DHRS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)5.69188054
2regulation of vacuole organization (GO:0044088)5.03273485
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94284973
4protein localization to cilium (GO:0061512)4.93412412
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91148260
6negative regulation of cell killing (GO:0031342)4.91148260
7positive regulation of gamma-delta T cell activation (GO:0046645)4.55031221
8neutrophil activation involved in immune response (GO:0002283)4.15560528
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14032231
10modulation by symbiont of host defense response (GO:0052031)4.08203318
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08203318
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08203318
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.08203318
14modulation by symbiont of host immune response (GO:0052553)4.08203318
15positive regulation by symbiont of host defense response (GO:0052509)4.08203318
16antigen processing and presentation of endogenous antigen (GO:0019883)4.07374535
17negative regulation of granulocyte differentiation (GO:0030853)4.06687865
18activated T cell proliferation (GO:0050798)4.05497540
19keratinocyte development (GO:0003334)3.98259483
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74995936
21negative regulation of gluconeogenesis (GO:0045721)3.63607288
22regulation of B cell receptor signaling pathway (GO:0050855)3.62005794
23immunoglobulin mediated immune response (GO:0016064)3.60805329
24detection of other organism (GO:0098543)3.57720649
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55556951
26macrophage activation involved in immune response (GO:0002281)3.51248957
27response to host immune response (GO:0052572)3.43341504
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43341504
29regulation of gamma-delta T cell activation (GO:0046643)3.42831336
30positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.42235667
31detection of bacterium (GO:0016045)3.40224241
32neutrophil mediated immunity (GO:0002446)3.36438613
33respiratory burst (GO:0045730)3.27526597
34negative regulation of glycoprotein biosynthetic process (GO:0010561)3.26857066
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.26251146
36negative regulation of interleukin-12 production (GO:0032695)3.24074838
37neutrophil activation (GO:0042119)3.21407877
38leukocyte migration involved in inflammatory response (GO:0002523)3.20117907
39leukocyte aggregation (GO:0070486)3.20031384
40response to peptidoglycan (GO:0032494)3.19438070
41cellular response to type I interferon (GO:0071357)3.18339642
42type I interferon signaling pathway (GO:0060337)3.18339642
43centrosome localization (GO:0051642)3.18234869
44regulation of gamma-delta T cell differentiation (GO:0045586)3.15638866
45response to type I interferon (GO:0034340)3.14651965
46detection of molecule of bacterial origin (GO:0032490)3.13871557
47positive thymic T cell selection (GO:0045059)3.11644313
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11510091
49response to host (GO:0075136)3.11510091
50response to host defenses (GO:0052200)3.11510091
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10903040
52detection of external biotic stimulus (GO:0098581)3.10502667
53microglial cell activation (GO:0001774)3.09351051
54positive regulation of insulin receptor signaling pathway (GO:0046628)3.03351500
55negative regulation of innate immune response (GO:0045824)3.00920535
56negative regulation of cAMP-mediated signaling (GO:0043951)2.98285779
57response to interleukin-15 (GO:0070672)2.97853272
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94522683
59adaptation of signaling pathway (GO:0023058)2.92089543
60response to muramyl dipeptide (GO:0032495)2.90706141
61regulation of granulocyte differentiation (GO:0030852)2.90489497
62cellular extravasation (GO:0045123)2.89843093
63positive regulation of B cell differentiation (GO:0045579)2.85532396
64negative regulation of leukocyte mediated immunity (GO:0002704)2.84682291
65myeloid leukocyte mediated immunity (GO:0002444)2.84451279
66negative regulation of interleukin-6 production (GO:0032715)2.81709061
