ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytoplasmic mRNA processing body assembly (GO:0033962)	8.29342531
2	mitotic G1 DNA damage checkpoint (GO:0031571)	6.44254806
3	mitotic G1/S transition checkpoint (GO:0044819)	6.28258006
4	G1 DNA damage checkpoint (GO:0044783)	5.68033745
5	mitotic cell cycle arrest (GO:0071850)	5.63680189
6	glucocorticoid biosynthetic process (GO:0006704)	5.50660623
7	natural killer cell differentiation (GO:0001779)	5.41315112
8	RNA destabilization (GO:0050779)	5.25637442
9	negative regulation of glucose import (GO:0046325)	5.19598502
10	seminiferous tubule development (GO:0072520)	5.16808094
11	insulin-like growth factor receptor signaling pathway (GO:0048009)	5.05691644
12	autophagic vacuole fusion (GO:0000046)	5.00817157
13	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	4.86346538
14	negative regulation of cell killing (GO:0031342)	4.86346538
15	negative regulation of glucose transport (GO:0010829)	4.74599559
16	musculoskeletal movement (GO:0050881)	4.68630753
17	multicellular organismal movement (GO:0050879)	4.68630753
18	atrioventricular valve morphogenesis (GO:0003181)	4.58594049
19	behavioral response to nicotine (GO:0035095)	4.49064722
20	proximal/distal pattern formation (GO:0009954)	4.49057227
21	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.41525662
22	megakaryocyte development (GO:0035855)	4.39928503
23	cellular protein complex localization (GO:0034629)	4.31776048
24	phosphatidylglycerol biosynthetic process (GO:0006655)	4.31389098
25	maternal behavior (GO:0042711)	4.24906241
26	positive regulation of macrophage differentiation (GO:0045651)	4.17581533
27	startle response (GO:0001964)	4.15382176
28	multicellular organism reproduction (GO:0032504)	4.01529342
29	organelle membrane fusion (GO:0090174)	3.96422548
30	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.94083574
31	Peyers patch development (GO:0048541)	3.89546773
32	mucosal-associated lymphoid tissue development (GO:0048537)	3.89546773
33	response to morphine (GO:0043278)	3.64611054
34	negative regulation of innate immune response (GO:0045824)	3.59990595
35	parental behavior (GO:0060746)	3.58708341
36	negative regulation of interleukin-1 beta production (GO:0032691)	3.57361108
37	sleep (GO:0030431)	3.56444417
38	heart valve formation (GO:0003188)	3.55000770
39	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.38909697
40	response to isoquinoline alkaloid (GO:0014072)	3.38875358
41	positive regulation of p38MAPK cascade (GO:1900745)	3.37143714
42	negative regulation of interleukin-6 production (GO:0032715)	3.33639339
43	positive regulation of vascular permeability (GO:0043117)	3.28336859
44	response to UV-C (GO:0010225)	3.23405992
45	behavioral response to ethanol (GO:0048149)	3.22888874
46	cellular response to exogenous dsRNA (GO:0071360)	3.20031973
47	male sex determination (GO:0030238)	3.18633019
48	rRNA methylation (GO:0031167)	3.12294436
49	pyrimidine dimer repair (GO:0006290)	3.11528973
50	response to food (GO:0032094)	3.08363701
51	negative regulation of B cell apoptotic process (GO:0002903)	3.01038913
52	cellular senescence (GO:0090398)	3.00644148
53	T cell lineage commitment (GO:0002360)	3.00113719
54	pattern specification involved in kidney development (GO:0061004)	24.2098336
55	maintenance of protein location in nucleus (GO:0051457)	2.95923948
56	metanephros development (GO:0001656)	2.94658461
57	protein complex localization (GO:0031503)	2.94015655
58	granulocyte differentiation (GO:0030851)	2.92256332
59	carnitine transmembrane transport (GO:1902603)	2.92191518
60	negative regulation of interleukin-1 production (GO:0032692)	2.92133536
61	glucocorticoid metabolic process (GO:0008211)	2.83556140
62	positive regulation of astrocyte differentiation (GO:0048711)	2.82400591
63	cellular response to lithium ion (GO:0071285)	2.81868557
64	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.81859192
65	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.80452069
66	carnitine shuttle (GO:0006853)	2.78592972
67	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.78103544
68	homeostasis of number of cells within a tissue (GO:0048873)	2.77949507
69	mannosylation (GO:0097502)	2.77909478
70	motile cilium assembly (GO:0044458)	2.77627633
71	regulation of metalloenzyme activity (GO:0048552)	2.77584949
