DGKH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.77809989
2detection of temperature stimulus involved in sensory perception (GO:0050961)5.77809989
3negative regulation of dendrite morphogenesis (GO:0050774)5.51500347
4detection of temperature stimulus (GO:0016048)5.34918081
5membrane depolarization during action potential (GO:0086010)5.16231968
6neuronal action potential (GO:0019228)4.86702443
7urinary tract smooth muscle contraction (GO:0014848)4.84158189
8regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.52322963
9cilium or flagellum-dependent cell motility (GO:0001539)4.50750002
10glutamate secretion (GO:0014047)4.29836732
11acrosome reaction (GO:0007340)4.28387343
12neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.24394909
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18196298
14positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.17928589
15cell migration in hindbrain (GO:0021535)4.12681923
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12397113
17peripheral nervous system neuron development (GO:0048935)4.05290218
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01358077
19negative regulation of dendrite development (GO:2000171)3.96500717
20calcium ion-dependent exocytosis (GO:0017156)3.94729858
21proline transport (GO:0015824)3.92879985
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84957554
23regulation of pigment cell differentiation (GO:0050932)3.83095438
24adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.78054709
25protein localization to synapse (GO:0035418)3.75268336
26response to pain (GO:0048265)3.74567191
27negative regulation of calcium ion transport into cytosol (GO:0010523)3.62682016
28interkinetic nuclear migration (GO:0022027)3.60637476
29regulation of synaptic vesicle exocytosis (GO:2000300)3.59010558
30negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55144380
31negative regulation of systemic arterial blood pressure (GO:0003085)3.53458608
32synaptic vesicle maturation (GO:0016188)3.51668859
33inositol phosphate-mediated signaling (GO:0048016)3.51376644
34synaptic vesicle exocytosis (GO:0016079)3.46927745
35cilium movement (GO:0003341)3.44566487
36regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40946972
37positive regulation of developmental pigmentation (GO:0048087)3.40576796
38behavioral response to pain (GO:0048266)3.39233883
39positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38319852
40membrane depolarization (GO:0051899)3.35855704
41relaxation of cardiac muscle (GO:0055119)3.34648580
42neuronal action potential propagation (GO:0019227)3.33382392
43monoubiquitinated protein deubiquitination (GO:0035520)3.32737721
44pericardium development (GO:0060039)3.32434179
45neuromuscular synaptic transmission (GO:0007274)3.31626432
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31201136
47positive regulation of muscle hypertrophy (GO:0014742)3.31138863
48positive regulation of cardiac muscle hypertrophy (GO:0010613)3.31138863
49regulation of glutamate receptor signaling pathway (GO:1900449)3.27952890
50dopamine receptor signaling pathway (GO:0007212)3.26600768
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25846126
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.25463288
53nerve growth factor signaling pathway (GO:0038180)3.24964101
54regulation of synaptic vesicle transport (GO:1902803)3.21090354
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.19068746
56motile cilium assembly (GO:0044458)3.17012076
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.16474861
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14082606
59vocalization behavior (GO:0071625)3.12586700
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11938378
61synaptic transmission, glutamatergic (GO:0035249)3.11728425
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10358597
63phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.09290265
64retina layer formation (GO:0010842)3.08844403
65vesicle transport along microtubule (GO:0047496)3.08453734
66cytoplasmic mRNA processing body assembly (GO:0033962)3.07351860
67axonemal dynein complex assembly (GO:0070286)3.07167541
68glutamate receptor signaling pathway (GO:0007215)3.06166229
69neuron cell-cell adhesion (GO:0007158)3.05135968
70lipid translocation (GO:0034204)3.04557216
71phospholipid translocation (GO:0045332)3.04557216
72sympathetic nervous system development (GO:0048485)3.03956897
73sperm motility (GO:0030317)3.03872300
74cerebellar Purkinje cell differentiation (GO:0021702)3.03611034
75positive regulation of potassium ion transmembrane transport (GO:1901381)3.03059773
76acrosome assembly (GO:0001675)3.02984558
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.00391577
78behavioral response to ethanol (GO:0048149)3.00362376
79establishment of protein localization to Golgi (GO:0072600)2.99622080
80behavioral response to nicotine (GO:0035095)2.99483982
81neuron-neuron synaptic transmission (GO:0007270)2.97948487
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97374030
83innervation (GO:0060384)2.95811876
84cell communication involved in cardiac conduction (GO:0086065)2.95344900
85regulation of hippo signaling (GO:0035330)2.94988453
86locomotory exploration behavior (GO:0035641)2.94141740
87action potential (GO:0001508)2.93317559
88neurofilament cytoskeleton organization (GO:0060052)2.92444461
89positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.89246480
90regulation of establishment of cell polarity (GO:2000114)2.88795052
91chemosensory behavior (GO:0007635)2.88153626
92snRNA transcription (GO:0009301)2.86399084
93nucleus localization (GO:0051647)2.85499641
94multicellular organismal movement (GO:0050879)2.85172099
95musculoskeletal movement (GO:0050881)2.85172099
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.84672871
