_abnormal_vocalization2.32350589
17MP0005423_abnormal_somatic_nervous2.25043123
18MP0002734_abnormal_mechanical_nocicepti2.24570761
19MP0002736_abnormal_nociception_after2.15026514
20MP0001440_abnormal_grooming_behavior2.08294710
21MP0008877_abnormal_DNA_methylation2.07458630
22MP0009780_abnormal_chondrocyte_physiolo1.94800697
23MP0002909_abnormal_adrenal_gland1.93720369
24MP0005386_behavior/neurological_phenoty1.85195146
25MP0004924_abnormal_behavior1.85195146
26MP0001970_abnormal_pain_threshold1.81271168
27MP0002067_abnormal_sensory_capabilities1.79937524
28MP0002733_abnormal_thermal_nociception1.79790420
29MP0002735_abnormal_chemical_nociception1.77010654
30MP0008569_lethality_at_weaning1.74087595
31MP0003329_amyloid_beta_deposits1.70244301
32MP0002557_abnormal_social/conspecific_i1.69456716
33MP0001984_abnormal_olfaction1.67324905
34MP0004811_abnormal_neuron_physiology1.59099608
35MP0003879_abnormal_hair_cell1.51892810
36MP0004858_abnormal_nervous_system1.48187174
37MP0002102_abnormal_ear_morphology1.47607329
38MP0001188_hyperpigmentation1.47347188
39MP0002184_abnormal_innervation1.47288725
40MP0003646_muscle_fatigue1.46388905
41MP0000778_abnormal_nervous_system1.42673643
42MP0001905_abnormal_dopamine_level1.40208098
43MP0003633_abnormal_nervous_system1.39670651
44MP0001986_abnormal_taste_sensitivity1.37021127
45MP0004885_abnormal_endolymph1.34043970
46MP0002066_abnormal_motor_capabilities/c1.33900941
47MP0000955_abnormal_spinal_cord1.33754986
48MP0005253_abnormal_eye_physiology1.33053387
49MP0005409_darkened_coat_color1.32072981
50MP0004147_increased_porphyrin_level1.31761005
51MP0005645_abnormal_hypothalamus_physiol1.25197924
52* MP0002882_abnormal_neuron_morphology1.22983047
53MP0001502_abnormal_circadian_rhythm1.18532020
54MP0003121_genomic_imprinting1.18190201
55MP0003195_calcinosis1.17593436
56MP0003787_abnormal_imprinting1.17494389
57MP0006276_abnormal_autonomic_nervous1.17107461
58MP0008872_abnormal_physiological_respon1.15787426
59MP0003631_nervous_system_phenotype1.13143928
60MP0003075_altered_response_to1.12090996
61MP0008874_decreased_physiological_sensi1.11301255
62MP0006072_abnormal_retinal_apoptosis1.09998298
63MP0000013_abnormal_adipose_tissue1.09591352
64MP0003690_abnormal_glial_cell1.04259994
65MP0001177_atelectasis1.03495697
66MP0004142_abnormal_muscle_tone1.02961591
67* MP0002152_abnormal_brain_morphology0.97140566
68MP0005167_abnormal_blood-brain_barrier0.96374517
69MP0004133_heterotaxia0.95711763
70MP0002069_abnormal_eating/drinking_beha0.94710448
71MP0004085_abnormal_heartbeat0.93769051
72MP0002751_abnormal_autonomic_nervous0.88616196
73MP0005535_abnormal_body_temperature0.86343471
74MP0000751_myopathy0.84453081
75MP0000579_abnormal_nail_morphology0.82191587
76MP0002229_neurodegeneration0.82120189
77MP0000026_abnormal_inner_ear0.81356306
78MP0005551_abnormal_eye_electrophysiolog0.78755571
79MP0003122_maternal_imprinting0.77867984
80MP0010386_abnormal_urinary_bladder0.76921604
81MP0002090_abnormal_vision0.76774530
82MP0008961_abnormal_basal_metabolism0.76717285
83MP0000604_amyloidosis0.76447910
84MP0003634_abnormal_glial_cell0.74963568
85MP0000631_abnormal_neuroendocrine_gland0.73681893
86MP0005394_taste/olfaction_phenotype0.72311706
87MP0005499_abnormal_olfactory_system0.72311706
88MP0001485_abnormal_pinna_reflex0.72011806
89MP0002837_dystrophic_cardiac_calcinosis0.71719674
90MP0001963_abnormal_hearing_physiology0.71526121
91MP0004215_abnormal_myocardial_fiber0.70466177
92MP0000920_abnormal_myelination0.70247345
93MP0006292_abnormal_olfactory_placode0.70046403
94MP0003632_abnormal_nervous_system0.69864465
95MP0002234_abnormal_pharynx_morphology0.69392860
96MP0010234_abnormal_vibrissa_follicle0.67649458
97MP0003136_yellow_coat_color0.67424424
98MP0001664_abnormal_digestion0.66648964
