DHFRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)6.41629608
2DNA strand elongation involved in DNA replication (GO:0006271)6.39245366
3DNA strand elongation (GO:0022616)6.13944509
4CENP-A containing nucleosome assembly (GO:0034080)6.02084636
5chromatin remodeling at centromere (GO:0031055)5.79721329
6telomere maintenance via recombination (GO:0000722)5.60814510
7mitotic recombination (GO:0006312)5.42087979
8mitotic chromosome condensation (GO:0007076)5.26035449
9DNA unwinding involved in DNA replication (GO:0006268)5.24425277
10DNA replication initiation (GO:0006270)4.94372752
11DNA replication checkpoint (GO:0000076)4.89623677
12mitotic metaphase plate congression (GO:0007080)4.78372579
13nucleotide-excision repair, DNA gap filling (GO:0006297)4.76088947
14histone exchange (GO:0043486)4.75394846
15DNA replication-independent nucleosome assembly (GO:0006336)4.70415174
16DNA replication-independent nucleosome organization (GO:0034724)4.70415174
17mitotic sister chromatid segregation (GO:0000070)4.65226884
18telomere maintenance via telomere lengthening (GO:0010833)4.41730146
19protein localization to kinetochore (GO:0034501)4.39726889
20DNA replication-dependent nucleosome assembly (GO:0006335)4.32021378
21DNA replication-dependent nucleosome organization (GO:0034723)4.32021378
22deoxyribonucleotide biosynthetic process (GO:0009263)4.31616048
23sister chromatid segregation (GO:0000819)4.30124276
24protein localization to chromosome, centromeric region (GO:0071459)4.27035696
25proteasome assembly (GO:0043248)4.25886119
26establishment of integrated proviral latency (GO:0075713)4.19295785
27DNA ligation (GO:0006266)4.14504004
28mitotic sister chromatid cohesion (GO:0007064)4.14267002
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.07901185
30metaphase plate congression (GO:0051310)4.07470945
31purine nucleobase biosynthetic process (GO:0009113)4.03829535
32folic acid-containing compound biosynthetic process (GO:0009396)3.96232898
33IMP biosynthetic process (GO:0006188)3.93779954
34kinetochore organization (GO:0051383)3.92837834
35regulation of centriole replication (GO:0046599)3.91975024
36nuclear pore complex assembly (GO:0051292)3.86538416
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80365156
38mitotic nuclear envelope disassembly (GO:0007077)3.77077901
39nucleobase biosynthetic process (GO:0046112)3.72656086
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72512653
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72305902
42regulation of double-strand break repair via homologous recombination (GO:0010569)3.71143300
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68615393
44chromatin assembly or disassembly (GO:0006333)3.66631964
45establishment of chromosome localization (GO:0051303)3.65051496
46non-recombinational repair (GO:0000726)3.61507299
47double-strand break repair via nonhomologous end joining (GO:0006303)3.61507299
48DNA topological change (GO:0006265)3.61335640
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56105693
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.56105693
51nuclear pore organization (GO:0006999)3.53848520
52G1/S transition of mitotic cell cycle (GO:0000082)3.53621839
53cell cycle G1/S phase transition (GO:0044843)3.53621839
54regulation of sister chromatid cohesion (GO:0007063)3.52767385
55establishment of viral latency (GO:0019043)3.51198418
56deoxyribose phosphate biosynthetic process (GO:0046385)3.50806911
572-deoxyribonucleotide biosynthetic process (GO:0009265)3.50806911
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50676205
59telomere maintenance (GO:0000723)3.48785199
60nuclear envelope disassembly (GO:0051081)3.47974469
61membrane disassembly (GO:0030397)3.47974469
62telomere organization (GO:0032200)3.46846357
63DNA catabolic process, exonucleolytic (GO:0000738)3.46054973
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45596994
65DNA double-strand break processing (GO:0000729)3.43819864
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43321045
67negative regulation of ligase activity (GO:0051352)3.43321045
68IMP metabolic process (GO:0046040)3.35561178
69regulation of chromosome segregation (GO:0051983)3.35559089
