DHRS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)8.56772752
2plasma lipoprotein particle assembly (GO:0034377)7.80001484
3negative regulation of fibrinolysis (GO:0051918)7.69811158
4piRNA metabolic process (GO:0034587)7.11628031
5low-density lipoprotein particle remodeling (GO:0034374)6.86608856
6protein-lipid complex assembly (GO:0065005)6.85296846
7mitotic metaphase plate congression (GO:0007080)6.83542010
8regulation of fibrinolysis (GO:0051917)6.61710640
9regulation of female gonad development (GO:2000194)6.60400632
10intestinal cholesterol absorption (GO:0030299)6.52599498
11peptidyl-glutamic acid carboxylation (GO:0017187)6.42504348
12protein carboxylation (GO:0018214)6.42504348
13regulation of protein activation cascade (GO:2000257)5.94811546
14metaphase plate congression (GO:0051310)5.94266794
15regulation of apoptotic cell clearance (GO:2000425)5.86196505
16regulation of complement activation (GO:0030449)5.85874636
17cholesterol efflux (GO:0033344)5.83547949
18attachment of spindle microtubules to kinetochore (GO:0008608)5.68806694
19plasma lipoprotein particle remodeling (GO:0034369)5.68557799
20protein-lipid complex remodeling (GO:0034368)5.68557799
21macromolecular complex remodeling (GO:0034367)5.68557799
22regulation of meiosis (GO:0040020)5.65938957
23regulation of cholesterol esterification (GO:0010872)5.60087037
24negative regulation of meiosis (GO:0045835)5.59608835
25plasma lipoprotein particle organization (GO:0071827)5.59541725
26mitotic chromosome condensation (GO:0007076)5.58723924
27meiotic cell cycle (GO:0051321)5.49073439
28establishment of chromosome localization (GO:0051303)5.39487459
29protein-lipid complex subunit organization (GO:0071825)5.21245847
30blood coagulation, intrinsic pathway (GO:0007597)5.13877474
31regulation of histone H3-K27 methylation (GO:0061085)5.03129084
32regulation of exit from mitosis (GO:0007096)5.02281986
33maturation of 5.8S rRNA (GO:0000460)4.99173704
34meiotic chromosome segregation (GO:0045132)4.98241371
35L-phenylalanine metabolic process (GO:0006558)4.97297550
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.97297550
37high-density lipoprotein particle remodeling (GO:0034375)4.94434509
38plasma lipoprotein particle clearance (GO:0034381)4.91253628
39regulation of cholesterol biosynthetic process (GO:0045540)4.83380791
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80071977
41L-phenylalanine catabolic process (GO:0006559)4.80071977
42kinetochore assembly (GO:0051382)4.79873278
43CENP-A containing nucleosome assembly (GO:0034080)4.73551465
44regulation of cholesterol homeostasis (GO:2000188)4.70095178
45protein K6-linked ubiquitination (GO:0085020)4.68504309
46female gamete generation (GO:0007292)4.65682977
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.65021400
48male meiosis (GO:0007140)4.58888517
49kinetochore organization (GO:0051383)4.57668164
50reverse cholesterol transport (GO:0043691)4.55837171
51regulation of plasminogen activation (GO:0010755)4.55729415
52intestinal absorption (GO:0050892)4.55206861
53low-density lipoprotein particle clearance (GO:0034383)4.41193044
54DNA methylation involved in gamete generation (GO:0043046)4.41157640
55chromatin remodeling at centromere (GO:0031055)4.40918880
56regulation of bile acid biosynthetic process (GO:0070857)4.37982501
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35048740
58regulation of meiotic cell cycle (GO:0051445)4.34256729
59proline metabolic process (GO:0006560)4.32112086
60mitotic sister chromatid segregation (GO:0000070)4.24206206
61negative regulation of smooth muscle cell differentiation (GO:0051151)4.20547345
62proline biosynthetic process (GO:0006561)4.17360745
63negative regulation of protein activation cascade (GO:2000258)4.17030602
64DNA replication-independent nucleosome assembly (GO:0006336)4.11018078
65DNA replication-independent nucleosome organization (GO:0034724)4.11018078
66regulation of spindle organization (GO:0090224)4.10642179
67positive regulation of extracellular matrix organization (GO:1903055)4.08644832
68DNA damage induced protein phosphorylation (GO:0006975)4.08486826
69histone H2A monoubiquitination (GO:0035518)4.08179913
70oocyte maturation (GO:0001556)4.05947862
71diacylglycerol metabolic process (GO:0046339)4.04975342
72negative regulation of sterol transport (GO:0032372)4.03937391
