DGUOK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.53679454
2viral transcription (GO:0019083)5.82425757
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.76748230
4DNA deamination (GO:0045006)5.73468188
5translational termination (GO:0006415)5.53779828
6respiratory electron transport chain (GO:0022904)5.37350724
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.35328380
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.31687826
9ribosomal small subunit biogenesis (GO:0042274)5.31270554
10electron transport chain (GO:0022900)5.28175343
11cotranslational protein targeting to membrane (GO:0006613)5.25646697
12protein targeting to ER (GO:0045047)5.18496737
13protein neddylation (GO:0045116)5.00461485
14protein localization to endoplasmic reticulum (GO:0070972)4.95926227
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.93384242
16translational elongation (GO:0006414)4.75711064
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59442048
18viral life cycle (GO:0019058)4.41587490
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.15559125
20platelet dense granule organization (GO:0060155)4.11719072
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11250880
22cellular protein complex disassembly (GO:0043624)4.09552289
23regulation of cellular amino acid metabolic process (GO:0006521)4.08983044
24response to interferon-beta (GO:0035456)4.08963609
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.08632281
26maturation of SSU-rRNA (GO:0030490)4.06745252
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.03817853
28negative regulation of ligase activity (GO:0051352)4.03817853
29proteasome assembly (GO:0043248)3.97681295
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83850238
31cullin deneddylation (GO:0010388)3.83673940
32ATP biosynthetic process (GO:0006754)3.72823932
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71542594
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71542594
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.71472597
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71472597
37lymphoid progenitor cell differentiation (GO:0002320)3.69608176
38translational initiation (GO:0006413)3.69397073
39protein targeting to mitochondrion (GO:0006626)3.68973230
40protein-cofactor linkage (GO:0018065)3.64423246
41positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63592026
42protein deneddylation (GO:0000338)3.62997364
43hydrogen ion transmembrane transport (GO:1902600)3.62503556
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.62376722
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62376722
46rRNA modification (GO:0000154)3.62254940
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.60807068
48respiratory chain complex IV assembly (GO:0008535)3.60450216
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.59740817
50signal peptide processing (GO:0006465)3.56115745
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.54842719
52establishment of protein localization to mitochondrion (GO:0072655)3.53109338
53protein complex biogenesis (GO:0070271)3.52966005
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.52937986
55DNA damage response, detection of DNA damage (GO:0042769)3.51622236
56NADH dehydrogenase complex assembly (GO:0010257)3.51586232
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51586232
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.51586232
59positive regulation of ligase activity (GO:0051351)3.49494712
60spliceosomal snRNP assembly (GO:0000387)3.49424671
61protein localization to mitochondrion (GO:0070585)3.48176369
62protein complex disassembly (GO:0043241)3.45267324
63inner mitochondrial membrane organization (GO:0007007)3.43973617
64daunorubicin metabolic process (GO:0044597)3.43339994
65polyketide metabolic process (GO:0030638)3.43339994
66doxorubicin metabolic process (GO:0044598)3.43339994
67protein targeting to membrane (GO:0006612)3.42816446
68sequestering of actin monomers (GO:0042989)3.39991417
69translation (GO:0006412)3.33960090
70metallo-sulfur cluster assembly (GO:0031163)3.32705575
71iron-sulfur cluster assembly (GO:0016226)3.32705575
72antigen processing and presentation via MHC class Ib (GO:0002475)3.31339829
73proton transport (GO:0015992)3.28321522
74ribosomal large subunit biogenesis (GO:0042273)3.27705535
75macromolecular complex disassembly (GO:0032984)3.26256601
76mitochondrial respiratory chain complex assembly (GO:0033108)3.26065389
77negative regulation of erythrocyte differentiation (GO:0045647)3.25079114
78hydrogen transport (GO:0006818)3.21702536
79antigen processing and presentation of endogenous antigen (GO:0019883)3.21158855
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19083386
81water-soluble vitamin biosynthetic process (GO:0042364)3.17575145
82regulation of ubiquitin-protein transferase activity (GO:0051438)3.16080533
83cellular response to interferon-beta (GO:0035458)3.15582641
84regulation of mitochondrial translation (GO:0070129)3.14473783
85ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13290220
86cytochrome complex assembly (GO:0017004)3.12663787
87DNA double-strand break processing (GO:0000729)3.12475827
887-methylguanosine mRNA capping (GO:0006370)3.12290875
89positive regulation of granulocyte differentiation (GO:0030854)3.12243335
90nuclear-transcribed mRNA catabolic process (GO:0000956)3.11997743
91defense response to protozoan (GO:0042832)3.09705369
92regulation of ligase activity (GO:0051340)3.06311391
93chromatin remodeling at centromere (GO:0031055)3.05964255