99MP0004145_abnormal_muscle_electrophysio0.66084894
100MP0002876_abnormal_thyroid_physiology0.65566541
101MP0004742_abnormal_vestibular_system0.64818777
102MP0003137_abnormal_impulse_conducting0.64528694
103MP0003119_abnormal_digestive_system0.64014661
104MP0008789_abnormal_olfactory_epithelium0.63759746
105MP0003045_fibrosis0.63563573
106MP0005195_abnormal_posterior_eye0.63405971
107MP0003938_abnormal_ear_development0.63211433
108MP0004484_altered_response_of0.63193217
109MP0008875_abnormal_xenobiotic_pharmacok0.62560106
110MP0003890_abnormal_embryonic-extraembry0.62220596
111MP0003698_abnormal_male_reproductive0.61841730
112MP0000569_abnormal_digit_pigmentation0.61102724
113MP0002752_abnormal_somatic_nervous0.58673548
114MP0002638_abnormal_pupillary_reflex0.58626227
115MP0002928_abnormal_bile_duct0.58340694
116MP0000427_abnormal_hair_cycle0.58312055
117MP0004043_abnormal_pH_regulation0.58198411
118MP0003283_abnormal_digestive_organ0.57238600
119MP0004233_abnormal_muscle_weight0.53301065
120MP0001943_abnormal_respiration0.51961089
121MP0005171_absent_coat_pigmentation0.47086671
122MP0005166_decreased_susceptibility_to0.44821051
123MP0003956_abnormal_body_size0.44778601
124MP0005620_abnormal_muscle_contractility0.43914441
125MP0001765_abnormal_ion_homeostasis0.43514612
126MP0005595_abnormal_vascular_smooth0.43407053

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.89632915
2Myokymia (HP:0002411)8.09922514
3Focal seizures (HP:0007359)6.20276447
4Epileptic encephalopathy (HP:0200134)4.75913726
5Visual hallucinations (HP:0002367)4.73174305
6Atonic seizures (HP:0010819)4.36928156
7Febrile seizures (HP:0002373)4.31180328
8Absence seizures (HP:0002121)4.19829263
9Generalized tonic-clonic seizures (HP:0002069)3.97018780
10Action tremor (HP:0002345)3.96590904
11Dialeptic seizures (HP:0011146)3.95851298
12Hyperventilation (HP:0002883)3.92775079
13Progressive cerebellar ataxia (HP:0002073)3.84227924
14Broad-based gait (HP:0002136)3.81797207
15Poor eye contact (HP:0000817)3.75738190
16Anxiety (HP:0000739)3.61989793
17Dysdiadochokinesis (HP:0002075)3.59732896
18Impaired vibration sensation in the lower limbs (HP:0002166)3.59471945
19Gaze-evoked nystagmus (HP:0000640)3.48731122
20Depression (HP:0000716)3.45136847
21Impaired social interactions (HP:0000735)3.40569414
22Abnormal social behavior (HP:0012433)3.40569414
23Type II lissencephaly (HP:0007260)3.33090393
24Torticollis (HP:0000473)3.27954810
25Dysmetria (HP:0001310)3.27554670
26Annular pancreas (HP:0001734)3.21933580
27Truncal ataxia (HP:0002078)3.21704969
28Ankle clonus (HP:0011448)3.14452921
29Postural instability (HP:0002172)3.07639189
30Urinary bladder sphincter dysfunction (HP:0002839)3.06169292
31Pancreatic fibrosis (HP:0100732)3.05295427
32Amblyopia (HP:0000646)3.04368119
33Resting tremor (HP:0002322)3.03530807
34Focal dystonia (HP:0004373)3.02360037
35True hermaphroditism (HP:0010459)3.01355910
36Scanning speech (HP:0002168)3.01091898
37Pancreatic cysts (HP:0001737)3.00791917
38Abnormal eating behavior (HP:0100738)2.97801743
39Supranuclear gaze palsy (HP:0000605)2.96333193
40Stereotypic behavior (HP:0000733)2.90684161
41Medial flaring of the eyebrow (HP:0010747)2.89400704
42Craniofacial dystonia (HP:0012179)2.78147883
43Gait imbalance (HP:0002141)2.74722104
44Dysmetric saccades (HP:0000641)2.73283674
45Impaired smooth pursuit (HP:0007772)2.70549343
46Hemiparesis (HP:0001269)2.66840377
47Urinary urgency (HP:0000012)2.66117809
48Bradykinesia (HP:0002067)2.64339768
49Cerebral inclusion bodies (HP:0100314)2.62181345
50Papilledema (HP:0001085)2.61532421
51Megalencephaly (HP:0001355)2.60950907
52Molar tooth sign on MRI (HP:0002419)2.57484865
53Abnormality of midbrain morphology (HP:0002418)2.57484865
54Progressive inability to walk (HP:0002505)2.56252713