70chromosome segregation (GO:0007059)3.33465740
71ATP-dependent chromatin remodeling (GO:0043044)3.33168331
72ribosome assembly (GO:0042255)3.32904951
73protein K6-linked ubiquitination (GO:0085020)3.31376950
74transcription-coupled nucleotide-excision repair (GO:0006283)3.30788863
75formation of translation preinitiation complex (GO:0001731)3.28884848
76kinetochore assembly (GO:0051382)3.28878897
77spindle checkpoint (GO:0031577)3.28263924
78chromosome condensation (GO:0030261)3.27028309
79negative regulation of chromosome segregation (GO:0051985)3.26260809
80positive regulation of chromosome segregation (GO:0051984)3.24732796
81base-excision repair (GO:0006284)3.23062546
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22796832
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.19489902
84negative regulation of sister chromatid segregation (GO:0033046)3.19489902
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19489902
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19489902
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19489902
88mitotic cell cycle (GO:0000278)3.18019565
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17715092
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17715092
91mitotic spindle checkpoint (GO:0071174)3.16707406
92nucleobase-containing small molecule interconversion (GO:0015949)3.14558258
93protein localization to chromosome (GO:0034502)3.11198737
94mitotic spindle assembly checkpoint (GO:0007094)3.10253878
95spindle assembly checkpoint (GO:0071173)3.09652504
96pteridine-containing compound biosynthetic process (GO:0042559)3.08524872
97postreplication repair (GO:0006301)3.07552379
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06926565
99regulation of mitotic sister chromatid segregation (GO:0033047)3.03743117
100regulation of sister chromatid segregation (GO:0033045)3.03743117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.88074564
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.17078105
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11422779
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92558290
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69012986
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43606601
7AR_21909140_ChIP-Seq_LNCAP_Human3.20958132
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91576470
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85941546
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.84978129
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72375829
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.70497985
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70346951
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68735642
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.60813567
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45322596
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43174706
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37353125
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34053220
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34000589
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.30735392
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24877897
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07668788
24DCP1A_22483619_ChIP-Seq_HELA_Human2.06172326
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02462939
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01419974
27E2F7_22180533_ChIP-Seq_HELA_Human11.0203907
28FOXP3_21729870_ChIP-Seq_TREG_Human1.99999161
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98427006
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98277176
31VDR_23849224_ChIP-Seq_CD4+_Human1.94621734
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94088492
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90183874
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86560103
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86461791
36ELK1_19687146_ChIP-ChIP_HELA_Human1.76752303
37GABP_19822575_ChIP-Seq_HepG2_Human1.76326409
38XRN2_22483619_ChIP-Seq_HELA_Human1.74910025
39TTF2_22483619_ChIP-Seq_HELA_Human1.73225685
