DGKQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.20929583
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00074482
3antigen processing and presentation of endogenous antigen (GO:0019883)4.83096152
4negative regulation of cell killing (GO:0031342)4.77551718
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77551718
6negative regulation of erythrocyte differentiation (GO:0045647)4.45362590
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18849917
8mannose metabolic process (GO:0006013)4.07996143
9L-phenylalanine catabolic process (GO:0006559)4.06927513
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.06927513
11positive regulation of gamma-delta T cell activation (GO:0046645)4.06188010
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.99528371
13dicarboxylic acid biosynthetic process (GO:0043650)3.85030868
14regulation of cholesterol homeostasis (GO:2000188)3.83429702
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79003507
16L-phenylalanine metabolic process (GO:0006558)3.79003507
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66465639
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.66465639
19modulation by symbiont of host immune response (GO:0052553)3.66465639
20positive regulation by symbiont of host defense response (GO:0052509)3.66465639
21modulation by symbiont of host defense response (GO:0052031)3.66465639
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66465639
23alpha-linolenic acid metabolic process (GO:0036109)3.64907850
24drug catabolic process (GO:0042737)3.63808056
25urea cycle (GO:0000050)3.62215852
26urea metabolic process (GO:0019627)3.62215852
27macrophage activation involved in immune response (GO:0002281)3.50565796
28synaptic vesicle maturation (GO:0016188)3.50227059
29locomotory exploration behavior (GO:0035641)3.46664887
30aromatic amino acid family catabolic process (GO:0009074)3.44481939
31antigen processing and presentation via MHC class Ib (GO:0002475)3.44445626
32detection of bacterium (GO:0016045)3.44034896
33detection of other organism (GO:0098543)3.43142682
34glutamate metabolic process (GO:0006536)3.40776882
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40753755
36gamma-aminobutyric acid transport (GO:0015812)3.35013632
37positive regulation of Cdc42 GTPase activity (GO:0043089)3.34265689
38intestinal cholesterol absorption (GO:0030299)3.31237427
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30868344
40phospholipid efflux (GO:0033700)3.30323695
41leukocyte aggregation (GO:0070486)3.30304561
42high-density lipoprotein particle remodeling (GO:0034375)3.30269201
43sodium ion export (GO:0071436)3.29230253
44nitrogen cycle metabolic process (GO:0071941)3.27895091
45positive regulation of fatty acid biosynthetic process (GO:0045723)3.26490218
46negative regulation of sterol transport (GO:0032372)3.26399832
47negative regulation of cholesterol transport (GO:0032375)3.26399832
48bile acid biosynthetic process (GO:0006699)3.23913105
49neutrophil activation involved in immune response (GO:0002283)3.21208796
50kynurenine metabolic process (GO:0070189)3.17421586
51alanine transport (GO:0032328)3.16278516
52positive thymic T cell selection (GO:0045059)3.15230109
53response to peptidoglycan (GO:0032494)3.14405692
54regulation of ARF protein signal transduction (GO:0032012)3.11831594
55phospholipid homeostasis (GO:0055091)3.09696231
56exogenous drug catabolic process (GO:0042738)3.09491702
57thymic T cell selection (GO:0045061)3.09415337
58reverse cholesterol transport (GO:0043691)3.05658666
59cysteine metabolic process (GO:0006534)3.05512358
60response to muramyl dipeptide (GO:0032495)3.05469985
61homocysteine metabolic process (GO:0050667)3.05166306
62lysine metabolic process (GO:0006553)3.04960257
63lysine catabolic process (GO:0006554)3.04960257
64regulation of ARF GTPase activity (GO:0032312)3.04385213
65signal complex assembly (GO:0007172)3.02043115
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01365750
67macroautophagy (GO:0016236)3.00402677
68regulation of gamma-delta T cell activation (GO:0046643)3.00155589
69indole-containing compound catabolic process (GO:0042436)3.00009191
70indolalkylamine catabolic process (GO:0046218)3.00009191
71tryptophan catabolic process (GO:0006569)3.00009191
72regulation of leukocyte degranulation (GO:0043300)2.97880046
73cholesterol efflux (GO:0033344)2.97818224
74cellular potassium ion homeostasis (GO:0030007)2.96442623
75regulation of T-helper 2 cell differentiation (GO:0045628)2.96003958
76neurotransmitter secretion (GO:0007269)2.94811754
77bile acid metabolic process (GO:0008206)2.94527373
78regulation of interferon-beta biosynthetic process (GO:0045357)2.94286933
79regulation of bile acid biosynthetic process (GO:0070857)2.94059779
80proline transport (GO:0015824)2.93960099
81intestinal absorption (GO:0050892)2.91155355
82regulation of extracellular matrix disassembly (GO:0010715)2.90874000
83regulation of triglyceride catabolic process (GO:0010896)2.88735139
84positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88731160
85cellular modified amino acid catabolic process (GO:0042219)2.87512556
86NIK/NF-kappaB signaling (GO:0038061)2.87258338
87protein carboxylation (GO:0018214)2.87056593
88peptidyl-glutamic acid carboxylation (GO:0017187)2.87056593
89response to laminar fluid shear stress (GO:0034616)2.86638113
90sulfur amino acid catabolic process (GO:0000098)2.86513134
91regulation of cholesterol esterification (GO:0010872)2.86139166
92tryptophan metabolic process (GO:0006568)2.85598366
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83839889
94negative regulation of fibrinolysis (GO:0051918)2.83024969
95T cell selection (GO:0045058)2.82893836
96plasma lipoprotein particle assembly (GO:0034377)2.80915248
97bile acid and bile salt transport (GO:0015721)2.80634696
98glycine transport (GO:0015816)2.80439204
99glutamate secretion (GO:0014047)2.80267650
100regulation of protein activation cascade (GO:2000257)2.79470191
101glyoxylate metabolic process (GO:0046487)2.77235210
102vocalization behavior (GO:0071625)2.76930111
103detection of external biotic stimulus (GO:0098581)2.75792047
104regulation of gamma-delta T cell differentiation (GO:0045586)2.74832780
105protein-lipid complex remodeling (GO:0034368)2.74807880
106macromolecular complex remodeling (GO:0034367)2.74807880
107plasma lipoprotein particle remodeling (GO:0034369)2.74807880
108protein-lipid complex assembly (GO:0065005)2.72864081
109negative thymic T cell selection (GO:0045060)2.72294018
110complement activation, alternative pathway (GO:0006957)2.69712140
111regulation of mast cell degranulation (GO:0043304)2.69246054
