DHRS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.34260230
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.34260230
3L-phenylalanine metabolic process (GO:0006558)6.06576265
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.06576265
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.41870408
6aromatic amino acid family catabolic process (GO:0009074)5.36265543
7alpha-linolenic acid metabolic process (GO:0036109)4.94257869
8glyoxylate metabolic process (GO:0046487)4.92827631
9epoxygenase P450 pathway (GO:0019373)4.78767527
10bile acid biosynthetic process (GO:0006699)4.77726452
11cysteine metabolic process (GO:0006534)4.68111461
12high-density lipoprotein particle remodeling (GO:0034375)4.61595057
13indolalkylamine catabolic process (GO:0046218)4.53159823
14tryptophan catabolic process (GO:0006569)4.53159823
15indole-containing compound catabolic process (GO:0042436)4.53159823
16regulation of cholesterol esterification (GO:0010872)4.50537202
17alkaloid metabolic process (GO:0009820)4.48053847
18sulfur amino acid catabolic process (GO:0000098)4.45622424
19coenzyme catabolic process (GO:0009109)4.38726084
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34339531
21kynurenine metabolic process (GO:0070189)4.31610199
22urea metabolic process (GO:0019627)4.31472526
23urea cycle (GO:0000050)4.31472526
24reverse cholesterol transport (GO:0043691)4.27097801
25tryptophan metabolic process (GO:0006568)4.27091657
26omega-hydroxylase P450 pathway (GO:0097267)4.24285500
27cellular ketone body metabolic process (GO:0046950)4.18849472
28regulation of triglyceride catabolic process (GO:0010896)4.17505576
29plasma lipoprotein particle remodeling (GO:0034369)4.06735927
30protein-lipid complex remodeling (GO:0034368)4.06735927
31macromolecular complex remodeling (GO:0034367)4.06735927
32phospholipid efflux (GO:0033700)4.03541645
33protein carboxylation (GO:0018214)4.02266229
34peptidyl-glutamic acid carboxylation (GO:0017187)4.02266229
35drug metabolic process (GO:0017144)4.00990572
36nitrogen cycle metabolic process (GO:0071941)4.00473376
37oxidative demethylation (GO:0070989)3.99811813
38negative regulation of fibrinolysis (GO:0051918)3.99229184
39bile acid metabolic process (GO:0008206)3.98255968
40lysine catabolic process (GO:0006554)3.93367044
41lysine metabolic process (GO:0006553)3.93367044
42aromatic amino acid family metabolic process (GO:0009072)3.87136973
43regulation of protein activation cascade (GO:2000257)3.86855108
44aldehyde catabolic process (GO:0046185)3.85448280
45regulation of fibrinolysis (GO:0051917)3.82244335
46homocysteine metabolic process (GO:0050667)3.80493073
47cholesterol efflux (GO:0033344)3.79584846
48tyrosine metabolic process (GO:0006570)3.79034919
49amino-acid betaine metabolic process (GO:0006577)3.78692642
50cofactor catabolic process (GO:0051187)3.77666709
51alpha-amino acid catabolic process (GO:1901606)3.77029022
52cellular glucuronidation (GO:0052695)3.71976502
53complement activation, alternative pathway (GO:0006957)3.70547298
54low-density lipoprotein particle remodeling (GO:0034374)3.69507578
55quinone biosynthetic process (GO:1901663)3.68672742
56glutamate metabolic process (GO:0006536)3.68415649
57negative regulation of cholesterol transport (GO:0032375)3.67594123
58negative regulation of sterol transport (GO:0032372)3.67594123
59drug catabolic process (GO:0042737)3.65767672
60regulation of complement activation (GO:0030449)3.63961426
61cellular modified amino acid catabolic process (GO:0042219)3.62882167
62intestinal cholesterol absorption (GO:0030299)3.62817145
63arginine catabolic process (GO:0006527)3.62113002
64ketone body metabolic process (GO:1902224)3.62007957
65serine family amino acid catabolic process (GO:0009071)3.60739059
66cellular amino acid catabolic process (GO:0009063)3.60226195
67glucuronate metabolic process (GO:0019585)3.54944451
68uronic acid metabolic process (GO:0006063)3.54944451
69very long-chain fatty acid metabolic process (GO:0000038)3.53737981
70aspartate family amino acid catabolic process (GO:0009068)3.52949510
71flavonoid metabolic process (GO:0009812)3.52784363
72arginine metabolic process (GO:0006525)3.46056053
73positive regulation of lipoprotein lipase activity (GO:0051006)3.42502972
74positive regulation of triglyceride lipase activity (GO:0061365)3.42502972
75plasma lipoprotein particle clearance (GO:0034381)3.42125455
76ethanol oxidation (GO:0006069)3.41751539
77triglyceride homeostasis (GO:0070328)3.40768071
78acylglycerol homeostasis (GO:0055090)3.40768071
79short-chain fatty acid metabolic process (GO:0046459)3.40090562
80platelet dense granule organization (GO:0060155)3.38385012
81plasma lipoprotein particle assembly (GO:0034377)3.33907376
82ubiquinone biosynthetic process (GO:0006744)3.32426243
83bile acid and bile salt transport (GO:0015721)3.30758913
84ethanol metabolic process (GO:0006067)3.29019610
85regulation of plasminogen activation (GO:0010755)3.28292288
86acetyl-CoA metabolic process (GO:0006084)3.27938217
87amine catabolic process (GO:0009310)3.26609548
88cellular biogenic amine catabolic process (GO:0042402)3.26609548
89serine family amino acid biosynthetic process (GO:0009070)3.26491486
90organic acid catabolic process (GO:0016054)3.25970266
91carboxylic acid catabolic process (GO:0046395)3.25970266