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72476386
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72285458
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70281441
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59136069
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58547738
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57394559
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57107650
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52623364
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.51348279
49E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45638623
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44196378
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40398887
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36462054
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32463967
54KDM5A_27292631_Chip-Seq_BREAST_Human1.30707652
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26750800
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.26018436
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25445575
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19321203
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18734854
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.18502964
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17819811
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15927971
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10486810
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07269335
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06507550
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06061766
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03044850
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02647540
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00940249
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00258709
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99424177
72IRF1_19129219_ChIP-ChIP_H3396_Human0.96763284
73MYC_18940864_ChIP-ChIP_HL60_Human0.95981321
74CIITA_25753668_ChIP-Seq_RAJI_Human0.95454377
75ZNF263_19887448_ChIP-Seq_K562_Human0.94974949
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94686352
77TFEB_21752829_ChIP-Seq_HELA_Human0.93020199
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92469561
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92380651
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91409655
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90761293
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90543230
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87354287
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86545900
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85130881
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.83422098
87MYC_22102868_ChIP-Seq_BL_Human0.82376224
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.81983811
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80429231
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79987720
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79848300
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79066529
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76684367
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75545271
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71759816
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71674622
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.70346507
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.66858611
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.64452730
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.61158136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability6.79176315
2MP0003693_abnormal_embryo_hatching5.36021748
3MP0003111_abnormal_nucleus_morphology5.11418139
4MP0008057_abnormal_DNA_replication4.73617883
5MP0008058_abnormal_DNA_repair4.70049383
6MP0004957_abnormal_blastocyst_morpholog4.67717221
7MP0003077_abnormal_cell_cycle4.27066478
8MP0008932_abnormal_embryonic_tissue3.44009992
9MP0008007_abnormal_cellular_replicative2.92847382
10MP0009697_abnormal_copulation2.82767908
