DGKZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.09589001
2locomotory exploration behavior (GO:0035641)5.95555566
3sodium ion export (GO:0071436)5.58269514
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51889879
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96150863
6negative regulation of erythrocyte differentiation (GO:0045647)4.94404639
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94216801
8glutamate secretion (GO:0014047)4.83785482
9cellular potassium ion homeostasis (GO:0030007)4.78577786
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.78419609
11synaptic vesicle exocytosis (GO:0016079)4.53955106
12neuronal action potential propagation (GO:0019227)4.51485040
13regulation of ARF protein signal transduction (GO:0032012)4.48896709
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33555929
15regulation of synaptic vesicle exocytosis (GO:2000300)4.32758423
16vocalization behavior (GO:0071625)4.31602347
17cerebellar Purkinje cell differentiation (GO:0021702)4.26607997
18negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.15813950
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14493751
20negative regulation of cell killing (GO:0031342)4.14493751
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.12053344
22regulation of glutamate receptor signaling pathway (GO:1900449)4.06541593
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01672887
24neurotransmitter secretion (GO:0007269)3.96292738
25regulation of synaptic vesicle transport (GO:1902803)3.90143029
26exploration behavior (GO:0035640)3.89729090
27antigen processing and presentation of endogenous antigen (GO:0019883)3.89501434
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88203495
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83754001
30layer formation in cerebral cortex (GO:0021819)3.82664133
31positive thymic T cell selection (GO:0045059)3.80304190
32activation of protein kinase A activity (GO:0034199)3.76873732
33regulation of neuronal synaptic plasticity (GO:0048168)3.71875626
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68073302
35long-term memory (GO:0007616)3.67560044
36proline transport (GO:0015824)3.64177498
37leukocyte aggregation (GO:0070486)3.63867048
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61280158
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60989502
40regulation of ARF GTPase activity (GO:0032312)3.60903958
41synaptic transmission, glutamatergic (GO:0035249)3.60279009
42regulation of synapse structural plasticity (GO:0051823)3.59096083
43potassium ion import (GO:0010107)3.58998868
44gamma-aminobutyric acid transport (GO:0015812)3.58936160
45thymic T cell selection (GO:0045061)3.53309231
46neuromuscular process controlling balance (GO:0050885)3.51109971
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50385849
48glutamate receptor signaling pathway (GO:0007215)3.49463585
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47087081
50positive regulation of synapse maturation (GO:0090129)3.42664068
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.42304345
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39437522
53membrane depolarization during action potential (GO:0086010)3.36784266
54cell communication by electrical coupling (GO:0010644)3.36646817
55regulation of gamma-delta T cell activation (GO:0046643)3.34102476
56cellular sodium ion homeostasis (GO:0006883)3.33478258
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.33127321
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29689948
59mannose metabolic process (GO:0006013)3.27995547
60protein localization to synapse (GO:0035418)3.25403204
61regulation of B cell receptor signaling pathway (GO:0050855)3.21038116
62synaptic vesicle endocytosis (GO:0048488)3.20232343
63signal complex assembly (GO:0007172)3.19665441
64regulation of regulated secretory pathway (GO:1903305)3.17947652
65T cell selection (GO:0045058)3.16804305
66detection of bacterium (GO:0016045)3.14172030
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13826042
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.13826042
69modulation by symbiont of host immune response (GO:0052553)3.13826042
70positive regulation by symbiont of host defense response (GO:0052509)3.13826042
71modulation by symbiont of host defense response (GO:0052031)3.13826042
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13826042
73positive regulation of membrane potential (GO:0045838)3.13519983
74detection of other organism (GO:0098543)3.10049945
75cerebellar granule cell differentiation (GO:0021707)3.07987592
76positive T cell selection (GO:0043368)3.07934000
77regulation of leukocyte degranulation (GO:0043300)3.07492691
78regulation of synaptic plasticity (GO:0048167)3.06189919
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03002034
80response to muramyl dipeptide (GO:0032495)3.02380677
81neuron-neuron synaptic transmission (GO:0007270)3.01042670
82regulation of postsynaptic membrane potential (GO:0060078)3.00666224
83regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00580458
84L-amino acid import (GO:0043092)2.98409641
85neuromuscular process controlling posture (GO:0050884)2.97839673
86dendritic spine morphogenesis (GO:0060997)2.97541445
