ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.47477557
2	nucleotide transmembrane transport (GO:1901679)	4.01230107
3	response to pheromone (GO:0019236)	3.98373179
4	behavioral response to nicotine (GO:0035095)	3.93672142
5	fucose catabolic process (GO:0019317)	3.85537868
6	L-fucose metabolic process (GO:0042354)	3.85537868
7	L-fucose catabolic process (GO:0042355)	3.85537868
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.62480756
9	organic cation transport (GO:0015695)	3.57378189
10	regulation of cilium movement (GO:0003352)	3.46265260
11	nonmotile primary cilium assembly (GO:0035058)	3.46147093
12	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.46068299
13	platelet dense granule organization (GO:0060155)	3.31012999
14	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.29906409
15	cytidine metabolic process (GO:0046087)	3.25171798
16	cytidine catabolic process (GO:0006216)	3.25171798
17	cytidine deamination (GO:0009972)	3.25171798
18	cellular ketone body metabolic process (GO:0046950)	3.24179131
19	indolalkylamine catabolic process (GO:0046218)	3.24153103
20	tryptophan catabolic process (GO:0006569)	3.24153103
21	indole-containing compound catabolic process (GO:0042436)	3.24153103
22	adaptation of signaling pathway (GO:0023058)	3.21578921
23	epithelial cilium movement (GO:0003351)	3.21271650
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.17967916
25	nucleoside transmembrane transport (GO:1901642)	3.16794281
26	protein localization to cilium (GO:0061512)	3.12925970
27	detection of light stimulus involved in visual perception (GO:0050908)	3.11329408
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.11329408
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.10559961
30	negative regulation of telomere maintenance (GO:0032205)	3.06930021
31	regulation of isotype switching to IgG isotypes (GO:0048302)	3.05168758
32	ketone body metabolic process (GO:1902224)	3.00092557
33	indolalkylamine metabolic process (GO:0006586)	3.00015061
34	axoneme assembly (GO:0035082)	2.99378884
35	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.98675464
36	piRNA metabolic process (GO:0034587)	2.98045983
37	glycerophospholipid catabolic process (GO:0046475)	2.97036356
38	cilium morphogenesis (GO:0060271)	2.96583934
39	kynurenine metabolic process (GO:0070189)	2.94237764
40	protein K11-linked deubiquitination (GO:0035871)	2.93711787
41	cellular response to ATP (GO:0071318)	2.91497147
42	tryptophan metabolic process (GO:0006568)	2.84570360
43	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.84405719
44	neuronal action potential (GO:0019228)	2.83595504
45	negative regulation of mast cell activation (GO:0033004)	2.83149104
46	protein complex biogenesis (GO:0070271)	2.83022902
47	sulfation (GO:0051923)	2.82137441
48	positive regulation of fatty acid transport (GO:2000193)	2.81007858
49	L-methionine salvage (GO:0071267)	2.80044541
50	L-methionine biosynthetic process (GO:0071265)	2.80044541
51	amino acid salvage (GO:0043102)	2.80044541
52	heme transport (GO:0015886)	2.78484381
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76944222
54	retinal cone cell development (GO:0046549)	2.74996332
55	cilium organization (GO:0044782)	2.74713940
56	positive regulation of T-helper 1 type immune response (GO:0002827)	2.73605236
57	regulation of glucokinase activity (GO:0033131)	2.72701149
58	regulation of hexokinase activity (GO:1903299)	2.72701149
59	behavioral response to ethanol (GO:0048149)	2.72510740
60	protein polyglutamylation (GO:0018095)	2.70682777
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.69958194
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.69958194
63	NADH dehydrogenase complex assembly (GO:0010257)	2.69958194
64	respiratory chain complex IV assembly (GO:0008535)	2.67410449
65	positive regulation of defense response to virus by host (GO:0002230)	2.66643535
66	gamma-aminobutyric acid transport (GO:0015812)	2.66483579
67	positive regulation of glycolytic process (GO:0045821)	2.65821037
68	protein neddylation (GO:0045116)	2.65254743
69	cilium assembly (GO:0042384)	2.62506671
70	photoreceptor cell maintenance (GO:0045494)	2.62126360
71	multicellular organism reproduction (GO:0032504)	2.59056181
72	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.58183196
