DHFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.70235479
2DNA strand elongation (GO:0022616)5.43256213
3DNA unwinding involved in DNA replication (GO:0006268)5.41391466
4telomere maintenance via semi-conservative replication (GO:0032201)5.36246561
5DNA replication initiation (GO:0006270)5.28328654
6telomere maintenance via recombination (GO:0000722)4.74041161
7DNA replication checkpoint (GO:0000076)4.68682568
8mitotic recombination (GO:0006312)4.55250801
9nucleobase biosynthetic process (GO:0046112)4.33166703
10CENP-A containing nucleosome assembly (GO:0034080)4.31050039
11chromatin remodeling at centromere (GO:0031055)4.26533770
12purine nucleobase biosynthetic process (GO:0009113)4.14882897
13heterochromatin organization (GO:0070828)4.13919814
14nucleotide-excision repair, DNA gap filling (GO:0006297)4.13641106
15telomere maintenance via telomere lengthening (GO:0010833)4.10519574
16mitotic sister chromatid cohesion (GO:0007064)4.09143762
17DNA topological change (GO:0006265)4.08290976
18DNA replication-dependent nucleosome organization (GO:0034723)4.01580084
19DNA replication-dependent nucleosome assembly (GO:0006335)4.01580084
20protein localization to kinetochore (GO:0034501)3.97376747
21ribosomal small subunit assembly (GO:0000028)3.96813013
22* folic acid-containing compound biosynthetic process (GO:0009396)3.88203952
23DNA replication-independent nucleosome assembly (GO:0006336)3.80538330
24DNA replication-independent nucleosome organization (GO:0034724)3.80538330
25maturation of SSU-rRNA (GO:0030490)3.79901734
26* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79822062
27chromosome condensation (GO:0030261)3.77722007
28kinetochore organization (GO:0051383)3.72335395
29IMP biosynthetic process (GO:0006188)3.69741489
30mitotic metaphase plate congression (GO:0007080)3.69657605
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64237548
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57705339
33DNA deamination (GO:0045006)3.55813208
34pore complex assembly (GO:0046931)3.55325029
35regulation of translational fidelity (GO:0006450)3.55067476
36meiotic chromosome segregation (GO:0045132)3.54781730
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53500249
38viral transcription (GO:0019083)3.51898569
39DNA ligation (GO:0006266)3.51844569
40translational termination (GO:0006415)3.50051799
41regulation of centriole replication (GO:0046599)3.49378517
42histone exchange (GO:0043486)3.48891160
43viral life cycle (GO:0019058)3.48431739
44formation of translation preinitiation complex (GO:0001731)3.47110130
45protein localization to endoplasmic reticulum (GO:0070972)3.47038415
46protein complex disassembly (GO:0043241)3.44590352
47mitotic nuclear envelope disassembly (GO:0007077)3.38950218
48protein localization to chromosome, centromeric region (GO:0071459)3.38121618
49deoxyribonucleotide biosynthetic process (GO:0009263)3.34789359
50* glycine metabolic process (GO:0006544)3.34476695
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33895795
52ribosomal large subunit biogenesis (GO:0042273)3.33567775
53L-serine metabolic process (GO:0006563)3.31188440
54kinetochore assembly (GO:0051382)3.30801252
55establishment of viral latency (GO:0019043)3.30407226
56DNA packaging (GO:0006323)3.28840683
57regulation of DNA endoreduplication (GO:0032875)3.28431657
58macromolecular complex disassembly (GO:0032984)3.27620796
59metaphase plate congression (GO:0051310)3.26836666
60IMP metabolic process (GO:0046040)3.24834470
61mitotic chromosome condensation (GO:0007076)3.24338129
62ribosomal small subunit biogenesis (GO:0042274)3.24219228
63chromosome segregation (GO:0007059)3.24210024
64pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.24014861
65translational elongation (GO:0006414)3.23290861
66non-recombinational repair (GO:0000726)3.23086017
67double-strand break repair via nonhomologous end joining (GO:0006303)3.23086017
68ribosome assembly (GO:0042255)3.22720089
69* serine family amino acid biosynthetic process (GO:0009070)3.22319962
70DNA conformation change (GO:0071103)3.20800859
71* tetrahydrofolate metabolic process (GO:0046653)3.20792857
72positive regulation of chromosome segregation (GO:0051984)3.20721000
73nuclear pore organization (GO:0006999)3.20413330
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.15364835
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15364835
76ribonucleoprotein complex biogenesis (GO:0022613)3.14528275
77DNA duplex unwinding (GO:0032508)3.11590712
78DNA geometric change (GO:0032392)3.11050119
79translational initiation (GO:0006413)3.09920531
80spliceosomal snRNP assembly (GO:0000387)3.09421884
81regulation of chromosome segregation (GO:0051983)3.09379424
82transcription-coupled nucleotide-excision repair (GO:0006283)3.09299677
83telomere organization (GO:0032200)3.09051595
84telomere maintenance (GO:0000723)3.08927033
85ribosome biogenesis (GO:0042254)3.08819736
86nuclear envelope disassembly (GO:0051081)3.08441761
