DGKZP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)8.29342531
2mitotic G1 DNA damage checkpoint (GO:0031571)6.44254806
3mitotic G1/S transition checkpoint (GO:0044819)6.28258006
4G1 DNA damage checkpoint (GO:0044783)5.68033745
5mitotic cell cycle arrest (GO:0071850)5.63680189
6glucocorticoid biosynthetic process (GO:0006704)5.50660623
7natural killer cell differentiation (GO:0001779)5.41315112
8RNA destabilization (GO:0050779)5.25637442
9negative regulation of glucose import (GO:0046325)5.19598502
10seminiferous tubule development (GO:0072520)5.16808094
11insulin-like growth factor receptor signaling pathway (GO:0048009)5.05691644
12autophagic vacuole fusion (GO:0000046)5.00817157
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86346538
14negative regulation of cell killing (GO:0031342)4.86346538
15negative regulation of glucose transport (GO:0010829)4.74599559
16musculoskeletal movement (GO:0050881)4.68630753
17multicellular organismal movement (GO:0050879)4.68630753
18atrioventricular valve morphogenesis (GO:0003181)4.58594049
19behavioral response to nicotine (GO:0035095)4.49064722
20proximal/distal pattern formation (GO:0009954)4.49057227
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.41525662
22megakaryocyte development (GO:0035855)4.39928503
23cellular protein complex localization (GO:0034629)4.31776048
24phosphatidylglycerol biosynthetic process (GO:0006655)4.31389098
25maternal behavior (GO:0042711)4.24906241
26positive regulation of macrophage differentiation (GO:0045651)4.17581533
27startle response (GO:0001964)4.15382176
28multicellular organism reproduction (GO:0032504)4.01529342
29organelle membrane fusion (GO:0090174)3.96422548
30positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.94083574
31Peyers patch development (GO:0048541)3.89546773
32mucosal-associated lymphoid tissue development (GO:0048537)3.89546773
33response to morphine (GO:0043278)3.64611054
34negative regulation of innate immune response (GO:0045824)3.59990595
35parental behavior (GO:0060746)3.58708341
36negative regulation of interleukin-1 beta production (GO:0032691)3.57361108
37sleep (GO:0030431)3.56444417
38heart valve formation (GO:0003188)3.55000770
39positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.38909697
40response to isoquinoline alkaloid (GO:0014072)3.38875358
41positive regulation of p38MAPK cascade (GO:1900745)3.37143714
42negative regulation of interleukin-6 production (GO:0032715)3.33639339
43positive regulation of vascular permeability (GO:0043117)3.28336859
44response to UV-C (GO:0010225)3.23405992
45behavioral response to ethanol (GO:0048149)3.22888874
46cellular response to exogenous dsRNA (GO:0071360)3.20031973
47male sex determination (GO:0030238)3.18633019
48rRNA methylation (GO:0031167)3.12294436
49pyrimidine dimer repair (GO:0006290)3.11528973
50response to food (GO:0032094)3.08363701
51negative regulation of B cell apoptotic process (GO:0002903)3.01038913
52cellular senescence (GO:0090398)3.00644148
53T cell lineage commitment (GO:0002360)3.00113719
54pattern specification involved in kidney development (GO:0061004)24.2098336
55maintenance of protein location in nucleus (GO:0051457)2.95923948
56metanephros development (GO:0001656)2.94658461
57protein complex localization (GO:0031503)2.94015655
58granulocyte differentiation (GO:0030851)2.92256332
59carnitine transmembrane transport (GO:1902603)2.92191518
60negative regulation of interleukin-1 production (GO:0032692)2.92133536
61glucocorticoid metabolic process (GO:0008211)2.83556140
62positive regulation of astrocyte differentiation (GO:0048711)2.82400591
63cellular response to lithium ion (GO:0071285)2.81868557
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81859192
65negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80452069
66carnitine shuttle (GO:0006853)2.78592972
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.78103544
68homeostasis of number of cells within a tissue (GO:0048873)2.77949507
69mannosylation (GO:0097502)2.77909478
70motile cilium assembly (GO:0044458)2.77627633
