DHRS13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.85672766
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14681976
3protoporphyrinogen IX biosynthetic process (GO:0006782)5.01167429
4oxygen transport (GO:0015671)4.93232817
5peptidyl-arginine omega-N-methylation (GO:0035247)4.65829723
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60126438
7ATP synthesis coupled proton transport (GO:0015986)4.60126438
8negative regulation of erythrocyte differentiation (GO:0045647)4.34173573
9formation of translation preinitiation complex (GO:0001731)4.29949513
10maturation of SSU-rRNA (GO:0030490)4.26928556
11histone arginine methylation (GO:0034969)4.26114633
12viral transcription (GO:0019083)4.20029983
13translational termination (GO:0006415)4.19289076
14negative regulation of microtubule polymerization (GO:0031115)4.14556763
15erythrocyte maturation (GO:0043249)4.10489742
16porphyrin-containing compound biosynthetic process (GO:0006779)4.10135061
17gas transport (GO:0015669)4.06022253
18response to pheromone (GO:0019236)4.05547581
19intracellular estrogen receptor signaling pathway (GO:0030520)4.00543842
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.99106243
21peptidyl-arginine N-methylation (GO:0035246)3.97211578
22peptidyl-arginine methylation (GO:0018216)3.97211578
23DNA strand elongation involved in DNA replication (GO:0006271)3.96633968
24positive regulation of gamma-delta T cell activation (GO:0046645)3.95857885
25positive regulation by symbiont of host defense response (GO:0052509)3.90953779
26modulation by symbiont of host defense response (GO:0052031)3.90953779
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90953779
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90953779
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.90953779
30modulation by symbiont of host immune response (GO:0052553)3.90953779
31translational initiation (GO:0006413)3.86680354
32ribosomal small subunit biogenesis (GO:0042274)3.83044658
33spliceosomal snRNP assembly (GO:0000387)3.81650808
34translational elongation (GO:0006414)3.81190262
35DNA replication initiation (GO:0006270)3.80377773
36nucleobase biosynthetic process (GO:0046112)3.80337297
37folic acid-containing compound biosynthetic process (GO:0009396)3.79632060
38chaperone-mediated protein transport (GO:0072321)3.77145109
393-UTR-mediated mRNA stabilization (GO:0070935)3.76675637
40DNA unwinding involved in DNA replication (GO:0006268)3.76002678
41heme biosynthetic process (GO:0006783)3.74814174
42proteasome assembly (GO:0043248)3.73512907
43DNA strand elongation (GO:0022616)3.72001354
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70365397
45leukocyte aggregation (GO:0070486)3.68568974
46leukocyte migration involved in inflammatory response (GO:0002523)3.67201067
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64365905
48regulation of mitochondrial translation (GO:0070129)3.62497214
49ribosomal large subunit biogenesis (GO:0042273)3.59948039
50respiratory burst (GO:0045730)3.59713797
51de novo posttranslational protein folding (GO:0051084)3.56976657
52tetrapyrrole biosynthetic process (GO:0033014)3.53288453
53de novo protein folding (GO:0006458)3.52271926
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.50708030
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49047256
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48989551
57cellular protein complex disassembly (GO:0043624)3.48391999
58telomere maintenance via semi-conservative replication (GO:0032201)3.48071557
59cullin deneddylation (GO:0010388)3.46320092
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44866283
61negative regulation of cell killing (GO:0031342)3.44866283
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43945028
63detection of bacterium (GO:0016045)3.42796576
64detection of other organism (GO:0098543)3.42484956
65ribonucleoprotein complex biogenesis (GO:0022613)3.41539007
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41494401
67negative regulation of ligase activity (GO:0051352)3.41494401
68folic acid metabolic process (GO:0046655)3.39288924
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39157327
70pyrimidine nucleobase catabolic process (GO:0006208)3.38724332
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38099670
72cotranslational protein targeting to membrane (GO:0006613)3.36814132
73purine nucleobase biosynthetic process (GO:0009113)3.36813972
74viral life cycle (GO:0019058)3.35695464
75protein insertion into membrane (GO:0051205)3.33481669
76response to peptidoglycan (GO:0032494)3.32833291
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32229068
78protein targeting to ER (GO:0045047)3.31955068
79ribosome biogenesis (GO:0042254)3.31605462
80protein deneddylation (GO:0000338)3.30497271
81porphyrin-containing compound metabolic process (GO:0006778)3.30181738
82neutrophil activation involved in immune response (GO:0002283)3.29931836
83DNA deamination (GO:0045006)3.26630948
84ribosomal small subunit assembly (GO:0000028)3.21435499
85erythrocyte development (GO:0048821)3.21325122
86rRNA processing (GO:0006364)3.20647342
87translation (GO:0006412)3.20388152
88establishment of protein localization to mitochondrion (GO:0072655)3.20353502
89regulation of cellular amino acid metabolic process (GO:0006521)3.19990070
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16804319
91DNA replication-dependent nucleosome assembly (GO:0006335)3.16680686
92DNA replication-dependent nucleosome organization (GO:0034723)3.16680686
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16514991
94protein complex disassembly (GO:0043241)3.16241074
95protein localization to endoplasmic reticulum (GO:0070972)3.15370084
96pentose-phosphate shunt (GO:0006098)3.11463398
97protein targeting to mitochondrion (GO:0006626)3.11021544
98regulation of chromatin binding (GO:0035561)3.10021343
99rRNA metabolic process (GO:0016072)3.09734554
100macromolecular complex disassembly (GO:0032984)3.08304147
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07442857
102response to host immune response (GO:0052572)3.07442857
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05035251
104peptidyl-tyrosine autophosphorylation (GO:0038083)3.04272949
105response to interleukin-15 (GO:0070672)3.03428907
106nucleotide-excision repair, DNA gap filling (GO:0006297)3.02575878