87membrane disassembly (GO:0030397)3.08441761
88proteasome assembly (GO:0043248)3.07285448
89establishment of integrated proviral latency (GO:0075713)3.07038308
90attachment of spindle microtubules to kinetochore (GO:0008608)3.05926340
91negative regulation of chromosome segregation (GO:0051985)3.05184151
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05165395
93negative regulation of RNA splicing (GO:0033119)3.04790730
94regulation of double-strand break repair via homologous recombination (GO:0010569)3.03304939
95mismatch repair (GO:0006298)3.01700653
96negative regulation of mRNA processing (GO:0050686)3.00782401
97regulation of sister chromatid cohesion (GO:0007063)2.99909508
98DNA strand renaturation (GO:0000733)2.99094081
99translesion synthesis (GO:0019985)2.98494810
100chromatin assembly or disassembly (GO:0006333)2.98342293
101* G1/S transition of mitotic cell cycle (GO:0000082)2.96802623
102* cell cycle G1/S phase transition (GO:0044843)2.96802623
103chromatin assembly (GO:0031497)2.96751903
104DNA synthesis involved in DNA repair (GO:0000731)2.96640896
105pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.94529718
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93074005
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92862559
108nuclear-transcribed mRNA catabolic process (GO:0000956)2.92520846
109negative regulation of sister chromatid segregation (GO:0033046)2.91204611
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91204611
111nuclear pore complex assembly (GO:0051292)2.90714115
112* folic acid metabolic process (GO:0046655)2.90287392
113rRNA processing (GO:0006364)2.89454728
114mitotic sister chromatid segregation (GO:0000070)2.88252266
115pseudouridine synthesis (GO:0001522)2.86509791
116cotranslational protein targeting to membrane (GO:0006613)2.85045703
117protein targeting to ER (GO:0045047)2.84017992
118establishment of chromosome localization (GO:0051303)2.82923876
119* pteridine-containing compound biosynthetic process (GO:0042559)2.81793288
120DNA replication (GO:0006260)2.80577198
121rRNA metabolic process (GO:0016072)2.78519331
122* folic acid-containing compound metabolic process (GO:0006760)2.78366326
123spliceosomal complex assembly (GO:0000245)2.76472781
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.75235549
125* serine family amino acid metabolic process (GO:0009069)2.74644765
126regulation of centrosome cycle (GO:0046605)2.72825584
127deoxyribose phosphate biosynthetic process (GO:0046385)2.72783315
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.72783315
129nucleoside salvage (GO:0043174)2.72781886
130base-excision repair (GO:0006284)2.72590439
131sister chromatid segregation (GO:0000819)2.71964378
132ATP-dependent chromatin remodeling (GO:0043044)2.70819198
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70713313
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70614110
135postreplication repair (GO:0006301)2.69647836
136cellular protein complex disassembly (GO:0043624)2.68653025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.19837321
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85872271
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77963382
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.75082568
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23987165
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14035163
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77242739
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77060612
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.76146161
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73378282
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65327460
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.58518705
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54521806
14* AR_21909140_ChIP-Seq_LNCAP_Human2.51209371
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.47029000
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29627537
17XRN2_22483619_ChIP-Seq_HELA_Human2.20822151
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17105481
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15532598
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12978677
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11888176
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.11327504
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03783025
24VDR_23849224_ChIP-Seq_CD4+_Human2.00142595
25E2F7_22180533_ChIP-Seq_HELA_Human10.0740510
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97088120
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89254762
28FOXP3_21729870_ChIP-Seq_TREG_Human1.87477483
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85370181
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79197619
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77841629
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73416514
33GABP_19822575_ChIP-Seq_HepG2_Human1.72608487
