DHODH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.13687909
2DNA replication initiation (GO:0006270)4.99420009
3maturation of SSU-rRNA (GO:0030490)4.96173087
4telomere maintenance via semi-conservative replication (GO:0032201)4.95907258
5DNA strand elongation (GO:0022616)4.92087715
6ribosomal small subunit assembly (GO:0000028)4.84195817
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.75283768
8DNA deamination (GO:0045006)4.55559420
9behavioral response to nicotine (GO:0035095)4.52029923
10water-soluble vitamin biosynthetic process (GO:0042364)4.48582850
11* nucleobase biosynthetic process (GO:0046112)4.44719891
12DNA unwinding involved in DNA replication (GO:0006268)4.40408535
13telomere maintenance via recombination (GO:0000722)4.39841078
14proteasome assembly (GO:0043248)4.37724604
15ribosomal small subunit biogenesis (GO:0042274)4.35401645
16respiratory chain complex IV assembly (GO:0008535)4.34009598
17ribosomal large subunit biogenesis (GO:0042273)4.31328468
18L-fucose catabolic process (GO:0042355)4.27805906
19fucose catabolic process (GO:0019317)4.27805906
20L-fucose metabolic process (GO:0042354)4.27805906
21viral transcription (GO:0019083)4.27272815
22purine nucleobase biosynthetic process (GO:0009113)4.22995342
23exogenous drug catabolic process (GO:0042738)4.22946826
24cellular ketone body metabolic process (GO:0046950)4.22593220
25drug catabolic process (GO:0042737)4.18283548
26translational termination (GO:0006415)4.18018164
27establishment of integrated proviral latency (GO:0075713)4.17164580
28rRNA modification (GO:0000154)4.15977467
29CENP-A containing nucleosome assembly (GO:0034080)4.15157425
30IMP biosynthetic process (GO:0006188)4.14996210
31telomere maintenance via telomere lengthening (GO:0010833)4.14922393
32indole-containing compound catabolic process (GO:0042436)4.11002937
33indolalkylamine catabolic process (GO:0046218)4.11002937
34tryptophan catabolic process (GO:0006569)4.11002937
35ribonucleoprotein complex biogenesis (GO:0022613)4.05961638
36chromatin remodeling at centromere (GO:0031055)4.02995912
37mitotic recombination (GO:0006312)4.01641610
38pseudouridine synthesis (GO:0001522)3.99574972
39DNA replication checkpoint (GO:0000076)3.97724231
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.96222565
41ribosome biogenesis (GO:0042254)3.89966974
42formation of translation preinitiation complex (GO:0001731)3.89586884
43rRNA processing (GO:0006364)3.88661897
44termination of RNA polymerase III transcription (GO:0006386)3.84570522
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.84570522
46translational elongation (GO:0006414)3.83394648
47kynurenine metabolic process (GO:0070189)3.82047191
48tryptophan metabolic process (GO:0006568)3.78986714
49protein complex biogenesis (GO:0070271)3.77755007
50oxidative demethylation (GO:0070989)3.77494151
51cytochrome complex assembly (GO:0017004)3.74641335
52rRNA metabolic process (GO:0016072)3.74423232
53mitotic metaphase plate congression (GO:0007080)3.72751339
54spliceosomal snRNP assembly (GO:0000387)3.70666951
55maturation of 5.8S rRNA (GO:0000460)3.70307938
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.70150267
57NADH dehydrogenase complex assembly (GO:0010257)3.70150267
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70150267
59ketone body metabolic process (GO:1902224)3.70049503
60IMP metabolic process (GO:0046040)3.69937306
61mitochondrial respiratory chain complex assembly (GO:0033108)3.69569668
62indolalkylamine metabolic process (GO:0006586)3.68272045
63protein localization to kinetochore (GO:0034501)3.67141987
64DNA replication-independent nucleosome organization (GO:0034724)3.65410963
65DNA replication-independent nucleosome assembly (GO:0006336)3.65410963
66DNA replication-dependent nucleosome assembly (GO:0006335)3.65001060
67DNA replication-dependent nucleosome organization (GO:0034723)3.65001060
68translational initiation (GO:0006413)3.64930866
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63307573
70cotranslational protein targeting to membrane (GO:0006613)3.60536068
71S-adenosylmethionine metabolic process (GO:0046500)3.60525881
72transcription-coupled nucleotide-excision repair (GO:0006283)3.54515710
73protein targeting to ER (GO:0045047)3.54466892
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52791949
75rRNA methylation (GO:0031167)3.50289009
76ribosome assembly (GO:0042255)3.50101326
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48467825
78cellular component biogenesis (GO:0044085)3.45394576
79regulation of nuclear cell cycle DNA replication (GO:0033262)3.45313016
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43265501
81response to pheromone (GO:0019236)3.40306503
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39961271
83aromatic amino acid family catabolic process (GO:0009074)3.38991869
847-methylguanosine mRNA capping (GO:0006370)3.37324666
85ubiquinone biosynthetic process (GO:0006744)3.37202719
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36840721
87protein localization to endoplasmic reticulum (GO:0070972)3.36655592
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35773059
89establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35748825
90cellular protein complex disassembly (GO:0043624)3.35278659
91translation (GO:0006412)3.34850388
92RNA capping (GO:0036260)3.33581827
937-methylguanosine RNA capping (GO:0009452)3.33581827
94tRNA methylation (GO:0030488)3.32188083
95kinetochore organization (GO:0051383)3.32165989
96L-methionine salvage (GO:0071267)3.31670240
97L-methionine biosynthetic process (GO:0071265)3.31670240
98amino acid salvage (GO:0043102)3.31670240
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30592319
100glyoxylate metabolic process (GO:0046487)3.30265200
101mitochondrial DNA replication (GO:0006264)3.27510448
102folic acid-containing compound biosynthetic process (GO:0009396)3.26067245
103transcription elongation from RNA polymerase I promoter (GO:0006362)3.25599416