55Neurofibrillary tangles (HP:0002185)2.55213870
56Thyroid-stimulating hormone excess (HP:0002925)2.54661111
57Nephronophthisis (HP:0000090)2.54653385
58Abnormality of the labia minora (HP:0012880)2.52402159
59Drooling (HP:0002307)2.50590993
60Excessive salivation (HP:0003781)2.50590993
61Impaired vibratory sensation (HP:0002495)2.50423840
62Epileptiform EEG discharges (HP:0011182)2.50027757
63Abnormality of binocular vision (HP:0011514)2.49206144
64Diplopia (HP:0000651)2.49206144
65Ankyloglossia (HP:0010296)2.45922883
66Spastic gait (HP:0002064)2.42640115
67Intention tremor (HP:0002080)2.41115110
68Cerebellar dysplasia (HP:0007033)2.40727700
69Congenital primary aphakia (HP:0007707)2.38693166
70Genital tract atresia (HP:0001827)2.38103068
71Aplasia involving bones of the upper limbs (HP:0009823)2.37850070
72Aplasia of the phalanges of the hand (HP:0009802)2.37850070
73Aplasia involving bones of the extremities (HP:0009825)2.37850070
74Polydipsia (HP:0001959)2.36809386
75Abnormal drinking behavior (HP:0030082)2.36809386
76EEG with generalized epileptiform discharges (HP:0011198)2.33912089
77Abolished electroretinogram (ERG) (HP:0000550)2.32018238
78Genetic anticipation (HP:0003743)2.31441152
79Congenital stationary night blindness (HP:0007642)2.31332429
80Optic nerve hypoplasia (HP:0000609)2.30952934
81Abnormality of ocular smooth pursuit (HP:0000617)2.29612151
82Vaginal atresia (HP:0000148)2.29529987
83Status epilepticus (HP:0002133)2.27913750
84Hemiplegia (HP:0002301)2.27079055
85Mutism (HP:0002300)2.26614617
86Lissencephaly (HP:0001339)2.24890700
87Insidious onset (HP:0003587)2.23043551
88Termporal pattern (HP:0011008)2.23043551
89Incomplete penetrance (HP:0003829)2.22907403
90Pointed chin (HP:0000307)2.21898478
91Hypsarrhythmia (HP:0002521)2.20739212
92Abnormality of the lower motor neuron (HP:0002366)2.20259485
93Abnormality of the renal medulla (HP:0100957)2.19851776
94Nephrogenic diabetes insipidus (HP:0009806)2.19257292
95Retinal dysplasia (HP:0007973)2.18233566
96Inability to walk (HP:0002540)2.14772958
97Absent speech (HP:0001344)2.13540485
98Lower limb amyotrophy (HP:0007210)2.11077309
99Lower limb muscle weakness (HP:0007340)2.10456259
100Intestinal atresia (HP:0011100)2.09902743
101Agitation (HP:0000713)2.09742725
102Abnormal EKG (HP:0003115)2.07919174
103Prolonged QT interval (HP:0001657)2.07813054
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07101308
105Generalized myoclonic seizures (HP:0002123)2.02868234
106Abnormality of the renal cortex (HP:0011035)2.02548720
107Fetal akinesia sequence (HP:0001989)2.02471858
108Cystic liver disease (HP:0006706)2.00543918
109Blue irides (HP:0000635)1.98868667
110Attenuation of retinal blood vessels (HP:0007843)1.98598808
111Gait ataxia (HP:0002066)1.98507390
112Decreased central vision (HP:0007663)1.97646650
113Limb dystonia (HP:0002451)1.96774449
114Chronic hepatic failure (HP:0100626)1.96610019
115Pheochromocytoma (HP:0002666)1.90422816
116Abnormality of macular pigmentation (HP:0008002)1.85975128
117Oligodactyly (hands) (HP:0001180)1.82919305
118Rigidity (HP:0002063)1.82715579
119Spinal canal stenosis (HP:0003416)1.82455899
120Ventricular fibrillation (HP:0001663)1.82290716
121Abnormality of oral frenula (HP:0000190)1.82073230
122Psychosis (HP:0000709)1.81619280
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81579113
124Lower limb asymmetry (HP:0100559)1.81573755
125Neuronal loss in central nervous system (HP:0002529)1.80772935
126Deeply set eye (HP:0000490)1.80361888
127Delusions (HP:0000746)1.79302996
128Pachygyria (HP:0001302)1.78454761
129Protruding tongue (HP:0010808)1.78240385
130Abnormality of saccadic eye movements (HP:0000570)1.77832411
131Polyphagia (HP:0002591)1.76672990
132Specific learning disability (HP:0001328)1.76288577
133Clonus (HP:0002169)1.75151484