73	exogenous drug catabolic process (GO:0042738)	2.57000823
74	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.56692439
75	positive regulation of prostaglandin secretion (GO:0032308)	2.56053447
76	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55634013
77	cornea development in camera-type eye (GO:0061303)	2.55218282
78	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.54276442
79	protein-cofactor linkage (GO:0018065)	2.53399801
80	dopamine transport (GO:0015872)	2.52035549
81	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.50725847
82	S-adenosylmethionine metabolic process (GO:0046500)	2.50681721
83	regulation of neurotransmitter uptake (GO:0051580)	2.50435510
84	cilium movement (GO:0003341)	2.49565483
85	photoreceptor cell development (GO:0042461)	2.48556152
86	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.48428660
87	reflex (GO:0060004)	2.46846573
88	iron coordination entity transport (GO:1901678)	2.45976185
89	neural tube formation (GO:0001841)	2.45388801
90	regulation of action potential (GO:0098900)	2.44782921
91	inositol phosphate catabolic process (GO:0071545)	2.44127015
92	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.44006616
93	signal peptide processing (GO:0006465)	2.43879002
94	synapsis (GO:0007129)	2.40213217
95	GPI anchor metabolic process (GO:0006505)	2.39368985
96	brain morphogenesis (GO:0048854)	2.38571300
97	cytochrome complex assembly (GO:0017004)	2.38454570
98	positive regulation of icosanoid secretion (GO:0032305)	2.37149804
99	proline transport (GO:0015824)	2.36444222
100	startle response (GO:0001964)	2.36365504

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.52704303
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.94896939
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.73084849
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.71644321
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66809924
6	VDR_22108803_ChIP-Seq_LS180_Human	2.65482111
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.58306844
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51327274
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48207059
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37077454
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25034176
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07555579
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01234879
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.00846522
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00564699
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99920232
17	EWS_26573619_Chip-Seq_HEK293_Human	1.99248038
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97484649
19	P300_19829295_ChIP-Seq_ESCs_Human	1.94759825
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90269485
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.87375245
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87232734
23	FUS_26573619_Chip-Seq_HEK293_Human	1.85523673
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67402208
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66002464
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.65546131
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60792242
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.59974991
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59839266
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58040940
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.56446252
32	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52524062
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52365287
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51753400
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51753400
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49743260
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49378211
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49368775
39	STAT3_23295773_ChIP-Seq_U87_Human	1.48613766
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47539323
41	TCF4_23295773_ChIP-Seq_U87_Human	1.45465364
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44385502
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44228795
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39801259
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36923031