87glycine transport (GO:0015816)2.95735606
88regulation of clathrin-mediated endocytosis (GO:2000369)2.95174346
89negative regulation of leukocyte mediated immunity (GO:0002704)2.93741243
90macrophage activation involved in immune response (GO:0002281)2.93443405
91positive regulation of fibroblast migration (GO:0010763)2.90723425
92neurotransmitter-gated ion channel clustering (GO:0072578)2.90671729
93regulation of neurotransmitter secretion (GO:0046928)2.89874149
94membrane depolarization (GO:0051899)2.89648099
95positive regulation of Rap GTPase activity (GO:0032854)2.89613474
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89530082
97neurotransmitter transport (GO:0006836)2.89516356
98B cell receptor signaling pathway (GO:0050853)2.87982420
99establishment of nucleus localization (GO:0040023)2.86677836
100regulation of Rap GTPase activity (GO:0032317)2.86071282
101positive regulation of protein dephosphorylation (GO:0035307)2.85824830
102cell differentiation in hindbrain (GO:0021533)2.85678323
103response to peptidoglycan (GO:0032494)2.83160923
104negative regulation of lymphocyte mediated immunity (GO:0002707)2.81976185
105neutrophil activation involved in immune response (GO:0002283)2.80926607
106vesicle transport along microtubule (GO:0047496)2.80573145
107regulation of neurotransmitter levels (GO:0001505)2.79583297
108regulation of dendritic spine morphogenesis (GO:0061001)2.78221997
109regulation of T-helper 2 cell differentiation (GO:0045628)2.77857271
110amino acid import (GO:0043090)2.76909106
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.76327188
112membrane repolarization (GO:0086009)2.74495380
113clathrin coat assembly (GO:0048268)2.73814509
114regulation of mast cell degranulation (GO:0043304)2.73191074
115peptidyl-tyrosine autophosphorylation (GO:0038083)2.72811106
116nerve growth factor signaling pathway (GO:0038180)2.71252323
117potassium ion homeostasis (GO:0055075)2.70178622
118actin filament capping (GO:0051693)2.69430381
119chemosensory behavior (GO:0007635)2.69256393
120long-term synaptic potentiation (GO:0060291)2.68963112
121regulation of voltage-gated calcium channel activity (GO:1901385)2.67990725
122cellular extravasation (GO:0045123)2.67603809
123response to interleukin-15 (GO:0070672)2.67468568
124positive regulation of gamma-delta T cell activation (GO:0046645)2.65199559
125germinal center formation (GO:0002467)2.63964147
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63638157
127alanine transport (GO:0032328)2.62383267
128negative regulation of T cell mediated immunity (GO:0002710)2.61861788
129prepulse inhibition (GO:0060134)2.61415191
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61039011
131regulation of defense response to virus by virus (GO:0050690)2.57603214
132regulation of neurotransmitter transport (GO:0051588)2.56206928
133regulation of gamma-delta T cell differentiation (GO:0045586)2.54542191
134regulation of beta-amyloid formation (GO:1902003)2.54369292
135dendrite morphogenesis (GO:0048813)2.53851641
136mast cell degranulation (GO:0043303)2.53653847
137mast cell activation involved in immune response (GO:0002279)2.53653847
138negative thymic T cell selection (GO:0045060)2.53100897
139negative T cell selection (GO:0043383)2.52308456
140regulation of amyloid precursor protein catabolic process (GO:1902991)2.52131225
141neuromuscular process (GO:0050905)2.52042395
142positive regulation of B cell differentiation (GO:0045579)2.50807791
143actin filament polymerization (GO:0030041)2.49818388
144positive regulation of potassium ion transmembrane transport (GO:1901381)2.49535914
145cell communication involved in cardiac conduction (GO:0086065)2.49099092
146regulation of synapse maturation (GO:0090128)2.44963511
147protein localization to endosome (GO:0036010)2.42949331
148positive regulation of regulated secretory pathway (GO:1903307)2.42316654
149negative regulation of type 2 immune response (GO:0002829)2.42213509
150negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40184184
151Peyers patch development (GO:0048541)2.39049337
152mucosal-associated lymphoid tissue development (GO:0048537)2.39049337
153myeloid cell activation involved in immune response (GO:0002275)2.38551591
154activation of JUN kinase activity (GO:0007257)2.38493806
155regulation of mast cell activation involved in immune response (GO:0033006)2.35944847
156adenosine receptor signaling pathway (GO:0001973)2.31718636
157regulation of B cell differentiation (GO:0045577)2.31083999
158activation of Rac GTPase activity (GO:0032863)2.28930229
159antigen processing and presentation via MHC class Ib (GO:0002475)2.28923979
160modulation by virus of host process (GO:0019054)2.27082470
161detection of external biotic stimulus (GO:0098581)2.26474140
162T cell migration (GO:0072678)2.25131170
163negative regulation of phagocytosis (GO:0050765)2.24994286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.82070372
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.22275688
3DROSHA_22980978_ChIP-Seq_HELA_Human3.08182635
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.96816537
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.94714431
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78685956
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.71137234
8* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61029236
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51399940
10* KDM2B_26808549_Chip-Seq_DND41_Human2.41719315
11MYC_22102868_ChIP-Seq_BL_Human2.28980050
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.19535921
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15978201
14* KDM2B_26808549_Chip-Seq_K562_Human2.13030232
15* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.08314009
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.01188044
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99980577
18* LXR_22292898_ChIP-Seq_THP-1_Human1.97489024
19* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.96144320
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96109889
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94791043
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.94744014
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93738660
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.92773106
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90746428
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.89798459
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88466630
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86195452
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86195452
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85531536
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82030929
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.81842216
33* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78911449
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77961905
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76797952
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.76385228
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75517240
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74296496
39* SPI1_23127762_ChIP-Seq_K562_Human1.68741959
40* VDR_21846776_ChIP-Seq_THP-1_Human1.64764689
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64037945
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62946353
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62829742
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59810094
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59804819
46RUNX_20019798_ChIP-Seq_JUKART_Human1.59186245
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53080057
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51447605
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.49677917
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48215001
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.47031979
52GATA1_19941826_ChIP-Seq_K562_Human1.46998172
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46845089
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46421162
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43392211
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42304972
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41598274
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41043703
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40612915
60* RNF2_27304074_Chip-Seq_ESCs_Mouse1.38973979
61SCL_19346495_ChIP-Seq_HPC-7_Human1.38330459
62MAF_26560356_Chip-Seq_TH1_Human1.38049749
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36962041
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35664855
65BCOR_27268052_Chip-Seq_Bcells_Human1.33697718
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32527754
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32041462
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.31731015
69UTX_26944678_Chip-Seq_JUKART_Human1.30725940
70* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28586275
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28321829
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27598540
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27351881
74* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26800472
75* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.26252195
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25418067
77* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23000286
78* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21615167
79* BCL6_27268052_Chip-Seq_Bcells_Human1.20645917
80SMC4_20622854_ChIP-Seq_HELA_Human1.20483343
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19702163
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19059122
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18422064
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18358894
85* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18337548
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.17256717
87* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16961291
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14025719
89CREB1_26743006_Chip-Seq_LNCaP_Human1.13860290
90GATA1_22025678_ChIP-Seq_K562_Human1.13847144
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11897108
92P68_20966046_ChIP-Seq_HELA_Human1.11372467
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11220706
94ZNF263_19887448_ChIP-Seq_K562_Human1.10824679
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09461066
