DHPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heart field specification (GO:0003128)6.26587250
2secondary heart field specification (GO:0003139)6.26587250
3peptidyl-arginine omega-N-methylation (GO:0035247)5.74554448
4DNA deamination (GO:0045006)5.69960088
5cardiac ventricle formation (GO:0003211)5.49622810
6viral transcription (GO:0019083)5.46545886
7ribosomal small subunit biogenesis (GO:0042274)5.45879693
8maturation of SSU-rRNA (GO:0030490)5.29699832
9translational termination (GO:0006415)5.27362516
10histone arginine methylation (GO:0034969)5.17881187
11ribosomal large subunit biogenesis (GO:0042273)5.13575210
12ribosomal small subunit assembly (GO:0000028)5.10439857
13cardiac chamber formation (GO:0003207)4.99437346
14peptidyl-arginine N-methylation (GO:0035246)4.76590941
15peptidyl-arginine methylation (GO:0018216)4.76590941
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70797748
17translational elongation (GO:0006414)4.68829191
18nucleosome disassembly (GO:0006337)4.65369003
19protein-DNA complex disassembly (GO:0032986)4.65369003
20cotranslational protein targeting to membrane (GO:0006613)4.64142211
21protein targeting to ER (GO:0045047)4.60524154
22spliceosomal snRNP assembly (GO:0000387)4.59855864
23translational initiation (GO:0006413)4.51520425
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36503195
25protein localization to endoplasmic reticulum (GO:0070972)4.35524027
26ribonucleoprotein complex biogenesis (GO:0022613)4.32867337
27proteasome assembly (GO:0043248)4.29050535
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.27800774
29cellular protein complex disassembly (GO:0043624)4.23927631
30regulation of translation in response to stress (GO:0043555)4.23275763
31protein complex disassembly (GO:0043241)4.20621716
32specification of organ identity (GO:0010092)4.17041052
33protein complex biogenesis (GO:0070271)4.15255740
34viral life cycle (GO:0019058)4.14802073
35macromolecular complex disassembly (GO:0032984)4.05546842
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94732574
37* translation (GO:0006412)3.93161484
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92983840
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.92983840
40NADH dehydrogenase complex assembly (GO:0010257)3.92983840
41mitochondrial respiratory chain complex assembly (GO:0033108)3.89987545
42protein insertion into membrane (GO:0051205)3.89062462
43rRNA processing (GO:0006364)3.86404584
44cullin deneddylation (GO:0010388)3.86022946
45formation of translation preinitiation complex (GO:0001731)3.79433719
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74301785
47spliceosomal complex assembly (GO:0000245)3.72648725
48rRNA metabolic process (GO:0016072)3.72416124
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.70185122
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69902264
51negative regulation of ligase activity (GO:0051352)3.69902264
52ribosome biogenesis (GO:0042254)3.67819444
53pyrimidine nucleobase catabolic process (GO:0006208)3.67387998
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.65269092
55regulation of cellular amino acid metabolic process (GO:0006521)3.63253348
56protein deneddylation (GO:0000338)3.62959404
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61736286
587-methylguanosine mRNA capping (GO:0006370)3.61387804
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60841905
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.59814817
61ATP hydrolysis coupled proton transport (GO:0015991)3.59814817
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57061719
63postsynaptic membrane organization (GO:0001941)3.55485975
64respiratory electron transport chain (GO:0022904)3.55092115
65DNA damage response, detection of DNA damage (GO:0042769)3.53070357
66pseudouridine synthesis (GO:0001522)3.52529204
677-methylguanosine RNA capping (GO:0009452)3.51700610
68RNA capping (GO:0036260)3.51700610
69histone mRNA metabolic process (GO:0008334)3.51653957
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51614363
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.51062874
72termination of RNA polymerase III transcription (GO:0006386)3.50424511
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.50424511
74DNA strand elongation involved in DNA replication (GO:0006271)3.49365661
75electron transport chain (GO:0022900)3.48844513
76cellular component biogenesis (GO:0044085)3.46695531
77establishment of mitochondrion localization (GO:0051654)3.45035272
78DNA replication initiation (GO:0006270)3.44023430
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43672885
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41576311
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41576311
82chaperone-mediated protein transport (GO:0072321)3.39186831
83positive regulation of mitochondrial fission (GO:0090141)3.38953307
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36769210
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36769210
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36769210
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35368885
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33633127
89protein targeting to mitochondrion (GO:0006626)3.33568231
90metallo-sulfur cluster assembly (GO:0031163)3.33264847
91iron-sulfur cluster assembly (GO:0016226)3.33264847
92signal transduction involved in DNA damage checkpoint (GO:0072422)3.32694100
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32694100
942-deoxyribonucleotide biosynthetic process (GO:0009265)3.32673868
95deoxyribose phosphate biosynthetic process (GO:0046385)3.32673868