71regulation of metalloenzyme activity (GO:0048552)2.77584949
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73174708
73reproduction (GO:0000003)2.72907543
74macroautophagy (GO:0016236)2.72701205
75response to muramyl dipeptide (GO:0032495)2.71692923
76regulation of telomere maintenance (GO:0032204)2.70753250
77trophectodermal cell differentiation (GO:0001829)2.70044327
78positive regulation of cholesterol efflux (GO:0010875)2.70016115
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68533786
80negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67151504
81cardiolipin metabolic process (GO:0032048)2.62358753
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62197447
83ventricular septum morphogenesis (GO:0060412)2.61201626
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57990962
85negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57808009
86amino-acid betaine transport (GO:0015838)2.57647363
87carnitine transport (GO:0015879)2.57647363
88cellular extravasation (GO:0045123)2.56623323
89embryonic hemopoiesis (GO:0035162)2.56560750
90regulation of macrophage differentiation (GO:0045649)2.55955060
91coenzyme A biosynthetic process (GO:0015937)2.53960799
92rRNA modification (GO:0000154)2.51693198
93regulation of B cell differentiation (GO:0045577)2.48682047
94maturation of SSU-rRNA (GO:0030490)2.47181596
95iron-sulfur cluster assembly (GO:0016226)2.46992722
96metallo-sulfur cluster assembly (GO:0031163)2.46992722
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45420625
98single fertilization (GO:0007338)2.42823587
99cell fate commitment involved in formation of primary germ layer (GO:0060795)2.42226981
100segment specification (GO:0007379)13.8636844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.50666625
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.46255273
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.34674897
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.34674897
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.34674897
6SCL_19346495_ChIP-Seq_HPC-7_Human3.57446646
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42226124
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.32352230
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.23215512
10VDR_21846776_ChIP-Seq_THP-1_Human3.22718793
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.74790101
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37539137
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.28425182
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17604232
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10669723
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07649295
17STAT1_20625510_ChIP-Seq_HELA_Human2.04508964
18VDR_24763502_ChIP-Seq_THP-1_Human2.01393469
19KDM2B_26808549_Chip-Seq_DND41_Human1.98839082
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96073964
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93899702
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.88348243
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87444013
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85432136
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84879368
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.82712477
27TFEB_21752829_ChIP-Seq_HELA_Human1.82046475
28UTX_26944678_Chip-Seq_JUKART_Human1.80339107
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78098829
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.70788243
31MAF_26560356_Chip-Seq_TH2_Human1.69629964
32MAF_26560356_Chip-Seq_TH1_Human1.69161411
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63414777
34MYB_26560356_Chip-Seq_TH2_Human1.61136772
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52723699
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.52050706
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46342992
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.43490779
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43343296
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42448766
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40587961