107hemoglobin metabolic process (GO:0020027)3.01672925
108pentose metabolic process (GO:0019321)3.00504562
109guanosine-containing compound biosynthetic process (GO:1901070)2.99457889
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99379764
111cellular component biogenesis (GO:0044085)2.98456210
112proline biosynthetic process (GO:0006561)2.97897722
113regulation of gamma-delta T cell differentiation (GO:0045586)2.97765946
114heme metabolic process (GO:0042168)2.97047241
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95735432
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95735432
117megakaryocyte development (GO:0035855)2.95583718
118positive regulation of ligase activity (GO:0051351)2.92487632
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.92319911
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92319911
121neutrophil activation (GO:0042119)2.92262449
122inner mitochondrial membrane organization (GO:0007007)2.92231165
123establishment of integrated proviral latency (GO:0075713)2.91569340
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91487593
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91487593
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91487593
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91266155
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91266155
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89550326
130protein localization to mitochondrion (GO:0070585)2.88915091
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.88632448
132regulation of gamma-delta T cell activation (GO:0046643)2.88496238
133DNA replication checkpoint (GO:0000076)2.86510946
134modulation by virus of host process (GO:0019054)2.86384496
135telomere maintenance via recombination (GO:0000722)2.85625774
136DNA damage response, detection of DNA damage (GO:0042769)2.85227257
137oxidative phosphorylation (GO:0006119)2.84973432
138glucose 6-phosphate metabolic process (GO:0051156)2.84615414
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83819726
140pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83190569
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.82238544
142NADH dehydrogenase complex assembly (GO:0010257)2.82238544
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82238544
144pteridine-containing compound biosynthetic process (GO:0042559)2.81412934
145DNA topological change (GO:0006265)2.81298484
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81167392
147regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81093437
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.80682420
149spliceosomal complex assembly (GO:0000245)2.79199441
150NADPH regeneration (GO:0006740)2.78939770
151protein-DNA complex disassembly (GO:0032986)2.77391477
152nucleosome disassembly (GO:0006337)2.77391477
153myeloid cell development (GO:0061515)2.75198457
154dosage compensation (GO:0007549)2.74821263
155granulocyte differentiation (GO:0030851)2.74050902
156peptidyl-histidine modification (GO:0018202)2.73946855
157UTP biosynthetic process (GO:0006228)2.73754580
158cellular response to interleukin-15 (GO:0071350)2.69739669
159regulation of B cell receptor signaling pathway (GO:0050855)2.65983462
160negative regulation of lymphocyte mediated immunity (GO:0002707)2.65309177
161response to host defenses (GO:0052200)2.64855726
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64855726
163response to host (GO:0075136)2.64855726
164antigen processing and presentation of endogenous antigen (GO:0019883)2.64604370
165detection of external biotic stimulus (GO:0098581)2.64547486
166positive regulation of B cell differentiation (GO:0045579)2.63493353
167cellular response to interleukin-4 (GO:0071353)2.60001342
168macrophage activation involved in immune response (GO:0002281)2.59000135
169granulocyte activation (GO:0036230)2.58997562
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.56866190
171positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55565905
172spliceosomal tri-snRNP complex assembly (GO:0000244)2.53698120
173neutrophil mediated immunity (GO:0002446)2.52247225
174Peyers patch development (GO:0048541)2.50133536
175mucosal-associated lymphoid tissue development (GO:0048537)2.50133536
176antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49602913
177mRNA stabilization (GO:0048255)2.48908565
178RNA stabilization (GO:0043489)2.48908565
179peptidyl-arginine modification (GO:0018195)2.47687370
180cellular extravasation (GO:0045123)2.46543026
181leukocyte degranulation (GO:0043299)2.45638306
182GDP-mannose metabolic process (GO:0019673)2.45630840
183mitotic chromosome condensation (GO:0007076)2.44867223
184regulation of interferon-beta biosynthetic process (GO:0045357)2.44258903
185negative regulation of phagocytosis (GO:0050765)2.44130317
186cellular response to virus (GO:0098586)2.43270160
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.43102388
188regulation of mast cell degranulation (GO:0043304)2.42798253
189positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41702313
190positive regulation of granulocyte differentiation (GO:0030854)2.39722615
191regulation of erythrocyte differentiation (GO:0045646)2.39481986
192negative regulation of leukocyte mediated immunity (GO:0002704)2.37685014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.02846601
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.66328332
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.55792754
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50785747
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.48904061
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30244518
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.28751383
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27750783
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20749727
10VDR_21846776_ChIP-Seq_THP-1_Human3.00332404
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.99056919
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94538946
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74984934
14XRN2_22483619_ChIP-Seq_HELA_Human2.73938320
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71062672
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.68016836
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.61759475