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.36415496
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36029652
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35259464
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34786280
50	AR_25329375_ChIP-Seq_VCAP_Human	1.34192643
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33987231
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33987231
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32938460
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32036944
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32036944
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31345984
57	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27357015
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27185740
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26670364
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26366182
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25075830
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24325893
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24023133
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22886081
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21539553
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19599441
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18897645
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17814399
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17540613
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17470555
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17416349
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17149698
73	AR_20517297_ChIP-Seq_VCAP_Human	1.15242874
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15059436
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14707603
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13861100
77	NCOR_22424771_ChIP-Seq_293T_Human	1.13687138
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12306216
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.11666148
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11620234
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11301987
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10842444
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.10660412
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09962830
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09822647
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.08888904
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08500141
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07884166
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05972348
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04405506
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04266465
92	GATA3_26560356_Chip-Seq_TH2_Human	1.03715753
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03608119
94	MYC_18940864_ChIP-ChIP_HL60_Human	1.03357681
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02666415
96	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.02051625
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01621384
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00524296
99	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00439311
100	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00439311

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.23826338
2	MP0008877_abnormal_DNA_methylation	2.83641079
3	MP0005645_abnormal_hypothalamus_physiol	2.58389795
4	MP0001968_abnormal_touch/_nociception	2.54125419
5	MP0000569_abnormal_digit_pigmentation	2.48658502
6	MP0005551_abnormal_eye_electrophysiolog	2.42505232
7	MP0005646_abnormal_pituitary_gland	2.34990162
8	MP0002102_abnormal_ear_morphology	2.18935580
9	MP0002876_abnormal_thyroid_physiology	2.12773437
10	MP0003787_abnormal_imprinting	2.11382901
11	MP0001984_abnormal_olfaction	2.05249602
12	MP0001986_abnormal_taste_sensitivity	2.00052175
13	MP0002837_dystrophic_cardiac_calcinosis	1.89951577
14	MP0008872_abnormal_physiological_respon	1.89450057
15	MP0008875_abnormal_xenobiotic_pharmacok	1.89025759
16	MP0003880_abnormal_central_pattern	1.87662820
17	MP0003011_delayed_dark_adaptation	1.87382103
18	MP0008789_abnormal_olfactory_epithelium	1.84974998