73negative regulation of cholesterol transport (GO:0032375)4.03937391
74protein localization to kinetochore (GO:0034501)3.97077071
75protein localization to chromosome, centromeric region (GO:0071459)3.96774042
76regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.96496650
77lung epithelium development (GO:0060428)3.95322918
78spindle checkpoint (GO:0031577)3.90951920
79multicellular organism reproduction (GO:0032504)3.88324522
80histone exchange (GO:0043486)3.87595204
81chromosome segregation (GO:0007059)3.86015017
82lipoprotein metabolic process (GO:0042157)3.85725848
83negative regulation of homotypic cell-cell adhesion (GO:0034111)3.80537806
84melanin biosynthetic process (GO:0042438)3.80422979
85negative regulation of histone methylation (GO:0031061)3.79181506
86regulation of meiosis I (GO:0060631)3.77775337
87negative regulation of meiotic cell cycle (GO:0051447)3.76456918
88cellular response to gamma radiation (GO:0071480)3.75799544
89negative regulation of keratinocyte proliferation (GO:0010839)3.68426132
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.65377593
91notochord development (GO:0030903)3.61288718
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60215203
93regulation of sister chromatid cohesion (GO:0007063)3.58096150
94cholesterol transport (GO:0030301)3.57262645
95sterol transport (GO:0015918)3.57262645
96positive regulation of steroid metabolic process (GO:0045940)3.57221351
97negative regulation of sodium ion transport (GO:0010766)3.56211566
98positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54826336
99glutamate metabolic process (GO:0006536)3.53500859
100embryonic retina morphogenesis in camera-type eye (GO:0060059)3.51647061
101sister chromatid segregation (GO:0000819)3.50470897
102cholesterol homeostasis (GO:0042632)3.49993511
103negative regulation of nuclear division (GO:0051784)3.49962939
104positive regulation of dendritic spine morphogenesis (GO:0061003)3.49796364
105sterol homeostasis (GO:0055092)3.48270455
106regulation of cholesterol metabolic process (GO:0090181)3.46712260
107regulation of chromosome segregation (GO:0051983)3.45557587
108mitotic spindle checkpoint (GO:0071174)3.44738430
109microtubule severing (GO:0051013)3.44557197
110pinocytosis (GO:0006907)3.42846694
111protein localization to chromosome (GO:0034502)3.42485050
112female gonad development (GO:0008585)3.41016685
113phospholipid efflux (GO:0033700)3.40450974
114positive regulation of DNA-dependent DNA replication (GO:2000105)3.40276706
115histone H2A ubiquitination (GO:0033522)3.40156112
116complement activation, alternative pathway (GO:0006957)3.40009904
117negative regulation of cell division (GO:0051782)3.39951849
118positive regulation of hormone metabolic process (GO:0032352)3.38201192
119DNA damage response, signal transduction resulting in transcription (GO:0042772)3.37440220
120regulation of extracellular matrix organization (GO:1903053)3.36155438
121cellular zinc ion homeostasis (GO:0006882)3.35577793
122negative regulation of complement activation (GO:0045916)3.34357184
123melanin metabolic process (GO:0006582)3.32541461
124negative regulation of mitotic sister chromatid separation (GO:2000816)3.32175840
125negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32175840
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32175840
127negative regulation of sister chromatid segregation (GO:0033046)3.32175840
128acute-phase response (GO:0006953)3.31804733
129COPII vesicle coating (GO:0048208)3.31108756
130modified amino acid transport (GO:0072337)3.30904994
131mitotic spindle assembly checkpoint (GO:0007094)3.30313432
132protein polyglutamylation (GO:0018095)3.29890799
133positive regulation of hormone biosynthetic process (GO:0046886)3.29625069
134negative regulation of chromosome segregation (GO:0051985)3.29296264
135positive regulation of blood coagulation (GO:0030194)3.28881068
136positive regulation of hemostasis (GO:1900048)3.28881068
137monoubiquitinated protein deubiquitination (GO:0035520)3.28834476
138trivalent inorganic anion homeostasis (GO:0072506)3.28647347
139phosphate ion homeostasis (GO:0055062)3.28647347
140DNA replication checkpoint (GO:0000076)3.28615079
141negative regulation of hormone metabolic process (GO:0032351)3.26757835
142negative regulation of hormone biosynthetic process (GO:0032353)3.26757835
143regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26523019
144regulation of DNA methylation (GO:0044030)3.25805807
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25213288
146positive regulation of triglyceride lipase activity (GO:0061365)3.24945076
147positive regulation of lipoprotein lipase activity (GO:0051006)3.24945076
148positive regulation of megakaryocyte differentiation (GO:0045654)3.23929081
149positive regulation of fatty acid biosynthetic process (GO:0045723)3.21826561
150dicarboxylic acid biosynthetic process (GO:0043650)3.21472797
151ventricular cardiac muscle cell development (GO:0055015)3.20588693
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20572702
153regulation of mitotic spindle checkpoint (GO:1903504)3.20572702
154regulation of acrosome reaction (GO:0060046)3.20022487
155vitamin transmembrane transport (GO:0035461)3.19873067
156DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.19101299
157positive regulation of T cell apoptotic process (GO:0070234)3.18690886
158protein K11-linked ubiquitination (GO:0070979)3.18227265
159spindle assembly checkpoint (GO:0071173)3.18000722
160regulation of mitotic spindle organization (GO:0060236)3.17656473
161microtubule nucleation (GO:0007020)3.17216653
162protein complex localization (GO:0031503)3.16607886
163protein deneddylation (GO:0000338)3.15629104
164negative regulation of reproductive process (GO:2000242)3.15033459
165base-excision repair, AP site formation (GO:0006285)3.15022885
166response to prostaglandin (GO:0034694)3.13401381
167nephron epithelium morphogenesis (GO:0072088)3.13180524
168nephron tubule morphogenesis (GO:0072078)3.13180524
169response to vitamin A (GO:0033189)3.11162623
170mitotic G2/M transition checkpoint (GO:0044818)3.10711620
171negative regulation of hemostasis (GO:1900047)3.10118689
172negative regulation of blood coagulation (GO:0030195)3.10118689
173chromatin assembly or disassembly (GO:0006333)3.09988405
174regulation of humoral immune response (GO:0002920)3.09288976
175mitotic nuclear envelope disassembly (GO:0007077)3.07808582
176chaperone-mediated protein transport (GO:0072321)3.07121369
177fibrinolysis (GO:0042730)3.06098770
178negative regulation of mitosis (GO:0045839)3.04881572
179citrulline biosynthetic process (GO:0019240)3.04341493
180cytoskeleton-dependent cytokinesis (GO:0061640)3.04196029
181meiotic nuclear division (GO:0007126)3.03638745
182positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.03505470
183pyrimidine nucleotide catabolic process (GO:0006244)3.03191657
184gene silencing by RNA (GO:0031047)3.02872761
185cell proliferation involved in metanephros development (GO:0072203)2.99912714
186positive regulation of coagulation (GO:0050820)2.98548183
187lipid homeostasis (GO:0055088)2.95863145
188renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.94739367
1894-hydroxyproline metabolic process (GO:0019471)2.93686367
190artery smooth muscle contraction (GO:0014824)2.93142281
191negative regulation of lipase activity (GO:0060192)2.91941994
192protein activation cascade (GO:0072376)2.87663460
193regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87004616
194negative regulation of coagulation (GO:0050819)2.86673803
195neutral lipid catabolic process (GO:0046461)2.85049910
196acylglycerol catabolic process (GO:0046464)2.85049910
197regulation of norepinephrine secretion (GO:0014061)2.82760213
198regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.82250530
199neurotransmitter-gated ion channel clustering (GO:0072578)2.82079518
200ERK1 and ERK2 cascade (GO:0070371)2.79379128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.33394339
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.06948332
3EZH2_22144423_ChIP-Seq_EOC_Human4.26280176
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.95159672
5* FOXA2_19822575_ChIP-Seq_HepG2_Human3.86750811
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.79181963
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.78234098
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.58081036
9E2F7_22180533_ChIP-Seq_HELA_Human3.44321553
10AR_21909140_ChIP-Seq_LNCAP_Human3.35687238
11RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14235527
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.11038017
13LXR_22158963_ChIP-Seq_LIVER_Mouse3.08681720