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70808451
35TTF2_22483619_ChIP-Seq_HELA_Human1.65784001
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65677504
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63330050
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60339616
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59546944
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59528635
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58387722
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57890758
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56900085
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47781817
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47162532
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46078196
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45278586
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44140062
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44007233
50ELK1_19687146_ChIP-ChIP_HELA_Human1.40050892
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38711911
52KDM5A_27292631_Chip-Seq_BREAST_Human1.37322282
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.36877840
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35862040
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.31965460
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27562424
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.23331302
58MYC_22102868_ChIP-Seq_BL_Human1.22187470
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21715391
60CIITA_25753668_ChIP-Seq_RAJI_Human1.20916471
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19722179
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17811300
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16760577
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16110535
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15428214
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.14892257
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14816979
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14668430
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13834754
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13346774
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13336372
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12990953
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12882094
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12713599
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.11438691
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10361873
77MYC_18940864_ChIP-ChIP_HL60_Human1.09990603
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07957748
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06825402
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04637079
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03957941
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01174324
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00715830
84* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99985817
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99882832
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.99477611
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.98588480
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97446508
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96990776
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96331438
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.95867402
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93960623
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93418517
94TFEB_21752829_ChIP-Seq_HELA_Human0.92662138
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92658578
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92530477
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.91507510
98CHD1_26751641_Chip-Seq_LNCaP_Human0.88905347
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88779269
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84746068
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84382651
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84144748
103TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83760191
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82979427
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.79022219
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78760757
107VDR_21846776_ChIP-Seq_THP-1_Human0.78552312
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.75847778
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75640463
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75282212
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75229202
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74438374
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74346437
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74194927
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72384497
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71759838