92blood coagulation, intrinsic pathway (GO:0007597)3.25746599
93quinone metabolic process (GO:1901661)3.24183831
94benzene-containing compound metabolic process (GO:0042537)3.24007265
95DNA deamination (GO:0045006)3.23604354
96response to nitrosative stress (GO:0051409)3.21904627
97S-adenosylmethionine metabolic process (GO:0046500)3.21188138
98serine family amino acid metabolic process (GO:0009069)3.21151020
99indolalkylamine metabolic process (GO:0006586)3.21022330
100drug transmembrane transport (GO:0006855)3.19831475
101fatty acid elongation (GO:0030497)3.18614637
102monocarboxylic acid catabolic process (GO:0072329)3.16800164
103exogenous drug catabolic process (GO:0042738)3.16655745
104purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.15926198
1053-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.15926198
106cholesterol homeostasis (GO:0042632)3.14211235
107negative regulation of protein activation cascade (GO:2000258)3.13936262
108very-low-density lipoprotein particle assembly (GO:0034379)3.13092340
109fatty acid catabolic process (GO:0009062)3.12464969
110regulation of cholesterol biosynthetic process (GO:0045540)3.10259671
111plasma lipoprotein particle organization (GO:0071827)3.09949341
112sterol homeostasis (GO:0055092)3.08325820
113regulation of cholesterol metabolic process (GO:0090181)3.07299186
114fibrinolysis (GO:0042730)3.06416986
115dicarboxylic acid catabolic process (GO:0043649)3.06370729
116fatty acid beta-oxidation (GO:0006635)3.06209622
117protein-lipid complex assembly (GO:0065005)3.05105960
118ubiquinone metabolic process (GO:0006743)3.03494500
119xenobiotic catabolic process (GO:0042178)3.01578869
120phenylpropanoid metabolic process (GO:0009698)2.99678606
121sulfation (GO:0051923)2.93517674
122behavioral response to nicotine (GO:0035095)2.85183937
123protein activation cascade (GO:0072376)2.84249221
124protein-cofactor linkage (GO:0018065)2.80584319
125regulation of humoral immune response (GO:0002920)2.76356190
126protein complex biogenesis (GO:0070271)2.74043718
127negative regulation of hemostasis (GO:1900047)2.72363925
128negative regulation of blood coagulation (GO:0030195)2.72363925
129xenobiotic metabolic process (GO:0006805)2.66100670
130imidazole-containing compound metabolic process (GO:0052803)2.64304584
131glycine metabolic process (GO:0006544)2.62443138
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62188857
133fat-soluble vitamin biosynthetic process (GO:0042362)2.62020168
134complement activation (GO:0006956)2.59793921
135negative regulation of coagulation (GO:0050819)2.59752436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.52141941
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.88993031
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.91262925
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.64467618
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.55277256
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.98058628
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96279952
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.94772687
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.58217039
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25265876
11ZNF274_21170338_ChIP-Seq_K562_Hela2.88040694
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68513343
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.58311128
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52042455
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33305264
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18547774
17VDR_22108803_ChIP-Seq_LS180_Human2.04681182
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91806646
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.80835982
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75841237
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71173930
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68845225
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67736485
24* SRF_21415370_ChIP-Seq_HL-1_Mouse1.66499458
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64439276
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62539873
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59168526
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.57053795
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56635612
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52636712
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52078717
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49653335
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.49653335
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49027630
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.46390789
36HTT_18923047_ChIP-ChIP_STHdh_Human1.45942783
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45214333
38BCL6_27268052_Chip-Seq_Bcells_Human1.44666480
39NANOG_20526341_ChIP-Seq_ESCs_Human1.44532386
40E2F1_20622854_ChIP-Seq_HELA_Human1.44194419
41MYC_19829295_ChIP-Seq_ESCs_Human1.41855464
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41003817
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38611302
44ERA_21632823_ChIP-Seq_H3396_Human1.36305189
45TAF15_26573619_Chip-Seq_HEK293_Human1.34281147
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31934268