134Clumsiness (HP:0002312)1.74074563
135Thickened helices (HP:0000391)1.73282201
136Polyuria (HP:0000103)1.73144139
137Poor coordination (HP:0002370)1.72652507
138Abnormality of salivation (HP:0100755)1.72438417
139Tubular atrophy (HP:0000092)1.72406239
140Pendular nystagmus (HP:0012043)1.71384671
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.70905653
142Obstructive sleep apnea (HP:0002870)1.70372716
143Spastic tetraplegia (HP:0002510)1.69685023
144Split foot (HP:0001839)1.68236535
145Widely spaced teeth (HP:0000687)1.67106284
146Dyskinesia (HP:0100660)1.64718572
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.64290264
148Syncope (HP:0001279)1.63069802
149Cerebral hypomyelination (HP:0006808)1.62608648
150Sclerocornea (HP:0000647)1.60910317
151Severe muscular hypotonia (HP:0006829)1.60855641
152Postaxial hand polydactyly (HP:0001162)1.59830821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.56812889
2NTRK34.75347139
3FRK3.99153368
4MAP3K93.29245953
5BMPR1B2.89628588
6RIPK42.83894783
7MAP3K42.51127320
8MINK12.44223772
9DAPK22.41277053
10KSR22.37331380
11MAP4K22.21947961
12ADRBK22.13586943
13MAP2K72.10069885
14PRKD32.05706164
15NTRK22.05372748
16WNK32.00554908
17CAMKK11.92135239
18TNIK1.89861009
19CASK1.88787460
20NTRK11.88413522
21KSR11.85519613
22ARAF1.77210686
23MAP3K121.75969004
24MARK11.71448483
25DAPK11.70991790
26MAP3K131.69478110
27PAK61.67337123
28FES1.65193469
29INSRR1.64287299
30CDK51.54700157
31MAP2K41.54397415
32STK38L1.52441658
33PRPF4B1.45068460
34GRK11.36684708
35CAMKK21.33972182
36SIK21.28172364
37PLK21.27081480
38NUAK11.24807318
39MAP3K21.24579718
40BMPR21.23897798
41ACVR1B1.20042134
42RAF11.16954365
43PRKCG1.16494238
44PTK2B1.13138816
45GRK51.12370671
46STK381.11242111
47SGK4941.09635541
48SGK2231.09635541
49TAOK11.09525450
50SGK21.06826374
51WNK41.06652401
52CAMK2A1.05723959
53STK391.04392766
54CSNK1A1L1.02476153
55CSNK1G31.02388188
56CSNK1G10.99175767
57TYRO30.98536279
58CAMK2B0.94091830
59PNCK0.93831016
60MAPK130.90739555
61SIK30.90718905
62FGFR20.88605937
63DYRK20.86846029
64SGK30.86416721
65TRIM280.85722382
66CAMK10.85473276
67MKNK20.85071930
68SGK10.83840210
69TAOK30.83417200
70PKN10.82497841
71PINK10.81064114
72CDK180.80793566
73CDK190.78262914
74PRKCH0.75844169
75CDK150.75133645
76CDK140.74763672
77STK110.72447354
78UHMK10.70347689
79ADRBK10.69668545
80LMTK20.69069681
81FGR0.67519630
82TNK20.67441388
83PDPK10.67321790
84MAP3K10.66348257
85PDK10.66120701
86RET0.64565503
87CDK11A0.63575167
88MAP2K10.60613999
89MARK20.59650358
90PHKG20.59524958
91PHKG10.59524958
92NEK60.59057596
93CSNK1D0.58044748
94IRAK10.57795916
95AKT30.57424872
96MUSK0.57230401
97PRKCE0.55438423
98NME10.55185791
99BRAF0.52417631
100RPS6KA30.51699015
101DYRK1A0.51364553
102CSNK1A10.51173387
103OXSR10.50559717
104PRKCI0.50009268
105CAMK2D0.49828647
106TIE10.48408959
107ZAK0.47253402
108PRKCA0.46993761
109FYN0.46812074
110CAMK2G0.46804328
111PAK30.45217840
112BCR0.44499433
113PRKG10.44489604
114MAPK100.43372005
115PRKCZ0.43284193
116NEK10.41508837
117DMPK0.41211588
118MAPKAPK50.40890061
119FER0.40794374
120CAMK40.39587766
121PRKAA10.38300325
122ERBB30.38181901
123DAPK30.37564950
124PIK3CA0.37249082
125CSNK1E0.36793765
126PRKCB0.36548472
127MOS0.35440577
128ERBB20.35218449
129LATS20.34827113
130ALK0.33917665
131CSNK1G20.33517481
132PRKACA0.33387334
133MAP3K70.31199372
134PRKD20.31196226
135CDC42BPA0.31166607
136WNK10.31126989

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70139870
2Olfactory transduction_Homo sapiens_hsa047403.16387566
3Long-term potentiation_Homo sapiens_hsa047202.90801274
4Synaptic vesicle cycle_Homo sapiens_hsa047212.85177836
5Circadian entrainment_Homo sapiens_hsa047132.83338491
6Amphetamine addiction_Homo sapiens_hsa050312.81779338
7Morphine addiction_Homo sapiens_hsa050322.78347617