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37671741
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36056006
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35974487
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35346098
46MYC_22102868_ChIP-Seq_BL_Human1.34874931
47BCL6_27268052_Chip-Seq_Bcells_Human1.33992971
48LXR_22292898_ChIP-Seq_THP-1_Human1.33971299
49SPI1_23547873_ChIP-Seq_NB4_Human1.33573883
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30508218
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29716949
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.28317888
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27492737
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26964715
55P68_20966046_ChIP-Seq_HELA_Human1.25984523
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23502710
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23125153
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.21525716
59GATA3_26560356_Chip-Seq_TH2_Human1.20505814
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19774596
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.19355536
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17949848
63CIITA_25753668_ChIP-Seq_RAJI_Human1.17246139
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15627897
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14973890
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13226289
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12421122
68SPI1_23127762_ChIP-Seq_K562_Human1.11453914
69MYB_26560356_Chip-Seq_TH1_Human1.11336244
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11114453
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10733931
72GABP_19822575_ChIP-Seq_HepG2_Human1.10478106
73SMC4_20622854_ChIP-Seq_HELA_Human1.10272541
74TCF7_22412390_ChIP-Seq_EML_Mouse1.10029206
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09420244
76ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09241301
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07860347
78P300_27268052_Chip-Seq_Bcells_Human1.07745479
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06970576
80VDR_24787735_ChIP-Seq_THP-1_Human1.03810717
81BCOR_27268052_Chip-Seq_Bcells_Human1.02490561
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.01419289
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99928862
84IRF1_19129219_ChIP-ChIP_H3396_Human0.98877181
85P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96200339
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93737411
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.93711441
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93509887
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93470262
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.92714547
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91602646
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91443270
93CBP_20019798_ChIP-Seq_JUKART_Human0.91443270
94RUNX_20019798_ChIP-Seq_JUKART_Human0.90606345
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90322727
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90287520
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89661716
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88942142
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88869698
100GATA3_27048872_Chip-Seq_THYMUS_Human0.88280767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.69431888
2MP0003191_abnormal_cellular_cholesterol4.60024911
3MP0001545_abnormal_hematopoietic_system3.23115309
4MP0005397_hematopoietic_system_phenotyp3.23115309
5MP0009278_abnormal_bone_marrow3.08770102
6MP0002876_abnormal_thyroid_physiology2.95216499
7MP0003787_abnormal_imprinting2.60999451
8MP0003329_amyloid_beta_deposits2.56977993
9MP0005367_renal/urinary_system_phenotyp2.53254282
10MP0000516_abnormal_urinary_system2.53254282
11MP0002653_abnormal_ependyma_morphology2.45758268
12MP0005248_abnormal_Harderian_gland2.40115141
13MP0001984_abnormal_olfaction2.39578176
14MP0002254_reproductive_system_inflammat2.35793399
15MP0003183_abnormal_peptide_metabolism2.18733374
16MP0003436_decreased_susceptibility_to2.14986294
17MP0000858_altered_metastatic_potential2.08609608
18MP0001958_emphysema2.08241235
19MP0005501_abnormal_skin_physiology2.02991372
20MP0003879_abnormal_hair_cell1.92226796
21MP0005076_abnormal_cell_differentiation1.88807930
22MP0005058_abnormal_lysosome_morphology1.84624301
23MP0000604_amyloidosis1.84583433
24MP0003385_abnormal_body_wall1.81517518
25MP0003959_abnormal_lean_body1.81514537
26MP0002396_abnormal_hematopoietic_system1.75955090
27MP0002009_preneoplasia1.74972912
28MP0005310_abnormal_salivary_gland1.73963395
29MP0009840_abnormal_foam_cell1.73840679
30MP0004808_abnormal_hematopoietic_stem1.68460482
31MP0005671_abnormal_response_to1.63272998
32MP0002419_abnormal_innate_immunity1.61509027
33MP0000465_gastrointestinal_hemorrhage1.56446988
34MP0009379_abnormal_foot_pigmentation1.51379121
35MP0008007_abnormal_cellular_replicative1.50129566
36MP0003806_abnormal_nucleotide_metabolis1.47359048
37MP0008877_abnormal_DNA_methylation1.46204456
38MP0010307_abnormal_tumor_latency1.45746777
39MP0003763_abnormal_thymus_physiology1.45698509
40MP0002723_abnormal_immune_serum1.45042558
41MP0005000_abnormal_immune_tolerance1.41573273
42MP0005666_abnormal_adipose_tissue1.39650282
43MP0005025_abnormal_response_to1.38813072
44MP0004185_abnormal_adipocyte_glucose1.37268707
45MP0001800_abnormal_humoral_immune1.34261118
46MP0001819_abnormal_immune_cell1.34197344
47MP0002420_abnormal_adaptive_immunity1.33437902
48MP0002452_abnormal_antigen_presenting1.31748891
49MP0004858_abnormal_nervous_system1.29609387
50MP0001533_abnormal_skeleton_physiology1.22032690
51MP0003453_abnormal_keratinocyte_physiol1.20423873
52MP0005075_abnormal_melanosome_morpholog1.17628264
53MP0000733_abnormal_muscle_development1.15431555
54MP0001542_abnormal_bone_strength1.13325754
55MP0005464_abnormal_platelet_physiology1.12551053
56MP0009764_decreased_sensitivity_to1.10983965
57MP0005670_abnormal_white_adipose1.10552268
58MP0000490_abnormal_crypts_of1.10480221
59MP0001191_abnormal_skin_condition1.09330784
60MP0001529_abnormal_vocalization1.08797861
61MP0003115_abnormal_respiratory_system1.07730398
62MP0002877_abnormal_melanocyte_morpholog1.07477882
63MP0002148_abnormal_hypersensitivity_rea1.07269536
64MP0002970_abnormal_white_adipose1.06184900
65MP0002971_abnormal_brown_adipose1.05979700
66MP0003632_abnormal_nervous_system1.02745780
67MP0001764_abnormal_homeostasis1.02274572
68MP0002722_abnormal_immune_system0.99479231
69MP0003724_increased_susceptibility_to0.98968808
70MP0002398_abnormal_bone_marrow0.96756617
71MP0001986_abnormal_taste_sensitivity0.92696458
72MP0002796_impaired_skin_barrier0.91200752
73MP0002229_neurodegeneration0.85977709
74MP0001881_abnormal_mammary_gland0.85145379
75MP0009785_altered_susceptibility_to0.83416963
76MP0000716_abnormal_immune_system0.82409324
77MP0010155_abnormal_intestine_physiology0.81949811
78MP0000689_abnormal_spleen_morphology0.80120940
79MP0002405_respiratory_system_inflammati0.80008367
80MP0001486_abnormal_startle_reflex0.78133860
81MP0009745_abnormal_behavioral_response0.75321108
82MP0002277_abnormal_respiratory_mucosa0.73550788
83MP0008058_abnormal_DNA_repair0.71077521
84MP0009765_abnormal_xenobiotic_induced0.70995334
85MP0002006_tumorigenesis0.70638706
86MP0009115_abnormal_fat_cell0.69735773
87MP0005410_abnormal_fertilization0.69611547
88MP0005390_skeleton_phenotype0.69326617
89MP0000703_abnormal_thymus_morphology0.66058873
90MP0005360_urolithiasis0.65873696
91MP0003303_peritoneal_inflammation0.65871256
92MP0002822_catalepsy0.64344987
93MP0001188_hyperpigmentation0.63491156
94MP0003136_yellow_coat_color0.63161093
95MP0008469_abnormal_protein_level0.63109031
96MP0009931_abnormal_skin_appearance0.62778220
97MP0002429_abnormal_blood_cell0.61421939
98MP0001879_abnormal_lymphatic_vessel0.58327042
99MP0009703_decreased_birth_body0.57478817
100MP0008873_increased_physiological_sensi0.56539254

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.86897470
2Resting tremor (HP:0002322)5.30287227
3Hypercortisolism (HP:0001578)5.10650026
4J-shaped sella turcica (HP:0002680)5.04727289