117ZNF263_19887448_ChIP-Seq_K562_Human0.69999756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.61202801
2MP0010094_abnormal_chromosome_stability4.58632323
3MP0004957_abnormal_blastocyst_morpholog3.94563923
4MP0003111_abnormal_nucleus_morphology3.93140152
5MP0003806_abnormal_nucleotide_metabolis3.86033305
6MP0008057_abnormal_DNA_replication3.66842574
7MP0002139_abnormal_hepatobiliary_system3.60545879
8MP0003077_abnormal_cell_cycle3.56980088
9MP0005360_urolithiasis3.52927438
10MP0008058_abnormal_DNA_repair2.84083001
11MP0005085_abnormal_gallbladder_physiolo2.54897861
12MP0008932_abnormal_embryonic_tissue2.47020516
13MP0008007_abnormal_cellular_replicative2.43182089
14MP0006292_abnormal_olfactory_placode2.34058714
15MP0003123_paternal_imprinting2.27486694
16MP0005365_abnormal_bile_salt2.23313111
17MP0001730_embryonic_growth_arrest2.07416524
18MP0002396_abnormal_hematopoietic_system1.96803970
19MP0000350_abnormal_cell_proliferation1.89429031
20MP0003186_abnormal_redox_activity1.87193756
21MP0003136_yellow_coat_color1.86400837
22MP0008875_abnormal_xenobiotic_pharmacok1.84966959
23MP0010352_gastrointestinal_tract_polyps1.84544366
24MP0000566_synostosis1.75048896
25MP0002697_abnormal_eye_size1.73048006
26MP0001346_abnormal_lacrimal_gland1.67932540
27MP0009697_abnormal_copulation1.64687089
28MP0010307_abnormal_tumor_latency1.60663667
29MP0003718_maternal_effect1.59648070
30MP0003937_abnormal_limbs/digits/tail_de1.59557156
31MP0002938_white_spotting1.54141770
32MP0001672_abnormal_embryogenesis/_devel1.48683294
33MP0005380_embryogenesis_phenotype1.48683294
34MP0001286_abnormal_eye_development1.46862939
35MP0001697_abnormal_embryo_size1.45337088
36MP0003252_abnormal_bile_duct1.39594922
37MP0003656_abnormal_erythrocyte_physiolo1.39405710
38MP0003786_premature_aging1.38661348
39MP0008877_abnormal_DNA_methylation1.38304113
40MP0000490_abnormal_crypts_of1.38035203
41MP0002009_preneoplasia1.37941013
42MP0003941_abnormal_skin_development1.37487031
43MP0002080_prenatal_lethality1.35840714
44MP0003984_embryonic_growth_retardation1.33151879
45MP0004185_abnormal_adipocyte_glucose1.31725998
46MP0002088_abnormal_embryonic_growth/wei1.31454783
47MP0002019_abnormal_tumor_incidence1.30624428
48MP0009379_abnormal_foot_pigmentation1.27712593
49MP0003890_abnormal_embryonic-extraembry1.27622413
50MP0009053_abnormal_anal_canal1.26293314
51MP0005332_abnormal_amino_acid1.25659326
52MP0006036_abnormal_mitochondrial_physio1.25163487
53MP0000313_abnormal_cell_death1.21975721
54MP0009840_abnormal_foam_cell1.20983349
55MP0002877_abnormal_melanocyte_morpholog1.19650757
56MP0005076_abnormal_cell_differentiation1.18689294
57MP0002249_abnormal_larynx_morphology1.16125336
58MP0000428_abnormal_craniofacial_morphol1.14887065
59MP0001764_abnormal_homeostasis1.14787924
60MP0002086_abnormal_extraembryonic_tissu1.13863239
61MP0010030_abnormal_orbit_morphology1.13820395
62MP0002085_abnormal_embryonic_tissue1.12401037
63MP0002234_abnormal_pharynx_morphology1.11137002
64MP0004197_abnormal_fetal_growth/weight/1.10179250
65MP0003567_abnormal_fetal_cardiomyocyte1.09568774
66MP0000049_abnormal_middle_ear1.07956136
67MP0003942_abnormal_urinary_system1.06611753
68MP0009672_abnormal_birth_weight1.05474752
69MP0004147_increased_porphyrin_level1.04900431
70MP0005083_abnormal_biliary_tract1.04762594
71MP0010329_abnormal_lipoprotein_level1.03311850
72MP0003861_abnormal_nervous_system1.02599838
73MP0006054_spinal_hemorrhage0.99788128
74MP0004808_abnormal_hematopoietic_stem0.99468449
75MP0005187_abnormal_penis_morphology0.99330291
76MP0000598_abnormal_liver_morphology0.99290818
77MP0002084_abnormal_developmental_patter0.98145165
78MP0009333_abnormal_splenocyte_physiolog0.97464513
79MP0001188_hyperpigmentation0.97141371
80MP0001529_abnormal_vocalization0.97098508
81MP0003705_abnormal_hypodermis_morpholog0.94763124
82MP0001666_abnormal_nutrient_absorption0.94487078
83MP0001293_anophthalmia0.94393782
84MP0000609_abnormal_liver_physiology0.93924311
85MP0005319_abnormal_enzyme/_coenzyme0.91996961
86MP0003938_abnormal_ear_development0.91335371
87MP0001545_abnormal_hematopoietic_system0.90293135
88MP0005397_hematopoietic_system_phenotyp0.90293135
89MP0005266_abnormal_metabolism0.89911390
90MP0002210_abnormal_sex_determination0.88825579
91MP0002160_abnormal_reproductive_system0.88224424
92MP0006035_abnormal_mitochondrial_morpho0.87861350
93MP0002233_abnormal_nose_morphology0.85179152
94MP0005408_hypopigmentation0.82847677
95MP0001145_abnormal_male_reproductive0.82583359
96MP0000689_abnormal_spleen_morphology0.82500401
97MP0003121_genomic_imprinting0.82463272
98MP0003385_abnormal_body_wall0.81190734
99MP0003755_abnormal_palate_morphology0.81064998
100MP0000358_abnormal_cell_content/0.80910908
101MP0003315_abnormal_perineum_morphology0.79269831
102MP0002722_abnormal_immune_system0.78835726
103MP0001119_abnormal_female_reproductive0.78647580
104MP0000653_abnormal_sex_gland0.74747904
105MP0004019_abnormal_vitamin_homeostasis0.74380379
