DGKG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.93961729
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.76822041
3glutamate receptor signaling pathway (GO:0007215)5.52333363
4vocalization behavior (GO:0071625)5.51272662
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.33444512
6synaptic vesicle exocytosis (GO:0016079)5.28109285
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.26250365
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.23503850
9neuronal action potential propagation (GO:0019227)5.22366248
10regulation of glutamate receptor signaling pathway (GO:1900449)5.17001059
11protein localization to synapse (GO:0035418)5.00966341
12synaptic transmission, glutamatergic (GO:0035249)4.96568169
13locomotory exploration behavior (GO:0035641)4.84111446
14neuron-neuron synaptic transmission (GO:0007270)4.64357113
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.64216479
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62288358
17synaptic vesicle maturation (GO:0016188)4.49780070
18regulation of synaptic vesicle exocytosis (GO:2000300)4.49751755
19regulation of beta-amyloid formation (GO:1902003)4.48400194
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.47677283
21positive regulation of dendritic spine morphogenesis (GO:0061003)4.40116986
22glutamate secretion (GO:0014047)4.39154072
23neuron cell-cell adhesion (GO:0007158)4.37015071
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32589064
25long-term memory (GO:0007616)4.32202500
26exploration behavior (GO:0035640)4.30687375
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.30228355
28regulation of synaptic vesicle transport (GO:1902803)4.23099907
29L-amino acid import (GO:0043092)4.18901317
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.18780410
31regulation of neuronal synaptic plasticity (GO:0048168)4.12987046
32positive regulation of membrane potential (GO:0045838)4.08591489
33positive regulation of synapse maturation (GO:0090129)4.07556361
34neurotransmitter-gated ion channel clustering (GO:0072578)4.01565574
35synaptic vesicle endocytosis (GO:0048488)4.01512860
36regulation of postsynaptic membrane potential (GO:0060078)4.00720685
37neurotransmitter secretion (GO:0007269)4.00450553
38neurotransmitter uptake (GO:0001504)3.94803524
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93172550
40cellular potassium ion homeostasis (GO:0030007)3.91531111
41regulation of amyloid precursor protein catabolic process (GO:1902991)3.87253991
42presynaptic membrane assembly (GO:0097105)3.87003152
43postsynaptic membrane organization (GO:0001941)3.86304622
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.85264371
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.84390956
46long-term synaptic potentiation (GO:0060291)3.79958198
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73145285
48regulation of synaptic plasticity (GO:0048167)3.66684110
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.66442842
50negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.64299202
51response to histamine (GO:0034776)3.63604322
52behavioral defense response (GO:0002209)3.63604292
53behavioral fear response (GO:0001662)3.63604292
54positive regulation of dendritic spine development (GO:0060999)3.60822781
55protein prenylation (GO:0018342)3.56679706
56prenylation (GO:0097354)3.56679706
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.56445513
58regulation of dendritic spine morphogenesis (GO:0061001)3.52757820
59presynaptic membrane organization (GO:0097090)3.51447303
60regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48140233
61gamma-aminobutyric acid transport (GO:0015812)3.47883434
62positive regulation of neurotransmitter secretion (GO:0001956)3.47543691
63membrane depolarization (GO:0051899)3.47485108
64regulation of voltage-gated calcium channel activity (GO:1901385)3.44237972
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43118096
66fear response (GO:0042596)3.42933854
67C4-dicarboxylate transport (GO:0015740)3.42460607
68membrane depolarization during action potential (GO:0086010)3.40272195
69neurotransmitter transport (GO:0006836)3.39846365
70negative regulation of T cell receptor signaling pathway (GO:0050860)3.39556447
71regulation of synapse maturation (GO:0090128)3.39472056
72potassium ion import (GO:0010107)3.38843987
73transmission of nerve impulse (GO:0019226)3.36919511
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35906578
75regulation of synapse structural plasticity (GO:0051823)3.35092806
76retinal cone cell development (GO:0046549)3.33568866
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33056247
78cerebellar Purkinje cell differentiation (GO:0021702)3.32524837
79learning (GO:0007612)3.30944113
80neuron recognition (GO:0008038)3.30777715
81regulation of vesicle fusion (GO:0031338)3.27087535
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25721554
83regulation of neurotransmitter secretion (GO:0046928)3.25271243
84detection of calcium ion (GO:0005513)3.23871057
