ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	9.92047324
2	protoporphyrinogen IX metabolic process (GO:0046501)	9.81836433
3	protoporphyrinogen IX biosynthetic process (GO:0006782)	9.01731226
4	regulation of guanylate cyclase activity (GO:0031282)	7.89378619
5	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	7.72436174
6	porphyrin-containing compound biosynthetic process (GO:0006779)	7.42215108
7	heme biosynthetic process (GO:0006783)	7.20398990
8	tetrapyrrole biosynthetic process (GO:0033014)	6.69544737
9	fat-soluble vitamin biosynthetic process (GO:0042362)	6.16782344
10	porphyrin-containing compound metabolic process (GO:0006778)	6.11155026
11	fructose metabolic process (GO:0006000)	5.97149407
12	epoxygenase P450 pathway (GO:0019373)	5.91238473
13	heme metabolic process (GO:0042168)	5.88575383
14	positive regulation of guanylate cyclase activity (GO:0031284)	5.75971788
15	lipoprotein transport (GO:0042953)	5.67372750
16	regulation of bile acid biosynthetic process (GO:0070857)	5.46201829
17	diacylglycerol metabolic process (GO:0046339)	5.29765698
18	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	5.05381492
19	endocrine process (GO:0050886)	5.05381492
20	regulation of systemic arterial blood pressure by hormone (GO:0001990)	5.05381492
21	regulation of cGMP biosynthetic process (GO:0030826)	4.91996829
22	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.76418729
23	regulation of systemic arterial blood pressure (GO:0003073)	4.70308156
24	erythrocyte maturation (GO:0043249)	4.64155951
25	hormone catabolic process (GO:0042447)	4.62789849
26	drug metabolic process (GO:0017144)	4.59710953
27	lysine metabolic process (GO:0006553)	4.55612049
28	lysine catabolic process (GO:0006554)	4.55612049
29	proline biosynthetic process (GO:0006561)	4.32287865
30	regulation of cellular extravasation (GO:0002691)	4.31191647
31	nitrogen cycle metabolic process (GO:0071941)	4.30444129
32	vitamin transmembrane transport (GO:0035461)	4.28441774
33	nucleoside diphosphate biosynthetic process (GO:0009133)	4.26020793
34	renal system process involved in regulation of blood volume (GO:0001977)	4.25345014
35	very-low-density lipoprotein particle assembly (GO:0034379)	4.23741459
36	tetrapyrrole metabolic process (GO:0033013)	4.23668352
37	hemoglobin metabolic process (GO:0020027)	4.16440420
38	glutamine family amino acid biosynthetic process (GO:0009084)	4.13165556
39	plasma lipoprotein particle assembly (GO:0034377)	4.12223322
40	glucuronate metabolic process (GO:0019585)	4.06881696
41	uronic acid metabolic process (GO:0006063)	4.06881696
42	cellular glucuronidation (GO:0052695)	4.04400696
43	positive regulation of pseudopodium assembly (GO:0031274)	4.02612015
44	GDP-mannose metabolic process (GO:0019673)	3.98517985
45	regulation of cGMP metabolic process (GO:0030823)	3.97684667
46	antibacterial humoral response (GO:0019731)	3.97641843
47	adhesion of symbiont to host cell (GO:0044650)	3.95933191
48	virion attachment to host cell (GO:0019062)	3.95933191
49	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.94963760
50	peptide hormone processing (GO:0016486)	3.91788779
51	proline metabolic process (GO:0006560)	3.86014990
52	antimicrobial humoral response (GO:0019730)	3.85437973
53	peptide catabolic process (GO:0043171)	3.82158361
54	vitamin A metabolic process (GO:0006776)	3.81927922
55	glycosphingolipid catabolic process (GO:0046479)	3.80155869
56	regulation of vitamin metabolic process (GO:0030656)	3.78859715
57	glycolipid catabolic process (GO:0019377)	3.76921186
58	protein-lipid complex assembly (GO:0065005)	3.75544378
59	regulation of triglyceride catabolic process (GO:0010896)	3.72238342
60	tricarboxylic acid cycle (GO:0006099)	3.71214330
61	2-oxoglutarate metabolic process (GO:0006103)	3.67953887
62	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.67831694
63	cellular response to nitric oxide (GO:0071732)	3.65390165
64	erythrocyte development (GO:0048821)	3.63685556
65	digestion (GO:0007586)	3.61886677
66	cysteine metabolic process (GO:0006534)	3.61869180
67	carnitine metabolic process (GO:0009437)	3.58932836
68	adhesion of symbiont to host (GO:0044406)	3.58583397
69	regulation of pseudopodium assembly (GO:0031272)	3.58541238
70	positive regulation of respiratory burst (GO:0060267)	3.52600005
71	vitamin transport (GO:0051180)	3.52118093
72	cGMP-mediated signaling (GO:0019934)	3.51143100
73	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.49960621
74	positive regulation of cGMP biosynthetic process (GO:0030828)	3.45060333
75	arginine metabolic process (GO:0006525)	3.44755043
76	amino-acid betaine metabolic process (GO:0006577)	3.44209030
77	fatty acid beta-oxidation (GO:0006635)	3.40667319
78	maintenance of gastrointestinal epithelium (GO:0030277)	3.35348542
79	triglyceride biosynthetic process (GO:0019432)	3.35267462
80	intestinal cholesterol absorption (GO:0030299)	3.33137405
81	response to methylmercury (GO:0051597)	3.32023818
82	glyoxylate metabolic process (GO:0046487)	3.31404827
83	heme transport (GO:0015886)	3.30288325
84	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.29809008
85	vitamin biosynthetic process (GO:0009110)	3.28766230
86	NADH metabolic process (GO:0006734)	3.27729205
87	sulfate transmembrane transport (GO:1902358)	3.27719926
88	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.27230692
89	regulation of cholesterol metabolic process (GO:0090181)	3.26506054
90	phospholipid efflux (GO:0033700)	3.26097491
91	lipoprotein metabolic process (GO:0042157)	3.25564932
92	glycerol metabolic process (GO:0006071)	3.23636221
93	pigment biosynthetic process (GO:0046148)	3.22213876
94	aspartate family amino acid catabolic process (GO:0009068)	3.22195260
95	intestinal absorption (GO:0050892)	3.22063211
96	glutathione biosynthetic process (GO:0006750)	3.21860062
97	quinone biosynthetic process (GO:1901663)	3.21640274
98	response to nitric oxide (GO:0071731)	3.21279608
99	transcytosis (GO:0045056)	3.20617285