94intracellular protein transmembrane import (GO:0044743)3.04890619
957-methylguanosine RNA capping (GO:0009452)3.04077742
96RNA capping (GO:0036260)3.04077742
97mannosylation (GO:0097502)3.03761830
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02894273
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01728094
100CENP-A containing nucleosome assembly (GO:0034080)3.01603654
101telomere maintenance via semi-conservative replication (GO:0032201)3.01564877
102mRNA catabolic process (GO:0006402)3.00536114
103regulation of cellular amine metabolic process (GO:0033238)3.00348209
104mitochondrial transport (GO:0006839)2.99395682
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97383089
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.96711344
107termination of RNA polymerase III transcription (GO:0006386)2.96711344
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94428043
109DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93993440
110nucleoside triphosphate biosynthetic process (GO:0009142)2.93183068
111pseudouridine synthesis (GO:0001522)2.92987181
112regulation of mitotic spindle checkpoint (GO:1903504)2.91430240
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91430240
114establishment of integrated proviral latency (GO:0075713)2.90058867
115GTP biosynthetic process (GO:0006183)2.89965822
116positive regulation of gamma-delta T cell activation (GO:0046645)2.89626016
117chaperone-mediated protein transport (GO:0072321)2.89409391
118cellular component biogenesis (GO:0044085)2.89188862
119ribonucleoprotein complex biogenesis (GO:0022613)2.88888053
120response to protozoan (GO:0001562)2.86636195
121definitive hemopoiesis (GO:0060216)2.86560546
122mast cell activation (GO:0045576)2.83661623
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83336221
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83089370
125maturation of 5.8S rRNA (GO:0000460)2.82738232
126deoxyribonucleotide catabolic process (GO:0009264)2.81368906
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76410012
128peptidyl-histidine modification (GO:0018202)2.76179910
129RNA catabolic process (GO:0006401)2.74392439
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71398149
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69525060
132GPI anchor biosynthetic process (GO:0006506)2.69358074
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.69245983
134regulation of regulatory T cell differentiation (GO:0045589)2.68845354
135deoxyribose phosphate catabolic process (GO:0046386)2.67132363
136energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66972421
137ATP synthesis coupled proton transport (GO:0015986)2.66972421
138* deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65611614
139telomere maintenance via recombination (GO:0000722)2.64711761
140oxidative phosphorylation (GO:0006119)2.64561751
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64258428
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64258428
143positive regulation of B cell differentiation (GO:0045579)2.62238797
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61376822
145signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61376822
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61376822
147establishment of viral latency (GO:0019043)2.60546413
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60440986
149isotype switching (GO:0045190)2.60440986
150somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60440986
151negative regulation of nitric oxide biosynthetic process (GO:0045019)2.58649500
152mature B cell differentiation involved in immune response (GO:0002313)2.57686552
153DNA strand elongation (GO:0022616)2.55076977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04101138
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.76065515
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.48383705
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34424334
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27165548
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.19651579
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16540209
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.15162612
9* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.07028441
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04794813
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.03977135
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01973626
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01602894
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.91699471
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.81011541
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77012271
17SCL_19346495_ChIP-Seq_HPC-7_Human2.76571005
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.62702623
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.61704589
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58523933
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53860791
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51335941
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47195646
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41508719
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.40951259
26* VDR_23849224_ChIP-Seq_CD4+_Human2.39673365
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37964693
28ERG_20887958_ChIP-Seq_HPC-7_Mouse2.35270100
29E2F7_22180533_ChIP-Seq_HELA_Human2.24988914
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20219690
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.15524390