67regulation of protein polyubiquitination (GO:1902914)2.81525222
68myeloid cell activation involved in immune response (GO:0002275)2.80300691
69regulation of regulatory T cell differentiation (GO:0045589)2.79421328
70granulocyte activation (GO:0036230)2.79132841
71actin filament polymerization (GO:0030041)2.78908446
72cellular response to interleukin-15 (GO:0071350)2.78832383
73macrophage activation (GO:0042116)2.77578499
74SMAD protein complex assembly (GO:0007183)2.76284155
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73549164
76interferon-gamma-mediated signaling pathway (GO:0060333)2.71898394
77regulation of T cell mediated cytotoxicity (GO:0001914)2.71637518
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71239849
79negative regulation of T-helper cell differentiation (GO:0045623)2.71239849
80B cell receptor signaling pathway (GO:0050853)2.70129726
81response to interferon-beta (GO:0035456)2.69186109
82negative thymic T cell selection (GO:0045060)2.68631002
83regulation of B cell differentiation (GO:0045577)2.68433226
84detection of biotic stimulus (GO:0009595)2.67824882
85regulation of interleukin-6 biosynthetic process (GO:0045408)2.65882330
86negative regulation of T cell mediated immunity (GO:0002710)2.65014956
87negative regulation of glycoprotein metabolic process (GO:1903019)2.64940752
88interferon-gamma production (GO:0032609)2.61848615
89negative T cell selection (GO:0043383)2.61586563
90positive T cell selection (GO:0043368)2.59361621
91hydrogen peroxide biosynthetic process (GO:0050665)2.58267590
92regulation of interferon-beta biosynthetic process (GO:0045357)2.55712694
93negative regulation of alpha-beta T cell activation (GO:0046636)2.54133390
94xenobiotic catabolic process (GO:0042178)2.53874716
95positive regulation of mast cell activation (GO:0033005)2.53629708
96tolerance induction (GO:0002507)2.53547492
97defense response to protozoan (GO:0042832)2.52842942
98germinal center formation (GO:0002467)2.52451893
99autophagic vacuole fusion (GO:0000046)2.51864870
100negative regulation of cytokine production involved in immune response (GO:0002719)2.51632200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.63498401
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42918317
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31325791
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.29085487
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82566667
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71336511
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50330296
8EZH2_22144423_ChIP-Seq_EOC_Human2.50291514
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.50254122
10GATA1_22025678_ChIP-Seq_K562_Human2.38212612
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35629878
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.32287530
13RUNX_20019798_ChIP-Seq_JUKART_Human2.23014302
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22979930
15MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.09394793
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05118147
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95107658
18VDR_21846776_ChIP-Seq_THP-1_Human1.94468798
19SPI1_23127762_ChIP-Seq_K562_Human1.93737812
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93197218
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90770539
22SPI1_23547873_ChIP-Seq_NB4_Human1.88554342
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87475368
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84526954
25* UTX_26944678_Chip-Seq_JUKART_Human1.80884754
26MYB_26560356_Chip-Seq_TH2_Human1.79068824
27MAF_26560356_Chip-Seq_TH1_Human1.75944096
28MAF_26560356_Chip-Seq_TH2_Human1.75148140
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73480559
30VDR_24763502_ChIP-Seq_THP-1_Human1.72050090
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72036112
32* MYB_26560356_Chip-Seq_TH1_Human1.65845318
33GATA3_27048872_Chip-Seq_THYMUS_Human1.58173674
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53802365
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50521545
36BCL6_27268052_Chip-Seq_Bcells_Human1.48752100
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.48500310