100	acylglycerol biosynthetic process (GO:0046463)	3.18744953
101	neutral lipid biosynthetic process (GO:0046460)	3.18744953
102	flavonoid metabolic process (GO:0009812)	3.18699509
103	fat-soluble vitamin metabolic process (GO:0006775)	3.17843080
104	carnitine shuttle (GO:0006853)	3.17297395
105	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.17149615
106	sulfur amino acid catabolic process (GO:0000098)	3.16659310
107	digestive system process (GO:0022600)	3.16099837
108	ethanol oxidation (GO:0006069)	3.12793301
109	nonribosomal peptide biosynthetic process (GO:0019184)	3.12753402
110	fatty acid oxidation (GO:0019395)	3.12614657
111	positive regulation of lipid catabolic process (GO:0050996)	3.12120118
112	positive regulation of triglyceride lipase activity (GO:0061365)	3.11133152
113	positive regulation of lipoprotein lipase activity (GO:0051006)	3.11133152
114	alkaloid metabolic process (GO:0009820)	3.10142802
115	sarcomere organization (GO:0045214)	3.09865121
116	drug catabolic process (GO:0042737)	3.07931821
117	positive regulation of glycoprotein metabolic process (GO:1903020)	3.07637909
118	midgut development (GO:0007494)	3.07617677
119	drinking behavior (GO:0042756)	3.07325762
120	bile acid metabolic process (GO:0008206)	3.07297946
121	response to lead ion (GO:0010288)	3.06654541
122	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.06401471
123	kynurenine metabolic process (GO:0070189)	3.06240598
124	sphingolipid catabolic process (GO:0030149)	3.06043743
125	ceramide catabolic process (GO:0046514)	3.05407381
126	lipid oxidation (GO:0034440)	3.04437275
127	fatty acid transmembrane transport (GO:1902001)	3.04384589
128	homocysteine metabolic process (GO:0050667)	3.03565615
129	fatty acid catabolic process (GO:0009062)	3.00674384
130	regulation of cholesterol esterification (GO:0010872)	2.99147369
131	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.96610367
132	L-phenylalanine metabolic process (GO:0006558)	2.96610367
133	plasma lipoprotein particle organization (GO:0071827)	2.96047241
134	tricarboxylic acid metabolic process (GO:0072350)	2.95527249
135	pigment metabolic process (GO:0042440)	2.94161562
136	high-density lipoprotein particle remodeling (GO:0034375)	2.93643672
137	positive regulation of triglyceride metabolic process (GO:0090208)	2.91964312
138	carnitine transmembrane transport (GO:1902603)	2.91111095
139	alpha-linolenic acid metabolic process (GO:0036109)	2.91003363
140	cofactor biosynthetic process (GO:0051188)	2.90253481
141	carnitine transport (GO:0015879)	2.88334799
142	amino-acid betaine transport (GO:0015838)	2.88334799
143	valine metabolic process (GO:0006573)	2.86952897
144	oxidative phosphorylation (GO:0006119)	2.84624512
145	protein-lipid complex subunit organization (GO:0071825)	2.82245021
146	oxaloacetate metabolic process (GO:0006107)	2.81745483
147	response to arsenic-containing substance (GO:0046685)	2.81129476
148	erythrocyte differentiation (GO:0030218)	2.77467124
149	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.75580366
150	L-phenylalanine catabolic process (GO:0006559)	2.75580366
151	protein-lipid complex remodeling (GO:0034368)	2.74291006
152	macromolecular complex remodeling (GO:0034367)	2.74291006
153	plasma lipoprotein particle remodeling (GO:0034369)	2.74291006
154	negative regulation of sterol transport (GO:0032372)	2.73048012
155	negative regulation of cholesterol transport (GO:0032375)	2.73048012
156	short-chain fatty acid metabolic process (GO:0046459)	2.68841385
157	negative regulation of viral entry into host cell (GO:0046597)	2.68320124
158	reverse cholesterol transport (GO:0043691)	2.67373573
159	ethanol metabolic process (GO:0006067)	2.67073330
160	phospholipid homeostasis (GO:0055091)	2.67043856
161	aromatic amino acid family catabolic process (GO:0009074)	2.66776377
162	drug transmembrane transport (GO:0006855)	2.66697485
163	regulation of cholesterol homeostasis (GO:2000188)	2.66688769
164	urea cycle (GO:0000050)	2.66502373
165	urea metabolic process (GO:0019627)	2.66502373
166	cellular ketone body metabolic process (GO:0046950)	2.66473475
167	cholesterol homeostasis (GO:0042632)	2.66318777
168	cholesterol efflux (GO:0033344)	2.65236468
169	tryptophan catabolic process (GO:0006569)	2.64907202
170	indole-containing compound catabolic process (GO:0042436)	2.64907202
171	indolalkylamine catabolic process (GO:0046218)	2.64907202
172	monocarboxylic acid catabolic process (GO:0072329)	2.63817019
173	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.63458163
174	acetyl-CoA metabolic process (GO:0006084)	2.62369734
175	plasma lipoprotein particle clearance (GO:0034381)	2.61333023
176	bile acid and bile salt transport (GO:0015721)	2.60450857
177	myeloid cell development (GO:0061515)	2.60401456
178	sterol homeostasis (GO:0055092)	2.59675756
179	purine nucleotide salvage (GO:0032261)	2.57787779
180	response to nitrosative stress (GO:0051409)	2.55933183

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.28567916
2	CDX2_20551321_ChIP-Seq_CACO-2_Human	4.12061926
3	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.06892076
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.01520702
5	GATA1_22025678_ChIP-Seq_K562_Human	3.77256241
6	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.44335444
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.41171426
8	E2F7_22180533_ChIP-Seq_HELA_Human	3.12270380
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.87085165
10	GATA1_19941826_ChIP-Seq_K562_Human	2.57153358
11	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	2.54187999
12	SCL_19346495_ChIP-Seq_HPC-7_Human	2.50310808
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.48481034
14	GATA1_19941827_ChIP-Seq_MEL_Mouse	2.45161384
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.36416472
16	GATA1_22383799_ChIP-Seq_G1ME_Mouse	2.12245106
17	* TET1_21451524_ChIP-Seq_MESCs_Mouse	2.07327893