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52368409
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40059423
20DCP1A_22483619_ChIP-Seq_HELA_Human2.33608810
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32227293
22TTF2_22483619_ChIP-Seq_HELA_Human2.23107490
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23000092
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21057950
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20178119
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19861669
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18553011
28GABP_19822575_ChIP-Seq_HepG2_Human2.16170611
29VDR_23849224_ChIP-Seq_CD4+_Human2.15245183
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11099266
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.07725287
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02367418
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01454630
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95697701
35FOXP3_21729870_ChIP-Seq_TREG_Human1.95159671
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94787469
37LXR_22292898_ChIP-Seq_THP-1_Human1.94368680
38MAF_26560356_Chip-Seq_TH1_Human1.87198183
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85506440
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85234334
41KDM2B_26808549_Chip-Seq_DND41_Human1.83983304
42SCL_19346495_ChIP-Seq_HPC-7_Human1.79319591
43AR_21909140_ChIP-Seq_LNCAP_Human1.79272414
44MAF_26560356_Chip-Seq_TH2_Human1.76693274
45TCF7_22412390_ChIP-Seq_EML_Mouse1.76441608
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71128104
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68089202
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.68041884
49* UTX_26944678_Chip-Seq_JUKART_Human1.67965729
50ZNF263_19887448_ChIP-Seq_K562_Human1.66857183
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66116623
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64565551
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62748532
54CIITA_25753668_ChIP-Seq_RAJI_Human1.61739404
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60849420
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60478576
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60143690
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58353871
59P68_20966046_ChIP-Seq_HELA_Human1.58304548
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58293409
61VDR_24763502_ChIP-Seq_THP-1_Human1.56055303
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.56000342
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54883778
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52859502
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52682471
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50941924
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.47984589
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47233069
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47169030
70RACK7_27058665_Chip-Seq_MCF-7_Human1.46241423
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45790148
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.44219483
73SPI1_23547873_ChIP-Seq_NB4_Human1.43802383
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43680503
75NCOR1_26117541_ChIP-Seq_K562_Human1.42953422
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42514683
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42210635
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41877593
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.39023659
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38008290
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36428897
82KDM5A_27292631_Chip-Seq_BREAST_Human1.36271699
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36230296
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.36007419
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35718749
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35469016
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.34112818
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33785894
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33157808
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31808139
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30839972
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30365592
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29956107
94BCL6_27268052_Chip-Seq_Bcells_Human1.28935022
95* GATA1_19941826_ChIP-Seq_K562_Human1.28378679
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.27889354
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27153517
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27050914
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.26249176
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26165746
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25825639
102MYC_22102868_ChIP-Seq_BL_Human1.25812331
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25775298
104BCOR_27268052_Chip-Seq_Bcells_Human1.25532346
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25090455
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24408101
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23360640
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.20459013
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16946774
110* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16539105
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16432741
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16277041
113CTCF_21964334_Chip-Seq_Bcells_Human1.14563307
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12568465
115SMC4_20622854_ChIP-Seq_HELA_Human1.12403481
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11993785
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11429784
118* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11359129
119MYB_26560356_Chip-Seq_TH1_Human1.11231732
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11198357
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09757714
122TFEB_21752829_ChIP-Seq_HELA_Human1.09676947
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08387326
124* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08060479
125ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08013643
126MYC_18940864_ChIP-ChIP_HL60_Human1.07612691