96* VDR_24763502_ChIP-Seq_THP-1_Human1.08980652
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.07195480
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.06445404
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06341024
100* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06010285
101SA1_27219007_Chip-Seq_Bcells_Human1.05339944
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05293701
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04466200
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.04108027
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03807931
106* RACK7_27058665_Chip-Seq_MCF-7_Human1.03366058
107AR_19668381_ChIP-Seq_PC3_Human1.03261674
108MYB_26560356_Chip-Seq_TH1_Human1.02781101
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02289669
110MYB_26560356_Chip-Seq_TH2_Human1.02184948
111NCOR1_26117541_ChIP-Seq_K562_Human1.02112907
112* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02055325
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00812637
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99621700
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99135442
116* SPI1_23547873_ChIP-Seq_NB4_Human0.98945607
117CTCF_27219007_Chip-Seq_Bcells_Human0.98471023
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98249504
119* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98214214
120* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97731765
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.97324781
122ETS1_21867929_ChIP-Seq_TH2_Mouse0.97069459
123GATA2_19941826_ChIP-Seq_K562_Human0.96710888
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96454917
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96450271
126* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96080288
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94515946
128AR_21572438_ChIP-Seq_LNCaP_Human0.92613792
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92457198
130MAF_26560356_Chip-Seq_TH2_Human0.90871883
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.89823155
132* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89395078
133* SA1_27219007_Chip-Seq_ERYTHROID_Human0.88808547
134* OCT4_19829295_ChIP-Seq_ESCs_Human0.88717065
135* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87357388
136KLF4_19829295_ChIP-Seq_ESCs_Human0.86928946
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.86716028
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.86615473
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85296138
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84950444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.30101223
2MP0003635_abnormal_synaptic_transmissio3.85531605
3MP0003436_decreased_susceptibility_to3.25812097
4MP0001968_abnormal_touch/_nociception3.14567889
5MP0004270_analgesia3.08221532
6MP0009046_muscle_twitch3.06712840
7MP0008569_lethality_at_weaning2.87424357
8MP0009745_abnormal_behavioral_response2.86258364
9MP0002064_seizures2.82638823
10MP0002063_abnormal_learning/memory/cond2.80335056
11MP0002736_abnormal_nociception_after2.60876081
12MP0002735_abnormal_chemical_nociception2.59471357
13MP0003880_abnormal_central_pattern2.47394581
14MP0004510_myositis2.40161212
15MP0004858_abnormal_nervous_system2.29995954
16MP0002272_abnormal_nervous_system2.23350397
17MP0002572_abnormal_emotion/affect_behav2.21263531
18MP0008260_abnormal_autophagy2.15871525
19MP0002734_abnormal_mechanical_nocicepti2.15562456
20MP0000569_abnormal_digit_pigmentation2.12285509
21MP0003724_increased_susceptibility_to2.07828971
22MP0001835_abnormal_antigen_presentation2.02214310
23MP0005423_abnormal_somatic_nervous2.01891014
24MP0003329_amyloid_beta_deposits2.01608494
25MP0002419_abnormal_innate_immunity1.97402696
26MP0008961_abnormal_basal_metabolism1.90462832
27MP0002733_abnormal_thermal_nociception1.90321024
28MP0003191_abnormal_cellular_cholesterol1.90223386
29* MP0005000_abnormal_immune_tolerance1.89016716
30* MP0005025_abnormal_response_to1.87409153
31MP0002822_catalepsy1.86824536
32MP0001970_abnormal_pain_threshold1.83370089
33MP0001501_abnormal_sleep_pattern1.83154602
34MP0003172_abnormal_lysosome_physiology1.82389604
35MP0003705_abnormal_hypodermis_morpholog1.80970103
36MP0002067_abnormal_sensory_capabilities1.77454742
37MP0004811_abnormal_neuron_physiology1.77351626
38MP0005451_abnormal_body_composition1.74084154
39MP0001440_abnormal_grooming_behavior1.73564249
40MP0001486_abnormal_startle_reflex1.69700130
41MP0005387_immune_system_phenotype1.64285629
42MP0001790_abnormal_immune_system1.64285629
43MP0003300_gastrointestinal_ulcer1.62363324
44MP0003303_peritoneal_inflammation1.61761375
45MP0002909_abnormal_adrenal_gland1.61355112
46* MP0002723_abnormal_immune_serum1.60624458
47MP0003633_abnormal_nervous_system1.59673159
48MP0003879_abnormal_hair_cell1.56848306
49MP0009780_abnormal_chondrocyte_physiolo1.55189402
50MP0002452_abnormal_antigen_presenting1.49036154
51MP0003075_altered_response_to1.47561365
52MP0004145_abnormal_muscle_electrophysio1.42947750
53MP0010234_abnormal_vibrissa_follicle1.41969970
54MP0001533_abnormal_skeleton_physiology1.41179732
55MP0006082_CNS_inflammation1.39356054
56MP0000604_amyloidosis1.38294100
57MP0009333_abnormal_splenocyte_physiolog1.33357161