18	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.03269162
19	ZNF263_19887448_ChIP-Seq_K562_Human	1.99204166
20	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96978430
21	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.96590085
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.91545100
23	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.90864286
24	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.80367880
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.80155938
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77988629
27	VDR_21846776_ChIP-Seq_THP-1_Human	1.76138747
28	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74755461
29	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.73502044
30	SA1_27219007_Chip-Seq_Bcells_Human	1.72760499
31	GATA2_19941826_ChIP-Seq_K562_Human	1.71578539
32	MYC_22102868_ChIP-Seq_BL_Human	1.69813862
33	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.67370719
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.67031592
35	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.66637254
36	* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.64383949
37	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.63473245
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62898181
39	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.61247957
40	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.58575763
41	CTCF_27219007_Chip-Seq_Bcells_Human	1.57677305
42	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.54987686
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.49077349
44	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48353089
45	PHF8_20622854_ChIP-Seq_HELA_Human	1.47063681
46	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.46622508
47	SOX2_20726797_ChIP-Seq_SW620_Human	1.44755286
48	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.43667937
49	CREB1_26743006_Chip-Seq_LNCaP_Human	1.41392433
50	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.40976518
51	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.40242515
52	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.40220661
53	E2F1_20622854_ChIP-Seq_HELA_Human	1.39575117
54	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.39554555
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.38538240
56	MAF_26560356_Chip-Seq_TH1_Human	1.35428962
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.35262962
58	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.35138991
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.34440701
60	* MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.34227469
61	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.33014743
62	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.32725018
63	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.31642365
64	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.30937365
65	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.30781778
66	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.30269115
67	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29857858
68	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.29707335
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29350488
70	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.27574458
71	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.24826932
72	* ETS1_21867929_ChIP-Seq_TH2_Mouse	1.24404533
73	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.23182697
74	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.21813583
75	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.19986676
76	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.19295683
77	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.18885425
78	* RUNX1_22412390_ChIP-Seq_EML_Mouse	1.18112104
79	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.16139555
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16074616
81	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.15989549
82	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.15362625
83	TCF7_22412390_ChIP-Seq_EML_Mouse	1.15170789
84	CTCF_20526341_ChIP-Seq_ESCs_Human	1.14926386
85	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.14721514
86	UTX_26944678_Chip-Seq_JUKART_Human	1.14033064
87	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13710499
88	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.13238215
89	NCOR1_26117541_ChIP-Seq_K562_Human	1.12495772
90	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.12246741
91	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11896575
92	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.10622397
93	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.10034815
94	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.09987131
95	SMC4_20622854_ChIP-Seq_HELA_Human	1.09683797
96	LXR_22292898_ChIP-Seq_THP-1_Human	1.09617015
97	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08045961
98	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.07326107
99	VDR_24763502_ChIP-Seq_THP-1_Human	1.07185191
100	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.07082176
101	BCL6_27268052_Chip-Seq_Bcells_Human	1.07035070
102	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.06685665
103	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05685808
104	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05545305
105	ATF3_27146783_Chip-Seq_COLON_Human	1.05116842
106	* GATA6_25053715_ChIP-Seq_YYC3_Human	1.05014231
107	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.04514934
108	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04288030
109	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02917510
110	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.02636813
111	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.02604926
112	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.02384945
113	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.02320073
114	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02012681