11MP0003806_abnormal_nucleotide_metabolis2.55954441
12MP0003786_premature_aging2.33336059
13MP0001730_embryonic_growth_arrest2.33142821
14MP0000350_abnormal_cell_proliferation2.19803263
15MP0004147_increased_porphyrin_level2.13799155
16MP0003718_maternal_effect2.04164905
17MP0010307_abnormal_tumor_latency1.97156527
18MP0006035_abnormal_mitochondrial_morpho1.78616280
19MP0002396_abnormal_hematopoietic_system1.73667571
20MP0001697_abnormal_embryo_size1.71299802
21MP0010352_gastrointestinal_tract_polyps1.65728905
22MP0000313_abnormal_cell_death1.63737741
23MP0002080_prenatal_lethality1.63190115
24MP0005380_embryogenesis_phenotype1.62373797
25MP0001672_abnormal_embryogenesis/_devel1.62373797
26MP0006036_abnormal_mitochondrial_physio1.56590322
27MP0002019_abnormal_tumor_incidence1.49601256
28MP0000358_abnormal_cell_content/1.45335224
29MP0008877_abnormal_DNA_methylation1.45268122
30MP0002210_abnormal_sex_determination1.42005837
31MP0003984_embryonic_growth_retardation1.30319451
32MP0001929_abnormal_gametogenesis1.27766242
33MP0002088_abnormal_embryonic_growth/wei1.23769562
34MP0002085_abnormal_embryonic_tissue1.23013796
35MP0003186_abnormal_redox_activity1.21438595
36MP0003941_abnormal_skin_development1.19705442
37MP0009672_abnormal_birth_weight1.18740517
38MP0001145_abnormal_male_reproductive1.14493882
39MP0001346_abnormal_lacrimal_gland1.14275779
40MP0002086_abnormal_extraembryonic_tissu1.11471004
41MP0005501_abnormal_skin_physiology1.08369899
42MP0003890_abnormal_embryonic-extraembry1.05423432
43MP0002084_abnormal_developmental_patter1.04804269
44MP0002877_abnormal_melanocyte_morpholog1.04476197
45MP0000653_abnormal_sex_gland1.04280255
46MP0000490_abnormal_crypts_of1.03628717
47MP0004185_abnormal_adipocyte_glucose1.00801484
48MP0001727_abnormal_embryo_implantation1.00491991
49MP0002796_impaired_skin_barrier1.00121022
50MP0001529_abnormal_vocalization0.98296930
51MP0003315_abnormal_perineum_morphology0.97222861
52MP0002163_abnormal_gland_morphology0.96152594
53MP0001881_abnormal_mammary_gland0.95066491
54MP0004197_abnormal_fetal_growth/weight/0.94690206
55MP0005384_cellular_phenotype0.93529230
56MP0001661_extended_life_span0.92642692
57MP0001119_abnormal_female_reproductive0.90902189
58MP0002160_abnormal_reproductive_system0.89104278
59MP0001764_abnormal_homeostasis0.86632301
60MP0002006_tumorigenesis0.83136623
61MP0005621_abnormal_cell_physiology0.82192706
62MP0000703_abnormal_thymus_morphology0.80319237
63MP0000372_irregular_coat_pigmentation0.71543725
64MP0003950_abnormal_plasma_membrane0.71429118
65MP0002398_abnormal_bone_marrow0.71089619
66MP0003699_abnormal_female_reproductive0.70171414
67MP0002166_altered_tumor_susceptibility0.69830888
68MP0001293_anophthalmia0.69658902
69MP0009703_decreased_birth_body0.68200973
70MP0001853_heart_inflammation0.67649838
71MP0010234_abnormal_vibrissa_follicle0.67520157
72MP0000689_abnormal_spleen_morphology0.67489331
73MP0000627_abnormal_mammary_gland0.66869432
74MP0006292_abnormal_olfactory_placode0.66846021
75MP0002722_abnormal_immune_system0.66307792
76MP0008995_early_reproductive_senescence0.66304808
77MP0003698_abnormal_male_reproductive0.66138751
78MP0004233_abnormal_muscle_weight0.66118763
79MP0002009_preneoplasia0.64999369
80MP0003943_abnormal_hepatobiliary_system0.64772892
81MP0003567_abnormal_fetal_cardiomyocyte0.63453579
82MP0003656_abnormal_erythrocyte_physiolo0.62610837
83MP0002161_abnormal_fertility/fecundity0.62527715
84MP0003221_abnormal_cardiomyocyte_apopto0.61956433
85MP0009333_abnormal_splenocyte_physiolog0.61805577
86MP0002111_abnormal_tail_morphology0.61475452
87MP0005379_endocrine/exocrine_gland_phen0.59352060
88MP0004808_abnormal_hematopoietic_stem0.58929738
89MP0008260_abnormal_autophagy0.56100047
90MP0002429_abnormal_blood_cell0.55431892
91MP0005389_reproductive_system_phenotype0.54615178
92MP0006072_abnormal_retinal_apoptosis0.53891955
93MP0000598_abnormal_liver_morphology0.52189995
94MP0003763_abnormal_thymus_physiology0.52007588
95MP0008789_abnormal_olfactory_epithelium0.51420702
96MP0005451_abnormal_body_composition0.50787400
97MP0005395_other_phenotype0.50307193
98MP0002970_abnormal_white_adipose0.50248712
99MP0005266_abnormal_metabolism0.49193934