85cell communication by electrical coupling (GO:0010644)3.22274322
86cerebellar granule cell differentiation (GO:0021707)3.22241668
87negative regulation of Ras GTPase activity (GO:0034261)3.21532284
88positive regulation of neurotransmitter transport (GO:0051590)3.19961616
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.19834979
90regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.19641616
91amino acid import (GO:0043090)3.18008606
92proline transport (GO:0015824)3.16503473
93innervation (GO:0060384)3.13808123
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13321202
95synaptic transmission (GO:0007268)3.12970853
96neuromuscular process controlling posture (GO:0050884)3.12308865
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10975192
98regulation of synaptic transmission (GO:0050804)3.10664740
99chemosensory behavior (GO:0007635)3.10423125
100regulation of neurotransmitter levels (GO:0001505)3.10259212
101long term synaptic depression (GO:0060292)3.07594764
102dendritic spine morphogenesis (GO:0060997)3.06470227
103regulation of dendritic spine development (GO:0060998)3.05735238
104relaxation of cardiac muscle (GO:0055119)3.05627002
105startle response (GO:0001964)3.05508687
106sodium ion export (GO:0071436)3.04321980
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03750597
108regulation of cardiac muscle cell contraction (GO:0086004)3.03393468
109positive regulation of synaptic transmission (GO:0050806)3.03131920
110regulation of neurotransmitter transport (GO:0051588)3.01347667
111negative regulation of heart contraction (GO:0045822)2.99920090
112central nervous system myelination (GO:0022010)2.99169003
113axon ensheathment in central nervous system (GO:0032291)2.99169003
114regulation of inositol phosphate biosynthetic process (GO:0010919)2.98470195
115regulation of synaptic transmission, GABAergic (GO:0032228)2.97800196
116memory (GO:0007613)2.94736420
117righting reflex (GO:0060013)2.94192809
118cellular sodium ion homeostasis (GO:0006883)2.93941367
119regulation of neuron projection regeneration (GO:0070570)2.93267613
120regulation of axon regeneration (GO:0048679)2.93267613
121regulation of cell communication by electrical coupling (GO:0010649)2.93212625
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92966484
123protein localization to cilium (GO:0061512)2.91350377
124associative learning (GO:0008306)2.90748839
125neuronal ion channel clustering (GO:0045161)2.90547487
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90541142
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89808782
128negative regulation of heart rate (GO:0010459)2.89453910
129potassium ion homeostasis (GO:0055075)2.89104970
130synaptic vesicle transport (GO:0048489)2.88601119
131establishment of synaptic vesicle localization (GO:0097480)2.88601119
132synapse assembly (GO:0007416)2.88551678
133negative regulation of neurotransmitter transport (GO:0051589)2.86549079
134cell communication involved in cardiac conduction (GO:0086065)2.86501939
135acidic amino acid transport (GO:0015800)2.84913831
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.82704497
137regulation of cellular amide metabolic process (GO:0034248)2.79061745
138regulation of actin filament-based movement (GO:1903115)2.71900543
139regulation of platelet aggregation (GO:0090330)2.68216226
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68169252
141negative regulation of dendrite morphogenesis (GO:0050774)2.68039844
142regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67944790
143serotonin metabolic process (GO:0042428)2.67580607
144mechanosensory behavior (GO:0007638)2.64574876
145relaxation of smooth muscle (GO:0044557)2.64418503
146regulation of female receptivity (GO:0045924)2.62334060
147L-glutamate transport (GO:0015813)2.59814354
148relaxation of muscle (GO:0090075)2.58856724
149auditory behavior (GO:0031223)2.58759119
150regulation of calcium ion transmembrane transport (GO:1903169)2.52328923
151regulation of calcium ion transmembrane transporter activity (GO:1901019)2.52328923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.93991415
2GBX2_23144817_ChIP-Seq_PC3_Human4.57089174
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21291936
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15371735
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07206544
6GATA1_22025678_ChIP-Seq_K562_Human2.88004424
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.79233526
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75966904
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64247980
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.59268906
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56589257
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56589257
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56500107
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42970470
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40335761