104ATP synthesis coupled proton transport (GO:0015986)3.25169153
105energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25169153
106kinetochore assembly (GO:0051382)3.24475997
107negative regulation of ligase activity (GO:0051352)3.23312415
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23312415
109viral life cycle (GO:0019058)3.23290591
110viral mRNA export from host cell nucleus (GO:0046784)3.21286442
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20931789
112histone exchange (GO:0043486)3.20921054
113mannosylation (GO:0097502)3.20261587
114establishment of viral latency (GO:0019043)3.17561012
115negative regulation of telomere maintenance (GO:0032205)3.16608206
116spliceosomal complex assembly (GO:0000245)3.16319128
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15886968
118amine catabolic process (GO:0009310)3.15146543
119cellular biogenic amine catabolic process (GO:0042402)3.15146543
120cullin deneddylation (GO:0010388)3.14535150
121cell cycle G1/S phase transition (GO:0044843)3.13766640
122G1/S transition of mitotic cell cycle (GO:0000082)3.13766640
123ncRNA processing (GO:0034470)3.12831532
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12744320
125quinone biosynthetic process (GO:1901663)3.12244499
126serine family amino acid catabolic process (GO:0009071)3.11345248
127termination of RNA polymerase I transcription (GO:0006363)3.10672870
128metaphase plate congression (GO:0051310)3.09911414
129transcription from RNA polymerase I promoter (GO:0006360)3.09739140
130preassembly of GPI anchor in ER membrane (GO:0016254)3.08850957
131ubiquinone metabolic process (GO:0006743)3.07254408
132protein-cofactor linkage (GO:0018065)3.06809124
133ncRNA metabolic process (GO:0034660)3.06484352
134deoxyribonucleotide biosynthetic process (GO:0009263)3.06358656
135protein deneddylation (GO:0000338)3.05863577
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04068481
137sulfation (GO:0051923)3.02117106
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00136450
139intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00136450
140DNA-dependent DNA replication (GO:0006261)2.99829399
141protein localization to chromosome, centromeric region (GO:0071459)2.99574461
142establishment of protein localization to mitochondrial membrane (GO:0090151)2.99313074
143regulation of mitochondrial translation (GO:0070129)2.98877250
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98527903
145positive regulation of fatty acid transport (GO:2000193)2.95993528
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95689902
147rRNA catabolic process (GO:0016075)2.89393443
148mitochondrial RNA metabolic process (GO:0000959)2.89378907
149piRNA metabolic process (GO:0034587)2.88158150
150replication fork processing (GO:0031297)2.86534353
151methionine biosynthetic process (GO:0009086)2.82947896
152reciprocal DNA recombination (GO:0035825)2.82672049
153reciprocal meiotic recombination (GO:0007131)2.82672049
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82128531
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82128531
156recombinational repair (GO:0000725)2.81897826
157nonmotile primary cilium assembly (GO:0035058)2.81768277
158tRNA processing (GO:0008033)2.81422564
159arginine metabolic process (GO:0006525)2.80589217
160aromatic amino acid family metabolic process (GO:0009072)2.79018472
161double-strand break repair via homologous recombination (GO:0000724)2.77279594
162somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71636342
163somatic hypermutation of immunoglobulin genes (GO:0016446)2.71636342
164tRNA modification (GO:0006400)2.70900170
165drug metabolic process (GO:0017144)2.70746357
166epoxygenase P450 pathway (GO:0019373)2.68593385
167aldehyde catabolic process (GO:0046185)2.67501261
168flavonoid metabolic process (GO:0009812)2.66545770
169peptidyl-histidine modification (GO:0018202)2.66326993
170cysteine metabolic process (GO:0006534)2.64306070
171mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64148647
172positive regulation of icosanoid secretion (GO:0032305)2.64063887
173alkaloid metabolic process (GO:0009820)2.63800665
174glycine metabolic process (GO:0006544)2.63727852
175vitamin biosynthetic process (GO:0009110)2.63231496
176detection of light stimulus involved in sensory perception (GO:0050962)2.59698472
177detection of light stimulus involved in visual perception (GO:0050908)2.59698472
178indole-containing compound metabolic process (GO:0042430)2.58533833
179L-phenylalanine catabolic process (GO:0006559)2.57979417
180erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57979417
181cytidine deamination (GO:0009972)2.55967480
182cytidine metabolic process (GO:0046087)2.55967480
183cytidine catabolic process (GO:0006216)2.55967480
184negative regulation of reactive oxygen species metabolic process (GO:2000378)2.55728311
185platelet dense granule organization (GO:0060155)2.54877049
186omega-hydroxylase P450 pathway (GO:0097267)2.53778860
187methionine metabolic process (GO:0006555)2.50862717
188regulation of hexokinase activity (GO:1903299)2.50027478
189regulation of glucokinase activity (GO:0033131)2.50027478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97673702
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.69208600
3ZNF274_21170338_ChIP-Seq_K562_Hela4.13751286
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01572796
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.65039873
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58351227
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56922657
8VDR_22108803_ChIP-Seq_LS180_Human3.52341481
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51162488
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.36308675
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.30072468
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25113130
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24551002
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20329382
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16698056