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07740856
15* ZNF263_19887448_ChIP-Seq_K562_Human2.98870951
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.92843845
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.88931369
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.87216674
19* HNF4A_19822575_ChIP-Seq_HepG2_Human2.80234057
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.74420551
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.72071328
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68752398
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.65361240
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.59835736
25CLOCK_20551151_ChIP-Seq_293T_Human2.56318131
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.52849513
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49675440
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.42244347
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41769132
30* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.36325596
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15306488
32SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.02018034
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95698007
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95186732
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95049927
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92754162
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.92520252
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88358765
39FUS_26573619_Chip-Seq_HEK293_Human1.83235783
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83229529
41EWS_26573619_Chip-Seq_HEK293_Human1.80263470
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79886520
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.79849165
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.78674568
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74942089
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74119210
47IGF1R_20145208_ChIP-Seq_DFB_Human1.72500781
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72033938
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.70366375
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67283111
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66304342
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65305723
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65068376
54MYC_18940864_ChIP-ChIP_HL60_Human1.64087043
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64073183
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63437304
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.62920792
58GATA6_25053715_ChIP-Seq_YYC3_Human1.62744622
59GATA4_25053715_ChIP-Seq_YYC3_Human1.62615835
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.61236399
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60260259
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59558742
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57806196
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.57426893
65* ESR2_21235772_ChIP-Seq_MCF-7_Human1.56635089
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.56000597
67RNF2_27304074_Chip-Seq_NSC_Mouse1.55225396
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.55190005
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52653823
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52420889
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.52036262
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51556315
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.51420928
74GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.49847626
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.48294031
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48264361
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47841648
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44768138
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44768138
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.44564108
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42077701
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39442135
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38554058
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38262474
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36729326