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07048526
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.06486352
129GATA1_22025678_ChIP-Seq_K562_Human1.05392199
130EGR1_19374776_ChIP-ChIP_THP-1_Human1.05179274
131ELK1_22589737_ChIP-Seq_MCF10A_Human1.04550989
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04472317
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03100705
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03075055
135NANOG_21062744_ChIP-ChIP_HESCs_Human1.02531226
136ELK1_19687146_ChIP-ChIP_HELA_Human0.99138993
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97405468
138* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97238560
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96621257
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96403984
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96122066
142* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95327690
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93260529
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92577683
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91096677
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89930751
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89395648
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87392269
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87258630
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87202432
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86499119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.01534609
2MP0004957_abnormal_blastocyst_morpholog3.40238166
3MP0005451_abnormal_body_composition3.20053486
4MP0003111_abnormal_nucleus_morphology3.17846014
5MP0003303_peritoneal_inflammation3.07107855
6MP0010094_abnormal_chromosome_stability2.93896271
7MP0008260_abnormal_autophagy2.76851895
8MP0009278_abnormal_bone_marrow2.72040391
9MP0006276_abnormal_autonomic_nervous2.66042487
10MP0003122_maternal_imprinting2.62401061
11MP0001984_abnormal_olfaction2.61075361
12MP0003077_abnormal_cell_cycle2.54069836
13MP0003436_decreased_susceptibility_to2.49366687
14MP0000537_abnormal_urethra_morphology2.47595674
15MP0003724_increased_susceptibility_to2.39530781
16MP0009379_abnormal_foot_pigmentation2.38898019
17MP0008058_abnormal_DNA_repair2.31815171
18MP0002132_abnormal_respiratory_system2.28212006
19MP0008932_abnormal_embryonic_tissue2.22939779
20MP0001529_abnormal_vocalization2.22096164
21MP0008057_abnormal_DNA_replication2.13794687
22MP0005397_hematopoietic_system_phenotyp2.09264198
23MP0001545_abnormal_hematopoietic_system2.09264198
24MP0003718_maternal_effect2.09174052
25MP0006072_abnormal_retinal_apoptosis2.08453651
26MP0002398_abnormal_bone_marrow1.95213813
27MP0002184_abnormal_innervation1.94656039
28MP0003121_genomic_imprinting1.94377484
29MP0005423_abnormal_somatic_nervous1.93127905
30MP0001730_embryonic_growth_arrest1.87676141
31MP0000465_gastrointestinal_hemorrhage1.85059456
32MP0003123_paternal_imprinting1.84792612
33MP0003763_abnormal_thymus_physiology1.84386908
34MP0009333_abnormal_splenocyte_physiolog1.83366820
35MP0005464_abnormal_platelet_physiology1.83099678
36MP0005025_abnormal_response_to1.82196984
37MP0002722_abnormal_immune_system1.81051184
38MP0000703_abnormal_thymus_morphology1.77403617
39MP0004858_abnormal_nervous_system1.73708339
40MP0004185_abnormal_adipocyte_glucose1.73095219
41MP0006035_abnormal_mitochondrial_morpho1.69662772
42MP0000350_abnormal_cell_proliferation1.69424314
43MP0002419_abnormal_innate_immunity1.68430132
44MP0005377_hearing/vestibular/ear_phenot1.67720175
45MP0003878_abnormal_ear_physiology1.67720175
46MP0000358_abnormal_cell_content/1.64652192
47MP0000689_abnormal_spleen_morphology1.61829532
48MP0002420_abnormal_adaptive_immunity1.61399309
49MP0001819_abnormal_immune_cell1.61042600
50MP0005645_abnormal_hypothalamus_physiol1.57975160
51MP0003890_abnormal_embryonic-extraembry1.56812646
52MP0001697_abnormal_embryo_size1.55233145
53MP0008789_abnormal_olfactory_epithelium1.55055683
54MP0003119_abnormal_digestive_system1.53589839
55MP0000685_abnormal_immune_system1.53311658
56MP0005499_abnormal_olfactory_system1.53184345
57MP0005394_taste/olfaction_phenotype1.53184345
58MP0002653_abnormal_ependyma_morphology1.52272824
59MP0001800_abnormal_humoral_immune1.48466846
60MP0002429_abnormal_blood_cell1.47964490
61MP0004133_heterotaxia1.44048030
62MP0005076_abnormal_cell_differentiation1.43672179
63MP0002080_prenatal_lethality1.43172826
64MP0009785_altered_susceptibility_to1.42750135
65MP0005000_abnormal_immune_tolerance1.41779281
66MP0000716_abnormal_immune_system1.41410207
67MP0002723_abnormal_immune_serum1.40881899
68MP0006036_abnormal_mitochondrial_physio1.40538206
69MP0001188_hyperpigmentation1.39427063
70MP0003786_premature_aging1.37078664
71MP0003861_abnormal_nervous_system1.32992803
72MP0000778_abnormal_nervous_system1.32651921
73MP0003656_abnormal_erythrocyte_physiolo1.32165795
74MP0003866_abnormal_defecation1.29734429
75MP0005671_abnormal_response_to1.28805789
76MP0010030_abnormal_orbit_morphology1.28058454
77MP0000631_abnormal_neuroendocrine_gland1.27718012
78MP0005380_embryogenesis_phenotype1.27576874
79MP0001672_abnormal_embryogenesis/_devel1.27576874
80MP0002085_abnormal_embryonic_tissue1.26667936
81MP0001835_abnormal_antigen_presentation1.26619348
82MP0003942_abnormal_urinary_system1.25584463
83MP0001968_abnormal_touch/_nociception1.23914445
84MP0002452_abnormal_antigen_presenting1.22743679
85MP0003221_abnormal_cardiomyocyte_apopto1.22641762
86MP0004215_abnormal_myocardial_fiber1.20987634
87MP0003329_amyloid_beta_deposits1.20279642
88MP0002084_abnormal_developmental_patter1.18317256
89MP0000678_abnormal_parathyroid_gland1.18093281
90MP0004264_abnormal_extraembryonic_tissu1.17998096
91MP0001790_abnormal_immune_system1.17705448
92MP0005387_immune_system_phenotype1.17705448
93MP0002822_catalepsy1.16702363
94MP0000534_abnormal_ureter_morphology1.15075270
95MP0003191_abnormal_cellular_cholesterol1.13163559
96MP0008007_abnormal_cellular_replicative1.13061274
97MP0005083_abnormal_biliary_tract1.12509627
98MP0002405_respiratory_system_inflammati1.10827041
99MP0002152_abnormal_brain_morphology1.10642165
100MP0003315_abnormal_perineum_morphology1.08788827
101MP0004808_abnormal_hematopoietic_stem1.08139004
102MP0003172_abnormal_lysosome_physiology1.07859172
103MP0002751_abnormal_autonomic_nervous1.07812098
104MP0002638_abnormal_pupillary_reflex1.07427769
105MP0002088_abnormal_embryonic_growth/wei1.06681644
106MP0000490_abnormal_crypts_of1.05616063
107MP0001293_anophthalmia1.05049517
108MP0004142_abnormal_muscle_tone1.04278488
109MP0003984_embryonic_growth_retardation1.04201171
110MP0002009_preneoplasia1.03497056
111MP0002736_abnormal_nociception_after1.03265486
112MP0002019_abnormal_tumor_incidence1.03149088
113MP0004947_skin_inflammation1.03032537
114MP0005551_abnormal_eye_electrophysiolog1.02993798
115MP0004197_abnormal_fetal_growth/weight/1.01635873
116MP0001905_abnormal_dopamine_level1.00821536
117MP0003635_abnormal_synaptic_transmissio1.00820055
118MP0002557_abnormal_social/conspecific_i1.00553751
119MP0005310_abnormal_salivary_gland1.00098213
120MP0004859_abnormal_synaptic_plasticity0.99754624
121MP0000313_abnormal_cell_death0.99537206
122MP0002277_abnormal_respiratory_mucosa0.99243707
123MP0003880_abnormal_central_pattern0.98892576
124MP0004233_abnormal_muscle_weight0.97701491
125MP0004147_increased_porphyrin_level0.95250820
126MP0004811_abnormal_neuron_physiology0.93823010
127MP0008770_decreased_survivor_rate0.92879887
128MP0000858_altered_metastatic_potential0.90346112
129MP0002733_abnormal_thermal_nociception0.89264203
130MP0003137_abnormal_impulse_conducting0.88906297
131MP0008995_early_reproductive_senescence0.88634945
132MP0001727_abnormal_embryo_implantation0.87383714
133MP0002063_abnormal_learning/memory/cond0.86924500
134MP0009840_abnormal_foam_cell0.86908680
135MP0002396_abnormal_hematopoietic_system0.86774893
136MP0002752_abnormal_somatic_nervous0.86207307
137MP0001849_ear_inflammation0.85979443
138MP0005666_abnormal_adipose_tissue0.85206742
139MP0005058_abnormal_lysosome_morphology0.85015709
140MP0003115_abnormal_respiratory_system0.84469656
141MP0004742_abnormal_vestibular_system0.84193505
142MP0002734_abnormal_mechanical_nocicepti0.84154003
143MP0000015_abnormal_ear_pigmentation0.83439438
144MP0004924_abnormal_behavior0.83383484
145MP0005386_behavior/neurological_phenoty0.83383484
146MP0003567_abnormal_fetal_cardiomyocyte0.83377728
147MP0005075_abnormal_melanosome_morpholog0.81914764
148MP0005501_abnormal_skin_physiology0.81675712
149MP0002882_abnormal_neuron_morphology0.81253054
150MP0009931_abnormal_skin_appearance0.80278498
151MP0001845_abnormal_inflammatory_respons0.80003807
152MP0008872_abnormal_physiological_respon0.79799664
153MP0002102_abnormal_ear_morphology0.79633350
154MP0002735_abnormal_chemical_nociception0.78742153
155MP0002081_perinatal_lethality0.77076019
156MP0001145_abnormal_male_reproductive0.76756326
157MP0005384_cellular_phenotype0.76581165
158MP0004381_abnormal_hair_follicle0.76525468
159MP0009672_abnormal_birth_weight0.76048434
160MP0002090_abnormal_vision0.75889890
161MP0010155_abnormal_intestine_physiology0.75598632
162MP0002210_abnormal_sex_determination0.75095033
163MP0001502_abnormal_circadian_rhythm0.72633743
164MP0000955_abnormal_spinal_cord0.71789862
165MP0010770_preweaning_lethality0.70653023
166MP0005410_abnormal_fertilization0.70532344
167MP0002166_altered_tumor_susceptibility0.69607503
168MP0008469_abnormal_protein_level0.69286497
169MP0001873_stomach_inflammation0.69201882
170MP0001851_eye_inflammation0.69157489
171MP0005621_abnormal_cell_physiology0.67710029

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.92493913
2Reticulocytosis (HP:0001923)4.42797741
3Hypochromic anemia (HP:0001931)4.33595074
4Eczematoid dermatitis (HP:0000976)4.15726234
5Cholecystitis (HP:0001082)4.08320881
6Abnormal gallbladder physiology (HP:0012438)4.08320881
7Abnormality of cells of the erythroid lineage (HP:0012130)4.01794694
8Recurrent abscess formation (HP:0002722)3.89806948
9Obstructive lung disease (HP:0006536)3.85063615
10Chronic obstructive pulmonary disease (HP:0006510)3.85063615
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.83261093
12Cholelithiasis (HP:0001081)3.73922966
13Abnormality of glycolysis (HP:0004366)3.73478344
14Increased serum pyruvate (HP:0003542)3.73478344
15Recurrent bacterial skin infections (HP:0005406)3.63916464
16Poikilocytosis (HP:0004447)3.49356920
17Microcytic anemia (HP:0001935)3.47377497
18Abnormal number of erythroid precursors (HP:0012131)3.44707508
19Abnormality of the labia minora (HP:0012880)3.37421272
20Abnormality of reticulocytes (HP:0004312)3.37281025
21Hypertensive crisis (HP:0100735)3.30767632
22Abnormal gallbladder morphology (HP:0012437)3.29352844
23Acute necrotizing encephalopathy (HP:0006965)3.27911668
24Cerebral hypomyelination (HP:0006808)3.25251506
25Stomatitis (HP:0010280)3.08819992
26Prolonged bleeding time (HP:0003010)3.08308533
27Petechiae (HP:0000967)3.05812429
28Gastrointestinal infarctions (HP:0005244)3.05439340
29Limb dystonia (HP:0002451)3.01323959
30Abnormal mitochondria in muscle tissue (HP:0008316)2.96218134
31Abnormal hemoglobin (HP:0011902)2.95379111
32Hepatocellular necrosis (HP:0001404)2.93890277
33Abnormality of macrophages (HP:0004311)2.93499430
34Mitochondrial inheritance (HP:0001427)2.91458485
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.90352036
36Reticulocytopenia (HP:0001896)2.87669540
37Polyphagia (HP:0002591)2.84278444
38Polycythemia (HP:0001901)2.84185615
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.84081076
40Macrocytic anemia (HP:0001972)2.82654224
41Severe visual impairment (HP:0001141)2.81648026
42Amyotrophic lateral sclerosis (HP:0007354)2.80593534
433-Methylglutaconic aciduria (HP:0003535)2.76692383
44Increased CSF lactate (HP:0002490)2.76129581
45Shoulder girdle muscle weakness (HP:0003547)2.75430730
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73204310
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73204310
48Cellulitis (HP:0100658)2.72787082
49Abnormality of the gallbladder (HP:0005264)2.71290378
50Progressive external ophthalmoplegia (HP:0000590)2.70576701
51Hyperthyroidism (HP:0000836)2.67030107
52Oral leukoplakia (HP:0002745)2.64437864
53Progressive macrocephaly (HP:0004481)2.63426598
54Emotional lability (HP:0000712)2.63333063
55Increased serum lactate (HP:0002151)2.58543482
56Failure to thrive in infancy (HP:0001531)2.58323999
57Birth length less than 3rd percentile (HP:0003561)2.55848829
58Lissencephaly (HP:0001339)2.54977095
59Mediastinal lymphadenopathy (HP:0100721)2.54444403
60Truncus arteriosus (HP:0001660)2.53106851
61Hypoparathyroidism (HP:0000829)2.53083079
62Unsteady gait (HP:0002317)2.51933560
63Recurrent fungal infections (HP:0002841)2.50857366
64Acute encephalopathy (HP:0006846)2.50836757
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.49981489
66Hypoplasia of the brainstem (HP:0002365)2.49981489
67Pallor (HP:0000980)2.49956562
68Myositis (HP:0100614)2.48328915
69Degeneration of anterior horn cells (HP:0002398)2.46014109
70Abnormality of the anterior horn cell (HP:0006802)2.46014109
71Seborrheic dermatitis (HP:0001051)2.45832989
72Adenoma sebaceum (HP:0009720)2.45816433
73Angiofibromas (HP:0010615)2.45816433
74Metaphyseal cupping (HP:0003021)2.45805819
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42485889
76Acute hepatic failure (HP:0006554)2.41567835
77Urticaria (HP:0001025)2.40662121
78Meningitis (HP:0001287)2.40105869
79Microvesicular hepatic steatosis (HP:0001414)2.39908437
80Personality changes (HP:0000751)2.34720876
81Encephalitis (HP:0002383)2.33785048
82Orchitis (HP:0100796)2.32984494
83Glossoptosis (HP:0000162)2.32716699
84Hypoplasia of the pons (HP:0012110)2.32461210
85Multiple enchondromatosis (HP:0005701)2.31928974
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30842996
87Abnormality of alanine metabolism (HP:0010916)2.30842996
88Hyperalaninemia (HP:0003348)2.30842996
89Recurrent skin infections (HP:0001581)2.29812121
90CNS hypomyelination (HP:0003429)2.28484314
91CNS demyelination (HP:0007305)2.27839578
92Aplasia/Hypoplasia of the thymus (HP:0010515)2.27671809
93Hepatic necrosis (HP:0002605)2.24573147
94Increased IgE level (HP:0003212)2.24111929
95Paralysis (HP:0003470)2.23756544
96Carpal bone hypoplasia (HP:0001498)2.21743572
97Cutaneous photosensitivity (HP:0000992)2.21599394
98Ragged-red muscle fibers (HP:0003200)2.21195440
99Ependymoma (HP:0002888)2.21042255
100Recurrent gram-negative bacterial infections (HP:0005420)2.20488166
101Episodic fever (HP:0001954)2.20181884
102Slow saccadic eye movements (HP:0000514)2.19843219
103Lactic acidosis (HP:0003128)2.19125516
104Hand muscle atrophy (HP:0009130)2.15517655
105Postnatal microcephaly (HP:0005484)2.15257161
106Retinal dysplasia (HP:0007973)2.13849495
107Aplasia/Hypoplasia of the earlobes (HP:0009906)2.11385606
108Horseshoe kidney (HP:0000085)2.10308280
109Chronic mucocutaneous candidiasis (HP:0002728)2.09738683
110Recurrent cutaneous fungal infections (HP:0011370)2.09738683
111Delusions (HP:0000746)2.09531552
112Diaphragmatic weakness (HP:0009113)2.09273421
113Gingivitis (HP:0000230)2.09096601
114Optic neuritis (HP:0100653)2.07829522
115Retrobulbar optic neuritis (HP:0100654)2.07829522
116Gastrointestinal inflammation (HP:0004386)2.06577793
117Pelvic girdle muscle weakness (HP:0003749)2.05888044
118Epistaxis (HP:0000421)2.05845306
119Acanthocytosis (HP:0001927)2.05771028
120Increased hepatocellular lipid droplets (HP:0006565)2.04071032
121Abnormal delayed hypersensitivity skin test (HP:0002963)2.03337325
122Hyperbilirubinemia (HP:0002904)2.02739547
123Trismus (HP:0000211)2.01560424
124Patellar aplasia (HP:0006443)2.00850054
125Mutism (HP:0002300)2.00753322
126Hepatosplenomegaly (HP:0001433)1.99012270
127Lipid accumulation in hepatocytes (HP:0006561)1.98822697
128Bowel incontinence (HP:0002607)1.98461107
129Increased IgM level (HP:0003496)1.97774682
130Insomnia (HP:0100785)1.97180875
131Peripheral hypomyelination (HP:0007182)1.95653679
132Cerebral edema (HP:0002181)1.95081518
133Abnormality of iron homeostasis (HP:0011031)1.95047138
134Aplasia/Hypoplasia of the patella (HP:0006498)1.94768135
135Fibular aplasia (HP:0002990)1.94099046
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93843530
137Toxemia of pregnancy (HP:0100603)1.93470518
138Exercise intolerance (HP:0003546)1.93402935
139Facial hemangioma (HP:0000329)1.93288878
140Respiratory failure (HP:0002878)1.93000564
141Abnormal platelet volume (HP:0011876)1.92306167
142Selective tooth agenesis (HP:0001592)1.92090180
143Abnormality of macular pigmentation (HP:0008002)1.91379615
144Aplastic anemia (HP:0001915)1.91368024
145Colon cancer (HP:0003003)1.90702684
146High anterior hairline (HP:0009890)1.90567449
147Progressive muscle weakness (HP:0003323)1.90537789
148Increased serum ferritin (HP:0003281)1.90265320
149Neoplasm of the pancreas (HP:0002894)1.89652758
150Abnormality of the pons (HP:0007361)1.89361255
151Breast hypoplasia (HP:0003187)1.89166521
152Abnormal large intestine physiology (HP:0012700)1.89067571
153Abnormality of the lower motor neuron (HP:0002366)1.87412243
154Recurrent viral infections (HP:0004429)1.86646634
155Chest pain (HP:0100749)1.86150421
156Abnormal neuron morphology (HP:0012757)1.84692747
157Abnormality of the motor neurons (HP:0002450)1.84692747
158Impaired platelet aggregation (HP:0003540)1.84084727
159Abnormal platelet function (HP:0011869)1.84084727
160Poor suck (HP:0002033)1.83868216
161Anorexia (HP:0002039)1.83829326
162Arterial thrombosis (HP:0004420)1.82212465
163Abnormality of the musculature of the pelvis (HP:0001469)1.80250889
164Abnormality of the hip-girdle musculature (HP:0001445)1.80250889
165Panhypogammaglobulinemia (HP:0003139)1.79994978
166Cerebellar hypoplasia (HP:0001321)1.79934365
167Morphological abnormality of the pyramidal tract (HP:0002062)1.79661500
168Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79392625
169Urinary urgency (HP:0000012)1.79340827
170Osteomalacia (HP:0002749)1.76906809
171Granulocytopenia (HP:0001913)1.76399568
172IgM deficiency (HP:0002850)1.76309344
173Rough bone trabeculation (HP:0100670)1.75678806
174Abnormality of the thymus (HP:0000777)1.75491379
175Visual hallucinations (HP:0002367)1.74723400
176Abnormality of the fingertips (HP:0001211)1.74070405
177Inflammation of the large intestine (HP:0002037)1.73780975
178Viral hepatitis (HP:0006562)1.72690854
179Wrist flexion contracture (HP:0001239)1.72058970
180Diminished motivation (HP:0000745)1.71984683
181Colitis (HP:0002583)1.71884941
182Abnormal number of incisors (HP:0011064)1.71540914
183Micronodular cirrhosis (HP:0001413)1.69670787
184External ophthalmoplegia (HP:0000544)1.69634386
185Cortical dysplasia (HP:0002539)1.66182889
186Abnormality of abdominal situs (HP:0011620)1.65402371
187Abdominal situs inversus (HP:0003363)1.65402371
188Abnormality of T cell physiology (HP:0011840)1.65224434
189Amniotic constriction ring (HP:0009775)1.64406890
190Basal cell carcinoma (HP:0002671)1.64108426
191Long palpebral fissure (HP:0000637)1.64002940
192Segmental peripheral demyelination/remyelination (HP:0003481)1.63425312
193Bone marrow hypocellularity (HP:0005528)1.63208526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.32382494
2BUB13.91830852
3SMG13.63877766
4WEE13.43976220
5TAOK12.88484643
6PRPF4B2.83769630
7RIPK42.81576759
8MAP2K32.79397717
9EEF2K2.78884563
10MAP4K12.63632676
11STK162.38243091
12NTRK22.38086617
13CDC72.33231195
14NME22.23111498
15IRAK42.16473829
16DYRK22.12506283
17ERN12.12077523
18TSSK62.12042239
19TNK22.09390307
20NEK12.06332812
21SCYL21.94974122
22VRK21.94663832
23KSR11.89090279
24NME11.88772884
25LIMK11.87142209
26TESK21.82912997
27EIF2AK31.81914324
28SRPK11.71279587
29CDK121.69264430
30NEK21.68741972
31EIF2AK11.58465304
32AURKA1.55120042
33PRKD31.51729342
34SIK21.49993488
35ACVR1B1.48875017
36SIK11.48020277
37FES1.46859485
38MAP3K11.46839589
39EPHA21.46198422
40RPS6KB21.45137200
41KSR21.44375321
42PNCK1.43733216
43MINK11.42098214
44TLK11.36765660
45KDR1.34256351
46MAPKAPK31.33948948
47BRSK11.33863208
48MAPK131.33793071
49MAP3K61.33252248
50PLK11.28556510
51MAP3K31.25732502
52INSRR1.21666500
53CHEK21.16710994
54DYRK31.11964278
55ICK1.10459093
56MAP2K41.10324016
57MARK21.09947301
58LATS21.07972699
59MAP3K91.07283029
60UHMK11.07128209
61BLK1.06725806
62PHKG21.06618993
63PHKG11.06618993
64MAP3K111.05877452
65EPHB11.04699703
66BTK1.01844946
67SIK31.01568975
68CSK1.01252604
69TYK21.01061624
70CAMKK21.00423623
71BRSK20.97648841
72VRK10.96558372
73RAF10.96299806
74CSNK1G30.95102830
75HCK0.94845739
76TTK0.90558453
77TNIK0.89327752
78IRAK20.89214583
79CDK70.89164171
80AURKB0.87265023
81JAK20.86819709
82PLK30.86675667
83TRIB30.86007926
84JAK30.85989267
85IRAK30.85601101
86PTK60.82396593
87MARK30.81471984
88BRAF0.81283610
89TAF10.79595067
90PKN20.79431749
91LYN0.79207238
92ILK0.78917842
93MAP3K100.78512661
94PRKD20.77360324
95CDK180.76035930
96CHEK10.75879354
97CDK40.73654129
98LRRK20.73092828
99CDK140.72760100
100PAK10.72526094
101BCKDK0.72409667
102PIM10.70382761
103CDK11A0.69214913
104CDK150.68840829
105CDK190.68320244
106CSNK1G20.68033862
107SYK0.67352529
108ATR0.66157313
109ZAP700.65812755
110TGFBR10.65801544
111PDK40.65669025
112PDK30.65669025
113PASK0.64573884
114RPS6KA40.64225457
115NTRK10.61875221
116GRK60.61639430
117DYRK1B0.61332598
118DAPK10.60734395
119PAK60.60035289
120MAP3K40.59772892
121CSNK1G10.57698233
122HIPK20.57583920
123TESK10.57043871
124BCR0.56066731
125CSNK2A20.55998340
126MATK0.55618405
127ARAF0.54970010
128CDK20.54209726
129RPS6KC10.54112031
130RPS6KL10.54112031
131PDPK10.53356457
132PLK40.53067070
133ALK0.52163519
134PIM20.51541816
135MAPK90.50802968
136YES10.50691291
137TAOK20.50195446
138RET0.49273489
139PRKCI0.48815641
140CDK80.48677043
141PDK10.48404487
142FGR0.47744858
143BMX0.47707969
144CSNK1E0.47226142
145DYRK1A0.46505828
146CCNB10.46429228
147CDK10.46392802
148BRD40.45472451
149CAMK1D0.45241121
150STK110.45014557
151MAP3K130.44997836
152IKBKE0.44700636
153CSNK2A10.43889857
154PRKCG0.43802377
155MAPK110.42920194
156MAP2K20.42691454
157TBK10.42424452
158MKNK10.41828095
159MAP3K20.41678136
160RPS6KA50.41342372
161RPS6KA10.40209403
162LCK0.40208454
163MAPKAPK50.39809374
164MAP2K70.39745761
165PRKCZ0.39204637
166CSNK1A1L0.37994514
167MAP2K10.37218506
168MAP3K80.36751732

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19985930
2Ribosome_Homo sapiens_hsa030104.09245293
3DNA replication_Homo sapiens_hsa030303.91971751
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.90923102
5RNA polymerase_Homo sapiens_hsa030203.15243291
6Mismatch repair_Homo sapiens_hsa034302.99580674
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95417458
8Parkinsons disease_Homo sapiens_hsa050122.87706763
9Spliceosome_Homo sapiens_hsa030402.86961213
10RNA transport_Homo sapiens_hsa030132.72123096
11Oxidative phosphorylation_Homo sapiens_hsa001902.70071657
12Pyrimidine metabolism_Homo sapiens_hsa002402.50940376
13Acute myeloid leukemia_Homo sapiens_hsa052212.44151377
14Nucleotide excision repair_Homo sapiens_hsa034202.36369503
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33590357
16Sulfur relay system_Homo sapiens_hsa041222.30252329
17Huntingtons disease_Homo sapiens_hsa050162.13605109
18One carbon pool by folate_Homo sapiens_hsa006702.06307685
19Base excision repair_Homo sapiens_hsa034102.04594817
20Cell cycle_Homo sapiens_hsa041102.01299067
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84810973
22B cell receptor signaling pathway_Homo sapiens_hsa046621.74557196
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71531548
24Pancreatic cancer_Homo sapiens_hsa052121.71045749
25Vitamin B6 metabolism_Homo sapiens_hsa007501.69087390
26Alzheimers disease_Homo sapiens_hsa050101.67014497
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66323861
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.65466628
29Osteoclast differentiation_Homo sapiens_hsa043801.50986956
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50824227
31Folate biosynthesis_Homo sapiens_hsa007901.40446288
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.40010903
33Homologous recombination_Homo sapiens_hsa034401.39859641
34Biosynthesis of amino acids_Homo sapiens_hsa012301.37607506
35mRNA surveillance pathway_Homo sapiens_hsa030151.36806230
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35673673
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31304777
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30128127
39Hepatitis B_Homo sapiens_hsa051611.29208909
40Notch signaling pathway_Homo sapiens_hsa043301.28481914
41Cardiac muscle contraction_Homo sapiens_hsa042601.28221241
42VEGF signaling pathway_Homo sapiens_hsa043701.20408846
43Leishmaniasis_Homo sapiens_hsa051401.20348286
44Primary immunodeficiency_Homo sapiens_hsa053401.19630791
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19360272
46Purine metabolism_Homo sapiens_hsa002301.17409765
47Pentose phosphate pathway_Homo sapiens_hsa000301.15644498
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.15637512
49mTOR signaling pathway_Homo sapiens_hsa041501.14477439
50Carbon metabolism_Homo sapiens_hsa012001.14433333
51Measles_Homo sapiens_hsa051621.12945535
52RNA degradation_Homo sapiens_hsa030181.12034579
