DGKD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.94612561
2regulation of gamma-delta T cell differentiation (GO:0045586)5.22967281
3B cell receptor signaling pathway (GO:0050853)5.12358042
4negative regulation of cell killing (GO:0031342)5.03698277
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03698277
6regulation of gamma-delta T cell activation (GO:0046643)4.67595390
7positive thymic T cell selection (GO:0045059)4.37992841
8positive regulation of histone deacetylation (GO:0031065)4.32333279
9negative regulation of erythrocyte differentiation (GO:0045647)4.24062032
10positive regulation of B cell differentiation (GO:0045579)4.17817413
11positive regulation by symbiont of host defense response (GO:0052509)4.11516304
12modulation by symbiont of host defense response (GO:0052031)4.11516304
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11516304
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11516304
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.11516304
16modulation by symbiont of host immune response (GO:0052553)4.11516304
17leukocyte aggregation (GO:0070486)4.06172780
18detection of bacterium (GO:0016045)3.96070744
19detection of other organism (GO:0098543)3.93963812
20cellular extravasation (GO:0045123)3.87061509
21regulation of B cell receptor signaling pathway (GO:0050855)3.78247503
22positive T cell selection (GO:0043368)3.71498984
23neutrophil activation involved in immune response (GO:0002283)3.62510009
24regulation of B cell differentiation (GO:0045577)3.61581594
25negative regulation of histone methylation (GO:0031061)3.61454016
26response to muramyl dipeptide (GO:0032495)3.55211445
27germinal center formation (GO:0002467)3.50549748
28T cell selection (GO:0045058)3.46724809
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46544074
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45273242
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.43291914
32regulation of histone H3-K9 methylation (GO:0051570)3.39076185
33adaptation of signaling pathway (GO:0023058)3.36541304
34peptidyl-lysine dimethylation (GO:0018027)3.31463761
35cytoplasmic mRNA processing body assembly (GO:0033962)3.29235316
36antigen processing and presentation of endogenous antigen (GO:0019883)3.27197109
37regulation of ARF protein signal transduction (GO:0032012)3.27129967
38thymic T cell selection (GO:0045061)3.26519391
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.24694522
40serine transport (GO:0032329)3.24487827
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23880266
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23880266
43T cell migration (GO:0072678)3.19168674
44response to peptidoglycan (GO:0032494)3.19070835
45negative T cell selection (GO:0043383)3.16871422
46cellular response to interleukin-15 (GO:0071350)3.13857660
47histone H3-K9 demethylation (GO:0033169)3.13448843
48negative thymic T cell selection (GO:0045060)3.12575410
49L-serine transport (GO:0015825)3.12559478
50positive regulation of granulocyte differentiation (GO:0030854)3.11389617
51histone H3-K36 demethylation (GO:0070544)3.10599977
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07598267
53detection of external biotic stimulus (GO:0098581)3.07011204
54negative regulation of leukocyte mediated immunity (GO:0002704)3.06728399
55negative regulation of T cell mediated immunity (GO:0002710)3.03917072
56regulation of mast cell degranulation (GO:0043304)3.02690449
57antigen processing and presentation via MHC class Ib (GO:0002475)3.02187996
58pre-miRNA processing (GO:0031054)3.01253621
59positive regulation of protein deacetylation (GO:0090312)3.00953935
60antigen receptor-mediated signaling pathway (GO:0050851)2.99035794
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97965502
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97030474
63negative regulation of phagocytosis (GO:0050765)2.94688845
64activation of JUN kinase activity (GO:0007257)2.92842368
65mitotic sister chromatid cohesion (GO:0007064)2.91089481
66natural killer cell differentiation (GO:0001779)2.90538615
67regulation of NFAT protein import into nucleus (GO:0051532)2.90317594
68regulation of necroptotic process (GO:0060544)2.89744038
69immunoglobulin mediated immune response (GO:0016064)2.89221361
70histone H3-K4 trimethylation (GO:0080182)2.89123034
71regulation of interferon-beta biosynthetic process (GO:0045357)2.88556137
72V(D)J recombination (GO:0033151)2.86592036
73neutrophil activation (GO:0042119)2.86127511
74defense response to protozoan (GO:0042832)2.84943734
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84521071
76histone H3-K4 methylation (GO:0051568)2.83775207
77positive regulation of Rap GTPase activity (GO:0032854)2.83451983
78regulation of alpha-beta T cell proliferation (GO:0046640)2.82981394
79regulation of T-helper 2 cell differentiation (GO:0045628)2.82202696
80negative regulation of granulocyte differentiation (GO:0030853)2.82036718
81regulation of leukocyte degranulation (GO:0043300)2.81465820
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79769386
83regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79432194
84cortical actin cytoskeleton organization (GO:0030866)2.78566853
85response to host (GO:0075136)2.77361882
86response to host defenses (GO:0052200)2.77361882
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77361882
88peptidyl-threonine phosphorylation (GO:0018107)2.77294205
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76527730
90negative regulation of T-helper cell differentiation (GO:0045623)2.76527730
91respiratory burst (GO:0045730)2.76167597
92regulation of mast cell activation involved in immune response (GO:0033006)2.73979925
93NLS-bearing protein import into nucleus (GO:0006607)2.73707874
94regulation of ARF GTPase activity (GO:0032312)2.73625944
95peptidyl-threonine modification (GO:0018210)2.73008775
96myeloid cell activation involved in immune response (GO:0002275)2.72520962
97detection of biotic stimulus (GO:0009595)2.72498009
98regulation of histone H3-K27 methylation (GO:0061085)2.72435347
99B cell proliferation (GO:0042100)2.72306027
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70775898
101response to host immune response (GO:0052572)2.70775898
102positive regulation of gene expression, epigenetic (GO:0045815)2.70543355
103regulation of granulocyte differentiation (GO:0030852)2.67940993
104sodium ion export (GO:0071436)2.66372665
1053-UTR-mediated mRNA stabilization (GO:0070935)2.66306568
106megakaryocyte development (GO:0035855)2.66271885
107germ cell migration (GO:0008354)2.65826512
108leukocyte migration involved in inflammatory response (GO:0002523)2.65362372
109protein localization to endosome (GO:0036010)2.63511728
110regulation of T cell tolerance induction (GO:0002664)2.62947514
111response to laminar fluid shear stress (GO:0034616)2.62893570
112signal complex assembly (GO:0007172)2.61612646
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60443760
114macrophage activation involved in immune response (GO:0002281)2.59734296
115CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58639376
116negative regulation of bone resorption (GO:0045779)2.56188651
117regulation of nucleobase-containing compound transport (GO:0032239)2.56179530
118production of molecular mediator involved in inflammatory response (GO:0002532)2.56037555
119immune response-activating cell surface receptor signaling pathway (GO:0002429)2.55117111
120response to interleukin-15 (GO:0070672)2.54516959
121T cell costimulation (GO:0031295)2.54393248
122chromatin silencing (GO:0006342)2.53359962
123regulation of RNA export from nucleus (GO:0046831)2.53196649
124response to protozoan (GO:0001562)2.52981314
125B cell homeostasis (GO:0001782)2.52389387
126histone H4-K16 acetylation (GO:0043984)2.52154615
127hepatocyte apoptotic process (GO:0097284)2.51108281
128regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50508897
129tolerance induction (GO:0002507)2.49778563
130immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.48872949
131Fc-gamma receptor signaling pathway (GO:0038094)2.48872949
132Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.48872949
133regulation of histone deacetylation (GO:0031063)2.47613566
134histone lysine methylation (GO:0034968)2.47124796
135lymphocyte costimulation (GO:0031294)2.46815619
136histone lysine demethylation (GO:0070076)2.46409734
137Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.44954130
138negative regulation of gene expression, epigenetic (GO:0045814)2.43521906
139lymphocyte homeostasis (GO:0002260)2.43505161
140T cell homeostasis (GO:0043029)2.43259765
141nuclear pore complex assembly (GO:0051292)2.43062616
142T cell receptor signaling pathway (GO:0050852)2.41347227
143mannose metabolic process (GO:0006013)2.40798889
144peptidyl-lysine trimethylation (GO:0018023)2.40762889
145phosphatidylinositol dephosphorylation (GO:0046856)2.39099005
146activated T cell proliferation (GO:0050798)2.38322036
147lipid phosphorylation (GO:0046834)2.36818162
148regulation of Rap GTPase activity (GO:0032317)2.36460093
149protein-DNA complex disassembly (GO:0032986)2.36041545
150nucleosome disassembly (GO:0006337)2.36041545
151gene silencing (GO:0016458)2.35553669
152negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33673526
153cellular response to zinc ion (GO:0071294)2.33229253
154glucocorticoid receptor signaling pathway (GO:0042921)2.32801111
155histone demethylation (GO:0016577)2.31729089
156negative regulation of B cell proliferation (GO:0030889)2.30785468
157peptidyl-lysine methylation (GO:0018022)2.30057201
158mature B cell differentiation (GO:0002335)2.29717671
159negative regulation of cell size (GO:0045792)2.29282772
160RNA stabilization (GO:0043489)2.28749502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_22102868_ChIP-Seq_BL_Human4.48660517
2E2F7_22180533_ChIP-Seq_HELA_Human4.04611900
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74324239
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68898944
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58008670
6VDR_21846776_ChIP-Seq_THP-1_Human3.27251930
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.22280750