19	MP0005253_abnormal_eye_physiology	1.82827008
20	MP0006072_abnormal_retinal_apoptosis	1.76971040
21	MP0004147_increased_porphyrin_level	1.76676537
22	MP0009745_abnormal_behavioral_response	1.73608261
23	MP0002736_abnormal_nociception_after	1.69635077
24	MP0009046_muscle_twitch	1.65728301
25	MP0004142_abnormal_muscle_tone	1.64102959
26	MP0002272_abnormal_nervous_system	1.63902940
27	MP0001501_abnormal_sleep_pattern	1.63471675
28	MP0002653_abnormal_ependyma_morphology	1.62313201
29	MP0006292_abnormal_olfactory_placode	1.61543186
30	MP0005394_taste/olfaction_phenotype	1.59375907
31	MP0005499_abnormal_olfactory_system	1.59375907
32	MP0002638_abnormal_pupillary_reflex	1.56308735
33	MP0004885_abnormal_endolymph	1.52118790
34	MP0000427_abnormal_hair_cycle	1.50367013
35	MP0001529_abnormal_vocalization	1.38798211
36	MP0002735_abnormal_chemical_nociception	1.37953354
37	MP0004043_abnormal_pH_regulation	1.37568303
38	MP0005671_abnormal_response_to	1.36048053
39	MP0005085_abnormal_gallbladder_physiolo	1.33921953
40	MP0001486_abnormal_startle_reflex	1.33771979
41	MP0004782_abnormal_surfactant_physiolog	1.27558837
42	MP0002909_abnormal_adrenal_gland	1.25610818
43	MP0002733_abnormal_thermal_nociception	1.22914607
44	MP0000631_abnormal_neuroendocrine_gland	1.22729873
45	MP0002693_abnormal_pancreas_physiology	1.22627984
46	MP0002557_abnormal_social/conspecific_i	1.19713789
47	MP0000372_irregular_coat_pigmentation	1.19195720
48	MP0010386_abnormal_urinary_bladder	1.18527602
49	MP0006276_abnormal_autonomic_nervous	1.18298787
50	MP0002064_seizures	1.17528976
51	MP0005075_abnormal_melanosome_morpholog	1.17220849
52	MP0004133_heterotaxia	1.16699862
53	MP0005084_abnormal_gallbladder_morpholo	1.16318284
54	MP0005174_abnormal_tail_pigmentation	1.15728998
55	MP0005332_abnormal_amino_acid	1.14660353
56	MP0004742_abnormal_vestibular_system	1.14502221
57	MP0002572_abnormal_emotion/affect_behav	1.14435930
58	MP0001440_abnormal_grooming_behavior	1.14107856
59	MP0002938_white_spotting	1.12565355
60	MP0001485_abnormal_pinna_reflex	1.10878865
61	MP0005386_behavior/neurological_phenoty	1.10488334
62	MP0004924_abnormal_behavior	1.10488334
63	MP0001970_abnormal_pain_threshold	1.09813917
64	MP0005389_reproductive_system_phenotype	1.09399941
65	MP0001764_abnormal_homeostasis	1.07669928
66	MP0003252_abnormal_bile_duct	1.02129436
67	MP0002234_abnormal_pharynx_morphology	0.99698545
68	MP0001873_stomach_inflammation	0.98372866
69	MP0005365_abnormal_bile_salt	0.95545232
70	MP0003283_abnormal_digestive_organ	0.94701204
71	MP0001905_abnormal_dopamine_level	0.93915383
72	MP0002163_abnormal_gland_morphology	0.92608434
73	MP0001944_abnormal_pancreas_morphology	0.91425931
74	MP0002751_abnormal_autonomic_nervous	0.90738256
75	MP0003646_muscle_fatigue	0.90355716
76	MP0002063_abnormal_learning/memory/cond	0.90300462
77	MP0009764_decreased_sensitivity_to	0.89984114
78	MP0005379_endocrine/exocrine_gland_phen	0.89453228
79	MP0003635_abnormal_synaptic_transmissio	0.89260989
80	MP0002332_abnormal_exercise_endurance	0.87648348
81	MP0002277_abnormal_respiratory_mucosa	0.87409027
82	MP0002095_abnormal_skin_pigmentation	0.87391525
83	MP0005195_abnormal_posterior_eye	0.87301206
84	MP0002067_abnormal_sensory_capabilities	0.85103938
85	MP0003718_maternal_effect	0.84776662
86	MP0002160_abnormal_reproductive_system	0.84311652
87	MP0001502_abnormal_circadian_rhythm	0.83763887
88	MP0001919_abnormal_reproductive_system	0.83359249
89	MP0002229_neurodegeneration	0.82466297
90	MP0010329_abnormal_lipoprotein_level	0.82142036
91	MP0003633_abnormal_nervous_system	0.82093604
92	MP0008058_abnormal_DNA_repair	0.79112363
93	MP0002734_abnormal_mechanical_nocicepti	0.78730009
94	MP0002928_abnormal_bile_duct	0.78303188
95	MP0001756_abnormal_urination	0.78096285
96	MP0003136_yellow_coat_color	0.76060966
97	MP0002752_abnormal_somatic_nervous	0.75937719
98	MP0005423_abnormal_somatic_nervous	0.75765777
99	MP0005360_urolithiasis	0.75583222
100	MP0005410_abnormal_fertilization	0.72372222

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.29135571
2	Abnormality of midbrain morphology (HP:0002418)	4.29135571
3	Pancreatic cysts (HP:0001737)	3.86491632
4	Pancreatic fibrosis (HP:0100732)	3.78547352
5	True hermaphroditism (HP:0010459)	3.62128503
6	Nephronophthisis (HP:0000090)	3.52296708
7	Medial flaring of the eyebrow (HP:0010747)	3.47534167