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.30480118
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.28912837
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27677536
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27462175
51CTCF_20526341_ChIP-Seq_ESCs_Human1.26667199
52P300_27268052_Chip-Seq_Bcells_Human1.24621154
53STAT1_20625510_ChIP-Seq_HELA_Human1.24234077
54RAC3_21632823_ChIP-Seq_H3396_Human1.23781820
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.22319119
56CEBPB_22108803_ChIP-Seq_LS180_Human1.19852322
57* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19624057
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19556604
59P53_21459846_ChIP-Seq_SAOS-2_Human1.18659253
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18650201
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18650201
62IGF1R_20145208_ChIP-Seq_DFB_Human1.18614090
63BCOR_27268052_Chip-Seq_Bcells_Human1.18268904
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.15584553
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14640232
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13955427
67OCT4_20526341_ChIP-Seq_ESCs_Human1.13238224
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12162009
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.12063271
70IRF1_19129219_ChIP-ChIP_H3396_Human1.11652373
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11421757
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11098060
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09396158
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09145038
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08795404
76* GATA3_26560356_Chip-Seq_TH2_Human1.08452620
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06883323
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05579249
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.05075979
80GBX2_23144817_ChIP-Seq_PC3_Human1.04344669
81* VDR_23849224_ChIP-Seq_CD4+_Human1.03284397
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.02419697
83CLOCK_20551151_ChIP-Seq_293T_Human1.02411339
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01874631
85TP53_22573176_ChIP-Seq_HFKS_Human1.01350327
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01077610
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.00225967
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99878095
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99277043
90PHF8_20622854_ChIP-Seq_HELA_Human0.99110403
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98543128
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98240487
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97566744
94* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97289929
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96778079
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96128716
97ER_23166858_ChIP-Seq_MCF-7_Human0.96104652
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.95845920
99SA1_27219007_Chip-Seq_Bcells_Human0.95763422
100SOX2_21211035_ChIP-Seq_LN229_Human0.95137955
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93637079
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93337508
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91477575
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90390748
105BCAT_22108803_ChIP-Seq_LS180_Human0.90113114
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90106421
107SOX2_20726797_ChIP-Seq_SW620_Human0.89907568
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89548608
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88803397
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88403834
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88189747
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.86703183
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86208099
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.86072346
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.86027707
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84334113
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84000941
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83747884
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83172695
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82512217
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81764255
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81637066
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.81380495
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80577393
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78476550
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76933463
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76540688
128GATA4_25053715_ChIP-Seq_YYC3_Human0.76144607
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75507836
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74088551
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73582995
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71958405
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71937836
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.71269422
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70474823
136EGR1_19032775_ChIP-ChIP_M12_Human0.69398753
137* ERG_20517297_ChIP-Seq_VCAP_Human0.68427367
