DGKI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.66130424
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57546761
3negative regulation of hormone biosynthetic process (GO:0032353)5.52448736
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50039758
5synaptic vesicle maturation (GO:0016188)5.15018354
6locomotory exploration behavior (GO:0035641)5.00643014
7cardiac chamber formation (GO:0003207)4.94991055
8negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.94875648
9positive regulation of cardiac muscle cell differentiation (GO:2000727)4.92634328
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88198507
11synaptic vesicle exocytosis (GO:0016079)4.74445167
12negative regulation of hormone metabolic process (GO:0032351)4.68994093
13vocalization behavior (GO:0071625)4.64717102
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59104776
15glutamate secretion (GO:0014047)4.58330371
16protein localization to synapse (GO:0035418)4.55883275
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.49007799
18regulation of glutamate receptor signaling pathway (GO:1900449)4.46916327
19regulation of synaptic vesicle exocytosis (GO:2000300)4.45138233
20myofibril assembly (GO:0030239)4.39290813
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.37239274
22cardiac ventricle formation (GO:0003211)4.36862325
23regulation of synapse structural plasticity (GO:0051823)4.29969514
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.21229748
25neuron cell-cell adhesion (GO:0007158)4.19718397
26cell communication by electrical coupling (GO:0010644)4.19671355
27regulation of neuronal synaptic plasticity (GO:0048168)4.18829817
28synaptic transmission, glutamatergic (GO:0035249)4.17218245
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16820352
30positive regulation of dendritic spine morphogenesis (GO:0061003)4.16504886
31glutamate receptor signaling pathway (GO:0007215)4.15956866
32neuronal action potential propagation (GO:0019227)4.11947145
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04993128
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04584618
35neuron-neuron synaptic transmission (GO:0007270)4.04190490
36exploration behavior (GO:0035640)3.98541314
37regulation of synaptic vesicle transport (GO:1902803)3.97922982
38neurotransmitter-gated ion channel clustering (GO:0072578)3.97431818
39cardiac muscle hypertrophy (GO:0003300)3.90383044
40regulation of glucocorticoid metabolic process (GO:0031943)3.90095451
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.88093520
42membrane depolarization during action potential (GO:0086010)3.84934174
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83251763
44regulation of skeletal muscle cell differentiation (GO:2001014)3.78231289
45neurotransmitter secretion (GO:0007269)3.75352968
46cellular potassium ion homeostasis (GO:0030007)3.71168042
47regulation of cardioblast differentiation (GO:0051890)3.70665045
48long-term memory (GO:0007616)3.69965168
49cerebral cortex radially oriented cell migration (GO:0021799)3.68062015
50regulation of postsynaptic membrane potential (GO:0060078)3.67246559
51striated muscle hypertrophy (GO:0014897)3.66344149
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64938501
53regulation of cardiac muscle cell differentiation (GO:2000725)3.64909185
54positive regulation of membrane potential (GO:0045838)3.63532186
55prepulse inhibition (GO:0060134)3.63200836
56dendritic spine morphogenesis (GO:0060997)3.62358267
57layer formation in cerebral cortex (GO:0021819)3.62057610
58proline transport (GO:0015824)3.61464618
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.60926525
60membrane hyperpolarization (GO:0060081)3.60381033
61regulation of sarcomere organization (GO:0060297)3.59574328
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.58714864
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57291456
64regulation of synaptic plasticity (GO:0048167)3.54560296
65long-term synaptic potentiation (GO:0060291)3.53008073
66cell communication involved in cardiac conduction (GO:0086065)3.52463413
67regulation of dendritic spine morphogenesis (GO:0061001)3.52339566
68negative regulation of dendrite morphogenesis (GO:0050774)3.52234020
69negative regulation of dendrite development (GO:2000171)3.50756730
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.45868644
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43610501
72cerebellar Purkinje cell differentiation (GO:0021702)3.43048251
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.42097648
74neuronal action potential (GO:0019228)3.42079246
75gamma-aminobutyric acid transport (GO:0015812)3.39831485
76membrane depolarization (GO:0051899)3.38660301
77male genitalia development (GO:0030539)3.34488496
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32757147
79neuron recognition (GO:0008038)3.31969129
80dendrite morphogenesis (GO:0048813)3.30809911
81regulation of relaxation of muscle (GO:1901077)3.27772088
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27548075
83transmission of nerve impulse (GO:0019226)3.27327666
84neuromuscular process controlling balance (GO:0050885)3.26791807
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25822966
86vesicle transport along microtubule (GO:0047496)3.24804862
87activation of protein kinase A activity (GO:0034199)3.24219073
88striatum development (GO:0021756)3.22959855
89central nervous system projection neuron axonogenesis (GO:0021952)3.22737693
90axonal fasciculation (GO:0007413)3.20651446
91sodium ion export (GO:0071436)3.20490072
92long term synaptic depression (GO:0060292)3.19673432
93positive regulation of synapse maturation (GO:0090129)3.19515901
94behavioral response to cocaine (GO:0048148)3.17931300
95behavioral fear response (GO:0001662)3.17688945
96behavioral defense response (GO:0002209)3.17688945
97dopamine receptor signaling pathway (GO:0007212)3.17499451
98innervation (GO:0060384)3.15533577
99regulation of synapse assembly (GO:0051963)3.15370350
100muscle hypertrophy (GO:0014896)3.14180324
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.13933937
102positive regulation of cardiac muscle tissue development (GO:0055025)3.13804741
103regulation of neurotransmitter secretion (GO:0046928)3.12448832
104presynaptic membrane assembly (GO:0097105)3.11453862
105response to histamine (GO:0034776)3.11125274
106positive regulation of neurotransmitter transport (GO:0051590)3.09395818
107response to auditory stimulus (GO:0010996)3.08722679
108auditory behavior (GO:0031223)3.05344936
109regulation of voltage-gated calcium channel activity (GO:1901385)3.04172642
110synapse assembly (GO:0007416)3.02590616
111neurotransmitter transport (GO:0006836)3.02364871
112regulation of vesicle fusion (GO:0031338)3.02088293
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01959616
114learning (GO:0007612)3.01181200
115neuronal ion channel clustering (GO:0045161)3.00328669
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99077288
117negative regulation of striated muscle cell apoptotic process (GO:0010664)2.97966218
118regulation of neurotransmitter transport (GO:0051588)2.97256748
119positive regulation of neurotransmitter secretion (GO:0001956)2.97039550
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96846010
121regulation of transforming growth factor beta2 production (GO:0032909)2.96628553
122positive regulation of synaptic transmission (GO:0050806)2.95597677
123presynaptic membrane organization (GO:0097090)2.95134602
124synaptic vesicle endocytosis (GO:0048488)2.94395044
125membrane assembly (GO:0071709)2.94011492
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93821791
127regulation of dendritic spine development (GO:0060998)2.93247370
128positive regulation of synapse assembly (GO:0051965)2.92754330
129endocardial cushion morphogenesis (GO:0003203)2.92746117
130synaptic transmission (GO:0007268)2.92550613
131fear response (GO:0042596)2.90777484
132glycine transport (GO:0015816)2.89480551
133cardiac conduction (GO:0061337)2.88782254
134postsynaptic membrane organization (GO:0001941)2.88429008
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.87945007
136regulation of cardiac muscle cell apoptotic process (GO:0010665)2.87538659
137cartilage morphogenesis (GO:0060536)2.86913822
138regulation of steroid hormone biosynthetic process (GO:0090030)2.85175075
139cerebral cortex cell migration (GO:0021795)2.81908003
140cerebellar granule cell differentiation (GO:0021707)2.79173382
141adult heart development (GO:0007512)2.77294157
142cardiac right ventricle morphogenesis (GO:0003215)2.75634513
143positive regulation of dendritic spine development (GO:0060999)2.73373926
144positive regulation of dendrite development (GO:1900006)2.73211409
145cardiac muscle adaptation (GO:0014887)2.73124918
146cardiac muscle hypertrophy in response to stress (GO:0014898)2.73124918
147muscle hypertrophy in response to stress (GO:0003299)2.73124918
148positive regulation of cardiac muscle tissue growth (GO:0055023)2.73114825
149positive regulation of cardiac muscle cell proliferation (GO:0060045)2.71949180
150heart field specification (GO:0003128)2.70874823
151secondary heart field specification (GO:0003139)2.70874823
152reproductive system development (GO:0061458)2.70772137
153atrial septum morphogenesis (GO:0060413)2.68899027
154regulation of synapse maturation (GO:0090128)2.68622648
155regulation of pigment cell differentiation (GO:0050932)2.66693369
156cardiac muscle cell development (GO:0055013)2.66597727
157limb bud formation (GO:0060174)2.66422404
158central nervous system neuron axonogenesis (GO:0021955)2.66387401
159multicellular organismal signaling (GO:0035637)2.64982474
160cardiac muscle contraction (GO:0060048)2.64053406
161regulation of synapse organization (GO:0050807)2.63958951
162relaxation of smooth muscle (GO:0044557)2.61869748
163cardiac cell development (GO:0055006)2.61751581
164regulation of cardiac muscle cell contraction (GO:0086004)2.61486888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22833759
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.11055610
3GBX2_23144817_ChIP-Seq_PC3_Human4.02402524
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04052971
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96312947
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89230195
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57818186
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57818186
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.56295069
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52900675
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52519828
12DROSHA_22980978_ChIP-Seq_HELA_Human2.51717712
13REST_21632747_ChIP-Seq_MESCs_Mouse2.49881754
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46535729
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42166593
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41775131
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37687773
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37387723
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.36797109
20AR_21572438_ChIP-Seq_LNCaP_Human2.19373173
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.16450215
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11708984
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09087439
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.08300206
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.07720393
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.07579466
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.00158177
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94466708
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.89269607
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87557290
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86972045
32* FUS_26573619_Chip-Seq_HEK293_Human1.81124842
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.78554848
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73031057
35TAF15_26573619_Chip-Seq_HEK293_Human1.69093466
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66471293
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63878196
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63640976
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55756054
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54409654
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48013234
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47537991
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.46149325
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45934445
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43824253
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43415906
47* P300_19829295_ChIP-Seq_ESCs_Human1.41977488
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.41293683
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.40778803
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.40542784
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.40017572
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.39231480
53* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38450688
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37800770
55* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37684207
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35997747
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35997747
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34489281
59* STAT3_23295773_ChIP-Seq_U87_Human1.34210635
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32596121
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.31560334
62AR_25329375_ChIP-Seq_VCAP_Human1.30552189
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28768997
64SOX9_26525672_Chip-Seq_HEART_Mouse1.28688095
65ZNF274_21170338_ChIP-Seq_K562_Hela1.28391930
66* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28371498
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.28068722
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27884680
69AHR_22903824_ChIP-Seq_MCF-7_Human1.27750706
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27338663
71EWS_26573619_Chip-Seq_HEK293_Human1.26436309
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.26138120
73IGF1R_20145208_ChIP-Seq_DFB_Human1.24917285
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24753808
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24410895
76* AR_19668381_ChIP-Seq_PC3_Human1.24216163
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23548200
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21840408
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21705309
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.21306709
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19777615
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.18147575
83TCF4_23295773_ChIP-Seq_U87_Human1.17635163
84TP53_16413492_ChIP-PET_HCT116_Human1.16363390
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16169416
86* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15712689
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12719521
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12362433
89VDR_22108803_ChIP-Seq_LS180_Human1.11922115
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10814824
91BCAT_22108803_ChIP-Seq_LS180_Human1.10814045
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10091263
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09881154
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.09687522
95* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09514941
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09474698
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09213433
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.09069369
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08917853
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.08664044
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08569449
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08247136
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07443723
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03721582
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03032960
106* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02461808
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.02458060
108RUNX2_22187159_ChIP-Seq_PCA_Human1.01359262
109* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00256529
110* SMAD3_21741376_ChIP-Seq_ESCs_Human1.00023536
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99356094
112TP53_18474530_ChIP-ChIP_U2OS_Human0.98668615
113RNF2_27304074_Chip-Seq_NSC_Mouse0.98643098
114KDM2B_26808549_Chip-Seq_K562_Human0.97088015
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96642767
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96303492
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96303492
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.96094894
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95126221
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93053819
121JUN_21703547_ChIP-Seq_K562_Human0.92534320
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92090451
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90944224
124RXR_22108803_ChIP-Seq_LS180_Human0.90564424
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89593349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03722129
2MP0002102_abnormal_ear_morphology4.62575095
3MP0003880_abnormal_central_pattern4.57874403
4MP0001968_abnormal_touch/_nociception4.43064479
5MP0004270_analgesia4.02242549
6MP0003635_abnormal_synaptic_transmissio3.89357080
7MP0002736_abnormal_nociception_after3.72892789
8MP0002822_catalepsy3.65512854
9MP0003941_abnormal_skin_development3.42245572
10MP0002735_abnormal_chemical_nociception3.36619857
11MP0009745_abnormal_behavioral_response3.21589070
12MP0002063_abnormal_learning/memory/cond3.19937078
13MP0002734_abnormal_mechanical_nocicepti2.92313478
14MP0009046_muscle_twitch2.91874628
15MP0002064_seizures2.89610286
16MP0004510_myositis2.81746163
17MP0002272_abnormal_nervous_system2.72882882
18MP0002572_abnormal_emotion/affect_behav2.66299378
19MP0005423_abnormal_somatic_nervous2.57089410
20MP0002733_abnormal_thermal_nociception2.52134993
21MP0001486_abnormal_startle_reflex2.52059807
22MP0001970_abnormal_pain_threshold2.33020237
23MP0004858_abnormal_nervous_system2.09747460
24MP0002067_abnormal_sensory_capabilities2.08363487
25MP0001986_abnormal_taste_sensitivity2.05144012
26MP0001984_abnormal_olfaction1.97322108
27MP0009250_abnormal_appendicular_skeleto1.96727928
28MP0001501_abnormal_sleep_pattern1.92445921
29MP0004084_abnormal_cardiac_muscle1.88174714
30MP0003385_abnormal_body_wall1.86944112
31MP0001958_emphysema1.79563769
32MP0003329_amyloid_beta_deposits1.79456934
33MP0002184_abnormal_innervation1.79096135
34MP0001440_abnormal_grooming_behavior1.79044049
35MP0005248_abnormal_Harderian_gland1.78027904
36MP0000778_abnormal_nervous_system1.77163770
37MP0004811_abnormal_neuron_physiology1.75641443
38MP0008569_lethality_at_weaning1.74389425
39MP0004885_abnormal_endolymph1.69400533
40MP0005386_behavior/neurological_phenoty1.68238818
41MP0004924_abnormal_behavior1.68238818
42MP0002557_abnormal_social/conspecific_i1.65538937
43MP0006276_abnormal_autonomic_nervous1.61610773
44MP0002909_abnormal_adrenal_gland1.56931148
45MP0008775_abnormal_heart_ventricle1.55832133
46MP0000462_abnormal_digestive_system1.53167140
47MP0005646_abnormal_pituitary_gland1.52479839
48MP0000955_abnormal_spinal_cord1.47872697
49MP0009780_abnormal_chondrocyte_physiolo1.47590570
50MP0003879_abnormal_hair_cell1.42466364
51MP0002233_abnormal_nose_morphology1.42217610
52MP0003633_abnormal_nervous_system1.41605001
53MP0002882_abnormal_neuron_morphology1.39526413
54MP0003937_abnormal_limbs/digits/tail_de1.36277756
55MP0003787_abnormal_imprinting1.35809270
56MP0001529_abnormal_vocalization1.34040913
57MP0000569_abnormal_digit_pigmentation1.32355402
58MP0002066_abnormal_motor_capabilities/c1.31928763
59MP0004742_abnormal_vestibular_system1.18234495
60MP0003935_abnormal_craniofacial_develop1.17582420
61MP0002249_abnormal_larynx_morphology1.16329792
62MP0003631_nervous_system_phenotype1.15315884
63MP0001188_hyperpigmentation1.13191214
64MP0001905_abnormal_dopamine_level1.12159773
65MP0004142_abnormal_muscle_tone1.11755839
66MP0005645_abnormal_hypothalamus_physiol1.10811199
67MP0002697_abnormal_eye_size1.10461101
68MP0002229_neurodegeneration1.07265942
69MP0003890_abnormal_embryonic-extraembry1.06874547
70MP0002972_abnormal_cardiac_muscle1.05274906
71MP0001177_atelectasis1.04530007
72MP0001502_abnormal_circadian_rhythm1.03207185
73MP0008874_decreased_physiological_sensi1.02308030
74MP0000639_abnormal_adrenal_gland1.01567938