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.32555932
97respiratory chain complex IV assembly (GO:0008535)3.32300388
98protein-cofactor linkage (GO:0018065)3.31848314
99establishment of protein localization to mitochondrion (GO:0072655)3.30875341
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28471586
101establishment of integrated proviral latency (GO:0075713)3.24154151
102DNA strand elongation (GO:0022616)3.23092376
103nuclear-transcribed mRNA catabolic process (GO:0000956)3.23082787
104ribosome assembly (GO:0042255)3.22654658
105neuron cell-cell adhesion (GO:0007158)3.22176760
106base-excision repair, AP site formation (GO:0006285)3.17629147
107deoxyribonucleotide biosynthetic process (GO:0009263)3.15251154
108cytochrome complex assembly (GO:0017004)3.15032265
109positive regulation of ligase activity (GO:0051351)3.13925900
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13629927
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13629927
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13198365
113telomere maintenance via semi-conservative replication (GO:0032201)3.11927537
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11793973
115ATP synthesis coupled proton transport (GO:0015986)3.11793973
116protein neddylation (GO:0045116)3.11464082
117viral protein processing (GO:0019082)3.11239452
118regulation of mitochondrial translation (GO:0070129)3.10704980
119transcription-coupled nucleotide-excision repair (GO:0006283)3.10236472
120synaptic vesicle exocytosis (GO:0016079)3.09854215
121rRNA modification (GO:0000154)3.08568508
122nucleobase catabolic process (GO:0046113)3.08412278
123negative regulation of erythrocyte differentiation (GO:0045647)3.07297754
124mRNA catabolic process (GO:0006402)3.07242942
125mitotic nuclear envelope reassembly (GO:0007084)3.06322935
126nuclear envelope reassembly (GO:0031468)3.06322935
127protein localization to mitochondrion (GO:0070585)3.06220858
128mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03413600
129peptidyl-histidine modification (GO:0018202)3.00571850
130GDP-mannose metabolic process (GO:0019673)3.00398478
131negative regulation of B cell apoptotic process (GO:0002903)2.99194694
132spliceosomal tri-snRNP complex assembly (GO:0000244)2.96178811
133establishment of viral latency (GO:0019043)2.95156357
134positive regulation of TOR signaling (GO:0032008)2.94235559
135preassembly of GPI anchor in ER membrane (GO:0016254)2.89884472
136C-terminal protein lipidation (GO:0006501)2.89503345
137GMP metabolic process (GO:0046037)2.88514108
138protein maturation by protein folding (GO:0022417)2.84591399
139DNA integration (GO:0015074)2.84318911
140guanosine-containing compound biosynthetic process (GO:1901070)2.84010929
141regulation of cilium movement (GO:0003352)2.78422036
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75687545
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74499239
144C-terminal protein amino acid modification (GO:0018410)2.72255012
145mannosylation (GO:0097502)2.69643476
146hydrogen ion transmembrane transport (GO:1902600)2.67764703
147synaptic vesicle maturation (GO:0016188)2.65059038
148gamma-aminobutyric acid transport (GO:0015812)2.62536048
149de novo posttranslational protein folding (GO:0051084)2.62281489
150dicarboxylic acid catabolic process (GO:0043649)2.61859464
151tRNA aminoacylation for protein translation (GO:0006418)2.61605409
152gluconeogenesis (GO:0006094)2.60533121
153intracellular protein transmembrane import (GO:0044743)2.57981554
154L-methionine salvage (GO:0071267)2.55702215
155L-methionine biosynthetic process (GO:0071265)2.55702215
156amino acid salvage (GO:0043102)2.55702215
157ATP biosynthetic process (GO:0006754)2.55533921
158purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55075530
159presynaptic membrane assembly (GO:0097105)2.54313254
160purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.54282801
161heme biosynthetic process (GO:0006783)2.54109644
162mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.53780688
163fatty acid elongation (GO:0030497)2.53697835
164amino acid activation (GO:0043038)2.53061404
165tRNA aminoacylation (GO:0043039)2.53061404
166response to misfolded protein (GO:0051788)2.52673891
167GTP biosynthetic process (GO:0006183)2.50320923
168GPI anchor metabolic process (GO:0006505)2.49362247
169de novo protein folding (GO:0006458)2.48531096
170succinate metabolic process (GO:0006105)2.47899096
171glycosphingolipid biosynthetic process (GO:0006688)2.46875113
172neurotransmitter secretion (GO:0007269)2.46815956
173nonmotile primary cilium assembly (GO:0035058)2.45946513
174ribonucleoside triphosphate biosynthetic process (GO:0009201)2.45144790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.88708194
2E2F7_22180533_ChIP-Seq_HELA_Human4.08163991
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.06903894
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83866898
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76756604
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.59580141
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49987270
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.49342226
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.43603228
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.32854838
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.29581722
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28286258
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99825924
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.86498414
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84507065
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81827822
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69705496
18XRN2_22483619_ChIP-Seq_HELA_Human2.64503456
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57156970
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37793959
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.37058644
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30637609
23VDR_23849224_ChIP-Seq_CD4+_Human2.27677719
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23107143
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21731612
26* YY1_21170310_ChIP-Seq_MESCs_Mouse2.21212421
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20938859
28* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19966976
29DCP1A_22483619_ChIP-Seq_HELA_Human2.19685115
30GABP_19822575_ChIP-Seq_HepG2_Human2.04681632
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02519683
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.98164466
33TTF2_22483619_ChIP-Seq_HELA_Human1.97605459
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96082729
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.92247010
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83103774
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77269919
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76836814
39* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71308947
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.67626567
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67464785
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.66620179
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65096629
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61850590
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61709433
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58061560
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57379945
48MYC_18940864_ChIP-ChIP_HL60_Human1.57231397
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54553071
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54337356
51* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53741012
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53672149
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52694993
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48221721
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47852854
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46427779
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46425031
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46345453
59* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45706029
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45620546
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.43407531
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41540334
63CIITA_25753668_ChIP-Seq_RAJI_Human1.40881651
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.34783293
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33699072
66ZNF274_21170338_ChIP-Seq_K562_Hela1.31247969
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.29952593
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29780815
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28096747
70* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26776491
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26149179
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25993165
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24362625
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23322601
75* TET1_21451524_ChIP-Seq_MESCs_Mouse1.22035267
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20712853
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.17414926
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.15536799
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.14734936
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14383182
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12738684
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12630692
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11566934
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11333142
85P68_20966046_ChIP-Seq_HELA_Human1.09584133
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09067261
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09021677
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08305648
89VDR_21846776_ChIP-Seq_THP-1_Human1.08162694
90KDM5A_27292631_Chip-Seq_BREAST_Human1.07873709
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06593647
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06286198
93MYC_22102868_ChIP-Seq_BL_Human1.06219651
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00984168
95BCL6_27268052_Chip-Seq_Bcells_Human0.99508146
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99318212
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98818083
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98115557
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.97661978
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97406631
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.96051847
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95986162
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95816417
104* PHF8_20622854_ChIP-Seq_HELA_Human0.95611074
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95055326
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.94743424
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94633403
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94452513
109REST_21632747_ChIP-Seq_MESCs_Mouse0.93296215