97response to water (GO:0009415)2.83162833
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83115524
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82810544
100presynaptic membrane assembly (GO:0097105)2.82414113
101peristalsis (GO:0030432)2.81139252
102cellular response to ethanol (GO:0071361)2.81056798
103regulation of neurotransmitter secretion (GO:0046928)2.80847868
104detection of calcium ion (GO:0005513)2.80426892
105detection of mechanical stimulus involved in sensory perception (GO:0050974)2.80265140
106activation of adenylate cyclase activity (GO:0007190)2.79794530
107regulation of postsynaptic membrane potential (GO:0060078)2.79086076
108multicellular organismal response to stress (GO:0033555)2.77991441
109epithelial cilium movement (GO:0003351)2.77459267
110smooth muscle tissue development (GO:0048745)2.77373528
111regulation of neuronal synaptic plasticity (GO:0048168)2.76086542
112negative regulation of complement activation (GO:0045916)2.74937619
113fusion of sperm to egg plasma membrane (GO:0007342)2.74773451
114cellular potassium ion homeostasis (GO:0030007)2.73621447
115retinal cone cell development (GO:0046549)2.72783354
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.72312352
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71745528
118primary amino compound metabolic process (GO:1901160)2.70976011
119activation of protein kinase A activity (GO:0034199)2.70925597
120regulation of protein kinase A signaling (GO:0010738)2.70884957
121plasma membrane fusion (GO:0045026)2.70557491
122regulation of establishment or maintenance of cell polarity (GO:0032878)2.70193230
123protein polyglutamylation (GO:0018095)2.69930564
124protein localization to cilium (GO:0061512)2.69926486
125exploration behavior (GO:0035640)2.69360871
126neurotransmitter secretion (GO:0007269)2.68581457
127cellular response to ATP (GO:0071318)2.68237670
128organelle transport along microtubule (GO:0072384)2.67719795
129negative regulation of homotypic cell-cell adhesion (GO:0034111)2.66910934
130lymphangiogenesis (GO:0001946)2.65163001
131positive regulation of fibroblast migration (GO:0010763)2.64613184
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.64534904
133positive regulation of adenylate cyclase activity (GO:0045762)2.62819899
134UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62316739
135negative regulation of microtubule polymerization (GO:0031115)2.61589454
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60706269
137phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.57297030
138protein K48-linked deubiquitination (GO:0071108)2.57044460
139positive regulation of phosphatase activity (GO:0010922)2.56859298
140negative regulation of translation, ncRNA-mediated (GO:0040033)2.56106251
141regulation of translation, ncRNA-mediated (GO:0045974)2.56106251
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56106251
143auditory receptor cell differentiation (GO:0042491)2.54769233
144metanephric nephron tubule development (GO:0072234)2.50855438
145metanephric tubule development (GO:0072170)2.50855438
146axoneme assembly (GO:0035082)2.48843685
147renal tubule morphogenesis (GO:0061333)2.48713485
148glucocorticoid receptor signaling pathway (GO:0042921)2.45896523
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45387698
150prenylation (GO:0097354)2.44748374
151protein prenylation (GO:0018342)2.44748374
152positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42771490
153regulation of alkaline phosphatase activity (GO:0010692)2.42761935
154regulation of centriole replication (GO:0046599)2.42435833
155Golgi to endosome transport (GO:0006895)2.38715178
156negative regulation of keratinocyte proliferation (GO:0010839)2.37881925
157embryonic foregut morphogenesis (GO:0048617)2.37763296
158metanephric nephron epithelium development (GO:0072243)2.37610791
159cilium organization (GO:0044782)2.37318250
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34324867
161relaxation of muscle (GO:0090075)2.33513800
162cilium assembly (GO:0042384)2.33386195
163negative regulation of fatty acid transport (GO:2000192)2.32288824
164intestinal epithelial cell development (GO:0060576)2.31779079
165left/right axis specification (GO:0070986)2.31043777
166regulation of cardiac muscle hypertrophy (GO:0010611)2.30624036
167ovulation from ovarian follicle (GO:0001542)2.30463225
168early endosome to late endosome transport (GO:0045022)2.30258230
169regulation of sarcomere organization (GO:0060297)2.29723904
170protein K11-linked deubiquitination (GO:0035871)2.27276770
171atrial cardiac muscle cell action potential (GO:0086014)2.26529570
172protein targeting to lysosome (GO:0006622)2.25270309
173establishment of protein localization to vacuole (GO:0072666)2.25270309
174protein targeting to vacuole (GO:0006623)2.25270309
175positive regulation of cation channel activity (GO:2001259)2.24580954
176protein targeting to Golgi (GO:0000042)2.24260115
177replicative senescence (GO:0090399)2.24215772
178keratinocyte proliferation (GO:0043616)2.24096941
179cell morphogenesis involved in neuron differentiation (GO:0048667)2.23884913
180cGMP metabolic process (GO:0046068)2.23759725
181positive regulation of cardiac muscle cell differentiation (GO:2000727)2.23608737
182regulation of protein polyubiquitination (GO:1902914)2.23461689
183protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.23149140
184serotonin metabolic process (GO:0042428)2.21587140
185artery development (GO:0060840)2.21478467
186histone H3-K4 trimethylation (GO:0080182)2.20518267
187striated muscle atrophy (GO:0014891)2.20385246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15371017
2GBX2_23144817_ChIP-Seq_PC3_Human3.84362231
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.79072501