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15177611
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.13006262
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01821037
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93756119
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86520714
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.75153694
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68191398
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51876361
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49888011
25VDR_23849224_ChIP-Seq_CD4+_Human2.48001395
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41917181
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41413273
28XRN2_22483619_ChIP-Seq_HELA_Human2.34791044
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34023865
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.27692517
31FOXP3_21729870_ChIP-Seq_TREG_Human2.24842185
32IGF1R_20145208_ChIP-Seq_DFB_Human2.24163191
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20992263
34DCP1A_22483619_ChIP-Seq_HELA_Human2.15159986
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.12779905
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11214956
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09790675
38TTF2_22483619_ChIP-Seq_HELA_Human2.04453205
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02714858
40EWS_26573619_Chip-Seq_HEK293_Human1.99979366
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97523887
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.96124511
43GABP_19822575_ChIP-Seq_HepG2_Human1.90627209
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90566322
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88618248
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84887828
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83745126
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83237526
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82921749
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82347320
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81783502
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.81026485
53TP53_22573176_ChIP-Seq_HFKS_Human1.79615225
54AR_21909140_ChIP-Seq_LNCAP_Human1.78691368
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75957753
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.73428910
57ELK1_19687146_ChIP-ChIP_HELA_Human1.69667843
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67465958
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66726971
60ER_23166858_ChIP-Seq_MCF-7_Human1.66343117
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63815851
62CIITA_25753668_ChIP-Seq_RAJI_Human1.63428897
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61978045
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61691673
65FUS_26573619_Chip-Seq_HEK293_Human1.59355789
66* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57215037
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54397615
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50858813
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48637243
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47907712
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.47099993
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47099993
73GBX2_23144817_ChIP-Seq_PC3_Human1.46262500
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.46236632
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46086438
76AR_20517297_ChIP-Seq_VCAP_Human1.41205032
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38832787
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36655139
79MYC_18940864_ChIP-ChIP_HL60_Human1.36264009
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.34800143
81ERA_21632823_ChIP-Seq_H3396_Human1.34688143
82TAF15_26573619_Chip-Seq_HEK293_Human1.34099047
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33722268
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32237501
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31052413
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29799791
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29747465
88KDM5A_27292631_Chip-Seq_BREAST_Human1.27137467
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26653594
90NCOR_22424771_ChIP-Seq_293T_Human1.26278547
91NANOG_19829295_ChIP-Seq_ESCs_Human1.22932246
92SOX2_19829295_ChIP-Seq_ESCs_Human1.22932246
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22039660
94P300_19829295_ChIP-Seq_ESCs_Human1.21679928
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21662534
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21642932
97HOXB7_26014856_ChIP-Seq_BT474_Human1.20376740
98BCAT_22108803_ChIP-Seq_LS180_Human1.20182596
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.20147222
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19551958
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18760433
102MYC_19829295_ChIP-Seq_ESCs_Human1.17674515
103IRF1_19129219_ChIP-ChIP_H3396_Human1.16486432
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15846230
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15333312
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14781064
107NANOG_20526341_ChIP-Seq_ESCs_Human1.14398047
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14189676
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12876803
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12876803
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12876803
112* P53_21459846_ChIP-Seq_SAOS-2_Human1.11805235
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11547278
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.09691349
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07952900
116EZH2_22144423_ChIP-Seq_EOC_Human1.07597230
117TAF2_19829295_ChIP-Seq_ESCs_Human1.07086892
118CBP_20019798_ChIP-Seq_JUKART_Human1.06466531
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06466531