115	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.01792044
116	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.01316445
117	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01078190
118	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.01064429
119	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.00772354
120	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.00535520
121	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.00167766
122	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00077357
123	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99767469
124	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99682527
125	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.98198097
126	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.96937072
127	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.96766173
128	TP63_22573176_ChIP-Seq_HFKS_Human	0.96762236
129	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96656234
130	P300_27268052_Chip-Seq_Bcells_Human	0.96538353
131	CLOCK_20551151_ChIP-Seq_293T_Human	0.96037829
132	AR_21909140_ChIP-Seq_LNCAP_Human	0.95713972
133	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95615235
134	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.95263096
135	BCOR_27268052_Chip-Seq_Bcells_Human	0.94874625
136	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.93461580
137	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92964247
138	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92459993
139	GATA4_25053715_ChIP-Seq_YYC3_Human	0.91883212
140	RACK7_27058665_Chip-Seq_MCF-7_Human	0.91735624
141	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91586500
142	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.90094472
143	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89224389
144	P68_20966046_ChIP-Seq_HELA_Human	0.87929413
145	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.87143413
146	MAF_26560356_Chip-Seq_TH2_Human	0.87094941
147	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.86923711
148	MYB_26560356_Chip-Seq_TH1_Human	0.86630295
149	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85852853
150	* ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.85471797
151	CTCF_21964334_Chip-Seq_Bcells_Human	0.85465444
152	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.84313988
153	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.84136327
154	* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.83150363
155	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.83000922

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003656_abnormal_erythrocyte_physiolo	5.79872752
2	MP0004147_increased_porphyrin_level	5.44537286
3	MP0005360_urolithiasis	4.74967917
4	MP0002139_abnormal_hepatobiliary_system	4.13598478
5	MP0009379_abnormal_foot_pigmentation	4.03014033
6	MP0010234_abnormal_vibrissa_follicle	3.61253663
7	MP0003183_abnormal_peptide_metabolism	3.25230560
8	MP0005085_abnormal_gallbladder_physiolo	3.24943168
9	MP0003806_abnormal_nucleotide_metabolis	2.96211437
10	MP0005365_abnormal_bile_salt	2.72161532
11	MP0009840_abnormal_foam_cell	2.65281194
12	MP0005083_abnormal_biliary_tract	2.44712517
13	MP0008875_abnormal_xenobiotic_pharmacok	2.41767409
14	MP0005409_darkened_coat_color	2.40112652
15	MP0001666_abnormal_nutrient_absorption	2.40008167
16	MP0002837_dystrophic_cardiac_calcinosis	2.28678858
17	MP0003646_muscle_fatigue	2.26452492
18	MP0001664_abnormal_digestion	2.13904752
19	MP0000678_abnormal_parathyroid_gland	2.10208156
20	MP0003252_abnormal_bile_duct	2.06843845
21	MP0001188_hyperpigmentation	2.02947293
22	MP0010329_abnormal_lipoprotein_level	1.97963970
23	MP0006036_abnormal_mitochondrial_physio	1.91245967
24	MP0003191_abnormal_cellular_cholesterol	1.84156469
25	MP0004084_abnormal_cardiac_muscle	1.83001293
26	MP0004215_abnormal_myocardial_fiber	1.78066845
27	MP0004043_abnormal_pH_regulation	1.68864458
28	MP0005330_cardiomyopathy	1.61467880
29	MP0000609_abnormal_liver_physiology	1.58437407
30	MP0008775_abnormal_heart_ventricle	1.55454016
31	MP0005319_abnormal_enzyme/_coenzyme	1.54018050
32	MP0000749_muscle_degeneration	1.53807528
33	MP0001765_abnormal_ion_homeostasis	1.52485223
34	MP0005636_abnormal_mineral_homeostasis	1.52308863
35	MP0003718_maternal_effect	1.47657083
36	MP0005397_hematopoietic_system_phenotyp	1.44884522
37	MP0001545_abnormal_hematopoietic_system	1.44884522
38	MP0003186_abnormal_redox_activity	1.44297677
39	MP0005332_abnormal_amino_acid	1.42113016
40	MP0003879_abnormal_hair_cell	1.39373798
41	MP0004858_abnormal_nervous_system	1.37651430
42	MP0002822_catalepsy	1.33644745
43	MP0009643_abnormal_urine_homeostasis	1.33356292
44	MP0002876_abnormal_thyroid_physiology	1.31196413
45	MP0004130_abnormal_muscle_cell	1.31155052
46	MP0000538_abnormal_urinary_bladder	1.30241584
47	MP0000490_abnormal_crypts_of	1.29542689
48	MP0005464_abnormal_platelet_physiology	1.28373024
49	MP0000751_myopathy	1.26475253
50	MP0000685_abnormal_immune_system	1.24437879
51	MP0002796_impaired_skin_barrier	1.24228479
52	MP0002396_abnormal_hematopoietic_system	1.23317233
53	MP0004036_abnormal_muscle_relaxation	1.21866280
54	MP0003705_abnormal_hypodermis_morpholog	1.21177886
55	MP0005166_decreased_susceptibility_to	1.20440691
56	MP0002118_abnormal_lipid_homeostasis	1.19113152
57	MP0003221_abnormal_cardiomyocyte_apopto	1.17995141
58	MP0000462_abnormal_digestive_system	1.16951953
59	MP0004782_abnormal_surfactant_physiolog	1.15417986
60	MP0001544_abnormal_cardiovascular_syste	1.14943782
61	MP0005385_cardiovascular_system_phenoty	1.14943782
62	MP0005584_abnormal_enzyme/coenzyme_acti	1.11648743
63	MP0010630_abnormal_cardiac_muscle	1.10554259
64	MP0002136_abnormal_kidney_physiology	1.09687488
65	MP0001764_abnormal_homeostasis	1.09226964
66	MP0006054_spinal_hemorrhage	1.09131146
67	MP0002138_abnormal_hepatobiliary_system	1.09013563
68	MP0004264_abnormal_extraembryonic_tissu	1.08190057