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54242079
5VDR_22108803_ChIP-Seq_LS180_Human2.43305678
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33941050
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32954527
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24101224
9REST_21632747_ChIP-Seq_MESCs_Mouse2.23888537
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23836936
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.12937725
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11045178
13TAF15_26573619_Chip-Seq_HEK293_Human2.11018721
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08161883
15SMAD4_21799915_ChIP-Seq_A2780_Human2.08033065
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06325725
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98758710
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98064762
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97715190
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96652163
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96275237
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93158226
23TP53_16413492_ChIP-PET_HCT116_Human1.93150870
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89270635
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89270635
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.87617195
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83997653
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.82496424
29P300_19829295_ChIP-Seq_ESCs_Human1.79042951
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.78837863
31EWS_26573619_Chip-Seq_HEK293_Human1.73377792
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69629747
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68818064
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68084032
35ER_23166858_ChIP-Seq_MCF-7_Human1.66697656
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66165769
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62982729
38DROSHA_22980978_ChIP-Seq_HELA_Human1.61761253
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.61561285
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60501289
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60225673
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.58352166
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57922102
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56470096
45* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56084587
46* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54530157
47STAT3_23295773_ChIP-Seq_U87_Human1.54106013
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53724210
49* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53093423
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.52305220
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52265750
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.51509635
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50959452
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50068212
55AR_25329375_ChIP-Seq_VCAP_Human1.48628206
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47610049
57AHR_22903824_ChIP-Seq_MCF-7_Human1.43751838
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42215504
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42215504
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38558037
61GATA1_22025678_ChIP-Seq_K562_Human1.38155881
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.37784328
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37647452
64TP53_18474530_ChIP-ChIP_U2OS_Human1.36521630
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.34548981
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34153615
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.33544247
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33193570
69ZNF274_21170338_ChIP-Seq_K562_Hela1.32947002
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32218196
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31976697
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30737610
73* TCF4_23295773_ChIP-Seq_U87_Human1.29864359
74BCAT_22108803_ChIP-Seq_LS180_Human1.28598513
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28506152
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28364047
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28364047
78KDM2B_26808549_Chip-Seq_REH_Human1.27129079
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26734379
80CJUN_26792858_Chip-Seq_BT549_Human1.26046803
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25150680
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.23910763
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.23249812
84RNF2_27304074_Chip-Seq_NSC_Mouse1.22403423
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22238383
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21940336
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21029199
88TCF4_22108803_ChIP-Seq_LS180_Human1.20079629
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20041903
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19741674
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.18741839
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18651647
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18328829
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18192792
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18173958
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18159059
97* TP63_23658742_ChIP-Seq_EP156T_Human1.17561656
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17410749
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.17079428
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.17023524
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16106170