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39673307
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39175366
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.35876294
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29956238
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.27999792
21DROSHA_22980978_ChIP-Seq_HELA_Human2.27634660
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17068670
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13084167
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.12981033
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12324823
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.07619729
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05505343
28TAF15_26573619_Chip-Seq_HEK293_Human2.01456745
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.97677166
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95759025
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.95500171
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93412010
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91677900
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91385520
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84597357
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81646960
37IGF1R_20145208_ChIP-Seq_DFB_Human1.79301947
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78697761
39P300_19829295_ChIP-Seq_ESCs_Human1.76862920
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75395316
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69249223
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69123545
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65045485
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62476612
45SCL_19346495_ChIP-Seq_HPC-7_Human1.58499450
46ZNF274_21170338_ChIP-Seq_K562_Hela1.57686113
47VDR_22108803_ChIP-Seq_LS180_Human1.55747383
48AR_25329375_ChIP-Seq_VCAP_Human1.55276085
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.49921468
50GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49737061
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47162049
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43055260
53* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40317448
54* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40317448
55FUS_26573619_Chip-Seq_HEK293_Human1.38264441
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37561113
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37399751
58AR_21572438_ChIP-Seq_LNCaP_Human1.37178064
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.35926062
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34986735
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33354376
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32975779
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32250857
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29684428
65* STAT3_23295773_ChIP-Seq_U87_Human1.29391765
66RUNX_20019798_ChIP-Seq_JUKART_Human1.27795116
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27368025
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.26550786
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26549177
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.25801280
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22293318
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.20533474
73* TCF4_23295773_ChIP-Seq_U87_Human1.20369360
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.18794593
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.18654743
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17812427
77TP53_16413492_ChIP-PET_HCT116_Human1.16911574
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.16188555
79HTT_18923047_ChIP-ChIP_STHdh_Human1.15620184
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14573046
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14529289
82RNF2_27304074_Chip-Seq_NSC_Mouse1.13924581
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13628855
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12794192
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.10236063
86ER_23166858_ChIP-Seq_MCF-7_Human1.09766559
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08646755
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08486646
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08142149
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.07936588
91JUN_21703547_ChIP-Seq_K562_Human1.06880320
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05955924
93* AR_19668381_ChIP-Seq_PC3_Human1.05944663
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.05657651
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05090701
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.04369180
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04000522
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03340453
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.02677539
100P53_22387025_ChIP-Seq_ESCs_Mouse1.02579917