8	Abnormality of the renal cortex (HP:0011035)	3.42315900
9	Renal cortical cysts (HP:0000803)	3.39492862
10	Congenital stationary night blindness (HP:0007642)	3.38274781
11	Abolished electroretinogram (ERG) (HP:0000550)	3.37138524
12	Attenuation of retinal blood vessels (HP:0007843)	3.12831824
13	Chronic hepatic failure (HP:0100626)	3.08232330
14	Abnormality of the renal medulla (HP:0100957)	2.97334050
15	Hyperventilation (HP:0002883)	2.92735857
16	Gait imbalance (HP:0002141)	2.87348680
17	Pendular nystagmus (HP:0012043)	2.84232862
18	Congenital primary aphakia (HP:0007707)	2.82548338
19	Hypothermia (HP:0002045)	2.76306428
20	Polydipsia (HP:0001959)	2.70976667
21	Abnormal drinking behavior (HP:0030082)	2.70976667
22	Large for gestational age (HP:0001520)	2.69229717
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.66041687
24	Keratoconus (HP:0000563)	2.54270061
25	Increased corneal curvature (HP:0100692)	2.54270061
26	Methylmalonic acidemia (HP:0002912)	2.54176637
27	Tubular atrophy (HP:0000092)	2.53320991
28	Nephrogenic diabetes insipidus (HP:0009806)	2.52713706
29	Stomach cancer (HP:0012126)	2.47275397
30	Cystic liver disease (HP:0006706)	2.46120655
31	Gaze-evoked nystagmus (HP:0000640)	2.45513953
32	Hypomagnesemia (HP:0002917)	2.34595304
33	Bony spicule pigmentary retinopathy (HP:0007737)	2.32658958
34	Inability to walk (HP:0002540)	2.29778867
35	Thyroiditis (HP:0100646)	2.27211290
36	Progressive macrocephaly (HP:0004481)	2.26945389
37	Genital tract atresia (HP:0001827)	2.25086785
38	Acute necrotizing encephalopathy (HP:0006965)	2.23673471
39	Abnormality of the labia minora (HP:0012880)	2.22352197
40	Methylmalonic aciduria (HP:0012120)	2.21822349
41	Progressive inability to walk (HP:0002505)	2.21407069
42	3-Methylglutaconic aciduria (HP:0003535)	2.20213023
43	Chorioretinal atrophy (HP:0000533)	2.19972378
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19031961
45	Absent/shortened dynein arms (HP:0200106)	2.19031961
46	Congenital hepatic fibrosis (HP:0002612)	2.18185150
47	Mitochondrial inheritance (HP:0001427)	2.17689286
48	Decreased central vision (HP:0007663)	2.16858141
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16342603
50	Congenital sensorineural hearing impairment (HP:0008527)	2.13942176
51	Colon cancer (HP:0003003)	2.11580125
52	Vaginal atresia (HP:0000148)	2.11298160
53	Acute encephalopathy (HP:0006846)	2.05484591
54	Polyuria (HP:0000103)	2.05117941
55	Type II lissencephaly (HP:0007260)	2.04661412
56	Abnormality of macular pigmentation (HP:0008002)	2.04304454
57	Sclerocornea (HP:0000647)	2.04133370
58	Increased CSF lactate (HP:0002490)	2.02598814
59	Hemiparesis (HP:0001269)	2.02396682
60	Stomatitis (HP:0010280)	2.02391318
61	Furrowed tongue (HP:0000221)	2.00147740
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99095484
63	Optic disc pallor (HP:0000543)	1.99009330
64	Progressive cerebellar ataxia (HP:0002073)	1.96755262
65	Postaxial hand polydactyly (HP:0001162)	1.96732072
66	Hypoalbuminemia (HP:0003073)	1.96121944
67	Abnormal albumin level (HP:0012116)	1.96121944
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.94788289
69	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94788289
70	Intestinal atresia (HP:0011100)	1.92790435
71	Anencephaly (HP:0002323)	1.92130411
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.89833426
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.89833426
74	Broad-based gait (HP:0002136)	1.87764024
75	Postaxial foot polydactyly (HP:0001830)	1.85418692
76	Tachypnea (HP:0002789)	1.85309897
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.83160747
78	Poor coordination (HP:0002370)	1.82139248
79	Adactyly (HP:0009776)	1.81215398
80	Retinitis pigmentosa (HP:0000510)	1.81204565
81	Hepatic necrosis (HP:0002605)	1.80774509
82	Male pseudohermaphroditism (HP:0000037)	1.80735483
83	IgG deficiency (HP:0004315)	1.79914858
84	Focal motor seizures (HP:0011153)	1.78802185
85	Ketoacidosis (HP:0001993)	1.78530623
86	Bile duct proliferation (HP:0001408)	1.78367143
87	Abnormal biliary tract physiology (HP:0012439)	1.78367143
88	Absent speech (HP:0001344)	1.78303435
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76889935
90	Congenital, generalized hypertrichosis (HP:0004540)	1.76768467
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.76070499