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16072385
103CDX2_22108803_ChIP-Seq_LS180_Human1.14751528
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.14245724
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.13797095
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12564371
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12277594
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11291124
109AR_19668381_ChIP-Seq_PC3_Human1.11002431
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10983201
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.10860306
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10357103
113P53_22387025_ChIP-Seq_ESCs_Mouse1.07260225
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.07037409
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.06665444
116JUN_21703547_ChIP-Seq_K562_Human1.06182536
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06141383
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05992527
119CBP_20019798_ChIP-Seq_JUKART_Human1.05992527
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.05575388
121TCF4_18268006_ChIP-ChIP_LS174T_Human1.05573214
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04564498
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04355932
124FUS_26573619_Chip-Seq_HEK293_Human1.04269575
125RXR_22108803_ChIP-Seq_LS180_Human1.04127382
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03876903
127AR_21572438_ChIP-Seq_LNCaP_Human1.03723735
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.03591445
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03364754
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02387931
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.01648652
132* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00179635
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99991585
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99876854
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98696640
136* SMAD4_21741376_ChIP-Seq_EPCs_Human0.98601033
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98418882
138IGF1R_20145208_ChIP-Seq_DFB_Human0.96619087
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96442948
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.96221217
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.96136059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception6.24245194
2MP0002735_abnormal_chemical_nociception6.18229563
3MP0002736_abnormal_nociception_after5.07451832
4MP0004270_analgesia4.61174829
5MP0004859_abnormal_synaptic_plasticity4.15344193
6MP0001986_abnormal_taste_sensitivity3.70849195
7MP0008057_abnormal_DNA_replication3.68293238
8MP0002734_abnormal_mechanical_nocicepti3.59541639
9MP0006276_abnormal_autonomic_nervous3.57776049
10MP0002733_abnormal_thermal_nociception3.56487894
11MP0004858_abnormal_nervous_system3.26041973
12MP0000383_abnormal_hair_follicle3.21224104
13MP0003950_abnormal_plasma_membrane3.13992761
14MP0001970_abnormal_pain_threshold3.04801142
15MP0004084_abnormal_cardiac_muscle2.91221088
16MP0010678_abnormal_skin_adnexa2.88485443
17MP0003880_abnormal_central_pattern2.79889003
18MP0003635_abnormal_synaptic_transmissio2.79122110
19MP0005410_abnormal_fertilization2.60399337
20MP0009745_abnormal_behavioral_response2.55194373
21MP0001879_abnormal_lymphatic_vessel2.41678631
22MP0002272_abnormal_nervous_system2.35310897
23MP0004043_abnormal_pH_regulation2.31820844
24MP0009046_muscle_twitch2.30520457
25MP0002063_abnormal_learning/memory/cond2.25382389
26MP0002067_abnormal_sensory_capabilities2.15085745
27MP0002572_abnormal_emotion/affect_behav2.12413162
28MP0003787_abnormal_imprinting2.09462939
29MP0002822_catalepsy2.05042677
30MP0002009_preneoplasia2.02368414
31MP0002064_seizures2.00770451
32MP0010352_gastrointestinal_tract_polyps1.97327140
33MP0010386_abnormal_urinary_bladder1.92565789
34MP0004742_abnormal_vestibular_system1.91945920
35MP0005187_abnormal_penis_morphology1.91013063
36MP0002184_abnormal_innervation1.84273063
37MP0001440_abnormal_grooming_behavior1.79571415
38MP0010368_abnormal_lymphatic_system1.77553268
39MP0002751_abnormal_autonomic_nervous1.71342663
40MP0003890_abnormal_embryonic-extraembry1.69638916
41MP0002168_other_aberrant_phenotype1.69616848
42MP0004811_abnormal_neuron_physiology1.46367929
43MP0001984_abnormal_olfaction1.42034279
44MP0000013_abnormal_adipose_tissue1.37685267
45MP0008877_abnormal_DNA_methylation1.34318922
46MP0005423_abnormal_somatic_nervous1.33156981
47MP0003122_maternal_imprinting1.30389450
48MP0000566_synostosis1.29486179
49MP0005167_abnormal_blood-brain_barrier1.28277716
50MP0000569_abnormal_digit_pigmentation1.27142005
51MP0001501_abnormal_sleep_pattern1.26638545
52MP0010234_abnormal_vibrissa_follicle1.24890019
53MP0005503_abnormal_tendon_morphology1.23141208
54MP0002160_abnormal_reproductive_system1.22401993
55MP0005310_abnormal_salivary_gland1.21933792
56MP0003633_abnormal_nervous_system1.21768555
57MP0000778_abnormal_nervous_system1.21018491
58MP0004924_abnormal_behavior1.20687716
59MP0005386_behavior/neurological_phenoty1.20687716
60MP0000955_abnormal_spinal_cord1.20612825
61MP0005551_abnormal_eye_electrophysiolog1.19996203
62MP0001905_abnormal_dopamine_level1.19571078
63MP0001486_abnormal_startle_reflex1.18055030
64MP0004272_abnormal_basement_membrane1.16790837
65MP0005174_abnormal_tail_pigmentation1.15331276
66MP0005646_abnormal_pituitary_gland1.12237635
67MP0002638_abnormal_pupillary_reflex1.11578079
68MP0005409_darkened_coat_color1.11217067
69MP0003943_abnormal_hepatobiliary_system1.09898928
70MP0005595_abnormal_vascular_smooth1.07920134
71MP0002557_abnormal_social/conspecific_i1.07912429
72MP0005620_abnormal_muscle_contractility1.07866625
73MP0003329_amyloid_beta_deposits1.07811510
