DHCR24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)8.66255388
2glucocorticoid metabolic process (GO:0008211)8.40967498
3cellular response to follicle-stimulating hormone stimulus (GO:0071372)8.40770266
4L-phenylalanine catabolic process (GO:0006559)7.43187585
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.43187585
6L-phenylalanine metabolic process (GO:0006558)7.03576485
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.03576485
8low-density lipoprotein particle clearance (GO:0034383)6.90462420
9response to follicle-stimulating hormone (GO:0032354)6.73360632
10aromatic amino acid family catabolic process (GO:0009074)6.35113609
11estrogen biosynthetic process (GO:0006703)5.95632548
12cellular response to gonadotropin stimulus (GO:0071371)5.77280104
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.76464830
14C21-steroid hormone biosynthetic process (GO:0006700)5.70716731
15glyoxylate metabolic process (GO:0046487)5.70399968
16alpha-linolenic acid metabolic process (GO:0036109)5.67521470
17bile acid biosynthetic process (GO:0006699)5.56804425
18tryptophan catabolic process (GO:0006569)5.40634096
19indole-containing compound catabolic process (GO:0042436)5.40634096
20indolalkylamine catabolic process (GO:0046218)5.40634096
21kynurenine metabolic process (GO:0070189)5.39702538
22negative regulation of fibrinolysis (GO:0051918)5.20481387
23cysteine metabolic process (GO:0006534)5.18727956
24urea metabolic process (GO:0019627)5.13271639
25urea cycle (GO:0000050)5.13271639
26progesterone metabolic process (GO:0042448)5.12592204
27high-density lipoprotein particle remodeling (GO:0034375)5.08254255
28tryptophan metabolic process (GO:0006568)5.06446982
29sulfur amino acid catabolic process (GO:0000098)5.02626119
30peptidyl-glutamic acid carboxylation (GO:0017187)4.99128882
31protein carboxylation (GO:0018214)4.99128882
32regulation of fibrinolysis (GO:0051917)4.93348889
33fatty acid elongation (GO:0030497)4.92028114
34cellular response to antibiotic (GO:0071236)4.84963296
35regulation of transforming growth factor beta2 production (GO:0032909)4.80348449
36bile acid metabolic process (GO:0008206)4.78768089
37regulation of protein activation cascade (GO:2000257)4.75451298
38complement activation, alternative pathway (GO:0006957)4.75052047
39nitrogen cycle metabolic process (GO:0071941)4.74346720
40tyrosine metabolic process (GO:0006570)4.64512588
41adhesion of symbiont to host (GO:0044406)4.62388410
42aromatic amino acid family metabolic process (GO:0009072)4.59812855
43serine family amino acid catabolic process (GO:0009071)4.56345178
44androgen metabolic process (GO:0008209)4.54758454
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52099125
46regulation of cholesterol biosynthetic process (GO:0045540)4.47746976
47positive regulation of nitric-oxide synthase activity (GO:0051000)4.46926161
48regulation of cholesterol esterification (GO:0010872)4.44472327
49positive regulation of hormone biosynthetic process (GO:0046886)4.41507272
50reverse cholesterol transport (GO:0043691)4.41399020
51regulation of complement activation (GO:0030449)4.40385030
52negative regulation of cholesterol transport (GO:0032375)4.40048034
53negative regulation of sterol transport (GO:0032372)4.40048034
54desmosome organization (GO:0002934)4.38786820
55regulation of triglyceride catabolic process (GO:0010896)4.38313905
56homocysteine metabolic process (GO:0050667)4.36384695
57coenzyme catabolic process (GO:0009109)4.35547362
58cellular ketone body metabolic process (GO:0046950)4.35385333
59plasma lipoprotein particle clearance (GO:0034381)4.35143621
60protein-lipid complex remodeling (GO:0034368)4.33091377
61macromolecular complex remodeling (GO:0034367)4.33091377
62plasma lipoprotein particle remodeling (GO:0034369)4.33091377
63response to gonadotropin (GO:0034698)4.32096763
64alpha-amino acid catabolic process (GO:1901606)4.25866514
65acetyl-CoA metabolic process (GO:0006084)4.22177602
66acylglycerol homeostasis (GO:0055090)4.18707437
67triglyceride homeostasis (GO:0070328)4.18707437
68lysine catabolic process (GO:0006554)4.16739064
69lysine metabolic process (GO:0006553)4.16739064
70hormone biosynthetic process (GO:0042446)4.16014208
71phospholipid efflux (GO:0033700)4.15959662
72glutamate metabolic process (GO:0006536)4.15259805
73C21-steroid hormone metabolic process (GO:0008207)4.14723496
74serine family amino acid biosynthetic process (GO:0009070)4.12693743
75ethanol oxidation (GO:0006069)4.11467123
76cholesterol efflux (GO:0033344)4.11248004
77amino-acid betaine metabolic process (GO:0006577)4.11027713
78bile acid and bile salt transport (GO:0015721)4.09181401
79very long-chain fatty acid metabolic process (GO:0000038)4.07509287
80serine family amino acid metabolic process (GO:0009069)4.06991680
81positive regulation of male gonad development (GO:2000020)4.06508469
82positive regulation of triglyceride biosynthetic process (GO:0010867)4.05689934
83glycine metabolic process (GO:0006544)3.99782102
84cellular glucuronidation (GO:0052695)3.98127327
85cellular amino acid catabolic process (GO:0009063)3.96840523
86regulation of cholesterol homeostasis (GO:2000188)3.95419617
87cellular modified amino acid catabolic process (GO:0042219)3.95380233
88fibrinolysis (GO:0042730)3.92661138
89drug catabolic process (GO:0042737)3.91958327
90regulation of cholesterol storage (GO:0010885)3.90237675
91heme transport (GO:0015886)3.89376466
92fatty-acyl-CoA biosynthetic process (GO:0046949)3.86521383
93indolalkylamine metabolic process (GO:0006586)3.85810543
94plasma lipoprotein particle assembly (GO:0034377)3.85801052
95very-low-density lipoprotein particle assembly (GO:0034379)3.84447071
96* cholesterol biosynthetic process (GO:0006695)3.82947458
97imidazole-containing compound metabolic process (GO:0052803)3.82393561
98benzene-containing compound metabolic process (GO:0042537)3.80701840
99ketone body metabolic process (GO:1902224)3.79144040