72	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.73174708
73	reproduction (GO:0000003)	2.72907543
74	macroautophagy (GO:0016236)	2.72701205
75	response to muramyl dipeptide (GO:0032495)	2.71692923
76	regulation of telomere maintenance (GO:0032204)	2.70753250
77	trophectodermal cell differentiation (GO:0001829)	2.70044327
78	positive regulation of cholesterol efflux (GO:0010875)	2.70016115
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.68533786
80	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.67151504
81	cardiolipin metabolic process (GO:0032048)	2.62358753
82	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.62197447
83	ventricular septum morphogenesis (GO:0060412)	2.61201626
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.57990962
85	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.57808009
86	carnitine transport (GO:0015879)	2.57647363
87	amino-acid betaine transport (GO:0015838)	2.57647363
88	cellular extravasation (GO:0045123)	2.56623323
89	embryonic hemopoiesis (GO:0035162)	2.56560750
90	regulation of macrophage differentiation (GO:0045649)	2.55955060
91	coenzyme A biosynthetic process (GO:0015937)	2.53960799
92	rRNA modification (GO:0000154)	2.51693198
93	regulation of B cell differentiation (GO:0045577)	2.48682047
94	maturation of SSU-rRNA (GO:0030490)	2.47181596
95	iron-sulfur cluster assembly (GO:0016226)	2.46992722
96	metallo-sulfur cluster assembly (GO:0031163)	2.46992722
97	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.45420625
98	single fertilization (GO:0007338)	2.42823587
99	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.42226981
100	segment specification (GO:0007379)	13.8636844

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.50666625
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.46255273
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.34674897
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.34674897
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.34674897
6	SCL_19346495_ChIP-Seq_HPC-7_Human	3.57446646
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.42226124
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.32352230
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.23215512
10	VDR_21846776_ChIP-Seq_THP-1_Human	3.22718793
11	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.74790101
12	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.37539137
13	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.28425182
14	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.17604232
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.10669723
16	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.07649295
17	STAT1_20625510_ChIP-Seq_HELA_Human	2.04508964
18	VDR_24763502_ChIP-Seq_THP-1_Human	2.01393469
19	KDM2B_26808549_Chip-Seq_DND41_Human	1.98839082
20	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.96073964
21	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.93899702
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.88348243
23	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.87444013
24	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.85432136
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.84879368
26	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.82712477
27	TFEB_21752829_ChIP-Seq_HELA_Human	1.82046475
28	UTX_26944678_Chip-Seq_JUKART_Human	1.80339107
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.78098829
30	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.70788243
31	MAF_26560356_Chip-Seq_TH2_Human	1.69629964
32	MAF_26560356_Chip-Seq_TH1_Human	1.69161411
33	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.63414777
34	MYB_26560356_Chip-Seq_TH2_Human	1.61136772
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52723699
36	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.52050706
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.46342992
38	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.43490779
39	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.43343296
40	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.42448766
41	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.40587961
42	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.37671741
43	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.36056006
44	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.35974487
45	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.35346098
46	MYC_22102868_ChIP-Seq_BL_Human	1.34874931
47	BCL6_27268052_Chip-Seq_Bcells_Human	1.33992971
48	LXR_22292898_ChIP-Seq_THP-1_Human	1.33971299
49	SPI1_23547873_ChIP-Seq_NB4_Human	1.33573883
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.30508218
51	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.29716949
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.28317888
53	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.27492737
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26964715
55	P68_20966046_ChIP-Seq_HELA_Human	1.25984523
56	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.23502710
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23125153
58	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.21525716
59	GATA3_26560356_Chip-Seq_TH2_Human	1.20505814
60	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19774596
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.19355536
62	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.17949848
63	CIITA_25753668_ChIP-Seq_RAJI_Human	1.17246139
64	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.15627897
65	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.14973890
66	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.13226289
67	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.12421122
68	SPI1_23127762_ChIP-Seq_K562_Human	1.11453914
69	MYB_26560356_Chip-Seq_TH1_Human	1.11336244
70	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.11114453
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10733931
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.10478106
73	SMC4_20622854_ChIP-Seq_HELA_Human	1.10272541
74	TCF7_22412390_ChIP-Seq_EML_Mouse	1.10029206
75	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09420244
76	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.09241301
77	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.07860347
78	P300_27268052_Chip-Seq_Bcells_Human	1.07745479
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06970576
80	VDR_24787735_ChIP-Seq_THP-1_Human	1.03810717
81	BCOR_27268052_Chip-Seq_Bcells_Human	1.02490561
82	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.01419289
83	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99928862
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98877181
85	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.96200339
86	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93737411
87	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.93711441
88	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93509887
89	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93470262
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92714547
91	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.91602646
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.91443270
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91443270
94	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90606345
95	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.90322727
96	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90287520
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89661716
98	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88942142
99	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88869698
100	GATA3_27048872_Chip-Seq_THYMUS_Human	0.88280767

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003941_abnormal_skin_development	4.69431888
2	MP0003191_abnormal_cellular_cholesterol	4.60024911
3	MP0005397_hematopoietic_system_phenotyp	3.23115309
4	MP0001545_abnormal_hematopoietic_system	3.23115309
5	MP0009278_abnormal_bone_marrow	3.08770102
6	MP0002876_abnormal_thyroid_physiology	2.95216499
7	MP0003787_abnormal_imprinting	2.60999451
8	MP0003329_amyloid_beta_deposits	2.56977993
9	MP0005367_renal/urinary_system_phenotyp	2.53254282
10	MP0000516_abnormal_urinary_system	2.53254282
11	MP0002653_abnormal_ependyma_morphology	2.45758268
12	MP0005248_abnormal_Harderian_gland	2.40115141
13	MP0001984_abnormal_olfaction	2.39578176
14	MP0002254_reproductive_system_inflammat	2.35793399
15	MP0003183_abnormal_peptide_metabolism	2.18733374
16	MP0003436_decreased_susceptibility_to	2.14986294
17	MP0000858_altered_metastatic_potential	2.08609608
18	MP0001958_emphysema	2.08241235
19	MP0005501_abnormal_skin_physiology	2.02991372
20	MP0003879_abnormal_hair_cell	1.92226796
21	MP0005076_abnormal_cell_differentiation	1.88807930
22	MP0005058_abnormal_lysosome_morphology	1.84624301
23	MP0000604_amyloidosis	1.84583433
24	MP0003385_abnormal_body_wall	1.81517518
25	MP0003959_abnormal_lean_body	1.81514537
26	MP0002396_abnormal_hematopoietic_system	1.75955090
27	MP0002009_preneoplasia	1.74972912
28	MP0005310_abnormal_salivary_gland	1.73963395
29	MP0009840_abnormal_foam_cell	1.73840679
30	MP0004808_abnormal_hematopoietic_stem	1.68460482
31	MP0005671_abnormal_response_to	1.63272998
32	MP0002419_abnormal_innate_immunity	1.61509027
33	MP0000465_gastrointestinal_hemorrhage	1.56446988
34	MP0009379_abnormal_foot_pigmentation	1.51379121
35	MP0008007_abnormal_cellular_replicative	1.50129566
36	MP0003806_abnormal_nucleotide_metabolis	1.47359048
37	MP0008877_abnormal_DNA_methylation	1.46204456
38	MP0010307_abnormal_tumor_latency	1.45746777
39	MP0003763_abnormal_thymus_physiology	1.45698509
40	MP0002723_abnormal_immune_serum	1.45042558
41	MP0005000_abnormal_immune_tolerance	1.41573273
42	MP0005666_abnormal_adipose_tissue	1.39650282
43	MP0005025_abnormal_response_to	1.38813072
44	MP0004185_abnormal_adipocyte_glucose	1.37268707
45	MP0001800_abnormal_humoral_immune	1.34261118
46	MP0001819_abnormal_immune_cell	1.34197344
47	MP0002420_abnormal_adaptive_immunity	1.33437902
48	MP0002452_abnormal_antigen_presenting	1.31748891
49	MP0004858_abnormal_nervous_system	1.29609387
50	MP0001533_abnormal_skeleton_physiology	1.22032690
51	MP0003453_abnormal_keratinocyte_physiol	1.20423873
52	MP0005075_abnormal_melanosome_morpholog	1.17628264
53	MP0000733_abnormal_muscle_development	1.15431555
54	MP0001542_abnormal_bone_strength	1.13325754
55	MP0005464_abnormal_platelet_physiology	1.12551053
56	MP0009764_decreased_sensitivity_to	1.10983965
57	MP0005670_abnormal_white_adipose	1.10552268
58	MP0000490_abnormal_crypts_of	1.10480221
59	MP0001191_abnormal_skin_condition	1.09330784
60	MP0001529_abnormal_vocalization	1.08797861
61	MP0003115_abnormal_respiratory_system	1.07730398
62	MP0002877_abnormal_melanocyte_morpholog	1.07477882
63	MP0002148_abnormal_hypersensitivity_rea	1.07269536
64	MP0002970_abnormal_white_adipose	1.06184900
65	MP0002971_abnormal_brown_adipose	1.05979700
66	MP0003632_abnormal_nervous_system	1.02745780
67	MP0001764_abnormal_homeostasis	1.02274572
68	MP0002722_abnormal_immune_system	0.99479231
69	MP0003724_increased_susceptibility_to	0.98968808
70	MP0002398_abnormal_bone_marrow	0.96756617
71	MP0001986_abnormal_taste_sensitivity	0.92696458
72	MP0002796_impaired_skin_barrier	0.91200752
73	MP0002229_neurodegeneration	0.85977709
74	MP0001881_abnormal_mammary_gland	0.85145379
75	MP0009785_altered_susceptibility_to	0.83416963
76	MP0000716_abnormal_immune_system	0.82409324
77	MP0010155_abnormal_intestine_physiology	0.81949811
78	MP0000689_abnormal_spleen_morphology	0.80120940
79	MP0002405_respiratory_system_inflammati	0.80008367
80	MP0001486_abnormal_startle_reflex	0.78133860
81	MP0009745_abnormal_behavioral_response	0.75321108
82	MP0002277_abnormal_respiratory_mucosa	0.73550788
83	MP0008058_abnormal_DNA_repair	0.71077521
84	MP0009765_abnormal_xenobiotic_induced	0.70995334
85	MP0002006_tumorigenesis	0.70638706
86	MP0009115_abnormal_fat_cell	0.69735773
87	MP0005410_abnormal_fertilization	0.69611547
88	MP0005390_skeleton_phenotype	0.69326617
89	MP0000703_abnormal_thymus_morphology	0.66058873
90	MP0005360_urolithiasis	0.65873696
91	MP0003303_peritoneal_inflammation	0.65871256
92	MP0002822_catalepsy	0.64344987
93	MP0001188_hyperpigmentation	0.63491156
94	MP0003136_yellow_coat_color	0.63161093
95	MP0008469_abnormal_protein_level	0.63109031
96	MP0009931_abnormal_skin_appearance	0.62778220
97	MP0002429_abnormal_blood_cell	0.61421939
98	MP0001879_abnormal_lymphatic_vessel	0.58327042
99	MP0009703_decreased_birth_body	0.57478817
100	MP0008873_increased_physiological_sensi	0.56539254

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	7.86897470
2	Resting tremor (HP:0002322)	5.30287227
3	Hypercortisolism (HP:0001578)	5.10650026
4	J-shaped sella turcica (HP:0002680)	5.04727289
5	Hypochromic microcytic anemia (HP:0004840)	4.25477600
6	Mitral stenosis (HP:0001718)	4.14450101
7	Long toe (HP:0010511)	4.06684434
8	Absent frontal sinuses (HP:0002688)	4.02444615
9	Renal salt wasting (HP:0000127)	3.90462415
10	Split foot (HP:0001839)	3.74172235
11	Hypochromic anemia (HP:0001931)	3.62414970
12	Beaking of vertebral bodies (HP:0004568)	3.43211403
13	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.40126306
14	Postural instability (HP:0002172)	3.20104624
15	Broad distal phalanx of finger (HP:0009836)	3.03184548
16	Shawl scrotum (HP:0000049)	2.94886217
17	Thoracic kyphosis (HP:0002942)	2.94492597
18	Abnormality of the prostate (HP:0008775)	2.94407038
19	Deformed sella turcica (HP:0002681)	2.89645089
20	Exocrine pancreatic insufficiency (HP:0001738)	2.88193926
21	Spinal cord lesions (HP:0100561)	2.87085542
22	Syringomyelia (HP:0003396)	2.87085542
23	Increased muscle lipid content (HP:0009058)	2.81340916
24	Petechiae (HP:0000967)	2.81025518
25	Abnormality of the frontal sinuses (HP:0002687)	2.75480802
26	Hyperparathyroidism (HP:0000843)	2.63252949
27	Adrenal overactivity (HP:0002717)	2.61864540
28	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.61822277
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.60434969
30	Abnormality of the thoracic spine (HP:0100711)	2.59992324
31	Myositis (HP:0100614)	2.55909079
32	Ureteral duplication (HP:0000073)	2.53230027
33	Opisthotonus (HP:0002179)	2.47212544
34	Anhidrosis (HP:0000970)	2.46558954
35	Oligodactyly (hands) (HP:0001180)	2.42492073
36	Abnormality of dental color (HP:0011073)	2.38461283
37	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.33839944
38	Spastic paraparesis (HP:0002313)	2.32767974
39	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.30650144
40	Mucopolysacchariduria (HP:0008155)	2.26436246
41	Urinary glycosaminoglycan excretion (HP:0003541)	2.26436246
42	Abnormal hemoglobin (HP:0011902)	2.21255100
43	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.18932467
44	Abnormality of polysaccharide metabolism (HP:0011012)	2.18932467
45	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.18932467
46	Infantile muscular hypotonia (HP:0008947)	2.17025946
47	Hypoparathyroidism (HP:0000829)	2.16034276
48	Tapered finger (HP:0001182)	2.12255451
49	Horseshoe kidney (HP:0000085)	2.11770215
50	Prostate neoplasm (HP:0100787)	2.11186244
51	Alopecia of scalp (HP:0002293)	2.11140057
52	Deep palmar crease (HP:0006191)	2.09313636
53	Paraparesis (HP:0002385)	2.08475129
54	Erythema (HP:0010783)	2.07732516
55	Hypoplasia of the odontoid process (HP:0003311)	2.05126993
56	Abnormality of glycolipid metabolism (HP:0010969)	2.04181592
57	Abnormality of liposaccharide metabolism (HP:0010968)	2.04181592
58	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.04181592
59	Tented upper lip vermilion (HP:0010804)	1.99876152
60	Vertebral compression fractures (HP:0002953)	1.99791213
61	Lipid accumulation in hepatocytes (HP:0006561)	1.96580127
62	Abnormality of the 2nd finger (HP:0004100)	1.94212152
63	Microretrognathia (HP:0000308)	1.93956842
64	Volvulus (HP:0002580)	1.92802428
65	Increased cerebral lipofuscin (HP:0011813)	1.92499916
66	Ankle clonus (HP:0011448)	1.92108198
67	Dysostosis multiplex (HP:0000943)	1.90986873
68	Progressive microcephaly (HP:0000253)	1.88216479
69	Diminished motivation (HP:0000745)	1.84349840
70	Arterial thrombosis (HP:0004420)	1.81575160
71	3-Methylglutaconic aciduria (HP:0003535)	1.81279634
72	Obstructive lung disease (HP:0006536)	1.81189457
73	Chronic obstructive pulmonary disease (HP:0006510)	1.81189457
74	Seborrheic dermatitis (HP:0001051)	1.79157892
75	Large eyes (HP:0001090)	1.77709629
76	Abnormality of male internal genitalia (HP:0000022)	1.77086149
77	Short clavicles (HP:0000894)	1.76912461
78	Microcytic anemia (HP:0001935)	1.75701460
79	Pendular nystagmus (HP:0012043)	1.75630479
80	Vacuolated lymphocytes (HP:0001922)	1.73425759
81	Medial flaring of the eyebrow (HP:0010747)	1.72193483
82	Severe Myopia (HP:0011003)	1.71014686
83	Congenital malformation of the right heart (HP:0011723)	1.69790130
84	Double outlet right ventricle (HP:0001719)	1.69790130
85	Orchitis (HP:0100796)	1.68918687
86	Aplasia/Hypoplasia of the clavicles (HP:0006710)	1.68591669
87	Spinal muscular atrophy (HP:0007269)	1.67736668
88	Nephrogenic diabetes insipidus (HP:0009806)	1.67622474
89	Abnormality of the pericardium (HP:0001697)	1.67493148
90	Aortic valve stenosis (HP:0001650)	1.65995329
91	Sparse lateral eyebrow (HP:0005338)	1.65512696
92	Dry hair (HP:0011359)	1.63142684
93	Failure to thrive in infancy (HP:0001531)	1.62799728
94	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.62550268
95	Myelodysplasia (HP:0002863)	1.62483455
96	Renal dysplasia (HP:0000110)	1.62460643
97	Pulmonary infiltrates (HP:0002113)	1.61747503
98	Absent eyelashes (HP:0000561)	1.61332061
99	Thrombocytosis (HP:0001894)	1.61153262
100	Chest pain (HP:0100749)	1.61126720

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIM2	8.15075801
2	BMPR1B	4.68039158
3	DYRK1B	4.12865535
4	CDK6	3.87519119
5	TAOK3	3.16039810
6	TGFBR1	2.77937205
7	MAP3K4	2.71710309
8	TBK1	2.64590099
9	CDK8	2.56494074
10	TXK	2.44623628
11	BCKDK	2.39292110
12	IRAK4	2.37479280
13	MAP3K14	2.11058979
14	CDK9	1.95967690
15	MAP3K5	1.92834028
16	EIF2AK3	1.84331903
17	FES	1.74351216
18	MAP2K2	1.36099221
19	PIM1	1.31327296
20	DAPK3	1.20898775
21	TAOK1	1.16793573
22	IKBKB	1.08105090
23	MAP3K13	1.06095905
24	MAP4K1	1.04716768
25	LATS2	1.03156035
26	KIT	1.03052504
27	IKBKE	0.96562655
28	STK39	0.95739559
29	EIF2AK2	0.94558196
30	TAF1	0.92882741
31	BRD4	0.91935387
32	GRK6	0.91736692
33	MOS	0.91649154
34	CAMK2D	0.88406352
35	CAMK2B	0.88051508
36	ABL2	0.87312131
37	PAK2	0.86790319
38	CAMK2G	0.77228688
39	CDK7	0.75476667
40	CDK4	0.75308761
41	MATK	0.75154154
42	CSF1R	0.74211204
43	SIK1	0.73240107
44	PDK2	0.72611288
45	PTK6	0.70275196
46	EPHA2	0.69793474
47	MTOR	0.66819145
48	BTK	0.66097526
49	FLT3	0.63837150
50	MAP2K7	0.61007576
51	HCK	0.61002760
52	SCYL2	0.60972053
53	JAK1	0.59739230
54	ARAF	0.59311115
55	ABL1	0.58890387
56	PAK6	0.58669762
57	CHUK	0.58575505
58	RPS6KA4	0.56808793
59	PDGFRB	0.54898049
60	ZAP70	0.53011513
61	MAP3K6	0.51856060
62	TEC	0.50063461
63	KDR	0.49203005
64	PRKCQ	0.47670272
65	RPS6KA6	0.46593011
66	RPS6KC1	0.46421008
67	RPS6KL1	0.46421008
68	NTRK3	0.45505379
69	PRKD2	0.45464700
70	HIPK2	0.44376757
71	ICK	0.43767908
72	SMG1	0.40133179
73	SIK3	0.36346657
74	MAPK4	0.35874039
75	TESK2	0.34948547
76	SYK	0.34541032
77	TNK2	0.34043029
78	MARK2	0.31833351
79	PRKD3	0.31105615
80	OXSR1	0.29612229
81	CSK	0.29314081
82	IRAK3	0.29119620
83	CHEK1	0.28491743
84	LCK	0.27689521
85	CDK14	0.27442446
86	MAPK14	0.27262806
87	LYN	0.26754644
88	MAP2K6	0.26549970
89	ERN1	0.24298829
90	RPS6KA1	0.23525342
91	MAP2K3	0.23332580
92	MAPKAPK2	0.23068664
93	SIK2	0.23028049
94	CHEK2	0.22110921
95	JAK2	0.21699616
96	WNK4	0.19961150
97	MAPK1	0.19285045
98	STK38L	0.17977829
99	TRIM28	0.17296694
100	PKN2	0.16037572

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	3.18758024
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.14355385
3	Bladder cancer_Homo sapiens_hsa05219	2.81579060
4	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.38486552
5	Basal transcription factors_Homo sapiens_hsa03022	2.30491036
6	Fatty acid elongation_Homo sapiens_hsa00062	2.22645228
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.06670510
8	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.03771653
9	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	2.03492817
10	Sulfur relay system_Homo sapiens_hsa04122	1.99878631
11	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.99760287
12	Lysosome_Homo sapiens_hsa04142	1.84553133
13	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.78604399
14	Acute myeloid leukemia_Homo sapiens_hsa05221	1.78276144
15	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.77832806
16	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.74396848
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69361873
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57994126
19	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.54702308
20	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.54621461
21	Nicotine addiction_Homo sapiens_hsa05033	1.53257328
22	Notch signaling pathway_Homo sapiens_hsa04330	1.49577912
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.48229222
24	p53 signaling pathway_Homo sapiens_hsa04115	1.47255778
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45483036
26	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.44062217
27	Hepatitis C_Homo sapiens_hsa05160	1.40090335
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36092394
29	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.33712951
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.32665635
31	Other glycan degradation_Homo sapiens_hsa00511	1.31872864
32	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.31312824
33	Base excision repair_Homo sapiens_hsa03410	1.23076677
34	Melanoma_Homo sapiens_hsa05218	1.20593996
35	ErbB signaling pathway_Homo sapiens_hsa04012	1.19118969
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.19118079
37	Herpes simplex infection_Homo sapiens_hsa05168	1.18702742
38	Apoptosis_Homo sapiens_hsa04210	1.16211165
39	Shigellosis_Homo sapiens_hsa05131	1.15224472
40	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.11574624
41	Non-small cell lung cancer_Homo sapiens_hsa05223	1.10991715
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09306999
43	RNA degradation_Homo sapiens_hsa03018	1.08269270
44	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.07854191
45	Glioma_Homo sapiens_hsa05214	1.06937124
46	Osteoclast differentiation_Homo sapiens_hsa04380	1.01263260
47	DNA replication_Homo sapiens_hsa03030	1.00340722
48	Measles_Homo sapiens_hsa05162	1.00244234
49	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.97128049
50	Ras signaling pathway_Homo sapiens_hsa04014	0.96420234
51	Leishmaniasis_Homo sapiens_hsa05140	0.96128851
52	Malaria_Homo sapiens_hsa05144	0.95906507
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94273014
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.93727102
55	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.90959852
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88929854
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87962778
58	Hepatitis B_Homo sapiens_hsa05161	0.86484770
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84648898
60	Circadian rhythm_Homo sapiens_hsa04710	0.81101224
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.79260381
62	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.79141431
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74417747
64	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.73292174
65	Purine metabolism_Homo sapiens_hsa00230	0.69834489
66	Platelet activation_Homo sapiens_hsa04611	0.69390880
67	Ribosome_Homo sapiens_hsa03010	0.68338499
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67816512
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.66485980
70	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.66405398
71	MAPK signaling pathway_Homo sapiens_hsa04010	0.63748947
72	Influenza A_Homo sapiens_hsa05164	0.63722052
73	Small cell lung cancer_Homo sapiens_hsa05222	0.61325077
74	Morphine addiction_Homo sapiens_hsa05032	0.59990749
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59049480
76	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.58343463
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58100595
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.53374428
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52883988
80	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.52781416
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52700027
82	Cell cycle_Homo sapiens_hsa04110	0.51590896
83	Cholinergic synapse_Homo sapiens_hsa04725	0.51388090
84	Chemokine signaling pathway_Homo sapiens_hsa04062	0.50423177
85	Prostate cancer_Homo sapiens_hsa05215	0.47151002
86	TNF signaling pathway_Homo sapiens_hsa04668	0.46874785
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.46419897
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44866136
89	Peroxisome_Homo sapiens_hsa04146	0.43291540
90	VEGF signaling pathway_Homo sapiens_hsa04370	0.41960702
91	Phototransduction_Homo sapiens_hsa04744	0.39791533
92	Pancreatic cancer_Homo sapiens_hsa05212	0.39049634
93	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.34413153
94	Legionellosis_Homo sapiens_hsa05134	0.32146667
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31733453
96	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.31528222
97	Caffeine metabolism_Homo sapiens_hsa00232	0.31213190
98	Insulin resistance_Homo sapiens_hsa04931	0.30820006
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.30787256
100	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.29566591

DGKZP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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