58MP0005167_abnormal_blood-brain_barrier1.33061224
59MP0002184_abnormal_innervation1.32929661
60MP0010155_abnormal_intestine_physiology1.32105351
61MP0008874_decreased_physiological_sensi1.29428939
62MP0004885_abnormal_endolymph1.27044186
63MP0005386_behavior/neurological_phenoty1.25971264
64MP0004924_abnormal_behavior1.25971264
65MP0003631_nervous_system_phenotype1.25757820
66MP0001851_eye_inflammation1.24767435
67MP0000955_abnormal_spinal_cord1.23779476
68MP0003787_abnormal_imprinting1.21363439
69MP0004185_abnormal_adipocyte_glucose1.19600331
70MP0002557_abnormal_social/conspecific_i1.19360412
71MP0004381_abnormal_hair_follicle1.19249369
72MP0002066_abnormal_motor_capabilities/c1.17957058
73MP0005076_abnormal_cell_differentiation1.17147734
74MP0005409_darkened_coat_color1.17044137
75MP0003866_abnormal_defecation1.16273986
76MP0003045_fibrosis1.14665149
77MP0002998_abnormal_bone_remodeling1.10527782
78MP0001849_ear_inflammation1.10408639
79MP0001348_abnormal_lacrimal_gland1.08629986
80MP0002405_respiratory_system_inflammati1.08594560
81MP0002148_abnormal_hypersensitivity_rea1.07823828
82MP0009785_altered_susceptibility_to1.07752143
83MP0008872_abnormal_physiological_respon1.07506602
84MP0003828_pulmonary_edema1.04869201
85* MP0002429_abnormal_blood_cell1.04820965
86MP0004130_abnormal_muscle_cell1.04472786
87MP0003690_abnormal_glial_cell1.02248252
88MP0000751_myopathy0.99935618
89MP0003763_abnormal_thymus_physiology0.97495137
90MP0000689_abnormal_spleen_morphology0.96654559
91MP0000465_gastrointestinal_hemorrhage0.96312630
92MP0000858_altered_metastatic_potential0.95439735
93MP0002882_abnormal_neuron_morphology0.94363745
94MP0009278_abnormal_bone_marrow0.93166236
95MP0001845_abnormal_inflammatory_respons0.92687120
96MP0005464_abnormal_platelet_physiology0.92556806
97MP0005666_abnormal_adipose_tissue0.92055701
98MP0000920_abnormal_myelination0.91111953
99MP0002089_abnormal_postnatal_growth/wei0.90182362
100MP0005166_decreased_susceptibility_to0.89878860
101MP0003632_abnormal_nervous_system0.89841008
102MP0004484_altered_response_of0.89726777
103MP0009840_abnormal_foam_cell0.88206406
104MP0000747_muscle_weakness0.86934046
105MP0001986_abnormal_taste_sensitivity0.84567730
106MP0005310_abnormal_salivary_gland0.82925673
107MP0005671_abnormal_response_to0.80703257
108MP0000703_abnormal_thymus_morphology0.78518082
109* MP0002398_abnormal_bone_marrow0.77794415
110MP0003183_abnormal_peptide_metabolism0.77595590
111MP0002152_abnormal_brain_morphology0.76536753
112MP0003091_abnormal_cell_migration0.76049044
113MP0003656_abnormal_erythrocyte_physiolo0.75135920
114MP0004147_increased_porphyrin_level0.74733121
115MP0004808_abnormal_hematopoietic_stem0.74039473
116MP0005535_abnormal_body_temperature0.73893202
117MP0001502_abnormal_circadian_rhythm0.72045448
118MP0003123_paternal_imprinting0.71665277
119MP0008770_decreased_survivor_rate0.71648011
120MP0002229_neurodegeneration0.70704602
121MP0002069_abnormal_eating/drinking_beha0.70596444
122MP0002933_joint_inflammation0.70314719
123MP0001873_stomach_inflammation0.67643306
124MP0005375_adipose_tissue_phenotype0.66383980
125MP0005058_abnormal_lysosome_morphology0.66078828
126MP0004142_abnormal_muscle_tone0.65812306
127MP0000685_abnormal_immune_system0.65112918
128MP0005174_abnormal_tail_pigmentation0.62817802
129MP0001800_abnormal_humoral_immune0.62506353
130MP0001545_abnormal_hematopoietic_system0.60979602
131MP0005397_hematopoietic_system_phenotyp0.60979602
132* MP0002420_abnormal_adaptive_immunity0.60573994
133MP0003634_abnormal_glial_cell0.59872312
134MP0000778_abnormal_nervous_system0.59314588
135MP0004085_abnormal_heartbeat0.59154812
136* MP0001819_abnormal_immune_cell0.59063636
137MP0002396_abnormal_hematopoietic_system0.57641528
138MP0002083_premature_death0.56652320
139MP0002166_altered_tumor_susceptibility0.55405025
140MP0004947_skin_inflammation0.55063211
141* MP0000716_abnormal_immune_system0.54774788
142MP0002722_abnormal_immune_system0.54242652

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.41802903
2Focal motor seizures (HP:0011153)4.91670628
3Visual hallucinations (HP:0002367)4.84282396
4Focal seizures (HP:0007359)4.82067899
5Action tremor (HP:0002345)4.61113387
6Eczematoid dermatitis (HP:0000976)4.37848459
7Progressive cerebellar ataxia (HP:0002073)3.94601691
8Dysmetric saccades (HP:0000641)3.82614536
9Febrile seizures (HP:0002373)3.66330325
10Hemiplegia (HP:0002301)3.56143807
11Annular pancreas (HP:0001734)3.52142217
12Atonic seizures (HP:0010819)3.48980165
13Impaired smooth pursuit (HP:0007772)3.46965911
14Abnormality of the lower motor neuron (HP:0002366)3.41407012
15Supranuclear gaze palsy (HP:0000605)3.37540941
16Gaze-evoked nystagmus (HP:0000640)3.29246451
17Epileptic encephalopathy (HP:0200134)3.20261798
18Recurrent abscess formation (HP:0002722)3.19339131
19Diplopia (HP:0000651)3.18693019
20Abnormality of binocular vision (HP:0011514)3.18693019
21Poor eye contact (HP:0000817)3.15786351
22Abnormality of ocular smooth pursuit (HP:0000617)3.12869459
23Abnormal social behavior (HP:0012433)3.12657627
24Impaired social interactions (HP:0000735)3.12657627
25Recurrent bacterial skin infections (HP:0005406)3.10110816
26Absence seizures (HP:0002121)3.05967379
27Depression (HP:0000716)3.00660036