100aldehyde catabolic process (GO:0046185)3.78014150
101dicarboxylic acid biosynthetic process (GO:0043650)3.76511584
102amine catabolic process (GO:0009310)3.76159197
103cellular biogenic amine catabolic process (GO:0042402)3.76159197
104long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.73091504
105cholesterol homeostasis (GO:0042632)3.72520960
106positive regulation of hormone metabolic process (GO:0032352)3.72097795
107short-chain fatty acid metabolic process (GO:0046459)3.71337648
108cofactor catabolic process (GO:0051187)3.71091189
109sterol homeostasis (GO:0055092)3.67214969
110arginine metabolic process (GO:0006525)3.65202183
111positive regulation of triglyceride lipase activity (GO:0061365)3.62526060
112positive regulation of lipoprotein lipase activity (GO:0051006)3.62526060
113regulation of bile acid biosynthetic process (GO:0070857)3.61650144
114hemoglobin metabolic process (GO:0020027)3.60954395
115glucuronate metabolic process (GO:0019585)3.58206494
116uronic acid metabolic process (GO:0006063)3.58206494
117protein-lipid complex assembly (GO:0065005)3.58005692
118positive regulation of triglyceride metabolic process (GO:0090208)3.55383534
119DNA strand renaturation (GO:0000733)3.52378485
120negative regulation of lipase activity (GO:0060192)3.50919432
121low-density lipoprotein particle remodeling (GO:0034374)3.50869781
122Golgi transport vesicle coating (GO:0048200)3.50149910
123COPI coating of Golgi vesicle (GO:0048205)3.50149910
124L-serine metabolic process (GO:0006563)3.48729913
125drug transmembrane transport (GO:0006855)3.47836519
126carboxylic acid catabolic process (GO:0046395)3.46885374
127organic acid catabolic process (GO:0016054)3.46885374
128thioester metabolic process (GO:0035383)3.46769655
129acyl-CoA metabolic process (GO:0006637)3.46769655
130negative regulation of fatty acid transport (GO:2000192)3.40391446
131gap junction assembly (GO:0016264)3.37972478
132cellular response to toxic substance (GO:0097237)3.29949049
133positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.29758845
134regulation of cardioblast differentiation (GO:0051890)3.28478670
135cellular response to cadmium ion (GO:0071276)3.27289249
136cellular response to epinephrine stimulus (GO:0071872)3.25761622
137regulation of triglyceride biosynthetic process (GO:0010866)3.25480260
138positive regulation of monooxygenase activity (GO:0032770)3.23578302
139sterol catabolic process (GO:0016127)3.16071074
140cholesterol catabolic process (GO:0006707)3.16071074
141dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.15317139
142cellular response to growth hormone stimulus (GO:0071378)3.13357685
143phagocytosis, recognition (GO:0006910)3.13209929
144planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11692938
145regulation of cholesterol metabolic process (GO:0090181)3.09801014
146mating behavior (GO:0007617)3.01998070
147blood vessel endothelial cell migration (GO:0043534)2.96715796
148* steroid biosynthetic process (GO:0006694)2.92658552
149regulation of male gonad development (GO:2000018)2.91234616
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.89741284
151* cholesterol metabolic process (GO:0008203)2.88764949
152intestinal cholesterol absorption (GO:0030299)2.87949236
153* sterol metabolic process (GO:0016125)2.85202215
154regulation of steroid hormone biosynthetic process (GO:0090030)2.84958506
155cellular response to interferon-alpha (GO:0035457)2.84885462
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84333134
157embryonic process involved in female pregnancy (GO:0060136)2.81791782
158linoleic acid metabolic process (GO:0043651)2.81121591
159fibroblast migration (GO:0010761)2.80833233
160Leydig cell differentiation (GO:0033327)2.77212507
161positive regulation of astrocyte differentiation (GO:0048711)2.73746659
162toxin metabolic process (GO:0009404)2.73643193
163regulation of steroid biosynthetic process (GO:0050810)2.67550518
164estrogen metabolic process (GO:0008210)2.65274789
165regulation of triglyceride metabolic process (GO:0090207)2.65233379
166epithelial cell-cell adhesion (GO:0090136)2.64420751
167positive regulation of lipid storage (GO:0010884)2.63773591
168response to lead ion (GO:0010288)2.62468947
169sterol transport (GO:0015918)2.61047322
170cholesterol transport (GO:0030301)2.61047322
171detection of molecule of bacterial origin (GO:0032490)2.58243818
172bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58160717
173endothelial cell proliferation (GO:0001935)2.55839233
174regulation of apoptotic cell clearance (GO:2000425)2.54542964
175response to corticosterone (GO:0051412)2.54456438
176biotin metabolic process (GO:0006768)2.53349860
177positive regulation of receptor biosynthetic process (GO:0010870)2.53270994
178retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52117950
179regulation of hormone biosynthetic process (GO:0046885)2.51731736
180response to epinephrine (GO:0071871)2.51603747
181thioester biosynthetic process (GO:0035384)2.51598507
182acyl-CoA biosynthetic process (GO:0071616)2.51598507
183glucocorticoid biosynthetic process (GO:0006704)10.5768873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.67210866
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.54182427
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.08289859
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92931459
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.78257336
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.48548696
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25258776
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78869217
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.26370214
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86088351
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46337679
12AR_21909140_ChIP-Seq_LNCAP_Human2.36914114
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12815840
14* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9459045