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05243623
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04442974
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04192316
123GATA3_26560356_Chip-Seq_TH2_Human1.04081918
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03456016
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01461329
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99883976
127OCT4_20526341_ChIP-Seq_ESCs_Human0.99183031
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98809376
129KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98705422
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98611350
131* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98510507
132STAT3_23295773_ChIP-Seq_U87_Human0.98292942
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98252608
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97439668
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96482275
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94782032
137TCF4_23295773_ChIP-Seq_U87_Human0.94662897
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.93729554
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91894959
140TCF4_22108803_ChIP-Seq_LS180_Human0.91231398
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91193483
142KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90259514
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.90074284
144TFEB_21752829_ChIP-Seq_HELA_Human0.89965564
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89082821
146TP63_19390658_ChIP-ChIP_HaCaT_Human0.88657877
147RAC3_21632823_ChIP-Seq_H3396_Human0.88133491
148AR_25329375_ChIP-Seq_VCAP_Human0.87042410
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86729181
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86489897
151HTT_18923047_ChIP-ChIP_STHdh_Human0.85350919
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85016972
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84532725
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81767237
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81759481
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81376429
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80639579
158SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77876264
159SPI1_23547873_ChIP-Seq_NB4_Human0.74703446
160* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72321266
161FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72123857
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.71469278
163MYC_22102868_ChIP-Seq_BL_Human0.71298714
164SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70189048
165CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69924657
166SOX17_20123909_ChIP-Seq_XEN_Mouse0.68479562
167NANOG_16153702_ChIP-ChIP_HESCs_Human0.66821664
168CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66020334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.09799878
2MP0010094_abnormal_chromosome_stability4.92082786
3MP0003111_abnormal_nucleus_morphology4.57900307
4MP0004957_abnormal_blastocyst_morpholog4.52330902
5MP0008057_abnormal_DNA_replication3.99585327
6MP0003195_calcinosis3.91442048
7MP0008058_abnormal_DNA_repair3.86479818
8MP0003077_abnormal_cell_cycle3.84093040
9MP0008875_abnormal_xenobiotic_pharmacok3.64127059
10MP0008932_abnormal_embryonic_tissue3.07586276
11MP0008877_abnormal_DNA_methylation2.97123360
12MP0003123_paternal_imprinting2.90216394
13MP0002396_abnormal_hematopoietic_system2.80912526
14MP0008007_abnormal_cellular_replicative2.57345134
15MP0005360_urolithiasis2.54793465
16MP0002876_abnormal_thyroid_physiology2.52707945
17MP0003718_maternal_effect2.47118931
18MP0008872_abnormal_physiological_respon2.44955714
19MP0006292_abnormal_olfactory_placode2.37078671
20MP0003806_abnormal_nucleotide_metabolis2.34115064
21MP0005085_abnormal_gallbladder_physiolo2.24024249
22MP0002139_abnormal_hepatobiliary_system2.23054903
23MP0003786_premature_aging2.16542247
24MP0003136_yellow_coat_color2.12222730
25MP0005551_abnormal_eye_electrophysiolog2.12015374
26MP0009379_abnormal_foot_pigmentation2.07816488
27MP0005365_abnormal_bile_salt1.93292409
28MP0000350_abnormal_cell_proliferation1.86683642
29MP0005332_abnormal_amino_acid1.83462930
30MP0001968_abnormal_touch/_nociception1.79318501
31MP0000569_abnormal_digit_pigmentation1.78545244
32MP0002138_abnormal_hepatobiliary_system1.76811830
33MP0005645_abnormal_hypothalamus_physiol1.74700584
34MP0004043_abnormal_pH_regulation1.74331271
35MP0001730_embryonic_growth_arrest1.74130489
36MP0002132_abnormal_respiratory_system1.74100609
37MP0003121_genomic_imprinting1.73194517
38MP0002736_abnormal_nociception_after1.69359093
39MP0006036_abnormal_mitochondrial_physio1.64540614
40MP0010030_abnormal_orbit_morphology1.62353735
41MP0003252_abnormal_bile_duct1.61787223
42MP0006035_abnormal_mitochondrial_morpho1.60954294
43MP0000372_irregular_coat_pigmentation1.59043345
44MP0001485_abnormal_pinna_reflex1.56209603
45MP0001529_abnormal_vocalization1.53183600
46MP0005075_abnormal_melanosome_morpholog1.47783535
47MP0000490_abnormal_crypts_of1.47399520
48MP0000427_abnormal_hair_cycle1.41624413
49MP0001697_abnormal_embryo_size1.39223799
50MP0002638_abnormal_pupillary_reflex1.37433226
51MP0003011_delayed_dark_adaptation1.35331594
52MP0005646_abnormal_pituitary_gland1.34201948
53MP0010329_abnormal_lipoprotein_level1.32681737
54MP0004133_heterotaxia1.31575967
55MP0002080_prenatal_lethality1.30809357
56MP0003315_abnormal_perineum_morphology1.30124511
57MP0009046_muscle_twitch1.29590453
58MP0001873_stomach_inflammation1.27012361
59MP0002837_dystrophic_cardiac_calcinosis1.26860154
60MP0005253_abnormal_eye_physiology1.24462152
61MP0001188_hyperpigmentation1.24339650
62MP0002102_abnormal_ear_morphology1.24312009
63MP0003186_abnormal_redox_activity1.21262802
64MP0009697_abnormal_copulation1.20981145
65MP0009745_abnormal_behavioral_response1.20680683
66MP0004742_abnormal_vestibular_system1.20427263
67MP0001672_abnormal_embryogenesis/_devel1.18394101
68MP0005380_embryogenesis_phenotype1.18394101