28Truncal ataxia (HP:0002078)2.99688830
29Cellulitis (HP:0100658)2.99269372
30Pointed chin (HP:0000307)2.95873780
31Dysmetria (HP:0001310)2.94654967
32Hyperacusis (HP:0010780)2.94523253
33Abnormality of macrophages (HP:0004311)2.92791806
34Papilledema (HP:0001085)2.91638421
35Myositis (HP:0100614)2.86923243
36Bundle branch block (HP:0011710)2.86734817
37Insomnia (HP:0100785)2.86391694
38Impaired vibration sensation in the lower limbs (HP:0002166)2.85593230
39Ventricular fibrillation (HP:0001663)2.84303160
40Postural instability (HP:0002172)2.83303258
41Slow saccadic eye movements (HP:0000514)2.79132047
42Dysdiadochokinesis (HP:0002075)2.78932434
43Generalized tonic-clonic seizures (HP:0002069)2.78755249
44Increased IgE level (HP:0003212)2.76868455
45Genetic anticipation (HP:0003743)2.76771396
46Urinary urgency (HP:0000012)2.70463500
47Dialeptic seizures (HP:0011146)2.68860393
48Scanning speech (HP:0002168)2.67832047
49Ankle clonus (HP:0011448)2.66510399
50Urinary bladder sphincter dysfunction (HP:0002839)2.63952951
51Intention tremor (HP:0002080)2.63837124
52Chronic obstructive pulmonary disease (HP:0006510)2.59920679
53Obstructive lung disease (HP:0006536)2.59920679
54Spinal canal stenosis (HP:0003416)2.55921857
55Recurrent fungal infections (HP:0002841)2.52926707
56Neurofibrillary tangles (HP:0002185)2.51120930
57Meningitis (HP:0001287)2.50537549
58Elevated erythrocyte sedimentation rate (HP:0003565)2.50248928
59Status epilepticus (HP:0002133)2.48018320
60Broad-based gait (HP:0002136)2.46839621
61Prolonged bleeding time (HP:0003010)2.46410974
62Lower limb asymmetry (HP:0100559)2.39802494
63Neuronal loss in central nervous system (HP:0002529)2.35907886
64Polygenic inheritance (HP:0010982)2.35574169
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.34726372
66Gastrointestinal inflammation (HP:0004386)2.34589387
67Macroorchidism (HP:0000053)2.34379459
68Stereotypic behavior (HP:0000733)2.32318379
69Spontaneous hematomas (HP:0007420)2.31529519
70Mediastinal lymphadenopathy (HP:0100721)2.30562803
71Gingivitis (HP:0000230)2.29704130
72Abnormality of saccadic eye movements (HP:0000570)2.28624285
73Hemiparesis (HP:0001269)2.28557772
74Colitis (HP:0002583)2.27097846
75Orchitis (HP:0100796)2.23863959
76Pustule (HP:0200039)2.23730317
77Distal lower limb amyotrophy (HP:0008944)2.21840510
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.21409614
79Recurrent gram-negative bacterial infections (HP:0005420)2.20755635
80Mutism (HP:0002300)2.17934993
81Spastic gait (HP:0002064)2.17401855
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.17008578
83Inflammation of the large intestine (HP:0002037)2.16043027
84Cerebral aneurysm (HP:0004944)2.15727554
85Stomatitis (HP:0010280)2.11722511
86Peripheral hypomyelination (HP:0007182)2.11100391
87Gastrointestinal infarctions (HP:0005244)2.10929161
88Recurrent skin infections (HP:0001581)2.10601733
89Bradykinesia (HP:0002067)2.09600858
90Chest pain (HP:0100749)2.07158996
91Rapidly progressive (HP:0003678)2.05177515
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04488110
93Abnormal eating behavior (HP:0100738)2.03910601
94Dysostosis multiplex (HP:0000943)2.03589216
95Agammaglobulinemia (HP:0004432)2.03235363
96Elfin facies (HP:0004428)2.01490221
97Impaired vibratory sensation (HP:0002495)2.01450884
98Distal upper limb amyotrophy (HP:0007149)2.00750191
99Upper limb amyotrophy (HP:0009129)2.00750191
100Amyloidosis (HP:0011034)2.00200039
101Anxiety (HP:0000739)2.00092437
102Apathy (HP:0000741)1.98783385
103Recurrent viral infections (HP:0004429)1.97834909
104Ocular albinism (HP:0001107)1.96527213
105Resting tremor (HP:0002322)1.95983046
106Chronic mucocutaneous candidiasis (HP:0002728)1.95427721
107Recurrent cutaneous fungal infections (HP:0011370)1.95427721
108Insidious onset (HP:0003587)1.95325405
109Termporal pattern (HP:0011008)1.95325405
110Distal lower limb muscle weakness (HP:0009053)1.94915442
111Postural tremor (HP:0002174)1.94654011
112Broad face (HP:0000283)1.93944569
113Epistaxis (HP:0000421)1.92912823
114Achilles tendon contracture (HP:0001771)1.92911915
115Lower limb amyotrophy (HP:0007210)1.90919459
116Limb ataxia (HP:0002070)1.89626581
117Hand muscle atrophy (HP:0009130)1.87619240
118Retrobulbar optic neuritis (HP:0100654)1.86423643
119Optic neuritis (HP:0100653)1.86423643
120Global brain atrophy (HP:0002283)1.85825979
121Psychosis (HP:0000709)1.83238317
122Vertebral arch anomaly (HP:0008438)1.82621374
123Abnormality of the periventricular white matter (HP:0002518)1.82527283
124Exercise-induced myalgia (HP:0003738)1.82522805
125Deep palmar crease (HP:0006191)1.80962219
126Encephalitis (HP:0002383)1.80641112
127Gait ataxia (HP:0002066)1.80172778
128Neoplasm of the heart (HP:0100544)1.79447989
129Hypercortisolism (HP:0001578)1.79444348
130Amyotrophic lateral sclerosis (HP:0007354)1.79017161
131Hypochromic anemia (HP:0001931)1.78929664
132Tetraplegia (HP:0002445)1.78294138
133Difficulty running (HP:0009046)1.77591926
134Amblyopia (HP:0000646)1.77553885
135Diminished motivation (HP:0000745)1.77513426
136Vasculitis (HP:0002633)1.76771534
137Increased variability in muscle fiber diameter (HP:0003557)1.75978890
138Rigidity (HP:0002063)1.74380807
139Abnormality of skeletal muscle fiber size (HP:0012084)1.73782563