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01619207
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.01291125
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.00980070
104* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99912627
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99311359
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99072341
107KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98990547
108KDM2B_26808549_Chip-Seq_REH_Human0.98417923
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.98145154
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98032708
111* TCF4_22108803_ChIP-Seq_LS180_Human0.97749976
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97116955
113* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96681622
114* SPI1_23127762_ChIP-Seq_K562_Human0.96654413
115* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96606891
116KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96479356
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96468471
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95930461
119* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95812659
120TP53_18474530_ChIP-ChIP_U2OS_Human0.95179268
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94619423
122CBP_20019798_ChIP-Seq_JUKART_Human0.93566763
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93566763
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93229728
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.93206158
126BCAT_22108803_ChIP-Seq_LS180_Human0.92199943
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.89856348
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.89829324
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88715918
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.88388892
131* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88320478
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87062382
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86569847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.45104384
2MP0003880_abnormal_central_pattern5.16466007
3MP0003635_abnormal_synaptic_transmissio4.11825666
4MP0009745_abnormal_behavioral_response3.60669932
5MP0001968_abnormal_touch/_nociception3.55624438
6MP0002063_abnormal_learning/memory/cond3.22524250
7MP0003303_peritoneal_inflammation3.21531337
8MP0004270_analgesia3.19463976
9MP0009046_muscle_twitch3.17426369
10MP0002736_abnormal_nociception_after3.16588292
11MP0002735_abnormal_chemical_nociception3.14729422
12MP0002064_seizures3.14086612
13MP0002572_abnormal_emotion/affect_behav2.81671868
14MP0002272_abnormal_nervous_system2.81070288
15MP0001501_abnormal_sleep_pattern2.66640614
16MP0001188_hyperpigmentation2.43331348
17MP0002734_abnormal_mechanical_nocicepti2.40898073
18MP0002822_catalepsy2.28197835
19MP0001440_abnormal_grooming_behavior2.19977948
20MP0001486_abnormal_startle_reflex2.19485575
21MP0002067_abnormal_sensory_capabilities2.15438931
22MP0006276_abnormal_autonomic_nervous2.04487934
23MP0005464_abnormal_platelet_physiology2.04406315
24MP0003787_abnormal_imprinting2.04250911
25MP0008569_lethality_at_weaning2.04013437
26MP0005423_abnormal_somatic_nervous1.99746148
27MP0001970_abnormal_pain_threshold1.97948850
28MP0003690_abnormal_glial_cell1.90969846
29MP0002733_abnormal_thermal_nociception1.86934847
30MP0003879_abnormal_hair_cell1.81996154
31MP0002184_abnormal_innervation1.79507943
32MP0005646_abnormal_pituitary_gland1.65589950
33MP0004084_abnormal_cardiac_muscle1.64782113
34MP0002557_abnormal_social/conspecific_i1.60442941
35MP0000920_abnormal_myelination1.59607744
36MP0004924_abnormal_behavior1.55639436
37MP0005386_behavior/neurological_phenoty1.55639436
38MP0005645_abnormal_hypothalamus_physiol1.48733852
39MP0004811_abnormal_neuron_physiology1.46836877
40MP0001984_abnormal_olfaction1.45383280
41MP0006082_CNS_inflammation1.44827821
42MP0004858_abnormal_nervous_system1.42940065
43MP0005409_darkened_coat_color1.42865461
44MP0000566_synostosis1.41061186
45MP0003329_amyloid_beta_deposits1.40417437
46MP0004036_abnormal_muscle_relaxation1.38823810
47MP0010386_abnormal_urinary_bladder1.35679316
48MP0002909_abnormal_adrenal_gland1.32245848
49MP0004142_abnormal_muscle_tone1.31959766
50MP0002876_abnormal_thyroid_physiology1.30782150
51MP0001502_abnormal_circadian_rhythm1.29758856
52MP0001905_abnormal_dopamine_level1.29578439
53MP0000955_abnormal_spinal_cord1.28441749
54MP0002066_abnormal_motor_capabilities/c1.26868854
55MP0004130_abnormal_muscle_cell1.25775527
56MP0006292_abnormal_olfactory_placode1.25769843
57MP0003045_fibrosis1.25194073
58MP0001529_abnormal_vocalization1.22740407
59MP0008004_abnormal_stomach_pH1.22185238
60MP0000778_abnormal_nervous_system1.21739379
61MP0002882_abnormal_neuron_morphology1.17133260
62MP0004145_abnormal_muscle_electrophysio1.16555569
63MP0003633_abnormal_nervous_system1.16437954
64MP0005167_abnormal_blood-brain_barrier1.16368040
65MP0001986_abnormal_taste_sensitivity1.16008773
66MP0009780_abnormal_chondrocyte_physiolo1.12168081