106MP0001853_heart_inflammation0.74059079
107MP0005389_reproductive_system_phenotype0.73708685
108MP0000703_abnormal_thymus_morphology0.72875990
109MP0004233_abnormal_muscle_weight0.72681370
110MP0003935_abnormal_craniofacial_develop0.71804611
111MP0003221_abnormal_cardiomyocyte_apopto0.71070080
112MP0002132_abnormal_respiratory_system0.70729745
113MP0002398_abnormal_bone_marrow0.70389699
114MP0000432_abnormal_head_morphology0.70172932
115MP0003115_abnormal_respiratory_system0.69517407
116MP0000537_abnormal_urethra_morphology0.69061485
117MP0002111_abnormal_tail_morphology0.68641158
118MP0000631_abnormal_neuroendocrine_gland0.67232318
119MP0002081_perinatal_lethality0.67146159
120MP0001915_intracranial_hemorrhage0.66679744
121MP0009250_abnormal_appendicular_skeleto0.66397564
122MP0001929_abnormal_gametogenesis0.66091921
123MP0005451_abnormal_body_composition0.65820759
124MP0003283_abnormal_digestive_organ0.65814897
125MP0002114_abnormal_axial_skeleton0.65410098
126MP0005171_absent_coat_pigmentation0.65377292
127MP0000534_abnormal_ureter_morphology0.65017928
128MP0005391_vision/eye_phenotype0.64840012
129MP0008995_early_reproductive_senescence0.64287147
130MP0002116_abnormal_craniofacial_bone0.64007983
131MP0003763_abnormal_thymus_physiology0.63450681
132MP0002429_abnormal_blood_cell0.62636662
133MP0005623_abnormal_meninges_morphology0.61896507
134MP0009643_abnormal_urine_homeostasis0.61017693
135MP0003119_abnormal_digestive_system0.60046391
136MP0000477_abnormal_intestine_morphology0.59640626
137MP0000762_abnormal_tongue_morphology0.59461510
138MP0009703_decreased_birth_body0.59231524
139MP0001186_pigmentation_phenotype0.58870955
140MP0009763_increased_sensitivity_to0.58609567
141MP0005023_abnormal_wound_healing0.58516111
142MP0001661_extended_life_span0.58342949
143MP0005501_abnormal_skin_physiology0.58134992
144MP0002092_abnormal_eye_morphology0.57265977
145MP0005384_cellular_phenotype0.56177896
146MP0000579_abnormal_nail_morphology0.56071709

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.14883505
2Reticulocytopenia (HP:0001896)4.31449820
3Abnormality of pyrimidine metabolism (HP:0004353)4.27903565
4Oral leukoplakia (HP:0002745)4.00050383
5Hypobetalipoproteinemia (HP:0003563)3.79763285
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.77149712
7Abnormality of cells of the erythroid lineage (HP:0012130)3.76628803
8Breast hypoplasia (HP:0003187)3.74951357
9Abnormal number of erythroid precursors (HP:0012131)3.61225213
10Chromsome breakage (HP:0040012)3.33077648
11Intrahepatic cholestasis (HP:0001406)3.24344296
12Colon cancer (HP:0003003)3.17120531
13Increased nuchal translucency (HP:0010880)3.11993631
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09780583
15Abnormality of chromosome stability (HP:0003220)3.03185162
16Aplastic anemia (HP:0001915)2.98094659
17Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97507853
18* Macrocytic anemia (HP:0001972)2.91761059
19Abnormality of the carotid arteries (HP:0005344)2.90410920
20Ectopic kidney (HP:0000086)2.86122203
21Duplication of thumb phalanx (HP:0009942)2.78555782
22Rhabdomyosarcoma (HP:0002859)2.73845295
23Meckel diverticulum (HP:0002245)2.73681819
24Cortical dysplasia (HP:0002539)2.70948241
25Abnormality of methionine metabolism (HP:0010901)2.69820714
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.69618780
27Patellar aplasia (HP:0006443)2.65954474
28Impulsivity (HP:0100710)2.62920340
29Abnormality of cochlea (HP:0000375)2.62162127
30Abnormality of the ileum (HP:0001549)2.61728557
31Abnormality of the preputium (HP:0100587)2.61228009
32Medulloblastoma (HP:0002885)2.55866537
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54502867
34Microretrognathia (HP:0000308)2.52661188
35Hyperglycinemia (HP:0002154)2.51383516
36Abnormality of reticulocytes (HP:0004312)2.50577674
37Rough bone trabeculation (HP:0100670)2.48851765
38Missing ribs (HP:0000921)2.48438084
39Aplasia/Hypoplasia of the patella (HP:0006498)2.48070400
40Hyperammonemia (HP:0001987)2.46552156
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.46303306
42Selective tooth agenesis (HP:0001592)2.45545555
4311 pairs of ribs (HP:0000878)2.43800106
44Deep venous thrombosis (HP:0002625)2.43340487
45Multiple enchondromatosis (HP:0005701)2.41009769
46Ependymoma (HP:0002888)2.40039342
47Increased serum pyruvate (HP:0003542)2.39326305
48Abnormality of glycolysis (HP:0004366)2.39326305
49Volvulus (HP:0002580)2.36391513
50Absent thumb (HP:0009777)2.35033813
51High anterior hairline (HP:0009890)2.34521448
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.33505589
53* Pallor (HP:0000980)2.32015160
54Nephroblastoma (Wilms tumor) (HP:0002667)2.31009118
55Overlapping toe (HP:0001845)2.30827492
56Abnormality of serum amino acid levels (HP:0003112)2.29681490
57Abnormality of serine family amino acid metabolism (HP:0010894)2.27391463
58Abnormality of glycine metabolism (HP:0010895)2.27391463
59Agnosia (HP:0010524)2.26973656
60Morphological abnormality of the inner ear (HP:0011390)2.26308452