74MP0005275_abnormal_skin_tensile1.07627933
75MP0002882_abnormal_neuron_morphology1.07386362
76MP0000371_diluted_coat_color1.05722549
77MP0001188_hyperpigmentation1.05404877
78MP0009780_abnormal_chondrocyte_physiolo1.04336220
79MP0003137_abnormal_impulse_conducting1.03337799
80MP0003631_nervous_system_phenotype1.01000259
81MP0000372_irregular_coat_pigmentation1.00455258
82MP0000751_myopathy1.00201287
83MP0005253_abnormal_eye_physiology0.99112661
84MP0010307_abnormal_tumor_latency0.98489087
85MP0003646_muscle_fatigue0.98292707
86MP0003941_abnormal_skin_development0.97356958
87MP0001485_abnormal_pinna_reflex0.94916897
88MP0003698_abnormal_male_reproductive0.94593080
89MP0002909_abnormal_adrenal_gland0.94265174
90MP0008872_abnormal_physiological_respon0.91991124
91MP0003879_abnormal_hair_cell0.90508560
92MP0002066_abnormal_motor_capabilities/c0.90373836
93MP0004085_abnormal_heartbeat0.90340207
94MP0001299_abnormal_eye_distance/0.90003862
95MP0008875_abnormal_xenobiotic_pharmacok0.88829515
96MP0003937_abnormal_limbs/digits/tail_de0.88697007
97MP0008874_decreased_physiological_sensi0.88608293
98MP0002837_dystrophic_cardiac_calcinosis0.88317266
99MP0006054_spinal_hemorrhage0.87783127
100MP0003045_fibrosis0.87436462
101MP0008961_abnormal_basal_metabolism0.86013110
102MP0008569_lethality_at_weaning0.85994039
103MP0001270_distended_abdomen0.85875276
104MP0005623_abnormal_meninges_morphology0.83929876
105MP0004484_altered_response_of0.83105768
106MP0000579_abnormal_nail_morphology0.81327150
107MP0003123_paternal_imprinting0.79948225
108MP0006072_abnormal_retinal_apoptosis0.78083973
109MP0003183_abnormal_peptide_metabolism0.77654592
110MP0005171_absent_coat_pigmentation0.77357874
111MP0000427_abnormal_hair_cycle0.76678083
112MP0002925_abnormal_cardiovascular_devel0.74714118
113MP0002928_abnormal_bile_duct0.74240587
114MP0000015_abnormal_ear_pigmentation0.73944156
115MP0009697_abnormal_copulation0.72750424
116MP0003195_calcinosis0.71308530
117MP0002109_abnormal_limb_morphology0.70769471
118MP0000538_abnormal_urinary_bladder0.70527846
119MP0004130_abnormal_muscle_cell0.69816518
120MP0005645_abnormal_hypothalamus_physiol0.68646443
121MP0004381_abnormal_hair_follicle0.68535247
122MP0002332_abnormal_exercise_endurance0.68142309
123MP0000647_abnormal_sebaceous_gland0.67979235
124MP0002108_abnormal_muscle_morphology0.66708554
125MP0001784_abnormal_fluid_regulation0.65657315
126MP0000003_abnormal_adipose_tissue0.64074282
127MP0003935_abnormal_craniofacial_develop0.63033298
128MP0000767_abnormal_smooth_muscle0.62513185
129MP0004215_abnormal_myocardial_fiber0.61748165
130MP0002752_abnormal_somatic_nervous0.60788759
131MP0004134_abnormal_chest_morphology0.60680490
132MP0001502_abnormal_circadian_rhythm0.60590350
133MP0002152_abnormal_brain_morphology0.59876539
134MP0001765_abnormal_ion_homeostasis0.59524367
135MP0001929_abnormal_gametogenesis0.58215412
136MP0002876_abnormal_thyroid_physiology0.57931383
137MP0004036_abnormal_muscle_relaxation0.57640627
138MP0003632_abnormal_nervous_system0.56674349
139MP0001529_abnormal_vocalization0.56122961
140MP0000534_abnormal_ureter_morphology0.54082584
141MP0002229_neurodegeneration0.53001704
142MP0003121_genomic_imprinting0.52466680
143MP0008775_abnormal_heart_ventricle0.50565362
144MP0005535_abnormal_body_temperature0.49875102
145MP0000230_abnormal_systemic_arterial0.49475976
146MP0002069_abnormal_eating/drinking_beha0.49082797
147MP0004145_abnormal_muscle_electrophysio0.48967982
148MP0000749_muscle_degeneration0.48210095
149MP0004142_abnormal_muscle_tone0.47619006
150MP0002161_abnormal_fertility/fecundity0.45987488
151MP0010771_integument_phenotype0.45265925
152MP0001348_abnormal_lacrimal_gland0.44576850
153MP0001963_abnormal_hearing_physiology0.44285761
154MP0001943_abnormal_respiration0.43067971
155MP0002653_abnormal_ependyma_morphology0.42963370
156MP0000604_amyloidosis0.42457326
157MP0004510_myositis0.42365892

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.03958973
2Myokymia (HP:0002411)5.20669854
3Focal seizures (HP:0007359)4.94853277
4Dysmetric saccades (HP:0000641)4.69649423
5Ulnar claw (HP:0001178)4.62964142
6Action tremor (HP:0002345)4.32162074
7Dysautonomia (HP:0002459)4.02097251
8Hypothermia (HP:0002045)4.00782494
9Abnormality of pain sensation (HP:0010832)3.91470282
10Impaired pain sensation (HP:0007328)3.91470282
11Epileptic encephalopathy (HP:0200134)3.85920968
12Termporal pattern (HP:0011008)3.84746551
13Insidious onset (HP:0003587)3.84746551
14Atonic seizures (HP:0010819)3.78714091
15Progressive cerebellar ataxia (HP:0002073)3.77918413
16Febrile seizures (HP:0002373)3.74879671
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.49533689
18Absent/shortened dynein arms (HP:0200106)3.49533689
19Amblyopia (HP:0000646)3.49128739
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.35597597
21Fair hair (HP:0002286)3.19170797
22Pancreatic cysts (HP:0001737)3.14185367
23Abnormal autonomic nervous system physiology (HP:0012332)3.13816129
24Dialeptic seizures (HP:0011146)2.99533318
25Molar tooth sign on MRI (HP:0002419)2.99500155
26Abnormality of midbrain morphology (HP:0002418)2.99500155
27Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.98230718
28Absence seizures (HP:0002121)2.98202030
29Generalized tonic-clonic seizures (HP:0002069)2.95514826
30Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.94437716
31Visual hallucinations (HP:0002367)2.92426397
32Pancreatic fibrosis (HP:0100732)2.88921550
33Nephronophthisis (HP:0000090)2.80997143
34Abnormality of the renal medulla (HP:0100957)2.77400365
35Chronic hepatic failure (HP:0100626)2.75772776
36Orthostatic hypotension (HP:0001278)2.71813677
37Hypoventilation (HP:0002791)2.71719959
38Protruding tongue (HP:0010808)2.70147569
39Generalized hypopigmentation of hair (HP:0011358)2.69663206