140Iris hypopigmentation (HP:0007730)1.73552638
141Increased cerebral lipofuscin (HP:0011813)1.73464586
142Loss of speech (HP:0002371)1.73433386
143Easy fatigability (HP:0003388)1.73007216
144Obstructive sleep apnea (HP:0002870)1.72386897
145Abnormality of the fingertips (HP:0001211)1.72352016
146Verrucae (HP:0200043)1.72120707
147Papilloma (HP:0012740)1.72120707
148Abnormality of the Achilles tendon (HP:0005109)1.70102046
149Myotonia (HP:0002486)1.68219235
150Clonus (HP:0002169)1.65823530
151Cerebral inclusion bodies (HP:0100314)1.64455611
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63200633
153Chronic otitis media (HP:0000389)1.63106729
154Overriding aorta (HP:0002623)1.62714226
155Panhypogammaglobulinemia (HP:0003139)1.62530926
156Heterotopia (HP:0002282)1.62330155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.71127678
2NTRK33.13101379
3DAPK22.77219961
4RIPK42.74771526
5KSR22.56168347
6CAMKK12.50793643
7TRIB32.47657033
8ERN12.37037766
9SIK22.29992817
10EPHA42.15854998
11PAK62.11575767
12PRKD32.07102718
13RIPK12.04123612
14MINK11.97629921
15PKN21.97252222
16EEF2K1.96521803
17SMG11.94505354
18MAP2K31.76842251
19MAP3K131.75582428
20SIK11.75078886
21MAP4K11.71173234
22MAP3K111.69098411
23FES1.67073017
24TAOK11.65062945
25ALK1.63534877
26CAMKK21.62959762
27MAP3K41.61000229
28DAPK11.58920038
29STK381.54298274
30PRKCH1.54035233
31MAP3K71.47324989
32RET1.38908308
33TYRO31.37846822
34NTRK11.37391386
35NTRK21.33048212
36MAP3K21.28091684
37PDK11.27531803
38MAP2K41.22527589
39CDK51.21450898
40LMTK21.21031719
41CAMK11.16945166
42SGK31.14892396
43IRAK41.13031411
44CDK121.10443077
45BLK1.08473737
46GRK61.07064410
47BTK1.05560147
48STK111.04512120
49CDK191.04442432
50TAOK21.03830255
51CAMK1G1.03519817
52PTK61.02589339
53SIK31.01318653
54ARAF1.00607393
55MAP3K101.00157630
56CSK0.98373826
57MARK20.96761408
58PRPF4B0.95881092
59SCYL20.93533892
60PDPK10.93441889
61TNK20.88703215
62KSR10.88328342
63MAP3K10.86995274
64TBK10.85266660
65CAMK40.83963885
66JAK10.81413716
67GRK50.78514065
68PTK2B0.77398635
69JAK20.77244541
70SYK0.75823528
71MAP3K30.75484170
72DMPK0.75324502
73RAF10.75304408
74HCK0.75079301
75PRKCG0.74426129
76IRAK20.73009595
77UHMK10.71430579
78WNK10.71345093
79JAK30.70619665
80TESK20.70053002
81MAP3K140.69192344
82MAP2K70.68662628
83SGK20.68422659
84MAP3K120.65234132
85PRKG20.64538413
86ITK0.63036565
87FYN0.62737589
88MAPK70.62073386
89RPS6KA20.60172740
90ZAP700.59813888
91NEK60.59667951
92CDK150.59252212
93FGFR30.59034525
94CDC42BPA0.59018405
95TESK10.58667845
96MARK10.57800368
97MAP2K20.57753259
98MAPK120.56684264
99BMX0.54927480
100IRAK30.54628077
101SGK4940.54419063
102SGK2230.54419063
103CDK180.54298101
104SGK10.54014043
105CDK11A0.53716192
106IKBKE0.53524724
107HIPK20.52464857
108CSF1R0.50010760
109RPS6KC10.49897326
110RPS6KL10.49897326
111EPHB10.49824720
112MAP2K60.49620586
113MAPK110.48504708
114RPS6KA30.47364087
115MAPK40.46669764
116CDK140.46553546
117BMPR20.45742820
118ICK0.45306598
119PTK20.45125527
120TYK20.45021124
121LCK0.44314417
122PDGFRB0.43891655
123PRKD20.43322852
124DAPK30.43287839
125TXK0.42930170
126PHKG20.42855817
127PHKG10.42855817
128LYN0.42507437
129PINK10.42347461
130MAP3K60.41916033
131SRC0.40915461
132PDGFRA0.40686070
133MAPK100.40300020
134FGFR40.40251162
135TTN0.39197533
136CAMK1D0.38693903

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.54396528
2Synaptic vesicle cycle_Homo sapiens_hsa047212.44158335
3Nicotine addiction_Homo sapiens_hsa050332.33092052
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27321913
5Glutamatergic synapse_Homo sapiens_hsa047242.14707054
6Circadian entrainment_Homo sapiens_hsa047132.13741564
7Olfactory transduction_Homo sapiens_hsa047402.10888090
8Salivary secretion_Homo sapiens_hsa049702.04798129
9Gastric acid secretion_Homo sapiens_hsa049711.93182934
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91783607
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85519623
12Morphine addiction_Homo sapiens_hsa050321.83311074
13Amphetamine addiction_Homo sapiens_hsa050311.72521074
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71910710
15GABAergic synapse_Homo sapiens_hsa047271.70876924
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66013331
17Insulin secretion_Homo sapiens_hsa049111.60055518
18* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59578073
19Cholinergic synapse_Homo sapiens_hsa047251.59194870
20Long-term depression_Homo sapiens_hsa047301.58459894
21Dopaminergic synapse_Homo sapiens_hsa047281.56829214
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56583263
23Oxytocin signaling pathway_Homo sapiens_hsa049211.55842901
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55666092
25Type II diabetes mellitus_Homo sapiens_hsa049301.48875041
26GnRH signaling pathway_Homo sapiens_hsa049121.41859144
27Leishmaniasis_Homo sapiens_hsa051401.41740257
28Other glycan degradation_Homo sapiens_hsa005111.40941457
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40557470
30Nitrogen metabolism_Homo sapiens_hsa009101.37992188
31Glioma_Homo sapiens_hsa052141.37803129
32Estrogen signaling pathway_Homo sapiens_hsa049151.30542961
33Calcium signaling pathway_Homo sapiens_hsa040201.30114754
34Renin secretion_Homo sapiens_hsa049241.25057826