100MP0003937_abnormal_limbs/digits/tail_de0.46999607

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)7.09592381
2Chromsome breakage (HP:0040012)6.49594201
3Abnormality of the preputium (HP:0100587)4.29660797
4Meckel diverticulum (HP:0002245)4.27802255
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.20773801
6Abnormality of chromosome stability (HP:0003220)4.19286297
7Birth length less than 3rd percentile (HP:0003561)4.13055942
8Abnormality of the ileum (HP:0001549)4.05503573
9Microvesicular hepatic steatosis (HP:0001414)3.63489111
10Small intestinal stenosis (HP:0012848)3.58868179
11Duodenal stenosis (HP:0100867)3.58868179
12Abnormality of glycolysis (HP:0004366)3.46433914
13Increased serum pyruvate (HP:0003542)3.33257923
14Multiple enchondromatosis (HP:0005701)3.09421603
15Medulloblastoma (HP:0002885)3.08067923
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.04647967
17Myelodysplasia (HP:0002863)2.98151558
18Abnormality of the carotid arteries (HP:0005344)2.92228892
19Nephroblastoma (Wilms tumor) (HP:0002667)2.81919440
20Abnormality of the duodenum (HP:0002246)2.81758047
21Abnormality of the labia minora (HP:0012880)2.79680828
22Clubbing of toes (HP:0100760)2.74400711
23Ependymoma (HP:0002888)2.72731590
24Increased nuchal translucency (HP:0010880)2.71565565
25Embryonal renal neoplasm (HP:0011794)2.63444753
26Acute encephalopathy (HP:0006846)2.55767423
27Abnormal gallbladder physiology (HP:0012438)2.51573716
28Cholecystitis (HP:0001082)2.51573716
29Abnormal lung lobation (HP:0002101)2.47416730
30Carpal bone hypoplasia (HP:0001498)2.46270317
31Reduced antithrombin III activity (HP:0001976)2.41312433
32Acute necrotizing encephalopathy (HP:0006965)2.37917754
33Abnormal mitochondria in muscle tissue (HP:0008316)2.36128213
34Pancytopenia (HP:0001876)2.35605063
35Increased serum lactate (HP:0002151)2.34732507
36Sloping forehead (HP:0000340)2.32019200
37Aplastic anemia (HP:0001915)2.27850741
38Absent radius (HP:0003974)2.27836617
39Reticulocytopenia (HP:0001896)2.27218236
40Increased hepatocellular lipid droplets (HP:0006565)2.27125260
41Abnormality of the fetal cardiovascular system (HP:0010948)2.26475200
42Abnormal umbilical cord blood vessels (HP:0011403)2.26475200
43Single umbilical artery (HP:0001195)2.26475200
44Volvulus (HP:0002580)2.22313339
45Increased CSF lactate (HP:0002490)2.21653984
46Bone marrow hypocellularity (HP:0005528)2.21445235
47Colon cancer (HP:0003003)2.19716994
48Cafe-au-lait spot (HP:0000957)2.19525660
49IgM deficiency (HP:0002850)2.17738311
50Rhabdomyosarcoma (HP:0002859)2.17035161
51Type I transferrin isoform profile (HP:0003642)2.16754940
52Hypoplastic pelvis (HP:0008839)2.13327655
53Abnormality of the umbilical cord (HP:0010881)2.12020722
54Absent forearm bone (HP:0003953)2.11191469
55Aplasia involving forearm bones (HP:0009822)2.11191469
56Triphalangeal thumb (HP:0001199)2.10093069
57Horseshoe kidney (HP:0000085)2.09777156
58Lipid accumulation in hepatocytes (HP:0006561)2.07916249
59Cerebral hypomyelination (HP:0006808)2.06174684
60Neoplasm of the adrenal gland (HP:0100631)2.04963115
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04666466
62Postnatal microcephaly (HP:0005484)2.04148212
63Agammaglobulinemia (HP:0004432)2.00961076
64Cortical dysplasia (HP:0002539)2.00875393
65Mitochondrial inheritance (HP:0001427)2.00865588
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00367309
67Premature ovarian failure (HP:0008209)1.99098807
68Glioma (HP:0009733)1.97732355
69Hepatocellular necrosis (HP:0001404)1.97720138
70Secondary amenorrhea (HP:0000869)1.96938625
71Hepatic necrosis (HP:0002605)1.96689887
72Ectopic kidney (HP:0000086)1.96354638
73Short thumb (HP:0009778)1.95199932
74Irregular epiphyses (HP:0010582)1.94726397
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93456333
76Abnormality of alanine metabolism (HP:0010916)1.93456333
77Hyperalaninemia (HP:0003348)1.93456333
78Cerebral edema (HP:0002181)1.92119603
79Selective tooth agenesis (HP:0001592)1.91948254
80Breast hypoplasia (HP:0003187)1.91763759
81Lactic acidosis (HP:0003128)1.91405175
82Choanal atresia (HP:0000453)1.90362446
83Arteriovenous malformation (HP:0100026)1.90289157
84Cleft eyelid (HP:0000625)1.89166892