67MP0004510_myositis1.10391993
68MP0000015_abnormal_ear_pigmentation1.09191737
69MP0005253_abnormal_eye_physiology1.07492645
70MP0002837_dystrophic_cardiac_calcinosis1.03450227
71MP0005174_abnormal_tail_pigmentation1.03072989
72MP0002638_abnormal_pupillary_reflex0.97182821
73MP0003631_nervous_system_phenotype0.96925753
74MP0008874_decreased_physiological_sensi0.96050036
75MP0004742_abnormal_vestibular_system0.95881178
76MP0005551_abnormal_eye_electrophysiolog0.93511672
77MP0008872_abnormal_physiological_respon0.92425982
78MP0003122_maternal_imprinting0.92123668
79MP0003646_muscle_fatigue0.92047054
80MP0002229_neurodegeneration0.89914705
81MP0003724_increased_susceptibility_to0.89365901
82MP0001963_abnormal_hearing_physiology0.87458409
83MP0001664_abnormal_digestion0.86841608
84MP0005535_abnormal_body_temperature0.86576852
85MP0001545_abnormal_hematopoietic_system0.85733541
86MP0005397_hematopoietic_system_phenotyp0.85733541
87MP0004484_altered_response_of0.85558543
88MP0003137_abnormal_impulse_conducting0.85071441
89MP0003183_abnormal_peptide_metabolism0.84105735
90MP0004885_abnormal_endolymph0.83223400
91MP0003075_altered_response_to0.81765062
92MP0002069_abnormal_eating/drinking_beha0.80748972
93MP0005166_decreased_susceptibility_to0.80014417
94MP0000383_abnormal_hair_follicle0.79879073
95MP0002152_abnormal_brain_morphology0.79724698
96MP0009379_abnormal_foot_pigmentation0.79314159
97MP0005171_absent_coat_pigmentation0.78594492
98MP0000230_abnormal_systemic_arterial0.76127919
99MP0004147_increased_porphyrin_level0.75333515
100MP0004215_abnormal_myocardial_fiber0.74970531
101MP0008877_abnormal_DNA_methylation0.72324387
102MP0001765_abnormal_ion_homeostasis0.71037554
103MP0000569_abnormal_digit_pigmentation0.69656589
104MP0001835_abnormal_antigen_presentation0.69431498
105MP0003136_yellow_coat_color0.69100342
106MP0000681_abnormal_thyroid_gland0.68563726
107MP0000343_altered_response_to0.67917189
108MP0004043_abnormal_pH_regulation0.65403049
109MP0005620_abnormal_muscle_contractility0.65051761
110MP0004085_abnormal_heartbeat0.64865336
111MP0003638_abnormal_response/metabolism_0.64807582
112MP0002972_abnormal_cardiac_muscle0.64217464
113MP0000749_muscle_degeneration0.63787202
114MP0005394_taste/olfaction_phenotype0.63380056
115MP0005499_abnormal_olfactory_system0.63380056
116MP0001485_abnormal_pinna_reflex0.62809427
117MP0003632_abnormal_nervous_system0.61787004
118MP0002095_abnormal_skin_pigmentation0.61721171
119MP0005671_abnormal_response_to0.61385556
120MP0003656_abnormal_erythrocyte_physiolo0.61036447
121MP0002752_abnormal_somatic_nervous0.60084181
122MP0000751_myopathy0.59246599
123MP0000604_amyloidosis0.58505533
124MP0000631_abnormal_neuroendocrine_gland0.58449695
125MP0000013_abnormal_adipose_tissue0.55656310
126MP0005595_abnormal_vascular_smooth0.54051133
127MP0003172_abnormal_lysosome_physiology0.51975628
128MP0001177_atelectasis0.51426056
129MP0002234_abnormal_pharynx_morphology0.50230686
130MP0000026_abnormal_inner_ear0.49412032

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.18331824
2Visual hallucinations (HP:0002367)5.90068349
3Myokymia (HP:0002411)5.84012840
4Focal seizures (HP:0007359)5.76970388
5Febrile seizures (HP:0002373)5.66382509
6Atonic seizures (HP:0010819)5.32875790
7Epileptic encephalopathy (HP:0200134)5.15711492
8Progressive cerebellar ataxia (HP:0002073)5.14548853
9Absence seizures (HP:0002121)4.87339109
10Dialeptic seizures (HP:0011146)4.51130660
11Gaze-evoked nystagmus (HP:0000640)4.38181465
12Hyperventilation (HP:0002883)4.13999604
13Generalized tonic-clonic seizures (HP:0002069)3.94647529
14Action tremor (HP:0002345)3.80476761
15Broad-based gait (HP:0002136)3.77956186
16Prolonged bleeding time (HP:0003010)3.75157322
17Truncal ataxia (HP:0002078)3.35986963
18Dysdiadochokinesis (HP:0002075)3.21210073
19Sudden death (HP:0001699)3.19376246
20Impaired smooth pursuit (HP:0007772)3.17523602
21Diplopia (HP:0000651)3.13029431
22Abnormality of binocular vision (HP:0011514)3.13029431
23Dysmetria (HP:0001310)3.11411848
24Progressive inability to walk (HP:0002505)3.09893575
25Depression (HP:0000716)3.06803058
26Purpura (HP:0000979)3.06464032
27Anxiety (HP:0000739)3.03499476
28Bundle branch block (HP:0011710)2.99274839
29Amblyopia (HP:0000646)2.98336960
30Menorrhagia (HP:0000132)2.92026204
31Scanning speech (HP:0002168)2.90923907
32Poor eye contact (HP:0000817)2.88434353
33Petechiae (HP:0000967)2.82562134
34Abnormality of ocular smooth pursuit (HP:0000617)2.81957129
35Supranuclear gaze palsy (HP:0000605)2.78099358
36Epistaxis (HP:0000421)2.71285657
37Absent speech (HP:0001344)2.70670974
38Drooling (HP:0002307)2.61397126
39Excessive salivation (HP:0003781)2.61397126
40Hemiparesis (HP:0001269)2.59916621
41Protruding tongue (HP:0010808)2.56180730
42Impaired vibration sensation in the lower limbs (HP:0002166)2.55929766
43Inability to walk (HP:0002540)2.54111661
44Abnormal eating behavior (HP:0100738)2.54046502
45Epileptiform EEG discharges (HP:0011182)2.51346074