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47429943
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46981893
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.45527323
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40955301
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40497367
43PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39309531
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37760648
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37260156
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36975206
47VDR_24787735_ChIP-Seq_THP-1_Human1.36925259
48GATA3_26560356_Chip-Seq_TH2_Human1.35145122
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33187653
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33095213
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32298197
52BCOR_27268052_Chip-Seq_Bcells_Human1.31260132
53KDM2B_26808549_Chip-Seq_DND41_Human1.30749472
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29441760
55SCL_19346495_ChIP-Seq_HPC-7_Human1.28290075
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27889122
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27315254
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27195871
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26549424
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24882995
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22830381
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.22625427
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19176800
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15031586
65LXR_22292898_ChIP-Seq_THP-1_Human1.14719467
66TCF7_22412390_ChIP-Seq_EML_Mouse1.11663234
67RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10448063
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08801411
69E2F1_20622854_ChIP-Seq_HELA_Human1.08341715
70P68_20966046_ChIP-Seq_HELA_Human1.08256759
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07503917
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07340936
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07044106
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06837531
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.05865668
76STAT1_20625510_ChIP-Seq_HELA_Human1.05701003
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04326212
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04309580
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04233094
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03975143
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03634533
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03614733
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02942111
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02396713
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01963967
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01704819
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01572373
88SPI1_20517297_ChIP-Seq_HL60_Human1.01547849
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01211334
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.01043638
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00532566
92P300_27268052_Chip-Seq_Bcells_Human0.99693520
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99020210
94ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93987467
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.93427425
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93347808
97SMRT_27268052_Chip-Seq_Bcells_Human0.92012309
98PU_27001747_Chip-Seq_BMDM_Mouse0.90503765
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90236762
100* NANOG_20526341_ChIP-Seq_ESCs_Human0.90060370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.93298489
2MP0003436_decreased_susceptibility_to3.61428495
3MP0003303_peritoneal_inflammation2.89633157
4MP0001835_abnormal_antigen_presentation2.88905839
5MP0002419_abnormal_innate_immunity2.65720092
6MP0009278_abnormal_bone_marrow2.47494101
7MP0001800_abnormal_humoral_immune2.45539253
8MP0005025_abnormal_response_to2.39754280
9MP0001790_abnormal_immune_system2.39231523
10MP0005387_immune_system_phenotype2.39231523