85Poikiloderma (HP:0001029)1.87678743
86Rough bone trabeculation (HP:0100670)1.87084245
87Facial cleft (HP:0002006)1.85477796
88Proximal placement of thumb (HP:0009623)1.85297517
89Neoplasm of the colon (HP:0100273)1.85065365
90Microglossia (HP:0000171)1.84206903
91Abnormality of the anterior horn cell (HP:0006802)1.83865345
92Degeneration of anterior horn cells (HP:0002398)1.83865345
93Embryonal neoplasm (HP:0002898)1.82567671
94Squamous cell carcinoma (HP:0002860)1.81356896
95Ovarian neoplasm (HP:0100615)1.81095455
96Agnosia (HP:0010524)1.80958630
97Abnormal protein glycosylation (HP:0012346)1.80650745
98Abnormal glycosylation (HP:0012345)1.80650745
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80650745
100Abnormal protein N-linked glycosylation (HP:0012347)1.80650745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.54285413
2BUB14.11676402
3ZAK3.60073110
4VRK23.57831039
5EIF2AK13.53887410
6NEK13.52220071
7TTK3.29132990
8PLK43.09873254
9SRPK13.02916013
10WEE12.93876479
11VRK12.75013995
12PBK2.61933647
13SCYL22.50740748
14EIF2AK32.42744092
15TSSK62.30463773
16PLK31.95959278
17PLK11.90106118
18MST41.85601197
19BRSK21.78328197
20BRSK11.73260908
21CHEK21.70865152
22CCNB11.57612794
23NME21.56020522
24AURKB1.55756775
25ATR1.54609048
26STK161.51793342
27SMG11.50359076
28TAF11.45418392
29TLK11.41004610
30CDK71.40523020
31TRIM281.38514581
32AURKA1.36564977
33TESK21.26706977
34CDK81.26155823
35MKNK11.24661712
36EIF2AK21.15052901
37NUAK11.05319372
38NEK21.03664823
39CHEK11.03361453
40NME11.01714938
41MKNK20.99987982
42PAK40.96603994
43MAP3K80.87213482
44PASK0.85961240
45ATM0.84109048
46DAPK10.84034665
47KDR0.83891947
48BCKDK0.83613767
49STK40.81451020
50RPS6KB20.76259340
51CSNK1G30.72840247
52CDK40.66849722
53ALK0.65454568
54STK100.64110516
55BRAF0.62111147
56NEK90.60951642
57CDK10.58210062
58MELK0.57899136
59CSNK1G10.57215959
60CDK90.55792300
61MAP3K120.55609120
62PNCK0.53782963
63CSNK2A10.52365553
64CDK20.52348729
65MST1R0.52193894
66CSNK1A1L0.51876418
67CLK10.51238808
68CSNK2A20.50791108
69RPS6KA50.46826330
70CDK60.46104653
71CSNK1G20.43989302
72BCR0.43757173
73AKT20.42981360
74CDK180.42386186
75ARAF0.40284744
76PAK10.40232720
77CDK150.39184569
78CDK140.37975241
79CDK11A0.37855929
80CDK120.37593838
81RPS6KA40.35704328
82MAPKAPK50.34592740
83STK30.30965210
84PLK20.29541573
85PIM10.28802266
86TAOK10.28770772
87BMPR1B0.27954454
88CDK30.26994527
89DAPK30.26614594
90SIK30.25857997
91ERBB30.25081652
92PRKDC0.24193724
93PDK20.23790690
94RAF10.23529655
95PIM20.23050835
96PRKCI0.20600762
97LATS10.20037887
98CSNK1E0.17163792
99TESK10.15800010
100TAOK20.15122671

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.78480069
2Mismatch repair_Homo sapiens_hsa034305.01531641
3Proteasome_Homo sapiens_hsa030503.85320966
4Base excision repair_Homo sapiens_hsa034103.43168517
5Homologous recombination_Homo sapiens_hsa034403.21548778
6Nucleotide excision repair_Homo sapiens_hsa034202.92042978
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75979841
8Fanconi anemia pathway_Homo sapiens_hsa034602.75313951
9Non-homologous end-joining_Homo sapiens_hsa034502.74746826
10One carbon pool by folate_Homo sapiens_hsa006702.64253300
11Cell cycle_Homo sapiens_hsa041102.61469352
12Spliceosome_Homo sapiens_hsa030402.26061299
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23940991
14RNA transport_Homo sapiens_hsa030132.16774831
15Pyrimidine metabolism_Homo sapiens_hsa002402.11728360
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04040138
17RNA polymerase_Homo sapiens_hsa030201.91502847
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87284693
19Protein export_Homo sapiens_hsa030601.59736803
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.53088912
21Folate biosynthesis_Homo sapiens_hsa007901.52761063
22Biosynthesis of amino acids_Homo sapiens_hsa012301.47061285
23Ribosome_Homo sapiens_hsa030101.46523575
24Sulfur relay system_Homo sapiens_hsa041221.45334164
25Systemic lupus erythematosus_Homo sapiens_hsa053221.39513760
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35439433
27Fatty acid elongation_Homo sapiens_hsa000621.34423488
28RNA degradation_Homo sapiens_hsa030181.33986494