40Bradycardia (HP:0001662)2.65351399
41True hermaphroditism (HP:0010459)2.65156678
42Impaired vibration sensation in the lower limbs (HP:0002166)2.63945714
43Ankle clonus (HP:0011448)2.63795111
44Gaze-evoked nystagmus (HP:0000640)2.63436003
45Tubular atrophy (HP:0000092)2.61697925
46Hyperkalemia (HP:0002153)2.59843660
47Hypoplastic labia majora (HP:0000059)2.59076919
48Thyroid carcinoma (HP:0002890)2.56001910
49Hammertoe (HP:0001765)2.55474402
50Abnormality of the lower motor neuron (HP:0002366)2.54274989
51Pheochromocytoma (HP:0002666)2.51359310
52Rhinitis (HP:0012384)2.49390363
53Exotropia (HP:0000577)2.48182688
54Hyperventilation (HP:0002883)2.44675779
55Abnormality of the renal cortex (HP:0011035)2.44100799
56Urinary bladder sphincter dysfunction (HP:0002839)2.43212841
57Truncal ataxia (HP:0002078)2.40606813
58Hypercortisolism (HP:0001578)2.39105711
59Short chin (HP:0000331)2.39051584
60Cystic liver disease (HP:0006706)2.38651155
61Lip pit (HP:0100267)2.38149527
62Abnormality of the labia majora (HP:0012881)2.36324568
63Urinary urgency (HP:0000012)2.35948109
64Abnormality of the corticospinal tract (HP:0002492)2.35857139
65Decreased circulating renin level (HP:0003351)2.32161084
66Abnormal respiratory motile cilium physiology (HP:0012261)2.31757447
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30033759
68Hypoplasia of the brainstem (HP:0002365)2.30033759
69Horizontal nystagmus (HP:0000666)2.29460333
70Widely spaced teeth (HP:0000687)2.28730549
71Bronchiectasis (HP:0002110)2.28704092
72Menstrual irregularities (HP:0000858)2.25984556
73Steppage gait (HP:0003376)2.25611729
74Autoamputation (HP:0001218)2.25508728
75Aqueductal stenosis (HP:0002410)2.24661175
76Supranuclear gaze palsy (HP:0000605)2.22379827
77Epileptiform EEG discharges (HP:0011182)2.22249284
78Myotonia (HP:0002486)2.21657238
79Impaired smooth pursuit (HP:0007772)2.21292935
80Neuroendocrine neoplasm (HP:0100634)2.20676056
81Arthropathy (HP:0003040)2.19358003
82Furrowed tongue (HP:0000221)2.18799684
83Abnormality of the nasal septum (HP:0000419)2.13613453
84Segmental peripheral demyelination/remyelination (HP:0003481)2.11014164
85Hyporeflexia of lower limbs (HP:0002600)2.09842083
86Lower limb muscle weakness (HP:0007340)2.07598153
87Abnormal eating behavior (HP:0100738)2.07412881
88Depression (HP:0000716)2.06096962
89Failure to thrive in infancy (HP:0001531)2.05393035
90Abnormality of ocular smooth pursuit (HP:0000617)2.03425449
91Medial flaring of the eyebrow (HP:0010747)2.03099987
92Abnormal respiratory epithelium morphology (HP:0012253)2.03003821
93Abnormal respiratory motile cilium morphology (HP:0005938)2.03003821
94Decreased motor nerve conduction velocity (HP:0003431)1.99081993
95EEG with generalized epileptiform discharges (HP:0011198)1.97827657
96Distal sensory impairment (HP:0002936)1.97804944
97Agitation (HP:0000713)1.96253362
98Limb dystonia (HP:0002451)1.95609366
99Polyphagia (HP:0002591)1.95032838
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.94225940
101Dysmetria (HP:0001310)1.93876688
102Foot dorsiflexor weakness (HP:0009027)1.92399219
103Congenital hepatic fibrosis (HP:0002612)1.92370073
104Inability to walk (HP:0002540)1.92187047
105Clumsiness (HP:0002312)1.90809160
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90705076
107Abnormality of the ischium (HP:0003174)1.90638317
108Abnormality of the fingertips (HP:0001211)1.90516305
109Overgrowth (HP:0001548)1.89823374
110Abnormal ciliary motility (HP:0012262)1.89809005
111Infertility (HP:0000789)1.89637554
112Absent speech (HP:0001344)1.89614815
113Abnormal hair whorl (HP:0010721)1.89370817
114Spastic gait (HP:0002064)1.88230289
115Chromsome breakage (HP:0040012)1.87990463
116Hyperthyroidism (HP:0000836)1.87886982
117Truncal obesity (HP:0001956)1.87869523
118Abnormality of chloride homeostasis (HP:0011422)1.86983143
119Broad-based gait (HP:0002136)1.86688014
120Tubulointerstitial nephritis (HP:0001970)1.86525815
121Drooling (HP:0002307)1.85665588
122Excessive salivation (HP:0003781)1.85665588
123Poor coordination (HP:0002370)1.85093548
124Hemiparesis (HP:0001269)1.83628683
125Dysdiadochokinesis (HP:0002075)1.82609135
126Genetic anticipation (HP:0003743)1.82389268
127Aortic aneurysm (HP:0004942)1.80024602
128Hypoplastic ischia (HP:0003175)1.79009307
129Hypsarrhythmia (HP:0002521)1.77736684
130Postural instability (HP:0002172)1.76978780
131Atrial fibrillation (HP:0005110)1.75640866
132Recurrent corneal erosions (HP:0000495)1.75249995
133Onion bulb formation (HP:0003383)1.73972738
134Broad distal phalanx of finger (HP:0009836)1.73379605
135Poor eye contact (HP:0000817)1.72719475
136Scanning speech (HP:0002168)1.72573068
137Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71911310
138Choroideremia (HP:0001139)1.71862839
139Retinal dysplasia (HP:0007973)1.71720259
140Lower limb amyotrophy (HP:0007210)1.71648942
141Congenital primary aphakia (HP:0007707)1.71287830
142Impaired vibratory sensation (HP:0002495)1.69772072
143Abnormality of the renal collecting system (HP:0004742)1.69466496
144Duplicated collecting system (HP:0000081)1.68685752
145Central scotoma (HP:0000603)1.68134281
146Type II lissencephaly (HP:0007260)1.67636041
147Highly arched eyebrow (HP:0002553)1.66284811
148Absent frontal sinuses (HP:0002688)1.66246862
149Syncope (HP:0001279)1.66213517
150Gait imbalance (HP:0002141)1.65982984
151Macroorchidism (HP:0000053)1.65271768
152Papillary thyroid carcinoma (HP:0002895)1.64532612
153Hamartoma of the eye (HP:0010568)1.64440696
154Blue irides (HP:0000635)1.64426965
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.63666470
156Volvulus (HP:0002580)1.61968205
157Postaxial foot polydactyly (HP:0001830)1.61879768
158Midline defect of the nose (HP:0004122)1.61624066
159Sandal gap (HP:0001852)1.61480797