11MP0005000_abnormal_immune_tolerance2.36180127
12MP0002723_abnormal_immune_serum2.26577611
13MP0009785_altered_susceptibility_to2.22381344
14MP0000685_abnormal_immune_system2.22260865
15MP0002148_abnormal_hypersensitivity_rea2.19309901
16MP0002420_abnormal_adaptive_immunity2.17200993
17MP0001819_abnormal_immune_cell2.14119093
18MP0005671_abnormal_response_to2.13765104
19MP0003183_abnormal_peptide_metabolism2.11751356
20MP0002452_abnormal_antigen_presenting2.08838808
21MP0001986_abnormal_taste_sensitivity1.99868519
22MP0001533_abnormal_skeleton_physiology1.97482308
23MP0006082_CNS_inflammation1.80286281
24MP0002132_abnormal_respiratory_system1.78431830
25MP0001545_abnormal_hematopoietic_system1.77860451
26MP0005397_hematopoietic_system_phenotyp1.77860451
27MP0002405_respiratory_system_inflammati1.72212752
28MP0003172_abnormal_lysosome_physiology1.68111760
29MP0003763_abnormal_thymus_physiology1.67338586
30MP0003300_gastrointestinal_ulcer1.65501557
31MP0005464_abnormal_platelet_physiology1.63411915
32MP0003191_abnormal_cellular_cholesterol1.60220782
33MP0001845_abnormal_inflammatory_respons1.58726167
34MP0000716_abnormal_immune_system1.58414053
35MP0003195_calcinosis1.52833871
36MP0009764_decreased_sensitivity_to1.51438550
37MP0000689_abnormal_spleen_morphology1.50275499
38MP0008469_abnormal_protein_level1.49818020
39MP0002398_abnormal_bone_marrow1.46269744
40MP0002876_abnormal_thyroid_physiology1.44234333
41MP0002653_abnormal_ependyma_morphology1.43262163
42MP0005058_abnormal_lysosome_morphology1.36629211
43MP0002277_abnormal_respiratory_mucosa1.34789522
44MP0002722_abnormal_immune_system1.28229789
45MP0003787_abnormal_imprinting1.27444345
46MP0010155_abnormal_intestine_physiology1.27045702
47MP0003828_pulmonary_edema1.23333212
48MP0004883_abnormal_blood_vessel1.22976456
49MP0004381_abnormal_hair_follicle1.21941355
50MP0000343_altered_response_to1.20600204
51MP0004142_abnormal_muscle_tone1.19648988
52MP0006035_abnormal_mitochondrial_morpho1.19080688
53MP0005310_abnormal_salivary_gland1.18533211
54MP0000465_gastrointestinal_hemorrhage1.17223442
55MP0005075_abnormal_melanosome_morpholog1.16913280
56MP0000604_amyloidosis1.15419713
57MP0002429_abnormal_blood_cell1.15293699
58MP0003806_abnormal_nucleotide_metabolis1.12842337
59MP0008877_abnormal_DNA_methylation1.09612780
60MP0004130_abnormal_muscle_cell1.09351641
61MP0003866_abnormal_defecation1.06523563
62MP0005365_abnormal_bile_salt1.06175698
63MP0003075_altered_response_to1.05198913
64MP0004484_altered_response_of1.05039671
65MP0005535_abnormal_body_temperature1.04296722
66MP0010329_abnormal_lipoprotein_level1.03988012
67MP0005083_abnormal_biliary_tract1.02570923
68MP0003329_amyloid_beta_deposits0.99872447
69MP0000703_abnormal_thymus_morphology0.98433838
70MP0003878_abnormal_ear_physiology0.98356593
71MP0005377_hearing/vestibular/ear_phenot0.98356593
72MP0009840_abnormal_foam_cell0.96181841
73MP0004947_skin_inflammation0.93850118
74MP0002909_abnormal_adrenal_gland0.93841738
75MP0009765_abnormal_xenobiotic_induced0.91167280
76MP0001663_abnormal_digestive_system0.91083416
77MP0005319_abnormal_enzyme/_coenzyme0.89613760
78MP0002971_abnormal_brown_adipose0.89289142
79MP0002837_dystrophic_cardiac_calcinosis0.87724028
80MP0008875_abnormal_xenobiotic_pharmacok0.86823715
81MP0002928_abnormal_bile_duct0.86149700
82MP0003011_delayed_dark_adaptation0.85374646
83MP0005166_decreased_susceptibility_to0.84930020
84MP0002118_abnormal_lipid_homeostasis0.83951403
85MP0005390_skeleton_phenotype0.81155284
86MP0002102_abnormal_ear_morphology0.81029118
87MP0008260_abnormal_autophagy0.80306293
88MP0008004_abnormal_stomach_pH0.79779295
89MP0002933_joint_inflammation0.78615673
90MP0009763_increased_sensitivity_to0.76942845
91MP0002693_abnormal_pancreas_physiology0.76162499
92MP0006036_abnormal_mitochondrial_physio0.75282057
93MP0004510_myositis0.72455442
94MP0000015_abnormal_ear_pigmentation0.72324531
95MP0005164_abnormal_response_to0.72292582
96MP0001851_eye_inflammation0.71774411
97MP0005174_abnormal_tail_pigmentation0.71755183
98MP0002166_altered_tumor_susceptibility0.71126967
99MP0005084_abnormal_gallbladder_morpholo0.70384544
100MP0003690_abnormal_glial_cell0.69772792