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.15105227
9TCF7_22412390_ChIP-Seq_EML_Mouse2.92530111
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.87551113
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81004361
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.76790624
13KDM2B_26808549_Chip-Seq_DND41_Human2.75807412
14RUNX_20019798_ChIP-Seq_JUKART_Human2.60274035
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59787995
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.57957948
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.57403200
18* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.56544726
19UTX_26944678_Chip-Seq_JUKART_Human2.42361342
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40743524
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39708013
22MAF_26560356_Chip-Seq_TH1_Human2.33814389
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.33556792
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32507872
25SPI1_23127762_ChIP-Seq_K562_Human2.17440960
26MYB_26560356_Chip-Seq_TH2_Human2.17218037
27VDR_24763502_ChIP-Seq_THP-1_Human2.08200689
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06594635
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05878183
30* MYB_26560356_Chip-Seq_TH1_Human2.05211086
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01366219
32* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01171541
33SCL_19346495_ChIP-Seq_HPC-7_Human1.99579256
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90410466
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89889118
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85485833
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.81058060
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78169557
39CIITA_25753668_ChIP-Seq_RAJI_Human1.77575019
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73036252
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72739701
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70998998
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69291872
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.67899467
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66757770
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.64906474
47* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63522464
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62521875
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59726727
50GATA3_27048872_Chip-Seq_THYMUS_Human1.58054713
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56370748
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48512626
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48436721
54KDM2B_26808549_Chip-Seq_K562_Human1.42576921
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.42030264
56MAF_26560356_Chip-Seq_TH2_Human1.39974720
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36685686
58RACK7_27058665_Chip-Seq_MCF-7_Human1.31777189
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30220442
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28072316
61LXR_22292898_ChIP-Seq_THP-1_Human1.26585274
62GATA1_22025678_ChIP-Seq_K562_Human1.26335505
63SMC4_20622854_ChIP-Seq_HELA_Human1.24788156
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24311562
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23269828
66P68_20966046_ChIP-Seq_HELA_Human1.20983642
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20856985
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19550042
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18897069
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17278656
71NCOR1_26117541_ChIP-Seq_K562_Human1.16852873
72* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16284516
73SPI1_23547873_ChIP-Seq_NB4_Human1.16030418
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14721390
75BCOR_27268052_Chip-Seq_Bcells_Human1.14713494
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14325156
77* RARB_27405468_Chip-Seq_BRAIN_Mouse1.14211321
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12601665
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11113951
80DROSHA_22980978_ChIP-Seq_HELA_Human1.10978791
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.10724750
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10605204
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.07322276
84BCL6_27268052_Chip-Seq_Bcells_Human1.07247695
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06938800
86GATA1_19941826_ChIP-Seq_K562_Human1.06552037
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06258733
88* PU_27001747_Chip-Seq_BMDM_Mouse1.06093323
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.05918460
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.05202332
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04939360
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04394336
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04056585
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.03512501
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01443074