69MP0002210_abnormal_sex_determination1.17965658
70MP0002085_abnormal_embryonic_tissue1.17399131
71MP0002653_abnormal_ependyma_morphology1.17378512
72MP0000313_abnormal_cell_death1.17192066
73MP0003567_abnormal_fetal_cardiomyocyte1.16428340
74MP0002019_abnormal_tumor_incidence1.14873394
75MP0009333_abnormal_splenocyte_physiolog1.14242024
76MP0002160_abnormal_reproductive_system1.13387566
77MP0001986_abnormal_taste_sensitivity1.11084871
78MP0001501_abnormal_sleep_pattern1.08340479
79MP0004885_abnormal_endolymph1.07553251
80MP0005377_hearing/vestibular/ear_phenot1.03880710
81MP0003878_abnormal_ear_physiology1.03880710
82MP0001145_abnormal_male_reproductive1.03751159
83MP0008995_early_reproductive_senescence1.01378398
84MP0002234_abnormal_pharynx_morphology0.98304771
85MP0001764_abnormal_homeostasis0.97653887
86MP0003763_abnormal_thymus_physiology0.96519666
87MP0005636_abnormal_mineral_homeostasis0.93289120
88MP0001293_anophthalmia0.92960030
89MP0001666_abnormal_nutrient_absorption0.92693311
90MP0000653_abnormal_sex_gland0.92604735
91MP0003984_embryonic_growth_retardation0.92263346
92MP0005389_reproductive_system_phenotype0.92096788
93MP0001929_abnormal_gametogenesis0.91406831
94MP0008260_abnormal_autophagy0.91115245
95MP0002272_abnormal_nervous_system0.90654821
96MP0006276_abnormal_autonomic_nervous0.90486788
97MP0002095_abnormal_skin_pigmentation0.90360341
98MP0004019_abnormal_vitamin_homeostasis0.89848894
99MP0001984_abnormal_olfaction0.89382390
100MP0002084_abnormal_developmental_patter0.88776926
101MP0002088_abnormal_embryonic_growth/wei0.88625553
102MP0005410_abnormal_fertilization0.88173652
103MP0005451_abnormal_body_composition0.86645523
104MP0005266_abnormal_metabolism0.86029281
105MP0004142_abnormal_muscle_tone0.85283352
106MP0003787_abnormal_imprinting0.85166527
107MP0004808_abnormal_hematopoietic_stem0.84984480
108MP0004145_abnormal_muscle_electrophysio0.84749718
109MP0005084_abnormal_gallbladder_morpholo0.84609422
110MP0002254_reproductive_system_inflammat0.84593058
111MP0001486_abnormal_startle_reflex0.83529271
112MP0006072_abnormal_retinal_apoptosis0.83416029
113MP0000703_abnormal_thymus_morphology0.81801693
114MP0000358_abnormal_cell_content/0.81167610
115MP0003698_abnormal_male_reproductive0.80205515
116MP0003938_abnormal_ear_development0.79264265
117MP0003137_abnormal_impulse_conducting0.78683239
118MP0001919_abnormal_reproductive_system0.78084889
119MP0005409_darkened_coat_color0.77165437
120MP0002086_abnormal_extraembryonic_tissu0.77114623
121MP0004147_increased_porphyrin_level0.77100117
122MP0001502_abnormal_circadian_rhythm0.76506958
123MP0003941_abnormal_skin_development0.75901968
124MP0001119_abnormal_female_reproductive0.75592116
125MP0001324_abnormal_eye_pigmentation0.75367669
126MP0004197_abnormal_fetal_growth/weight/0.74733224
127MP0002249_abnormal_larynx_morphology0.74608618
128MP0001905_abnormal_dopamine_level0.74507705
129MP0008775_abnormal_heart_ventricle0.74364096
130MP0005195_abnormal_posterior_eye0.72486681
131MP0002735_abnormal_chemical_nociception0.72447681
132MP0002722_abnormal_immune_system0.72216707
133MP0008789_abnormal_olfactory_epithelium0.72086812
134MP0002938_white_spotting0.71201717
135MP0003646_muscle_fatigue0.70946391
136MP0005174_abnormal_tail_pigmentation0.70570446
137MP0003950_abnormal_plasma_membrane0.70130386
138MP0002067_abnormal_sensory_capabilities0.69763123
139MP0002111_abnormal_tail_morphology0.69421171
140MP0000049_abnormal_middle_ear0.69122561
141MP0003119_abnormal_digestive_system0.68299689
142MP0009643_abnormal_urine_homeostasis0.67023785
143MP0002928_abnormal_bile_duct0.66905717
144MP0000538_abnormal_urinary_bladder0.66845672
145MP0004381_abnormal_hair_follicle0.66789875
146MP0000689_abnormal_spleen_morphology0.66562282
147MP0003890_abnormal_embryonic-extraembry0.66317605
148MP0002163_abnormal_gland_morphology0.65101510
149MP0002398_abnormal_bone_marrow0.63343521
150MP0001286_abnormal_eye_development0.62657397
151MP0002277_abnormal_respiratory_mucosa0.59930804
152MP0003937_abnormal_limbs/digits/tail_de0.57925421
153MP0005384_cellular_phenotype0.57911068
154MP0001727_abnormal_embryo_implantation0.54870011
155MP0000631_abnormal_neuroendocrine_gland0.54313455
156MP0002075_abnormal_coat/hair_pigmentati0.53931122
157MP0005395_other_phenotype0.53214642
158MP0002429_abnormal_blood_cell0.52863155
159MP0002751_abnormal_autonomic_nervous0.52666607

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.00678214
2Reticulocytopenia (HP:0001896)4.74786384
3Abnormality of cells of the erythroid lineage (HP:0012130)4.68191057
4Abnormal number of erythroid precursors (HP:0012131)4.49803364
5Pancreatic cysts (HP:0001737)4.25897097
6Breast hypoplasia (HP:0003187)4.06774973
7Abnormality of midbrain morphology (HP:0002418)4.04276517
8Molar tooth sign on MRI (HP:0002419)4.04276517
9Chromsome breakage (HP:0040012)4.03467108
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01456182
11Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01456182
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90600417
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.68259721
14Pancreatic fibrosis (HP:0100732)3.63383260
15Oral leukoplakia (HP:0002745)3.58146106
16Cerebral hypomyelination (HP:0006808)3.57172501
17Aplastic anemia (HP:0001915)3.46502189
18Congenital stationary night blindness (HP:0007642)3.45741576
19Macrocytic anemia (HP:0001972)3.38236810
20Abnormality of glycolysis (HP:0004366)3.37485005
21Increased serum pyruvate (HP:0003542)3.37485005
22True hermaphroditism (HP:0010459)3.37311860
23Pallor (HP:0000980)3.34553992
24Microvesicular hepatic steatosis (HP:0001414)3.30998104
25Hepatocellular necrosis (HP:0001404)3.22011430
26Increased serum lactate (HP:0002151)3.20079175
27Abnormality of the renal cortex (HP:0011035)3.18632699
28Hyperglycinemia (HP:0002154)3.17192827
293-Methylglutaconic aciduria (HP:0003535)3.15278748
30Carpal bone hypoplasia (HP:0001498)3.12258410
31Patellar aplasia (HP:0006443)3.09331616