61Premature graying of hair (HP:0002216)2.20508906
62Hyperglycinuria (HP:0003108)2.19796272
63Spastic diplegia (HP:0001264)2.19613795
64Myelodysplasia (HP:0002863)2.17467112
65Short thumb (HP:0009778)2.17008543
66Nausea (HP:0002018)2.16703725
67Microvesicular hepatic steatosis (HP:0001414)2.15317413
68Degeneration of anterior horn cells (HP:0002398)2.14471002
69Abnormality of the anterior horn cell (HP:0006802)2.14471002
70Bone marrow hypocellularity (HP:0005528)2.14448824
71Hypolipoproteinemia (HP:0010981)2.14015400
72Neoplasm of the pancreas (HP:0002894)2.13357386
73Embryonal renal neoplasm (HP:0011794)2.12327078
74Small intestinal stenosis (HP:0012848)2.12299412
75Duodenal stenosis (HP:0100867)2.12299412
76Increased serum lactate (HP:0002151)2.11751750
77Cellular immunodeficiency (HP:0005374)2.10990480
78Cerebral hypomyelination (HP:0006808)2.07129205
79Abnormality of nucleobase metabolism (HP:0010932)2.06597420
80Septo-optic dysplasia (HP:0100842)2.05297735
81Esophageal atresia (HP:0002032)2.04581574
82Duplicated collecting system (HP:0000081)2.04364783
83Cafe-au-lait spot (HP:0000957)2.03012877
84Carpal bone hypoplasia (HP:0001498)2.02970086
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02264847
86Prolonged partial thromboplastin time (HP:0003645)2.01628445
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01590010
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01590010
89Progressive muscle weakness (HP:0003323)2.00727613
90Proximal placement of thumb (HP:0009623)2.00357311
91Hyperbilirubinemia (HP:0002904)1.99677234
92Absent radius (HP:0003974)1.98762312
93Abnormal lung lobation (HP:0002101)1.98655996
94Horseshoe kidney (HP:0000085)1.97889309
95Arteriovenous malformation (HP:0100026)1.97701987
96Delayed CNS myelination (HP:0002188)1.97296629
97Squamous cell carcinoma (HP:0002860)1.96645228
98Poikilocytosis (HP:0004447)1.96086976
99Clubbing of toes (HP:0100760)1.95327489
100* Pancytopenia (HP:0001876)1.94798764
101Choanal atresia (HP:0000453)1.94738225
102Atresia of the external auditory canal (HP:0000413)1.94153387
103Xanthomatosis (HP:0000991)1.92812081
104Abnormal number of incisors (HP:0011064)1.92024361
105* Megaloblastic anemia (HP:0001889)1.90729787
106Secondary amenorrhea (HP:0000869)1.90226058
107Cerebral edema (HP:0002181)1.88253922
108Abnormality of the calcaneus (HP:0008364)1.88101636
109Sloping forehead (HP:0000340)1.87847333
110Tracheoesophageal fistula (HP:0002575)1.86492159
111Increased hepatocellular lipid droplets (HP:0006565)1.85566569
112Partial duplication of thumb phalanx (HP:0009944)1.84322563
113Triphalangeal thumb (HP:0001199)1.84156318
114Deviation of the thumb (HP:0009603)1.83994950
115Hepatic necrosis (HP:0002605)1.82866660
116Abnormal trabecular bone morphology (HP:0100671)1.82741093
117Hypochromic microcytic anemia (HP:0004840)1.82415948
118Abnormality of the duodenum (HP:0002246)1.82227572
119Absent forearm bone (HP:0003953)1.81330518
120Aplasia involving forearm bones (HP:0009822)1.81330518
121Facial cleft (HP:0002006)1.80112244
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79874051
123Dicarboxylic aciduria (HP:0003215)1.79874051
124Partial duplication of the phalanx of hand (HP:0009999)1.79488659
125Neoplasm of striated muscle (HP:0009728)1.79480807
126Calcaneovalgus deformity (HP:0001848)1.78097860
127Abnormality of the labia minora (HP:0012880)1.78028141
128Hepatocellular carcinoma (HP:0001402)1.76723924
129Thrombocytosis (HP:0001894)1.76658798
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75994103
131Abnormality of chromosome segregation (HP:0002916)1.75920970
132Basal cell carcinoma (HP:0002671)1.75610817
133Pseudobulbar signs (HP:0002200)1.74902607
134Lethargy (HP:0001254)1.74388098
135Conjunctival telangiectasia (HP:0000524)1.73730481
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.71593260
137Abnormality of DNA repair (HP:0003254)1.71097958
138Overriding aorta (HP:0002623)1.69788873
139Abnormality of the phalanges of the hallux (HP:0010057)1.69484819
140Bilateral microphthalmos (HP:0007633)1.67601271
141Septate vagina (HP:0001153)1.67053424
142Abnormality of the renal collecting system (HP:0004742)1.66793618
143Homocystinuria (HP:0002156)1.65981315
144Abnormality of homocysteine metabolism (HP:0010919)1.65981315
145Short middle phalanx of the 5th finger (HP:0004220)1.65626937
146Abnormality of the septum pellucidum (HP:0007375)1.62555119
147Lipid accumulation in hepatocytes (HP:0006561)1.62466770
148Absent septum pellucidum (HP:0001331)1.61205841
149Tetralogy of Fallot (HP:0001636)1.61181116
150Abnormality of the parietal bone (HP:0002696)1.60432789
151Embryonal neoplasm (HP:0002898)1.60221580
152Acute necrotizing encephalopathy (HP:0006965)1.60157990
153Broad distal phalanx of finger (HP:0009836)1.59848036
154Neoplasm of the colon (HP:0100273)1.59843808
155Hypoplasia of the pons (HP:0012110)1.59560596
156Acute encephalopathy (HP:0006846)1.59439793
157Maternal diabetes (HP:0009800)1.58647125