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15446076
33FOXP3_21729870_ChIP-Seq_TREG_Human2.13532870
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12046535
35ZNF274_21170338_ChIP-Seq_K562_Hela2.10082628
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00996676
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.00501160
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99036449
39* SPI1_23547873_ChIP-Seq_NB4_Human1.98808664
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96088640
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93970536
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93524964
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.89513062
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84219180
45DCP1A_22483619_ChIP-Seq_HELA_Human1.82436200
46* ELK1_19687146_ChIP-ChIP_HELA_Human1.79177620
47XRN2_22483619_ChIP-Seq_HELA_Human1.76743527
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74412068
49VDR_22108803_ChIP-Seq_LS180_Human1.74399670
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73095322
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71110762
52* GABP_19822575_ChIP-Seq_HepG2_Human1.63636481
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60347601
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56342743
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.54929897
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53173849
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50199926
58* TTF2_22483619_ChIP-Seq_HELA_Human1.48054611
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.47359747
60CIITA_25753668_ChIP-Seq_RAJI_Human1.47260171
61EWS_26573619_Chip-Seq_HEK293_Human1.45197988
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44776175
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43232751
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.42393410
65VDR_21846776_ChIP-Seq_THP-1_Human1.39337111
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37872158
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34153982
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33540526
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.31825710
70FUS_26573619_Chip-Seq_HEK293_Human1.30662027
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28921495
72GATA1_22025678_ChIP-Seq_K562_Human1.26987726
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25881289
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25412683
75* ELK1_22589737_ChIP-Seq_MCF10A_Human1.25149793
76RUNX_20019798_ChIP-Seq_JUKART_Human1.24924953
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24859386
78MYB_26560356_Chip-Seq_TH2_Human1.24819750
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24391825
80TP53_22573176_ChIP-Seq_HFKS_Human1.22509122
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.21751593
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20006498
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16253289
84IRF1_19129219_ChIP-ChIP_H3396_Human1.15600817
85IGF1R_20145208_ChIP-Seq_DFB_Human1.14382161
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.13992838
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13348495
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13316354
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12620997
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09949213
91VDR_24763502_ChIP-Seq_THP-1_Human1.08502625
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08010452
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07323699
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07285889
95NANOG_16153702_ChIP-ChIP_HESCs_Human1.06319396
96KDM5A_27292631_Chip-Seq_BREAST_Human1.05967978
97* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05938756
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05729038
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05042648
100MYB_26560356_Chip-Seq_TH1_Human1.04595314
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04025303
102MYC_18940864_ChIP-ChIP_HL60_Human1.03641041
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03249854
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03041640
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02976878
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02542813
107MAF_26560356_Chip-Seq_TH1_Human1.01795632
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99268867
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98739738
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97280382
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96838194
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96090974
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96075637
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96068193
115TAF15_26573619_Chip-Seq_HEK293_Human0.95596901
116P300_19829295_ChIP-Seq_ESCs_Human0.94148942
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93362727
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93355797
119HTT_18923047_ChIP-ChIP_STHdh_Human0.93310721
120CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92882273
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92596226
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90959323
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90593012
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.90593012
125MAF_26560356_Chip-Seq_TH2_Human0.90140862
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89450496
127* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89410023