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.23390026
2Elevated erythrocyte sedimentation rate (HP:0003565)4.83613705
3Myositis (HP:0100614)4.71277807
4Orchitis (HP:0100796)4.39454147
5Stomatitis (HP:0010280)4.33288893
6Recurrent abscess formation (HP:0002722)4.20999262
7Recurrent gram-negative bacterial infections (HP:0005420)4.18033050
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.13084225
9Optic neuritis (HP:0100653)4.08403153
10Retrobulbar optic neuritis (HP:0100654)4.08403153
11Recurrent bacterial skin infections (HP:0005406)4.08066248
12Abnormality of macrophages (HP:0004311)3.95580505
13Chronic obstructive pulmonary disease (HP:0006510)3.65260452
14Obstructive lung disease (HP:0006536)3.65260452
15Mediastinal lymphadenopathy (HP:0100721)3.45735380
16Recurrent fungal infections (HP:0002841)3.44405217
17Increased IgM level (HP:0003496)3.38064586
18Hypochromic microcytic anemia (HP:0004840)3.27631851
19Panhypogammaglobulinemia (HP:0003139)3.22381965
20Encephalitis (HP:0002383)3.20866234
21Episodic fever (HP:0001954)3.15044855
22Gastrointestinal infarctions (HP:0005244)3.08069933
23Recurrent cutaneous fungal infections (HP:0011370)3.06334566
24Chronic mucocutaneous candidiasis (HP:0002728)3.06334566
25Recurrent skin infections (HP:0001581)2.98880527
26Meningitis (HP:0001287)2.95642414
27Hypochromic anemia (HP:0001931)2.86444377
28Progressive neurologic deterioration (HP:0002344)2.85437641
29Acute hepatic failure (HP:0006554)2.69336626
30Keratoconjunctivitis sicca (HP:0001097)2.68422215
31Vasculitis (HP:0002633)2.66052781
32Urticaria (HP:0001025)2.64817940
33Petechiae (HP:0000967)2.61141384
34Brushfield spots (HP:0001088)2.57914669
35Infantile muscular hypotonia (HP:0008947)2.53273282
36Increased IgE level (HP:0003212)2.52427386
37Prolonged bleeding time (HP:0003010)2.51354147
38Keratoconjunctivitis (HP:0001096)2.50133862
39Gingival bleeding (HP:0000225)2.48059848
40Hemoptysis (HP:0002105)2.37449396
41Prolonged neonatal jaundice (HP:0006579)2.36311723
42Chest pain (HP:0100749)2.33814886
43Pulmonary embolism (HP:0002204)2.31726079
44Arterial thrombosis (HP:0004420)2.29393282
45Inflammation of the large intestine (HP:0002037)2.28042329
46Gingivitis (HP:0000230)2.26739440
47Spontaneous hematomas (HP:0007420)2.26220401
48Agammaglobulinemia (HP:0004432)2.21452484
49Pulmonary infiltrates (HP:0002113)2.17422829
50Chronic otitis media (HP:0000389)2.16644245
51Abnormality of T cell physiology (HP:0011840)2.16638818
52Colitis (HP:0002583)2.14238042
53Leukocytosis (HP:0001974)2.12806268
54Abnormality of T cells (HP:0002843)2.12477245
55Gastrointestinal inflammation (HP:0004386)2.11188168
56Systemic lupus erythematosus (HP:0002725)2.10572927
57Epistaxis (HP:0000421)2.09646369
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09128631
59Abnormality of polysaccharide metabolism (HP:0011012)2.09128631
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09128631
61Visual hallucinations (HP:0002367)2.05863164
62Hematochezia (HP:0002573)2.04594536
63Abnormality of transition element cation homeostasis (HP:0011030)2.02560651
64Hypergammaglobulinemia (HP:0010702)2.01985380
65Anorexia (HP:0002039)2.01052612
66Loss of speech (HP:0002371)2.00442220
67Granulocytopenia (HP:0001913)1.98510948
68Purpura (HP:0000979)1.98490338
69Urinary glycosaminoglycan excretion (HP:0003541)1.95505575
70Mucopolysacchariduria (HP:0008155)1.95505575
71Cellulitis (HP:0100658)1.95147841
72Choroideremia (HP:0001139)1.94650486
73Pustule (HP:0200039)1.92443553
74Severe visual impairment (HP:0001141)1.92289986
75Osteomyelitis (HP:0002754)1.90337317
76Dysostosis multiplex (HP:0000943)1.89665835
77Amyloidosis (HP:0011034)1.89651953
78Acne (HP:0001061)1.89404399
79Keratitis (HP:0000491)1.89323794
80Abnormal rod and cone electroretinograms (HP:0008323)1.88529202
81Microcytic anemia (HP:0001935)1.88398919
82Abnormality of the pleura (HP:0002103)1.88059671
83Recurrent sinusitis (HP:0011108)1.87878553
84Abnormality of glycosphingolipid metabolism (HP:0004343)1.87209369
85Abnormality of glycolipid metabolism (HP:0010969)1.87209369
86Abnormality of liposaccharide metabolism (HP:0010968)1.87209369