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00102419
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99372598
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.99324983
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97529398
100* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97224901
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96761503
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96595154
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96525332
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.95658330
105CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95290556
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95141147
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92970351
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92628565
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92273771
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91073731
111VDR_24787735_ChIP-Seq_THP-1_Human0.90400630
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90391246
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90230312
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89596259
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88733359
116GATA2_19941826_ChIP-Seq_K562_Human0.88711445
117E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87770154
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87655673
119CREB1_26743006_Chip-Seq_LNCaP_Human0.85916633
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85819880
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85584215
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.85042373
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82906587
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80446525
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80442683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.91333219
2MP0003300_gastrointestinal_ulcer3.15834383
3MP0003303_peritoneal_inflammation3.09636034
4MP0001800_abnormal_humoral_immune2.84475376
5MP0003724_increased_susceptibility_to2.79319181
6MP0005451_abnormal_body_composition2.71811394
7MP0001835_abnormal_antigen_presentation2.62135313
8MP0002166_altered_tumor_susceptibility2.55135469
9MP0005076_abnormal_cell_differentiation2.48372455
10MP0001790_abnormal_immune_system2.42638281
11MP0005387_immune_system_phenotype2.42638281
12MP0003183_abnormal_peptide_metabolism2.33329232
13MP0003763_abnormal_thymus_physiology2.29899231
14MP0000685_abnormal_immune_system2.29812056
15MP0008961_abnormal_basal_metabolism2.25569915
16MP0002398_abnormal_bone_marrow2.22645554
17MP0002452_abnormal_antigen_presenting2.21518451
18MP0008260_abnormal_autophagy2.16578873
19MP0009278_abnormal_bone_marrow2.13089737
20MP0002396_abnormal_hematopoietic_system2.02608870
21MP0002420_abnormal_adaptive_immunity2.02340357
22MP0005670_abnormal_white_adipose2.00119596
23MP0001819_abnormal_immune_cell1.98643085
24MP0000703_abnormal_thymus_morphology1.97556679
25MP0004808_abnormal_hematopoietic_stem1.93879656
26MP0002723_abnormal_immune_serum1.88598150
27MP0003172_abnormal_lysosome_physiology1.86096342
28MP0010234_abnormal_vibrissa_follicle1.84877383
29MP0003787_abnormal_imprinting1.84796188
30MP0000689_abnormal_spleen_morphology1.83513887
31MP0000716_abnormal_immune_system1.83369342
32MP0008877_abnormal_DNA_methylation1.79519503
33MP0010352_gastrointestinal_tract_polyps1.77648423
34MP0002009_preneoplasia1.77076538
35MP0003866_abnormal_defecation1.76754276
36MP0005671_abnormal_response_to1.75902164
37MP0003828_pulmonary_edema1.72844709
38MP0002722_abnormal_immune_system1.71524808
39MP0005000_abnormal_immune_tolerance1.71284460
40MP0010307_abnormal_tumor_latency1.69662003
41MP0001873_stomach_inflammation1.67457464
42MP0002006_tumorigenesis1.66713408
43MP0004185_abnormal_adipocyte_glucose1.65592634
44MP0005666_abnormal_adipose_tissue1.64834398
45MP0004130_abnormal_muscle_cell1.59183538
46MP0009785_altered_susceptibility_to1.56567232
47MP0004381_abnormal_hair_follicle1.56294891
48MP0003045_fibrosis1.55294821
49MP0005375_adipose_tissue_phenotype1.49086831
50MP0002429_abnormal_blood_cell1.48797145
51MP0004510_myositis1.48567875
52MP0003436_decreased_susceptibility_to1.48076223
53MP0002132_abnormal_respiratory_system1.47933929
54MP0004947_skin_inflammation1.42114531
55MP0003646_muscle_fatigue1.40847139
56MP0000003_abnormal_adipose_tissue1.35297847
57MP0001533_abnormal_skeleton_physiology1.34696617
58MP0005174_abnormal_tail_pigmentation1.32249629
59MP0010155_abnormal_intestine_physiology1.28120596
60MP0005409_darkened_coat_color1.27333491
61MP0005464_abnormal_platelet_physiology1.27257436
62MP0002405_respiratory_system_inflammati1.25728174
63MP0004036_abnormal_muscle_relaxation1.22040849
64MP0003705_abnormal_hypodermis_morpholog1.18966268
65MP0002419_abnormal_innate_immunity1.16129303
66MP0004859_abnormal_synaptic_plasticity1.14492519
67MP0002148_abnormal_hypersensitivity_rea1.12839348
68MP0000465_gastrointestinal_hemorrhage1.12714981
69MP0002998_abnormal_bone_remodeling1.09244016
70MP0005025_abnormal_response_to1.07586509