138SOX2_19829295_ChIP-Seq_ESCs_Human0.68211566
139NANOG_19829295_ChIP-Seq_ESCs_Human0.68211566
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.68183442
141EZH2_18974828_ChIP-Seq_MESCs_Mouse0.68183442
142MYC_19915707_ChIP-ChIP_AK7_Human0.67857016
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.67830960
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67287878
145P300_19829295_ChIP-Seq_ESCs_Human0.67101080
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66784754
147SUZ12_27294783_Chip-Seq_ESCs_Mouse0.66085611
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.65350836
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62178134
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61730307
151* AR_20517297_ChIP-Seq_VCAP_Human0.61612036
152TAF2_19829295_ChIP-Seq_ESCs_Human0.60488295
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.60314523
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.59980220
155* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59411728
156TP53_18474530_ChIP-ChIP_U2OS_Human0.59273832
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.59192759
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58901544
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58717828
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.58452751
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.58257613
162AR_21572438_ChIP-Seq_LNCaP_Human0.58132636
163CBP_21632823_ChIP-Seq_H3396_Human0.57687020
164AR_25329375_ChIP-Seq_VCAP_Human0.57589591
165NCOR_22424771_ChIP-Seq_293T_Human0.57506995
166CTCF_27219007_Chip-Seq_Bcells_Human0.57361384
167FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57048391
168SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56540179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.06534745
2MP0002139_abnormal_hepatobiliary_system6.89051690
3MP0005085_abnormal_gallbladder_physiolo5.16813178
4MP0005365_abnormal_bile_salt5.07151725
5MP0008875_abnormal_xenobiotic_pharmacok4.72007074
6MP0003806_abnormal_nucleotide_metabolis4.00932558
7MP0009840_abnormal_foam_cell3.26912283
8MP0010329_abnormal_lipoprotein_level3.07601830
9MP0003252_abnormal_bile_duct3.04466257
10MP0001666_abnormal_nutrient_absorption2.95578579
11MP0005083_abnormal_biliary_tract2.84802987
12MP0005332_abnormal_amino_acid2.81388131
13MP0003195_calcinosis2.41519022
14MP0004019_abnormal_vitamin_homeostasis2.09696439
15MP0003191_abnormal_cellular_cholesterol2.04827848
16MP0002118_abnormal_lipid_homeostasis1.93067498
17MP0003011_delayed_dark_adaptation1.84409434
18MP0005584_abnormal_enzyme/coenzyme_acti1.68170005
19MP0005451_abnormal_body_composition1.63302953
20MP0003329_amyloid_beta_deposits1.62072029
21MP0003690_abnormal_glial_cell1.59180350
22MP0000609_abnormal_liver_physiology1.58474603
23MP0003186_abnormal_redox_activity1.58433832
24MP0002138_abnormal_hepatobiliary_system1.56961691
25MP0000604_amyloidosis1.53785043
26MP0009697_abnormal_copulation1.52160801
27MP0002132_abnormal_respiratory_system1.50762934
28MP0003868_abnormal_feces_composition1.49030944
29MP0005319_abnormal_enzyme/_coenzyme1.48694747
30MP0001764_abnormal_homeostasis1.40170273
31MP0009785_altered_susceptibility_to1.38707136
32MP0005551_abnormal_eye_electrophysiolog1.31291063
33MP0009643_abnormal_urine_homeostasis1.29409613
34MP0003656_abnormal_erythrocyte_physiolo1.27592579
35MP0004858_abnormal_nervous_system1.24568604
36MP0006082_CNS_inflammation1.24143373
37MP0005084_abnormal_gallbladder_morpholo1.24012952
38MP0002876_abnormal_thyroid_physiology1.23094421
39MP0002653_abnormal_ependyma_morphology1.21339046
40MP0005377_hearing/vestibular/ear_phenot1.17619252
41MP0003878_abnormal_ear_physiology1.17619252
42MP0005670_abnormal_white_adipose1.16920045
43MP0005636_abnormal_mineral_homeostasis1.16904869
44MP0008995_early_reproductive_senescence1.16052404
45MP0000685_abnormal_immune_system1.15764138
46MP0005671_abnormal_response_to1.13754224
47MP0001873_stomach_inflammation1.11351366
48MP0003724_increased_susceptibility_to1.08226664
49MP0006036_abnormal_mitochondrial_physio1.06100853
50MP0001800_abnormal_humoral_immune1.06054731
51MP0001835_abnormal_antigen_presentation1.05928697
52MP0002822_catalepsy1.05698402
53MP0002736_abnormal_nociception_after1.01897333
54MP0009764_decreased_sensitivity_to1.01562694
55MP0004142_abnormal_muscle_tone1.00125252
56MP0006054_spinal_hemorrhage0.99565118
57MP0002234_abnormal_pharynx_morphology0.96780771
58MP0000516_abnormal_urinary_system0.95223901
59MP0005367_renal/urinary_system_phenotyp0.95223901
60MP0000427_abnormal_hair_cycle0.94085085
61MP0000920_abnormal_myelination0.92980628
62MP0005025_abnormal_response_to0.92871766
63MP0003436_decreased_susceptibility_to0.91413544
64MP0002148_abnormal_hypersensitivity_rea0.91341326
65MP0002254_reproductive_system_inflammat0.89076086
66MP0005408_hypopigmentation0.88988507
67MP0005647_abnormal_sex_gland0.88468681
68MP0009333_abnormal_splenocyte_physiolog0.86779005
69MP0005387_immune_system_phenotype0.84254950
70MP0001790_abnormal_immune_system0.84254950
71MP0005645_abnormal_hypothalamus_physiol0.83803815
72MP0002837_dystrophic_cardiac_calcinosis0.83561489
73MP0002735_abnormal_chemical_nociception0.82824563
74MP0002638_abnormal_pupillary_reflex0.82331933
75MP0001968_abnormal_touch/_nociception0.82146627