46Gingival bleeding (HP:0000225)2.51237490
47Genetic anticipation (HP:0003743)2.50305629
48Menstrual irregularities (HP:0000858)2.49505346
49Syncope (HP:0001279)2.47865727
50Impaired social interactions (HP:0000735)2.47810497
51Abnormal social behavior (HP:0012433)2.47810497
52Abnormal hair whorl (HP:0010721)2.45070604
53Tetraplegia (HP:0002445)2.44426621
54Decreased central vision (HP:0007663)2.39672987
55Large for gestational age (HP:0001520)2.39171180
56Postural instability (HP:0002172)2.37950228
57Bradykinesia (HP:0002067)2.36326360
58Hypothermia (HP:0002045)2.36096825
59Abnormal auditory evoked potentials (HP:0006958)2.35869556
60Papilledema (HP:0001085)2.35069850
61Mutism (HP:0002300)2.33866923
62Dysmetric saccades (HP:0000641)2.31140084
63Horizontal nystagmus (HP:0000666)2.31087265
64Hemiplegia (HP:0002301)2.28797355
65Stereotypic behavior (HP:0000733)2.26247978
66Limb ataxia (HP:0002070)2.24807627
67Status epilepticus (HP:0002133)2.23578946
68Psychosis (HP:0000709)2.21425269
69EEG with generalized epileptiform discharges (HP:0011198)2.19917651
70Postural tremor (HP:0002174)2.19420467
71Increased mean platelet volume (HP:0011877)2.18929572
72Generalized hypopigmentation of hair (HP:0011358)2.18084682
73Abnormal platelet volume (HP:0011876)2.17310953
74Ankle clonus (HP:0011448)2.17261349
75Spastic gait (HP:0002064)2.15701457
76Autoamputation (HP:0001218)2.14705902
77Decreased circulating renin level (HP:0003351)2.14692543
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14159943
79Conjunctival telangiectasia (HP:0000524)2.11288577
80Fair hair (HP:0002286)2.09877185
81Increased circulating renin level (HP:0000848)2.09438264
82Atrial fibrillation (HP:0005110)2.09170906
83Retinal dysplasia (HP:0007973)2.08574845
84Urinary bladder sphincter dysfunction (HP:0002839)2.07693754
85Gait imbalance (HP:0002141)2.06754748
86Fetal akinesia sequence (HP:0001989)2.06726791
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06657361
88Hyperlipoproteinemia (HP:0010980)2.05790600
89Vertigo (HP:0002321)2.03895111
90Peripheral hypomyelination (HP:0007182)2.02274150
91Amyotrophic lateral sclerosis (HP:0007354)2.01540254
92Agitation (HP:0000713)2.01241742
93Increased cerebral lipofuscin (HP:0011813)1.99362943
94Gait ataxia (HP:0002066)1.98790626
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.98380034
96Cerebral hypomyelination (HP:0006808)1.97040297
97Blue irides (HP:0000635)1.96300746
98Heart block (HP:0012722)1.96203400
99Primary atrial arrhythmia (HP:0001692)1.95907530
100Generalized myoclonic seizures (HP:0002123)1.94862367
101Impaired vibratory sensation (HP:0002495)1.94860913
102Intention tremor (HP:0002080)1.94166247
103Delusions (HP:0000746)1.94011039
104Congenital primary aphakia (HP:0007707)1.92994604
105Nonprogressive disorder (HP:0003680)1.91817393
106Medial flaring of the eyebrow (HP:0010747)1.91765352
107Nephrogenic diabetes insipidus (HP:0009806)1.91511161
108Hyporeflexia of lower limbs (HP:0002600)1.89635295
109Hypsarrhythmia (HP:0002521)1.89460426
110Acute lymphatic leukemia (HP:0006721)1.88854175
111Esotropia (HP:0000565)1.85697060
112Type II lissencephaly (HP:0007260)1.83449026
113Abnormality of salivation (HP:0100755)1.83116119
114Memory impairment (HP:0002354)1.82849096
115Supraventricular tachycardia (HP:0004755)1.82639518
116Spinal canal stenosis (HP:0003416)1.82499791
117Iris hypopigmentation (HP:0007730)1.82336829
118Cortical visual impairment (HP:0100704)1.80860659
119Unsteady gait (HP:0002317)1.80334138
120Widely spaced teeth (HP:0000687)1.80210085
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79608487
122Polyphagia (HP:0002591)1.78176769
123Abnormality of saccadic eye movements (HP:0000570)1.76194284
124Incomplete penetrance (HP:0003829)1.76113916
125Bradycardia (HP:0001662)1.75585893
126Ventricular arrhythmia (HP:0004308)1.74947945
127Muscle fiber splitting (HP:0003555)1.74700826
128Abnormal EKG (HP:0003115)1.74600074
129Torticollis (HP:0000473)1.74360984
130Hypokalemic alkalosis (HP:0001949)1.73852156
131Supraventricular arrhythmia (HP:0005115)1.73665266
132Neurofibrillary tangles (HP:0002185)1.72643236
133Ocular albinism (HP:0001107)1.72530387
134Abnormality of the lower motor neuron (HP:0002366)1.72430592
135Cerebral inclusion bodies (HP:0100314)1.71004641
136Inappropriate behavior (HP:0000719)1.70958087
137Decreased lacrimation (HP:0000633)1.70774589
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.70749062
139Absent/shortened dynein arms (HP:0200106)1.70749062
140Thyroid-stimulating hormone excess (HP:0002925)1.70399616
141Annular pancreas (HP:0001734)1.68787010
142Lower limb muscle weakness (HP:0007340)1.68223386
143Thickened helices (HP:0000391)1.66809612
144Focal dystonia (HP:0004373)1.66650720
145Dysautonomia (HP:0002459)1.66286132
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65955162
147Ventricular fibrillation (HP:0001663)1.65632438
148Macroglossia (HP:0000158)1.65176269
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65003652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.30642574