71MP0002138_abnormal_hepatobiliary_system1.07563279
72MP0002909_abnormal_adrenal_gland1.07058562
73MP0008569_lethality_at_weaning1.05847098
74MP0005397_hematopoietic_system_phenotyp1.05061526
75MP0001545_abnormal_hematopoietic_system1.05061526
76MP0004087_abnormal_muscle_fiber1.02968162
77MP0000858_altered_metastatic_potential0.97683239
78MP0003091_abnormal_cell_migration0.97497505
79MP0005058_abnormal_lysosome_morphology0.96116657
80MP0001348_abnormal_lacrimal_gland0.95067221
81MP0002332_abnormal_exercise_endurance0.95050474
82MP0004084_abnormal_cardiac_muscle0.94517145
83MP0000015_abnormal_ear_pigmentation0.94162541
84MP0006054_spinal_hemorrhage0.94130763
85MP0010094_abnormal_chromosome_stability0.94095002
86MP0001845_abnormal_inflammatory_respons0.94055585
87MP0002928_abnormal_bile_duct0.93524980
88MP0008469_abnormal_protein_level0.91680754
89MP0000013_abnormal_adipose_tissue0.91449575
90MP0005310_abnormal_salivary_gland0.90917098
91MP0008004_abnormal_stomach_pH0.90882622
92MP0006138_congestive_heart_failure0.90681849
93MP0009780_abnormal_chondrocyte_physiolo0.88457199
94MP0003191_abnormal_cellular_cholesterol0.88194204
95MP0000747_muscle_weakness0.87968145
96MP0001663_abnormal_digestive_system0.86184728
97MP0009115_abnormal_fat_cell0.85800753
98MP0004233_abnormal_muscle_weight0.85741361
99MP0000733_abnormal_muscle_development0.85350948
100MP0001730_embryonic_growth_arrest0.84193781
101MP0000759_abnormal_skeletal_muscle0.84190680
102MP0003566_abnormal_cell_adhesion0.82962942
103MP0000751_myopathy0.82872076
104* MP0002019_abnormal_tumor_incidence0.81990410
105MP0002970_abnormal_white_adipose0.79111785
106MP0001849_ear_inflammation0.78888541
107MP0002971_abnormal_brown_adipose0.77769169
108MP0002106_abnormal_muscle_physiology0.77436885
109MP0000604_amyloidosis0.76952070
110MP0008874_decreased_physiological_sensi0.76817879
111MP0001853_heart_inflammation0.76341753
112MP0004484_altered_response_of0.75727945
113MP0000490_abnormal_crypts_of0.75645295
114MP0003656_abnormal_erythrocyte_physiolo0.75204723
115MP0000350_abnormal_cell_proliferation0.74578580
116MP0005621_abnormal_cell_physiology0.73390692
117MP0004883_abnormal_blood_vessel0.73347289
118MP0010630_abnormal_cardiac_muscle0.73273483
119MP0000249_abnormal_blood_vessel0.72717857
120MP0003111_abnormal_nucleus_morphology0.70562231
121MP0009333_abnormal_splenocyte_physiolog0.70372750
122MP0000371_diluted_coat_color0.69282930
123MP0003077_abnormal_cell_cycle0.68371956
124MP0003221_abnormal_cardiomyocyte_apopto0.68232568
125MP0005083_abnormal_biliary_tract0.67889481
126MP0008057_abnormal_DNA_replication0.66664905
127MP0001879_abnormal_lymphatic_vessel0.65760052
128MP0001915_intracranial_hemorrhage0.65712747
129MP0005410_abnormal_fertilization0.64788154
130MP0006082_CNS_inflammation0.64147165
131MP0005166_decreased_susceptibility_to0.63784680
132MP0003984_embryonic_growth_retardation0.62437135
133MP0002933_joint_inflammation0.62228453
134MP0000749_muscle_degeneration0.61792016
135MP0005334_abnormal_fat_pad0.61229853
136MP0002877_abnormal_melanocyte_morpholog0.60221901
137MP0002088_abnormal_embryonic_growth/wei0.60035539
138MP0001851_eye_inflammation0.59041543

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.66274331
2Verrucae (HP:0200043)4.31448102
3Papilloma (HP:0012740)4.31448102
4Cellulitis (HP:0100658)3.95227433
5Thyroiditis (HP:0100646)3.86294427
6Recurrent viral infections (HP:0004429)3.85483971
7Colitis (HP:0002583)3.83499264
8Prolonged bleeding time (HP:0003010)3.81692526
9B lymphocytopenia (HP:0010976)3.79471314
10Abnormality of B cell number (HP:0010975)3.79471314
11Abnormality of the fingertips (HP:0001211)3.79244522
12Panhypogammaglobulinemia (HP:0003139)3.50232831
13Abnormality of macrophages (HP:0004311)3.49308610
14Recurrent bronchitis (HP:0002837)3.41568427
15Myositis (HP:0100614)3.33765222
16Inflammation of the large intestine (HP:0002037)3.32168517
17Gastrointestinal inflammation (HP:0004386)3.31041657
18T lymphocytopenia (HP:0005403)3.28782995
19Exercise-induced myalgia (HP:0003738)3.17450627
20Recurrent gram-negative bacterial infections (HP:0005420)3.13089872
21Gastrointestinal infarctions (HP:0005244)3.10747699
22Increased IgE level (HP:0003212)3.08254945
23Obstructive lung disease (HP:0006536)3.06520378
24Chronic obstructive pulmonary disease (HP:0006510)3.06520378
25Abnormality of T cell number (HP:0011839)3.01528791
26Vertebral arch anomaly (HP:0008438)3.01497407
27Vasculitis (HP:0002633)2.99601050
28Hyperacusis (HP:0010780)2.99447012
29Broad face (HP:0000283)2.95129696
30Muscle fiber inclusion bodies (HP:0100299)2.90419619
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.88491433
32Orchitis (HP:0100796)2.88479513
33Pustule (HP:0200039)2.86434278
34Macroorchidism (HP:0000053)2.85217317
35Recurrent fungal infections (HP:0002841)2.84127607
36Optic neuritis (HP:0100653)2.80968155
37Retrobulbar optic neuritis (HP:0100654)2.80968155
38Epistaxis (HP:0000421)2.80532000
39Encephalitis (HP:0002383)2.79099468
40Chest pain (HP:0100749)2.78171122
41Distal lower limb amyotrophy (HP:0008944)2.74500407