32Type II lissencephaly (HP:0007260)3.08550922
33Increased CSF lactate (HP:0002490)3.07967329
34Mitochondrial inheritance (HP:0001427)3.06339812
35Nephronophthisis (HP:0000090)3.06100855
36Duplicated collecting system (HP:0000081)3.01979872
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01844962
38Acute necrotizing encephalopathy (HP:0006965)2.98830004
39Abnormality of the preputium (HP:0100587)2.98727928
40Hyperglycinuria (HP:0003108)2.96375281
41Renal cortical cysts (HP:0000803)2.94825488
42Increased hepatocellular lipid droplets (HP:0006565)2.87104332
43Rough bone trabeculation (HP:0100670)2.85742316
44Aplasia/Hypoplasia of the patella (HP:0006498)2.85233565
45Abnormal mitochondria in muscle tissue (HP:0008316)2.81497838
46Abnormality of glycine metabolism (HP:0010895)2.78845162
47Abnormality of serine family amino acid metabolism (HP:0010894)2.78845162
48Meckel diverticulum (HP:0002245)2.76902012
49Abnormality of the renal collecting system (HP:0004742)2.76725825
50Pendular nystagmus (HP:0012043)2.72230769
51Abnormality of the labia minora (HP:0012880)2.71383713
52Colon cancer (HP:0003003)2.69032473
53Hepatic necrosis (HP:0002605)2.68521846
54Abnormality of the ileum (HP:0001549)2.66256138
55Attenuation of retinal blood vessels (HP:0007843)2.64243353
56Abnormality of chromosome stability (HP:0003220)2.63214869
57Absent radius (HP:0003974)2.62726519
58Medial flaring of the eyebrow (HP:0010747)2.61520614
59Type 2 muscle fiber atrophy (HP:0003554)2.56772757
60Abnormality of the renal medulla (HP:0100957)2.55341883
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53951222
62Lipid accumulation in hepatocytes (HP:0006561)2.53398784
63Aplasia involving forearm bones (HP:0009822)2.53287535
64Absent forearm bone (HP:0003953)2.53287535
65Ragged-red muscle fibers (HP:0003200)2.51941287
66Cystic liver disease (HP:0006706)2.51685542
67Type I transferrin isoform profile (HP:0003642)2.50061384
68Abolished electroretinogram (ERG) (HP:0000550)2.48472329
69Pancytopenia (HP:0001876)2.48284980
70Abnormality of serum amino acid levels (HP:0003112)2.48088529
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46059997
72Bone marrow hypocellularity (HP:0005528)2.46057498
73CNS hypomyelination (HP:0003429)2.45377668
74Polydipsia (HP:0001959)2.39840228
75Abnormal drinking behavior (HP:0030082)2.39840228
76Absent thumb (HP:0009777)2.39805763
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.39303003
78Chronic hepatic failure (HP:0100626)2.38614573
79Muscle fiber atrophy (HP:0100295)2.38062984
80Methylmalonic acidemia (HP:0002912)2.37771925
81Abnormality of the heme biosynthetic pathway (HP:0010472)2.36939790
82Selective tooth agenesis (HP:0001592)2.36561477
83Hyperventilation (HP:0002883)2.36050486
84Myelodysplasia (HP:0002863)2.33398425
85Bile duct proliferation (HP:0001408)2.33341856
86Abnormal biliary tract physiology (HP:0012439)2.33341856
87Exercise intolerance (HP:0003546)2.33017744
88Abnormality of alanine metabolism (HP:0010916)2.32544024
89Hyperalaninemia (HP:0003348)2.32544024
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32544024
91Large for gestational age (HP:0001520)2.32069247
9211 pairs of ribs (HP:0000878)2.32056234
93Lactic acidosis (HP:0003128)2.31747109
94Premature graying of hair (HP:0002216)2.30643582
95Ketosis (HP:0001946)2.30426260
96Supernumerary spleens (HP:0009799)2.29742873
97Tubular atrophy (HP:0000092)2.28414439
98Acute encephalopathy (HP:0006846)2.28064934
99Methylmalonic aciduria (HP:0012120)2.27546647
100Abnormal lung lobation (HP:0002101)2.27430179
101Sclerocornea (HP:0000647)2.26093920
102Renal Fanconi syndrome (HP:0001994)2.25994209
103Small intestinal stenosis (HP:0012848)2.24260277
104Duodenal stenosis (HP:0100867)2.24260277
105Delayed CNS myelination (HP:0002188)2.21880756
106Inability to walk (HP:0002540)2.21413126
107Abnormal trabecular bone morphology (HP:0100671)2.19758080
108Triphalangeal thumb (HP:0001199)2.18583442
109Progressive macrocephaly (HP:0004481)2.18433505
110Asplenia (HP:0001746)2.18017213
111Agnosia (HP:0010524)2.16964504
112Hypoplasia of the pons (HP:0012110)2.16816366
113Abnormality of the pons (HP:0007361)2.16585676
114Increased intramyocellular lipid droplets (HP:0012240)2.15815830
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13862202
116Medulloblastoma (HP:0002885)2.13714206
117Secondary amenorrhea (HP:0000869)2.12558192
118Congenital, generalized hypertrichosis (HP:0004540)2.11943563
119Lethargy (HP:0001254)2.11851574
120Degeneration of anterior horn cells (HP:0002398)2.11552715
121Abnormality of the anterior horn cell (HP:0006802)2.11552715
122Cerebellar dysplasia (HP:0007033)2.09671384
123Megaloblastic anemia (HP:0001889)2.07535050
124Horseshoe kidney (HP:0000085)2.07099286
125Respiratory failure (HP:0002878)2.06058538
126Congenital hepatic fibrosis (HP:0002612)2.05692748
127Gait imbalance (HP:0002141)2.05588434
128Congenital primary aphakia (HP:0007707)2.04105328
129Cerebral edema (HP:0002181)2.03374123
130Prolonged partial thromboplastin time (HP:0003645)2.02829692
131Furrowed tongue (HP:0000221)2.00542260
132Optic disc pallor (HP:0000543)1.99516948
133Cellular immunodeficiency (HP:0005374)1.99134373
134Poor head control (HP:0002421)1.98983542
135Microretrognathia (HP:0000308)1.98739576
136Emotional lability (HP:0000712)1.98037453
137Polyuria (HP:0000103)1.97893809
138Respiratory difficulties (HP:0002880)1.97307397
139Progressive inability to walk (HP:0002505)1.95918803
140Postnatal microcephaly (HP:0005484)1.95371734
141Sloping forehead (HP:0000340)1.93770420
142Severe muscular hypotonia (HP:0006829)1.93441385
143Ketoacidosis (HP:0001993)1.91691082
144Chorioretinal atrophy (HP:0000533)1.89812553
145Fair hair (HP:0002286)1.89159563
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.89138369
147Male pseudohermaphroditism (HP:0000037)1.88852303
148Progressive microcephaly (HP:0000253)1.88636299
149Premature ovarian failure (HP:0008209)1.88462129
150Abnormal rod and cone electroretinograms (HP:0008323)1.88153154