5Hypochromic microcytic anemia (HP:0004840)4.25477600
6Mitral stenosis (HP:0001718)4.14450101
7Long toe (HP:0010511)4.06684434
8Absent frontal sinuses (HP:0002688)4.02444615
9Renal salt wasting (HP:0000127)3.90462415
10Split foot (HP:0001839)3.74172235
11Hypochromic anemia (HP:0001931)3.62414970
12Beaking of vertebral bodies (HP:0004568)3.43211403
13Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.40126306
14Postural instability (HP:0002172)3.20104624
15Broad distal phalanx of finger (HP:0009836)3.03184548
16Shawl scrotum (HP:0000049)2.94886217
17Thoracic kyphosis (HP:0002942)2.94492597
18Abnormality of the prostate (HP:0008775)2.94407038
19Deformed sella turcica (HP:0002681)2.89645089
20Exocrine pancreatic insufficiency (HP:0001738)2.88193926
21Spinal cord lesions (HP:0100561)2.87085542
22Syringomyelia (HP:0003396)2.87085542
23Increased muscle lipid content (HP:0009058)2.81340916
24Petechiae (HP:0000967)2.81025518
25Abnormality of the frontal sinuses (HP:0002687)2.75480802
26Hyperparathyroidism (HP:0000843)2.63252949
27Adrenal overactivity (HP:0002717)2.61864540
28Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.61822277
29Elevated erythrocyte sedimentation rate (HP:0003565)2.60434969
30Abnormality of the thoracic spine (HP:0100711)2.59992324
31Myositis (HP:0100614)2.55909079
32Ureteral duplication (HP:0000073)2.53230027
33Opisthotonus (HP:0002179)2.47212544
34Anhidrosis (HP:0000970)2.46558954
35Oligodactyly (hands) (HP:0001180)2.42492073
36Abnormality of dental color (HP:0011073)2.38461283
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.33839944
38Spastic paraparesis (HP:0002313)2.32767974
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30650144
40Mucopolysacchariduria (HP:0008155)2.26436246
41Urinary glycosaminoglycan excretion (HP:0003541)2.26436246
42Abnormal hemoglobin (HP:0011902)2.21255100
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18932467
44Abnormality of polysaccharide metabolism (HP:0011012)2.18932467
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18932467
46Infantile muscular hypotonia (HP:0008947)2.17025946
47Hypoparathyroidism (HP:0000829)2.16034276
48Tapered finger (HP:0001182)2.12255451
49Horseshoe kidney (HP:0000085)2.11770215
50Prostate neoplasm (HP:0100787)2.11186244
51Alopecia of scalp (HP:0002293)2.11140057
52Deep palmar crease (HP:0006191)2.09313636
53Paraparesis (HP:0002385)2.08475129
54Erythema (HP:0010783)2.07732516
55Hypoplasia of the odontoid process (HP:0003311)2.05126993
56Abnormality of glycolipid metabolism (HP:0010969)2.04181592
57Abnormality of liposaccharide metabolism (HP:0010968)2.04181592
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.04181592
59Tented upper lip vermilion (HP:0010804)1.99876152
60Vertebral compression fractures (HP:0002953)1.99791213
61Lipid accumulation in hepatocytes (HP:0006561)1.96580127
62Abnormality of the 2nd finger (HP:0004100)1.94212152
63Microretrognathia (HP:0000308)1.93956842
64Volvulus (HP:0002580)1.92802428
65Increased cerebral lipofuscin (HP:0011813)1.92499916
66Ankle clonus (HP:0011448)1.92108198
67Dysostosis multiplex (HP:0000943)1.90986873
68Progressive microcephaly (HP:0000253)1.88216479
69Diminished motivation (HP:0000745)1.84349840
70Arterial thrombosis (HP:0004420)1.81575160
713-Methylglutaconic aciduria (HP:0003535)1.81279634
72Obstructive lung disease (HP:0006536)1.81189457
73Chronic obstructive pulmonary disease (HP:0006510)1.81189457
74Seborrheic dermatitis (HP:0001051)1.79157892
75Large eyes (HP:0001090)1.77709629
76Abnormality of male internal genitalia (HP:0000022)1.77086149
77Short clavicles (HP:0000894)1.76912461
78Microcytic anemia (HP:0001935)1.75701460
79Pendular nystagmus (HP:0012043)1.75630479
80Vacuolated lymphocytes (HP:0001922)1.73425759
81Medial flaring of the eyebrow (HP:0010747)1.72193483
82Severe Myopia (HP:0011003)1.71014686
83Congenital malformation of the right heart (HP:0011723)1.69790130
84Double outlet right ventricle (HP:0001719)1.69790130
85Orchitis (HP:0100796)1.68918687
86Aplasia/Hypoplasia of the clavicles (HP:0006710)1.68591669
87Spinal muscular atrophy (HP:0007269)1.67736668