2NTRK35.37381898
3EPHA44.08126014
4RIPK43.88105878
5MKNK13.16043497
6TNIK3.07754800
7MAP2K73.04461672
8FRK3.02141891
9MAP3K123.02109363
10CASK2.84163336
11MAP3K92.81349417
12MAP3K42.67824136
13TAOK12.62178177
14MINK12.56813009
15PRPF4B2.55478754
16FES2.20987128
17MAP2K32.16400106
18MAP3K112.08776220
19ARAF1.96683062
20MAP3K31.92864373
21DAPK11.88206830
22CAMKK21.87364532
23MAP3K131.82574310
24PLK21.80016455
25DAPK21.75019311
26MAP2K41.71163677
27KSR21.66036239
28GRK51.59938464
29CDK191.57376201
30MAP4K21.54653042
31JAK31.50049138
32CAMKK11.48022864
33BMPR21.47546448
34MUSK1.44633311
35PTK2B1.43557531
36NTRK11.38083397
37KSR11.35335361
38NTRK21.33725288
39NME11.33296207
40SIK21.30299459
41MYLK1.27894255
42CAMK11.25747081
43PRKCG1.25731914
44STK381.25615641
45CAMK2A1.24231830
46CDK51.23129715
47CAMK2B1.21730806
48MAPK131.18862963
49MAP3K51.18452522
50PDK21.14821126
51SIK31.13457056
52PNCK1.11870784
53STK161.10347962
54BLK1.08739675
55MARK11.08653597
56STK38L1.08367895
57PAK61.07503921
58PKN11.06672084
59RAF11.01463401
60PIK3CG0.97867285
61PAK30.97296885
62MAPK120.96969983
63TEC0.93370968
64TNK20.92987580
65TAOK30.89947785
66SGK20.86142550
67MAP3K20.84780901
68ABL20.83600527
69PHKG20.78553318
70PHKG10.78553318
71PINK10.78169413
72FGR0.77313235
73CAMK2D0.75594297
74DYRK1A0.74460403
75PRKD30.73529993
76TXK0.70953432
77FER0.70682893
78SGK2230.69851270
79SGK4940.69851270
80MAP3K10.67888018
81PRKCQ0.64460219
82ITK0.63992831
83GRK70.63627121
84TAOK20.63189397
85BTK0.62582448
86SGK10.62522384
87PRKCE0.60834613
88BRAF0.59323090
89SYK0.59062060
90CDK180.58741964
91CAMK2G0.58642117
92CDK140.57770512
93PIK3CA0.57292912
94AKT30.56857798
95MATK0.54954053
96GRK60.54520429
97CDK150.54151283
98WNK10.52889545
99JAK20.52106224
100MAPK70.51511108
101JAK10.49979001
102CAMK40.49185688
103OXSR10.48911589
104ADRBK20.48645913
105CDK11A0.48605681
106PDK10.48261861
107LYN0.46974178
108STK110.46344010
109CCNB10.45945894
110SGK30.45301224
111HCK0.45003445
112BMX0.43620819
113PRKD20.43575242
114CSF1R0.41827921
115PRKD10.41618180
116FYN0.41319398
117NEK60.40261583
118UHMK10.39964405
119ZAP700.38212841
120PRKG10.37324854
121PDPK10.37178958
122MAP3K60.37130045
123INSRR0.36635626
124ROCK10.36604238
125PRKACG0.35963762
126PRKACA0.35004076
127PRKCA0.33932561
128PRKCH0.33593474
129CDK30.32590764
130RPS6KA30.32123955
131LMTK20.29776290
132MAPK100.29107509
133CSNK1G20.26849588
134PRKCB0.26497274
135MOS0.26307160
136MAP3K70.24674013
137RET0.24299705
138KIT0.23727651
139MAP2K10.22666697
140MARK20.22624261
141PRKCZ0.22378680
142YES10.21100118

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.60814498
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16234022
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.10826236
4Long-term potentiation_Homo sapiens_hsa047203.10455496
5Circadian entrainment_Homo sapiens_hsa047132.87137872
6Glutamatergic synapse_Homo sapiens_hsa047242.81564515
7Morphine addiction_Homo sapiens_hsa050322.67073721
8GABAergic synapse_Homo sapiens_hsa047272.66729414
9Amphetamine addiction_Homo sapiens_hsa050312.56986197
10Olfactory transduction_Homo sapiens_hsa047402.51074195
11Salivary secretion_Homo sapiens_hsa049702.36919644
12Taste transduction_Homo sapiens_hsa047422.28514193
13Long-term depression_Homo sapiens_hsa047302.14221984
14Dopaminergic synapse_Homo sapiens_hsa047282.08742386
15Collecting duct acid secretion_Homo sapiens_hsa049662.07906215
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01525303
17Insulin secretion_Homo sapiens_hsa049111.97617345
18Calcium signaling pathway_Homo sapiens_hsa040201.91395293
19Serotonergic synapse_Homo sapiens_hsa047261.87967451
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87488556
21Cholinergic synapse_Homo sapiens_hsa047251.80432626
22Gastric acid secretion_Homo sapiens_hsa049711.76858558
23Renin secretion_Homo sapiens_hsa049241.74047681
24Nitrogen metabolism_Homo sapiens_hsa009101.73216228
25Oxytocin signaling pathway_Homo sapiens_hsa049211.62722231
26beta-Alanine metabolism_Homo sapiens_hsa004101.51208527
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45026664
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38987439
29GnRH signaling pathway_Homo sapiens_hsa049121.36349508
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34353127
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32689744
32* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30252557
33cAMP signaling pathway_Homo sapiens_hsa040241.28904743
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27864391
35Cocaine addiction_Homo sapiens_hsa050301.27536414
36Vibrio cholerae infection_Homo sapiens_hsa051101.22728545
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22041119
38Histidine metabolism_Homo sapiens_hsa003401.12849796
39Gap junction_Homo sapiens_hsa045401.07612545
40ABC transporters_Homo sapiens_hsa020101.07515932
41Pancreatic secretion_Homo sapiens_hsa049721.04786570
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04285743