151Abnormality of pyrimidine metabolism (HP:0004353)1.87733189
152Exertional dyspnea (HP:0002875)1.87682494
153Nephrogenic diabetes insipidus (HP:0009806)1.87495270
154Tachypnea (HP:0002789)1.87172050
155Metabolic acidosis (HP:0001942)1.86548765
156Abnormality of urine glucose concentration (HP:0011016)1.84086885
157Glycosuria (HP:0003076)1.84086885
158Duplication of thumb phalanx (HP:0009942)1.82913288
159Abnormality of the duodenum (HP:0002246)1.81631272
160Concave nail (HP:0001598)1.81234022
161Tracheoesophageal fistula (HP:0002575)1.80841917
162Ureteral duplication (HP:0000073)1.79843632
163Trismus (HP:0000211)1.79738516
164IgG deficiency (HP:0004315)1.79648423
165Clumsiness (HP:0002312)1.79322904
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.78540786
167Lissencephaly (HP:0001339)1.78389434
168Postaxial foot polydactyly (HP:0001830)1.78190577
169Hypobetalipoproteinemia (HP:0003563)1.75256514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.75272161
2FRK4.63997234
3WEE14.49184663
4STK163.79298462
5EIF2AK13.67041072
6WNK43.34919184
7CDC73.25052227
8TSSK63.04526300
9SRPK13.00301645
10NME22.65537822
11VRK12.55866449
12NUAK12.54892019
13EIF2AK32.52540764
14GRK12.31605055
15TAOK32.23916634
16TLK12.23072672
17PLK42.21248772
18VRK22.18677893
19MAP4K22.16647530
20MKNK12.07829692
21TTK1.99892203
22WNK31.94023552
23INSRR1.93763179
24STK391.82705259
25OXSR11.81068750
26PLK11.75344934
27MKNK21.74690650
28CDK71.74380005
29NME11.63194939
30BRSK21.62812917
31RPS6KB21.57252549
32CCNB11.54196533
33CASK1.53915864
34PINK11.50568613
35NEK11.47964239
36CDK81.46304853
37EPHA21.39377799
38ATR1.38040276
39AURKB1.37589520
40ZAK1.37277321
41AURKA1.36245925
42NEK21.35531552
43MAP4K11.33247577
44PLK31.32506825
45PASK1.25918978
46TAF11.23542976
47DYRK31.20839719
48CHEK21.12977749
49ACVR1B1.12124047
50PNCK1.07732876
51MAP2K61.03860460
52BRSK11.03382079
53MAP3K81.00525901
54MAP3K120.98950394
55AKT30.97552676
56BRAF0.96717701
57ADRBK10.95437044
58CDK40.95063719
59EIF2AK20.95035401
60DAPK20.94609375
61MAP3K40.91707939
62MUSK0.90415669
63STK40.90093820
64CHEK10.88784108
65CDK190.87007719
66TRIM280.85925581
67PAK30.84242704
68STK100.82097321
69CSNK2A20.81433336
70PHKG10.81077386
71PHKG20.81077386
72PBK0.80822320
73MAP3K110.79860402
74CLK10.79435180
75CSNK2A10.75858287
76CAMKK20.74359574
77FLT30.73681890
78MST40.71555447
79BCKDK0.70711903
80MAP2K70.69621660
81TIE10.69611552
82MAP2K30.68591145
83TNIK0.68393902
84IKBKB0.65801147
85TESK20.65579507
86TGFBR10.64454893
87CSNK1G10.61698169
88PAK40.60877640
89CDK20.60706984
90PAK10.60303313
91MAPK150.59977202
92TAOK20.59854012
93PRKCG0.58775704
94CSNK1G20.56465647
95PRKCE0.55719629
96PRKCQ0.55284975
97ATM0.54939532
98PIM10.53919500
99DYRK20.53800275
100CSNK1A1L0.53546688
101YES10.53292301
102RPS6KA50.51560161
103DAPK10.51110531
104PIK3CA0.49243613
105KIT0.48047790
106CDK10.47395329
107PRKCI0.47067781
108ITK0.45547976
109TEC0.43317383
110MAPKAPK30.43157680
111BTK0.43077617
112MAP2K20.42281537
113IRAK30.40608933
114CSNK1A10.40496617
115PIM20.39303567
116PTK2B0.38986042
117NTRK30.38977235
118RPS6KA40.37761493
119KDR0.37374684
120MAPKAPK50.37250958
121CSNK1D0.37009283
122PRKACA0.36826607
123BMPR1B0.35997587
124IRAK40.34510767
125TNK20.34509402
126PRKAA10.33802747
127CHUK0.32349463
128SIK20.31340595
129PIK3CG0.31048943
130BMPR20.30751414
131MAP3K30.30231744
132GRK60.30226035
133PRKACB0.29109140
134ADRBK20.29014036
135MAPK130.28866098
136STK38L0.28517223
137MYLK0.28385421
138PRKAA20.28058526
139OBSCN0.27303949
140MELK0.26882688
141CSNK1E0.26141708
142CSNK1G30.25935181
143ABL20.25182850
144RPS6KB10.22145658
145TXK0.20992873
146ALK0.18521973
147PDK20.18270540
148NEK60.17585869
149PDK30.17312707

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.03187466
2Mismatch repair_Homo sapiens_hsa034304.35479331
3Ribosome_Homo sapiens_hsa030104.28667695
4Proteasome_Homo sapiens_hsa030503.79916722
5RNA polymerase_Homo sapiens_hsa030203.78543866
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40297407
7Homologous recombination_Homo sapiens_hsa034403.23981112
8Spliceosome_Homo sapiens_hsa030403.05795019
9Nucleotide excision repair_Homo sapiens_hsa034202.91138312
10* Pyrimidine metabolism_Homo sapiens_hsa002402.89635317
11Base excision repair_Homo sapiens_hsa034102.89317072
12RNA transport_Homo sapiens_hsa030132.67578506
13Caffeine metabolism_Homo sapiens_hsa002322.65952076
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51777266
15One carbon pool by folate_Homo sapiens_hsa006702.46832483
16Fanconi anemia pathway_Homo sapiens_hsa034602.27737326
17Butanoate metabolism_Homo sapiens_hsa006502.24173955
18Non-homologous end-joining_Homo sapiens_hsa034502.22261979
19Cell cycle_Homo sapiens_hsa041102.18056299
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04308679
21RNA degradation_Homo sapiens_hsa030182.03340387
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.99550399
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93657271
24Tryptophan metabolism_Homo sapiens_hsa003801.92032395
25Basal transcription factors_Homo sapiens_hsa030221.87864480
26Oxidative phosphorylation_Homo sapiens_hsa001901.84910547
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80224140
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80191199
29Retinol metabolism_Homo sapiens_hsa008301.77731316
30Chemical carcinogenesis_Homo sapiens_hsa052041.77623857
31Parkinsons disease_Homo sapiens_hsa050121.71841665
32Purine metabolism_Homo sapiens_hsa002301.64225855
33Nitrogen metabolism_Homo sapiens_hsa009101.57871632
34Protein export_Homo sapiens_hsa030601.54843215
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.54375746
36Peroxisome_Homo sapiens_hsa041461.50041394
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49985247
38Huntingtons disease_Homo sapiens_hsa050161.45966058
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39830268
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37238507
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.35993012
42Sulfur relay system_Homo sapiens_hsa041221.29048652
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28481533
44Fatty acid degradation_Homo sapiens_hsa000711.25732747
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25504401
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22055977
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21005232
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.20690025
49Folate biosynthesis_Homo sapiens_hsa007901.17230943
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.14104086
51mRNA surveillance pathway_Homo sapiens_hsa030151.11073493
52Sulfur metabolism_Homo sapiens_hsa009201.10884964
53Histidine metabolism_Homo sapiens_hsa003401.08892322
54Fat digestion and absorption_Homo sapiens_hsa049751.06231631
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.00739194
56Epstein-Barr virus infection_Homo sapiens_hsa051690.96768302
57Systemic lupus erythematosus_Homo sapiens_hsa053220.96602609
58p53 signaling pathway_Homo sapiens_hsa041150.95053992
59Alzheimers disease_Homo sapiens_hsa050100.93751659
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91767154
61beta-Alanine metabolism_Homo sapiens_hsa004100.90162788
62ABC transporters_Homo sapiens_hsa020100.83248821
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82689300
64Arginine biosynthesis_Homo sapiens_hsa002200.82618802
65Pentose phosphate pathway_Homo sapiens_hsa000300.81721465
66Biosynthesis of amino acids_Homo sapiens_hsa012300.81684639
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81648977
68Tyrosine metabolism_Homo sapiens_hsa003500.80532498
69Oocyte meiosis_Homo sapiens_hsa041140.77105168
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.77027714
71Complement and coagulation cascades_Homo sapiens_hsa046100.76272761
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75405825
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72525258
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67195156
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64821387
76Glycerolipid metabolism_Homo sapiens_hsa005610.64521412
77Glutathione metabolism_Homo sapiens_hsa004800.63119844
78Vitamin digestion and absorption_Homo sapiens_hsa049770.63049856
79Nicotine addiction_Homo sapiens_hsa050330.61498794
80Carbon metabolism_Homo sapiens_hsa012000.60390317
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59973835
82Fatty acid metabolism_Homo sapiens_hsa012120.57967440
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57933192
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57106955
85Phenylalanine metabolism_Homo sapiens_hsa003600.57076739
86* Metabolic pathways_Homo sapiens_hsa011000.56090309
87Lysine degradation_Homo sapiens_hsa003100.55021396
88Selenocompound metabolism_Homo sapiens_hsa004500.50708524
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48447293
90Herpes simplex infection_Homo sapiens_hsa051680.47428633
91Vitamin B6 metabolism_Homo sapiens_hsa007500.46595153
92Taste transduction_Homo sapiens_hsa047420.46092053
93Fructose and mannose metabolism_Homo sapiens_hsa000510.44936315
94Alcoholism_Homo sapiens_hsa050340.44273947
95Mineral absorption_Homo sapiens_hsa049780.44255220
96Starch and sucrose metabolism_Homo sapiens_hsa005000.43565122
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43152178
98Arachidonic acid metabolism_Homo sapiens_hsa005900.43070019
99Viral carcinogenesis_Homo sapiens_hsa052030.42782493
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40956594
101Bile secretion_Homo sapiens_hsa049760.38946001
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38862909
103Olfactory transduction_Homo sapiens_hsa047400.37659285
104Cardiac muscle contraction_Homo sapiens_hsa042600.35853109
105Linoleic acid metabolism_Homo sapiens_hsa005910.33443268
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33184483
107Arginine and proline metabolism_Homo sapiens_hsa003300.32720681
108Pyruvate metabolism_Homo sapiens_hsa006200.28906877
109Antigen processing and presentation_Homo sapiens_hsa046120.27754189
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26451824
111Galactose metabolism_Homo sapiens_hsa000520.26215895
112Primary immunodeficiency_Homo sapiens_hsa053400.25952817
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25335287
114Regulation of autophagy_Homo sapiens_hsa041400.25303050
115Fatty acid elongation_Homo sapiens_hsa000620.22728080
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21010214
117N-Glycan biosynthesis_Homo sapiens_hsa005100.20341830
118HTLV-I infection_Homo sapiens_hsa051660.18356681
119Sphingolipid metabolism_Homo sapiens_hsa006000.14666358
120Ether lipid metabolism_Homo sapiens_hsa005650.12856809
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12648485
122Thyroid cancer_Homo sapiens_hsa052160.12441523
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11473079
124Phototransduction_Homo sapiens_hsa047440.11047004
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09101601
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06677574
127Collecting duct acid secretion_Homo sapiens_hsa049660.06602602
128Propanoate metabolism_Homo sapiens_hsa006400.04893218
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04143765
130Legionellosis_Homo sapiens_hsa051340.03948531
131Hematopoietic cell lineage_Homo sapiens_hsa046400.02427709
132Basal cell carcinoma_Homo sapiens_hsa052170.01519598
133Renin-angiotensin system_Homo sapiens_hsa046140.01089022
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00219466
135Pathways in cancer_Homo sapiens_hsa05200-0.0491799
136Shigellosis_Homo sapiens_hsa05131-0.0483136
137Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0433518
138Asthma_Homo sapiens_hsa05310-0.0411973
139TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0297988
140Measles_Homo sapiens_hsa05162-0.0277098
141SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0112124
142MicroRNAs in cancer_Homo sapiens_hsa05206-0.0079362
143Small cell lung cancer_Homo sapiens_hsa05222-0.0026724

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