160Cerebellar dysplasia (HP:0007033)1.59242500
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59123995
162Postural tremor (HP:0002174)1.58786249
163Birth length less than 3rd percentile (HP:0003561)1.58412467
164Polydipsia (HP:0001959)1.58059496
165Abnormal drinking behavior (HP:0030082)1.58059496
166Congenital sensorineural hearing impairment (HP:0008527)1.57823608
167Depressed nasal tip (HP:0000437)1.57229942
168Abnormality of the epiphyses of the hand (HP:0005924)1.56862518
169Portal hypertension (HP:0001409)1.56813550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.42954135
2NTRK14.21057234
3RIPK43.40760371
4ACVR1B3.37887337
5MAP3K92.99630207
6CASK2.92203206
7MAP3K42.69098370
8MINK12.49412434
9EPHA42.48625048
10STK392.45951998
11KSR22.45166970
12TRPM72.21045448
13MAP2K72.10936143
14MATK2.07738982
15GRK52.01774380
16DAPK22.00397314
17EEF2K1.98679388
18MST1R1.95537542
19STK38L1.94712411
20MAP3K21.86767847
21PRKD31.85798512
22PRPF4B1.85205326
23PTK2B1.76956463
24PDK31.76080534
25PDK41.76080534
26LATS11.64816243
27MAP3K121.64377587
28MAP2K41.63472900
29CDK121.58693407
30SGK21.55466150
31CAMK1D1.53766866
32PAK61.53623900
33MET1.51896346
34FER1.51451543
35TGFBR11.46793377
36SIK31.45625400
37SGK4941.43677154
38SGK2231.43677154
39CAMKK21.38746514
40DAPK11.34453742
41RET1.33234940
42TIE11.29516436
43PIK3CA1.28796998
44MKNK21.27482108
45MYLK1.27014739
46EPHA31.26762579
47OXSR11.26225088
48PLK21.25250725
49LMTK21.25231801
50AKT31.24493528
51MELK1.24037458
52MAPK151.23992550
53INSRR1.21760759
54MAPK131.19385936
55PRKCG1.16471083
56BRSK21.15725451
57ADRBK21.12446456
58CDK51.12341513
59ARAF1.12103944
60SGK31.09315568
61NLK1.07863214
62LATS21.06140233
63MAP2K11.06044030
64PDK21.05547603
65MARK11.05536376
66WNK41.04230588
67KSR11.02946724
68TESK11.01515468
69STK241.00030793
70PRKCE0.95222187
71NUAK10.94542261
72PRKAA20.93041357
73MAP3K70.92563628
74MARK30.88999017
75CAMK2A0.87873327
76CAMKK10.87576735
77NEK90.86979673
78STK30.85366606
79CSNK1A1L0.85142629
80FES0.85020123
81BRD40.81283587
82NTRK20.81190580
83GRK10.80780231
84PDK10.79611696
85DMPK0.78960113
86PNCK0.74696404
87RPS6KA20.73468892
88FGFR20.73266491
89MAPKAPK50.73021053
90MAP3K10.72636356
91PDPK10.72216301
92CDK140.70783223
93STK380.67300181
94CHUK0.67278897
95ADRBK10.65521155
96FRK0.65161500
97PRKAA10.62783880
98CAMK2B0.59393448
99LIMK10.57993115
100GRK70.57639198
101CDK180.57388816
102OBSCN0.56744536
103MAP3K130.55397586
104MAPK110.54228863
105CSNK1G20.54007351
106MTOR0.52911916
107TEC0.51648807
108EPHA20.51560706
109BRAF0.51214915
110MST40.50936304
111ERBB30.50783964
112PINK10.50549810
113RPS6KB20.49793611
114MAP4K20.49504841
115PHKG10.48561311
116PHKG20.48561311
117YES10.48557619
118CAMK1G0.48244366
119CDK150.47927900
120MARK20.47308974
121PDGFRA0.47157619
122PTK20.46771266
123PRKCZ0.46043804
124CAMK40.44704512
125BMPR1B0.44469481
126SGK10.44429072
127TAF10.43994200
128CCNB10.42559767
129JAK10.42399659
130PRKCH0.41711739
131PAK30.41676400
132PRKG20.41227262
133BCR0.39162587
134ATM0.39026101
135WNK30.38977594
136CAMK2D0.38871967
137CDC42BPA0.37289292
138WNK10.37099810
139CDK30.36893803
140CSNK1G10.35064097
141CDK11A0.34189735
142TNIK0.34094683
143PDGFRB0.33803906
144MAPK70.32897293
145SRC0.32105629
146NEK60.31877987
147MAPKAPK30.31378181
148PRKACA0.30801786
149PRKCB0.30517188
150MAPK100.30514016
151ITK0.30400835
152CAMK10.27718979
153RPS6KA30.27392767
154STK110.27048576
155CAMK2G0.26437142
156FGR0.25372039
157BMPR20.25087978
158FGFR30.24924037

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.04980432
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.74577471
3Nitrogen metabolism_Homo sapiens_hsa009102.56853590
4Nicotine addiction_Homo sapiens_hsa050332.46782818
5Long-term potentiation_Homo sapiens_hsa047202.42608973
6Circadian entrainment_Homo sapiens_hsa047132.39463194
7Insulin secretion_Homo sapiens_hsa049112.27966868
8Amphetamine addiction_Homo sapiens_hsa050312.26979623
9Olfactory transduction_Homo sapiens_hsa047402.17507966
10Dopaminergic synapse_Homo sapiens_hsa047282.10830600
11Glutamatergic synapse_Homo sapiens_hsa047242.09147530
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.08427669
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00954047
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97447223
15Taste transduction_Homo sapiens_hsa047421.96429414
16Salivary secretion_Homo sapiens_hsa049701.93092608
17Morphine addiction_Homo sapiens_hsa050321.87669977
18Cholinergic synapse_Homo sapiens_hsa047251.81036953
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.80603611
20Renin secretion_Homo sapiens_hsa049241.80380980
21ABC transporters_Homo sapiens_hsa020101.68947140
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67950077
23Serotonergic synapse_Homo sapiens_hsa047261.66499449
24Collecting duct acid secretion_Homo sapiens_hsa049661.66427600
25Long-term depression_Homo sapiens_hsa047301.61041851
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57904097
27GABAergic synapse_Homo sapiens_hsa047271.55968572
28Calcium signaling pathway_Homo sapiens_hsa040201.55462822
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52588177
30GnRH signaling pathway_Homo sapiens_hsa049121.46953217
31Cocaine addiction_Homo sapiens_hsa050301.40185705
32Gastric acid secretion_Homo sapiens_hsa049711.39999766
33Oxytocin signaling pathway_Homo sapiens_hsa049211.36553079
34Dorso-ventral axis formation_Homo sapiens_hsa043201.33509892
35Type II diabetes mellitus_Homo sapiens_hsa049301.32141031
36Estrogen signaling pathway_Homo sapiens_hsa049151.31831122
37* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31711744
38Gap junction_Homo sapiens_hsa045401.28582959
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.18950693
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15568656