112positive regulation of histone deacetylation (GO:0031065)2.67908269
113acylglycerol homeostasis (GO:0055090)2.67783960
114triglyceride homeostasis (GO:0070328)2.67783960
115protein localization to endosome (GO:0036010)2.66157695
116flavonoid metabolic process (GO:0009812)2.65964602
117positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64439248
118positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64214687
119germinal center formation (GO:0002467)2.64054869
120regulation of regulated secretory pathway (GO:1903305)2.63725613
121tyrosine metabolic process (GO:0006570)2.62579334
122negative regulation of lymphocyte mediated immunity (GO:0002707)2.61091047
123regulation of complement activation (GO:0030449)2.60213461
124positive regulation of Rap GTPase activity (GO:0032854)2.59831062
125drug transmembrane transport (GO:0006855)2.59635139
126negative regulation of leukocyte mediated immunity (GO:0002704)2.58842786
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58311648
128negative regulation of granulocyte differentiation (GO:0030853)2.57323213
129prepulse inhibition (GO:0060134)2.55762506
130B cell receptor signaling pathway (GO:0050853)2.55738884
131plasma lipoprotein particle clearance (GO:0034381)2.55735048
132positive regulation of lipid catabolic process (GO:0050996)2.55527567
133activation of Rac GTPase activity (GO:0032863)2.55306305
134cerebellar Purkinje cell differentiation (GO:0021702)2.54932726
135regulation of fibrinolysis (GO:0051917)2.54058397
136response to pheromone (GO:0019236)2.53551255
137negative T cell selection (GO:0043383)2.52850609
138immunoglobulin mediated immune response (GO:0016064)2.52459824
139response to type I interferon (GO:0034340)2.51670359
140ionotropic glutamate receptor signaling pathway (GO:0035235)2.50152910
141layer formation in cerebral cortex (GO:0021819)2.49917505
142type I interferon signaling pathway (GO:0060337)2.49706338
143cellular response to type I interferon (GO:0071357)2.49706338
144regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49486980
145cholesterol homeostasis (GO:0042632)2.49128852
146sterol homeostasis (GO:0055092)2.48020389
147lipoprotein transport (GO:0042953)2.47692654
148alpha-amino acid catabolic process (GO:1901606)2.46858418
149regulation of glutamate receptor signaling pathway (GO:1900449)2.46675747
150amino-acid betaine metabolic process (GO:0006577)2.46101697
151coenzyme catabolic process (GO:0009109)2.45296350
152ethanol oxidation (GO:0006069)2.44995479
153peptidyl-tyrosine autophosphorylation (GO:0038083)2.44991640
154fat-soluble vitamin biosynthetic process (GO:0042362)2.44857847
155phospholipid scrambling (GO:0017121)2.44706440
156regulation of B cell receptor signaling pathway (GO:0050855)2.44704546
157nucleobase catabolic process (GO:0046113)2.44558079
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44479319
159barbed-end actin filament capping (GO:0051016)2.44429829
160lipoprotein metabolic process (GO:0042157)2.44380395
161regulation of female receptivity (GO:0045924)2.44175679
162positive T cell selection (GO:0043368)2.43795379
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.43156688
164negative regulation of interleukin-12 production (GO:0032695)2.42795198
165aromatic amino acid family metabolic process (GO:0009072)2.42749302
166short-chain fatty acid metabolic process (GO:0046459)2.40596153
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40559506
168detection of biotic stimulus (GO:0009595)2.39805630
169activation of JUN kinase activity (GO:0007257)2.39156150
170regulation of T cell tolerance induction (GO:0002664)2.37626534
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36569849
172positive regulation of protein deacetylation (GO:0090312)2.34552789
173negative regulation of type 2 immune response (GO:0002829)2.34516986
174negative regulation of T cell mediated immunity (GO:0002710)2.32966982
175regulation of mast cell activation involved in immune response (GO:0033006)2.32488685
176lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31624682
177positive regulation of receptor recycling (GO:0001921)2.30012584
178regulation of early endosome to late endosome transport (GO:2000641)2.28987131
179cellular extravasation (GO:0045123)2.28771997
180semaphorin-plexin signaling pathway (GO:0071526)2.28743159
181regulation of defense response to virus by virus (GO:0050690)2.27978321
182positive regulation of B cell differentiation (GO:0045579)2.26366046
183positive regulation of cellular amide metabolic process (GO:0034250)2.26066446
184regulation of antigen processing and presentation (GO:0002577)2.24985773
185regulation of necroptotic process (GO:0060544)2.24715441
186negative regulation of glycoprotein biosynthetic process (GO:0010561)2.23959973
187myeloid cell activation involved in immune response (GO:0002275)2.23718897
188positive regulation of antigen processing and presentation (GO:0002579)2.23363058
189regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.23284233
190epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23083957
191response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22938565
192response to host (GO:0075136)2.22938565
193response to host defenses (GO:0052200)2.22938565
194stress fiber assembly (GO:0043149)2.22239654
195apoptotic process involved in morphogenesis (GO:0060561)2.22104564
196detection of molecule of bacterial origin (GO:0032490)2.21591195
197negative regulation of innate immune response (GO:0045824)2.21559004
198modulation by symbiont of host cellular process (GO:0044068)2.20199840
199response to interleukin-15 (GO:0070672)2.19413112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62629247
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.39976244
3VDR_21846776_ChIP-Seq_THP-1_Human3.04530483
4LXR_22158963_ChIP-Seq_LIVER_Mouse2.92263324
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.85724323
6EZH2_22144423_ChIP-Seq_EOC_Human2.57626062
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51851023
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46936909
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.46582486
10MYC_22102868_ChIP-Seq_BL_Human2.46206430
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45409457
12TCF7_22412390_ChIP-Seq_EML_Mouse2.34814596
13DROSHA_22980978_ChIP-Seq_HELA_Human2.32084353
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29286543
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.25310975
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14299676
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14078412