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.93101622
111ZNF263_19887448_ChIP-Seq_K562_Human0.92977643
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92977088
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91678264
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91281715
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90883342
116* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90586741
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.89926984
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89671339
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89520552
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89194985
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87299302
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85951346
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85951346
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85951346
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85349051
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.84289419
127E2F1_20622854_ChIP-Seq_HELA_Human0.83468322
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83244598
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.82585361
130TP53_22573176_ChIP-Seq_HFKS_Human0.81138467
131CTCF_20526341_ChIP-Seq_ESCs_Human0.81003017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62679552
2MP0004957_abnormal_blastocyst_morpholog3.91322308
3MP0002822_catalepsy3.67927256
4MP0008932_abnormal_embryonic_tissue3.41647693
5MP0004270_analgesia2.81873016
6MP0003111_abnormal_nucleus_morphology2.81444608
7MP0005499_abnormal_olfactory_system2.67510739
8MP0005394_taste/olfaction_phenotype2.67510739
9MP0009379_abnormal_foot_pigmentation2.66163060
10MP0008789_abnormal_olfactory_epithelium2.64578900
11MP0003077_abnormal_cell_cycle2.62194382
12MP0003718_maternal_effect2.61572165
13MP0010094_abnormal_chromosome_stability2.54594935
14MP0004859_abnormal_synaptic_plasticity2.48251789
15MP0004142_abnormal_muscle_tone2.34864387
16MP0009333_abnormal_splenocyte_physiolog2.29750650
17MP0008995_early_reproductive_senescence2.27451077
18MP0003787_abnormal_imprinting2.22797215
19MP0003123_paternal_imprinting2.14678356
20MP0003122_maternal_imprinting2.00508434
21MP0002638_abnormal_pupillary_reflex2.00324086
22MP0001984_abnormal_olfaction1.86062374
23MP0003635_abnormal_synaptic_transmissio1.85919667
24MP0004147_increased_porphyrin_level1.83894262
25MP0006292_abnormal_olfactory_placode1.80459907
26MP0009745_abnormal_behavioral_response1.78979195
27MP0005645_abnormal_hypothalamus_physiol1.75817789
28MP0008058_abnormal_DNA_repair1.75210355
29MP0003315_abnormal_perineum_morphology1.70080373
30MP0002272_abnormal_nervous_system1.68974160
31MP0004133_heterotaxia1.65492908
32MP0001727_abnormal_embryo_implantation1.65323646
33MP0001730_embryonic_growth_arrest1.65087239
34MP0009046_muscle_twitch1.62959498
35MP0003938_abnormal_ear_development1.62188866
36MP0003890_abnormal_embryonic-extraembry1.59008748
37MP0002063_abnormal_learning/memory/cond1.58171558
38MP0001502_abnormal_circadian_rhythm1.57526870
39MP0000350_abnormal_cell_proliferation1.54996696
40MP0001529_abnormal_vocalization1.54056828
41MP0002572_abnormal_emotion/affect_behav1.52643637
42MP0002064_seizures1.52416977
43MP0008007_abnormal_cellular_replicative1.49236026
44MP0002734_abnormal_mechanical_nocicepti1.48131734
45MP0001986_abnormal_taste_sensitivity1.47975567
46MP0008260_abnormal_autophagy1.47536679
47MP0008877_abnormal_DNA_methylation1.44348962
48MP0003221_abnormal_cardiomyocyte_apopto1.42476718
49MP0005253_abnormal_eye_physiology1.41821592
50MP0003786_premature_aging1.38868313
51MP0002557_abnormal_social/conspecific_i1.38700754
52MP0001968_abnormal_touch/_nociception1.36196598
53MP0002933_joint_inflammation1.36048957
54MP0002160_abnormal_reproductive_system1.33856111
55MP0003806_abnormal_nucleotide_metabolis1.29106155
56MP0002751_abnormal_autonomic_nervous1.28799708
57MP0001764_abnormal_homeostasis1.28149932
58MP0000778_abnormal_nervous_system1.28097986
59MP0002132_abnormal_respiratory_system1.26814211
60MP0003763_abnormal_thymus_physiology1.26740039
61MP0004811_abnormal_neuron_physiology1.25544055
62MP0003880_abnormal_central_pattern1.23913431
63MP0005671_abnormal_response_to1.22127494
64MP0000313_abnormal_cell_death1.21559116
65MP0002733_abnormal_thermal_nociception1.19016060
66MP0001188_hyperpigmentation1.18190546
67MP0001697_abnormal_embryo_size1.18067639
68MP0005423_abnormal_somatic_nervous1.17664702
69MP0003136_yellow_coat_color1.16652084
70MP0009785_altered_susceptibility_to1.16006353
71MP0000049_abnormal_middle_ear1.15890758
72MP0004924_abnormal_behavior1.15570066
73MP0005386_behavior/neurological_phenoty1.15570066
74MP0003137_abnormal_impulse_conducting1.15214947
75MP0000703_abnormal_thymus_morphology1.12972307
76MP0002722_abnormal_immune_system1.12653545
77MP0006035_abnormal_mitochondrial_morpho1.12351839
78MP0006276_abnormal_autonomic_nervous1.10813244
79MP0002067_abnormal_sensory_capabilities1.09890859
80MP0001486_abnormal_startle_reflex1.09266495
81MP0000631_abnormal_neuroendocrine_gland1.08889688
82MP0002019_abnormal_tumor_incidence1.08885336
83MP0000689_abnormal_spleen_morphology1.08142173
84MP0002080_prenatal_lethality1.07814542
85MP0002398_abnormal_bone_marrow1.07422571
86MP0001905_abnormal_dopamine_level1.05522879
87MP0003119_abnormal_digestive_system1.05235332
88MP0000749_muscle_degeneration1.05174706
89MP0003011_delayed_dark_adaptation1.03948753
90MP0002653_abnormal_ependyma_morphology1.03357455
91MP0002210_abnormal_sex_determination1.03167800
92MP0002066_abnormal_motor_capabilities/c1.02867894
93MP0000490_abnormal_crypts_of1.02382904