29Carbon metabolism_Homo sapiens_hsa012001.32188843
30Pyruvate metabolism_Homo sapiens_hsa006201.31187958
31Basal transcription factors_Homo sapiens_hsa030221.25337015
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24071931
33Purine metabolism_Homo sapiens_hsa002301.20080160
34mRNA surveillance pathway_Homo sapiens_hsa030151.18261915
35Propanoate metabolism_Homo sapiens_hsa006401.10790060
36Oocyte meiosis_Homo sapiens_hsa041141.06930609
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06696078
38p53 signaling pathway_Homo sapiens_hsa041151.06241291
39Parkinsons disease_Homo sapiens_hsa050120.95154799
40Pentose phosphate pathway_Homo sapiens_hsa000300.94886388
41Alcoholism_Homo sapiens_hsa050340.87364824
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86617556
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86387538
44Steroid biosynthesis_Homo sapiens_hsa001000.85895236
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85387221
46Oxidative phosphorylation_Homo sapiens_hsa001900.82398583
47Vitamin B6 metabolism_Homo sapiens_hsa007500.81775751
48Huntingtons disease_Homo sapiens_hsa050160.79468479
49Glutathione metabolism_Homo sapiens_hsa004800.76622935
50Primary immunodeficiency_Homo sapiens_hsa053400.75982733
51N-Glycan biosynthesis_Homo sapiens_hsa005100.75661253
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72856139
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71093478
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68634260
55Viral carcinogenesis_Homo sapiens_hsa052030.68535453
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68512310
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65858253
58Epstein-Barr virus infection_Homo sapiens_hsa051690.65515886
59Selenocompound metabolism_Homo sapiens_hsa004500.61247050
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58915173
61Fatty acid metabolism_Homo sapiens_hsa012120.57060588
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56584518
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.55529266
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55327591
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47382622
66Metabolic pathways_Homo sapiens_hsa011000.46444846
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41701847
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39267352
69Herpes simplex infection_Homo sapiens_hsa051680.38192432
70Alzheimers disease_Homo sapiens_hsa050100.34785155
71Fructose and mannose metabolism_Homo sapiens_hsa000510.33510514
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33141328
73HTLV-I infection_Homo sapiens_hsa051660.31669737
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26938128
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.26807824
76Galactose metabolism_Homo sapiens_hsa000520.21647594
77Thyroid cancer_Homo sapiens_hsa052160.21522087
78Lysine degradation_Homo sapiens_hsa003100.20981466
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19675007
80Fatty acid degradation_Homo sapiens_hsa000710.16777746
81Peroxisome_Homo sapiens_hsa041460.16120383
82MicroRNAs in cancer_Homo sapiens_hsa052060.15614774
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14166696
84Arginine and proline metabolism_Homo sapiens_hsa003300.12473491
85Sulfur metabolism_Homo sapiens_hsa009200.12452462
86Butanoate metabolism_Homo sapiens_hsa006500.12299835
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11727766
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.10447470
89Shigellosis_Homo sapiens_hsa051310.10281535
90Pancreatic cancer_Homo sapiens_hsa052120.09432024
91Antigen processing and presentation_Homo sapiens_hsa046120.08823248
92Small cell lung cancer_Homo sapiens_hsa052220.08271317
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07177875
94Hepatitis B_Homo sapiens_hsa051610.06217901
95Apoptosis_Homo sapiens_hsa042100.05627678
96Phenylalanine metabolism_Homo sapiens_hsa003600.05179697
97TGF-beta signaling pathway_Homo sapiens_hsa043500.04633106
98Bladder cancer_Homo sapiens_hsa052190.00166000
99Measles_Homo sapiens_hsa05162-0.0500240
100Colorectal cancer_Homo sapiens_hsa05210-0.0216940

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