18VDR_24763502_ChIP-Seq_THP-1_Human2.08381328
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92610618
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88682936
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87417406
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85096488
23MAF_26560356_Chip-Seq_TH1_Human1.83590629
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82227380
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77377384
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67595765
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.67044242
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65394730
29UTX_26944678_Chip-Seq_JUKART_Human1.64103600
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63358585
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61084468
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60870638
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60603481
34P68_20966046_ChIP-Seq_HELA_Human1.59815897
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59644035
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.59087116
37MAF_26560356_Chip-Seq_TH2_Human1.58811457
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58250284
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56475525
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.56446110
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55832793
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.55516438
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55340095
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55340095
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53349380
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50474247
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50100338
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48774189
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.47205429
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46127168
51SPI1_23127762_ChIP-Seq_K562_Human1.45533724
52KDM2B_26808549_Chip-Seq_K562_Human1.45193237
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44592933
54SMC4_20622854_ChIP-Seq_HELA_Human1.42497771
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42073825
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.41111322
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41050028
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.40983486
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40889657
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.39915265
61GATA1_22025678_ChIP-Seq_K562_Human1.37091875
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36612014
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35224530
64* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35089263
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34922265
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.33973477
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33351295
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.32678179
69BCOR_27268052_Chip-Seq_Bcells_Human1.32557171
70BCL6_27268052_Chip-Seq_Bcells_Human1.32172413
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.31854536
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30908091
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30706762
74SCL_19346495_ChIP-Seq_HPC-7_Human1.30352623
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.29873144
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29754104
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29525749
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29325500
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29118886
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28639278
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27942880
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27844185
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27537556
84GBX2_23144817_ChIP-Seq_PC3_Human1.27328833
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26787961
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24822669
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.24600420
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.24184762
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23022127
90LXR_22292898_ChIP-Seq_THP-1_Human1.22611588
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22279712
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22275023
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21495705
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21444994
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21240481
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.19878731
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19421220
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19154522
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19051436
100NCOR1_26117541_ChIP-Seq_K562_Human1.18374698
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.18301151
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17724935
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17573601
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.17509812
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17442896
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16166556
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14955989
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13843369
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13275678
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10869547
111RUNX_20019798_ChIP-Seq_JUKART_Human1.10757262
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10612695
113AR_21572438_ChIP-Seq_LNCaP_Human1.09810571
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09285591
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09168707
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08960799
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08343917
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08312791
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08064765
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05742365
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05590690
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04997825
123AHR_22903824_ChIP-Seq_MCF-7_Human1.04446688
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04155989
125EED_16625203_ChIP-ChIP_MESCs_Mouse1.03781646
126* TP63_22573176_ChIP-Seq_HFKS_Human1.03057188
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02297732
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00798296
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.00458527