92	Oligodactyly (hands) (HP:0001180)	1.74842800
93	Short tibia (HP:0005736)	1.73775704
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73367923
95	Febrile seizures (HP:0002373)	1.71945619
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.70014261
97	Hypoplasia of the fovea (HP:0007750)	1.70014261
98	Abnormality of eosinophils (HP:0001879)	1.67026801
99	Abnormality of vitamin B metabolism (HP:0004340)	1.66835026
100	Polyphagia (HP:0002591)	1.65886148

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.43069807
2	ADRBK2	3.62407585
3	MAP4K2	2.79131963
4	TXK	2.71997726
5	NUAK1	2.61530887
6	TLK1	2.49261084
7	BMPR1B	2.47506120
8	GRK1	2.31805216
9	WNK3	2.26187924
10	WNK4	1.98967951
11	CASK	1.94689458
12	ACVR1B	1.93007779
13	STK39	1.92386407
14	PINK1	1.70680746
15	INSRR	1.65394417
16	MAPK13	1.63621025
17	MAP3K4	1.60546302
18	DAPK2	1.59669342
19	FGFR2	1.54075168
20	TAOK3	1.53319621
21	ZAK	1.49463676
22	PAK3	1.48899186
23	TNIK	1.35641576
24	OXSR1	1.35478758
25	VRK2	1.28031329
26	NLK	1.25398494
27	CSNK1G2	1.17614144
28	CSNK1G3	1.16331447
29	EPHA3	1.16009743
30	VRK1	1.14531537
31	PRKCE	1.14494302
32	CSNK1G1	1.14316463
33	PLK2	1.13854344
34	ERBB3	1.05800226
35	TNK2	1.05611522
36	NTRK3	1.05609633
37	MAP2K6	1.03267158
38	EIF2AK3	1.02565919
39	ADRBK1	1.02312399
40	KIT	0.97393054
41	PRKCG	0.95222700
42	CSNK1A1L	0.94432988
43	MAP2K7	0.93231779
44	TRIM28	0.92546186
45	DYRK2	0.91491426
46	BCKDK	0.90285230
47	MST4	0.90143435
48	TAF1	0.89031023
49	GRK7	0.85995915
50	EPHA4	0.84113034
51	IKBKB	0.80055329
52	GRK5	0.77996130
53	PIK3CA	0.77547470
54	IRAK1	0.77315262
55	CAMKK2	0.71487335
56	STK38L	0.70357752
57	PHKG1	0.69492570
58	PHKG2	0.69492570
59	TEC	0.69016463
60	STK11	0.66608738
61	NTRK2	0.65413931
62	MAPK15	0.63981184
63	MARK1	0.63572268
64	MAP2K2	0.62629598
65	CAMK2A	0.62029204
66	FER	0.61630328
67	BCR	0.59495217
68	SGK2	0.58113078
69	PLK3	0.56782416
70	IKBKE	0.56026508
71	STK3	0.55159018
72	EIF2AK2	0.54733557
73	ITK	0.53896501
74	PRKCQ	0.53145701
75	DYRK3	0.53145022
76	MKNK2	0.51630108
77	MAPKAPK3	0.49791931
78	BMPR2	0.49762968
79	RPS6KA5	0.49427786
80	SYK	0.46168667
81	CSNK1D	0.45904109
82	PRKACA	0.45779893
83	CSNK1A1	0.45614971
84	DAPK1	0.44992701
85	TIE1	0.43146929
86	PTK2B	0.42355317
87	TSSK6	0.41349228
88	SGK223	0.41168470
89	SGK494	0.41168470
90	MUSK	0.40327634
91	PNCK	0.39257703
92	PKN1	0.36808696
93	DYRK1A	0.36510650
94	PRKCZ	0.36186591
95	MAPKAPK5	0.36140290
96	FLT3	0.35637306
97	TGFBR1	0.35095589
98	CHUK	0.35000100
99	ABL1	0.34875349
100	AKT3	0.34577803

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.75644898
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.72569971
3	Phototransduction_Homo sapiens_hsa04744	2.67254767
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52321391
5	Caffeine metabolism_Homo sapiens_hsa00232	2.47552982
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.45892251
7	Protein export_Homo sapiens_hsa03060	2.45816369
8	Butanoate metabolism_Homo sapiens_hsa00650	2.44093263
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.41170774
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38969716
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37343654
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26125415
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25793831
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.23149048
15	Ether lipid metabolism_Homo sapiens_hsa00565	2.09643571
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99140268
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85013010
18	Propanoate metabolism_Homo sapiens_hsa00640	1.68923114
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64375999
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63173959
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.62522616
22	Nicotine addiction_Homo sapiens_hsa05033	1.58400901
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.57606924
24	Peroxisome_Homo sapiens_hsa04146	1.48039999
25	Basal transcription factors_Homo sapiens_hsa03022	1.44756288
26	Regulation of autophagy_Homo sapiens_hsa04140	1.44721233
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.41262467
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39613989
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37150220