158Deformed tarsal bones (HP:0008119)1.57400586
159Rectal fistula (HP:0100590)1.55795200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.10484605
2WEE14.54839565
3BUB14.04321900
4EIF2AK13.99235589
5VRK23.45863331
6NEK22.58658744
7NEK12.56966344
8TAF12.51332897
9ACVR1B2.44013504
10NME22.43903311
11SRPK12.42347552
12TLK12.40301580
13TTK2.29009966
14BRSK22.18334691
15SMG12.10010062
16PNCK2.08985899
17VRK12.07298762
18PLK42.00984301
19STK161.99159406
20PLK11.96911548
21EIF2AK31.92736207
22CDK71.78358942
23AURKB1.74844132
24TESK21.72727524
25BCKDK1.72590493
26MKNK11.72250550
27ATR1.67680944
28RPS6KA41.56588717
29BRSK11.45930311
30TSSK61.43324317
31PASK1.43189986
32DYRK31.42584836
33MAP3K81.42560484
34CDK41.41498108
35SCYL21.39063031
36CHEK21.38065092
37LATS11.35641354
38CCNB11.33311199
39PLK31.33103777
40RPS6KB21.28294616
41PBK1.24041740
42AURKA1.23813616
43STK41.19553417
44TRIB31.14407469
45CHEK11.12082804
46LATS21.11165122
47STK101.08357033
48MKNK21.06482415
49TGFBR11.05002675
50CDK81.02922619
51FLT30.96564392
52ZAK0.93867111
53KDR0.93022546
54ICK0.90549679
55MAP3K100.88496577
56PIM10.85681107
57PAK40.85586676
58ATM0.83027451
59NEK90.81687507
60CDK60.81476171
61CDK20.79077893
62CSNK2A10.77626377
63CSNK2A20.74907414
64CDK120.73803148
65LRRK20.72891443
66MELK0.72380285
67EIF2AK20.71925571
68MAP2K30.69865652
69PKN20.68851232
70ABL20.68375689
71CAMK1G0.68371127
72CDK30.67810916
73NUAK10.65827265
74MAP3K110.63864345
75PIM20.63506688
76MAPK110.59914930
77CDK10.58950465
78GRK60.58819119
79CDK11A0.56119385
80CDK150.54283654
81CAMK1D0.53910990
82CLK10.52911935
83MAP4K10.51305585
84BRAF0.50432923
85CDK180.49225916
86RPS6KA50.49151112
87PAK10.48559839
88STK30.47554344
89EEF2K0.45292434
90MAPKAPK50.44303808
91STK38L0.43308428
92CDK140.43270254
93MTOR0.41740901
94EPHA20.41725857
95TYK20.39168178
96IRAK30.38753684
97BTK0.38505213
98MAPK140.38399530
99TYRO30.38228262
100FGFR10.35841528
101CSF1R0.34909926
102TAOK20.34158386
103CSNK1E0.33749705
104CSNK1G30.32039781
105AKT10.31491780
106ERBB40.31231345
107TNIK0.29781289
108AKT20.29646579
109GSK3B0.29553747
110PRKCI0.28477730
111CDK90.28119776
112BRD40.26977791
113PRKDC0.26838385
114TEC0.25907142
115ALK0.25168139
116PAK20.25134379
117KSR20.24738173
118TESK10.24415381
119YES10.22770376
120STK240.22645810
121CSNK1G10.21901646
122NME10.21330002
123WNK40.21129883
124DMPK0.20975926
125MAP3K30.20969604
126CSNK1D0.20354842
127ILK0.20170361
128DYRK1B0.18975366
129EPHB20.18899471
130MAP3K90.18406513
131LYN0.18069374
132DYRK20.17060056
133ERBB20.15979632

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02271156
2Mismatch repair_Homo sapiens_hsa034304.14081152
3Ribosome_Homo sapiens_hsa030102.85322780
4* One carbon pool by folate_Homo sapiens_hsa006702.78330602
5Homologous recombination_Homo sapiens_hsa034402.70829298
6Base excision repair_Homo sapiens_hsa034102.65267474
7Proteasome_Homo sapiens_hsa030502.57362992
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55350062
9Nucleotide excision repair_Homo sapiens_hsa034202.50800313
10Spliceosome_Homo sapiens_hsa030402.44558278
11Pyrimidine metabolism_Homo sapiens_hsa002402.30678627
12RNA polymerase_Homo sapiens_hsa030202.24880257
13RNA transport_Homo sapiens_hsa030132.16960196
14Cell cycle_Homo sapiens_hsa041102.14958580
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86935307
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83506428
17Fanconi anemia pathway_Homo sapiens_hsa034601.74241873
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.70135437
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.69028951
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67923105
21Non-homologous end-joining_Homo sapiens_hsa034501.64096863
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59691717
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57659866
24Selenocompound metabolism_Homo sapiens_hsa004501.56150233
25Biosynthesis of amino acids_Homo sapiens_hsa012301.43018015
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.42487144
27Oxidative phosphorylation_Homo sapiens_hsa001901.30286792
28RNA degradation_Homo sapiens_hsa030181.28103454
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26238274
30Systemic lupus erythematosus_Homo sapiens_hsa053221.23601134
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14871425
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14203310
33p53 signaling pathway_Homo sapiens_hsa041151.14034938
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13094153
35Carbon metabolism_Homo sapiens_hsa012001.11898795
36Basal transcription factors_Homo sapiens_hsa030221.11516318
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10342843
38Sulfur relay system_Homo sapiens_hsa041221.10088906
39Pentose phosphate pathway_Homo sapiens_hsa000301.05934350
40Tryptophan metabolism_Homo sapiens_hsa003801.05843876
41Glutathione metabolism_Homo sapiens_hsa004801.05649232
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04922747
43Purine metabolism_Homo sapiens_hsa002301.04230831