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24659034
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24464871
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24410227
38VEGF signaling pathway_Homo sapiens_hsa043701.22840817
39Taste transduction_Homo sapiens_hsa047421.20042667
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.18877417
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13004618
42mTOR signaling pathway_Homo sapiens_hsa041501.11986563
43cAMP signaling pathway_Homo sapiens_hsa040241.11666603
44Gap junction_Homo sapiens_hsa045401.09679845
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07957772
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07934575
47* Phospholipase D signaling pathway_Homo sapiens_hsa040721.07642760
48B cell receptor signaling pathway_Homo sapiens_hsa046621.06254678
49Dorso-ventral axis formation_Homo sapiens_hsa043201.05338036
50Non-small cell lung cancer_Homo sapiens_hsa052231.04375427
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03406948
52Pancreatic secretion_Homo sapiens_hsa049721.02591504
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01224655
54T cell receptor signaling pathway_Homo sapiens_hsa046601.00597573
55ErbB signaling pathway_Homo sapiens_hsa040120.99098719
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94559575
57Inositol phosphate metabolism_Homo sapiens_hsa005620.93121849
58Platelet activation_Homo sapiens_hsa046110.90696462
59Notch signaling pathway_Homo sapiens_hsa043300.89778779
60Chemokine signaling pathway_Homo sapiens_hsa040620.88715766
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86122662
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85439256
63Toxoplasmosis_Homo sapiens_hsa051450.84661234
64Thyroid hormone synthesis_Homo sapiens_hsa049180.83959275
65Endocytosis_Homo sapiens_hsa041440.82716303
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.81104809
67Osteoclast differentiation_Homo sapiens_hsa043800.80835695
68Chronic myeloid leukemia_Homo sapiens_hsa052200.79489255
69Cocaine addiction_Homo sapiens_hsa050300.78917420
70MAPK signaling pathway_Homo sapiens_hsa040100.78789487
71* Choline metabolism in cancer_Homo sapiens_hsa052310.77517975
72Melanogenesis_Homo sapiens_hsa049160.76853770
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76316378
74Endometrial cancer_Homo sapiens_hsa052130.75774937
75Hepatitis B_Homo sapiens_hsa051610.75519736
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74873275
77Hepatitis C_Homo sapiens_hsa051600.74247032
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73717037
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73224912
80Oocyte meiosis_Homo sapiens_hsa041140.72413995
81TNF signaling pathway_Homo sapiens_hsa046680.72333739
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72200989
83Rap1 signaling pathway_Homo sapiens_hsa040150.71681482
84Graft-versus-host disease_Homo sapiens_hsa053320.71527951
85Serotonergic synapse_Homo sapiens_hsa047260.71282289
86Dilated cardiomyopathy_Homo sapiens_hsa054140.71189756
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.70924401
88Influenza A_Homo sapiens_hsa051640.70696490
89Primary immunodeficiency_Homo sapiens_hsa053400.70292216
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70031266
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68416346
92Allograft rejection_Homo sapiens_hsa053300.68013205
93Prion diseases_Homo sapiens_hsa050200.67623685
94Bile secretion_Homo sapiens_hsa049760.66768561
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.66474056
96Measles_Homo sapiens_hsa051620.66329416
97Prolactin signaling pathway_Homo sapiens_hsa049170.66127753
98Insulin signaling pathway_Homo sapiens_hsa049100.65751019
99Acute myeloid leukemia_Homo sapiens_hsa052210.65467700
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65314736
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.65132048
102Staphylococcus aureus infection_Homo sapiens_hsa051500.62915122
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61914200
104Autoimmune thyroid disease_Homo sapiens_hsa053200.61676800
105Glucagon signaling pathway_Homo sapiens_hsa049220.61356562
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.60457894
107African trypanosomiasis_Homo sapiens_hsa051430.59023257
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57656488
109Renal cell carcinoma_Homo sapiens_hsa052110.54719543
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54166410
111Colorectal cancer_Homo sapiens_hsa052100.51109706
112Insulin resistance_Homo sapiens_hsa049310.50997091
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50996589
114Pancreatic cancer_Homo sapiens_hsa052120.50111602
115HIF-1 signaling pathway_Homo sapiens_hsa040660.48640550
116Collecting duct acid secretion_Homo sapiens_hsa049660.47782229
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46774405
118Tuberculosis_Homo sapiens_hsa051520.46284738
119Proteoglycans in cancer_Homo sapiens_hsa052050.45713591
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.44118962
121Salmonella infection_Homo sapiens_hsa051320.43926026
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41963713
123Ras signaling pathway_Homo sapiens_hsa040140.41741146

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