41cAMP signaling pathway_Homo sapiens_hsa040241.14938336
42Vibrio cholerae infection_Homo sapiens_hsa051101.14481789
43ECM-receptor interaction_Homo sapiens_hsa045121.14141951
44Adherens junction_Homo sapiens_hsa045201.13410235
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11485503
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08788526
47Glioma_Homo sapiens_hsa052141.07385091
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04691969
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02620198
50Non-homologous end-joining_Homo sapiens_hsa034501.01852169
51TGF-beta signaling pathway_Homo sapiens_hsa043501.01304316
52Tight junction_Homo sapiens_hsa045300.99179084
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98625935
54Melanogenesis_Homo sapiens_hsa049160.98273649
55Oocyte meiosis_Homo sapiens_hsa041140.97464399
56Pancreatic secretion_Homo sapiens_hsa049720.97019052
57Selenocompound metabolism_Homo sapiens_hsa004500.96366604
58ErbB signaling pathway_Homo sapiens_hsa040120.93832117
59Fatty acid biosynthesis_Homo sapiens_hsa000610.93525820
60Lysine degradation_Homo sapiens_hsa003100.93518668
61Thyroid hormone synthesis_Homo sapiens_hsa049180.91277306
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.90784088
63* Phospholipase D signaling pathway_Homo sapiens_hsa040720.89716650
64Focal adhesion_Homo sapiens_hsa045100.89099145
65MicroRNAs in cancer_Homo sapiens_hsa052060.88813686
66Axon guidance_Homo sapiens_hsa043600.88707624
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87996996
68Cardiac muscle contraction_Homo sapiens_hsa042600.86368974
69Platelet activation_Homo sapiens_hsa046110.85354952
70Sphingolipid metabolism_Homo sapiens_hsa006000.85070885
71VEGF signaling pathway_Homo sapiens_hsa043700.84235084
72FoxO signaling pathway_Homo sapiens_hsa040680.83992697
73Glucagon signaling pathway_Homo sapiens_hsa049220.83162273
74Small cell lung cancer_Homo sapiens_hsa052220.81665369
75Linoleic acid metabolism_Homo sapiens_hsa005910.81528208
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80991397
77MAPK signaling pathway_Homo sapiens_hsa040100.77822082
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77588941
79* Choline metabolism in cancer_Homo sapiens_hsa052310.75564601
80Rap1 signaling pathway_Homo sapiens_hsa040150.75203026
81Thyroid cancer_Homo sapiens_hsa052160.74900848
82Ether lipid metabolism_Homo sapiens_hsa005650.74677079
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73720752
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71083798
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70711897
86Fanconi anemia pathway_Homo sapiens_hsa034600.70409752
87Proteoglycans in cancer_Homo sapiens_hsa052050.70063425
88Hippo signaling pathway_Homo sapiens_hsa043900.69773515
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69380419
90Renin-angiotensin system_Homo sapiens_hsa046140.68247278
91Mineral absorption_Homo sapiens_hsa049780.68129608
92Ras signaling pathway_Homo sapiens_hsa040140.65060678
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.64276157
94Ovarian steroidogenesis_Homo sapiens_hsa049130.63768880
95mTOR signaling pathway_Homo sapiens_hsa041500.63409419
96Dilated cardiomyopathy_Homo sapiens_hsa054140.62853853
97Insulin signaling pathway_Homo sapiens_hsa049100.62579293
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61086463
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60665480
100African trypanosomiasis_Homo sapiens_hsa051430.60425951
101Endocytosis_Homo sapiens_hsa041440.59438977
102Endometrial cancer_Homo sapiens_hsa052130.58417251
103Melanoma_Homo sapiens_hsa052180.55689508
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.55389497
105TNF signaling pathway_Homo sapiens_hsa046680.55354408
106Phagosome_Homo sapiens_hsa041450.54736460
107Bile secretion_Homo sapiens_hsa049760.53896393
108Prostate cancer_Homo sapiens_hsa052150.51785929
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51391984
110Insulin resistance_Homo sapiens_hsa049310.51002446
111Circadian rhythm_Homo sapiens_hsa047100.49018798
112Salmonella infection_Homo sapiens_hsa051320.48682236
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48541131
114* Glycerophospholipid metabolism_Homo sapiens_hsa005640.46625063
115Prolactin signaling pathway_Homo sapiens_hsa049170.44762599
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43392313
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43391890
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.43113582
119Pathways in cancer_Homo sapiens_hsa052000.42722094
120Phototransduction_Homo sapiens_hsa047440.42260380
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42103806
122Basal transcription factors_Homo sapiens_hsa030220.41489846
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41055197
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40738690
125Rheumatoid arthritis_Homo sapiens_hsa053230.40594694
126Alcoholism_Homo sapiens_hsa050340.40266917
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39802988
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39748305
129Renal cell carcinoma_Homo sapiens_hsa052110.39682895
130Amoebiasis_Homo sapiens_hsa051460.39505276
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38987656
132Wnt signaling pathway_Homo sapiens_hsa043100.38697800
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35682788
134Hedgehog signaling pathway_Homo sapiens_hsa043400.35202148
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34945301
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33602195
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32396417
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30244337
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29528617

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