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89099622
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87678403
130* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87386829
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86995850
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84904467
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84732431
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83647906
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82397003
136NANOG_19829295_ChIP-Seq_ESCs_Human0.80252318
137SOX2_19829295_ChIP-Seq_ESCs_Human0.80252318
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76489361
139AR_20517297_ChIP-Seq_VCAP_Human0.76410708
140ERG_20517297_ChIP-Seq_VCAP_Human0.76121297
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74149330
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73729101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63350339
2MP0002396_abnormal_hematopoietic_system3.39250403
3MP0005671_abnormal_response_to3.19098156
4MP0009379_abnormal_foot_pigmentation3.17328373
5MP0000685_abnormal_immune_system3.07705257
6MP0006292_abnormal_olfactory_placode2.90644262
7MP0003724_increased_susceptibility_to2.84773599
8MP0009785_altered_susceptibility_to2.74732899
9MP0003763_abnormal_thymus_physiology2.72723320
10MP0002102_abnormal_ear_morphology2.66096040
11MP0005075_abnormal_melanosome_morpholog2.53791553
12MP0002148_abnormal_hypersensitivity_rea2.43512261
13MP0005174_abnormal_tail_pigmentation2.39060693
14MP0003718_maternal_effect2.37872472
15MP0008877_abnormal_DNA_methylation2.37440271
16MP0005025_abnormal_response_to2.24628717
17MP0001800_abnormal_humoral_immune2.20044224
18MP0005000_abnormal_immune_tolerance2.17358221
19MP0004147_increased_porphyrin_level2.16503105
20MP0001986_abnormal_taste_sensitivity2.13963810
21MP0002420_abnormal_adaptive_immunity2.12653644
22MP0002723_abnormal_immune_serum2.10472796
23MP0001819_abnormal_immune_cell2.08054763
24MP0002166_altered_tumor_susceptibility2.05886753
25MP0000465_gastrointestinal_hemorrhage2.05487304
26MP0002452_abnormal_antigen_presenting2.03366732
27MP0002398_abnormal_bone_marrow2.02859570
28MP0003880_abnormal_central_pattern1.98564245
29MP0000372_irregular_coat_pigmentation1.97083697
30MP0001790_abnormal_immune_system1.92129757
31MP0005387_immune_system_phenotype1.92129757
32MP0002095_abnormal_skin_pigmentation1.90953181
33MP0001984_abnormal_olfaction1.88608836
34MP0002419_abnormal_innate_immunity1.84127042
35MP0000716_abnormal_immune_system1.82056387
36MP0005464_abnormal_platelet_physiology1.81319637
37MP0001853_heart_inflammation1.80865122
38MP0008058_abnormal_DNA_repair1.78820409
39MP0003866_abnormal_defecation1.78603844
40MP0002837_dystrophic_cardiac_calcinosis1.77827613
41MP0001873_stomach_inflammation1.77753410
42MP0000689_abnormal_spleen_morphology1.75953654
43MP0008789_abnormal_olfactory_epithelium1.75851890
44MP0003436_decreased_susceptibility_to1.74380926
45MP0009333_abnormal_splenocyte_physiolog1.68431500
46MP0002132_abnormal_respiratory_system1.67163847
47MP0001188_hyperpigmentation1.65567041
48MP0002736_abnormal_nociception_after1.64534405
49MP0002722_abnormal_immune_system1.64216201
50MP0002429_abnormal_blood_cell1.64117228
51MP0003011_delayed_dark_adaptation1.61910808
52MP0002638_abnormal_pupillary_reflex1.59138195
53MP0008007_abnormal_cellular_replicative1.57924760
54MP0001529_abnormal_vocalization1.53091174
55MP0005409_darkened_coat_color1.52869766
56MP0002163_abnormal_gland_morphology1.52776913
57MP0000015_abnormal_ear_pigmentation1.51647082
58MP0006276_abnormal_autonomic_nervous1.51452703
59MP0010155_abnormal_intestine_physiology1.50254199
60MP0000490_abnormal_crypts_of1.47167996
61MP0005551_abnormal_eye_electrophysiolog1.46624050
62MP0008995_early_reproductive_senescence1.46518912
63MP0001968_abnormal_touch/_nociception1.45476858
64MP0004808_abnormal_hematopoietic_stem1.45045699
65MP0003122_maternal_imprinting1.44518322
66MP0002006_tumorigenesis1.43375841
67MP0003195_calcinosis1.42365531
68MP0005394_taste/olfaction_phenotype1.42360155
69MP0005499_abnormal_olfactory_system1.42360155
70MP0005253_abnormal_eye_physiology1.42249296
71MP0003186_abnormal_redox_activity1.41554473
72MP0006036_abnormal_mitochondrial_physio1.41402798
73MP0003121_genomic_imprinting1.40265193
74MP0008875_abnormal_xenobiotic_pharmacok1.39192941
75MP0002822_catalepsy1.36782455
76MP0003693_abnormal_embryo_hatching1.36441685
77MP0003111_abnormal_nucleus_morphology1.35951141
78MP0001293_anophthalmia1.35927374
79MP0002405_respiratory_system_inflammati1.35755808
80MP0001545_abnormal_hematopoietic_system1.35509870
81MP0005397_hematopoietic_system_phenotyp1.35509870
82MP0008932_abnormal_embryonic_tissue1.33827105
83MP0005646_abnormal_pituitary_gland1.32433377
84MP0002653_abnormal_ependyma_morphology1.31436196
85MP0002933_joint_inflammation1.27461709
86MP0004133_heterotaxia1.27043591
87MP0000631_abnormal_neuroendocrine_gland1.26926629
88MP0002751_abnormal_autonomic_nervous1.25697264
89MP0000703_abnormal_thymus_morphology1.25198006
90MP0008872_abnormal_physiological_respon1.21603128
91MP0005645_abnormal_hypothalamus_physiol1.20740674
92MP0009697_abnormal_copulation1.19680767
93MP0001845_abnormal_inflammatory_respons1.18249662
94MP0009046_muscle_twitch1.16760891
95MP0003315_abnormal_perineum_morphology1.16549191
96MP0010094_abnormal_chromosome_stability1.15179120
97MP0001905_abnormal_dopamine_level1.14613946
98MP0002210_abnormal_sex_determination1.14452261
99MP0008469_abnormal_protein_level1.12211068
100MP0003786_premature_aging1.10381361
101MP0000681_abnormal_thyroid_gland1.09518148
102MP0003567_abnormal_fetal_cardiomyocyte1.08951730
103MP0004381_abnormal_hair_follicle1.08066997
104MP0000678_abnormal_parathyroid_gland1.06212014
105MP0003787_abnormal_imprinting1.05568686
106MP0010386_abnormal_urinary_bladder1.05503876
107MP0002090_abnormal_vision1.05487797
108MP0006082_CNS_inflammation1.03400533
109MP0001929_abnormal_gametogenesis1.02098105
110MP0000653_abnormal_sex_gland0.98182754
111MP0003077_abnormal_cell_cycle0.96789530
112MP0002277_abnormal_respiratory_mucosa0.96246220
113MP0001145_abnormal_male_reproductive0.93854524
114MP0002019_abnormal_tumor_incidence0.93378214
115MP0001485_abnormal_pinna_reflex0.93014003
116MP0009745_abnormal_behavioral_response0.91892997
117MP0002938_white_spotting0.91481950
118MP0002272_abnormal_nervous_system0.90485222
119MP0010030_abnormal_orbit_morphology0.89708374
120MP0005670_abnormal_white_adipose0.88444608
121MP0002160_abnormal_reproductive_system0.86896073
122MP0000516_abnormal_urinary_system0.86146844
123MP0005367_renal/urinary_system_phenotyp0.86146844
124MP0006035_abnormal_mitochondrial_morpho0.86067977
125MP0003943_abnormal_hepatobiliary_system0.85775268
126MP0005410_abnormal_fertilization0.85555868
127MP0003698_abnormal_male_reproductive0.85392732
128MP0000358_abnormal_cell_content/0.85256071
129MP0001533_abnormal_skeleton_physiology0.85117399
130MP0000647_abnormal_sebaceous_gland0.84695560
131MP0006072_abnormal_retinal_apoptosis0.84187601
132MP0003136_yellow_coat_color0.83071452
133MP0005636_abnormal_mineral_homeostasis0.82185456
134MP0002234_abnormal_pharynx_morphology0.79711054
135MP0002233_abnormal_nose_morphology0.79691664
136MP0005389_reproductive_system_phenotype0.78181942
137MP0003938_abnormal_ear_development0.77525983
138MP0003656_abnormal_erythrocyte_physiolo0.77150196
139MP0003937_abnormal_limbs/digits/tail_de0.75949471
140MP0002557_abnormal_social/conspecific_i0.74525032
141MP0004957_abnormal_blastocyst_morpholog0.74516589
142MP0001919_abnormal_reproductive_system0.74154570
143MP0003119_abnormal_digestive_system0.73396611
144MP0001851_eye_inflammation0.73298871
145MP0005332_abnormal_amino_acid0.72814265
146MP0000313_abnormal_cell_death0.72220780
147MP0005084_abnormal_gallbladder_morpholo0.71592939
148MP0003183_abnormal_peptide_metabolism0.71013049
149MP0002752_abnormal_somatic_nervous0.70961257
150MP0000343_altered_response_to0.70841461
151MP0003806_abnormal_nucleotide_metabolis0.70790589
152MP0003137_abnormal_impulse_conducting0.70381141
153MP0006054_spinal_hemorrhage0.69697369
154MP0002735_abnormal_chemical_nociception0.69313580
155MP0001324_abnormal_eye_pigmentation0.68455653
156MP0000049_abnormal_middle_ear0.68265602
157MP0009764_decreased_sensitivity_to0.68206864
158MP0005451_abnormal_body_composition0.68038292
159MP0001119_abnormal_female_reproductive0.67721322
160MP0001186_pigmentation_phenotype0.67645358
161MP0002909_abnormal_adrenal_gland0.67330601
162MP0001764_abnormal_homeostasis0.66893667
163MP0005391_vision/eye_phenotype0.66591474
164MP0002693_abnormal_pancreas_physiology0.64871898
165MP0004510_myositis0.63748413
166MP0002075_abnormal_coat/hair_pigmentati0.63066670
167MP0002009_preneoplasia0.63026659
168MP0004142_abnormal_muscle_tone0.62412146
169MP0004947_skin_inflammation0.61610729
170MP0005379_endocrine/exocrine_gland_phen0.60106294

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.25219833
2Abnormal number of erythroid precursors (HP:0012131)5.14126715
3Aplastic anemia (HP:0001915)4.45161843
4Type I transferrin isoform profile (HP:0003642)4.24407938
5IgM deficiency (HP:0002850)3.80904607
6Reticulocytopenia (HP:0001896)3.76922653
7Cerebral edema (HP:0002181)3.72324536
8* Hepatocellular necrosis (HP:0001404)3.70074927
9Elevated erythrocyte sedimentation rate (HP:0003565)3.55590608
10* Hepatic necrosis (HP:0002605)3.47958569
11Mitochondrial inheritance (HP:0001427)3.47869608
12Chronic otitis media (HP:0000389)3.43654157
13Thrombocytosis (HP:0001894)3.41424996
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.36730535
15Abnormal protein N-linked glycosylation (HP:0012347)3.36730535
16Abnormal protein glycosylation (HP:0012346)3.36730535
17Abnormal glycosylation (HP:0012345)3.36730535
18Acute necrotizing encephalopathy (HP:0006965)3.36139216
19Reduced antithrombin III activity (HP:0001976)3.32857493
20Abnormal mitochondria in muscle tissue (HP:0008316)3.28415262
21* Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11541235
22* Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11541235
23Increased intramyocellular lipid droplets (HP:0012240)3.03521998
24Increased CSF lactate (HP:0002490)2.94854326
25Macrocytic anemia (HP:0001972)2.93396948
26Petechiae (HP:0000967)2.89138011
27Increased hepatocellular lipid droplets (HP:0006565)2.86652477
28Optic disc pallor (HP:0000543)2.84961811
293-Methylglutaconic aciduria (HP:0003535)2.84206352
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.83245617
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82975129
32Pallor (HP:0000980)2.81517992
33Increased muscle lipid content (HP:0009058)2.80849419
34Recurrent abscess formation (HP:0002722)2.80323990
35Methylmalonic acidemia (HP:0002912)2.79214532
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77330251
37Abnormality of B cell number (HP:0010975)2.74603216
38B lymphocytopenia (HP:0010976)2.74603216
39Panhypogammaglobulinemia (HP:0003139)2.73040536
40Abnormality of renal resorption (HP:0011038)2.69487308
41Renal Fanconi syndrome (HP:0001994)2.68817547
42Lipid accumulation in hepatocytes (HP:0006561)2.68197026
43Myositis (HP:0100614)2.64506910
44Molar tooth sign on MRI (HP:0002419)2.63432294
45Abnormality of midbrain morphology (HP:0002418)2.63432294
46Recurrent bronchitis (HP:0002837)2.61984089
47Microvesicular hepatic steatosis (HP:0001414)2.61539336
48Abnormality of the columella (HP:0009929)2.58701264
49Type 2 muscle fiber atrophy (HP:0003554)2.58326490
50Acute encephalopathy (HP:0006846)2.57619510
51Medial flaring of the eyebrow (HP:0010747)2.57220807
52Increased serum lactate (HP:0002151)2.55029583
53Prolonged bleeding time (HP:0003010)2.50316394
54Exertional dyspnea (HP:0002875)2.50203536
55Congenital, generalized hypertrichosis (HP:0004540)2.48318283
56Recurrent bacterial skin infections (HP:0005406)2.46053762
57Lethargy (HP:0001254)2.45860996
58Glycosuria (HP:0003076)2.44769601
59Abnormality of urine glucose concentration (HP:0011016)2.44769601
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40185337
61Abnormality of the labia minora (HP:0012880)2.39357648
62Progressive macrocephaly (HP:0004481)2.39035381
63IgG deficiency (HP:0004315)2.37980616
64Degeneration of anterior horn cells (HP:0002398)2.37385227
65Abnormality of the anterior horn cell (HP:0006802)2.37385227
66* Lactic acidosis (HP:0003128)2.36830074
67Hyperglycinemia (HP:0002154)2.34208716
68Muscle fiber atrophy (HP:0100295)2.34134842
69Severe visual impairment (HP:0001141)2.34003446
70Colon cancer (HP:0003003)2.33915956
71Patchy hypopigmentation of hair (HP:0011365)2.30835862
72Pancytopenia (HP:0001876)2.29521726
73Hypoplasia of the thymus (HP:0000778)2.28077235
74Neutropenia (HP:0001875)2.25506641
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23813262
76Exercise intolerance (HP:0003546)2.23588984
77Eczematoid dermatitis (HP:0000976)2.22038040
78Microcytic anemia (HP:0001935)2.21549745
79Nephronophthisis (HP:0000090)2.20804565
80Pancreatic cysts (HP:0001737)2.20441514
81Abnormality of T cell physiology (HP:0011840)2.19484732
82Lymphoma (HP:0002665)2.15764153
83Asplenia (HP:0001746)2.14696408
84Hyperphosphaturia (HP:0003109)2.13648337
85CNS demyelination (HP:0007305)2.12833100
86Oral leukoplakia (HP:0002745)2.12656362
87Progressive neurologic deterioration (HP:0002344)2.12539573
88Congenital primary aphakia (HP:0007707)2.10921571
89Broad face (HP:0000283)2.10674105
90True hermaphroditism (HP:0010459)2.10594341
91Pancreatic fibrosis (HP:0100732)2.09382812
92Hypoproteinemia (HP:0003075)2.08334311
93Gait imbalance (HP:0002141)2.07890615
94Gastrointestinal stroma tumor (HP:0100723)2.06153263
95Agammaglobulinemia (HP:0004432)2.03802225
96Autoimmune hemolytic anemia (HP:0001890)2.02716734
97Sclerocornea (HP:0000647)2.00832545
98Nephrogenic diabetes insipidus (HP:0009806)2.00708518
99Epistaxis (HP:0000421)1.99834379
100X-linked dominant inheritance (HP:0001423)1.96735706
101Aplasia/hypoplasia of the uterus (HP:0008684)1.96454962
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.95689331
103Emotional lability (HP:0000712)1.94905173
104Respiratory failure (HP:0002878)1.94858135
105Abnormal rod and cone electroretinograms (HP:0008323)1.94065803
106White forelock (HP:0002211)1.92987724
107Septo-optic dysplasia (HP:0100842)1.92093235
108Poor head control (HP:0002421)1.91192441
109Abnormality of T cells (HP:0002843)1.90734749
110Recurrent skin infections (HP:0001581)1.89859819
111Lymphopenia (HP:0001888)1.89605229
112Cerebral hypomyelination (HP:0006808)1.89380131
113Meningitis (HP:0001287)1.88675238
114Erythema (HP:0010783)1.86697637
115Abnormality of macrophages (HP:0004311)1.85449633
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.85423739
117Gonadotropin excess (HP:0000837)1.85000961
118Respiratory difficulties (HP:0002880)1.84564284
119Recurrent viral infections (HP:0004429)1.84045841
120Premature graying of hair (HP:0002216)1.78721732
121Purpura (HP:0000979)1.78607115
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.77457223
123Severe combined immunodeficiency (HP:0004430)1.76708578
124Meckel diverticulum (HP:0002245)1.76482096
125Abnormality of eosinophils (HP:0001879)1.76141999
126Methylmalonic aciduria (HP:0012120)1.75924784
127Leukodystrophy (HP:0002415)1.75670880
128Dicarboxylic aciduria (HP:0003215)1.75532352
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75532352
130Abnormality of serum amino acid levels (HP:0003112)1.73289985
131Genital tract atresia (HP:0001827)1.73146745
132Vaginal atresia (HP:0000148)1.71877107
133Abnormality of the ileum (HP:0001549)1.69280699
134Poor suck (HP:0002033)1.69145712
135Hypoplasia of the pons (HP:0012110)1.67977214
136Abnormality of the pons (HP:0007361)1.67953483
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.66742547
138Abnormality of the renal medulla (HP:0100957)1.65214397
139Abnormality of methionine metabolism (HP:0010901)1.64652800
140Congenital stationary night blindness (HP:0007642)1.63540800
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63413862
142Abnormality of vitamin B metabolism (HP:0004340)1.62728419
143Blindness (HP:0000618)1.61709954
144Hypoglycemic coma (HP:0001325)1.61577388
145Delayed CNS myelination (HP:0002188)1.59662971
146Median cleft lip (HP:0000161)1.57922379
147Male pseudohermaphroditism (HP:0000037)1.57626325
148Hyperglycinuria (HP:0003108)1.57200442
149Renal cortical cysts (HP:0000803)1.56963653
150Increased serum pyruvate (HP:0003542)1.56920679
151Pendular nystagmus (HP:0012043)1.54466772
152Short tibia (HP:0005736)1.53873119
153Myokymia (HP:0002411)1.53309601
154Anencephaly (HP:0002323)1.52703517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48483574
2NME23.58159770
3CDK193.34860888
4KIT3.18587142
5TNIK2.98928309
6STK162.92838996
7MAP4K12.83758806
8FLT32.78187334
9MAP3K122.71872991
10ZAK2.59555164
11MAP4K22.40744505
12TXK2.39296541
13NME12.34812692
14WNK32.33738730
15MUSK2.31933451
16TEC2.22251120
17TESK22.12994652
18NUAK12.12976227
19BTK2.06061072
20TRIM281.99668994
21TGFBR11.92206428
22CDC71.91973889
23VRK11.88210120
24IRAK41.79384224
25WEE11.78434429
26PBK1.76318164
27TGFBR21.72424523
28NEK11.68007160
29BCKDK1.66373559
30EIF2AK31.65603443
31KDR1.60301478
32PLK31.56441068
33MYLK1.53756343
34ZAP701.51012073
35JAK31.48421990
36CSF1R1.47640843
37BCR1.46025130
38MAPKAPK51.43261045
39SYK1.40669384
40CDK81.34969004
41IKBKE1.31869188
42PIM21.31308894
43BUB11.27736694
44TSSK61.27341940
45CSNK1G11.23579616
46CSNK1G21.19852719
47TAF11.19309427
48GRK11.18840525
49TBK11.18384700
50IKBKB1.17278436
51ADRBK21.15598235
52TIE11.14892350
53BRSK21.13838203
54MAP2K71.12062665
55TTK1.10120096
56PASK1.09261196
57MAP3K41.08026126
58RPS6KB21.05832399
59BMPR1B1.05547849
60TAOK31.05220789
61EIF2AK11.04996061
62BLK1.03322910
63NLK1.02458889
64MAP2K31.01799295
65ARAF1.01088965
66MKNK11.00112251
67INSRR0.99512783
68CSNK1A1L0.96896118
69LCK0.95948426
70ILK0.95629073
71PLK10.95611265
72LYN0.93690250
73ACVR1B0.90995624
74TYK20.88087494
75CAMK10.87704221
76DYRK30.86351596
77MAPK130.86102318
78IRAK30.85832695
79LIMK10.84477067
80CASK0.84307432
81CAMKK20.83793769
82DAPK10.83677735
83FRK0.83628191
84MAPK150.82522988
85PLK20.81504939
86MKNK20.81101973
87MAP2K60.79533641
88SRPK10.77238311
89LRRK20.75772459
90MINK10.73099987
91WNK40.72357859
92MOS0.70244407
93TLK10.70097889
94AURKB0.69893750
95ERBB30.67928651
96PDK20.67546575
97STK100.67272236
98SIK30.67122932
99PRKCG0.66198778
100GRK70.66175040
101CSNK2A20.66174745
102PRKG20.65611877
103MAP3K130.65549392
104MATK0.64599077
105EIF2AK20.64536217
106BMPR20.62884619
107PLK40.60251559
108MAP3K60.59883255
109HIPK20.57567596
110ITK0.56320096
111TESK10.54532096
112AURKA0.53741631
113ABL20.53021143
114MST40.52789511
115YES10.52452584
116CDK70.51831045
117MAPK40.51668162
118CHEK20.51375097
119PRKCE0.51159092
120MAPKAPK30.49252547
121CLK10.49116351
122MAP3K70.48822033
123TNK20.48202005
124MAP3K110.48164448
125CCNB10.48134627
126PHKG10.47616518
127PHKG20.47616518
128RPS6KA50.44371542
129MAP3K140.44075696
130ADRBK10.43273456
131ATM0.42264059
132RPS6KA60.41214966
133CSNK1A10.40817756
134FES0.40600425
135DAPK30.40265065
136PRKCI0.39733577
137PINK10.37883110
138DYRK20.37120337
139ATR0.36674434
140IRAK10.36068565
141CSNK1G30.36023434
142BRAF0.35753147
143PAK30.35499757
144CSNK1E0.35451759
145MAP2K20.34501924
146NEK60.33731596
147GRK50.32836785
148STK390.32519760
149PRKCQ0.32193261
150CAMK2A0.31938155
151CSNK2A10.31760725
152BRSK10.31691802
153PRKCD0.31396612
154OXSR10.30699418
155PIM10.30243313

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.30376507
2Protein export_Homo sapiens_hsa030603.63696585
3DNA replication_Homo sapiens_hsa030303.17551309
4Proteasome_Homo sapiens_hsa030503.14029540
5RNA polymerase_Homo sapiens_hsa030202.89263796
6Mismatch repair_Homo sapiens_hsa034302.71832614
7Base excision repair_Homo sapiens_hsa034102.39625321
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39053341
9Primary immunodeficiency_Homo sapiens_hsa053402.36945402
10Homologous recombination_Homo sapiens_hsa034402.30182308
11Pyrimidine metabolism_Homo sapiens_hsa002402.27540137
12Oxidative phosphorylation_Homo sapiens_hsa001902.25391549
13Parkinsons disease_Homo sapiens_hsa050122.11642032
14Non-homologous end-joining_Homo sapiens_hsa034502.03550889
15Nucleotide excision repair_Homo sapiens_hsa034202.02082082
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97314757
17Spliceosome_Homo sapiens_hsa030401.78182344
18Cardiac muscle contraction_Homo sapiens_hsa042601.70178778
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66390347
20Folate biosynthesis_Homo sapiens_hsa007901.52503007
21Basal transcription factors_Homo sapiens_hsa030221.50090310
22RNA degradation_Homo sapiens_hsa030181.49856319
23Fatty acid elongation_Homo sapiens_hsa000621.45337522
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40865654
25Propanoate metabolism_Homo sapiens_hsa006401.40798364
26Alzheimers disease_Homo sapiens_hsa050101.34547268
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32854924
28Huntingtons disease_Homo sapiens_hsa050161.28497672
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27653347
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25935779
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24995455
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23529562
33Hematopoietic cell lineage_Homo sapiens_hsa046401.20263325
34Butanoate metabolism_Homo sapiens_hsa006501.17199046
35* Purine metabolism_Homo sapiens_hsa002301.16923717
36Allograft rejection_Homo sapiens_hsa053301.11149119
37N-Glycan biosynthesis_Homo sapiens_hsa005101.10973203
38Collecting duct acid secretion_Homo sapiens_hsa049661.09827752
39Phototransduction_Homo sapiens_hsa047441.09493515
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09301392
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.08891866
42Selenocompound metabolism_Homo sapiens_hsa004501.05091316
43Herpes simplex infection_Homo sapiens_hsa051681.01664617
44Measles_Homo sapiens_hsa051621.01542853
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99594372
46Leishmaniasis_Homo sapiens_hsa051400.99412854
47Sulfur relay system_Homo sapiens_hsa041220.97346264
48Antigen processing and presentation_Homo sapiens_hsa046120.97132137