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36490934
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34010813
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33902700
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33750664
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.33049728
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32008256
92HTT_18923047_ChIP-ChIP_STHdh_Human1.30241953
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.29613250
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29390420
95STAT1_17558387_ChIP-Seq_HELA_Human1.29056315
96* STAT3_23295773_ChIP-Seq_U87_Human1.28532657
97RACK7_27058665_Chip-Seq_MCF-7_Human1.27011043
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26846478
99* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24913254
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24297868
101* ESR1_21235772_ChIP-Seq_MCF-7_Human1.22290660
102* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21884892
103AR_21572438_ChIP-Seq_LNCaP_Human1.21250459
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21111960
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19235710
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19230552
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18370641
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.18369257
109GF1B_26923725_Chip-Seq_HPCs_Mouse1.17970396
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17651470
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17488039
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16879144
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16206221
114ATF3_27146783_Chip-Seq_COLON_Human1.15903938
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.15823261
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.14524772
117MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14409615
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.14202277
119LXR_22292898_ChIP-Seq_THP-1_Human1.12576035
120MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11958983
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.11934861
122P300_19829295_ChIP-Seq_ESCs_Human1.11908756
123NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11343774
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.10934215
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09388105
126SOX17_20123909_ChIP-Seq_XEN_Mouse1.08455152
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08330156
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.07853373
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07505975
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.06633354
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.06490425
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.05866335
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.04774355
134P53_22387025_ChIP-Seq_ESCs_Mouse1.04688005
135CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04579502
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04469482
137* SMAD4_21799915_ChIP-Seq_A2780_Human1.03968873
138TP53_22127205_ChIP-Seq_IMR90_Human1.02825269
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02719146
140MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02474562
141JUN_21703547_ChIP-Seq_K562_Human1.02276371
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01187917
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00842830
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00457235
145RARA_24833708_ChIP-Seq_LIVER_Mouse1.00081437
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99166624
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98583815
148VDR_22108803_ChIP-Seq_LS180_Human0.98457056
149ZFX_18555785_Chip-Seq_ESCs_Mouse0.97726835
150POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97131386
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.96512754
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96096269
153KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95997753
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95736624
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95698407
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95609075
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95129588
158TBL1_22424771_ChIP-Seq_293T_Human0.94915586
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94478335