8GABAergic synapse_Homo sapiens_hsa047272.78014812
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69948538
10Glutamatergic synapse_Homo sapiens_hsa047242.64788721
11Dopaminergic synapse_Homo sapiens_hsa047282.33507402
12Salivary secretion_Homo sapiens_hsa049702.29981644
13Cocaine addiction_Homo sapiens_hsa050302.09779882
14Renin secretion_Homo sapiens_hsa049242.03285787
15Cholinergic synapse_Homo sapiens_hsa047252.01562440
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01397779
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93748837
18Gastric acid secretion_Homo sapiens_hsa049711.91765926
19Insulin secretion_Homo sapiens_hsa049111.90082070
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86518694
21Butanoate metabolism_Homo sapiens_hsa006501.85168830
22Calcium signaling pathway_Homo sapiens_hsa040201.82431281
23Oxytocin signaling pathway_Homo sapiens_hsa049211.74603732
24Long-term depression_Homo sapiens_hsa047301.74145691
25Serotonergic synapse_Homo sapiens_hsa047261.71419815
26Taste transduction_Homo sapiens_hsa047421.68751775
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63386193
28Gap junction_Homo sapiens_hsa045401.47665871
29GnRH signaling pathway_Homo sapiens_hsa049121.44948379
30Nitrogen metabolism_Homo sapiens_hsa009101.39498591
31cAMP signaling pathway_Homo sapiens_hsa040241.38320816
32Collecting duct acid secretion_Homo sapiens_hsa049661.37164539
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29928555
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28209680
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18084015
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17747968
37Glioma_Homo sapiens_hsa052141.13506739
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09383375
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06617820
40* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06144415
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.05476958
42Linoleic acid metabolism_Homo sapiens_hsa005911.05101771
43Estrogen signaling pathway_Homo sapiens_hsa049151.04846197
44Melanogenesis_Homo sapiens_hsa049161.03325505
45Regulation of autophagy_Homo sapiens_hsa041401.03306973
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99980300
47Ether lipid metabolism_Homo sapiens_hsa005650.98637717
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96283754
49Type II diabetes mellitus_Homo sapiens_hsa049300.94764310
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94360767
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.94004725
52Phototransduction_Homo sapiens_hsa047440.91804571
53Oxidative phosphorylation_Homo sapiens_hsa001900.91459989
54Cardiac muscle contraction_Homo sapiens_hsa042600.90484524
55ErbB signaling pathway_Homo sapiens_hsa040120.89319688
56Pancreatic secretion_Homo sapiens_hsa049720.88902159
57Propanoate metabolism_Homo sapiens_hsa006400.88596857
58Axon guidance_Homo sapiens_hsa043600.88096712
59Oocyte meiosis_Homo sapiens_hsa041140.87136724
60Dorso-ventral axis formation_Homo sapiens_hsa043200.85792108
61Protein export_Homo sapiens_hsa030600.85613267
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84781356
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84428025
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81672359
65* Phospholipase D signaling pathway_Homo sapiens_hsa040720.78687619
66Vibrio cholerae infection_Homo sapiens_hsa051100.78059897
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77761913
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77749858
69beta-Alanine metabolism_Homo sapiens_hsa004100.76273416
70Thyroid hormone synthesis_Homo sapiens_hsa049180.74196603
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73387695
72Dilated cardiomyopathy_Homo sapiens_hsa054140.71811871