76MP0005535_abnormal_body_temperature0.81826636
77MP0001845_abnormal_inflammatory_respons0.81414207
78MP0003172_abnormal_lysosome_physiology0.79398698
79MP0002419_abnormal_innate_immunity0.78856843
80MP0008872_abnormal_physiological_respon0.78718736
81MP0001984_abnormal_olfaction0.78223313
82MP0004043_abnormal_pH_regulation0.78022796
83MP0002723_abnormal_immune_serum0.76279220
84MP0004270_analgesia0.75663395
85MP0005410_abnormal_fertilization0.75489227
86MP0000598_abnormal_liver_morphology0.74911638
87MP0009642_abnormal_blood_homeostasis0.74828354
88MP0005646_abnormal_pituitary_gland0.74378954
89MP0001756_abnormal_urination0.74051238
90MP0010155_abnormal_intestine_physiology0.74043088
91MP0002452_abnormal_antigen_presenting0.73746397
92MP0004147_increased_porphyrin_level0.73524308
93MP0003075_altered_response_to0.69457102
94MP0002282_abnormal_trachea_morphology0.69149793
95MP0005000_abnormal_immune_tolerance0.68954283
96MP0005376_homeostasis/metabolism_phenot0.68573881
97MP0002933_joint_inflammation0.68371176
98MP0003638_abnormal_response/metabolism_0.68220963
99MP0005075_abnormal_melanosome_morpholog0.68102738
100MP0006292_abnormal_olfactory_placode0.67110547
101MP0005464_abnormal_platelet_physiology0.66042825
102MP0005448_abnormal_energy_balance0.65593927
103MP0001501_abnormal_sleep_pattern0.65454789
104MP0009763_increased_sensitivity_to0.64999567
105MP0005058_abnormal_lysosome_morphology0.64834734
106MP0001663_abnormal_digestive_system0.64647202
107MP0002078_abnormal_glucose_homeostasis0.64221088
108MP0001905_abnormal_dopamine_level0.63804886
109MP0005166_decreased_susceptibility_to0.63780950
110MP0009384_cardiac_valve_regurgitation0.63732409
111MP0000639_abnormal_adrenal_gland0.63292666
112MP0008469_abnormal_protein_level0.63144849
113MP0000372_irregular_coat_pigmentation0.62570724
114MP0009765_abnormal_xenobiotic_induced0.62362210
115MP0001529_abnormal_vocalization0.61699700
116MP0003633_abnormal_nervous_system0.61572631
117MP0008874_decreased_physiological_sensi0.61215654
118MP0003705_abnormal_hypodermis_morpholog0.59491379
119MP0002733_abnormal_thermal_nociception0.58989962
120MP0006276_abnormal_autonomic_nervous0.56739955
121MP0000538_abnormal_urinary_bladder0.55855888
122MP0002734_abnormal_mechanical_nocicepti0.54483255
123MP0002064_seizures0.54475804
124MP0004885_abnormal_endolymph0.54424085
125MP0006035_abnormal_mitochondrial_morpho0.54368760
126MP0005167_abnormal_blood-brain_barrier0.53663114
127MP0000230_abnormal_systemic_arterial0.53507006
128MP0009780_abnormal_chondrocyte_physiolo0.53046597
129MP0001986_abnormal_taste_sensitivity0.52609184
130MP0003631_nervous_system_phenotype0.52265039
131MP0001765_abnormal_ion_homeostasis0.52115808
132MP0003634_abnormal_glial_cell0.51693295
133MP0005334_abnormal_fat_pad0.51614901
134MP0002090_abnormal_vision0.50903331
135MP0003183_abnormal_peptide_metabolism0.50520332
136MP0002295_abnormal_pulmonary_circulatio0.49610137
137MP0005395_other_phenotype0.49177404
138MP0005165_increased_susceptibility_to0.48306509
139MP0004130_abnormal_muscle_cell0.47577713
140MP0002136_abnormal_kidney_physiology0.47447703
141MP0009745_abnormal_behavioral_response0.46161310
142MP0005220_abnormal_exocrine_pancreas0.46120784
143MP0003632_abnormal_nervous_system0.45752015
144MP0004883_abnormal_blood_vessel0.45204143

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.18287387
2Deep venous thrombosis (HP:0002625)5.67430506
3Intrahepatic cholestasis (HP:0001406)5.61537604
4Hypobetalipoproteinemia (HP:0003563)5.28256129
5Xanthomatosis (HP:0000991)5.18965032
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.97177861
7Prolonged partial thromboplastin time (HP:0003645)4.60242590
8Hyperlipoproteinemia (HP:0010980)4.31435073
9Hyperammonemia (HP:0001987)4.04909099
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.96118982
11Hypolipoproteinemia (HP:0010981)3.90283863
12Ketosis (HP:0001946)3.78794911
13Complement deficiency (HP:0004431)3.78696198
14Fat malabsorption (HP:0002630)3.72682883
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.58339717
16Abnormality of glycine metabolism (HP:0010895)3.58086178
17Abnormality of serine family amino acid metabolism (HP:0010894)3.58086178
18Hyperglycinuria (HP:0003108)3.54533917
19Hyperglycinemia (HP:0002154)3.48632144
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47426491
21Conjugated hyperbilirubinemia (HP:0002908)3.44902558
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.39402478
23Epidermoid cyst (HP:0200040)3.27109762
24Hypoalphalipoproteinemia (HP:0003233)3.26549311
25Abnormal gallbladder physiology (HP:0012438)3.24298124
26Cholecystitis (HP:0001082)3.24298124
27Abnormality of methionine metabolism (HP:0010901)3.23963807
28Abnormality of the common coagulation pathway (HP:0010990)3.14440911
29Cerebral edema (HP:0002181)3.13023818
30Abnormality of fatty-acid metabolism (HP:0004359)3.12077072
31Joint hemorrhage (HP:0005261)3.08735870
32Ketoacidosis (HP:0001993)3.07129538
33Hypoglycemic coma (HP:0001325)2.98879000
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91860139
35Steatorrhea (HP:0002570)2.90954421
36Abnormality of glycolysis (HP:0004366)2.89307103
37Increased serum pyruvate (HP:0003542)2.89307103
38Lethargy (HP:0001254)2.87112513
39Acute encephalopathy (HP:0006846)2.85068614
40Delayed CNS myelination (HP:0002188)2.84932824