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.73854611
43Gingivitis (HP:0000230)2.73735384
44Obstructive sleep apnea (HP:0002870)2.72229095
45Recurrent skin infections (HP:0001581)2.65731888
46Elevated erythrocyte sedimentation rate (HP:0003565)2.64467320
47Severe combined immunodeficiency (HP:0004430)2.62323608
48Stomatitis (HP:0010280)2.57656657
49Meningitis (HP:0001287)2.55324263
50Recurrent sinusitis (HP:0011108)2.54421453
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.54190981
52Combined immunodeficiency (HP:0005387)2.53945876
53Nemaline bodies (HP:0003798)2.53450793
54Heterotopia (HP:0002282)2.53356639
55Cerebral aneurysm (HP:0004944)2.51206744
56Dysmetric saccades (HP:0000641)2.48625986
57Osteomyelitis (HP:0002754)2.47244113
58Hypoplasia of the thymus (HP:0000778)2.45743223
59IgM deficiency (HP:0002850)2.44166199
60Gastrointestinal stroma tumor (HP:0100723)2.39011777
61Volvulus (HP:0002580)2.32674927
62Autoimmune thrombocytopenia (HP:0001973)2.31531194
63Increased connective tissue (HP:0009025)2.28600085
64Hematochezia (HP:0002573)2.27031156
65Recurrent otitis media (HP:0000403)2.26200786
66Facial diplegia (HP:0001349)2.24589935
67Easy fatigability (HP:0003388)2.23559492
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23284433
69Gingival bleeding (HP:0000225)2.21439984
70Hypochromic anemia (HP:0001931)2.20876018
71Papilledema (HP:0001085)2.18733975
72Slow saccadic eye movements (HP:0000514)2.15874123
73Lymphopenia (HP:0001888)2.15224278
74Hyporeflexia of lower limbs (HP:0002600)2.15085031
75Muscle fiber splitting (HP:0003555)2.14772778
76Sepsis (HP:0100806)2.13656316
77Pulmonary infiltrates (HP:0002113)2.13621031
78Eosinophilia (HP:0001880)2.11627253
79Myopathic facies (HP:0002058)2.09495818
80Menorrhagia (HP:0000132)2.08780138
81Abnormal platelet volume (HP:0011876)2.08657998
82Abnormality of T cells (HP:0002843)2.08402867
83Truncal obesity (HP:0001956)2.08257842
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.07779726
85Bronchitis (HP:0012387)2.02355928
86Abnormality of T cell physiology (HP:0011840)2.01995740
87Disinhibition (HP:0000734)2.01171498
88Small epiphyses (HP:0010585)2.00718755
89Chronic sinusitis (HP:0011109)1.99247407
90Keratoconjunctivitis sicca (HP:0001097)1.98800600
91Recurrent abscess formation (HP:0002722)1.98320103
92Hemorrhage of the eye (HP:0011885)1.98018011
93Arterial thrombosis (HP:0004420)1.97890244
94Hemoptysis (HP:0002105)1.96811037
95Dislocated radial head (HP:0003083)1.96364785
96Hand muscle atrophy (HP:0009130)1.96178111
97Fatigue (HP:0012378)1.95282425
98Abnormality of the lower motor neuron (HP:0002366)1.95083575
99Nasal polyposis (HP:0100582)1.94169679
100Abnormality of skeletal muscle fiber size (HP:0012084)1.93947612
101Long eyelashes (HP:0000527)1.93732926
102EMG: myopathic abnormalities (HP:0003458)1.93559523
103Recurrent bacterial skin infections (HP:0005406)1.93064178
104Leukocytosis (HP:0001974)1.92652012
105Chronic otitis media (HP:0000389)1.92323664
106Viral hepatitis (HP:0006562)1.91847021
107Hemiplegia (HP:0002301)1.90897883
108Prominent nose (HP:0000448)1.90507816
109Petechiae (HP:0000967)1.88504969
110Urticaria (HP:0001025)1.88272579
111Emphysema (HP:0002097)1.86626838
112Elfin facies (HP:0004428)1.86293260
113Abnormality of the endocardium (HP:0004306)1.85864521
114Flattened epiphyses (HP:0003071)1.85584170
115Subacute progressive viral hepatitis (HP:0006572)1.85176115
116Absent frontal sinuses (HP:0002688)1.82161193
117Pointed chin (HP:0000307)1.81863248
118Chronic mucocutaneous candidiasis (HP:0002728)1.81475325
119Recurrent cutaneous fungal infections (HP:0011370)1.81475325
120Pulmonary embolism (HP:0002204)1.81269656
121Ulnar bowing (HP:0003031)1.80677641
122Abnormality of the radial head (HP:0003995)1.79702144
123Abnormality of the columella (HP:0009929)1.79332953
124Episodic fever (HP:0001954)1.79076594
125Lower limb amyotrophy (HP:0007210)1.78380966
126Ulnar deviation of the wrist (HP:0003049)1.78260555
127Narrow palate (HP:0000189)1.77797802
128Resting tremor (HP:0002322)1.77597597
129Increased density of long bones (HP:0006392)1.77496526
130Keratoconjunctivitis (HP:0001096)1.76371155
131Cutaneous melanoma (HP:0012056)1.75334557
132Abnormality of ocular smooth pursuit (HP:0000617)1.75142153
133Abnormality of eosinophils (HP:0001879)1.74209715
134Onion bulb formation (HP:0003383)1.74199888
135Increased variability in muscle fiber diameter (HP:0003557)1.74177358
136Aqueductal stenosis (HP:0002410)1.73379191
137Basal cell carcinoma (HP:0002671)1.73095749
138Impaired smooth pursuit (HP:0007772)1.72914195
139Aortic aneurysm (HP:0004942)1.71771995
140High pitched voice (HP:0001620)1.71650491
141Upper limb amyotrophy (HP:0009129)1.71209231
142Distal upper limb amyotrophy (HP:0007149)1.71209231
143Cutis marmorata (HP:0000965)1.70768232
144Inappropriate behavior (HP:0000719)1.70733840
145Restrictive lung disease (HP:0002091)1.70557057
146Urethral obstruction (HP:0000796)1.68150849
147Abnormality of the intervertebral disk (HP:0005108)1.67218447
148Obsessive-compulsive behavior (HP:0000722)1.66980302
149Sandal gap (HP:0001852)1.63685512