30	RNA polymerase_Homo sapiens_hsa03020	1.31858370
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26757829
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24419069
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23930596
34	Insulin secretion_Homo sapiens_hsa04911	1.23469801
35	Parkinsons disease_Homo sapiens_hsa05012	1.22757735
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22576694
37	Retinol metabolism_Homo sapiens_hsa00830	1.20033053
38	Taste transduction_Homo sapiens_hsa04742	1.14185407
39	Homologous recombination_Homo sapiens_hsa03440	1.10291909
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.09593817
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07680711
42	Morphine addiction_Homo sapiens_hsa05032	1.06901298
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03656593
44	GABAergic synapse_Homo sapiens_hsa04727	0.98116573
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92641280
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90514492
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90168734
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89505934
49	Non-homologous end-joining_Homo sapiens_hsa03450	0.89225687
50	RNA degradation_Homo sapiens_hsa03018	0.88333204
51	Mineral absorption_Homo sapiens_hsa04978	0.87411415
52	ABC transporters_Homo sapiens_hsa02010	0.86197089
53	Olfactory transduction_Homo sapiens_hsa04740	0.85032525
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82652280
55	Fatty acid elongation_Homo sapiens_hsa00062	0.81178685
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79554697
57	Sulfur metabolism_Homo sapiens_hsa00920	0.78838766
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78134869
59	Circadian entrainment_Homo sapiens_hsa04713	0.78003607
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77190532
61	Circadian rhythm_Homo sapiens_hsa04710	0.75358524
62	Serotonergic synapse_Homo sapiens_hsa04726	0.74801612
63	Sulfur relay system_Homo sapiens_hsa04122	0.74351188
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.72526673
65	Huntingtons disease_Homo sapiens_hsa05016	0.72316232
66	Proteasome_Homo sapiens_hsa03050	0.71056756
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70403442
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69460698
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.68327050
70	Alzheimers disease_Homo sapiens_hsa05010	0.67487355
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66661943
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66399700
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65364262
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64042468
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.62849068
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61295128
77	Allograft rejection_Homo sapiens_hsa05330	0.59650645
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59257921
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57996076
80	Salivary secretion_Homo sapiens_hsa04970	0.57328901
81	* Metabolic pathways_Homo sapiens_hsa01100	0.54854139
82	Fatty acid degradation_Homo sapiens_hsa00071	0.52306117
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.52114195
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51897351
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51849076
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.51789671
87	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51236033
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.50875657
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49480395
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48882383
91	Cocaine addiction_Homo sapiens_hsa05030	0.46358049
92	Amphetamine addiction_Homo sapiens_hsa05031	0.43774370
93	Asthma_Homo sapiens_hsa05310	0.43643484
94	Renin secretion_Homo sapiens_hsa04924	0.41992539
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.40448596
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38692851
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38334184
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37674499
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37190050
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.34811340

DHFRL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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