41Glomerulonephritis (HP:0000099)2.78190646
42Metabolic acidosis (HP:0001942)2.77614266
43Abnormality of alanine metabolism (HP:0010916)2.76058615
44Hyperalaninemia (HP:0003348)2.76058615
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76058615
46Hypercholesterolemia (HP:0003124)2.71029858
47Gout (HP:0001997)2.69709610
48Hyperbilirubinemia (HP:0002904)2.67136938
49Abnormality of purine metabolism (HP:0004352)2.66097595
50Congenital, generalized hypertrichosis (HP:0004540)2.64842647
51Abnormality of complement system (HP:0005339)2.64668228
52Pancreatic cysts (HP:0001737)2.63315148
53True hermaphroditism (HP:0010459)2.62868145
54Abnormality of the intrinsic pathway (HP:0010989)2.56130624
55Dry hair (HP:0011359)2.53926308
56Abnormality of nucleobase metabolism (HP:0010932)2.53129078
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52941018
58Dicarboxylic aciduria (HP:0003215)2.52941018
59Sensorimotor neuropathy (HP:0007141)2.52368034
60Abnormal gallbladder morphology (HP:0012437)2.46661595
61Abnormality of serum amino acid levels (HP:0003112)2.45313476
62Congenital stationary night blindness (HP:0007642)2.44440798
63Vascular calcification (HP:0004934)2.43853571
64Cholelithiasis (HP:0001081)2.42645216
65Malnutrition (HP:0004395)2.41841715
66Elevated erythrocyte sedimentation rate (HP:0003565)2.41267870
67Nephritis (HP:0000123)2.38305086
68Systemic lupus erythematosus (HP:0002725)2.37147368
69Abnormal biliary tract physiology (HP:0012439)2.36161100
70Bile duct proliferation (HP:0001408)2.36161100
71Vomiting (HP:0002013)2.35585216
72Amyloidosis (HP:0011034)2.33016983
73Fair hair (HP:0002286)2.30250914
74Neurofibrillary tangles (HP:0002185)2.29723108
75Abnormal mitochondria in muscle tissue (HP:0008316)2.28998377
76Hepatic necrosis (HP:0002605)2.28101571
77Abnormality of pyrimidine metabolism (HP:0004353)2.27192044
78Molar tooth sign on MRI (HP:0002419)2.25882185
79Abnormality of midbrain morphology (HP:0002418)2.25882185
80Acute necrotizing encephalopathy (HP:0006965)2.25555689
81Acanthocytosis (HP:0001927)2.23411367
82Pancreatic fibrosis (HP:0100732)2.22040000
83Increased CSF lactate (HP:0002490)2.21003125
84Irritability (HP:0000737)2.18956211
85Pheochromocytoma (HP:0002666)2.18896992
86Gangrene (HP:0100758)2.18715289
87Glycosuria (HP:0003076)2.15611582
88Abnormality of urine glucose concentration (HP:0011016)2.15611582
89Cardiovascular calcification (HP:0011915)2.14731521
90Alkalosis (HP:0001948)2.14410733
91Pigmentary retinal degeneration (HP:0001146)2.13078974
92Progressive macrocephaly (HP:0004481)2.12899604
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12282902
94Spontaneous abortion (HP:0005268)2.10990292
95Hydroxyprolinuria (HP:0003080)2.09883912
96Abnormality of proline metabolism (HP:0010907)2.09883912
97Chronic hepatic failure (HP:0100626)2.07579416
98Hyperventilation (HP:0002883)2.07326721
99Generalized aminoaciduria (HP:0002909)2.06526694
100Neuroendocrine neoplasm (HP:0100634)2.06292225
101Axonal loss (HP:0003447)2.05571386
102Hyperphosphaturia (HP:0003109)2.05509694
103Abnormality of the gallbladder (HP:0005264)2.04698342
104Neonatal onset (HP:0003623)2.03770957
105Mesangial abnormality (HP:0001966)2.03512153
106Cerebral hemorrhage (HP:0001342)2.03466530
107Hepatocellular necrosis (HP:0001404)2.01209832
108Abnormal drinking behavior (HP:0030082)2.00543689
109Polydipsia (HP:0001959)2.00543689
110Pancreatitis (HP:0001733)2.00021766
111Reduced antithrombin III activity (HP:0001976)1.99016649
112Hypothermia (HP:0002045)1.96544516
113Abnormality of the renal cortex (HP:0011035)1.96189296
114Lactic acidosis (HP:0003128)1.95861599
115Recurrent gram-negative bacterial infections (HP:0005420)1.95059612
1163-Methylglutaconic aciduria (HP:0003535)1.94340739
117Opisthotonus (HP:0002179)1.94029879
118Abnormality of the prostate (HP:0008775)1.93907495
119Spastic paraparesis (HP:0002313)1.93480122
120Hemorrhage of the eye (HP:0011885)1.92117281
121Hepatocellular carcinoma (HP:0001402)1.90854868
122Gingival bleeding (HP:0000225)1.90601675
123Attenuation of retinal blood vessels (HP:0007843)1.88946697
124Brushfield spots (HP:0001088)1.87262840
125Spastic diplegia (HP:0001264)1.87248820
126Mitochondrial inheritance (HP:0001427)1.87043300
127Hypoglycemic seizures (HP:0002173)1.86960360
128Purpura (HP:0000979)1.86637658
129Late onset (HP:0003584)1.86110853
130Methylmalonic aciduria (HP:0012120)1.85791930
131Skin nodule (HP:0200036)1.85560943
132Increased IgM level (HP:0003496)1.84365538
133Oral leukoplakia (HP:0002745)1.84271010
134Abnormality of the axillary hair (HP:0100134)1.84054639
135Abnormality of secondary sexual hair (HP:0009888)1.84054639
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81486934
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81486934
138CNS demyelination (HP:0007305)1.81407921
139Abnormal rod and cone electroretinograms (HP:0008323)1.80891763
140Hyperuricemia (HP:0002149)1.80582502
141Increased purine levels (HP:0004368)1.80582502
142Myocardial infarction (HP:0001658)1.80469703
143Abnormal urine output (HP:0012590)1.80082053
144Hypophosphatemic rickets (HP:0004912)1.79535667
145Enlarged kidneys (HP:0000105)1.79143073
146Increased serum lactate (HP:0002151)1.78143397
147Cystic liver disease (HP:0006706)1.77835410
148Anorexia (HP:0002039)1.77520556