75MP0002127_abnormal_cardiovascular_syste0.99963976
76MP0008872_abnormal_physiological_respon0.99169606
77MP0005620_abnormal_muscle_contractility0.98254930
78MP0002152_abnormal_brain_morphology0.97512896
79MP0005551_abnormal_eye_electrophysiolog0.96424973
80MP0004036_abnormal_muscle_relaxation0.96155931
81MP0000733_abnormal_muscle_development0.95100604
82MP0003119_abnormal_digestive_system0.94671398
83MP0010386_abnormal_urinary_bladder0.88483717
84MP0003950_abnormal_plasma_membrane0.88002030
85MP0001485_abnormal_pinna_reflex0.87428177
86MP0003755_abnormal_palate_morphology0.86957405
87MP0005409_darkened_coat_color0.86904163
88MP0004085_abnormal_heartbeat0.85898762
89MP0000749_muscle_degeneration0.85528266
90MP0003634_abnormal_glial_cell0.85399987
91MP0000920_abnormal_myelination0.82772964
92MP0004272_abnormal_basement_membrane0.80603336
93MP0003690_abnormal_glial_cell0.79691561
94MP0003115_abnormal_respiratory_system0.79668043
95MP0002109_abnormal_limb_morphology0.79417721
96MP0002177_abnormal_outer_ear0.79224987
97MP0002069_abnormal_eating/drinking_beha0.79189059
98MP0009053_abnormal_anal_canal0.78963214
99MP0001963_abnormal_hearing_physiology0.78916614
100MP0000604_amyloidosis0.78551184
101MP0002752_abnormal_somatic_nervous0.78474546
102MP0003075_altered_response_to0.78439299
103MP0010234_abnormal_vibrissa_follicle0.78273260
104MP0004145_abnormal_muscle_electrophysio0.76935176
105MP0009384_cardiac_valve_regurgitation0.74691065
106MP0000428_abnormal_craniofacial_morphol0.74316750
107MP0003632_abnormal_nervous_system0.73321064
108MP0005503_abnormal_tendon_morphology0.72375745
109MP0000767_abnormal_smooth_muscle0.71573399
110MP0000751_myopathy0.70980229
111MP0005394_taste/olfaction_phenotype0.70554371
112MP0005499_abnormal_olfactory_system0.70554371
113MP0002837_dystrophic_cardiac_calcinosis0.67432100
114MP0000631_abnormal_neuroendocrine_gland0.66969506
115MP0002090_abnormal_vision0.66890185
116MP0005195_abnormal_posterior_eye0.66364368
117MP0002081_perinatal_lethality0.65977866
118MP0002133_abnormal_respiratory_system0.65176671
119MP0003137_abnormal_impulse_conducting0.63981100
120MP0003122_maternal_imprinting0.62670317
121MP0001664_abnormal_digestion0.62205986
122MP0001299_abnormal_eye_distance/0.60409960
123MP0005171_absent_coat_pigmentation0.60026001
124MP0005535_abnormal_body_temperature0.57149198
125MP0003045_fibrosis0.56586457
126MP0001943_abnormal_respiration0.56156922
127MP0002638_abnormal_pupillary_reflex0.55962045
128MP0004484_altered_response_of0.53348381
129MP0002751_abnormal_autonomic_nervous0.53018624
130MP0000013_abnormal_adipose_tissue0.52567746
131MP0004215_abnormal_myocardial_fiber0.51537231
132MP0005623_abnormal_meninges_morphology0.50844226
133MP0000534_abnormal_ureter_morphology0.48038329
134MP0008961_abnormal_basal_metabolism0.47548801
135MP0003861_abnormal_nervous_system0.47466737
136MP0010769_abnormal_survival0.47174849
137MP0010770_preweaning_lethality0.46321832
138MP0002082_postnatal_lethality0.46321832
139MP0005187_abnormal_penis_morphology0.45402695

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.58597867
2Myokymia (HP:0002411)7.07884419
3Focal seizures (HP:0007359)5.78190821
4Action tremor (HP:0002345)4.52424256
5Epileptic encephalopathy (HP:0200134)4.51939516
6Visual hallucinations (HP:0002367)4.47872042
7Febrile seizures (HP:0002373)4.39971809
8Atonic seizures (HP:0010819)4.10596187
9Absence seizures (HP:0002121)4.03391872
10Progressive cerebellar ataxia (HP:0002073)4.00971007
11Scanning speech (HP:0002168)3.76037132
12Dialeptic seizures (HP:0011146)3.74949230
13Generalized tonic-clonic seizures (HP:0002069)3.67101940
14Ankle clonus (HP:0011448)3.63229354
15Supranuclear gaze palsy (HP:0000605)3.57259303
16Sudden death (HP:0001699)3.44885514
17Poor eye contact (HP:0000817)3.41073067
18Gaze-evoked nystagmus (HP:0000640)3.36999413
19Broad-based gait (HP:0002136)3.33057641
20Abnormality of the ischium (HP:0003174)3.26050346
21Truncal ataxia (HP:0002078)3.24379242
22Vitreoretinal degeneration (HP:0000655)3.23440627
23Urinary bladder sphincter dysfunction (HP:0002839)3.14095754
24Hyperventilation (HP:0002883)3.11592711
25Dysdiadochokinesis (HP:0002075)3.09413138
26Papillary thyroid carcinoma (HP:0002895)3.08199412
27Neoplasm of the peripheral nervous system (HP:0100007)3.05526004
28Impaired social interactions (HP:0000735)3.04472304
29Abnormal social behavior (HP:0012433)3.04472304
30Depression (HP:0000716)3.03936328
31Impaired vibration sensation in the lower limbs (HP:0002166)3.02756597
32Right ventricular cardiomyopathy (HP:0011663)3.01195395
33Dysmetria (HP:0001310)2.98222557
34Calf muscle hypertrophy (HP:0008981)2.92239957
35Amblyopia (HP:0000646)2.89683401
36Thickened helices (HP:0000391)2.87332742
37Urinary urgency (HP:0000012)2.86364836
38Thyroid carcinoma (HP:0002890)2.80185656
39Abnormality of the lower motor neuron (HP:0002366)2.75283180
40Anxiety (HP:0000739)2.74842700
41Insidious onset (HP:0003587)2.74409643
42Termporal pattern (HP:0011008)2.74409643
43Torticollis (HP:0000473)2.72578238
44Excessive salivation (HP:0003781)2.69106611
45Drooling (HP:0002307)2.69106611
46Cerebellar dysplasia (HP:0007033)2.67971200
47Impaired smooth pursuit (HP:0007772)2.67435226
48Postural instability (HP:0002172)2.66966513
49Spastic gait (HP:0002064)2.65551331
50Intention tremor (HP:0002080)2.64319510
51Chorioretinal atrophy (HP:0000533)2.60882346
52Abnormality of the calf musculature (HP:0001430)2.59990760
53Epileptiform EEG discharges (HP:0011182)2.58783934
54Partial duplication of the phalanx of hand (HP:0009999)2.55840300
55Coronal craniosynostosis (HP:0004440)2.54274455
56Ventricular tachycardia (HP:0004756)2.53551054
57Myelomeningocele (HP:0002475)2.52043497
58Abnormal eating behavior (HP:0100738)2.52000097
59Pheochromocytoma (HP:0002666)2.50515194
60Dysmetric saccades (HP:0000641)2.49262117
61EEG with generalized epileptiform discharges (HP:0011198)2.45134205
62Muscle hypertrophy of the lower extremities (HP:0008968)2.43430416
63Syncope (HP:0001279)2.42720790
64Genetic anticipation (HP:0003743)2.42495756
65Retinal atrophy (HP:0001105)2.41946102
66Megalencephaly (HP:0001355)2.41677711
67Abnormality of the corticospinal tract (HP:0002492)2.39652875
68Bell-shaped thorax (HP:0001591)2.38953399
69Bundle branch block (HP:0011710)2.38900615
70Mutism (HP:0002300)2.38121376
71Protruding tongue (HP:0010808)2.37513073
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.35474045
73Focal dystonia (HP:0004373)2.35377501
74Atrial fibrillation (HP:0005110)2.32381860
75Stereotypic behavior (HP:0000733)2.30585930
76Papilledema (HP:0001085)2.27562193
77Aplasia involving bones of the upper limbs (HP:0009823)2.27039623
78Aplasia of the phalanges of the hand (HP:0009802)2.27039623
79Aplasia involving bones of the extremities (HP:0009825)2.27039623
80Prolonged QT interval (HP:0001657)2.25162609
81Hypsarrhythmia (HP:0002521)2.23930015
82Hemiparesis (HP:0001269)2.23030038
83Neurofibrillary tangles (HP:0002185)2.22227824
84Thyroid-stimulating hormone excess (HP:0002925)2.21675528
85Lower limb muscle weakness (HP:0007340)2.21431924
86Craniofacial dystonia (HP:0012179)2.21296329
87Abnormality of ocular smooth pursuit (HP:0000617)2.20508948
88Ulnar claw (HP:0001178)2.19984057
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19536110
90Partial duplication of thumb phalanx (HP:0009944)2.19081022
91Aqueductal stenosis (HP:0002410)2.18609909
92Abnormality of the lumbar spine (HP:0100712)2.17882063
93Arterial tortuosity (HP:0005116)2.15394984
94Mild short stature (HP:0003502)2.14512299
95Annular pancreas (HP:0001734)2.13977838
96Primary atrial arrhythmia (HP:0001692)2.13788222
97Neoplasm of the small intestine (HP:0100833)2.13621764
98Neuroendocrine neoplasm (HP:0100634)2.12889169
99Absent speech (HP:0001344)2.12135980
100Goiter (HP:0000853)2.11670717
101Impaired vibratory sensation (HP:0002495)2.11589047
102Abnormal EKG (HP:0003115)2.11405472
103Fetal akinesia sequence (HP:0001989)2.11126423
104Volvulus (HP:0002580)2.10573085
105Cerebral inclusion bodies (HP:0100314)2.09847174
106Cupped ear (HP:0000378)2.08321620
107Impaired pain sensation (HP:0007328)2.07710168
108Abnormality of pain sensation (HP:0010832)2.07710168
109Bradykinesia (HP:0002067)2.07511918
110Hammertoe (HP:0001765)2.05970182
111Abnormality of incisor morphology (HP:0011063)2.04987352
112Pointed chin (HP:0000307)2.04504047
113Gait imbalance (HP:0002141)2.02931324
114Bifid tongue (HP:0010297)2.02113561
115Preaxial foot polydactyly (HP:0001841)2.01114464
116Ventricular fibrillation (HP:0001663)2.00518380
117Vascular tortuosity (HP:0004948)1.99085770
118Blue irides (HP:0000635)1.98946078
119Supraventricular tachycardia (HP:0004755)1.98090488
120Pulmonary artery stenosis (HP:0004415)1.97893719
121Lower limb amyotrophy (HP:0007210)1.97880554
122Supraventricular arrhythmia (HP:0005115)1.96858041
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.94497010
124Bradycardia (HP:0001662)1.93415812
125Abnormality of binocular vision (HP:0011514)1.92722838
126Diplopia (HP:0000651)1.92722838
127Decreased lacrimation (HP:0000633)1.91705445
128Rimmed vacuoles (HP:0003805)1.91112453
129Limb dystonia (HP:0002451)1.91060499
130Overgrowth (HP:0001548)1.90806862
131Alacrima (HP:0000522)1.90378909
132Hemiplegia (HP:0002301)1.90333464
133Progressive inability to walk (HP:0002505)1.90236021
134Onion bulb formation (HP:0003383)1.89405218
135Specific learning disability (HP:0001328)1.89258855
136Clonus (HP:0002169)1.88961885
137Incomplete penetrance (HP:0003829)1.88302554
138Pulmonic stenosis (HP:0001642)1.88268711
139Generalized myoclonic seizures (HP:0002123)1.87684307
140Vertebral arch anomaly (HP:0008438)1.87679278
141Abnormality of saccadic eye movements (HP:0000570)1.87191359
142Resting tremor (HP:0002322)1.86049168
143Cutaneous finger syndactyly (HP:0010554)1.85555812
144Abnormality of cochlea (HP:0000375)1.83946561
145Abnormality of salivation (HP:0100755)1.83333003
146Lower limb asymmetry (HP:0100559)1.81855286
147Neoplasm of head and neck (HP:0012288)1.81477340
148Esophageal neoplasm (HP:0100751)1.81477340
149Inability to walk (HP:0002540)1.80568572
150Status epilepticus (HP:0002133)1.80137712
151Limited hip movement (HP:0008800)1.79272044
152Congenital sensorineural hearing impairment (HP:0008527)1.78111015
153Inappropriate behavior (HP:0000719)1.78056390
154Ankyloglossia (HP:0010296)1.77989503
155Agitation (HP:0000713)1.77985967
156Insomnia (HP:0100785)1.76467797
157Long nose (HP:0003189)1.75858609
158Periauricular skin pits (HP:0100277)1.75342112
159Preauricular pit (HP:0004467)1.75342112
160Widely spaced teeth (HP:0000687)1.71473870
161Neoplasm of the rectum (HP:0100743)1.69495865
162Hypoplastic ischia (HP:0003175)1.67358787
163Short tibia (HP:0005736)1.66087228
164Hepatoblastoma (HP:0002884)1.65647675
165Genital tract atresia (HP:0001827)1.64329700
166Spondylolisthesis (HP:0003302)1.63710409
167Large earlobe (HP:0009748)1.63052414
168Abnormality of the periventricular white matter (HP:0002518)1.62601622
169Deeply set eye (HP:0000490)1.62549891
170Midline defect of the nose (HP:0004122)1.62514236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.10131189
2EPHA45.26267615
3PKN25.21007049
4NTRK34.59427975
5MAP3K93.70038351
6FLT33.16989762
7MARK12.90257451
8KSR22.84797135
9PDGFRA2.78602224
10RIPK42.66887675
11NTRK12.53950269
12MINK12.49452094
13MAP3K42.47404581
14LMTK22.47177251
15DAPK22.35028425
16STK38L2.27350567
17PAK62.15196980
18NTRK22.11361929
19KSR12.03350243
20MAP2K71.92494896
21PRKD31.82714032
22MAP3K21.74219762
23CCNB11.70784001
24CASK1.64292605
25TNIK1.54857875
26PIK3CA1.53405084
27CAMKK11.45601008
28LATS11.44283577
29CDK51.43141847
30MAP2K41.38721292
31PRPF4B1.37750222
32PDGFRB1.37689921
33DAPK11.33167802
34MAPK131.24479016
35RAF11.24382677
36SGK2231.22926016
37SGK4941.22926016
38ARAF1.21036104
39MAP3K121.15348760
40BMPR21.09949438
41SGK21.08549213
42GRK51.07886534
43CAMK2A1.07426060
44MAP3K101.07202086
45FES1.07026038
46ERBB31.04627256
47PRKCG1.04164232
48SIK21.00438784
49STK380.99798999
50PHKG20.98623729
51PHKG10.98623729
52PLK20.98239178
53GRK70.95671609
54RET0.92314339
55CAMKK20.91889412
56CAMK2B0.91351071
57ACVR1B0.89759206
58FGFR20.89037159
59TYRO30.88214605
60MAP3K130.87594592
61SGK30.85039226
62FGFR10.84619755
63TAOK10.82664505
64PAK30.82097582
65UHMK10.81752734
66CDK190.77343118
67DDR20.75885817
68MAP2K10.75623594
69CAMK10.75019097
70MAPK120.73122307
71CSNK1G20.72493851
72PRKCH0.71488850
73SGK10.71162272
74DMPK0.70167543
75MARK20.69752458
76CDK140.69171288
77CDK180.68602519
78MAP3K60.67321349
79STK110.66912884
80PBK0.66437536
81SIK30.66001111
82CDK150.64441993
83PDK10.63472815
84MAPKAPK50.63461809
85PKN10.63171743
86PDPK10.62206703
87OXSR10.61817359
88LATS20.61621127
89BMPR1B0.60729240
90PRKCZ0.59256440
91PRKCE0.58674676
92MAP3K10.58003006
93MKNK20.57995297
94NME10.57617088
95CAMK2D0.57498591
96PTK2B0.56891949
97MAP4K20.52815238
98PINK10.52549503
99CDK11A0.52069813
100FER0.51884559
101PRKG10.51738610
102FRK0.51701230
103CSNK1A1L0.51533925
104RPS6KA20.50516583
105INSRR0.50093770
106MAPK70.49625377
107RPS6KA30.49562945
108DYRK1A0.49459003
109CAMK1G0.47531362
110BCR0.45366733
111SCYL20.45228067
112FYN0.44803785
113CAMK2G0.43589544
114PNCK0.43009796
115CSNK1G10.42226101
116ALK0.42036397
117ERBB20.41104405
118CDC42BPA0.39977780
119MAPK100.39877585
120AKT30.39864440
121STK390.38250448
122CSNK1D0.37323872
123WNK10.37045271
124EPHB20.36978831
125CAMK40.35884668
126ROCK10.35062886
127PRKCB0.34913336
128CSNK1G30.34640662
129DYRK30.34009262
130WNK30.32657620
131MAP3K70.32578725
132NEK90.32256641
133PRKACA0.32093268
134MAPK40.29567085
135STK30.28842755
136MET0.27740577

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.30788528
2Olfactory transduction_Homo sapiens_hsa047402.98268344
3Synaptic vesicle cycle_Homo sapiens_hsa047212.83154220
4Circadian entrainment_Homo sapiens_hsa047132.72824354
5Glutamatergic synapse_Homo sapiens_hsa047242.59398072
6Long-term potentiation_Homo sapiens_hsa047202.56766082
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54511305
8Morphine addiction_Homo sapiens_hsa050322.52011103
9GABAergic synapse_Homo sapiens_hsa047272.51383291
10Amphetamine addiction_Homo sapiens_hsa050312.26896141
11Salivary secretion_Homo sapiens_hsa049702.20852952
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19844964
13Dopaminergic synapse_Homo sapiens_hsa047282.18018481
14Taste transduction_Homo sapiens_hsa047422.11676317
15Cholinergic synapse_Homo sapiens_hsa047252.01143463
16Insulin secretion_Homo sapiens_hsa049111.95325492
17Serotonergic synapse_Homo sapiens_hsa047261.80581395
18Gastric acid secretion_Homo sapiens_hsa049711.80524373
19Long-term depression_Homo sapiens_hsa047301.80477443
20Renin secretion_Homo sapiens_hsa049241.77276369
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76982455
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.75234679
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65783848
24Oxytocin signaling pathway_Homo sapiens_hsa049211.65091322
25Calcium signaling pathway_Homo sapiens_hsa040201.60217920
26Cocaine addiction_Homo sapiens_hsa050301.59867901
27TGF-beta signaling pathway_Homo sapiens_hsa043501.55207078
28GnRH signaling pathway_Homo sapiens_hsa049121.54019708
29ECM-receptor interaction_Homo sapiens_hsa045121.50002197
30Gap junction_Homo sapiens_hsa045401.48843521
31Hippo signaling pathway_Homo sapiens_hsa043901.46461995
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44524670
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32560295
34* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31239048
35cAMP signaling pathway_Homo sapiens_hsa040241.29310424
36Glioma_Homo sapiens_hsa052141.20567761
37Focal adhesion_Homo sapiens_hsa045101.19813275
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19255714
39Estrogen signaling pathway_Homo sapiens_hsa049151.18812484
40Type II diabetes mellitus_Homo sapiens_hsa049301.18220882
41Axon guidance_Homo sapiens_hsa043601.15776386
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14512720
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09382539
44Melanoma_Homo sapiens_hsa052181.08266988
45ErbB signaling pathway_Homo sapiens_hsa040121.07239120
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.06984222
47Dorso-ventral axis formation_Homo sapiens_hsa043201.04533082
48* Phospholipase D signaling pathway_Homo sapiens_hsa040721.04431069
49Hedgehog signaling pathway_Homo sapiens_hsa043401.03504308
50Melanogenesis_Homo sapiens_hsa049161.02756666
51Collecting duct acid secretion_Homo sapiens_hsa049661.02330013
52Phototransduction_Homo sapiens_hsa047441.00662211
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98309506
54Pancreatic secretion_Homo sapiens_hsa049720.97212062
55Adherens junction_Homo sapiens_hsa045200.92745208
56* Choline metabolism in cancer_Homo sapiens_hsa052310.92411150
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85977841
58Vibrio cholerae infection_Homo sapiens_hsa051100.84570482
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83693607
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83448022
61Basal cell carcinoma_Homo sapiens_hsa052170.76296096
62Oocyte meiosis_Homo sapiens_hsa041140.75916505
63Nitrogen metabolism_Homo sapiens_hsa009100.75560740
64Protein digestion and absorption_Homo sapiens_hsa049740.75077601
65Thyroid hormone synthesis_Homo sapiens_hsa049180.74648742
66VEGF signaling pathway_Homo sapiens_hsa043700.73796120
67Amoebiasis_Homo sapiens_hsa051460.73448109
68MAPK signaling pathway_Homo sapiens_hsa040100.73107468
69Dilated cardiomyopathy_Homo sapiens_hsa054140.72131911
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.71629160
71Cardiac muscle contraction_Homo sapiens_hsa042600.70353965
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69763729
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.69346397
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68932615
75Rap1 signaling pathway_Homo sapiens_hsa040150.68611025
76MicroRNAs in cancer_Homo sapiens_hsa052060.66754329
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65894168
78Ras signaling pathway_Homo sapiens_hsa040140.64688924
79mTOR signaling pathway_Homo sapiens_hsa041500.63520930
80Endometrial cancer_Homo sapiens_hsa052130.63046978
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59882029
82Non-small cell lung cancer_Homo sapiens_hsa052230.58566713
83Alcoholism_Homo sapiens_hsa050340.57271105
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56046309
85Inositol phosphate metabolism_Homo sapiens_hsa005620.55995311
86Proteoglycans in cancer_Homo sapiens_hsa052050.55526813
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54687150
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54166677
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53172611
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51641482
91Ovarian steroidogenesis_Homo sapiens_hsa049130.51529992
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51447521
93Pathways in cancer_Homo sapiens_hsa052000.50955713
94Endocytosis_Homo sapiens_hsa041440.50533476
95Bile secretion_Homo sapiens_hsa049760.49843865
96Glucagon signaling pathway_Homo sapiens_hsa049220.48306172
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47853826
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46007081
99Renal cell carcinoma_Homo sapiens_hsa052110.45070087
100Circadian rhythm_Homo sapiens_hsa047100.43797535
101African trypanosomiasis_Homo sapiens_hsa051430.42645249
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41959071
103Insulin signaling pathway_Homo sapiens_hsa049100.41363537
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41253944
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40477546
106Prostate cancer_Homo sapiens_hsa052150.40384246
107Platelet activation_Homo sapiens_hsa046110.40280980
108Chemokine signaling pathway_Homo sapiens_hsa040620.40102795
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38539886
110Small cell lung cancer_Homo sapiens_hsa052220.38298369
111Colorectal cancer_Homo sapiens_hsa052100.35926100
112Wnt signaling pathway_Homo sapiens_hsa043100.35872443
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35650508
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34951434
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34263021
116* Glycerophospholipid metabolism_Homo sapiens_hsa005640.34191505
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32844293
118Mineral absorption_Homo sapiens_hsa049780.32463674
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31071670
120Prion diseases_Homo sapiens_hsa050200.30386024
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.29907660
122Tight junction_Homo sapiens_hsa045300.28380450
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26770816

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