94MP0002084_abnormal_developmental_patter1.02170551
95MP0002234_abnormal_pharynx_morphology1.02004777
96MP0002736_abnormal_nociception_after1.01044603
97MP0006072_abnormal_retinal_apoptosis1.00623783
98MP0002085_abnormal_embryonic_tissue1.00489602
99MP0002909_abnormal_adrenal_gland0.99874820
100MP0002837_dystrophic_cardiac_calcinosis0.98233350
101MP0001485_abnormal_pinna_reflex0.97948859
102MP0000358_abnormal_cell_content/0.97468302
103MP0002882_abnormal_neuron_morphology0.95703814
104MP0000955_abnormal_spinal_cord0.94113603
105MP0002102_abnormal_ear_morphology0.93812673
106MP0001819_abnormal_immune_cell0.93795186
107MP0004885_abnormal_endolymph0.93690137
108MP0001270_distended_abdomen0.93177419
109MP0002723_abnormal_immune_serum0.92982865
110MP0005646_abnormal_pituitary_gland0.92512661
111MP0000372_irregular_coat_pigmentation0.91252753
112MP0006036_abnormal_mitochondrial_physio0.90540791
113MP0005551_abnormal_eye_electrophysiolog0.90194729
114MP0002420_abnormal_adaptive_immunity0.89746249
115MP0002452_abnormal_antigen_presenting0.89261724
116MP0008057_abnormal_DNA_replication0.89215461
117MP0002429_abnormal_blood_cell0.88991618
118MP0005000_abnormal_immune_tolerance0.88458011
119MP0002069_abnormal_eating/drinking_beha0.88452704
120MP0000716_abnormal_immune_system0.88222040
121MP0002938_white_spotting0.88084092
122MP0001672_abnormal_embryogenesis/_devel0.87608544
123MP0005380_embryogenesis_phenotype0.87608544
124MP0000537_abnormal_urethra_morphology0.87427475
125MP0002396_abnormal_hematopoietic_system0.84562654
126MP0005389_reproductive_system_phenotype0.83773159
127MP0001853_heart_inflammation0.83612033
128MP0001145_abnormal_male_reproductive0.83541716
129MP0000858_altered_metastatic_potential0.83368830
130MP0005409_darkened_coat_color0.83297327
131MP0005025_abnormal_response_to0.82885728
132MP0000750_abnormal_muscle_regeneration0.82047189
133MP0004145_abnormal_muscle_electrophysio0.81157124
134MP0004742_abnormal_vestibular_system0.79979451
135MP0003329_amyloid_beta_deposits0.79675559
136MP0001800_abnormal_humoral_immune0.78581909
137MP0003656_abnormal_erythrocyte_physiolo0.78512008
138MP0006082_CNS_inflammation0.75779430
139MP0002277_abnormal_respiratory_mucosa0.75209735
140MP0001919_abnormal_reproductive_system0.74889341
141MP0002152_abnormal_brain_morphology0.74096392
142MP0003186_abnormal_redox_activity0.73996870
143MP0002163_abnormal_gland_morphology0.73877785
144MP0005535_abnormal_body_temperature0.72122514
145MP0002752_abnormal_somatic_nervous0.72029273
146MP0005332_abnormal_amino_acid0.71963874
147MP0000920_abnormal_myelination0.71912792
148MP0008569_lethality_at_weaning0.71700711
149MP0002229_neurodegeneration0.71639547
150MP0002735_abnormal_chemical_nociception0.71636321
151MP0000751_myopathy0.71329171
152MP0000026_abnormal_inner_ear0.68829559
153MP0005075_abnormal_melanosome_morpholog0.68600576
154MP0010030_abnormal_orbit_morphology0.68342541
155MP0002184_abnormal_innervation0.66933041
156MP0001970_abnormal_pain_threshold0.65492924
157MP0009840_abnormal_foam_cell0.64266705
158MP0002169_no_abnormal_phenotype0.64168049
159MP0003121_genomic_imprinting0.64031140

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.45076264
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35650972
3Abnormal number of erythroid precursors (HP:0012131)4.52379569
4Aplastic anemia (HP:0001915)4.45431227
5Hepatic necrosis (HP:0002605)4.23903228
6Mitochondrial inheritance (HP:0001427)4.21293910
7Cerebral hypomyelination (HP:0006808)4.13913234
8Reticulocytopenia (HP:0001896)4.10011065
9Cholecystitis (HP:0001082)3.83078628
10Abnormal gallbladder physiology (HP:0012438)3.83078628
11Patellar aplasia (HP:0006443)3.79804086
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72110928
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72110928
14Macrocytic anemia (HP:0001972)3.70482135
15Capillary hemangiomas (HP:0005306)3.70095501
16Breast hypoplasia (HP:0003187)3.66107369
17Emotional lability (HP:0000712)3.61123667
18Aplasia/Hypoplasia of the patella (HP:0006498)3.58315621
19Birth length less than 3rd percentile (HP:0003561)3.56454730
20Increased CSF lactate (HP:0002490)3.54326780
21Pallor (HP:0000980)3.46294087
22Oral leukoplakia (HP:0002745)3.37058650
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.22118125
24Retinal dysplasia (HP:0007973)3.20146850
25Increased serum lactate (HP:0002151)3.11931814
26Polyphagia (HP:0002591)3.06115608
27Rough bone trabeculation (HP:0100670)2.98032879
28Cerebral edema (HP:0002181)2.96934313
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93945222
30Renal Fanconi syndrome (HP:0001994)2.92138327
31Acute necrotizing encephalopathy (HP:0006965)2.87635944
32CNS demyelination (HP:0007305)2.86028063
33Progressive muscle weakness (HP:0003323)2.84770669
34Respiratory failure (HP:0002878)2.84552434
35Absent thumb (HP:0009777)2.81865407
36Myokymia (HP:0002411)2.80057304
37Abnormal number of incisors (HP:0011064)2.76604624
38Increased hepatocellular lipid droplets (HP:0006565)2.71355649
39Premature graying of hair (HP:0002216)2.67868829
40Abnormal mitochondria in muscle tissue (HP:0008316)2.67062108
41Severe visual impairment (HP:0001141)2.65945723
42Muscle fiber atrophy (HP:0100295)2.64327106
43Increased muscle lipid content (HP:0009058)2.63849862
44Neuroendocrine neoplasm (HP:0100634)2.63002671
45Type 2 muscle fiber atrophy (HP:0003554)2.58828512
46Postnatal microcephaly (HP:0005484)2.56554850
47Gait imbalance (HP:0002141)2.53988953
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53979190
49Progressive microcephaly (HP:0000253)2.49160816
50Carpal bone hypoplasia (HP:0001498)2.46327831