88Nephrogenic diabetes insipidus (HP:0009806)1.67622474
89Abnormality of the pericardium (HP:0001697)1.67493148
90Aortic valve stenosis (HP:0001650)1.65995329
91Sparse lateral eyebrow (HP:0005338)1.65512696
92Dry hair (HP:0011359)1.63142684
93Failure to thrive in infancy (HP:0001531)1.62799728
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.62550268
95Myelodysplasia (HP:0002863)1.62483455
96Renal dysplasia (HP:0000110)1.62460643
97Pulmonary infiltrates (HP:0002113)1.61747503
98Absent eyelashes (HP:0000561)1.61332061
99Thrombocytosis (HP:0001894)1.61153262
100Chest pain (HP:0100749)1.61126720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM28.15075801
2BMPR1B4.68039158
3DYRK1B4.12865535
4CDK63.87519119
5TAOK33.16039810
6TGFBR12.77937205
7MAP3K42.71710309
8TBK12.64590099
9CDK82.56494074
10TXK2.44623628
11BCKDK2.39292110
12IRAK42.37479280
13MAP3K142.11058979
14CDK91.95967690
15MAP3K51.92834028
16EIF2AK31.84331903
17FES1.74351216
18MAP2K21.36099221
19PIM11.31327296
20DAPK31.20898775
21TAOK11.16793573
22IKBKB1.08105090
23MAP3K131.06095905
24MAP4K11.04716768
25LATS21.03156035
26KIT1.03052504
27IKBKE0.96562655
28STK390.95739559
29EIF2AK20.94558196
30TAF10.92882741
31BRD40.91935387
32GRK60.91736692
33MOS0.91649154
34CAMK2D0.88406352
35CAMK2B0.88051508
36ABL20.87312131
37PAK20.86790319
38CAMK2G0.77228688
39CDK70.75476667
40CDK40.75308761
41MATK0.75154154
42CSF1R0.74211204
43SIK10.73240107
44PDK20.72611288
45PTK60.70275196
46EPHA20.69793474
47MTOR0.66819145
48BTK0.66097526
49FLT30.63837150
50MAP2K70.61007576
51HCK0.61002760
52SCYL20.60972053
53JAK10.59739230
54ARAF0.59311115
55ABL10.58890387
56PAK60.58669762
57CHUK0.58575505
58RPS6KA40.56808793
59PDGFRB0.54898049
60ZAP700.53011513
61MAP3K60.51856060
62TEC0.50063461
63KDR0.49203005
64PRKCQ0.47670272
65RPS6KA60.46593011
66RPS6KC10.46421008
67RPS6KL10.46421008
68NTRK30.45505379
69PRKD20.45464700
70HIPK20.44376757
71ICK0.43767908
72SMG10.40133179
73SIK30.36346657
74MAPK40.35874039
75TESK20.34948547
76SYK0.34541032
77TNK20.34043029
78MARK20.31833351
79PRKD30.31105615
80OXSR10.29612229
81CSK0.29314081
82IRAK30.29119620
83CHEK10.28491743
84LCK0.27689521
85CDK140.27442446
86MAPK140.27262806
87LYN0.26754644
88MAP2K60.26549970
89ERN10.24298829
90RPS6KA10.23525342
91MAP2K30.23332580
92MAPKAPK20.23068664
93SIK20.23028049
94CHEK20.22110921
95JAK20.21699616
96WNK40.19961150
97MAPK10.19285045
98STK38L0.17977829
99TRIM280.17296694
100PKN20.16037572

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.18758024
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.14355385
3Bladder cancer_Homo sapiens_hsa052192.81579060
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.38486552
5Basal transcription factors_Homo sapiens_hsa030222.30491036
6Fatty acid elongation_Homo sapiens_hsa000622.22645228
7Primary immunodeficiency_Homo sapiens_hsa053402.06670510
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.03771653
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03492817
10Sulfur relay system_Homo sapiens_hsa041221.99878631
11Chronic myeloid leukemia_Homo sapiens_hsa052201.99760287
12Lysosome_Homo sapiens_hsa041421.84553133
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78604399
14Acute myeloid leukemia_Homo sapiens_hsa052211.78276144
15B cell receptor signaling pathway_Homo sapiens_hsa046621.77832806
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74396848
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69361873
18Fanconi anemia pathway_Homo sapiens_hsa034601.57994126
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54702308
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54621461
21Nicotine addiction_Homo sapiens_hsa050331.53257328
22Notch signaling pathway_Homo sapiens_hsa043301.49577912
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48229222
24p53 signaling pathway_Homo sapiens_hsa041151.47255778
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45483036
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44062217
27Hepatitis C_Homo sapiens_hsa051601.40090335
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36092394