149Parakeratosis (HP:0001036)1.77028414
150Hypochromic anemia (HP:0001931)1.76435827
151Pustule (HP:0200039)1.75728806
152Stomatitis (HP:0010280)1.73513067
153Woolly hair (HP:0002224)1.72240015
154Methylmalonic acidemia (HP:0002912)1.72103641
155Pulmonary embolism (HP:0002204)1.69931547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.96907347
2TLK13.57994383
3MAP4K23.51881622
4VRK22.67844821
5LMTK22.60011350
6MAP4K12.49883581
7ERN12.44272399
8ERBB42.34973677
9MAP2K42.21438047
10STK392.14756674
11TXK2.13664549
12MAP3K122.05460515
13ARAF2.04660873
14CASK2.00261396
15SIK11.99765330
16OXSR11.93046625
17NUAK11.91650125
18PIK3CA1.91404153
19GRK11.89367075
20MST41.79605833
21ZAK1.79210149
22FGFR41.78686321
23MUSK1.77212522
24PDK31.69840997
25PDK41.69840997
26WNK41.68127163
27IKBKB1.67571437
28DAPK21.67153549
29NTRK11.56081181
30CAMKK21.54722722
31WNK31.50608505
32MYLK1.49850664
33CDK191.43027626
34EPHB11.39027567
35KDR1.35760357
36SGK4941.34685022
37SGK2231.34685022
38MST1R1.32790491
39LIMK11.31875388
40STK161.29522531
41NEK91.26173404
42ACVR1B1.21553144
43MAP2K71.21394491
44CAMK2G1.19917291
45SYK1.17764244
46TNK21.14554614
47GRK61.12565963
48TYK21.12547747
49MAP2K11.12132952
50TESK11.10943798
51PDK21.10640254
52INSRR1.10599287
53CSF1R1.08507883
54GRK51.07920154
55EPHA41.04994995
56KIT1.03763199
57ABL21.00688291
58MAP3K20.97473873
59KSR20.96383481
60MINK10.94534627
61MAP3K40.92757518
62PTK2B0.92620945
63ITK0.92545682
64PHKG20.91810515
65PHKG10.91810515
66MAPK130.91276201
67BCR0.91046393
68MAP3K110.90350162
69PIM20.89898229
70VRK10.89682373
71IKBKE0.88832072
72ROCK20.88340060
73DYRK20.87744856
74GRK70.86046716
75TRIB30.85000052
76PINK10.84826093
77RIPK40.84290789
78BMPR20.83883497
79FRK0.82332806
80EPHB20.81658702
81MET0.81552932
82SIK20.80263718
83PASK0.78873199
84JAK30.78245825
85CSNK1A1L0.77272974
86PRKCG0.77013666
87CAMKK10.76261424
88CAMK2A0.76101817
89CCNB10.75115617
90CAMK2B0.74179175
91RET0.73477710
92FGR0.72835338
93MAPK40.72584264
94LCK0.69101680
95LYN0.68965952
96CAMK2D0.68698543
97MAP2K20.68621197
98TESK20.68473160
99SGK20.67996087
100BMPR1B0.67705207
101PAK30.67551351
102PRKD30.67057594
103CSNK1G30.65803197
104PRKCZ0.65687593
105MAP2K60.65535810
106FGFR20.65477367
107TEC0.63516463
108ERBB20.63040125
109PRKCQ0.63001681
110EPHA20.61987723
111FER0.61545577
112EPHA30.60948488
113MAPK150.60722700
114PLK20.60454551
115MAPK120.60241792
116GSK3A0.60189421
117ADRBK10.59118561
118CSNK1G10.59012219
119NME10.58598769
120MAPK110.58542636
121TAOK30.58419179
122ZAP700.58013838
123CSNK1G20.57657147
124PTK20.57643455
125TBK10.57070378
126PRKCE0.56290271
127STK38L0.56178045
128MAPKAPK50.56051219
129PRKACG0.55723338
130MAPKAPK30.55330780
131ROCK10.54434252
132MAP3K70.54181088
133BLK0.53500963
134ADRBK20.53380060
135RPS6KA50.53142766
136PIK3CG0.51683987
137CHUK0.51021899
138PDPK10.50784248
139PRKACA0.50724080
140NTRK20.50241175
141SGK30.50077720
142MAP3K10.49707515
143PRKCI0.49687872
144BRAF0.49538371
145PRKG20.49472186
146PRKCA0.49366667
147MAP3K30.49272613
148PTK60.49072703
149MOS0.48922817
150IRAK40.48887668
151BTK0.47063781
152PRKAA20.46701916
153TGFBR20.46491376
154ABL10.42633677
155IGF1R0.40459279
156FES0.36113027

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.64791613
2Nitrogen metabolism_Homo sapiens_hsa009103.28749653
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06530420
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91947196
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73085298
6Arginine biosynthesis_Homo sapiens_hsa002202.51459615
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49843624
8Fatty acid degradation_Homo sapiens_hsa000712.37417671
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33729480
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24575752
11Butanoate metabolism_Homo sapiens_hsa006502.22527404
12Tryptophan metabolism_Homo sapiens_hsa003802.22371990
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21914824
14Propanoate metabolism_Homo sapiens_hsa006402.13165551
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10840555
16Peroxisome_Homo sapiens_hsa041462.01760898
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00840886
18Complement and coagulation cascades_Homo sapiens_hsa046102.00809421
19Sulfur metabolism_Homo sapiens_hsa009201.95246602
20Fatty acid metabolism_Homo sapiens_hsa012121.90375218
21Histidine metabolism_Homo sapiens_hsa003401.87867890
22Fatty acid elongation_Homo sapiens_hsa000621.86907598
23Pyruvate metabolism_Homo sapiens_hsa006201.85525850
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84770840
25Chemical carcinogenesis_Homo sapiens_hsa052041.82818095
26PPAR signaling pathway_Homo sapiens_hsa033201.77791410
27Steroid biosynthesis_Homo sapiens_hsa001001.69626798
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69094714
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.61028948
30Bile secretion_Homo sapiens_hsa049761.50499393
31beta-Alanine metabolism_Homo sapiens_hsa004101.47990133
32Fat digestion and absorption_Homo sapiens_hsa049751.47369270
33Retinol metabolism_Homo sapiens_hsa008301.45816876
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45810912
35Caffeine metabolism_Homo sapiens_hsa002321.44844128
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41281444
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40535265