513-Methylglutaconic aciduria (HP:0003535)2.44606053
52Cholelithiasis (HP:0001081)2.43434598
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42194972
54Microvesicular hepatic steatosis (HP:0001414)2.39705485
55Medulloblastoma (HP:0002885)2.37550851
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.36634849
57Failure to thrive in infancy (HP:0001531)2.35493689
58Abnormal gallbladder morphology (HP:0012437)2.35444671
59Abnormality of the labia minora (HP:0012880)2.34451888
60Aqueductal stenosis (HP:0002410)2.33186914
61Lactic acidosis (HP:0003128)2.31505944
62Medial flaring of the eyebrow (HP:0010747)2.30392161
63Ankle clonus (HP:0011448)2.30368992
64Congenital primary aphakia (HP:0007707)2.30299466
65Facial diplegia (HP:0001349)2.30269723
66Hypoplasia of the radius (HP:0002984)2.30106302
67CNS hypomyelination (HP:0003429)2.28638121
68Pheochromocytoma (HP:0002666)2.27441925
69Abnormal sex determination (HP:0012244)2.26474110
70Sex reversal (HP:0012245)2.26474110
71Progressive external ophthalmoplegia (HP:0000590)2.25040022
72Hypertensive crisis (HP:0100735)2.23515808
73Nephrogenic diabetes insipidus (HP:0009806)2.22536011
74Cortical dysplasia (HP:0002539)2.21705872
75Increased IgM level (HP:0003496)2.21483989
76Delusions (HP:0000746)2.20743464
77Leukodystrophy (HP:0002415)2.20374263
78Triphalangeal thumb (HP:0001199)2.19008452
79Horseshoe kidney (HP:0000085)2.18906803
80Lipid accumulation in hepatocytes (HP:0006561)2.15535726
81Exercise intolerance (HP:0003546)2.14704301
82Hemiparesis (HP:0001269)2.14572682
83Respiratory difficulties (HP:0002880)2.12249231
84Increased serum pyruvate (HP:0003542)2.08418984
85Abnormality of glycolysis (HP:0004366)2.08418984
86Absent radius (HP:0003974)2.08120029
87Neoplasm of the peripheral nervous system (HP:0100007)2.07670473
88Degeneration of anterior horn cells (HP:0002398)2.06197054
89Abnormality of the anterior horn cell (HP:0006802)2.06197054
90Muscular hypotonia of the trunk (HP:0008936)2.05986781
91Nuclear cataract (HP:0100018)2.05884443
92Slow-growing hair (HP:0002217)2.05785179
93Abnormality of hair growth rate (HP:0011363)2.05785179
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05604086
95Premature ovarian failure (HP:0008209)2.05384080
96Pancytopenia (HP:0001876)2.04819687
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03918834
98Abnormal trabecular bone morphology (HP:0100671)2.03277615
99Lissencephaly (HP:0001339)2.01123457
100Progressive macrocephaly (HP:0004481)2.01106094
101Ketoacidosis (HP:0001993)2.00195533
102Testicular atrophy (HP:0000029)1.99250997
103Increased intramyocellular lipid droplets (HP:0012240)1.97684873
104Aplasia involving forearm bones (HP:0009822)1.97387479
105Absent forearm bone (HP:0003953)1.97387479
106Agitation (HP:0000713)1.96702945
107Methylmalonic aciduria (HP:0012120)1.95839067
108Thick lower lip vermilion (HP:0000179)1.95479977
109Abnormal glycosylation (HP:0012345)1.94650977
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94650977
111Abnormal protein N-linked glycosylation (HP:0012347)1.94650977
112Abnormal protein glycosylation (HP:0012346)1.94650977
113Selective tooth agenesis (HP:0001592)1.94218238
114Type I transferrin isoform profile (HP:0003642)1.93872625
115Rimmed vacuoles (HP:0003805)1.93849356
116Hypsarrhythmia (HP:0002521)1.93725285
117Ketosis (HP:0001946)1.93395401
118Stenosis of the external auditory canal (HP:0000402)1.93180612
119Secondary amenorrhea (HP:0000869)1.91690822
120Abnormality of the intervertebral disk (HP:0005108)1.91494369
121Neoplasm of the pancreas (HP:0002894)1.89638422
122Cleft eyelid (HP:0000625)1.87729100
123EEG with generalized epileptiform discharges (HP:0011198)1.87493579
124Gliosis (HP:0002171)1.87140810
125Methylmalonic acidemia (HP:0002912)1.86633855
126Absent speech (HP:0001344)1.86406184
127Lethargy (HP:0001254)1.85780284
128Acute encephalopathy (HP:0006846)1.84559665
129Hypoplasia of the brainstem (HP:0002365)1.84447530
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84447530
131Generalized hypotonia (HP:0001290)1.83991072
132Shoulder girdle muscle weakness (HP:0003547)1.83562849
133Dicarboxylic aciduria (HP:0003215)1.83243687
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83243687
135Exertional dyspnea (HP:0002875)1.82849731
136Epileptiform EEG discharges (HP:0011182)1.82066979
137Abnormality of the gallbladder (HP:0005264)1.79657612
138Optic disc pallor (HP:0000543)1.79191770
139Trismus (HP:0000211)1.78326886
140X-linked dominant inheritance (HP:0001423)1.77664100
141Poor suck (HP:0002033)1.75655706
142Depressed nasal ridge (HP:0000457)1.75522708
143Abnormality of the preputium (HP:0100587)1.74016368
144Meckel diverticulum (HP:0002245)1.73947052
145Ragged-red muscle fibers (HP:0003200)1.73559765
146Focal motor seizures (HP:0011153)1.73138602
147Tracheoesophageal fistula (HP:0002575)1.72715489
148Severe muscular hypotonia (HP:0006829)1.72612449
149Supranuclear gaze palsy (HP:0000605)1.71933857
150Type II lissencephaly (HP:0007260)1.71888345
151Abdominal situs inversus (HP:0003363)1.71261405
152Abnormality of abdominal situs (HP:0011620)1.71261405
153Spastic gait (HP:0002064)1.71030317
154Atrophy/Degeneration involving motor neurons (HP:0007373)1.70983361
155Hypoplastic pelvis (HP:0008839)1.67844079
156Hyperglycinemia (HP:0002154)1.67139161
157Epileptic encephalopathy (HP:0200134)1.65805544
158Generalized aminoaciduria (HP:0002909)1.65108634
159Pachygyria (HP:0001302)1.64800624
160Abnormality of the metopic suture (HP:0005556)1.60990230
161Spastic tetraplegia (HP:0002510)1.60752042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.60124113
2NME24.24570302