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70621047
74Tryptophan metabolism_Homo sapiens_hsa003800.69303979
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68911881
76ABC transporters_Homo sapiens_hsa020100.67775826
77Rap1 signaling pathway_Homo sapiens_hsa040150.66021602
78Alcoholism_Homo sapiens_hsa050340.64281898
79Vitamin B6 metabolism_Homo sapiens_hsa007500.64019854
80Type I diabetes mellitus_Homo sapiens_hsa049400.63449533
81MAPK signaling pathway_Homo sapiens_hsa040100.63136729
82African trypanosomiasis_Homo sapiens_hsa051430.63025085
83Glucagon signaling pathway_Homo sapiens_hsa049220.61800974
84Peroxisome_Homo sapiens_hsa041460.61073588
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60305183
86* Choline metabolism in cancer_Homo sapiens_hsa052310.59857792
87VEGF signaling pathway_Homo sapiens_hsa043700.59756569
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56619714
89Ras signaling pathway_Homo sapiens_hsa040140.54802437
90Non-small cell lung cancer_Homo sapiens_hsa052230.54237416
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53267563
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.53069622
93Histidine metabolism_Homo sapiens_hsa003400.52638725
94Hedgehog signaling pathway_Homo sapiens_hsa043400.49534301
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.48660640
96Mineral absorption_Homo sapiens_hsa049780.48504654
97Bile secretion_Homo sapiens_hsa049760.48081542
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47530317
99Inositol phosphate metabolism_Homo sapiens_hsa005620.46717233
100Caffeine metabolism_Homo sapiens_hsa002320.46353635
101Circadian rhythm_Homo sapiens_hsa047100.46264282
102Alzheimers disease_Homo sapiens_hsa050100.46013687
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44518885
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.44369147
105Basal transcription factors_Homo sapiens_hsa030220.43744296
106mTOR signaling pathway_Homo sapiens_hsa041500.43584002
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43458589
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43270408
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.42574925
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41958409
111Prion diseases_Homo sapiens_hsa050200.40190778
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39330531
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38969409
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35392512
115Arginine and proline metabolism_Homo sapiens_hsa003300.35239570
116Chemokine signaling pathway_Homo sapiens_hsa040620.34176233
117Huntingtons disease_Homo sapiens_hsa050160.33768457
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33671491
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33584191
120Wnt signaling pathway_Homo sapiens_hsa043100.33577410
121Hippo signaling pathway_Homo sapiens_hsa043900.32864047
122Endocytosis_Homo sapiens_hsa041440.32827715
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30087457
124Fatty acid biosynthesis_Homo sapiens_hsa000610.30048362
125Fanconi anemia pathway_Homo sapiens_hsa034600.29140818
126Insulin signaling pathway_Homo sapiens_hsa049100.28501971
127Ovarian steroidogenesis_Homo sapiens_hsa049130.28219465
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28217656
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27428067
130Endometrial cancer_Homo sapiens_hsa052130.26820505
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26631102
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25987122
133Renal cell carcinoma_Homo sapiens_hsa052110.25105362
134Platelet activation_Homo sapiens_hsa046110.24777769
135Parkinsons disease_Homo sapiens_hsa050120.23243620
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22520794

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