44Arginine biosynthesis_Homo sapiens_hsa002200.99515178
45Fatty acid degradation_Homo sapiens_hsa000710.98417740
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97645490
47Basal cell carcinoma_Homo sapiens_hsa052170.95746292
48mRNA surveillance pathway_Homo sapiens_hsa030150.92874816
49* Folate biosynthesis_Homo sapiens_hsa007900.91324449
50Peroxisome_Homo sapiens_hsa041460.89974515
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87385065
52Pyruvate metabolism_Homo sapiens_hsa006200.83827464
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83824625
54Vitamin B6 metabolism_Homo sapiens_hsa007500.83543144
55Nitrogen metabolism_Homo sapiens_hsa009100.83500030
56Propanoate metabolism_Homo sapiens_hsa006400.79755371
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77664996
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77378447
59Complement and coagulation cascades_Homo sapiens_hsa046100.74581874
60Chemical carcinogenesis_Homo sapiens_hsa052040.74458936
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73140645
62Arginine and proline metabolism_Homo sapiens_hsa003300.72909822
63Alzheimers disease_Homo sapiens_hsa050100.72820720
64beta-Alanine metabolism_Homo sapiens_hsa004100.71286627
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67856774
66MicroRNAs in cancer_Homo sapiens_hsa052060.67422525
67Retinol metabolism_Homo sapiens_hsa008300.66431856
68Hedgehog signaling pathway_Homo sapiens_hsa043400.66403920
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65510298
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65244129
71Butanoate metabolism_Homo sapiens_hsa006500.64757465
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.64541033
73Phenylalanine metabolism_Homo sapiens_hsa003600.63372395
74Histidine metabolism_Homo sapiens_hsa003400.63308074
75Caffeine metabolism_Homo sapiens_hsa002320.62487931
76Tyrosine metabolism_Homo sapiens_hsa003500.59423744
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59205164
78Epstein-Barr virus infection_Homo sapiens_hsa051690.56887748
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55845170
80Hippo signaling pathway_Homo sapiens_hsa043900.55836143
81Fatty acid metabolism_Homo sapiens_hsa012120.52933665
82Viral carcinogenesis_Homo sapiens_hsa052030.52664948
83* Metabolic pathways_Homo sapiens_hsa011000.51720281
84Lysine degradation_Homo sapiens_hsa003100.50222662
85Protein export_Homo sapiens_hsa030600.49147048
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48491844
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48393127
88Herpes simplex infection_Homo sapiens_hsa051680.48181462
89Wnt signaling pathway_Homo sapiens_hsa043100.46267397
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46154804
91Chronic myeloid leukemia_Homo sapiens_hsa052200.45967915
92Prostate cancer_Homo sapiens_hsa052150.45085984
93N-Glycan biosynthesis_Homo sapiens_hsa005100.44265730
94Cardiac muscle contraction_Homo sapiens_hsa042600.43531261
95Fat digestion and absorption_Homo sapiens_hsa049750.42308344
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41760162
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.41323803
98Vitamin digestion and absorption_Homo sapiens_hsa049770.39735082
99Alcoholism_Homo sapiens_hsa050340.39339028
100Fatty acid elongation_Homo sapiens_hsa000620.38674276
101Colorectal cancer_Homo sapiens_hsa052100.38588356
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35763367
103Melanoma_Homo sapiens_hsa052180.35714207
104Adherens junction_Homo sapiens_hsa045200.35429582
105Steroid biosynthesis_Homo sapiens_hsa001000.35233369
106Parkinsons disease_Homo sapiens_hsa050120.34750886
107TGF-beta signaling pathway_Homo sapiens_hsa043500.34255889
108Huntingtons disease_Homo sapiens_hsa050160.33835218
109Antigen processing and presentation_Homo sapiens_hsa046120.33744956
110Pancreatic cancer_Homo sapiens_hsa052120.33729016
111Oocyte meiosis_Homo sapiens_hsa041140.31928296
112Starch and sucrose metabolism_Homo sapiens_hsa005000.31025670
113Non-small cell lung cancer_Homo sapiens_hsa052230.29841916
114PPAR signaling pathway_Homo sapiens_hsa033200.29368957
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27664171
116Fructose and mannose metabolism_Homo sapiens_hsa000510.27185643
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25574854
118HTLV-I infection_Homo sapiens_hsa051660.25027090
119Staphylococcus aureus infection_Homo sapiens_hsa051500.24507150
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23607837
121Galactose metabolism_Homo sapiens_hsa000520.23382171
122Thyroid cancer_Homo sapiens_hsa052160.22730927
123Small cell lung cancer_Homo sapiens_hsa052220.20605362
124Bladder cancer_Homo sapiens_hsa052190.16993511
125Notch signaling pathway_Homo sapiens_hsa043300.16939351
126Pathways in cancer_Homo sapiens_hsa052000.15871929
127Glioma_Homo sapiens_hsa052140.10993695
128Endometrial cancer_Homo sapiens_hsa052130.08228959

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »