DGKK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.85909249
2plasma lipoprotein particle assembly (GO:0034377)6.49073356
3low-density lipoprotein particle remodeling (GO:0034374)6.30955045
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.23477412
5response to parathyroid hormone (GO:0071107)6.23449330
6negative regulation of fibrinolysis (GO:0051918)5.88221292
7synaptic vesicle maturation (GO:0016188)5.76697402
8regulation of bile acid biosynthetic process (GO:0070857)5.61539309
9protein-lipid complex assembly (GO:0065005)5.56145975
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51665490
11regulation of posttranscriptional gene silencing (GO:0060147)5.30695663
12regulation of gene silencing by miRNA (GO:0060964)5.30695663
13regulation of gene silencing by RNA (GO:0060966)5.30695663
14neuromuscular process controlling posture (GO:0050884)5.22616323
15regulation of apoptotic cell clearance (GO:2000425)5.19536240
16regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.15567563
17regulation of fibrinolysis (GO:0051917)5.14472693
18intestinal cholesterol absorption (GO:0030299)5.04329616
19cell migration in hindbrain (GO:0021535)4.98357999
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.96055496
21regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.85097104
22regulation of cholesterol esterification (GO:0010872)4.82290154
23macromolecular complex remodeling (GO:0034367)4.72916203
24plasma lipoprotein particle remodeling (GO:0034369)4.72916203
25protein-lipid complex remodeling (GO:0034368)4.72916203
26neurotransmitter secretion (GO:0007269)4.65866708
27protein carboxylation (GO:0018214)4.53554755
28peptidyl-glutamic acid carboxylation (GO:0017187)4.53554755
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.49919719
30plasma lipoprotein particle organization (GO:0071827)4.49402390
31cell communication by electrical coupling (GO:0010644)4.43254168
32adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.43159753
33primary amino compound metabolic process (GO:1901160)4.36114183
34synaptic vesicle exocytosis (GO:0016079)4.35376120
35regulation of synaptic vesicle exocytosis (GO:2000300)4.34526078
36embryonic retina morphogenesis in camera-type eye (GO:0060059)4.32990403
37blood coagulation, intrinsic pathway (GO:0007597)4.30396127
38regulation of protein activation cascade (GO:2000257)4.25140707
39regulation of respiratory system process (GO:0044065)4.23458708
40cholesterol efflux (GO:0033344)4.21066696
41plasma lipoprotein particle clearance (GO:0034381)4.15289593
42regulation of non-canonical Wnt signaling pathway (GO:2000050)4.14348170
43regulation of complement activation (GO:0030449)4.13248089
44regulation of respiratory gaseous exchange (GO:0043576)4.11488699
45protein-lipid complex subunit organization (GO:0071825)4.10815999
46body morphogenesis (GO:0010171)4.08897258
47neuron cell-cell adhesion (GO:0007158)4.07076080
48serotonin metabolic process (GO:0042428)4.05165336
49layer formation in cerebral cortex (GO:0021819)4.01885858
50proline transport (GO:0015824)4.00998831
51neuronal action potential propagation (GO:0019227)3.98618797
52regulation of synaptic vesicle transport (GO:1902803)3.91633146
53neurotransmitter transport (GO:0006836)3.87477906
54high-density lipoprotein particle remodeling (GO:0034375)3.84541824
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.83654829
56heterochromatin organization (GO:0070828)3.81022120
57activation of protein kinase A activity (GO:0034199)3.80016031
58glutamate secretion (GO:0014047)3.78181669
59cellular response to prostaglandin stimulus (GO:0071379)3.75520190
60regulation of transmission of nerve impulse (GO:0051969)3.63679327
61triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63632238
62regulation of neurotransmitter levels (GO:0001505)3.62009307
63vocalization behavior (GO:0071625)3.59970987
64righting reflex (GO:0060013)3.58907398
65calcium-mediated signaling using intracellular calcium source (GO:0035584)3.57439334
66locomotory exploration behavior (GO:0035641)3.56848543
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55512957
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.52836213
69regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51726009
70reverse cholesterol transport (GO:0043691)3.51586448
71respiratory system process (GO:0003016)3.50131463
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49655123
73L-phenylalanine catabolic process (GO:0006559)3.49655123
74low-density lipoprotein particle clearance (GO:0034383)3.49457508
75positive regulation of glycoprotein biosynthetic process (GO:0010560)3.49039218
76genetic imprinting (GO:0071514)3.48583506
77trivalent inorganic anion homeostasis (GO:0072506)3.44596254
78phosphate ion homeostasis (GO:0055062)3.44596254
79neurotransmitter catabolic process (GO:0042135)3.43922096
80mating behavior (GO:0007617)3.36607000
81intestinal absorption (GO:0050892)3.36365253
82response to pheromone (GO:0019236)3.36231295
83regulation of glutamate receptor signaling pathway (GO:1900449)3.34913057
84neuromuscular synaptic transmission (GO:0007274)3.34852824
85negative regulation of norepinephrine secretion (GO:0010700)3.34410382
86neurofilament cytoskeleton organization (GO:0060052)3.33868751
87cerebellar Purkinje cell differentiation (GO:0021702)3.32858913
88axon cargo transport (GO:0008088)3.32272079
89exploration behavior (GO:0035640)3.28855063
90cellular anion homeostasis (GO:0030002)3.28675757
91regulation of vesicle fusion (GO:0031338)3.27306274
92L-serine metabolic process (GO:0006563)3.23917049
93sympathetic nervous system development (GO:0048485)3.23501548
94regulation of plasminogen activation (GO:0010755)3.22239137
95regulation of cholesterol homeostasis (GO:2000188)3.19919198
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19017524
97L-phenylalanine metabolic process (GO:0006558)3.19017524
98startle response (GO:0001964)3.16370743
99neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.14859081
100positive regulation of glycoprotein metabolic process (GO:1903020)3.14552748
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.14261397
102ganglion development (GO:0061548)3.13044341
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11347761
104positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10851949
105synaptic vesicle endocytosis (GO:0048488)3.10765077
106dopamine receptor signaling pathway (GO:0007212)3.09754408
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.09189178
108protein localization to synapse (GO:0035418)3.09093352
109cell communication involved in cardiac conduction (GO:0086065)3.09092032
110cell fate commitment involved in formation of primary germ layer (GO:0060795)3.07332788
111lysine metabolic process (GO:0006553)3.06947868
112lysine catabolic process (GO:0006554)3.06947868
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06279187
114regulation of calcium ion-dependent exocytosis (GO:0017158)3.06029519
115establishment of integrated proviral latency (GO:0075713)3.05667095
116regulation of glycogen (starch) synthase activity (GO:2000465)3.05411997
117cAMP biosynthetic process (GO:0006171)3.04936755
118positive regulation of potassium ion transmembrane transport (GO:1901381)3.02874089
119response to prostaglandin (GO:0034694)3.02390709
120lung epithelium development (GO:0060428)3.01912357
121nuclear pore complex assembly (GO:0051292)3.01235514
122membrane hyperpolarization (GO:0060081)3.00803526
123cochlea development (GO:0090102)2.99846443
124response to prostaglandin E (GO:0034695)2.99606955
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99541631
126regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97485091
127sodium ion export (GO:0071436)2.96745378
128regulation of norepinephrine secretion (GO:0014061)2.94401609
129adrenergic receptor signaling pathway (GO:0071875)2.93482572
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93335485
131negative regulation of multicellular organism growth (GO:0040015)2.93295251
132neuron recognition (GO:0008038)2.91367883
133cellular response to glucagon stimulus (GO:0071377)2.91291456
134social behavior (GO:0035176)2.91262292
135intraspecies interaction between organisms (GO:0051703)2.91262292
136post-embryonic morphogenesis (GO:0009886)2.89100964
137response to phenylpropanoid (GO:0080184)2.88866608
138regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.85250992
139regulation of synaptic transmission, dopaminergic (GO:0032225)2.84659850
140lipoprotein metabolic process (GO:0042157)2.83123348
141vesicle transport along microtubule (GO:0047496)2.82786314
142cerebellar Purkinje cell layer development (GO:0021680)2.82425225
143regulation of neuronal synaptic plasticity (GO:0048168)2.82147018
144neurotransmitter-gated ion channel clustering (GO:0072578)2.81273949
145dopamine biosynthetic process (GO:0042416)2.80582564
146neuromuscular process controlling balance (GO:0050885)2.80540742
147dopaminergic neuron differentiation (GO:0071542)2.80465826
148pre-miRNA processing (GO:0031054)2.80406743
149paraxial mesoderm development (GO:0048339)2.79671169
150sterol homeostasis (GO:0055092)2.79140482
151cholesterol homeostasis (GO:0042632)2.79009253
152anterior/posterior axis specification, embryo (GO:0008595)2.78826528
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.78571258
154L-alpha-amino acid transmembrane transport (GO:1902475)2.78393657
155regulation of cholesterol biosynthetic process (GO:0045540)2.77576543
156nephron tubule morphogenesis (GO:0072078)2.77357693
157nephron epithelium morphogenesis (GO:0072088)2.77357693
158SMAD protein complex assembly (GO:0007183)2.77200928
159neurotransmitter biosynthetic process (GO:0042136)2.77095956
160negative regulation of sodium ion transport (GO:0010766)2.76403865
161neuromuscular process (GO:0050905)2.76245239
162negative regulation of sterol transport (GO:0032372)2.73732898
163negative regulation of cholesterol transport (GO:0032375)2.73732898
164DNA strand renaturation (GO:0000733)2.73444908
165IMP biosynthetic process (GO:0006188)2.73328152
166neurotransmitter metabolic process (GO:0042133)2.72329122
167axonal fasciculation (GO:0007413)2.72197334
168vitamin transmembrane transport (GO:0035461)2.71940100
169photoreceptor cell differentiation (GO:0046530)2.71824251
170eye photoreceptor cell differentiation (GO:0001754)2.71824251
171negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71095996
172regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.70936450
173ectodermal placode formation (GO:0060788)2.70622705
174response to muscle activity (GO:0014850)2.70209509
175ionotropic glutamate receptor signaling pathway (GO:0035235)2.69613251
176positive regulation of cell cycle checkpoint (GO:1901978)2.69417268
177membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68741145
178proline metabolic process (GO:0006560)2.68143255
179regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67082323
180signal release (GO:0023061)2.67022584
181negative regulation of microtubule polymerization (GO:0031115)2.66653480
182response to follicle-stimulating hormone (GO:0032354)2.64545161
183nucleotide-sugar biosynthetic process (GO:0009226)2.63435448
184cholesterol biosynthetic process (GO:0006695)2.62890130
185drinking behavior (GO:0042756)2.61385229
186serine family amino acid biosynthetic process (GO:0009070)2.61364369
187nuclear pore organization (GO:0006999)2.60365674
188serine family amino acid catabolic process (GO:0009071)2.56663074
189lipoprotein transport (GO:0042953)2.56388489
190protein localization to kinetochore (GO:0034501)2.55630949
191glycine metabolic process (GO:0006544)2.54213715
192regulation of sister chromatid cohesion (GO:0007063)2.52915961
193modified amino acid transport (GO:0072337)2.52106868
194peptidyl-glutamic acid modification (GO:0018200)2.50685296
195G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50468227
196positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.50301534
197IMP metabolic process (GO:0046040)2.49996088
198regulation of translation, ncRNA-mediated (GO:0045974)2.48988309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.29554282
2EZH2_22144423_ChIP-Seq_EOC_Human5.93321921
3E2F7_22180533_ChIP-Seq_HELA_Human5.22196888
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.07747895
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.43865269
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.32057407
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11425932
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.06767257
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01797813
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97231610
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92435633
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92435633
13AR_21909140_ChIP-Seq_LNCAP_Human2.88239683
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.84546309
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70203177
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.70095456
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.65184832
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62830324
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58836960
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53160574
21GBX2_23144817_ChIP-Seq_PC3_Human2.50735214
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45379425
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43200451
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37492600
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34854450
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32059044
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31860570
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30002884
29SOX2_18555785_ChIP-Seq_MESCs_Mouse2.27963489
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27024275
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.26160964
32REST_21632747_ChIP-Seq_MESCs_Mouse2.26088840
33RXR_22158963_ChIP-Seq_LIVER_Mouse2.26030475
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.20308501
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19120763
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17523257
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17523257
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17523257
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14530499
40SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14127183
41HNF4A_19822575_ChIP-Seq_HepG2_Human2.12142418
42BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09763536
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09459277
44RNF2_27304074_Chip-Seq_ESCs_Mouse2.09033403
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.08197729
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05938764
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.05810884
48TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01718057
49TCF4_18268006_ChIP-ChIP_LS174T_Human2.00804432
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.97853222
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96661842
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90757825
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.89990783
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88857338
55ZNF274_21170338_ChIP-Seq_K562_Hela1.81342683
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.73731837
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.73663485
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72969090
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72090762
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.70563978
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70319518
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68218641
63IGF1R_20145208_ChIP-Seq_DFB_Human1.67595267
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.66103255
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65180288
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64803058
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64495984
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64435154
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63886484
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63047881
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58210212
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.58039413
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57907331
74RNF2_27304074_Chip-Seq_NSC_Mouse1.57665696
75AR_21572438_ChIP-Seq_LNCaP_Human1.55093781
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54015625
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52916733
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50335988
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50121795
80SMAD4_21799915_ChIP-Seq_A2780_Human1.49448769
81DROSHA_22980978_ChIP-Seq_HELA_Human1.48230855
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48144138
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45755416
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.43482841
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.42930447
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39931341
87CLOCK_20551151_ChIP-Seq_293T_Human1.39739137
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38825310
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38133612
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37785424
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.36536147
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36432269
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35447129
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35331406
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33774207
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.33539876
97* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30760639
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29988898
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29364551
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28726611
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.27709250
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26672087
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.25584617
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.25497765
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25370131
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22854105
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22850721
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.21174992
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21119186
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20474187
111TAF15_26573619_Chip-Seq_HEK293_Human1.20050367
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19535955
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19107258
114* P300_19829295_ChIP-Seq_ESCs_Human1.18957359
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18956553
116SOX17_20123909_ChIP-Seq_XEN_Mouse1.18306193
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17650617
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17596670
119STAT3_23295773_ChIP-Seq_U87_Human1.17320514
120AR_25329375_ChIP-Seq_VCAP_Human1.15594379
121AR_19668381_ChIP-Seq_PC3_Human1.14135808
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13197472
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12969391
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12347915
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11601580
126NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11135291
127KDM2B_26808549_Chip-Seq_K562_Human1.10740716
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09820616
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08583911
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07452334
131SOX2_16153702_ChIP-ChIP_HESCs_Human1.06500577
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06193349
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04629944
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04606593
135TP53_20018659_ChIP-ChIP_R1E_Mouse1.03537924
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03029398
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02905015
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02673699
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02001817
140SMAD3_21741376_ChIP-Seq_ESCs_Human1.01901502
141GATA1_26923725_Chip-Seq_HPCs_Mouse1.01816907
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01443752
143DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00479973
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00054976
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99681498
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99370255
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.98961069
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98565408
149* RUNX2_22187159_ChIP-Seq_PCA_Human0.98533641
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97633711
151FUS_26573619_Chip-Seq_HEK293_Human0.97501581
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95505388
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.94494374
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.94124162
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93708703
156ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92546168
157OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92347237
158MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92047816
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92008017
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91562964
161TCF4_23295773_ChIP-Seq_U87_Human0.91559542
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91486653
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91220264
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90818690
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90699513
166NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90513957
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.90496222
168EWS_26573619_Chip-Seq_HEK293_Human0.90372718
169KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88803887
170DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88384416
171TET1_21490601_ChIP-Seq_MESCs_Mouse0.88370643
172IRF1_19129219_ChIP-ChIP_H3396_Human0.87773981
173* JUN_21703547_ChIP-Seq_K562_Human0.87682275
174POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87629420
175ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87477399
176POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86906682
177E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86712741
178PRDM14_20953172_ChIP-Seq_ESCs_Human0.84955718
179DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82773637
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82171299
181TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80673299
182NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79610405
183KAP1_27257070_Chip-Seq_ESCs_Mouse0.78102159
184CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77844725
185CREB1_15753290_ChIP-ChIP_HEK293T_Human0.77773836
186SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77282370
187FOXO3_23340844_ChIP-Seq_DLD1_Human0.76339248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.84432980
2MP0003123_paternal_imprinting5.80806286
3MP0003787_abnormal_imprinting4.89752960
4MP0003941_abnormal_skin_development4.04656043
5MP0003121_genomic_imprinting3.92527516
6MP0005645_abnormal_hypothalamus_physiol3.90676543
7MP0003195_calcinosis3.45965092
8MP0008877_abnormal_DNA_methylation3.28989613
9MP0004859_abnormal_synaptic_plasticity3.28732197
10MP0006276_abnormal_autonomic_nervous3.08737489
11MP0005365_abnormal_bile_salt3.05999708
12MP0009046_muscle_twitch2.79959234
13MP0002139_abnormal_hepatobiliary_system2.79075486
14MP0003890_abnormal_embryonic-extraembry2.78210197
15MP0002638_abnormal_pupillary_reflex2.71248118
16MP0003567_abnormal_fetal_cardiomyocyte2.68812094
17MP0003635_abnormal_synaptic_transmissio2.63693225
18MP0003880_abnormal_central_pattern2.53069409
19MP0001666_abnormal_nutrient_absorption2.44660272
20MP0005423_abnormal_somatic_nervous2.42804705
21MP0001968_abnormal_touch/_nociception2.34763681
22MP0005360_urolithiasis2.32972063
23MP0010329_abnormal_lipoprotein_level2.23435599
24MP0005085_abnormal_gallbladder_physiolo2.14822664
25MP0002089_abnormal_postnatal_growth/wei2.14407233
26MP0009745_abnormal_behavioral_response2.12214874
27MP0003111_abnormal_nucleus_morphology2.11384274
28MP0004957_abnormal_blastocyst_morpholog2.08568600
29MP0003693_abnormal_embryo_hatching2.07241639
30MP0001293_anophthalmia2.02127662
31MP0002063_abnormal_learning/memory/cond1.92363336
32MP0005408_hypopigmentation1.91493174
33MP0006292_abnormal_olfactory_placode1.90546171
34MP0002064_seizures1.89721691
35MP0002572_abnormal_emotion/affect_behav1.87657972
36MP0002254_reproductive_system_inflammat1.86809076
37MP0001501_abnormal_sleep_pattern1.84343459
38MP0000566_synostosis1.82397104
39MP0003136_yellow_coat_color1.79999590
40MP0002733_abnormal_thermal_nociception1.76525607
41MP0004270_analgesia1.76398271
42MP0001730_embryonic_growth_arrest1.75675913
43MP0004142_abnormal_muscle_tone1.75181640
44MP0002184_abnormal_innervation1.68274309
45MP0002272_abnormal_nervous_system1.64799466
46MP0001915_intracranial_hemorrhage1.64329541
47MP0002734_abnormal_mechanical_nocicepti1.62602283
48MP0005623_abnormal_meninges_morphology1.62275465
49MP0002697_abnormal_eye_size1.60463962
50MP0002557_abnormal_social/conspecific_i1.54460731
51MP0002909_abnormal_adrenal_gland1.48899010
52MP0001286_abnormal_eye_development1.43257564
53MP0003718_maternal_effect1.39161674
54MP0010094_abnormal_chromosome_stability1.37857680
55MP0002067_abnormal_sensory_capabilities1.37823597
56MP0001486_abnormal_startle_reflex1.37007447
57MP0001905_abnormal_dopamine_level1.35518233
58MP0008875_abnormal_xenobiotic_pharmacok1.35406189
59MP0010368_abnormal_lymphatic_system1.35386023
60MP0002938_white_spotting1.33594024
61MP0008932_abnormal_embryonic_tissue1.31593305
62MP0000955_abnormal_spinal_cord1.31011913
63MP0005410_abnormal_fertilization1.29311402
64MP0004924_abnormal_behavior1.26594785
65MP0005386_behavior/neurological_phenoty1.26594785
66MP0001970_abnormal_pain_threshold1.26339183
67MP0003878_abnormal_ear_physiology1.25855259
68MP0005377_hearing/vestibular/ear_phenot1.25855259
69MP0005084_abnormal_gallbladder_morpholo1.25772648
70MP0000778_abnormal_nervous_system1.25150346
71MP0004264_abnormal_extraembryonic_tissu1.22555924
72MP0004811_abnormal_neuron_physiology1.22347929
73MP0004085_abnormal_heartbeat1.21911749
74MP0002736_abnormal_nociception_after1.21603144
75MP0005380_embryogenesis_phenotype1.19495294
76MP0001672_abnormal_embryogenesis/_devel1.19495294
77MP0002132_abnormal_respiratory_system1.18211130
78MP0009697_abnormal_copulation1.18147022
79MP0008007_abnormal_cellular_replicative1.16578179
80MP0003942_abnormal_urinary_system1.16002186
81MP0003868_abnormal_feces_composition1.14233334
82MP0000751_myopathy1.13798866
83MP0002735_abnormal_chemical_nociception1.13602853
84MP0002233_abnormal_nose_morphology1.11109836
85MP0004145_abnormal_muscle_electrophysio1.10173595
86MP0003943_abnormal_hepatobiliary_system1.09517929
87MP0003119_abnormal_digestive_system1.07866630
88MP0006054_spinal_hemorrhage1.07615608
89MP0001697_abnormal_embryo_size1.07476098
90MP0002882_abnormal_neuron_morphology1.07002027
91MP0003984_embryonic_growth_retardation1.04915726
92MP0001324_abnormal_eye_pigmentation1.03501594
93MP0002088_abnormal_embryonic_growth/wei1.02311912
94MP0003172_abnormal_lysosome_physiology1.02266984
95MP0003252_abnormal_bile_duct1.01408878
96MP0005646_abnormal_pituitary_gland1.00458312
97MP0002066_abnormal_motor_capabilities/c0.99688034
98MP0002933_joint_inflammation0.98980154
99MP0002084_abnormal_developmental_patter0.98840914
100MP0002086_abnormal_extraembryonic_tissu0.98439766
101MP0002085_abnormal_embryonic_tissue0.97297189
102MP0002152_abnormal_brain_morphology0.97140798
103MP0002751_abnormal_autonomic_nervous0.97073787
104MP0004185_abnormal_adipocyte_glucose0.97022046
105MP0001440_abnormal_grooming_behavior0.96803533
106MP0003077_abnormal_cell_cycle0.96634917
107MP0003115_abnormal_respiratory_system0.95571811
108MP0002160_abnormal_reproductive_system0.95416530
109MP0000631_abnormal_neuroendocrine_gland0.94762731
110MP0006035_abnormal_mitochondrial_morpho0.93780718
111MP0002092_abnormal_eye_morphology0.93485354
112MP0002080_prenatal_lethality0.92182878
113MP0003959_abnormal_lean_body0.92091450
114MP0001188_hyperpigmentation0.90986798
115MP0001529_abnormal_vocalization0.90613621
116MP0001502_abnormal_circadian_rhythm0.90512150
117MP0008058_abnormal_DNA_repair0.90427864
118MP0010386_abnormal_urinary_bladder0.90210719
119MP0002163_abnormal_gland_morphology0.88538215
120MP0004084_abnormal_cardiac_muscle0.86796677
121MP0003566_abnormal_cell_adhesion0.85650930
122MP0004233_abnormal_muscle_weight0.85511726
123MP0003385_abnormal_body_wall0.84755637
124MP0001299_abnormal_eye_distance/0.84672229
125MP0001348_abnormal_lacrimal_gland0.84040961
126MP0005076_abnormal_cell_differentiation0.82921912
127MP0001727_abnormal_embryo_implantation0.81763859
128MP0000537_abnormal_urethra_morphology0.81510828
129MP0005257_abnormal_intraocular_pressure0.80903875
130MP0005451_abnormal_body_composition0.80511489
131MP0003861_abnormal_nervous_system0.79989653
132MP0000003_abnormal_adipose_tissue0.79409308
133MP0009672_abnormal_birth_weight0.78549563
134MP0000534_abnormal_ureter_morphology0.77670320
135MP0005379_endocrine/exocrine_gland_phen0.77399761
136MP0006138_congestive_heart_failure0.77041819
137MP0002752_abnormal_somatic_nervous0.77005087
138MP0001943_abnormal_respiration0.76964350
139MP0008260_abnormal_autophagy0.76231496
140MP0003948_abnormal_gas_homeostasis0.75068051
141MP0000609_abnormal_liver_physiology0.74911573
142MP0000569_abnormal_digit_pigmentation0.73436409
143MP0003698_abnormal_male_reproductive0.72880354
144MP0001929_abnormal_gametogenesis0.72863602
145MP0005391_vision/eye_phenotype0.72475280
146MP0002118_abnormal_lipid_homeostasis0.70254068
147MP0000538_abnormal_urinary_bladder0.70094649
148MP0002127_abnormal_cardiovascular_syste0.69601528
149MP0004197_abnormal_fetal_growth/weight/0.69105466
150MP0000230_abnormal_systemic_arterial0.68780586
151MP0002161_abnormal_fertility/fecundity0.68596769
152MP0003011_delayed_dark_adaptation0.67724342
153MP0005332_abnormal_amino_acid0.67582500
154MP0001661_extended_life_span0.67542786
155MP0004019_abnormal_vitamin_homeostasis0.66161860
156MP0004036_abnormal_muscle_relaxation0.65330260
157MP0005551_abnormal_eye_electrophysiolog0.64645787
158MP0001270_distended_abdomen0.64524649
159MP0005187_abnormal_penis_morphology0.63759127
160MP0009384_cardiac_valve_regurgitation0.63525312
161MP0000653_abnormal_sex_gland0.63277700
162MP0002269_muscular_atrophy0.62825554
163MP0004130_abnormal_muscle_cell0.62453726
164MP0000598_abnormal_liver_morphology0.62438985
165MP0003937_abnormal_limbs/digits/tail_de0.61961285
166MP0008569_lethality_at_weaning0.61077195
167MP0001145_abnormal_male_reproductive0.60909650
168MP0004133_heterotaxia0.60674642
169MP0010770_preweaning_lethality0.60178314
170MP0002082_postnatal_lethality0.60178314
171MP0002972_abnormal_cardiac_muscle0.59742660
172MP0000639_abnormal_adrenal_gland0.58865418
173MP0009703_decreased_birth_body0.58821121
174MP0004858_abnormal_nervous_system0.58172236
175MP0010769_abnormal_survival0.57649323
176MP0002332_abnormal_exercise_endurance0.57568604
177MP0002069_abnormal_eating/drinking_beha0.57433650
178MP0009780_abnormal_chondrocyte_physiolo0.53934814
179MP0002081_perinatal_lethality0.53658978
180MP0010768_mortality/aging0.53604334
181MP0004272_abnormal_basement_membrane0.53342757
182MP0004885_abnormal_endolymph0.52842098
183MP0003638_abnormal_response/metabolism_0.52129497
184MP0003137_abnormal_impulse_conducting0.50888799
185MP0009250_abnormal_appendicular_skeleto0.49307451
186MP0001986_abnormal_taste_sensitivity0.49050283
187MP0003315_abnormal_perineum_morphology0.48559232

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.65737262
2Prolonged partial thromboplastin time (HP:0003645)5.95928478
3Agitation (HP:0000713)5.54173945
4Hypobetalipoproteinemia (HP:0003563)5.36564988
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.36240378
6Hepatoblastoma (HP:0002884)5.27673539
7Enlarged penis (HP:0000040)5.27038420
8Menstrual irregularities (HP:0000858)4.91002239
9Hypercortisolism (HP:0001578)4.74125514
10Hyperthyroidism (HP:0000836)4.71745826
11Macroorchidism (HP:0000053)4.42675500
12Myokymia (HP:0002411)4.38153894
13Abnormality of the common coagulation pathway (HP:0010990)4.29192739
14Acanthocytosis (HP:0001927)4.20945656
15Small epiphyses (HP:0010585)4.12842618
16Joint hemorrhage (HP:0005261)4.11324461
17Pancreatic islet-cell hyperplasia (HP:0004510)4.11164053
18Broad alveolar ridges (HP:0000187)3.84190593
19Limb dystonia (HP:0002451)3.73740580
20Recurrent gram-negative bacterial infections (HP:0005420)3.67693494
21Malnutrition (HP:0004395)3.66340799
22Nephroblastoma (Wilms tumor) (HP:0002667)3.62980092
23Testicular neoplasm (HP:0010788)3.48060691
24Abnormality of calcium-phosphate metabolism (HP:0100530)3.41429610
25Embryonal renal neoplasm (HP:0011794)3.35014856
26Hypercholesterolemia (HP:0003124)3.32889776
27Spontaneous abortion (HP:0005268)3.30246568
28Hypoventilation (HP:0002791)3.26883953
29Complement deficiency (HP:0004431)3.21881789
30Hyperglycinemia (HP:0002154)3.20813787
31Diastasis recti (HP:0001540)3.19004888
32Focal seizures (HP:0007359)3.18573896
33Hypolipoproteinemia (HP:0010981)3.17441328
34Visual hallucinations (HP:0002367)3.09652676
35Supranuclear gaze palsy (HP:0000605)3.08734610
36Restlessness (HP:0000711)3.07730775
37Depression (HP:0000716)3.06147117
38Pheochromocytoma (HP:0002666)3.05327500
39Growth hormone excess (HP:0000845)3.02683513
40Anxiety (HP:0000739)2.98716079
41Hypophosphatemic rickets (HP:0004912)2.97804087
42Abnormality of carpal bone ossification (HP:0006257)2.97700561
43Hypoglycemic coma (HP:0001325)2.97470415
44Failure to thrive in infancy (HP:0001531)2.96761305
45Ankle clonus (HP:0011448)2.95487356
46Progressive cerebellar ataxia (HP:0002073)2.93497177
47Hyperparathyroidism (HP:0000843)2.93480569
48Hypoglycemic seizures (HP:0002173)2.87966873
49Rhinitis (HP:0012384)2.87430657
50Hypokinesia (HP:0002375)2.86159266
51Nasal speech (HP:0001611)2.85172050
52Poor suck (HP:0002033)2.84772576
53Vaginal fistula (HP:0004320)2.82931630
54Generalized tonic-clonic seizures (HP:0002069)2.82519889
55Epiphyseal dysplasia (HP:0002656)2.82054065
56Striae distensae (HP:0001065)2.81285192
57Irregular epiphyses (HP:0010582)2.80945785
58Action tremor (HP:0002345)2.80859706
59Supernumerary spleens (HP:0009799)2.80248837
60Menorrhagia (HP:0000132)2.77695182
61Myelomeningocele (HP:0002475)2.70655669
62Glomerulonephritis (HP:0000099)2.67326300
63Broad palm (HP:0001169)2.65009360
64Abnormality of the lacrimal duct (HP:0011481)2.61869786
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60587702
66Osteomalacia (HP:0002749)2.59045515
67Focal motor seizures (HP:0011153)2.58683916
68Epidermoid cyst (HP:0200040)2.58112849
69Abnormality of the pancreatic islet cells (HP:0006476)2.57072690
70Abnormality of endocrine pancreas physiology (HP:0012093)2.57072690
71Urinary bladder sphincter dysfunction (HP:0002839)2.55207677
72Neuroendocrine neoplasm (HP:0100634)2.55098216
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54021169
74Abnormal tarsal ossification (HP:0008369)2.53567520
75Wide nose (HP:0000445)2.51827513
76Xanthomatosis (HP:0000991)2.51479913
77Adrenal overactivity (HP:0002717)2.50719316
78Papilledema (HP:0001085)2.50498086
79Meckel diverticulum (HP:0002245)2.48245820
80Embryonal neoplasm (HP:0002898)2.46791462
81Absence seizures (HP:0002121)2.42929604
82Absent eyebrow (HP:0002223)2.41795815
83Hyperphosphatemia (HP:0002905)2.41564482
84Intrahepatic cholestasis (HP:0001406)2.40494957
85Mutism (HP:0002300)2.38010924
86Abnormality of serine family amino acid metabolism (HP:0010894)2.37169853
87Abnormality of glycine metabolism (HP:0010895)2.37169853
88Ventricular fibrillation (HP:0001663)2.35580884
89Abnormality of the ileum (HP:0001549)2.32893674
90Rectovaginal fistula (HP:0000143)2.31949642
91Rectal fistula (HP:0100590)2.31949642
92Abnormality of the nasal septum (HP:0000419)2.31937993
93Polyphagia (HP:0002591)2.31199945
94Abnormality of the lumbar spine (HP:0100712)2.30695601
95Diminished movement (HP:0002374)2.30336229
96Genetic anticipation (HP:0003743)2.29587181
97Amblyopia (HP:0000646)2.22572213
98Enlarged kidneys (HP:0000105)2.21150000
99Cupped ribs (HP:0000887)2.21098296
100Abnormal lung lobation (HP:0002101)2.20711856
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.20232828
102Absent epiphyses (HP:0010577)2.20232828
103Abnormal hand bone ossification (HP:0010660)2.19722415
104Alacrima (HP:0000522)2.19567343
105Choanal stenosis (HP:0000452)2.18952981
106Increased serum pyruvate (HP:0003542)2.18507194
107Abnormality of the alveolar ridges (HP:0006477)2.18398038
108Abnormality of the labia minora (HP:0012880)2.18198760
109Atonic seizures (HP:0010819)2.18068936
110Abnormal ossification of hand bones (HP:0005921)2.16996909
111Postural instability (HP:0002172)2.16696850
112Facial shape deformation (HP:0011334)2.16254840
113Potter facies (HP:0002009)2.16254840
114Psychosis (HP:0000709)2.14376953
115Intestinal polyposis (HP:0200008)2.14259871
116Thrombophlebitis (HP:0004418)2.13804223
117Aplasia/Hypoplasia of the sternum (HP:0006714)2.12914394
118Cranial hyperostosis (HP:0004437)2.12455183
119Abnormality of cochlea (HP:0000375)2.12412871
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09652257
121Abnormality of the pubic bones (HP:0003172)2.09035641
122Bilateral microphthalmos (HP:0007633)2.07451146
123Abnormality of the nasolacrimal system (HP:0000614)2.07025890
124Vascular calcification (HP:0004934)2.06912260
125Chronic bronchitis (HP:0004469)2.06887000
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06724648
127Intestinal fistula (HP:0100819)2.06232762
128Neoplasm of the liver (HP:0002896)2.06136909
129Truncal ataxia (HP:0002078)2.05081549
130Abnormality of the corticospinal tract (HP:0002492)2.04208209
131Hyperglycinuria (HP:0003108)2.01505071
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00352657
133Left ventricular hypertrophy (HP:0001712)2.00069038
134Intestinal polyp (HP:0005266)1.99315562
135Anophthalmia (HP:0000528)1.98791893
136Prenatal maternal abnormality (HP:0002686)1.98662195
137Abnormal eating behavior (HP:0100738)1.97959947
138Urinary urgency (HP:0000012)1.97864598
139Asymmetry of the thorax (HP:0001555)1.97484489
140Abnormality of complement system (HP:0005339)1.96829499
141Termporal pattern (HP:0011008)1.96382576
142Insidious onset (HP:0003587)1.96382576
143Aqueductal stenosis (HP:0002410)1.96005918
144Hyperinsulinemic hypoglycemia (HP:0000825)1.94866016
145Hemorrhage of the eye (HP:0011885)1.94047329
146Neoplasm of the peripheral nervous system (HP:0100007)1.93878559
147Neoplasm of the thyroid gland (HP:0100031)1.92095248
148Flared iliac wings (HP:0002869)1.92087776
149Generalized hypotonia (HP:0001290)1.91455878
150Postural tremor (HP:0002174)1.89729817
151Febrile seizures (HP:0002373)1.89087931
152Anal stenosis (HP:0002025)1.88810976
153Abnormality of glycolysis (HP:0004366)1.88516674
154Goiter (HP:0000853)1.88316408
155Abnormality of pain sensation (HP:0010832)1.87618905
156Impaired pain sensation (HP:0007328)1.87618905
157Bifid tongue (HP:0010297)1.86902669
158Abnormality of the wing of the ilium (HP:0011867)1.86498079
159Sacral dimple (HP:0000960)1.85257218
160Excessive salivation (HP:0003781)1.83830985
161Drooling (HP:0002307)1.83830985
162Capillary hemangiomas (HP:0005306)1.83199724
163Cholecystitis (HP:0001082)1.82702046
164Abnormal gallbladder physiology (HP:0012438)1.82702046
165Scrotal hypoplasia (HP:0000046)1.82321237
166Short metatarsal (HP:0010743)1.81053321
167Exotropia (HP:0000577)1.80117141
168Limited elbow extension (HP:0001377)1.79525353
169Absent speech (HP:0001344)1.79501085
170Dialeptic seizures (HP:0011146)1.79428395
171Progressive inability to walk (HP:0002505)1.79425851
172Gonadal dysgenesis (HP:0000133)1.78986770
173Truncal obesity (HP:0001956)1.78760426
174Rickets (HP:0002748)1.78195279
175Midline defect of the nose (HP:0004122)1.78172897
176Trigonocephaly (HP:0000243)1.78086994
177Renal duplication (HP:0000075)1.78023308
178Papillary thyroid carcinoma (HP:0002895)1.77976876
179Epileptic encephalopathy (HP:0200134)1.77863542
180Precocious puberty (HP:0000826)1.77028225
181Supernumerary ribs (HP:0005815)1.76758161
182Akinesia (HP:0002304)1.76665399
183Lower limb muscle weakness (HP:0007340)1.74849514
184Impaired vibration sensation in the lower limbs (HP:0002166)1.73988510
185Poor eye contact (HP:0000817)1.72682561
186Peripheral hypomyelination (HP:0007182)1.72387729
187Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.72110158
188Torticollis (HP:0000473)1.69581322
189Vertebral arch anomaly (HP:0008438)1.68651208
190Osteopenia (HP:0000938)1.67941925
191Neuroblastoma (HP:0003006)1.66740238
192Primitive neuroectodermal tumor (HP:0030065)1.66740238
193Neuroblastic tumors (HP:0004376)1.66740238
194Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.66740238
195Frequent falls (HP:0002359)1.66282478
196Impaired social interactions (HP:0000735)1.65343669
197Abnormal social behavior (HP:0012433)1.65343669
198Thickened calvaria (HP:0002684)1.64507467
199Sporadic (HP:0003745)1.64327182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.07725540
2NTRK34.98171170
3MAP3K93.77821924
4ICK3.77252883
5PBK3.70605704
6MARK13.65783755
7LATS23.43550662
8MINK13.42530167
9MAP3K43.05019561
10FGFR32.96995622
11CDK122.74103694
12PAK62.59486933
13CDC72.58088249
14TTK2.39130760
15MKNK22.27798892
16SRPK12.26329460
17MAP3K122.25845301
18NTRK22.17049521
19TNIK2.14064627
20KSR22.12858853
21PAK32.10970779
22TSSK62.06437068
23BMPR1B2.06258521
24LATS12.04901929
25FGFR22.00055526
26MAP2K41.88757999
27MKNK11.86305635
28UHMK11.83931076
29CSNK1G21.81694378
30WNK41.79263717
31CSNK1G31.71385443
32ZAK1.64995255
33MAPKAPK51.63025739
34PLK21.61857230
35MAP2K71.61476233
36BUB11.61360456
37LIMK11.59391142
38TAF11.56209504
39NEK11.54310841
40PNCK1.50365904
41MAPK131.45381936
42DYRK21.42560069
43MAP3K101.42402344
44NEK21.39866859
45GRK51.38823942
46ERBB31.31144351
47KSR11.29311923
48PHKG21.27754100
49PHKG11.27754100
50CSNK1G11.23723372
51CAMK2A1.21387359
52FGR1.19307235
53WNK31.13408652
54BRD41.11769716
55NLK1.11344583
56STK38L1.10962273
57CDC42BPA1.10507478
58BRSK21.10097343
59PLK11.09196373
60CDK71.07849568
61TYRO31.06555427
62NTRK11.05947802
63TAOK11.05927269
64CDK141.05831120
65ALK1.05806516
66CDK31.03180239
67SMG11.01793163
68PRKCG1.00458457
69CDK80.99752680
70EIF2AK10.98496067
71IRAK20.95849920
72CDK180.94910966
73PIK3CA0.94739251
74CDK150.94604560
75CAMK1D0.94304445
76CDK50.93399192
77RET0.92268732
78DYRK1B0.91226823
79LMTK20.90495861
80PRKD30.89856974
81STK380.88835777
82FER0.88750639
83PLK40.87567335
84TGFBR10.86565645
85ATM0.85533915
86PDGFRA0.84675897
87CDK11A0.81236815
88MAP3K20.79871201
89DMPK0.78773757
90OBSCN0.78647268
91VRK20.77875774
92SGK4940.77215367
93SGK2230.77215367
94CSNK1A1L0.76472666
95CAMK2G0.75669452
96ARAF0.75063788
97AKT30.73518400
98DAPK10.73436837
99ERBB20.72409320
100STK40.67739179
101NUAK10.66208865
102SCYL20.64427013
103CASK0.62920588
104STK240.61164753
105ATR0.60520917
106TESK10.60346442
107CHEK10.59960575
108VRK10.59632733
109PRKCH0.59041847
110EPHB20.58404986
111CDK10.58089526
112BRAF0.55883825
113ERBB40.55721788
114CAMK10.55686292
115CDK190.54897972
116FLT30.53356644
117DYRK30.53018003
118RAF10.52516601
119STK30.52429178
120BCR0.51712648
121CDK60.51072554
122CSNK1E0.50784778
123CSNK1D0.50508732
124CAMK2D0.49665050
125DDR20.49346846
126PLK30.49248161
127CDK40.48449933
128RPS6KA20.48449107
129CSNK2A20.47958453
130CDK20.47675105
131RPS6KB10.46255496
132EEF2K0.45244340
133PRKAA20.45087011
134ROCK10.44911605
135ADRBK10.43970788
136PRKCZ0.43281220
137STK110.42665132
138CSNK2A10.42367995
139FGFR10.42194214
140PRKDC0.42007166
141PKN20.41320659
142MAP2K10.40901255
143TIE10.40612440
144MAP3K60.40215259
145YES10.40020975
146SGK10.38796722
147EPHA40.38788507
148CAMK1G0.37286982
149PRKCB0.37036976
150NME10.36957208
151MAPK100.36822495
152WNK10.36689111
153MAP3K10.36628612
154MAP3K110.35946444
155IRAK10.35670347
156MAP3K50.35627699
157CHEK20.35247145
158BRSK10.35032631
159SGK20.33612232
160RPS6KA10.33149339
161GSK3B0.32518836
162AURKB0.31562576
163PDPK10.31224353
164PDK10.30773130
165RPS6KA30.30555578
166CAMK2B0.30437523
167SGK30.30177405
168RIPK10.26854552
169PRKG10.26306948

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.40050774
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43148647
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37154360
4Steroid biosynthesis_Homo sapiens_hsa001003.29816470
5Fat digestion and absorption_Homo sapiens_hsa049752.97771186
6Nicotine addiction_Homo sapiens_hsa050332.89980071
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.85403569
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.74227166
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.70887064
10RNA polymerase_Homo sapiens_hsa030202.66132801
11Cocaine addiction_Homo sapiens_hsa050302.65249544
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62344620
13Vitamin digestion and absorption_Homo sapiens_hsa049772.62253159
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49024197
15Serotonergic synapse_Homo sapiens_hsa047262.46340336
16Cardiac muscle contraction_Homo sapiens_hsa042602.43767696
17GABAergic synapse_Homo sapiens_hsa047272.39925681
18Amphetamine addiction_Homo sapiens_hsa050312.37398810
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30196717
20Circadian entrainment_Homo sapiens_hsa047132.10944496
21Fatty acid biosynthesis_Homo sapiens_hsa000612.09742685
22Dopaminergic synapse_Homo sapiens_hsa047282.07300984
23Morphine addiction_Homo sapiens_hsa050322.06229996
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86146344
25Parkinsons disease_Homo sapiens_hsa050121.85679733
26Insulin secretion_Homo sapiens_hsa049111.85626623
27Spliceosome_Homo sapiens_hsa030401.84701393
28Vibrio cholerae infection_Homo sapiens_hsa051101.81257045
29Oxidative phosphorylation_Homo sapiens_hsa001901.79581021
30Fatty acid metabolism_Homo sapiens_hsa012121.77786735
31Glutamatergic synapse_Homo sapiens_hsa047241.77424303
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77401542
33Taste transduction_Homo sapiens_hsa047421.77306905
34Long-term depression_Homo sapiens_hsa047301.74418997
35Cholinergic synapse_Homo sapiens_hsa047251.71872806
36Fatty acid degradation_Homo sapiens_hsa000711.71238982
37Vitamin B6 metabolism_Homo sapiens_hsa007501.69849427
38GnRH signaling pathway_Homo sapiens_hsa049121.69790124
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69469527
40Ovarian steroidogenesis_Homo sapiens_hsa049131.68066241
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66488489
42Olfactory transduction_Homo sapiens_hsa047401.64289682
43Arginine biosynthesis_Homo sapiens_hsa002201.61556272
44Salivary secretion_Homo sapiens_hsa049701.59181311
45Gap junction_Homo sapiens_hsa045401.57422407
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56174130
47Propanoate metabolism_Homo sapiens_hsa006401.55154794
48Dilated cardiomyopathy_Homo sapiens_hsa054141.55026987
49Renin secretion_Homo sapiens_hsa049241.52339782
50One carbon pool by folate_Homo sapiens_hsa006701.50722114
51Mismatch repair_Homo sapiens_hsa034301.50592271
52Biosynthesis of amino acids_Homo sapiens_hsa012301.48741029
53Staphylococcus aureus infection_Homo sapiens_hsa051501.47600255
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47369817
55Long-term potentiation_Homo sapiens_hsa047201.45442383
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44559762
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38016471
58DNA replication_Homo sapiens_hsa030301.37471435
59Melanogenesis_Homo sapiens_hsa049161.37394137
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37208782
61Arginine and proline metabolism_Homo sapiens_hsa003301.36320255
62RNA transport_Homo sapiens_hsa030131.34752522
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.33959622
64Gastric acid secretion_Homo sapiens_hsa049711.31181459
65mRNA surveillance pathway_Homo sapiens_hsa030151.31059617
66Pyruvate metabolism_Homo sapiens_hsa006201.30234459
67Collecting duct acid secretion_Homo sapiens_hsa049661.29563555
68Histidine metabolism_Homo sapiens_hsa003401.28283101
69Oxytocin signaling pathway_Homo sapiens_hsa049211.27877025
70Dorso-ventral axis formation_Homo sapiens_hsa043201.26822380
71Huntingtons disease_Homo sapiens_hsa050161.26767062
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.24426224
73Estrogen signaling pathway_Homo sapiens_hsa049151.22972290
74Oocyte meiosis_Homo sapiens_hsa041141.22514475
75Alzheimers disease_Homo sapiens_hsa050101.22129107
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21974612
77Non-homologous end-joining_Homo sapiens_hsa034501.18173493
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17070985
79Selenocompound metabolism_Homo sapiens_hsa004501.13654105
80Carbon metabolism_Homo sapiens_hsa012001.12676075
81PPAR signaling pathway_Homo sapiens_hsa033201.10864147
82N-Glycan biosynthesis_Homo sapiens_hsa005101.09100199
83Starch and sucrose metabolism_Homo sapiens_hsa005001.08308381
84Cyanoamino acid metabolism_Homo sapiens_hsa004601.06501523
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05140120
86Renin-angiotensin system_Homo sapiens_hsa046141.04671570
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04108280
88Thyroid hormone synthesis_Homo sapiens_hsa049181.00243652
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99379451
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97903982
91Adherens junction_Homo sapiens_hsa045200.97653243
92cAMP signaling pathway_Homo sapiens_hsa040240.96173255
93Phenylalanine metabolism_Homo sapiens_hsa003600.96132642
94Type II diabetes mellitus_Homo sapiens_hsa049300.95827657
95* Phospholipase D signaling pathway_Homo sapiens_hsa040720.95439218
96Fatty acid elongation_Homo sapiens_hsa000620.94897618
97Butanoate metabolism_Homo sapiens_hsa006500.93871267
98Axon guidance_Homo sapiens_hsa043600.91302326
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90796146
100* Choline metabolism in cancer_Homo sapiens_hsa052310.89911196
101Cell cycle_Homo sapiens_hsa041100.88467455
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.87927282
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87586622
104Calcium signaling pathway_Homo sapiens_hsa040200.84422121
105Glutathione metabolism_Homo sapiens_hsa004800.84395157
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82878055
107Lysine degradation_Homo sapiens_hsa003100.82129299
108Alcoholism_Homo sapiens_hsa050340.80538423
109RNA degradation_Homo sapiens_hsa030180.79768608
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79120562
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77362760
112Renal cell carcinoma_Homo sapiens_hsa052110.75408562
113Hippo signaling pathway_Homo sapiens_hsa043900.75196274
114ErbB signaling pathway_Homo sapiens_hsa040120.75130906
115Hedgehog signaling pathway_Homo sapiens_hsa043400.73762138
116Proteasome_Homo sapiens_hsa030500.71847536
117Bile secretion_Homo sapiens_hsa049760.71757222
118MAPK signaling pathway_Homo sapiens_hsa040100.71405197
119Glioma_Homo sapiens_hsa052140.71062807
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70762963
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70103972
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68800603
123Endometrial cancer_Homo sapiens_hsa052130.68212880
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67471089
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67215423
126Purine metabolism_Homo sapiens_hsa002300.66437395
127Tyrosine metabolism_Homo sapiens_hsa003500.65025212
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.64926663
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64543847
130Glucagon signaling pathway_Homo sapiens_hsa049220.63916909
131Basal transcription factors_Homo sapiens_hsa030220.63440791
132Retinol metabolism_Homo sapiens_hsa008300.63416553
133ABC transporters_Homo sapiens_hsa020100.63344155
134Wnt signaling pathway_Homo sapiens_hsa043100.61483975
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60699127
136Nitrogen metabolism_Homo sapiens_hsa009100.60590913
137Insulin signaling pathway_Homo sapiens_hsa049100.58310930
138Non-small cell lung cancer_Homo sapiens_hsa052230.57995761
139Ras signaling pathway_Homo sapiens_hsa040140.57525773
140Peroxisome_Homo sapiens_hsa041460.56198032
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55847015
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55799823
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55791524
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.55303711
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54132706
146Chemical carcinogenesis_Homo sapiens_hsa052040.53931295
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53879832
148Colorectal cancer_Homo sapiens_hsa052100.53125205
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49238983
150Rap1 signaling pathway_Homo sapiens_hsa040150.49130812
151Prion diseases_Homo sapiens_hsa050200.48298509
152beta-Alanine metabolism_Homo sapiens_hsa004100.47807216
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.47585764
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46912140
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46731062
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46554237
157Pyrimidine metabolism_Homo sapiens_hsa002400.46464527
158Type I diabetes mellitus_Homo sapiens_hsa049400.45559788
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43491944
160Base excision repair_Homo sapiens_hsa034100.43467095
161Basal cell carcinoma_Homo sapiens_hsa052170.41332872
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40713640
163Nucleotide excision repair_Homo sapiens_hsa034200.40618384
164TGF-beta signaling pathway_Homo sapiens_hsa043500.40263356
165Tight junction_Homo sapiens_hsa045300.40176653
166Protein export_Homo sapiens_hsa030600.38478781
167Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37977323
168* Metabolic pathways_Homo sapiens_hsa011000.37576605
169Thyroid cancer_Homo sapiens_hsa052160.37548637
170Platelet activation_Homo sapiens_hsa046110.37481494
171Endocytosis_Homo sapiens_hsa041440.37080644
172Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36908035
173* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36711333
174Prolactin signaling pathway_Homo sapiens_hsa049170.36073740
175Tryptophan metabolism_Homo sapiens_hsa003800.35646614
176Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34848383
177Pancreatic secretion_Homo sapiens_hsa049720.34177065
178Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31983681
179VEGF signaling pathway_Homo sapiens_hsa043700.31568298
180Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31465560
181Steroid hormone biosynthesis_Homo sapiens_hsa001400.26314695
182Pertussis_Homo sapiens_hsa051330.26122624
183Legionellosis_Homo sapiens_hsa051340.20101142
184Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19968947

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