160NFYA_21822215_ChIP-Seq_K562_Human0.94003237
161* GABP_19822575_ChIP-Seq_HepG2_Human0.94000980
162* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93596754
163MYC_22102868_ChIP-Seq_BL_Human0.93324122
164GATA3_24758297_ChIP-Seq_MCF-7_Human0.92558368
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92060387
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92059784
167PHF8_20622853_ChIP-Seq_HELA_Human0.91680531
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91259280
169P300_18555785_Chip-Seq_ESCs_Mouse0.90792028
170NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90093192
171CDX2_22108803_ChIP-Seq_LS180_Human0.89861475
172WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89832259
173TCF4_23295773_ChIP-Seq_U87_Human0.89585888
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89194333
175CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88682514
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88645950
177PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88607567
178EP300_21415370_ChIP-Seq_HL-1_Mouse0.88538072
179* KDM2B_26808549_Chip-Seq_REH_Human0.88360186
180CJUN_26792858_Chip-Seq_BT549_Human0.88165209
181NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87761512
182KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87674301
183RARB_24833708_ChIP-Seq_LIVER_Mouse0.87408477
184* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85640370
185STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82190610
186PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80350227
187ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79878021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.69089962
2MP0005451_abnormal_body_composition4.68827619
3MP0002139_abnormal_hepatobiliary_system4.44975839
4MP0003718_maternal_effect4.40921968
5MP0005360_urolithiasis4.15434218
6MP0003136_yellow_coat_color3.97929787
7MP0005365_abnormal_bile_salt3.95062856
8MP0003195_calcinosis3.77187854
9MP0008877_abnormal_DNA_methylation3.56661100
10MP0001666_abnormal_nutrient_absorption3.55767171
11MP0010094_abnormal_chromosome_stability3.36717639
12MP0010329_abnormal_lipoprotein_level3.23877441
13MP0000372_irregular_coat_pigmentation3.14277167
14MP0002102_abnormal_ear_morphology3.08304612
15MP0003693_abnormal_embryo_hatching2.98321007
16MP0004381_abnormal_hair_follicle2.75180094
17MP0008875_abnormal_xenobiotic_pharmacok2.74920941
18MP0005408_hypopigmentation2.73128042
19MP0003077_abnormal_cell_cycle2.60546506
20MP0002089_abnormal_postnatal_growth/wei2.58406830
21MP0006292_abnormal_olfactory_placode2.49041273
22MP0005085_abnormal_gallbladder_physiolo2.48641920
23MP0003172_abnormal_lysosome_physiology2.40604321
24MP0003111_abnormal_nucleus_morphology2.40542951
25MP0005058_abnormal_lysosome_morphology2.37516769
26MP0004264_abnormal_extraembryonic_tissu2.33868376
27MP0009780_abnormal_chondrocyte_physiolo2.33827908
28MP0003123_paternal_imprinting2.32557553
29MP0002163_abnormal_gland_morphology2.20289437
30MP0001119_abnormal_female_reproductive2.18365364
31MP0005171_absent_coat_pigmentation2.16881395
32MP0003315_abnormal_perineum_morphology2.15538450
33MP0005257_abnormal_intraocular_pressure2.03917977
34MP0003699_abnormal_female_reproductive2.02730386
35MP0009697_abnormal_copulation1.99548841
36MP0001915_intracranial_hemorrhage1.98070024
37MP0003868_abnormal_feces_composition1.96611059
38MP0000537_abnormal_urethra_morphology1.95922165
39MP0010386_abnormal_urinary_bladder1.94925480
40MP0005395_other_phenotype1.94278793
41MP0003121_genomic_imprinting1.93743457
42MP0004957_abnormal_blastocyst_morpholog1.92450293
43MP0002653_abnormal_ependyma_morphology1.90876687
44MP0005409_darkened_coat_color1.90233674
45MP0003252_abnormal_bile_duct1.83156659
46MP0002736_abnormal_nociception_after1.82058994
47MP0002735_abnormal_chemical_nociception1.75246064
48MP0001929_abnormal_gametogenesis1.69492444
49MP0003787_abnormal_imprinting1.68451295
50MP0008932_abnormal_embryonic_tissue1.66140667
51MP0000653_abnormal_sex_gland1.65568713
52MP0002210_abnormal_sex_determination1.64320409
53MP0000609_abnormal_liver_physiology1.61677067
54MP0006054_spinal_hemorrhage1.60862683
55MP0003950_abnormal_plasma_membrane1.60084283
56MP0003937_abnormal_limbs/digits/tail_de1.58637159
57MP0005076_abnormal_cell_differentiation1.55753692
58MP0000427_abnormal_hair_cycle1.48956368