69	MP0002972_abnormal_cardiac_muscle	1.07612584
70	MP0000537_abnormal_urethra_morphology	1.07434906
71	MP0005501_abnormal_skin_physiology	1.05170963
72	MP0005535_abnormal_body_temperature	1.04962611
73	MP0010155_abnormal_intestine_physiology	1.04922317
74	MP0004087_abnormal_muscle_fiber	1.04524248
75	MP0001756_abnormal_urination	1.02363698
76	MP0000598_abnormal_liver_morphology	1.01982219
77	MP0005266_abnormal_metabolism	1.01834912
78	MP0003866_abnormal_defecation	1.01733415
79	MP0005666_abnormal_adipose_tissue	1.01522771
80	MP0003300_gastrointestinal_ulcer	0.98371580
81	MP0009764_decreased_sensitivity_to	0.96977119
82	MP0008469_abnormal_protein_level	0.96502434
83	MP0005448_abnormal_energy_balance	0.96358723
84	MP0002269_muscular_atrophy	0.96168506
85	MP0000566_synostosis	0.95282607
86	MP0005381_digestive/alimentary_phenotyp	0.94637525
87	MP0009785_altered_susceptibility_to	0.94554342
88	MP0004270_analgesia	0.94255516
89	MP0001873_stomach_inflammation	0.92918304
90	MP0003693_abnormal_embryo_hatching	0.91171651
91	MP0005025_abnormal_response_to	0.90938968
92	MP0009763_increased_sensitivity_to	0.90654087
93	MP0002098_abnormal_vibrissa_morphology	0.90481840
94	MP0004957_abnormal_blastocyst_morpholog	0.90194896
95	MP0010352_gastrointestinal_tract_polyps	0.89730449
96	MP0009115_abnormal_fat_cell	0.89622109
97	MP0002398_abnormal_bone_marrow	0.88911048
98	MP0000689_abnormal_spleen_morphology	0.88599019
99	MP0000343_altered_response_to	0.88004826
100	MP0002722_abnormal_immune_system	0.87057221
101	MP0001853_heart_inflammation	0.86614674
102	MP0003868_abnormal_feces_composition	0.85273372
103	MP0003828_pulmonary_edema	0.84815642
104	MP0004019_abnormal_vitamin_homeostasis	0.84619885
105	MP0003111_abnormal_nucleus_morphology	0.81882772
106	MP0006035_abnormal_mitochondrial_morpho	0.81816527
107	MP0006138_congestive_heart_failure	0.80432871
108	MP0002166_altered_tumor_susceptibility	0.80371249
109	MP0001663_abnormal_digestive_system	0.79612369
110	MP0002429_abnormal_blood_cell	0.79285545
111	MP0005058_abnormal_lysosome_morphology	0.76777118
112	MP0005174_abnormal_tail_pigmentation	0.76706355
113	MP0005451_abnormal_body_composition	0.75823693
114	MP0005375_adipose_tissue_phenotype	0.75266992
115	MP0005620_abnormal_muscle_contractility	0.74996890
116	MP0001835_abnormal_antigen_presentation	0.73006218
117	MP0000230_abnormal_systemic_arterial	0.72383984
118	MP0005670_abnormal_white_adipose	0.72194009
119	MP0000015_abnormal_ear_pigmentation	0.72103751
120	MP0009333_abnormal_splenocyte_physiolog	0.71956146
121	MP0009642_abnormal_blood_homeostasis	0.71196636
122	MP0000747_muscle_weakness	0.70218054
123	MP0004484_altered_response_of	0.69445277
124	MP0003436_decreased_susceptibility_to	0.69433342
125	MP0004947_skin_inflammation	0.68482526
126	MP0005376_homeostasis/metabolism_phenot	0.68314575
127	MP0001881_abnormal_mammary_gland	0.68057586
128	MP0010307_abnormal_tumor_latency	0.67557996
129	MP0004185_abnormal_adipocyte_glucose	0.66550108
130	MP0003195_calcinosis	0.66422146
131	MP0002132_abnormal_respiratory_system	0.66421211
132	MP0002971_abnormal_brown_adipose	0.66394941
133	MP0001845_abnormal_inflammatory_respons	0.66239921
134	MP0004808_abnormal_hematopoietic_stem	0.66210507
135	MP0000477_abnormal_intestine_morphology	0.66200201
136	MP0002106_abnormal_muscle_physiology	0.65573083
137	MP0005334_abnormal_fat_pad	0.65500083
138	MP0003953_abnormal_hormone_level	0.64782567
139	MP0003137_abnormal_impulse_conducting	0.63480217
140	MP0002078_abnormal_glucose_homeostasis	0.62479849
141	MP0008872_abnormal_physiological_respon	0.61658537
142	MP0002249_abnormal_larynx_morphology	0.57287104
143	MP0003315_abnormal_perineum_morphology	0.57237156
144	MP0001501_abnormal_sleep_pattern	0.56349090
145	MP0003329_amyloid_beta_deposits	0.53583673
146	MP0002970_abnormal_white_adipose	0.48983546
147	MP0000681_abnormal_thyroid_gland	0.48469253
148	MP0001849_ear_inflammation	0.48133418
149	MP0001485_abnormal_pinna_reflex	0.46194851
150	MP0005645_abnormal_hypothalamus_physiol	0.44275187
151	MP0000003_abnormal_adipose_tissue	0.43161225
152	MP0000604_amyloidosis	0.42787322
153	MP0002089_abnormal_postnatal_growth/wei	0.42346162
154	MP0002069_abnormal_eating/drinking_beha	0.39858483
155	MP0009931_abnormal_skin_appearance	0.38563003

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Poikilocytosis (HP:0004447)	7.60472221
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	6.96944262
3	Abnormality of proline metabolism (HP:0010907)	6.38178603
4	Hydroxyprolinuria (HP:0003080)	6.38178603
5	Acanthocytosis (HP:0001927)	6.05706452
6	Reticulocytosis (HP:0001923)	5.19735681
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.95361432
8	Cholelithiasis (HP:0001081)	4.71198276
9	Abnormality of vitamin B metabolism (HP:0004340)	4.56781891
10	Hyperbilirubinemia (HP:0002904)	4.48619440
11	Confusion (HP:0001289)	4.35503009
12	Hypochromic microcytic anemia (HP:0004840)	4.29725465
13	Abnormal gallbladder morphology (HP:0012437)	4.26963470
14	Widely patent fontanelles and sutures (HP:0004492)	4.20339466
15	Chronic diarrhea (HP:0002028)	4.09857833
16	Ileus (HP:0002595)	3.79601586
17	Abnormality of vitamin metabolism (HP:0100508)	3.73199902
18	Hyperactive renin-angiotensin system (HP:0000841)	3.69535399
19	Decreased circulating renin level (HP:0003351)	3.61905576
20	Diaphragmatic weakness (HP:0009113)	3.57231351
21	Metabolic alkalosis (HP:0200114)	3.56608685
22	Systemic lupus erythematosus (HP:0002725)	3.54675507
23	Glycosuria (HP:0003076)	3.53320561
24	Abnormality of urine glucose concentration (HP:0011016)	3.53320561
25	Polycythemia (HP:0001901)	3.49208529
26	Abnormality of reticulocytes (HP:0004312)	3.45807051
27	Hemorrhage of the eye (HP:0011885)	3.32841162
28	Hypoglycemic coma (HP:0001325)	3.31870291
29	Megaloblastic anemia (HP:0001889)	3.30276817
30	Wide cranial sutures (HP:0010537)	3.27634819
31	Alkalosis (HP:0001948)	3.26095914
32	Myoglobinuria (HP:0002913)	3.25928322
33	Nausea (HP:0002018)	3.25883617
34	Hyperammonemia (HP:0001987)	3.23055665
35	Thin bony cortex (HP:0002753)	3.21050963
36	Abdominal distention (HP:0003270)	3.19433873
37	Intrahepatic cholestasis (HP:0001406)	3.18531045
38	Ventricular tachycardia (HP:0004756)	3.12421906
39	Abnormality of fatty-acid metabolism (HP:0004359)	3.10724521
40	Hypobetalipoproteinemia (HP:0003563)	3.08428009
41	Abnormal gallbladder physiology (HP:0012438)	3.06061338
42	Cholecystitis (HP:0001082)	3.06061338
43	Abnormality of renin-angiotensin system (HP:0000847)	3.05817705
44	Abnormality of the gallbladder (HP:0005264)	3.05429729
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.98921584
46	Dicarboxylic aciduria (HP:0003215)	2.98921584
47	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.98132135
48	Xanthomatosis (HP:0000991)	2.94796020
49	Pigmentary retinal degeneration (HP:0001146)	2.93779301
50	Paralysis (HP:0003470)	2.92372047
51	Nephrolithiasis (HP:0000787)	2.90967842
52	Increased purine levels (HP:0004368)	2.89564249
53	Hyperuricemia (HP:0002149)	2.89564249
54	Right ventricular cardiomyopathy (HP:0011663)	2.86613424
55	Rhabdomyolysis (HP:0003201)	2.84711084
56	Microcytic anemia (HP:0001935)	2.84356550
57	Sudden death (HP:0001699)	2.82680139
58	Abnormality of small intestinal villus morphology (HP:0011472)	2.82332042
59	Villous atrophy (HP:0011473)	2.82332042
60	Increased serum ferritin (HP:0003281)	2.77411108
61	Metabolic acidosis (HP:0001942)	2.73071203
62	Abnormal urine phosphate concentration (HP:0012599)	2.71982665
63	Palpitations (HP:0001962)	2.70402942
64	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.69900476
65	Ketosis (HP:0001946)	2.69862747
66	Delayed epiphyseal ossification (HP:0002663)	2.69421540
67	Hypophosphatemia (HP:0002148)	2.68186889
68	Hyperparathyroidism (HP:0000843)	2.66121912
69	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.64852770
70	Deep venous thrombosis (HP:0002625)	2.63701356
71	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.63193846
72	Hypochromic anemia (HP:0001931)	2.62662034
73	Abnormality of iron homeostasis (HP:0011031)	2.62444787
74	Exercise-induced muscle cramps (HP:0003710)	2.59190206
75	Steatorrhea (HP:0002570)	2.58000402
76	Lipoatrophy (HP:0100578)	2.55887967
77	Hyperphosphaturia (HP:0003109)	2.54945533
78	Hypolipoproteinemia (HP:0010981)	2.54758483
79	Petechiae (HP:0000967)	2.53931825
80	Posterior subcapsular cataract (HP:0007787)	2.53388925
81	Hepatocellular carcinoma (HP:0001402)	2.53227832
82	Hyperglycinuria (HP:0003108)	2.50914666
83	Abnormality of transition element cation homeostasis (HP:0011030)	2.48332953
84	Increased muscle lipid content (HP:0009058)	2.47434452
85	Ketoacidosis (HP:0001993)	2.46511300
86	Hypotension (HP:0002615)	2.41381579
87	Congenital sensorineural hearing impairment (HP:0008527)	2.39180311
88	Flat acetabular roof (HP:0003180)	2.38964826
89	Generalized aminoaciduria (HP:0002909)	2.37828357
90	Abnormality of pyrimidine metabolism (HP:0004353)	2.34348348
91	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.34028746
92	Gout (HP:0001997)	2.33510164
93	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.33029758
94	Pustule (HP:0200039)	2.32983469
95	Potter facies (HP:0002009)	2.32944763
96	Facial shape deformation (HP:0011334)	2.32944763
97	Hepatic necrosis (HP:0002605)	2.32141389
98	Abnormal platelet function (HP:0011869)	2.26414451
99	Impaired platelet aggregation (HP:0003540)	2.26414451
100	Exercise-induced myalgia (HP:0003738)	2.25351564
101	Pili torti (HP:0003777)	2.24816831
102	Subcapsular cataract (HP:0000523)	2.23834068
103	Dilated cardiomyopathy (HP:0001644)	2.22638946
104	Hypoalphalipoproteinemia (HP:0003233)	2.22398404
105	Autoimmune thrombocytopenia (HP:0001973)	2.21365657
106	Abnormality of serine family amino acid metabolism (HP:0010894)	2.20930649
107	Abnormality of glycine metabolism (HP:0010895)	2.20930649
108	Gastrointestinal dysmotility (HP:0002579)	2.20279299
109	Myopathic facies (HP:0002058)	2.18679606
110	Hyperlipoproteinemia (HP:0010980)	2.15698109
111	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.14381259
112	Multiple enchondromatosis (HP:0005701)	2.13419699
113	Cutaneous photosensitivity (HP:0000992)	2.13339200
114	Vomiting (HP:0002013)	2.11168762
115	Abnormality of the costochondral junction (HP:0000919)	2.10766842
116	Subaortic stenosis (HP:0001682)	2.10234807
117	Abnormality of the left ventricular outflow tract (HP:0011103)	2.10234807
118	Prolonged partial thromboplastin time (HP:0003645)	2.08824743
119	Abnormal number of erythroid precursors (HP:0012131)	2.06351880
120	Macrocytic anemia (HP:0001972)	2.06079139
121	Increased intramyocellular lipid droplets (HP:0012240)	2.05759929
122	Hyperphosphatemia (HP:0002905)	2.05599390
123	Cerebral palsy (HP:0100021)	2.02821340
124	Focal segmental glomerulosclerosis (HP:0000097)	2.01188674
125	Cerebral edema (HP:0002181)	1.98625770
126	Abnormality of magnesium homeostasis (HP:0004921)	1.98396258
127	Asymmetric septal hypertrophy (HP:0001670)	1.98109571
128	Enlarged epiphyses (HP:0010580)	1.97833603
129	Hypercholesterolemia (HP:0003124)	1.97637958
130	Symptomatic seizures (HP:0011145)	1.95202098
131	Neonatal onset (HP:0003623)	1.94916914
132	Urticaria (HP:0001025)	1.94431214
133	Abnormal hair laboratory examination (HP:0003328)	1.94415124
134	Abnormal enzyme/coenzyme activity (HP:0012379)	1.93372851
135	Late onset (HP:0003584)	1.92890683
136	Renal tubular acidosis (HP:0001947)	1.92855127
137	Syncope (HP:0001279)	1.92141707
138	Ragged-red muscle fibers (HP:0003200)	1.91261582
139	Abnormality of alkaline phosphatase activity (HP:0004379)	1.90307733
140	Prolonged bleeding time (HP:0003010)	1.89361869
141	Insomnia (HP:0100785)	1.87992777
142	Abnormality of cells of the erythroid lineage (HP:0012130)	1.87733835
143	Epidermoid cyst (HP:0200040)	1.87688885
144	Lethargy (HP:0001254)	1.87506499
145	Hypertriglyceridemia (HP:0002155)	1.87266700
146	Renal tubular dysfunction (HP:0000124)	1.85847662
147	Atrial fibrillation (HP:0005110)	1.85238582
148	Abnormality of purine metabolism (HP:0004352)	1.84529836
149	Protuberant abdomen (HP:0001538)	1.83756930
150	Proximal tubulopathy (HP:0000114)	1.83588174
151	Malnutrition (HP:0004395)	1.83178897
152	Fat malabsorption (HP:0002630)	1.83042555
153	Atrioventricular block (HP:0001678)	1.82666930
154	Irritability (HP:0000737)	1.82355065
155	Abnormal tarsal ossification (HP:0008369)	1.82246600
156	Bundle branch block (HP:0011710)	1.80985646
157	Esophageal neoplasm (HP:0100751)	1.80706547
158	Neoplasm of head and neck (HP:0012288)	1.80706547
159	Calf muscle hypertrophy (HP:0008981)	1.80074738
160	Epistaxis (HP:0000421)	1.79526165
161	Heart block (HP:0012722)	1.78740913
162	Abnormality of nucleobase metabolism (HP:0010932)	1.78622816
163	Multiple lipomas (HP:0001012)	1.70000217
164	Hyponatremia (HP:0002902)	1.69735700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	7.02061392
2	EPHA2	3.84989663
3	EIF2AK1	3.24364155
4	PKN2	3.10814922
5	BCKDK	3.07749214
6	TESK2	2.76283643
7	TRIB3	2.70905669
8	FLT3	2.54506039
9	TTN	2.43919355
10	ERN1	2.35539285
11	STK4	2.35086963
12	NME2	2.20293666
13	MAP4K1	2.05782606
14	EEF2K	1.95826339
15	LMTK2	1.95357708
16	MAP3K10	1.83407676
17	MYLK	1.77841583
18	TBK1	1.77618922
19	MAPK11	1.70763468
20	MAP2K3	1.67305442
21	GRK6	1.67018122
22	MET	1.65158256
23	RIPK1	1.63763643
24	MAPKAPK3	1.60596941
25	SMG1	1.60177296
26	NEK1	1.56792186
27	TYK2	1.56763460
28	EPHA4	1.53890412
29	MAP3K11	1.53677446
30	STK10	1.52738515
31	TAOK3	1.42100021
32	KIT	1.40347118
33	EPHB2	1.39103314
34	ICK	1.38858770
35	FGFR4	1.35849748
36	KDR	1.35727533
37	TLK1	1.34044095
38	PRPF4B	1.31834327
39	ZAK	1.29885661
40	MAP3K1	1.28257999
41	IKBKE	1.27820935
42	PIM2	1.25792975
43	STK39	1.25235369
44	KSR2	1.24070940
45	PIM1	1.23421536
46	PDK4	1.22605737
47	PDK3	1.22605737
48	MAP3K2	1.16671093
49	IRAK3	1.15973020
50	PDPK1	1.13200287
51	CDK12	1.11596491
52	TIE1	1.11348645
53	TGFBR2	1.09524866
54	TRPM7	1.08224027
55	STK24	1.08188189
56	PINK1	1.06588626
57	MAP3K8	1.05623406
58	DDR2	1.04302095
59	TESK1	1.03731879
60	TAOK1	1.03158125
61	RIPK4	1.00840666
62	OBSCN	1.00014619
63	PRKAA2	0.98776546
64	NEK2	0.98373763
65	MAP2K2	0.97695434
66	NME1	0.96766723
67	WNK4	0.95720053
68	PRKAA1	0.95115240
69	PTK6	0.94647796
70	CDK4	0.93305772
71	LRRK2	0.91879862
72	STK16	0.91149110
73	OXSR1	0.90182024
74	JAK3	0.88928862
75	PRKG2	0.88836631
76	JAK2	0.85597277
77	DYRK3	0.85538846
78	PIK3CA	0.84036602
79	CDC7	0.81998263
80	MAP3K12	0.79834063
81	BMX	0.79329871
82	ZAP70	0.79141612
83	MAP3K7	0.78213574
84	SYK	0.78061728
85	RPS6KB2	0.77699548
86	MST1R	0.75632098
87	RPS6KA6	0.73133949
88	RPS6KC1	0.72885196
89	RPS6KL1	0.72885196
90	AURKB	0.71923525
91	MAP3K3	0.71483436
92	CDC42BPA	0.67757555
93	SCYL2	0.65070963
94	MST4	0.64868973
95	CDK6	0.63331278
96	VRK1	0.62495358
97	SIK1	0.62392718
98	PHKG1	0.61578197
99	PHKG2	0.61578197
100	ERBB2	0.61306022
101	RPS6KA5	0.60702134
102	DYRK1B	0.59833145
103	DMPK	0.56756036
104	BTK	0.56477036
105	TTK	0.55919025
106	GRK7	0.55742244
107	NEK9	0.55721468
108	IKBKB	0.55210757
109	STK3	0.54887752
110	MATK	0.54051011
111	ABL2	0.51864011
112	EPHA3	0.51075306
113	TAOK2	0.50178856
114	MUSK	0.49686421
115	BRAF	0.49445911
116	FGFR3	0.48673449
117	WEE1	0.48465677
118	PAK4	0.48102253
119	MAP2K6	0.47123152
120	MAPK12	0.46487806
121	CAMK2D	0.46395279
122	JAK1	0.46370385
123	BRSK1	0.45491619
124	PRKCA	0.45053333
125	MAPKAPK2	0.43993395
126	DAPK3	0.42679976
127	PRKACG	0.40019981
128	TNIK	0.39925925
129	AKT2	0.39099175
130	CSF1R	0.39030618
131	PDK1	0.38253170
132	MAP3K5	0.37824810
133	RET	0.35868068
134	PDK2	0.35535250
135	SRC	0.34319835
136	DAPK1	0.32435726
137	PRKCZ	0.32435329
138	PRKCI	0.32264896
139	EPHB1	0.32239234
140	AKT3	0.31661794
141	MAP2K1	0.30518201
142	PTK2	0.27818095
143	NUAK1	0.24612020
144	IRAK1	0.23429485
145	CAMK2G	0.20996875
146	CDK11A	0.20528912
147	PBK	0.20459752
148	CSNK1A1	0.19650534
149	VRK2	0.18609397
150	PRKCD	0.16855811

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	3.81859885
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.13622921
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.97804542
4	Fatty acid degradation_Homo sapiens_hsa00071	2.89498550
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.66771907
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.31097302
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.20595832
8	Caffeine metabolism_Homo sapiens_hsa00232	2.16380814
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.16206851
10	Fat digestion and absorption_Homo sapiens_hsa04975	2.16119848
11	Propanoate metabolism_Homo sapiens_hsa00640	2.14491885
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.08981674
13	Carbon metabolism_Homo sapiens_hsa01200	2.04683984
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.00838158
15	Protein digestion and absorption_Homo sapiens_hsa04974	1.94616603
16	Arginine biosynthesis_Homo sapiens_hsa00220	1.89026293
17	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.87761038
18	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.87235020
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.77360385
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.77041198
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.71438255
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.69357017
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.63580904
24	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.60900877
25	Folate biosynthesis_Homo sapiens_hsa00790	1.57838797
26	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.56601557
27	ABC transporters_Homo sapiens_hsa02010	1.53813617
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.51193681
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.48943015
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.47359560
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45139710
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.43666029