53Oocyte meiosis_Homo sapiens_hsa041141.08279218
54Alcoholism_Homo sapiens_hsa050341.08036871
55Apoptosis_Homo sapiens_hsa042101.07221568
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06992566
57Systemic lupus erythematosus_Homo sapiens_hsa053221.06711133
58Tuberculosis_Homo sapiens_hsa051521.06038543
59Herpes simplex infection_Homo sapiens_hsa051681.03571383
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03002157
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00265685
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97007203
63T cell receptor signaling pathway_Homo sapiens_hsa046600.96930383
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95501023
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93315435
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.92851195
67HIF-1 signaling pathway_Homo sapiens_hsa040660.91551059
68Malaria_Homo sapiens_hsa051440.91452210
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90910971
70Chemokine signaling pathway_Homo sapiens_hsa040620.90186943
71N-Glycan biosynthesis_Homo sapiens_hsa005100.89886396
72Basal transcription factors_Homo sapiens_hsa030220.89268601
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88432275
74Synaptic vesicle cycle_Homo sapiens_hsa047210.87907956
75Fanconi anemia pathway_Homo sapiens_hsa034600.87694098
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85580802
77Nicotine addiction_Homo sapiens_hsa050330.84989275
78Pyruvate metabolism_Homo sapiens_hsa006200.84714270
79Epstein-Barr virus infection_Homo sapiens_hsa051690.83870631
80Shigellosis_Homo sapiens_hsa051310.82881838
81Butanoate metabolism_Homo sapiens_hsa006500.82606186
82Inositol phosphate metabolism_Homo sapiens_hsa005620.81712315
83Hepatitis C_Homo sapiens_hsa051600.78751841
84Endocytosis_Homo sapiens_hsa041440.78167513
85Bladder cancer_Homo sapiens_hsa052190.77796740
86Type II diabetes mellitus_Homo sapiens_hsa049300.77691082
87Insulin signaling pathway_Homo sapiens_hsa049100.77503595
88Prolactin signaling pathway_Homo sapiens_hsa049170.74021187
89AMPK signaling pathway_Homo sapiens_hsa041520.73171955
90p53 signaling pathway_Homo sapiens_hsa041150.72322073
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71942798
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71591596
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70884035
94Fructose and mannose metabolism_Homo sapiens_hsa000510.70505422
95Thyroid cancer_Homo sapiens_hsa052160.69955220
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.68679979
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.68624636
98Choline metabolism in cancer_Homo sapiens_hsa052310.68504123
99Influenza A_Homo sapiens_hsa051640.68275866
100Protein export_Homo sapiens_hsa030600.67095525
101ErbB signaling pathway_Homo sapiens_hsa040120.67066919
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67026310
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63655830
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61401951
105Metabolic pathways_Homo sapiens_hsa011000.60487020
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60036267
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.60030641
108Legionellosis_Homo sapiens_hsa051340.59647220
109Colorectal cancer_Homo sapiens_hsa052100.59165278
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.58335156
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.57565959
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.57101295
113Fatty acid biosynthesis_Homo sapiens_hsa000610.57000541
114Prostate cancer_Homo sapiens_hsa052150.56992258
115African trypanosomiasis_Homo sapiens_hsa051430.56849335
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56417727
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56167130
118Other glycan degradation_Homo sapiens_hsa005110.56038409
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55139148
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54740160
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53023412
122Viral carcinogenesis_Homo sapiens_hsa052030.51451054
123FoxO signaling pathway_Homo sapiens_hsa040680.51179667
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49234080
125Hematopoietic cell lineage_Homo sapiens_hsa046400.48090908
126Non-homologous end-joining_Homo sapiens_hsa034500.47302352
127Collecting duct acid secretion_Homo sapiens_hsa049660.46955983
128Platelet activation_Homo sapiens_hsa046110.46514093
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43485553
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43460500
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41854489
132Gap junction_Homo sapiens_hsa045400.40802303
133Glutathione metabolism_Homo sapiens_hsa004800.40618981
134Olfactory transduction_Homo sapiens_hsa047400.36926222
135Steroid biosynthesis_Homo sapiens_hsa001000.34893019
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32444386
137Non-small cell lung cancer_Homo sapiens_hsa052230.31800525
138Hippo signaling pathway_Homo sapiens_hsa043900.30259171
139Endometrial cancer_Homo sapiens_hsa052130.29902472
140Vibrio cholerae infection_Homo sapiens_hsa051100.28874083
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28709508
142Basal cell carcinoma_Homo sapiens_hsa052170.26344164
143Renal cell carcinoma_Homo sapiens_hsa052110.25511694
144Arginine and proline metabolism_Homo sapiens_hsa003300.25246772
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23821053
146Regulation of autophagy_Homo sapiens_hsa041400.23521096
147Galactose metabolism_Homo sapiens_hsa000520.23488792
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22294847
149HTLV-I infection_Homo sapiens_hsa051660.21343109
150GABAergic synapse_Homo sapiens_hsa047270.17753369
151Fatty acid metabolism_Homo sapiens_hsa012120.16589625
152Glioma_Homo sapiens_hsa052140.15502816
153Chronic myeloid leukemia_Homo sapiens_hsa052200.15474102
154Dopaminergic synapse_Homo sapiens_hsa047280.11045537
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10398066
156Hedgehog signaling pathway_Homo sapiens_hsa043400.09326443
157Phenylalanine metabolism_Homo sapiens_hsa003600.08898495
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08785965
159Selenocompound metabolism_Homo sapiens_hsa004500.05745952
160Axon guidance_Homo sapiens_hsa043600.05514443

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