38Asthma_Homo sapiens_hsa053101.40121979
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38865648
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.34468127
41Phenylalanine metabolism_Homo sapiens_hsa003601.34394476
42Starch and sucrose metabolism_Homo sapiens_hsa005001.31887606
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29138077
44Allograft rejection_Homo sapiens_hsa053301.28943256
45Carbon metabolism_Homo sapiens_hsa012001.27109487
46Tyrosine metabolism_Homo sapiens_hsa003501.26857980
47Graft-versus-host disease_Homo sapiens_hsa053321.26748872
48Autoimmune thyroid disease_Homo sapiens_hsa053201.26291062
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26121001
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.25659775
51Folate biosynthesis_Homo sapiens_hsa007901.20728885
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.15983519
53Biosynthesis of amino acids_Homo sapiens_hsa012301.15733628
54Vitamin digestion and absorption_Homo sapiens_hsa049771.14495927
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11190843
56Arginine and proline metabolism_Homo sapiens_hsa003301.08706427
57Oxidative phosphorylation_Homo sapiens_hsa001901.02323322
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99986384
59Staphylococcus aureus infection_Homo sapiens_hsa051500.98594195
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98040595
61Glutathione metabolism_Homo sapiens_hsa004800.96400165
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.95328477
63Selenocompound metabolism_Homo sapiens_hsa004500.91765539
64Type I diabetes mellitus_Homo sapiens_hsa049400.90358938
65Primary immunodeficiency_Homo sapiens_hsa053400.87169682
66Vitamin B6 metabolism_Homo sapiens_hsa007500.84987135
67Proteasome_Homo sapiens_hsa030500.82663452
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81600538
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81195920
70Glycerolipid metabolism_Homo sapiens_hsa005610.80862146
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78455879
72ABC transporters_Homo sapiens_hsa020100.77218972
73Phototransduction_Homo sapiens_hsa047440.76595372
74Ribosome_Homo sapiens_hsa030100.76590323
75One carbon pool by folate_Homo sapiens_hsa006700.76267164
76Sulfur relay system_Homo sapiens_hsa041220.75145443
77Parkinsons disease_Homo sapiens_hsa050120.73283087
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71455014
79RNA polymerase_Homo sapiens_hsa030200.70974393
80Fatty acid biosynthesis_Homo sapiens_hsa000610.70457215
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67936899
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61026220
83Metabolic pathways_Homo sapiens_hsa011000.58692573
84Rheumatoid arthritis_Homo sapiens_hsa053230.58592495
85Pentose phosphate pathway_Homo sapiens_hsa000300.56978855
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56905510
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.55664134
88Alzheimers disease_Homo sapiens_hsa050100.52953126
89Other glycan degradation_Homo sapiens_hsa005110.51907826
90Protein export_Homo sapiens_hsa030600.51625198
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46613227
92Fructose and mannose metabolism_Homo sapiens_hsa000510.46203932
93Galactose metabolism_Homo sapiens_hsa000520.45361321
94Collecting duct acid secretion_Homo sapiens_hsa049660.44902991
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43383199
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41987935
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40084304
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37966955
99Mineral absorption_Homo sapiens_hsa049780.35815371
100Linoleic acid metabolism_Homo sapiens_hsa005910.34716391
101Antigen processing and presentation_Homo sapiens_hsa046120.34606103
102Huntingtons disease_Homo sapiens_hsa050160.28258267
103Pertussis_Homo sapiens_hsa051330.28100233
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.25911774
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24647692
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23795390
107Ether lipid metabolism_Homo sapiens_hsa005650.23380526
108Prion diseases_Homo sapiens_hsa050200.21950001
109Renin-angiotensin system_Homo sapiens_hsa046140.19691167
110Synaptic vesicle cycle_Homo sapiens_hsa047210.15819471
111Vibrio cholerae infection_Homo sapiens_hsa051100.11812775
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.08629309
113Lysine degradation_Homo sapiens_hsa003100.06983057
114Glucagon signaling pathway_Homo sapiens_hsa049220.05739011
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05511500
116Protein digestion and absorption_Homo sapiens_hsa049740.04196498
117Lysosome_Homo sapiens_hsa041420.03841687
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03836606
119Arachidonic acid metabolism_Homo sapiens_hsa005900.02150342
120Insulin resistance_Homo sapiens_hsa049310.00963803
121Phagosome_Homo sapiens_hsa041450.00577677
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0204650
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0078932
124Cardiac muscle contraction_Homo sapiens_hsa04260-0.0054415
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0045951
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0014643

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