33	Sulfur relay system_Homo sapiens_hsa04122	1.41616672
34	Peroxisome_Homo sapiens_hsa04146	1.39091676
35	Sulfur metabolism_Homo sapiens_hsa00920	1.36071483
36	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.35974042
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.25632608
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.23721631
39	Galactose metabolism_Homo sapiens_hsa00052	1.23030502
40	Bile secretion_Homo sapiens_hsa04976	1.22570744
41	Butanoate metabolism_Homo sapiens_hsa00650	1.18990660
42	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.18723903
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16702762
44	Histidine metabolism_Homo sapiens_hsa00340	1.16107872
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.13874834
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13792043
47	Glutathione metabolism_Homo sapiens_hsa00480	1.13595935
48	Pentose phosphate pathway_Homo sapiens_hsa00030	1.12554882
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12085380
50	Complement and coagulation cascades_Homo sapiens_hsa04610	1.11200047
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09542634
52	DNA replication_Homo sapiens_hsa03030	1.08577350
53	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05028119
54	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04098293
55	One carbon pool by folate_Homo sapiens_hsa00670	1.02415608
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94983644
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94952941
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90098257
59	Lysine degradation_Homo sapiens_hsa00310	0.90090967
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88983562
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87919105
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85612546
63	Parkinsons disease_Homo sapiens_hsa05012	0.80807178
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80631473
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.73059099
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71201384
67	Other glycan degradation_Homo sapiens_hsa00511	0.70540705
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.70097204
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.69289649
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67358116
71	Fatty acid elongation_Homo sapiens_hsa00062	0.67216511
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66945636
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.64547895
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60767793
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60454061
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58162679
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.57866607
78	Metabolic pathways_Homo sapiens_hsa01100	0.57270949
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55862948
80	Insulin resistance_Homo sapiens_hsa04931	0.55237294
81	Pancreatic secretion_Homo sapiens_hsa04972	0.54702188
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54601654
83	Asthma_Homo sapiens_hsa05310	0.53490333
84	Retinol metabolism_Homo sapiens_hsa00830	0.52465764
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51796154
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51383804
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.50262926
88	Mineral absorption_Homo sapiens_hsa04978	0.47963447
89	Oxidative phosphorylation_Homo sapiens_hsa00190	0.46398926
90	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.44572376
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43998332
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42172201
93	Base excision repair_Homo sapiens_hsa03410	0.41774618
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38374703
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.35511431
96	Viral carcinogenesis_Homo sapiens_hsa05203	0.32910354
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.31854491
98	Alzheimers disease_Homo sapiens_hsa05010	0.30794856
99	Herpes simplex infection_Homo sapiens_hsa05168	0.30136647
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28732359
101	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28229909
102	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.28023833
103	Alcoholism_Homo sapiens_hsa05034	0.27407688
104	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27193925
105	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26750832
106	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26175809
107	Ribosome_Homo sapiens_hsa03010	0.24831886
108	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.24601182
109	Huntingtons disease_Homo sapiens_hsa05016	0.24514571
110	Apoptosis_Homo sapiens_hsa04210	0.24042393
111	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22821491
112	Bladder cancer_Homo sapiens_hsa05219	0.22505498
113	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.21119718
114	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.20724542
115	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.20091640
116	Mismatch repair_Homo sapiens_hsa03430	0.16699480
117	Renin secretion_Homo sapiens_hsa04924	0.11463008
118	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.08898689
119	Hepatitis C_Homo sapiens_hsa05160	0.07471803
120	Tight junction_Homo sapiens_hsa04530	0.06766319
121	Allograft rejection_Homo sapiens_hsa05330	0.06370996
122	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.06317103
123	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.03215646
124	Cocaine addiction_Homo sapiens_hsa05030	0.03131030
125	GnRH signaling pathway_Homo sapiens_hsa04912	-0.0895882
126	Thyroid cancer_Homo sapiens_hsa05216	-0.0724220
127	Graft-versus-host disease_Homo sapiens_hsa05332	-0.0695490
128	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0370261
129	Insulin secretion_Homo sapiens_hsa04911	-0.0152668

DHRS11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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