130P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00008469
131AR_19668381_ChIP-Seq_PC3_Human0.99583310
132GATA1_19941826_ChIP-Seq_K562_Human0.99133380
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.99047485
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97917696
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97847652
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97330304
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96956660
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.96914732
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96659609
140* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94812454
141KDM2B_26808549_Chip-Seq_DND41_Human0.93063785
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91944080
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.90767404
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.90426956
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90254344
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89319762
147HNF4A_19822575_ChIP-Seq_HepG2_Human0.88392466
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88376876
149RXR_22108803_ChIP-Seq_LS180_Human0.88338562
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.85666369
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.84783697
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84641403
153KDM2B_26808549_Chip-Seq_JURKAT_Human0.84466015
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83801598
155SMAD4_21799915_ChIP-Seq_A2780_Human0.82831939
156CREB1_26743006_Chip-Seq_LNCaP_Human0.82308079
157CLOCK_20551151_ChIP-Seq_293T_Human0.81888398
158TP53_16413492_ChIP-PET_HCT116_Human0.81475640
159RACK7_27058665_Chip-Seq_MCF-7_Human0.80637361
160GATA2_19941826_ChIP-Seq_K562_Human0.79315392
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.78573395
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78492578
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.78457732
164DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78422240
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.78133470
166CTCF_27219007_Chip-Seq_Bcells_Human0.78019537
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77835653
168Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76739968
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.76504881
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75410489
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74846173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.63952934
2MP0002139_abnormal_hepatobiliary_system5.80361059
3MP0005085_abnormal_gallbladder_physiolo4.04143288
4MP0004859_abnormal_synaptic_plasticity3.86798342
5MP0005365_abnormal_bile_salt3.81519340
6MP0003436_decreased_susceptibility_to3.49759415
7MP0008875_abnormal_xenobiotic_pharmacok3.42501620
8MP0003252_abnormal_bile_duct3.06625533
9MP0003303_peritoneal_inflammation3.00153919
10MP0010329_abnormal_lipoprotein_level2.63255935
11MP0003724_increased_susceptibility_to2.52912198
12MP0009780_abnormal_chondrocyte_physiolo2.51321629
13MP0001666_abnormal_nutrient_absorption2.51154020
14MP0002822_catalepsy2.50342140
15MP0000569_abnormal_digit_pigmentation2.48301546
16MP0001835_abnormal_antigen_presentation2.44694446
17MP0009840_abnormal_foam_cell2.39714387
18MP0008260_abnormal_autophagy2.35818670
19MP0003635_abnormal_synaptic_transmissio2.16048574
20MP0002419_abnormal_innate_immunity2.07904735
21MP0010155_abnormal_intestine_physiology2.07135710
22MP0005083_abnormal_biliary_tract2.06817424
23MP0005025_abnormal_response_to2.06701389
24MP0010234_abnormal_vibrissa_follicle2.05317409
25MP0005409_darkened_coat_color1.97575104
26MP0003191_abnormal_cellular_cholesterol1.95383328
27MP0009046_muscle_twitch1.93943718
28MP0005387_immune_system_phenotype1.93430166
29MP0001790_abnormal_immune_system1.93430166
30MP0003329_amyloid_beta_deposits1.89347072
31MP0001849_ear_inflammation1.89074467
32MP0005000_abnormal_immune_tolerance1.87609689
33MP0000685_abnormal_immune_system1.86531933
34MP0003763_abnormal_thymus_physiology1.86520202
35MP0003705_abnormal_hypodermis_morpholog1.82722590
36MP0001800_abnormal_humoral_immune1.82282828
37MP0006082_CNS_inflammation1.82102540
38MP0008961_abnormal_basal_metabolism1.80903616
39MP0005671_abnormal_response_to1.78695899
40MP0004270_analgesia1.73429602
41MP0001533_abnormal_skeleton_physiology1.72558705
42MP0000604_amyloidosis1.68986734
43MP0005332_abnormal_amino_acid1.67486172
44MP0001873_stomach_inflammation1.66530492
45MP0002064_seizures1.66306057
46MP0002723_abnormal_immune_serum1.66275472
47MP0002420_abnormal_adaptive_immunity1.65369702
48MP0001819_abnormal_immune_cell1.65035368
49MP0003880_abnormal_central_pattern1.63432175
50MP0002452_abnormal_antigen_presenting1.61654063
51MP0002118_abnormal_lipid_homeostasis1.60812136
52MP0009745_abnormal_behavioral_response1.59269256
53MP0009278_abnormal_bone_marrow1.58696234
54MP0002063_abnormal_learning/memory/cond1.56779174
55MP0003195_calcinosis1.51521490
56MP0003453_abnormal_keratinocyte_physiol1.51134480
57MP0009333_abnormal_splenocyte_physiolog1.50273181
58MP0005076_abnormal_cell_differentiation1.50017468
59MP0002998_abnormal_bone_remodeling1.49920911
60MP0000858_altered_metastatic_potential1.47295670
61MP0004510_myositis1.46605917
62MP0004858_abnormal_nervous_system1.46306823
63MP0005464_abnormal_platelet_physiology1.45722539
64MP0009785_altered_susceptibility_to1.43964865
65MP0004381_abnormal_hair_follicle1.42767845
66MP0000609_abnormal_liver_physiology1.42555394
67MP0001501_abnormal_sleep_pattern1.41919193
68MP0004019_abnormal_vitamin_homeostasis1.38804446
69MP0000678_abnormal_parathyroid_gland1.33751115
70MP0003566_abnormal_cell_adhesion1.33163945
71MP0003183_abnormal_peptide_metabolism1.30466500
72MP0003300_gastrointestinal_ulcer1.29698507
73MP0003279_aneurysm1.29339989
74MP0003172_abnormal_lysosome_physiology1.28498885
75MP0002572_abnormal_emotion/affect_behav1.28176527
76MP0003690_abnormal_glial_cell1.27936758
77MP0001486_abnormal_startle_reflex1.25292030
78MP0001845_abnormal_inflammatory_respons1.24690070
79MP0001440_abnormal_grooming_behavior1.24490639
80MP0002405_respiratory_system_inflammati1.24337440
81MP0002148_abnormal_hypersensitivity_rea1.23590871
82MP0003868_abnormal_feces_composition1.23275405
83MP0000716_abnormal_immune_system1.23122422
84MP0008004_abnormal_stomach_pH1.21537713
85MP0001958_emphysema1.20761679
86MP0005167_abnormal_blood-brain_barrier1.19326508
87MP0002398_abnormal_bone_marrow1.17499478
88MP0002909_abnormal_adrenal_gland1.16954302
89MP0001348_abnormal_lacrimal_gland1.16354036
90MP0002933_joint_inflammation1.14729917
91MP0008569_lethality_at_weaning1.11458984
92MP0000490_abnormal_crypts_of1.10990903
93MP0001663_abnormal_digestive_system1.09871410
94MP0005584_abnormal_enzyme/coenzyme_acti1.09807586
95MP0008874_decreased_physiological_sensi1.09224527
96MP0005423_abnormal_somatic_nervous1.08660246
97MP0002254_reproductive_system_inflammat1.08234984
98MP0003879_abnormal_hair_cell1.07955951
99MP0005535_abnormal_body_temperature1.07530718
100MP0008872_abnormal_physiological_respon1.06656900
101MP0001851_eye_inflammation1.04525775
102MP0004185_abnormal_adipocyte_glucose1.04348737
103MP0008469_abnormal_protein_level1.03128056
104MP0003633_abnormal_nervous_system1.02559155
105MP0005666_abnormal_adipose_tissue1.02065722
106MP0002272_abnormal_nervous_system1.01744611
107MP0005310_abnormal_salivary_gland1.01151226
108MP0004043_abnormal_pH_regulation1.00253076
109MP0001968_abnormal_touch/_nociception1.00204108
110MP0003075_altered_response_to0.98035864
111MP0002396_abnormal_hematopoietic_system0.96882466
112MP0002429_abnormal_blood_cell0.96615950
113MP0004130_abnormal_muscle_cell0.96119823
114MP0002733_abnormal_thermal_nociception0.94851934
115MP0003828_pulmonary_edema0.94598161
116MP0000465_gastrointestinal_hemorrhage0.94004883
117MP0003045_fibrosis0.91528987
118MP0005448_abnormal_energy_balance0.91496785
119MP0005390_skeleton_phenotype0.91411621
120MP0002067_abnormal_sensory_capabilities0.91223352
121MP0005319_abnormal_enzyme/_coenzyme0.91187539
122MP0002722_abnormal_immune_system0.91020524
123MP0002734_abnormal_mechanical_nocicepti0.90756450
124MP0000703_abnormal_thymus_morphology0.90438035
125MP0005381_digestive/alimentary_phenotyp0.89523881
126MP0005386_behavior/neurological_phenoty0.89480493
127MP0004924_abnormal_behavior0.89480493
128MP0005023_abnormal_wound_healing0.89017084
129MP0003806_abnormal_nucleotide_metabolis0.88804551
130MP0005645_abnormal_hypothalamus_physiol0.88181849
131MP0002132_abnormal_respiratory_system0.87740961
132MP0002796_impaired_skin_barrier0.87211783
133MP0003283_abnormal_digestive_organ0.86571485
134MP0003631_nervous_system_phenotype0.85862245
135MP0004885_abnormal_endolymph0.84483811
136MP0004811_abnormal_neuron_physiology0.84215355
137MP0003632_abnormal_nervous_system0.84149906
138MP0001177_atelectasis0.82714977
139MP0002249_abnormal_larynx_morphology0.81789810
140MP0003448_altered_tumor_morphology0.80293258
141MP0005397_hematopoietic_system_phenotyp0.79263183
142MP0001545_abnormal_hematopoietic_system0.79263183
143MP0000689_abnormal_spleen_morphology0.78964517
144MP0005375_adipose_tissue_phenotype0.77316326
145MP0009643_abnormal_urine_homeostasis0.75123735
146MP0002069_abnormal_eating/drinking_beha0.75116074
147MP0000249_abnormal_blood_vessel0.73871556
148MP0002078_abnormal_glucose_homeostasis0.73744011
149MP0004883_abnormal_blood_vessel0.73548532
150MP0000955_abnormal_spinal_cord0.72820375
151MP0000538_abnormal_urinary_bladder0.72027355
152MP0002166_altered_tumor_susceptibility0.71436745
153MP0002557_abnormal_social/conspecific_i0.71281856
154MP0001765_abnormal_ion_homeostasis0.70409158
155MP0000015_abnormal_ear_pigmentation0.69721838
156MP0001970_abnormal_pain_threshold0.69651312
157MP0003795_abnormal_bone_structure0.69395477
158MP0005166_decreased_susceptibility_to0.69176584
159MP0002066_abnormal_motor_capabilities/c0.65841526
160MP0002735_abnormal_chemical_nociception0.65529641
161MP0009764_decreased_sensitivity_to0.65024797
162MP0004264_abnormal_extraembryonic_tissu0.64500889
163MP0002971_abnormal_brown_adipose0.64343953
164MP0002229_neurodegeneration0.63792963
165MP0004947_skin_inflammation0.62780587
166MP0005058_abnormal_lysosome_morphology0.62294417
167MP0002138_abnormal_hepatobiliary_system0.60403731
168MP0004142_abnormal_muscle_tone0.59738773
169MP0003866_abnormal_defecation0.59719149
170MP0002089_abnormal_postnatal_growth/wei0.59346786
171MP0003091_abnormal_cell_migration0.57126540
172MP0009765_abnormal_xenobiotic_induced0.56688631
173MP0002736_abnormal_nociception_after0.55834493
174MP0005451_abnormal_body_composition0.55585927

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.71564774
2Deep venous thrombosis (HP:0002625)4.20226965
3Xanthomatosis (HP:0000991)4.14142233
4Intrahepatic cholestasis (HP:0001406)4.09635310
5Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66642978
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.62826222
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56332185
8Abnormality of macrophages (HP:0004311)3.46018835
9Hypobetalipoproteinemia (HP:0003563)3.43500212
10Recurrent abscess formation (HP:0002722)3.18598842
11Recurrent bacterial skin infections (HP:0005406)3.18150361
12Obstructive sleep apnea (HP:0002870)3.16627942
13Abnormality of the lower motor neuron (HP:0002366)3.03655107
14Focal seizures (HP:0007359)2.99701108
15Hyperlipoproteinemia (HP:0010980)2.98767036
16Epidermoid cyst (HP:0200040)2.98065927
17Complement deficiency (HP:0004431)2.94152059
18Action tremor (HP:0002345)2.93487060
19Myokymia (HP:0002411)2.81553942
20Cellulitis (HP:0100658)2.78302427
21Broad face (HP:0000283)2.77508560
22Hypolipoproteinemia (HP:0010981)2.75028329
23Status epilepticus (HP:0002133)2.74846910
24Myositis (HP:0100614)2.73949268
25Increased IgE level (HP:0003212)2.73199170
26Cerebral aneurysm (HP:0004944)2.72708285
27Supranuclear gaze palsy (HP:0000605)2.72442513
28Ketosis (HP:0001946)2.71849623
29Gingivitis (HP:0000230)2.71800762
30Focal motor seizures (HP:0011153)2.71073247
31Hypercholesterolemia (HP:0003124)2.65266815
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.63326765
33Postural instability (HP:0002172)2.63091104
34Hyperammonemia (HP:0001987)2.62529454
35Visual hallucinations (HP:0002367)2.62322974
36Dysostosis multiplex (HP:0000943)2.59943518
37Hypoalphalipoproteinemia (HP:0003233)2.58012884
38Colitis (HP:0002583)2.57970092
39Hemorrhage of the eye (HP:0011885)2.57137057
40Abnormality of the common coagulation pathway (HP:0010990)2.56785423
41Elevated erythrocyte sedimentation rate (HP:0003565)2.55535533
42Turricephaly (HP:0000262)2.52938238
43Prolonged partial thromboplastin time (HP:0003645)2.49851773
44Hemiplegia (HP:0002301)2.47312065
45Recurrent gram-negative bacterial infections (HP:0005420)2.45823420
46Conjugated hyperbilirubinemia (HP:0002908)2.44143238
47Pustule (HP:0200039)2.43769086
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42321728
49Thin bony cortex (HP:0002753)2.40390006
50Gastrointestinal inflammation (HP:0004386)2.38782519
51Orchitis (HP:0100796)2.37951904
52Abnormal social behavior (HP:0012433)2.36884994
53Impaired social interactions (HP:0000735)2.36884994
54Gastrointestinal infarctions (HP:0005244)2.36432693
55Hyperglycinuria (HP:0003108)2.36374288
56Obstructive lung disease (HP:0006536)2.34750124
57Chronic obstructive pulmonary disease (HP:0006510)2.34750124
58Increased cerebral lipofuscin (HP:0011813)2.32451140
59Tetraplegia (HP:0002445)2.31297912
60Abnormality of serine family amino acid metabolism (HP:0010894)2.30203422
61Abnormality of glycine metabolism (HP:0010895)2.30203422
62Abnormality of proline metabolism (HP:0010907)2.29719450
63Hydroxyprolinuria (HP:0003080)2.29719450
64Recurrent fungal infections (HP:0002841)2.29517563
65Dysmetric saccades (HP:0000641)2.28663880
66Gout (HP:0001997)2.28201460
67Skin nodule (HP:0200036)2.26848688
68Cerebral inclusion bodies (HP:0100314)2.26606704
69Fat malabsorption (HP:0002630)2.26253933
70Inflammation of the large intestine (HP:0002037)2.25539622
71Abnormality of the nasal mucosa (HP:0000433)2.24733248
72Ketoacidosis (HP:0001993)2.23886965
73Sensorimotor neuropathy (HP:0007141)2.23348612
74Intention tremor (HP:0002080)2.22348510
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22215158
76Cervical subluxation (HP:0003308)2.21295247
77Emphysema (HP:0002097)2.21158475
78Spontaneous hematomas (HP:0007420)2.19188035
79Meningitis (HP:0001287)2.18742649
80Flat acetabular roof (HP:0003180)2.17123998
81Acanthocytosis (HP:0001927)2.16706842
82Generalized tonic-clonic seizures (HP:0002069)2.15007166
83Mediastinal lymphadenopathy (HP:0100721)2.14730571
84Mitral stenosis (HP:0001718)2.14444224
85Nasal polyposis (HP:0100582)2.13108002
86Mucopolysacchariduria (HP:0008155)2.12118537
87Urinary glycosaminoglycan excretion (HP:0003541)2.12118537
88Recurrent skin infections (HP:0001581)2.10356226
89Hyperglycinemia (HP:0002154)2.10101758
90Systemic lupus erythematosus (HP:0002725)2.09483003
91Distal lower limb amyotrophy (HP:0008944)2.09339432
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09237976
93Abnormality of polysaccharide metabolism (HP:0011012)2.09237976
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09237976
95Abnormality of purine metabolism (HP:0004352)2.08224162
96Stridor (HP:0010307)2.07731584
97Impaired vibration sensation in the lower limbs (HP:0002166)2.07450187
98Urinary bladder sphincter dysfunction (HP:0002839)2.07426941
99Joint hemorrhage (HP:0005261)2.06884699
100Myocardial infarction (HP:0001658)2.06593004
101J-shaped sella turcica (HP:0002680)2.06007659
102Neurofibrillary tangles (HP:0002185)2.05812846
103Abnormality of glycolipid metabolism (HP:0010969)2.05802761
104Abnormality of liposaccharide metabolism (HP:0010968)2.05802761
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.05802761
106Dysdiadochokinesis (HP:0002075)2.05771659
107Abnormality of the fingertips (HP:0001211)2.05380398
108Loss of speech (HP:0002371)2.04279641
109Neonatal onset (HP:0003623)2.02932010
110Abnormality of the Achilles tendon (HP:0005109)2.02835121
111Prolonged bleeding time (HP:0003010)2.02626273
112Absence seizures (HP:0002121)2.02243491
113Disproportionate tall stature (HP:0001519)2.00051731
114Bone pain (HP:0002653)1.99333431
115Abnormality of complement system (HP:0005339)1.98617359
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.97704136
117Papilledema (HP:0001085)1.97183480
118Polygenic inheritance (HP:0010982)1.95674467
119Segmental peripheral demyelination/remyelination (HP:0003481)1.95429196
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95219949
121Premature loss of primary teeth (HP:0006323)1.95191901
122Macroorchidism (HP:0000053)1.95152240
123Increased neuronal autofluorescent lipopigment (HP:0002074)1.94677414
124Malnutrition (HP:0004395)1.94657676
125Annular pancreas (HP:0001734)1.94152486
126Progressive cerebellar ataxia (HP:0002073)1.92755819
127Hypertriglyceridemia (HP:0002155)1.92708340
128Hyperacusis (HP:0010780)1.92289753
129Reticulocytosis (HP:0001923)1.92143046
130Torticollis (HP:0000473)1.91408216
131Scanning speech (HP:0002168)1.91403805
132Easy fatigability (HP:0003388)1.91393859
133Neuronal loss in central nervous system (HP:0002529)1.91221862
134Slow saccadic eye movements (HP:0000514)1.91103236
135Axonal loss (HP:0003447)1.90925546
136Confusion (HP:0001289)1.90646344
137Protrusio acetabuli (HP:0003179)1.90393512
138Dysmetria (HP:0001310)1.89607119
139Aneurysm (HP:0002617)1.89145141
140Abnormality of the intrinsic pathway (HP:0010989)1.88364854
141Amyloidosis (HP:0011034)1.87273054
142Increased connective tissue (HP:0009025)1.87238193
143Optic neuritis (HP:0100653)1.86273663
144Retrobulbar optic neuritis (HP:0100654)1.86273663
145Peritonitis (HP:0002586)1.84990438
146Ankle clonus (HP:0011448)1.84511796
147Spastic gait (HP:0002064)1.84271239
148Bradykinesia (HP:0002067)1.84017919
149Insomnia (HP:0100785)1.83859132
150Interstitial pulmonary disease (HP:0006530)1.83363660
151Global brain atrophy (HP:0002283)1.82838360
152Recurrent viral infections (HP:0004429)1.82532869
153Spastic tetraparesis (HP:0001285)1.82184947
154Hyperbilirubinemia (HP:0002904)1.82071218
155Vasculitis (HP:0002633)1.81339834
156Urinary urgency (HP:0000012)1.81284926
157Onion bulb formation (HP:0003383)1.79302368
158Chronic mucocutaneous candidiasis (HP:0002728)1.77629009
159Recurrent cutaneous fungal infections (HP:0011370)1.77629009
160Long toe (HP:0010511)1.77603663
161Elfin facies (HP:0004428)1.76746733
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76668001
163Mitral regurgitation (HP:0001653)1.75890919
164Abnormality of nucleobase metabolism (HP:0010932)1.75868342
165Gastrointestinal stroma tumor (HP:0100723)1.75840027
166Chronic otitis media (HP:0000389)1.75570737
167Cholelithiasis (HP:0001081)1.75326285
168Atonic seizures (HP:0010819)1.74771182
169Depression (HP:0000716)1.74587568
170Poor eye contact (HP:0000817)1.74151800
171Dilatation of the ascending aorta (HP:0005111)1.73263754
172Resting tremor (HP:0002322)1.73206917
173Abnormal eating behavior (HP:0100738)1.73154482
174Hypophosphatemia (HP:0002148)1.73103577
175Widely patent fontanelles and sutures (HP:0004492)1.72462663
176Abnormality of the thoracic spine (HP:0100711)1.72388020
177Spastic diplegia (HP:0001264)1.72342848
178Encephalitis (HP:0002383)1.72066572
179Dialeptic seizures (HP:0011146)1.71677132
180Postural tremor (HP:0002174)1.71528603
181Gastrointestinal dysmotility (HP:0002579)1.71412621
182Upper limb amyotrophy (HP:0009129)1.71300233
183Distal upper limb amyotrophy (HP:0007149)1.71300233
184Fragile skin (HP:0001030)1.70297065
185Osteomyelitis (HP:0002754)1.69086982
186Purpura (HP:0000979)1.68885800
187Metaphyseal cupping (HP:0003021)1.68751606
188Atrophic scars (HP:0001075)1.67513166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.47029458
2MAP3K93.40962396
3NTRK32.84061287
4MAP4K12.74609788
5EPHA42.59645600
6DAPK22.27543056
7SMG12.11483285
8RIPK11.92761249
9MAP2K41.91078527
10KSR21.90645873
11MAP2K31.88933802
12MAP3K41.87199750
13MAP3K131.85722925
14SIK11.84887854
15SIK21.82938202
16MST1R1.81625246
17NTRK21.77988570
18FGFR41.72634832
19TNK21.72005473
20PTK61.64064118
21ERN11.63576575
22MAP3K111.61408892
23IRAK31.58342349
24CAMKK11.57603325
25NTRK11.56844906
26MARK11.55955398
27RIPK41.54084223
28BLK1.52150347
29ZAP701.51666988
30PAK61.51571209
31STK381.51104537
32CAMK1G1.49786839
33EPHA21.48304317
34EEF2K1.46436114
35MAP3K21.46371936
36IRAK41.45336617
37CSK1.43027757
38CAMK1D1.42684631
39PRKD21.41810621
40TRIB31.40940576
41MAP3K101.35873855
42LMTK21.34848880
43INSRR1.31845072
44SGK31.29773352
45MINK11.28033597
46TYRO31.27186989
47RET1.23183868
48PRKCH1.19797841
49MAP3K71.18660030
50MAP3K31.18174494
51TAOK11.14683122
52GRK61.14468772
53JAK11.13798993
54BTK1.12587271
55WNK11.09632297
56PKN21.07675453
57SCYL21.06564698
58PDPK11.03749885
59PDGFRA1.03705589
60FRK1.02928554
61BMX1.02111110
62CDK51.00514796
63MAP3K141.00474119
64PTK20.99704433
65JAK30.99564480
66TAOK20.98748952
67TAOK30.98142581
68FGFR20.94665378
69SIK30.93353234
70ALK0.92346153
71EPHB10.91818661
72PAK40.91406540
73HCK0.90697369
74PDK10.89860451
75MAP3K60.88138839
76MAPK120.85339846
77SGK2230.84459296
78SGK4940.84459296
79SGK20.84037419
80KSR10.81730847
81IRAK20.81203716
82JAK20.80396125
83CDC42BPA0.79468748
84CSF1R0.76572861
85ICK0.76503907
86BCKDK0.75074295
87STK110.74011658
88CDK120.73985808
89FGR0.72833006
90FER0.72628518
91ERBB20.72329842
92FES0.71312905
93MAP3K10.69887059
94HIPK20.69576922
95TGFBR20.69231802
96IKBKE0.69119890
97TBK10.68930392
98SYK0.68895213
99PRKD30.68778698
100RPS6KL10.67851239
101RPS6KC10.67851239
102ITK0.66433167
103SGK10.66190547
104ERBB40.65088190
105CAMKK20.64809094
106DYRK1B0.64303009
107PHKG10.63233661
108PHKG20.63233661
109LRRK20.62305042
110PRKCG0.61993325
111LCK0.61862746
112PRKCZ0.61536693
113PAK30.61235484
114PRKAA10.59362612
115MARK20.58785241
116MAP2K60.57545599
117DDR20.57105727
118TESK20.56041202
119TYK20.55280541
120ARAF0.54889357
121FGFR30.54756550
122RPS6KA30.54702985
123MAPK110.54549350
124CAMK40.54195761
125MET0.53652509
126TESK10.53078202
127MAPK70.52686275
128MAP2K10.52649912
129PRKAA20.52013447
130MTOR0.51579737
131GRK50.51563480
132FYN0.51333222
133TTN0.51227249
134MAP2K20.51143932
135DAPK10.50121276
136RPS6KA20.49503215
137CAMK10.49462439
138RPS6KA60.48517348
139PDGFRB0.48475779
140PRKACG0.48343713
141LYN0.46466470
142PRKG20.45603329
143LATS20.45446897
144PTK2B0.43885674
145CAMK2G0.42011725
146MAPK150.38842017
147MOS0.38148161
148NME20.37743306
149MAP3K80.34647385

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.74208271
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.78693368
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75404034
4Other glycan degradation_Homo sapiens_hsa005112.55018470
5Arginine biosynthesis_Homo sapiens_hsa002202.53441971
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28393230
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18441457
8Bile secretion_Homo sapiens_hsa049762.18250924
9Osteoclast differentiation_Homo sapiens_hsa043802.01067180
10B cell receptor signaling pathway_Homo sapiens_hsa046621.94984470
11Acute myeloid leukemia_Homo sapiens_hsa052211.83518166
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82191709
13Tryptophan metabolism_Homo sapiens_hsa003801.81647754
14Leishmaniasis_Homo sapiens_hsa051401.74512492
15Butanoate metabolism_Homo sapiens_hsa006501.64790108
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60708923
17VEGF signaling pathway_Homo sapiens_hsa043701.60320520
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57973822
19Notch signaling pathway_Homo sapiens_hsa043301.55209978
20Fatty acid degradation_Homo sapiens_hsa000711.51656724
21Fat digestion and absorption_Homo sapiens_hsa049751.45024425
22Complement and coagulation cascades_Homo sapiens_hsa046101.44983583
23PPAR signaling pathway_Homo sapiens_hsa033201.44593108
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44130193
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42861712
26Chronic myeloid leukemia_Homo sapiens_hsa052201.36225066
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32379389
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.30814211
29T cell receptor signaling pathway_Homo sapiens_hsa046601.30495621
30Caffeine metabolism_Homo sapiens_hsa002321.30404589
31ABC transporters_Homo sapiens_hsa020101.29107702
32Tuberculosis_Homo sapiens_hsa051521.28984266
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27983664
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27150282
35Non-small cell lung cancer_Homo sapiens_hsa052231.26596262
36Nicotine addiction_Homo sapiens_hsa050331.26212521
37Synaptic vesicle cycle_Homo sapiens_hsa047211.24732371
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.24300426
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23496743
40Toxoplasmosis_Homo sapiens_hsa051451.22394108
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21311880
42Starch and sucrose metabolism_Homo sapiens_hsa005001.18520388
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.18440850
44Type II diabetes mellitus_Homo sapiens_hsa049301.16867705
45Chemokine signaling pathway_Homo sapiens_hsa040621.16746544
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16438043
47Fatty acid metabolism_Homo sapiens_hsa012121.14754069
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.13975419
49Lysine degradation_Homo sapiens_hsa003101.13741406
50TNF signaling pathway_Homo sapiens_hsa046681.13246723
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13045631
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11855775
53GABAergic synapse_Homo sapiens_hsa047271.09467689
54Hepatitis C_Homo sapiens_hsa051601.08751682
55Histidine metabolism_Homo sapiens_hsa003401.06619285
56Endometrial cancer_Homo sapiens_hsa052131.05293087
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04384366
58Renal cell carcinoma_Homo sapiens_hsa052111.02917758
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02913109
60Graft-versus-host disease_Homo sapiens_hsa053321.02554862
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02397518
62Allograft rejection_Homo sapiens_hsa053301.01515903
63Pancreatic cancer_Homo sapiens_hsa052121.00820993
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.99175696
65Influenza A_Homo sapiens_hsa051640.98910688
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98717748
67Salivary secretion_Homo sapiens_hsa049700.98559408
68Glutamatergic synapse_Homo sapiens_hsa047240.96486257
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96435443
70Primary immunodeficiency_Homo sapiens_hsa053400.95423024
71Endocytosis_Homo sapiens_hsa041440.93413707
72Inositol phosphate metabolism_Homo sapiens_hsa005620.93390601
73Fructose and mannose metabolism_Homo sapiens_hsa000510.93274654
74Prolactin signaling pathway_Homo sapiens_hsa049170.93234543
75Phenylalanine metabolism_Homo sapiens_hsa003600.93213430
76Platelet activation_Homo sapiens_hsa046110.92340307
77Lysosome_Homo sapiens_hsa041420.92281766
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92223164
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91529741
80Autoimmune thyroid disease_Homo sapiens_hsa053200.91506586
81Insulin secretion_Homo sapiens_hsa049110.91366169
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91346861
83beta-Alanine metabolism_Homo sapiens_hsa004100.91246944
84Long-term potentiation_Homo sapiens_hsa047200.89686050
85Peroxisome_Homo sapiens_hsa041460.89259753
86Hepatitis B_Homo sapiens_hsa051610.88949688
87Gastric acid secretion_Homo sapiens_hsa049710.88341547
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88338690
89Circadian entrainment_Homo sapiens_hsa047130.88204183
90mTOR signaling pathway_Homo sapiens_hsa041500.87914963
91Amoebiasis_Homo sapiens_hsa051460.87897114
92* Choline metabolism in cancer_Homo sapiens_hsa052310.87599245
93Mineral absorption_Homo sapiens_hsa049780.85967844
94Amphetamine addiction_Homo sapiens_hsa050310.85765423
95Salmonella infection_Homo sapiens_hsa051320.85517708
96Pertussis_Homo sapiens_hsa051330.85000501
97Propanoate metabolism_Homo sapiens_hsa006400.84776498
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84227947
99Malaria_Homo sapiens_hsa051440.83923489
100Cocaine addiction_Homo sapiens_hsa050300.82813859
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82700464
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.82628228
103Staphylococcus aureus infection_Homo sapiens_hsa051500.81907029
104Viral myocarditis_Homo sapiens_hsa054160.81759311
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81639802
106Prion diseases_Homo sapiens_hsa050200.80592833
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80340089
108Measles_Homo sapiens_hsa051620.80165729
109Insulin signaling pathway_Homo sapiens_hsa049100.77317095
110* Glycerolipid metabolism_Homo sapiens_hsa005610.75639031
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75577210
112Apoptosis_Homo sapiens_hsa042100.75416327
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75213399
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73885821
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73028000
116Morphine addiction_Homo sapiens_hsa050320.71500657
117Sulfur metabolism_Homo sapiens_hsa009200.70947589
118Vitamin digestion and absorption_Homo sapiens_hsa049770.70546681
119Dopaminergic synapse_Homo sapiens_hsa047280.69843810
120Shigellosis_Homo sapiens_hsa051310.69643490
121Hematopoietic cell lineage_Homo sapiens_hsa046400.69641333
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.69184061
123Phagosome_Homo sapiens_hsa041450.68866470
124Olfactory transduction_Homo sapiens_hsa047400.68528263
125Bladder cancer_Homo sapiens_hsa052190.68392054
126Antigen processing and presentation_Homo sapiens_hsa046120.67979151
127Chemical carcinogenesis_Homo sapiens_hsa052040.67292225
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66982342
129GnRH signaling pathway_Homo sapiens_hsa049120.66753899
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66317601
131Rap1 signaling pathway_Homo sapiens_hsa040150.66297142
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.66174826
133Focal adhesion_Homo sapiens_hsa045100.66155465
134Fatty acid biosynthesis_Homo sapiens_hsa000610.65737503
135Cholinergic synapse_Homo sapiens_hsa047250.65065053
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.64452146
137Herpes simplex infection_Homo sapiens_hsa051680.64391283
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64273342
139Colorectal cancer_Homo sapiens_hsa052100.64218706
140Insulin resistance_Homo sapiens_hsa049310.63594276
141Thyroid hormone synthesis_Homo sapiens_hsa049180.62090711
142Dorso-ventral axis formation_Homo sapiens_hsa043200.61923374
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60954634
144* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60367708
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60019037
146Tyrosine metabolism_Homo sapiens_hsa003500.59980002
147Selenocompound metabolism_Homo sapiens_hsa004500.59579531
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.59455749
149Steroid biosynthesis_Homo sapiens_hsa001000.58843971
150Renin secretion_Homo sapiens_hsa049240.58494868
151Pyruvate metabolism_Homo sapiens_hsa006200.58356947
152Long-term depression_Homo sapiens_hsa047300.58259581
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57851757
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57177921
155African trypanosomiasis_Homo sapiens_hsa051430.57132499
156Type I diabetes mellitus_Homo sapiens_hsa049400.56234046
157MAPK signaling pathway_Homo sapiens_hsa040100.56189831
158Retinol metabolism_Homo sapiens_hsa008300.55796304
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54868043
160Thyroid cancer_Homo sapiens_hsa052160.53846861
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.53461712
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52498214
163Renin-angiotensin system_Homo sapiens_hsa046140.51960855
164Drug metabolism - other enzymes_Homo sapiens_hsa009830.51724357
165Intestinal immune network for IgA production_Homo sapiens_hsa046720.51559715
166Galactose metabolism_Homo sapiens_hsa000520.50018137
167Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49965589
168Estrogen signaling pathway_Homo sapiens_hsa049150.49702507
169Taste transduction_Homo sapiens_hsa047420.47303879
170Glucagon signaling pathway_Homo sapiens_hsa049220.46152765
171Pancreatic secretion_Homo sapiens_hsa049720.45928488
172* Glycerophospholipid metabolism_Homo sapiens_hsa005640.45907301
173* Phospholipase D signaling pathway_Homo sapiens_hsa040720.43931722
174Carbon metabolism_Homo sapiens_hsa012000.43455052
175Biosynthesis of amino acids_Homo sapiens_hsa012300.42933119
176Oxytocin signaling pathway_Homo sapiens_hsa049210.42870806
177Calcium signaling pathway_Homo sapiens_hsa040200.41997314
178Glioma_Homo sapiens_hsa052140.40440173
179ErbB signaling pathway_Homo sapiens_hsa040120.39961345
180cAMP signaling pathway_Homo sapiens_hsa040240.39107237

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