150Increased CSF protein (HP:0002922)1.63452096
151Spontaneous hematomas (HP:0007420)1.63317087
152Eczematoid dermatitis (HP:0000976)1.63231408
153Mediastinal lymphadenopathy (HP:0100721)1.62490468
154Chronic diarrhea (HP:0002028)1.61000069
155Granulocytopenia (HP:0001913)1.59297855
156Transitional cell carcinoma of the bladder (HP:0006740)1.59136924
157Frequent falls (HP:0002359)1.57644830
158Difficulty running (HP:0009046)1.57387373
159Increased cerebral lipofuscin (HP:0011813)1.57028092
160Striae distensae (HP:0001065)1.55967713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.20708014
2PRPF4B3.78109088
3MAP4K13.69927920
4EEF2K3.62031301
5TRIB33.05707332
6CDK122.80269380
7GRK62.68042523
8PKN22.57799280
9SIK22.35625611
10CAMK1G2.29584957
11CAMK1D2.14382122
12IRAK41.91613382
13ERN11.88471287
14TNK21.88344734
15RIPK11.83299559
16RIPK41.57493502
17STK101.57128975
18CSF1R1.56557052
19NEK21.47873606
20SYK1.45972765
21PTK61.44275064
22BRD41.42703579
23ITK1.38818727
24MAP3K141.34951551
25MAP3K131.34683210
26CDK91.34647206
27FGFR31.33524411
28SIK31.26944423
29HCK1.25191274
30JAK11.24669582
31BTK1.22676661
32ICK1.22523186
33SMG11.22169485
34TYK21.19045898
35SCYL21.17043972
36ALK1.14040960
37CDK41.13853760
38FES1.12521894
39MAP3K11.11443271
40MAP3K71.09259469
41LRRK21.08261300
42MAP3K91.05155804
43ZAP701.02527330
44CDC42BPA1.02384559
45WNK11.00658616
46PRKCH1.00019509
47TXK0.99698652
48TTN0.97708299
49PDK10.95887752
50SGK30.95010073
51SIK10.94635941
52MAP3K30.93914036
53OBSCN0.93743756
54IKBKE0.93592758
55MAP3K110.93279002
56CDK60.92908526
57FGFR20.89908942
58FGR0.89358964
59MTOR0.87664187
60CSK0.86673924
61LCK0.85534828
62PRKD30.85144335
63CLK10.85032207
64MARK20.80399705
65RET0.80170258
66HIPK20.78803468
67PDGFRB0.78198988
68TGFBR20.75839001
69CAMKK10.74896101
70FGFR40.74368657
71TYRO30.73094555
72FRK0.69667108
73YES10.69546336
74STK40.68511703
75DYRK1B0.67801807
76JAK30.67751753
77MAPK120.67106697
78TAOK10.66529572
79PIM10.66119200
80PIK3CG0.65633891
81STK110.64976866
82MAPK70.64914512
83KSR20.64866257
84IRAK20.64348391
85RPS6KL10.64020530
86RPS6KC10.64020530
87KIT0.62920181
88MELK0.61856525
89MARK30.61745183
90TEC0.60383441
91BMPR20.60284300
92IKBKB0.60145823
93EPHB10.59786245
94JAK20.59179715
95MAP2K30.58476909
96TAOK20.58395256
97PRKD20.57459929
98CDC70.57057485
99RPS6KA20.52289988
100RPS6KA60.52097688
101PDK30.52010341
102PDK40.52010341
103CAMK40.51042925
104LYN0.50724348
105PRKD10.49973791
106BMX0.48972848
107PASK0.48869994
108PDPK10.48651313
109FYN0.48043713
110RPS6KB10.47856605
111DMPK0.46924709
112IRAK10.45573571
113MAP2K20.44286421
114EGFR0.43544320
115PRKAA10.43248698
116MAPK110.41981904
117CHEK10.41632785
118RPS6KB20.41606498
119TBK10.41377471
120TRPM70.40619655
121PTK2B0.40277679
122PDGFRA0.39799039
123DAPK20.39525331
124CSNK1D0.39154658
125MAP3K80.39123678
126BLK0.39111018
127NLK0.38932026
128CHUK0.38915590
129MAPK40.38731120
130SGK20.38258778
131TAOK30.37586313
132ATR0.37116075
133PRKCQ0.36758917
134STK380.36581330

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.10722465
2Primary immunodeficiency_Homo sapiens_hsa053402.85670930
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95093914
4Osteoclast differentiation_Homo sapiens_hsa043801.78123090
5Graft-versus-host disease_Homo sapiens_hsa053321.77949555
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76836098
7Allograft rejection_Homo sapiens_hsa053301.76494977
8T cell receptor signaling pathway_Homo sapiens_hsa046601.73988499
9Autoimmune thyroid disease_Homo sapiens_hsa053201.70537966
10Chronic myeloid leukemia_Homo sapiens_hsa052201.63108362
11Type II diabetes mellitus_Homo sapiens_hsa049301.62037810
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56379522
13Non-small cell lung cancer_Homo sapiens_hsa052231.55058873
14* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52801028
15mTOR signaling pathway_Homo sapiens_hsa041501.50757102
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46620976
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42981386
18Staphylococcus aureus infection_Homo sapiens_hsa051501.41858674
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41296435
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33813477
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.32763006
22Other glycan degradation_Homo sapiens_hsa005111.28358143
23Pancreatic cancer_Homo sapiens_hsa052121.26472241
24Glioma_Homo sapiens_hsa052141.25088868
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.23704629
26Lysine degradation_Homo sapiens_hsa003101.23017872
27Acute myeloid leukemia_Homo sapiens_hsa052211.22800584
28VEGF signaling pathway_Homo sapiens_hsa043701.21741694
29Long-term potentiation_Homo sapiens_hsa047201.20937750
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18743950
31Type I diabetes mellitus_Homo sapiens_hsa049401.18682072
32Inositol phosphate metabolism_Homo sapiens_hsa005621.18472774
33Chemokine signaling pathway_Homo sapiens_hsa040621.17426302
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14473357
35Dorso-ventral axis formation_Homo sapiens_hsa043201.12581195