3ACVR1B4.04843383
4STK163.78156452
5BUB13.62166916
6MAP4K23.35849541
7NEK13.32121446
8MAP3K123.25659274
9MARK13.23026898
10TLK13.00119833
11MAP2K72.86669835
12LIMK12.79590345
13TESK22.78169305
14WEE12.74276354
15MAP3K42.58574017
16CCNB12.55022912
17NME12.37919313
18SRPK12.36755102
19EIF2AK12.25611864
20TRIM282.20874346
21MAP3K112.18917074
22MKNK22.05687489
23TSSK61.96847951
24BRAF1.86382098
25WNK31.86128007
26PNCK1.85997373
27PINK11.80502146
28MKNK11.80085619
29PIM21.79840979
30MUSK1.75984130
31PHKG21.66967973
32PHKG11.66967973
33PAK61.63462200
34TGFBR11.61579308
35PRKD31.54762008
36BMPR1B1.51856091
37EIF2AK31.49280128
38CDK191.48542976
39ARAF1.46946051
40MAP2K41.45644710
41ALK1.44770496
42CDC71.36542881
43MAPK131.33021630
44PDK21.32922131
45DYRK21.32540321
46WNK11.28573827
47CSNK1A1L1.28012622
48PAK31.27391765
49CSNK1G21.24887590
50DAPK11.22243691
51AURKA1.16469348
52CASK1.15985768
53TNIK1.15176532
54VRK11.12526527
55SIK31.11165960
56PLK11.06647879
57CHEK21.06208723
58SIK21.06151207
59ABL21.00141588
60CDK70.99286865
61BLK0.98906005
62TESK10.97409141
63CSNK1G10.94367625
64ZAK0.92540644
65KDR0.92174521
66TNK20.91021316
67TAOK20.88276650
68RPS6KA40.88209814
69PRKCG0.85985087
70PBK0.85146805
71DAPK20.83958874
72RAF10.83298693
73DYRK1B0.80528857
74CDK80.78910920
75DYRK30.77096083
76UHMK10.76170054
77CDK50.76168244
78EPHA20.74232237
79CSNK2A20.73441854
80PAK10.73028608
81MAP3K80.71213719
82CSNK2A10.69244240
83MAPKAPK50.67768178
84EPHA40.67242197
85NTRK20.65102273
86NEK20.64489507
87DAPK30.62073028
88EPHA30.61822324
89DYRK1A0.61033291
90CSNK1G30.60088290
91CAMK2G0.59406462
92KSR10.58970621
93PKN10.58941889
94TTK0.57054625
95PLK30.56951783
96CHEK10.56640796
97NTRK30.55031878
98MINK10.54680419
99RPS6KA50.54043791
100PRKD20.54012526
101KSR20.52839211
102GRK10.52144208
103MAP2K60.51786892
104TAOK10.51068002
105AURKB0.51037570
106ILK0.50120679
107FGR0.49948557
108PLK40.48967530
109IRAK20.47535461
110PRKCZ0.45509478
111PRPF4B0.45087438
112CDK11A0.44883281
113PASK0.44573087
114CDK140.44445124
115CAMK2B0.43246740
116PRKCI0.43180939
117BCR0.42491876
118BRSK20.40228342
119CAMK2D0.39466364
120MELK0.38476102
121LYN0.38431309
122BMX0.37636025
123INSRR0.36662008
124LATS20.36581487
125BCKDK0.36446694
126RIPK40.36310046
127PAK40.35796644
128LMTK20.35713432
129BRSK10.35042359
130MAP4K10.34653458
131ATR0.34478032
132BRD40.33584514
133SYK0.32884184
134CDK150.32714415
135CDK180.32623499
136AKT20.32342641
137IRAK40.31304698
138LCK0.31266329
139EIF2AK20.30617166
140PRKD10.29559125
141ADRBK10.29488083
142CDK20.29174862
143CSNK1E0.28555421
144CSNK1A10.28234093
145PRKACB0.28058135
146TBK10.27957517
147CDC42BPA0.27512664
148IRAK30.27153543
149MAPK90.26591279
150PRKACA0.26309740
151ZAP700.24741192
152IKBKB0.23166819

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.23231229
2Proteasome_Homo sapiens_hsa030504.80416952
3RNA polymerase_Homo sapiens_hsa030203.95134138
4DNA replication_Homo sapiens_hsa030303.30804417
5Spliceosome_Homo sapiens_hsa030403.26205997
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24077176
7Oxidative phosphorylation_Homo sapiens_hsa001902.77114254
8Mismatch repair_Homo sapiens_hsa034302.74389948
9Parkinsons disease_Homo sapiens_hsa050122.59987317
10RNA transport_Homo sapiens_hsa030132.42393821
11Pyrimidine metabolism_Homo sapiens_hsa002402.40794838
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35582112
13Nucleotide excision repair_Homo sapiens_hsa034202.31660247
14Protein export_Homo sapiens_hsa030602.18082987
15Sulfur relay system_Homo sapiens_hsa041222.15415862
16Basal transcription factors_Homo sapiens_hsa030222.07914664
17Huntingtons disease_Homo sapiens_hsa050162.07212139
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03401392
19Homologous recombination_Homo sapiens_hsa034401.98570716
20Base excision repair_Homo sapiens_hsa034101.86843148
21Nicotine addiction_Homo sapiens_hsa050331.86559751
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78253316
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72410649
24Alzheimers disease_Homo sapiens_hsa050101.63663310
25Cell cycle_Homo sapiens_hsa041101.60001964
26Folate biosynthesis_Homo sapiens_hsa007901.54516674
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47747525
28Epstein-Barr virus infection_Homo sapiens_hsa051691.44017764
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41568552
30RNA degradation_Homo sapiens_hsa030181.40022761
31Sulfur metabolism_Homo sapiens_hsa009201.39308609
32Fructose and mannose metabolism_Homo sapiens_hsa000511.38316022
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38257866
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36353079
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35175464
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35033904
37GABAergic synapse_Homo sapiens_hsa047271.32627286
38Fanconi anemia pathway_Homo sapiens_hsa034601.32058862
39Butanoate metabolism_Homo sapiens_hsa006501.25643603
40Purine metabolism_Homo sapiens_hsa002301.25331292
41One carbon pool by folate_Homo sapiens_hsa006701.21202229
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19101779
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14949937
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13778846
45Cardiac muscle contraction_Homo sapiens_hsa042601.05069149
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03896733
47Primary immunodeficiency_Homo sapiens_hsa053401.03357467
48mRNA surveillance pathway_Homo sapiens_hsa030150.98923385
49Steroid biosynthesis_Homo sapiens_hsa001000.97625678
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91013269
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89686951