87Lissencephaly (HP:0001339)1.86172787
88Gangrene (HP:0100758)1.86051035
89Increased serum ferritin (HP:0003281)1.85829472
90Absent/shortened dynein arms (HP:0200106)1.85609165
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.85609165
92Alveolar cell carcinoma (HP:0006519)1.84955589
93Abnormality of iron homeostasis (HP:0011031)1.84883810
94Abnormality of T cell number (HP:0011839)1.81191574
95Stomach cancer (HP:0012126)1.80954023
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77252382
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76810752
98Abnormality of the pericardium (HP:0001697)1.76645905
99Polyneuropathy (HP:0001271)1.75837369
100Viral hepatitis (HP:0006562)1.73518058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.20694355
2MAP2K33.13084961
3FES2.85646140
4IRAK42.51677294
5CSK2.26737860
6MAP3K132.25636594
7TAOK32.25526144
8RIPK42.19682501
9ERN12.18315849
10PRPF4B2.18118834
11MAP3K112.13411895
12MAP3K72.10921893
13TAOK12.07710623
14TXK2.06339281
15TYK22.05464976
16GRK61.97013270
17BLK1.95984612
18TNK21.94855697
19MAP3K91.91126280
20MAP3K31.87455212
21BTK1.82693518
22TAOK21.75164861
23ZAP701.62767441
24MOS1.62087904
25SYK1.60671806
26TGFBR21.52052424
27IKBKE1.49208990
28BCKDK1.47619742
29HIPK21.45795252
30IKBKB1.39860500
31MAP3K11.39227091
32KSR21.35640955
33TBK11.34922420
34KIT1.34653955
35NME11.28981248
36EPHB11.26792097
37MATK1.26304816
38FRK1.25373920
39JAK31.20969962
40LRRK21.20452783
41LYN1.18464268
42NLK1.18270429
43MAP3K141.16245478
44TEC1.16063387
45JAK21.15001827
46PRKD21.12937596
47DYRK1B1.09834772
48ITK1.09325030
49HCK1.08650851
50TYRO31.07848316
51MARK21.06046516
52ARAF1.05542560
53LCK1.04326330
54MAP2K60.99818208
55JAK10.97407318
56MAP2K20.96609881
57FGR0.84968751
58PAK60.84919778
59DAPK20.82456451
60GRK70.81272176
61STK110.81237648
62CSF1R0.80699220
63CAMKK20.78924363
64EPHA30.73914365
65STK380.72058456
66CDK190.70176640
67YES10.67130366
68PTK2B0.65457545
69MAP2K40.61640080
70RAF10.61639621
71PRKAA20.60833330
72PRKCQ0.57582968
73STK160.55165503
74MAPK150.52416088
75PDK10.51834874
76STK100.48285787
77GRK50.45404917
78MARK30.44507868
79SGK20.43706327
80PDPK10.43425563
81MAP3K60.43083069
82RPS6KC10.40977694
83RPS6KL10.40977694
84MAP3K50.40888387
85SGK2230.38545635
86SGK4940.38545635
87PRKD10.38297721
88CHUK0.37945493
89RPS6KA60.37356065
90SIK20.37232535
91PINK10.35196691
92FYN0.34522168
93PTK60.34487587
94SGK30.33569218
95PIM10.33338522
96CAMKK10.30469764
97TESK20.30356020
98SIK30.29541681
99PIK3CG0.29206853
100ADRBK10.29180161

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.16848831
2Leishmaniasis_Homo sapiens_hsa051402.94308223
3Osteoclast differentiation_Homo sapiens_hsa043802.80496327
4Primary immunodeficiency_Homo sapiens_hsa053402.55203965
5Allograft rejection_Homo sapiens_hsa053302.48549270
6Graft-versus-host disease_Homo sapiens_hsa053322.42092546
7Autoimmune thyroid disease_Homo sapiens_hsa053202.35953896
8Type I diabetes mellitus_Homo sapiens_hsa049402.30674163
9Tuberculosis_Homo sapiens_hsa051522.00390214
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87546607
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85204164
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85133605
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.80818481
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78705247
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73546149
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68444556
17B cell receptor signaling pathway_Homo sapiens_hsa046621.67967539
18Peroxisome_Homo sapiens_hsa041461.59901107
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59661851
20Asthma_Homo sapiens_hsa053101.56807591
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53358455
22Hematopoietic cell lineage_Homo sapiens_hsa046401.52482869
23T cell receptor signaling pathway_Homo sapiens_hsa046601.52323622
24Chemokine signaling pathway_Homo sapiens_hsa040621.46700287
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.45074451
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42550610
27Other glycan degradation_Homo sapiens_hsa005111.37592301
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.36382364
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.34734521
30Measles_Homo sapiens_hsa051621.34023968
31Malaria_Homo sapiens_hsa051441.27914349
32Antigen processing and presentation_Homo sapiens_hsa046121.25389769
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24462301
34Rheumatoid arthritis_Homo sapiens_hsa053231.20678114
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18556552
36Viral myocarditis_Homo sapiens_hsa054161.17467236
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15721952
38Acute myeloid leukemia_Homo sapiens_hsa052211.13724772
39Arachidonic acid metabolism_Homo sapiens_hsa005901.12540041
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12505287
41TNF signaling pathway_Homo sapiens_hsa046681.12326740
42Folate biosynthesis_Homo sapiens_hsa007901.09088457
43Herpes simplex infection_Homo sapiens_hsa051681.06001603
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.04383923
45Hepatitis C_Homo sapiens_hsa051601.04202221
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03987678
47Toxoplasmosis_Homo sapiens_hsa051451.02191372
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00075704
49Influenza A_Homo sapiens_hsa051640.97512872
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96417186
51Legionellosis_Homo sapiens_hsa051340.96367839
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96180675
53Phagosome_Homo sapiens_hsa041450.91756176
54Fatty acid degradation_Homo sapiens_hsa000710.90153638
55Pertussis_Homo sapiens_hsa051330.89320516
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89127072
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85547582
58Regulation of autophagy_Homo sapiens_hsa041400.84796016
59Platelet activation_Homo sapiens_hsa046110.84686174
60Lysosome_Homo sapiens_hsa041420.81395182
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80542005
62Linoleic acid metabolism_Homo sapiens_hsa005910.80207859
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.78193416
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.78191758
65Dorso-ventral axis formation_Homo sapiens_hsa043200.76465826
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.76252410
67Prolactin signaling pathway_Homo sapiens_hsa049170.71633205
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70823858
69African trypanosomiasis_Homo sapiens_hsa051430.70539026
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69457172
71VEGF signaling pathway_Homo sapiens_hsa043700.68513851
72Shigellosis_Homo sapiens_hsa051310.66236878
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.64817220
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62258657
75Salmonella infection_Homo sapiens_hsa051320.61471747
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57539880
77Chemical carcinogenesis_Homo sapiens_hsa052040.56408122
78Hepatitis B_Homo sapiens_hsa051610.55544506
79Complement and coagulation cascades_Homo sapiens_hsa046100.55070705
80Endocytosis_Homo sapiens_hsa041440.54159104
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54082873
82Apoptosis_Homo sapiens_hsa042100.47899009
83Glycerolipid metabolism_Homo sapiens_hsa005610.47492291
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47210948
85PPAR signaling pathway_Homo sapiens_hsa033200.47164707
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43533349
87Fatty acid elongation_Homo sapiens_hsa000620.43073573
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41714881
89Butanoate metabolism_Homo sapiens_hsa006500.41555713
90FoxO signaling pathway_Homo sapiens_hsa040680.41195412
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39671811
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39432373
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37924065
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37416351
95Sphingolipid metabolism_Homo sapiens_hsa006000.35768485
96Fatty acid metabolism_Homo sapiens_hsa012120.35519182
97Notch signaling pathway_Homo sapiens_hsa043300.34604631
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.33510041
99Insulin resistance_Homo sapiens_hsa049310.32605270
100Collecting duct acid secretion_Homo sapiens_hsa049660.32308008

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