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96900466
50Caffeine metabolism_Homo sapiens_hsa002320.96646227
51Other glycan degradation_Homo sapiens_hsa005110.95454629
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.94887123
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94814526
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94438427
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94123958
56Pyruvate metabolism_Homo sapiens_hsa006200.91172026
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88776901
58Fanconi anemia pathway_Homo sapiens_hsa034600.85188499
59Arachidonic acid metabolism_Homo sapiens_hsa005900.84176467
60Steroid biosynthesis_Homo sapiens_hsa001000.83513629
61B cell receptor signaling pathway_Homo sapiens_hsa046620.81151869
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.80630232
63Pentose phosphate pathway_Homo sapiens_hsa000300.79726163
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.77791344
65Asthma_Homo sapiens_hsa053100.77260195
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75214288
67Epstein-Barr virus infection_Homo sapiens_hsa051690.71483074
68Shigellosis_Homo sapiens_hsa051310.69967630
69Pertussis_Homo sapiens_hsa051330.66364521
70Malaria_Homo sapiens_hsa051440.66145051
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65562295
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64432277
73RNA transport_Homo sapiens_hsa030130.63434231
74Galactose metabolism_Homo sapiens_hsa000520.62481860
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.62356852
76Autoimmune thyroid disease_Homo sapiens_hsa053200.62233950
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.61013766
78Cell cycle_Homo sapiens_hsa041100.60581126
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60012551
80Nitrogen metabolism_Homo sapiens_hsa009100.59518658
81Sphingolipid metabolism_Homo sapiens_hsa006000.58955879
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58871642
83Glutathione metabolism_Homo sapiens_hsa004800.57902566
84* Metabolic pathways_Homo sapiens_hsa011000.57042174
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55245381
86Chemical carcinogenesis_Homo sapiens_hsa052040.54401457
87Sulfur metabolism_Homo sapiens_hsa009200.54153571
88Peroxisome_Homo sapiens_hsa041460.53955080
89T cell receptor signaling pathway_Homo sapiens_hsa046600.53702247
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53471860
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52788381
92Tryptophan metabolism_Homo sapiens_hsa003800.52244073
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.51406504
94Legionellosis_Homo sapiens_hsa051340.49903725
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47843095
96Rheumatoid arthritis_Homo sapiens_hsa053230.46815247
97Regulation of autophagy_Homo sapiens_hsa041400.46031308
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45615404
99Linoleic acid metabolism_Homo sapiens_hsa005910.44569461
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44067173
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43960559
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42673963
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42131424
104p53 signaling pathway_Homo sapiens_hsa041150.42089486
105Carbon metabolism_Homo sapiens_hsa012000.41791128
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41738290
107Acute myeloid leukemia_Homo sapiens_hsa052210.41732402
108One carbon pool by folate_Homo sapiens_hsa006700.40187661
109Oocyte meiosis_Homo sapiens_hsa041140.40174733
110mRNA surveillance pathway_Homo sapiens_hsa030150.39970943
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39116912
112Vibrio cholerae infection_Homo sapiens_hsa051100.38670462
113Nicotine addiction_Homo sapiens_hsa050330.37983307
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37435723
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.37207766
116beta-Alanine metabolism_Homo sapiens_hsa004100.35871309
117Osteoclast differentiation_Homo sapiens_hsa043800.34938549
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34691228
119Systemic lupus erythematosus_Homo sapiens_hsa053220.32565562
120Influenza A_Homo sapiens_hsa051640.32156635
121Retinol metabolism_Homo sapiens_hsa008300.31884411
122Olfactory transduction_Homo sapiens_hsa047400.31642758
123Type I diabetes mellitus_Homo sapiens_hsa049400.31210548
124Platelet activation_Homo sapiens_hsa046110.29538171
125Biosynthesis of amino acids_Homo sapiens_hsa012300.28529160
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28020280
127Tyrosine metabolism_Homo sapiens_hsa003500.26812251
128Hepatitis B_Homo sapiens_hsa051610.25950926
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25605524
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25006512
131Vitamin B6 metabolism_Homo sapiens_hsa007500.24984007
132Ether lipid metabolism_Homo sapiens_hsa005650.24775863
133Fatty acid metabolism_Homo sapiens_hsa012120.23926830
134Thyroid cancer_Homo sapiens_hsa052160.23898754
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.22859313
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22519640
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22411550
138African trypanosomiasis_Homo sapiens_hsa051430.20973640
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20889131
140Fatty acid degradation_Homo sapiens_hsa000710.20803780
141ABC transporters_Homo sapiens_hsa020100.20428852
142Taste transduction_Homo sapiens_hsa047420.19480055

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