36Colorectal cancer_Homo sapiens_hsa052101.10785990
37Insulin resistance_Homo sapiens_hsa049311.10676479
38Platelet activation_Homo sapiens_hsa046111.10612554
39Antigen processing and presentation_Homo sapiens_hsa046121.06531128
40TNF signaling pathway_Homo sapiens_hsa046681.06166275
41Endometrial cancer_Homo sapiens_hsa052131.06001167
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05338310
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04737123
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04498967
45Toxoplasmosis_Homo sapiens_hsa051451.02305422
46Leishmaniasis_Homo sapiens_hsa051401.01157588
47Estrogen signaling pathway_Homo sapiens_hsa049151.00508519
48Asthma_Homo sapiens_hsa053101.00313354
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99762978
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99161627
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.98473206
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95204500
53Measles_Homo sapiens_hsa051620.94485018
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93988130
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93765872
56Hepatitis B_Homo sapiens_hsa051610.93615378
57Hepatitis C_Homo sapiens_hsa051600.92819841
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91637971
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.91445984
60Renin secretion_Homo sapiens_hsa049240.91161939
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91038168
62Viral carcinogenesis_Homo sapiens_hsa052030.90026889
63Hematopoietic cell lineage_Homo sapiens_hsa046400.89297253
64Renal cell carcinoma_Homo sapiens_hsa052110.88859661
65Insulin signaling pathway_Homo sapiens_hsa049100.88027960
66Gastric acid secretion_Homo sapiens_hsa049710.87822783
67FoxO signaling pathway_Homo sapiens_hsa040680.86194818
68* Phospholipase D signaling pathway_Homo sapiens_hsa040720.85307670
69AMPK signaling pathway_Homo sapiens_hsa041520.83818060
70Tuberculosis_Homo sapiens_hsa051520.83352451
71Oxytocin signaling pathway_Homo sapiens_hsa049210.82758940
72Endocytosis_Homo sapiens_hsa041440.81793464
73Small cell lung cancer_Homo sapiens_hsa052220.81673577
74Glucagon signaling pathway_Homo sapiens_hsa049220.80356984
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79932296
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79025423
77Salivary secretion_Homo sapiens_hsa049700.78841432
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78576739
79HTLV-I infection_Homo sapiens_hsa051660.78519142
80Malaria_Homo sapiens_hsa051440.78352611
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.78015278
82Viral myocarditis_Homo sapiens_hsa054160.77469734
83Apoptosis_Homo sapiens_hsa042100.77329809
84MAPK signaling pathway_Homo sapiens_hsa040100.76423090
85Influenza A_Homo sapiens_hsa051640.75389700
86ErbB signaling pathway_Homo sapiens_hsa040120.74995226
87Olfactory transduction_Homo sapiens_hsa047400.74556832
88MicroRNAs in cancer_Homo sapiens_hsa052060.74282240
89Non-homologous end-joining_Homo sapiens_hsa034500.74205934
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73164041
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72800890
92Morphine addiction_Homo sapiens_hsa050320.72783059
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72541860
94GnRH signaling pathway_Homo sapiens_hsa049120.71094688
95Notch signaling pathway_Homo sapiens_hsa043300.70737069
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.70372471
97HIF-1 signaling pathway_Homo sapiens_hsa040660.70363577
98Cholinergic synapse_Homo sapiens_hsa047250.69580829
99Prolactin signaling pathway_Homo sapiens_hsa049170.68881486
100Proteoglycans in cancer_Homo sapiens_hsa052050.67612585
101Epstein-Barr virus infection_Homo sapiens_hsa051690.66644177
102* Choline metabolism in cancer_Homo sapiens_hsa052310.66379216
103mRNA surveillance pathway_Homo sapiens_hsa030150.65773159
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.65497687
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64398820
106Circadian entrainment_Homo sapiens_hsa047130.63480205
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62712111
108Herpes simplex infection_Homo sapiens_hsa051680.62311577
109Pancreatic secretion_Homo sapiens_hsa049720.60783808
110Thyroid cancer_Homo sapiens_hsa052160.60537978
111Prostate cancer_Homo sapiens_hsa052150.60335265
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60228655
113cAMP signaling pathway_Homo sapiens_hsa040240.57827932
114Long-term depression_Homo sapiens_hsa047300.57587942
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57208617
116Shigellosis_Homo sapiens_hsa051310.56914778
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.56625112
118Phagosome_Homo sapiens_hsa041450.51940841
119Rap1 signaling pathway_Homo sapiens_hsa040150.51004726
120* Glycerophospholipid metabolism_Homo sapiens_hsa005640.49325721
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48874645
122African trypanosomiasis_Homo sapiens_hsa051430.47458578
123Legionellosis_Homo sapiens_hsa051340.45649588

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