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33712951
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.32665635
31Other glycan degradation_Homo sapiens_hsa005111.31872864
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31312824
33Base excision repair_Homo sapiens_hsa034101.23076677
34Melanoma_Homo sapiens_hsa052181.20593996
35ErbB signaling pathway_Homo sapiens_hsa040121.19118969
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.19118079
37Herpes simplex infection_Homo sapiens_hsa051681.18702742
38Apoptosis_Homo sapiens_hsa042101.16211165
39Shigellosis_Homo sapiens_hsa051311.15224472
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.11574624
41Non-small cell lung cancer_Homo sapiens_hsa052231.10991715
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.09306999
43RNA degradation_Homo sapiens_hsa030181.08269270
44Epstein-Barr virus infection_Homo sapiens_hsa051691.07854191
45Glioma_Homo sapiens_hsa052141.06937124
46Osteoclast differentiation_Homo sapiens_hsa043801.01263260
47DNA replication_Homo sapiens_hsa030301.00340722
48Measles_Homo sapiens_hsa051621.00244234
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.97128049
50Ras signaling pathway_Homo sapiens_hsa040140.96420234
51Leishmaniasis_Homo sapiens_hsa051400.96128851
52Malaria_Homo sapiens_hsa051440.95906507
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.94273014
54T cell receptor signaling pathway_Homo sapiens_hsa046600.93727102
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90959852
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88929854
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87962778
58Hepatitis B_Homo sapiens_hsa051610.86484770
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84648898
60Circadian rhythm_Homo sapiens_hsa047100.81101224
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79260381
62Inositol phosphate metabolism_Homo sapiens_hsa005620.79141431
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74417747
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73292174
65Purine metabolism_Homo sapiens_hsa002300.69834489
66Platelet activation_Homo sapiens_hsa046110.69390880
67Ribosome_Homo sapiens_hsa030100.68338499
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67816512
69Fatty acid metabolism_Homo sapiens_hsa012120.66485980
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.66405398
71MAPK signaling pathway_Homo sapiens_hsa040100.63748947
72Influenza A_Homo sapiens_hsa051640.63722052
73Small cell lung cancer_Homo sapiens_hsa052220.61325077
74Morphine addiction_Homo sapiens_hsa050320.59990749
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59049480
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58343463
77Glycerolipid metabolism_Homo sapiens_hsa005610.58100595
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53374428
79Linoleic acid metabolism_Homo sapiens_hsa005910.52883988
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.52781416
81Chemical carcinogenesis_Homo sapiens_hsa052040.52700027
82Cell cycle_Homo sapiens_hsa041100.51590896
83Cholinergic synapse_Homo sapiens_hsa047250.51388090
84Chemokine signaling pathway_Homo sapiens_hsa040620.50423177
85Prostate cancer_Homo sapiens_hsa052150.47151002
86TNF signaling pathway_Homo sapiens_hsa046680.46874785
87FoxO signaling pathway_Homo sapiens_hsa040680.46419897
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44866136
89Peroxisome_Homo sapiens_hsa041460.43291540
90VEGF signaling pathway_Homo sapiens_hsa043700.41960702
91Phototransduction_Homo sapiens_hsa047440.39791533
92Pancreatic cancer_Homo sapiens_hsa052120.39049634
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34413153
94Legionellosis_Homo sapiens_hsa051340.32146667
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.31733453
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31528222
97Caffeine metabolism_Homo sapiens_hsa002320.31213190
98Insulin resistance_Homo sapiens_hsa049310.30820006
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30787256
100HIF-1 signaling pathway_Homo sapiens_hsa040660.29566591

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