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89493261
53Peroxisome_Homo sapiens_hsa041460.87824574
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86923670
55p53 signaling pathway_Homo sapiens_hsa041150.79282001
56Fatty acid metabolism_Homo sapiens_hsa012120.79236862
57Herpes simplex infection_Homo sapiens_hsa051680.78624785
58Oocyte meiosis_Homo sapiens_hsa041140.78014417
59Glutathione metabolism_Homo sapiens_hsa004800.77690428
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76059915
61Systemic lupus erythematosus_Homo sapiens_hsa053220.74713761
62Pyruvate metabolism_Homo sapiens_hsa006200.74068251
63Vibrio cholerae infection_Homo sapiens_hsa051100.70804461
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70576728
65Dopaminergic synapse_Homo sapiens_hsa047280.70421925
66Circadian rhythm_Homo sapiens_hsa047100.68290339
67Amphetamine addiction_Homo sapiens_hsa050310.67945396
68Propanoate metabolism_Homo sapiens_hsa006400.66515147
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65940224
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65390874
71Thyroid cancer_Homo sapiens_hsa052160.65013072
72Antigen processing and presentation_Homo sapiens_hsa046120.63776905
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60804012
74Asthma_Homo sapiens_hsa053100.59323056
75Morphine addiction_Homo sapiens_hsa050320.59083026
76Glutamatergic synapse_Homo sapiens_hsa047240.57309012
77Pentose phosphate pathway_Homo sapiens_hsa000300.56376966
78Allograft rejection_Homo sapiens_hsa053300.56271022
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55543488
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55089086
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.53978642
82Alcoholism_Homo sapiens_hsa050340.53171204
83Measles_Homo sapiens_hsa051620.52400720
84Insulin secretion_Homo sapiens_hsa049110.52239823
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50561111
86Cocaine addiction_Homo sapiens_hsa050300.50421731
87Ether lipid metabolism_Homo sapiens_hsa005650.50333702
88Circadian entrainment_Homo sapiens_hsa047130.50290873
89N-Glycan biosynthesis_Homo sapiens_hsa005100.49688616
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49219471
91Viral carcinogenesis_Homo sapiens_hsa052030.48853694
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.47023569
93Graft-versus-host disease_Homo sapiens_hsa053320.46938123
94Vitamin B6 metabolism_Homo sapiens_hsa007500.46559392
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46475763
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44847690
97Acute myeloid leukemia_Homo sapiens_hsa052210.41488094
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41103876
99Regulation of autophagy_Homo sapiens_hsa041400.39037400
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38063861
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37942822
102Non-homologous end-joining_Homo sapiens_hsa034500.37272188
103T cell receptor signaling pathway_Homo sapiens_hsa046600.37034879
104HTLV-I infection_Homo sapiens_hsa051660.36416123
105Hematopoietic cell lineage_Homo sapiens_hsa046400.35724580
106Taste transduction_Homo sapiens_hsa047420.35530891
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34898117
108Phototransduction_Homo sapiens_hsa047440.34283957
109Arginine biosynthesis_Homo sapiens_hsa002200.34239989
110Metabolic pathways_Homo sapiens_hsa011000.33179803
111beta-Alanine metabolism_Homo sapiens_hsa004100.32352965
112Biosynthesis of amino acids_Homo sapiens_hsa012300.31468878
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30865686
114Legionellosis_Homo sapiens_hsa051340.30143652
115Type I diabetes mellitus_Homo sapiens_hsa049400.28050283
116Autoimmune thyroid disease_Homo sapiens_hsa053200.26850720
117Shigellosis_Homo sapiens_hsa051310.26574610
118Viral myocarditis_Homo sapiens_hsa054160.25577862
119B cell receptor signaling pathway_Homo sapiens_hsa046620.25237845
120Arginine and proline metabolism_Homo sapiens_hsa003300.24861695
121Apoptosis_Homo sapiens_hsa042100.22293009
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21714367
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.20792432
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19849571
125Collecting duct acid secretion_Homo sapiens_hsa049660.19835738
126Renal cell carcinoma_Homo sapiens_hsa052110.19675952
127Glucagon signaling pathway_Homo sapiens_hsa049220.18781052
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17898211
129HIF-1 signaling pathway_Homo sapiens_hsa040660.17218670
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.16824804
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16346019
132Hepatitis B_Homo sapiens_hsa051610.15953019
133Fatty acid elongation_Homo sapiens_hsa000620.15926277
134Phagosome_Homo sapiens_hsa041450.15283816
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15215473
136Hepatitis C_Homo sapiens_hsa051600.12731113
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11078331
138Sphingolipid metabolism_Homo sapiens_hsa006000.10704658
139Colorectal cancer_Homo sapiens_hsa052100.10404806
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.09949045
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09143593
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08976044
143Arachidonic acid metabolism_Homo sapiens_hsa005900.08850880
144Synaptic vesicle cycle_Homo sapiens_hsa047210.07955296
145Prion diseases_Homo sapiens_hsa050200.07556762
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07522967
147Carbon metabolism_Homo sapiens_hsa012000.07360533

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