43Alzheimers disease_Homo sapiens_hsa050100.98778339
44Type II diabetes mellitus_Homo sapiens_hsa049300.98632583
45Cardiac muscle contraction_Homo sapiens_hsa042600.97997980
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97770345
47Estrogen signaling pathway_Homo sapiens_hsa049150.95539217
48Oxidative phosphorylation_Homo sapiens_hsa001900.92789000
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.91226266
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91155395
51Melanogenesis_Homo sapiens_hsa049160.90657685
52Glioma_Homo sapiens_hsa052140.87434357
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87356895
54African trypanosomiasis_Homo sapiens_hsa051430.85670489
55Thyroid hormone synthesis_Homo sapiens_hsa049180.84213472
56Bile secretion_Homo sapiens_hsa049760.82452780
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81719353
58Butanoate metabolism_Homo sapiens_hsa006500.80170445
59Phototransduction_Homo sapiens_hsa047440.78789096
60Type I diabetes mellitus_Homo sapiens_hsa049400.76997842
61ErbB signaling pathway_Homo sapiens_hsa040120.73039263
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72592416
63Rheumatoid arthritis_Homo sapiens_hsa053230.70263780
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70128682
65Inositol phosphate metabolism_Homo sapiens_hsa005620.68494520
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67121346
67* Phospholipase D signaling pathway_Homo sapiens_hsa040720.66542949
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65862175
69Axon guidance_Homo sapiens_hsa043600.65726701
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64900060
71Circadian rhythm_Homo sapiens_hsa047100.64506496
72Oocyte meiosis_Homo sapiens_hsa041140.63910493
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63609776
74Tryptophan metabolism_Homo sapiens_hsa003800.62969563
75* Choline metabolism in cancer_Homo sapiens_hsa052310.61230422
76Fatty acid biosynthesis_Homo sapiens_hsa000610.59368087
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57607858
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56561537
79* Glycerophospholipid metabolism_Homo sapiens_hsa005640.55946955
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55785291
81VEGF signaling pathway_Homo sapiens_hsa043700.54707542
82* Glycerolipid metabolism_Homo sapiens_hsa005610.53616721
83Glucagon signaling pathway_Homo sapiens_hsa049220.53582385
84Lysine degradation_Homo sapiens_hsa003100.53402488
85MAPK signaling pathway_Homo sapiens_hsa040100.53077982
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52531202
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51583073
88Ovarian steroidogenesis_Homo sapiens_hsa049130.48495342
89Ras signaling pathway_Homo sapiens_hsa040140.46846844
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45152485
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.44303080
92Amoebiasis_Homo sapiens_hsa051460.42889442
93Rap1 signaling pathway_Homo sapiens_hsa040150.42803565
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42493158
95Dorso-ventral axis formation_Homo sapiens_hsa043200.41865402
96Fatty acid elongation_Homo sapiens_hsa000620.41459401
97Parkinsons disease_Homo sapiens_hsa050120.40914024
98Fatty acid metabolism_Homo sapiens_hsa012120.40132640
99Huntingtons disease_Homo sapiens_hsa050160.40131235
100Fatty acid degradation_Homo sapiens_hsa000710.38260804
101Dilated cardiomyopathy_Homo sapiens_hsa054140.38188763
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.38133698
103Chemokine signaling pathway_Homo sapiens_hsa040620.37975345
104Alcoholism_Homo sapiens_hsa050340.36537098
105Tuberculosis_Homo sapiens_hsa051520.36107478
106Osteoclast differentiation_Homo sapiens_hsa043800.35412180
107Staphylococcus aureus infection_Homo sapiens_hsa051500.34521180
108Mineral absorption_Homo sapiens_hsa049780.31886954
109Hematopoietic cell lineage_Homo sapiens_hsa046400.30512490
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28958193
111Phagosome_Homo sapiens_hsa041450.28381702
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28316841
113Ether lipid metabolism_Homo sapiens_hsa005650.28137413
114Non-small cell lung cancer_Homo sapiens_hsa052230.26779605
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26777324
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26115451
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26028272
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24446395
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23294748
120Wnt signaling pathway_Homo sapiens_hsa043100.23124357
121Platelet activation_Homo sapiens_hsa046110.22402421
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22196717
123Salmonella infection_Homo sapiens_hsa051320.21610608
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20311546
125Endocytosis_Homo sapiens_hsa041440.19703918
126B cell receptor signaling pathway_Homo sapiens_hsa046620.17109423

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