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88634022
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81536823
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80758758
18* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78400086
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74234731
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72236359
21CLOCK_20551151_ChIP-Seq_293T_Human1.71859880
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62513979
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60332101
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57517092
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55913396
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55212624
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.51983198
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.51533464
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48829365
30HTT_18923047_ChIP-ChIP_STHdh_Human1.47411292
31TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46787386
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43577187
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43275480
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41100047
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.39677984
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38927226
37* KDM2B_26808549_Chip-Seq_K562_Human1.38428666
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38162515
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37159979
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36324465
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33842604
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33825635
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33315348
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.30679199
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30676404
46E2F7_22180533_ChIP-Seq_HELA_Human1.30595904
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.30380918
48ZNF263_19887448_ChIP-Seq_K562_Human1.29405929
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27016354
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20147185
51ATF3_27146783_Chip-Seq_COLON_Human1.20133119
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19279958
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18636585
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.17785670
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.17785670
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17533733
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16206663
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14341220
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.14326529
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14195760
61* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13085777
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12520795
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.08327088
64EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07333839
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05387246
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04620407
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03663859
68CHD1_26751641_Chip-Seq_LNCaP_Human1.03511643
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02600690
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02214128
71* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01812112
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00816447
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00654569
74GATA4_25053715_ChIP-Seq_YYC3_Human1.00450508
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00393197
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97586831
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97586831
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97426954
79RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95915184
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95640157
81NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95116068
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95041637
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94882159
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93998727
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88592664
86* FOXO3_23340844_ChIP-Seq_DLD1_Human0.87301476
87* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87152734
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86875419
89LXR_22292898_ChIP-Seq_THP-1_Human0.84614230
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84103675
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.83899060
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82099866
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80354071
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80354071
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75915959
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75327402
97EGR1_19032775_ChIP-ChIP_M12_Human0.74345999
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73673987
99RACK7_27058665_Chip-Seq_MCF-7_Human0.73295915
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69554904
101CDX2_20551321_ChIP-Seq_CACO-2_Human0.68794633
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68775470
103* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68182836
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67658207
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67292522
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.66358950
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65857187
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65459939
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.65069249
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64405717
111CTCF_27219007_Chip-Seq_Bcells_Human0.64181709
112MYC_19915707_ChIP-ChIP_AK7_Human0.64151415
113SOX2_20726797_ChIP-Seq_SW620_Human0.63047620
114* GATA1_19941826_ChIP-Seq_K562_Human0.62889060
115* FOXA1_25552417_ChIP-Seq_VCAP_Human0.62831605
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.62196209
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62143129
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.59437719
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.59251356
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.58280807
121* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57895827
122* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57830554
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57522850
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57132681
125CEBPB_22108803_ChIP-Seq_LS180_Human0.56934663
126CBP_21632823_ChIP-Seq_H3396_Human0.55879280
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55870925
128CTCF_20526341_ChIP-Seq_ESCs_Human0.55382080
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.54264655
130* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.53427438
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.52990036
132P53_21459846_ChIP-Seq_SAOS-2_Human0.52935566
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.52224378
134* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52080174
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51845524
136TAF15_26573619_Chip-Seq_HEK293_Human0.51831914
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.51593466
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51048765
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50938140
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.50886616
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50682515
142* CREB1_26743006_Chip-Seq_LNCaP_Human0.50600341
143* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49758563
144* ESR1_20079471_ChIP-ChIP_T-47D_Human0.48460430
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.48305085
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.47697711
147* GATA3_24758297_ChIP-Seq_MCF-7_Human0.47001407
148* GATA2_19941826_ChIP-Seq_K562_Human0.46934935
149OCT4_20526341_ChIP-Seq_ESCs_Human0.46872702
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.46754074
151* NCOR_22424771_ChIP-Seq_293T_Human0.46383711
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.46306659
153* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.45787615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.98847119
2MP0005360_urolithiasis7.40946226
3MP0005085_abnormal_gallbladder_physiolo6.05429896
4MP0008004_abnormal_stomach_pH5.92593755
5MP0005365_abnormal_bile_salt5.57662226
6MP0008875_abnormal_xenobiotic_pharmacok4.92526017
7MP0003806_abnormal_nucleotide_metabolis4.48405733
8MP0003252_abnormal_bile_duct3.65268566
9MP0009840_abnormal_foam_cell3.34093576
10MP0005083_abnormal_biliary_tract3.30388941
11MP0010329_abnormal_lipoprotein_level3.27364452
12MP0003195_calcinosis2.70668963
13MP0005332_abnormal_amino_acid2.69761876
14MP0001666_abnormal_nutrient_absorption2.55597318
15MP0004233_abnormal_muscle_weight2.54088584
16MP0003300_gastrointestinal_ulcer2.45483296
17MP0003566_abnormal_cell_adhesion2.42948675
18MP0002877_abnormal_melanocyte_morpholog2.37997352
19MP0004272_abnormal_basement_membrane2.37835409
20MP0004782_abnormal_surfactant_physiolog2.31104591
21MP0002909_abnormal_adrenal_gland2.16109345
22MP0003191_abnormal_cellular_cholesterol2.14186744
23MP0004019_abnormal_vitamin_homeostasis2.12565079
24MP0003941_abnormal_skin_development2.10214052
25MP0005076_abnormal_cell_differentiation2.07110674
26* MP0002118_abnormal_lipid_homeostasis2.05257296
27MP0000609_abnormal_liver_physiology1.93852753
28MP0000566_synostosis1.93124886
29MP0005451_abnormal_body_composition1.91593010
30MP0003868_abnormal_feces_composition1.83092719
31MP0003705_abnormal_hypodermis_morpholog1.61075849
32MP0003011_delayed_dark_adaptation1.59473672
33MP0001849_ear_inflammation1.58559458
34MP0002896_abnormal_bone_mineralization1.55422781
35MP0003329_amyloid_beta_deposits1.53938982
36MP0005584_abnormal_enzyme/coenzyme_acti1.52078052
37MP0002138_abnormal_hepatobiliary_system1.51693365
38MP0005319_abnormal_enzyme/_coenzyme1.50578050
39MP0000604_amyloidosis1.48106326
40MP0000537_abnormal_urethra_morphology1.46220028
41MP0002796_impaired_skin_barrier1.45056286
42MP0000678_abnormal_parathyroid_gland1.41462940
43MP0010352_gastrointestinal_tract_polyps1.37379925
44MP0004858_abnormal_nervous_system1.33551736
45MP0003690_abnormal_glial_cell1.32341283
46MP0000579_abnormal_nail_morphology1.28861132
47MP0005257_abnormal_intraocular_pressure1.27472991
48MP0005409_darkened_coat_color1.26644763
49MP0002089_abnormal_postnatal_growth/wei1.24860834
50MP0003656_abnormal_erythrocyte_physiolo1.19960792
51MP0009780_abnormal_chondrocyte_physiolo1.19175968
52MP0002254_reproductive_system_inflammat1.18774021
53MP0009643_abnormal_urine_homeostasis1.18050327
54MP0000762_abnormal_tongue_morphology1.16792509
55MP0003315_abnormal_perineum_morphology1.16321021
56MP0000920_abnormal_myelination1.12273989
57MP0003122_maternal_imprinting1.11051196
58MP0001764_abnormal_homeostasis1.09789670
59MP0001881_abnormal_mammary_gland1.09418239
60MP0000627_abnormal_mammary_gland1.09018061
61MP0003091_abnormal_cell_migration1.08268542
62MP0008438_abnormal_cutaneous_collagen1.08236705
63MP0005023_abnormal_wound_healing1.06547768
64MP0005623_abnormal_meninges_morphology1.05583967
65MP0005508_abnormal_skeleton_morphology1.04736275
66MP0000598_abnormal_liver_morphology0.99588814
67MP0001915_intracranial_hemorrhage0.98480379
68MP0001730_embryonic_growth_arrest0.98153797
69MP0001661_extended_life_span0.97915121
70MP0005408_hypopigmentation0.97662220
71MP0002697_abnormal_eye_size0.96621767
72MP0003186_abnormal_redox_activity0.94138711
73MP0009053_abnormal_anal_canal0.90783077
74MP0009697_abnormal_copulation0.90098555
75MP0005187_abnormal_penis_morphology0.86437857
76MP0005647_abnormal_sex_gland0.86103449
77MP0003890_abnormal_embryonic-extraembry0.86012277
78MP0004381_abnormal_hair_follicle0.85566276
79MP0002269_muscular_atrophy0.84844835
80MP0005636_abnormal_mineral_homeostasis0.84396853
81MP0002088_abnormal_embryonic_growth/wei0.80801848
82MP0008007_abnormal_cellular_replicative0.80688495
83MP0010630_abnormal_cardiac_muscle0.80553221
84MP0000647_abnormal_sebaceous_gland0.80374045
85MP0010030_abnormal_orbit_morphology0.79581336
86MP0003123_paternal_imprinting0.78899981
87MP0002084_abnormal_developmental_patter0.77532251
88MP0005380_embryogenesis_phenotype0.77328487
89MP0001672_abnormal_embryogenesis/_devel0.77328487
90MP0009763_increased_sensitivity_to0.77187460
91MP0010678_abnormal_skin_adnexa0.75221202
92MP0005375_adipose_tissue_phenotype0.75068034
93MP0003984_embryonic_growth_retardation0.74407673
94MP0010234_abnormal_vibrissa_follicle0.72939067
95MP0001851_eye_inflammation0.71210465
96MP0009765_abnormal_xenobiotic_induced0.71187828
97MP0003385_abnormal_body_wall0.70829205
98MP0005501_abnormal_skin_physiology0.70678665
99MP0004883_abnormal_blood_vessel0.70292250
100MP0002086_abnormal_extraembryonic_tissu0.69438367
101MP0009250_abnormal_appendicular_skeleto0.67663102
102* MP0009642_abnormal_blood_homeostasis0.67620943
103MP0002090_abnormal_vision0.67559585
104MP0000003_abnormal_adipose_tissue0.67482765
105* MP0002080_prenatal_lethality0.65763233
106MP0001299_abnormal_eye_distance/0.65491537
107MP0008260_abnormal_autophagy0.65478811
108MP0003953_abnormal_hormone_level0.63333870
109MP0003453_abnormal_keratinocyte_physiol0.62850843
110MP0000467_abnormal_esophagus_morphology0.61803197
111MP0004185_abnormal_adipocyte_glucose0.61771386
112MP0002971_abnormal_brown_adipose0.61167516
113MP0003632_abnormal_nervous_system0.60811004
114MP0000462_abnormal_digestive_system0.60376390
115MP0009764_decreased_sensitivity_to0.59938562
116MP0000639_abnormal_adrenal_gland0.59855758
117MP0005376_homeostasis/metabolism_phenot0.58591338
118MP0001243_abnormal_dermal_layer0.55603950
119MP0000377_abnormal_hair_follicle0.54599283
120MP0005220_abnormal_exocrine_pancreas0.54080296
121MP0010368_abnormal_lymphatic_system0.53687874
122MP0008469_abnormal_protein_level0.53661210
123MP0000383_abnormal_hair_follicle0.52849565
124MP0002078_abnormal_glucose_homeostasis0.51795921
125MP0000427_abnormal_hair_cycle0.51083977
126MP0004885_abnormal_endolymph0.50764127
127MP0006036_abnormal_mitochondrial_physio0.49770762
128MP0002098_abnormal_vibrissa_morphology0.49767829
129MP0009672_abnormal_birth_weight0.49250588
130MP0005266_abnormal_metabolism0.49125071
131MP0001756_abnormal_urination0.49108108
132MP0002822_catalepsy0.48877485
133MP0005395_other_phenotype0.47245188
134MP0002060_abnormal_skin_morphology0.47167051
135MP0005666_abnormal_adipose_tissue0.46395458
136MP0008874_decreased_physiological_sensi0.46184176
137MP0005448_abnormal_energy_balance0.44259645
138MP0005248_abnormal_Harderian_gland0.43842095
139MP0005535_abnormal_body_temperature0.43773070
140MP0004130_abnormal_muscle_cell0.43496206
141MP0003718_maternal_effect0.42717386
142MP0001216_abnormal_epidermal_layer0.42183097
143* MP0005334_abnormal_fat_pad0.41863877
144MP0008873_increased_physiological_sensi0.40060851
145MP0003638_abnormal_response/metabolism_0.40011499
146MP0009384_cardiac_valve_regurgitation0.39664529
147MP0005275_abnormal_skin_tensile0.39658170
148MP0010771_integument_phenotype0.39329725
149MP0002136_abnormal_kidney_physiology0.39000554
150MP0003075_altered_response_to0.37998308
151MP0002876_abnormal_thyroid_physiology0.37250550
152MP0006035_abnormal_mitochondrial_morpho0.37120283
153MP0005058_abnormal_lysosome_morphology0.35641764
154MP0004264_abnormal_extraembryonic_tissu0.34362595
155MP0004043_abnormal_pH_regulation0.33567799
156MP0005084_abnormal_gallbladder_morpholo0.32997497
157MP0003631_nervous_system_phenotype0.32250083
158MP0001340_abnormal_eyelid_morphology0.31821880

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.28771340
2Intrahepatic cholestasis (HP:0001406)7.25927333
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98122538
4Xanthomatosis (HP:0000991)6.30446482
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27158198
6Hypobetalipoproteinemia (HP:0003563)6.08992140
7Prolonged partial thromboplastin time (HP:0003645)5.72992815
8Hyperlipoproteinemia (HP:0010980)5.34979330
9Complement deficiency (HP:0004431)4.63842703
10Epidermoid cyst (HP:0200040)4.59941485
11Hypolipoproteinemia (HP:0010981)4.43100030
12Hyperammonemia (HP:0001987)4.20312817
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12974351
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.08808579
15Abnormality of methionine metabolism (HP:0010901)4.05641198
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04293524
17Joint hemorrhage (HP:0005261)4.03301693
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99218540
19Abnormality of the common coagulation pathway (HP:0010990)3.97275496
20Fat malabsorption (HP:0002630)3.94404259
21Hyperglycinemia (HP:0002154)3.92682452
22Renal salt wasting (HP:0000127)3.91547621
23Ketosis (HP:0001946)3.82740898
24Abnormality of glycine metabolism (HP:0010895)3.77887625
25Abnormality of serine family amino acid metabolism (HP:0010894)3.77887625
26Hypoalphalipoproteinemia (HP:0003233)3.73617215
27Abnormality of carpal bone ossification (HP:0006257)3.56198719
28Ulnar bowing (HP:0003031)3.47297934
29Hyperglycinuria (HP:0003108)3.40767970
30Hypercholesterolemia (HP:0003124)3.36842661
31Abnormality of complement system (HP:0005339)3.36305726
32Conjugated hyperbilirubinemia (HP:0002908)3.32947598
33Abnormality of pyrimidine metabolism (HP:0004353)3.20439729
34Vertebral arch anomaly (HP:0008438)3.17212917
35Ureteral duplication (HP:0000073)3.12562816
36Flat acetabular roof (HP:0003180)3.12359993
37Abnormality of the intrinsic pathway (HP:0010989)3.06693197
38Hypoglycemic coma (HP:0001325)3.04592085
39Abnormal ossification of hand bones (HP:0005921)3.03048617
40Acanthosis nigricans (HP:0000956)3.02794800
41Hyperbilirubinemia (HP:0002904)2.96231669
42Delayed CNS myelination (HP:0002188)2.95929723
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95813829
44Diastasis recti (HP:0001540)2.95603878
45Steatorrhea (HP:0002570)2.93457168
46Short nail (HP:0001799)2.91124436
47Abnormality of fatty-acid metabolism (HP:0004359)2.82753594
48Vertebral clefting (HP:0008428)2.78699393
49Spontaneous abortion (HP:0005268)2.70452795
50Neurofibrillary tangles (HP:0002185)2.70307243
51Small epiphyses (HP:0010585)2.69140825
52Hepatocellular carcinoma (HP:0001402)2.67923801
53Abnormality of nucleobase metabolism (HP:0010932)2.67468196
54Abnormal hand bone ossification (HP:0010660)2.66735280
55Acanthocytosis (HP:0001927)2.65446191
56Aplasia involving bones of the upper limbs (HP:0009823)2.65311813
57Aplasia of the phalanges of the hand (HP:0009802)2.65311813
58Aplasia involving bones of the extremities (HP:0009825)2.65311813
59Vascular calcification (HP:0004934)2.64739568
60Skin nodule (HP:0200036)2.63806064
61Myelomeningocele (HP:0002475)2.61775418
62Cholecystitis (HP:0001082)2.60910959
63Abnormal gallbladder physiology (HP:0012438)2.60910959
64Protrusio acetabuli (HP:0003179)2.60324183
65Spastic diplegia (HP:0001264)2.58675743
66Abnormality of serum amino acid levels (HP:0003112)2.57529108
67Abnormal gallbladder morphology (HP:0012437)2.56602415
68Ketoacidosis (HP:0001993)2.52778934
69Myocardial infarction (HP:0001658)2.51672042
70Malnutrition (HP:0004395)2.50458270
71Right ventricular cardiomyopathy (HP:0011663)2.49534004
72Growth hormone excess (HP:0000845)2.48117386
73Bronchomalacia (HP:0002780)2.46397468
74Hypochromic microcytic anemia (HP:0004840)2.44656250
75Cerebral inclusion bodies (HP:0100314)2.42963673
76Amyloidosis (HP:0011034)2.42808786
77Cerebral palsy (HP:0100021)2.42477183
78Cholelithiasis (HP:0001081)2.41519035
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41085577
80Abnormality of purine metabolism (HP:0004352)2.40982430
81Sex reversal (HP:0012245)2.40653915
82Abnormal sex determination (HP:0012244)2.40653915
83Irritability (HP:0000737)2.38607769
84Metabolic acidosis (HP:0001942)2.38157359
85Cardiovascular calcification (HP:0011915)2.36305441
86Hypoplasia of dental enamel (HP:0006297)2.36081274
87Stenosis of the external auditory canal (HP:0000402)2.35880289
88Precocious puberty (HP:0000826)2.32795858
89Neonatal onset (HP:0003623)2.32746845
90Rickets (HP:0002748)2.32045124
91Hypophosphatemic rickets (HP:0004912)2.30642867
92Short clavicles (HP:0000894)2.30608455
93Lethargy (HP:0001254)2.28933163
94Gout (HP:0001997)2.26760542
95Anteriorly placed anus (HP:0001545)2.25409103
96Cervical subluxation (HP:0003308)2.23973041
97Flattened epiphyses (HP:0003071)2.23469332
98Advanced eruption of teeth (HP:0006288)2.21091596
99Split foot (HP:0001839)2.19289886
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18899326
101Dicarboxylic aciduria (HP:0003215)2.18899326
102Hemorrhage of the eye (HP:0011885)2.17714995
103Abnormality of the aortic arch (HP:0012303)2.15710616
104Mitral stenosis (HP:0001718)2.14927025
105Deviation of the thumb (HP:0009603)2.14582346
106Abnormality of the gallbladder (HP:0005264)2.12428741
107Abnormal tarsal ossification (HP:0008369)2.12207396
108Bowed forearm bones (HP:0003956)2.10021986
109Bowing of the arm (HP:0006488)2.10021986
110Arnold-Chiari malformation (HP:0002308)2.09826728
111Aplasia/Hypoplasia of the clavicles (HP:0006710)2.07301499
112Brushfield spots (HP:0001088)2.07176040
113Abnormality of the Achilles tendon (HP:0005109)2.06975698
114Alkalosis (HP:0001948)2.06230532
115Cerebral edema (HP:0002181)2.05596061
116Enlarged penis (HP:0000040)2.04467648
117Hyperaldosteronism (HP:0000859)2.04231580
118Spinal cord compression (HP:0002176)2.02932593
119Broad face (HP:0000283)2.01438684
120Turricephaly (HP:0000262)2.01194632
121Glomerulonephritis (HP:0000099)2.00708761
122Premature rupture of membranes (HP:0001788)2.00672095
123Esophageal varix (HP:0002040)2.00360443
124Systemic lupus erythematosus (HP:0002725)2.00310471
125Spastic paraparesis (HP:0002313)1.99568764
126Abnormality of the fetal cardiovascular system (HP:0010948)1.98688122
127Abnormal umbilical cord blood vessels (HP:0011403)1.98688122
128Single umbilical artery (HP:0001195)1.98688122
129Back pain (HP:0003418)1.96749363
130Accelerated skeletal maturation (HP:0005616)1.96032260
131Sensorimotor neuropathy (HP:0007141)1.95919755
132Pseudobulbar signs (HP:0002200)1.95490484
133Increased serum pyruvate (HP:0003542)1.95413837
134Abnormality of glycolysis (HP:0004366)1.95413837
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.95172568
136Abnormality of dentin (HP:0010299)1.95026569
137Limited elbow extension (HP:0001377)1.94517935
138Abnormality of the corticospinal tract (HP:0002492)1.93898775
139Insidious onset (HP:0003587)1.92185055
140Termporal pattern (HP:0011008)1.92185055
141Supernumerary nipples (HP:0002558)1.91350546
142Spinal cord lesions (HP:0100561)1.91205585
143Syringomyelia (HP:0003396)1.91205585
144Mixed hearing impairment (HP:0000410)1.91125561
145Abnormality of vitamin metabolism (HP:0100508)1.90952491
146Enlarged kidneys (HP:0000105)1.90914134
147Abnormal cartilage morphology (HP:0002763)1.90913024
148Hypoglycemic seizures (HP:0002173)1.90865731
149Abnormal enzyme/coenzyme activity (HP:0012379)1.89959655
150Insulin resistance (HP:0000855)1.88973689
151Vomiting (HP:0002013)1.88511628
152Bifid scrotum (HP:0000048)1.88052730
153Parakeratosis (HP:0001036)1.87375969
154Oligodontia (HP:0000677)1.86805915
155Seborrheic dermatitis (HP:0001051)1.85131059
156Gingival bleeding (HP:0000225)1.84399304
157Pterygium (HP:0001059)1.84254660
158Hypoplastic scapulae (HP:0000882)1.83718874
159Aplasia/Hypoplasia of the scapulae (HP:0006713)1.83718874
160Absent epiphyses (HP:0010577)1.83600400
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83600400
162Hypospadias (HP:0000047)1.83444083
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83154938
164Degeneration of the lateral corticospinal tracts (HP:0002314)1.83154938
165Abnormality of the umbilical cord (HP:0010881)1.81589912
166Neonatal death (HP:0003811)1.81181567
167Hyperpituitarism (HP:0010514)1.80430584
168Opisthotonus (HP:0002179)1.80277024
169Abnormality of permanent molar morphology (HP:0011071)1.78532402
170Abnormality of the dental root (HP:0006486)1.78532402
171Taurodontia (HP:0000679)1.78532402
172Osteomalacia (HP:0002749)1.77386865
173* Rhizomelia (HP:0008905)1.76172264
174Confusion (HP:0001289)1.75684245
175Late onset (HP:0003584)1.75574883
176Hyperacusis (HP:0010780)1.73962331
177Coxa vara (HP:0002812)1.72202151
178Testicular neoplasm (HP:0010788)1.70443821
179Shallow orbits (HP:0000586)1.68227865
180Abnormal vertebral ossification (HP:0100569)1.68225118
181Short humerus (HP:0005792)1.68006922
182Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68005631
183Hypoplastic nipples (HP:0002557)1.66502791
184Asymmetry of the thorax (HP:0001555)1.65618702
185Abnormal foot bone ossification (HP:0010675)1.65379403
18611 pairs of ribs (HP:0000878)1.65052792
187Wormian bones (HP:0002645)1.64947166
188Proximal placement of thumb (HP:0009623)1.64815153
189Natal tooth (HP:0000695)1.63909439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.34511822
2BCKDK4.71297157
3STK393.86814993
4EPHB13.78036985
5SIK13.48335609
6FGFR43.30846058
7TAOK23.02206326
8ERN12.97620862
9SMG12.69223946
10ERBB42.67038209
11MET2.57678044
12OXSR12.49569787
13FGFR22.47415500
14EEF2K2.37262593
15ICK2.30786340
16MST1R2.20482111
17WNK42.14884204
18CDK122.04763216
19PKN21.94689211
20MAP2K41.70978691
21PBK1.69338193
22TRIB31.61747372
23AKT31.55565139
24NTRK11.50896378
25LMTK21.45185832
26PTK61.42871008
27LATS11.35686309
28PKN11.35041317
29PAK41.32801834
30PRKD31.25857723
31CSNK1G31.22734990
32TAOK31.22205076
33ABL21.22080461
34BCR1.21262523
35MAP3K21.19354509
36KSR21.18104947
37ERBB21.16423607
38CSNK1G11.16377489
39PTK21.16083331
40JAK11.16007443
41CDK71.15956990
42BMX1.11338021
43MAP3K101.10723979
44TSSK61.10707030
45MAP3K71.10225457
46SCYL21.08682773
47CSNK1A1L1.07514558
48TESK11.07217934
49PIK3CG1.06735248
50PDK21.06185492
51TYRO31.05904406
52INSRR1.05495940
53MAPK111.05461549
54PAK61.01156115
55CSNK1G20.98872498
56DAPK20.98401656
57GRK60.97884229
58TTN0.97831197
59TTK0.96404781
60MAP3K90.94486232
61PAK30.94159006
62GSK3A0.93105751
63MAP2K20.92483568
64LATS20.91801513
65MELK0.90706688
66TESK20.89654566
67RET0.88948781
68ARAF0.86932154
69PRKCZ0.82959124
70EIF2AK10.80582067
71EPHB20.80419169
72CAMK40.80410820
73DMPK0.80335647
74EPHA20.78367293
75AKT20.76810661
76PDPK10.76337716
77WNK10.73381111
78FGFR30.71252978
79NEK90.70787298
80CAMK2G0.70665340
81FGR0.70340879
82CAMK1G0.69172484
83LIMK10.68953528
84JAK20.67808016
85FGFR10.67209148
86CAMK1D0.65757995
87IRAK30.65402241
88UHMK10.65260327
89FLT30.65050452
90SGK2230.64822146
91SGK4940.64822146
92MTOR0.64465573
93NEK60.63189992
94MAPK40.62807321
95PRKCQ0.62431554
96PRKAA20.61296919
97PRKACG0.58963848
98CSK0.58016494
99STK380.57901441
100STK100.57232645
101RPS6KA20.56664249
102CDC42BPA0.55758324
103MAPK150.55358643
104CSNK1E0.52871573
105MAP2K10.52717342
106PAK20.52135238
107FER0.52118230
108CSNK1D0.52106023
109EPHA40.50876512
110MAP3K60.50591307
111ROCK20.50019684
112MAP3K50.48718426
113CDK60.48325014
114EPHA30.47818023
115DYRK1B0.46453864
116CDK150.46114581
117DYRK20.45872333
118MAPKAPK50.45134010
119RIPK10.44930505
120CDK90.44108864
121CDK180.44038337
122PRKD10.43209322
123MAPKAPK30.42723264
124PDGFRB0.41544452
125RPS6KB20.41314436
126SGK30.40221532
127DDR20.38375190
128KDR0.38313877
129CDK11A0.37741849
130FYN0.36650543
131STK38L0.36628338
132EGFR0.35890582
133MAPK120.35628813
134ALK0.35064896
135MAP3K110.34776643
136PDGFRA0.33318058
137PDK10.33206499
138MAPK100.32942280
139LRRK20.32901269
140PLK30.31892259
141BRAF0.31312297
142MAPK30.30934759
143NEK10.30291708
144PRKACB0.30227071
145MARK20.29710244
146MAP3K80.29276144
147IRAK20.29127820
148TAF10.29110126
149ROCK10.29092076
150PRKD20.28820770
151CAMK2B0.28384752
152MAP3K10.27994851
153TYK20.27820472
154CDK140.27679205

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.05602843
2Nitrogen metabolism_Homo sapiens_hsa009103.57369517
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.28571849
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17938230
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99938332
6Arginine biosynthesis_Homo sapiens_hsa002202.80373327
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56925470
8Tryptophan metabolism_Homo sapiens_hsa003802.51871707
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50430609
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47426365
11Butanoate metabolism_Homo sapiens_hsa006502.46006143
12Complement and coagulation cascades_Homo sapiens_hsa046102.39882725
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38512972
14Fatty acid degradation_Homo sapiens_hsa000712.34809663
15* Steroid biosynthesis_Homo sapiens_hsa001002.34336544
16Fatty acid elongation_Homo sapiens_hsa000622.19038483
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15843845
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11426043
19Histidine metabolism_Homo sapiens_hsa003402.07815085
20Fatty acid metabolism_Homo sapiens_hsa012122.03688560
21Aldosterone synthesis and secretion_Homo sapiens_hsa049252.03015867
22Peroxisome_Homo sapiens_hsa041462.00187489
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99549097
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.90026628
25Propanoate metabolism_Homo sapiens_hsa006401.88781897
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86059502
27Chemical carcinogenesis_Homo sapiens_hsa052041.85939051
28PPAR signaling pathway_Homo sapiens_hsa033201.77507890
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69322919
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67464289
31Retinol metabolism_Homo sapiens_hsa008301.63785393
32beta-Alanine metabolism_Homo sapiens_hsa004101.62990771
33Bile secretion_Homo sapiens_hsa049761.57849570
34Sulfur metabolism_Homo sapiens_hsa009201.54778572
35Phenylalanine metabolism_Homo sapiens_hsa003601.47903205
36Pyruvate metabolism_Homo sapiens_hsa006201.44244891
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.43386466
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42643203
39Staphylococcus aureus infection_Homo sapiens_hsa051501.42544358
40Tyrosine metabolism_Homo sapiens_hsa003501.39646100
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38064246
42Caffeine metabolism_Homo sapiens_hsa002321.36822859
43Selenocompound metabolism_Homo sapiens_hsa004501.31313187
44Fat digestion and absorption_Homo sapiens_hsa049751.27276442
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24014156
46Thyroid cancer_Homo sapiens_hsa052161.21587298
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.14093661
48Adherens junction_Homo sapiens_hsa045201.13940542
49Biosynthesis of amino acids_Homo sapiens_hsa012301.12747409
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.12006630
51Arginine and proline metabolism_Homo sapiens_hsa003301.10856492
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10152077
53Starch and sucrose metabolism_Homo sapiens_hsa005001.06696142
54ABC transporters_Homo sapiens_hsa020101.06284515
55Carbon metabolism_Homo sapiens_hsa012001.05081639
56Folate biosynthesis_Homo sapiens_hsa007901.02510736
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98865471
58Vitamin B6 metabolism_Homo sapiens_hsa007500.95441279
59Vitamin digestion and absorption_Homo sapiens_hsa049770.95026077
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91733124
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87560186
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86536754
63Glutathione metabolism_Homo sapiens_hsa004800.83192295
64Sulfur relay system_Homo sapiens_hsa041220.82747298
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81834204
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.79459080
67Proteoglycans in cancer_Homo sapiens_hsa052050.79298495
68Lysine degradation_Homo sapiens_hsa003100.79055081
69Fatty acid biosynthesis_Homo sapiens_hsa000610.77743834
70Endometrial cancer_Homo sapiens_hsa052130.77372459
71Focal adhesion_Homo sapiens_hsa045100.76006711
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75948641
73Glycerolipid metabolism_Homo sapiens_hsa005610.70014047
74N-Glycan biosynthesis_Homo sapiens_hsa005100.69876080
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.67115976
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67027181
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65942958
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60073927
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53436413
80ErbB signaling pathway_Homo sapiens_hsa040120.53096787
81Hippo signaling pathway_Homo sapiens_hsa043900.51993531
82Pentose phosphate pathway_Homo sapiens_hsa000300.51954712
83One carbon pool by folate_Homo sapiens_hsa006700.49053200
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47348717
85MicroRNAs in cancer_Homo sapiens_hsa052060.46993186
86Vibrio cholerae infection_Homo sapiens_hsa051100.45130446
87* Metabolic pathways_Homo sapiens_hsa011000.44166131
88Linoleic acid metabolism_Homo sapiens_hsa005910.44160321
89Other glycan degradation_Homo sapiens_hsa005110.44087302
90Small cell lung cancer_Homo sapiens_hsa052220.43368337
91Chronic myeloid leukemia_Homo sapiens_hsa052200.43095234
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42919287
93Renal cell carcinoma_Homo sapiens_hsa052110.42676607
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41977907
95Choline metabolism in cancer_Homo sapiens_hsa052310.41336904
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40595178
97Wnt signaling pathway_Homo sapiens_hsa043100.38540242
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37088469
99Notch signaling pathway_Homo sapiens_hsa043300.36315181
100Estrogen signaling pathway_Homo sapiens_hsa049150.36089877
101mTOR signaling pathway_Homo sapiens_hsa041500.35500170
102Prostate cancer_Homo sapiens_hsa052150.34928216
103Prion diseases_Homo sapiens_hsa050200.31678257
104Ether lipid metabolism_Homo sapiens_hsa005650.29592034
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.25315112
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24760072
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17017563
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.16320958
109Insulin resistance_Homo sapiens_hsa049310.10620865
110Fructose and mannose metabolism_Homo sapiens_hsa000510.08293957
111Ovarian steroidogenesis_Homo sapiens_hsa049130.05321834
112AMPK signaling pathway_Homo sapiens_hsa041520.02435935
113Galactose metabolism_Homo sapiens_hsa000520.02265871
114ECM-receptor interaction_Homo sapiens_hsa04512-0.2243343
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2226695
116Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1840182
117Amoebiasis_Homo sapiens_hsa05146-0.1753022
118Sphingolipid metabolism_Homo sapiens_hsa00600-0.1731823
119Tight junction_Homo sapiens_hsa04530-0.1715637
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1688206
121Protein digestion and absorption_Homo sapiens_hsa04974-0.1635256
122Hepatitis C_Homo sapiens_hsa05160-0.1577178
123Renin-angiotensin system_Homo sapiens_hsa04614-0.1538759
124Bladder cancer_Homo sapiens_hsa05219-0.1367467
125Axon guidance_Homo sapiens_hsa04360-0.1270383
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1199678
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1126005
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0982517
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0867316
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0842726
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0780034
132Glucagon signaling pathway_Homo sapiens_hsa04922-0.0540871
133Mineral absorption_Homo sapiens_hsa04978-0.0537882

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