59MP0000579_abnormal_nail_morphology1.45665350
60MP0008057_abnormal_DNA_replication1.45135712
61MP0001270_distended_abdomen1.38319781
62MP0002118_abnormal_lipid_homeostasis1.37688171
63MP0009384_cardiac_valve_regurgitation1.32951242
64MP0008007_abnormal_cellular_replicative1.30652495
65MP0005332_abnormal_amino_acid1.28312544
66MP0009840_abnormal_foam_cell1.24731855
67MP0001529_abnormal_vocalization1.23212604
68MP0004272_abnormal_basement_membrane1.20334665
69MP0001968_abnormal_touch/_nociception1.17437304
70MP0005187_abnormal_penis_morphology1.16839529
71MP0002734_abnormal_mechanical_nocicepti1.15836251
72MP0000639_abnormal_adrenal_gland1.15044637
73MP0002249_abnormal_larynx_morphology1.14615771
74MP0001145_abnormal_male_reproductive1.11986721
75MP0001661_extended_life_span1.11353689
76MP0004782_abnormal_surfactant_physiolog1.09708442
77MP0003115_abnormal_respiratory_system1.09586788
78MP0003941_abnormal_skin_development1.08575374
79MP0002909_abnormal_adrenal_gland1.08494044
80MP0008260_abnormal_autophagy1.07894775
81MP0003566_abnormal_cell_adhesion1.07634862
82MP0000598_abnormal_liver_morphology1.04472742
83MP0000383_abnormal_hair_follicle1.02958871
84MP0003656_abnormal_erythrocyte_physiolo1.02940397
85MP0002161_abnormal_fertility/fecundity1.00794646
86MP0003183_abnormal_peptide_metabolism1.00332280
87MP0005379_endocrine/exocrine_gland_phen0.98801529
88MP0002938_white_spotting0.98264786
89MP0001919_abnormal_reproductive_system0.96695417
90MP0005636_abnormal_mineral_homeostasis0.96556453
91MP0003453_abnormal_keratinocyte_physiol0.93047738
92MP0002095_abnormal_skin_pigmentation0.92774221
93MP0001697_abnormal_embryo_size0.92545041
94MP0002085_abnormal_embryonic_tissue0.92491449
95MP0003567_abnormal_fetal_cardiomyocyte0.92246408
96MP0004185_abnormal_adipocyte_glucose0.90536425
97MP0004484_altered_response_of0.90143457
98MP0005646_abnormal_pituitary_gland0.87433018
99MP0002086_abnormal_extraembryonic_tissu0.86913110
100MP0005410_abnormal_fertilization0.85848210
101MP0002132_abnormal_respiratory_system0.85448600
102MP0008058_abnormal_DNA_repair0.84310919
103MP0000003_abnormal_adipose_tissue0.83776962
104MP0005220_abnormal_exocrine_pancreas0.83490163
105MP0005167_abnormal_blood-brain_barrier0.83204954
106MP0001730_embryonic_growth_arrest0.82751765
107MP0005248_abnormal_Harderian_gland0.81929338
108MP0004019_abnormal_vitamin_homeostasis0.81300874
109MP0002160_abnormal_reproductive_system0.81148436
110MP0010368_abnormal_lymphatic_system0.80622260
111MP0000350_abnormal_cell_proliferation0.79579746
112MP0001672_abnormal_embryogenesis/_devel0.77452751
113MP0005380_embryogenesis_phenotype0.77452751
114MP0001756_abnormal_urination0.76661991
115MP0000534_abnormal_ureter_morphology0.75932959
116MP0002084_abnormal_developmental_patter0.75826373
117MP0000858_altered_metastatic_potential0.75251326
118MP0005075_abnormal_melanosome_morpholog0.74766689
119MP0000538_abnormal_urinary_bladder0.74502106
120MP0002184_abnormal_innervation0.74065880
121MP0003984_embryonic_growth_retardation0.72778880
122MP0005084_abnormal_gallbladder_morpholo0.72271319
123MP0004270_analgesia0.71766151
124MP0003878_abnormal_ear_physiology0.71630600
125MP0005377_hearing/vestibular/ear_phenot0.71630600
126MP0009642_abnormal_blood_homeostasis0.71141501
127MP0002088_abnormal_embryonic_growth/wei0.70958784
128MP0010678_abnormal_skin_adnexa0.70801729
129MP0003755_abnormal_palate_morphology0.70243597
130MP0000678_abnormal_parathyroid_gland0.69729977
131MP0003122_maternal_imprinting0.69364965
132MP0003698_abnormal_male_reproductive0.69145490
133MP0010630_abnormal_cardiac_muscle0.69037818
134MP0002092_abnormal_eye_morphology0.68904601
135MP0005389_reproductive_system_phenotype0.68844155
136MP0004036_abnormal_muscle_relaxation0.68077103
137MP0005330_cardiomyopathy0.67947286
138MP0001970_abnormal_pain_threshold0.66634947
139MP0003943_abnormal_hepatobiliary_system0.65421053
140MP0001286_abnormal_eye_development0.65192793
141MP0003632_abnormal_nervous_system0.65119208
142MP0005464_abnormal_platelet_physiology0.63966867
143MP0005319_abnormal_enzyme/_coenzyme0.63805899
144MP0009115_abnormal_fat_cell0.63666821
145MP0000920_abnormal_myelination0.63428280
146MP0009672_abnormal_birth_weight0.62815054
147MP0009643_abnormal_urine_homeostasis0.61811138
148MP0009250_abnormal_appendicular_skeleto0.61747000
149MP0003890_abnormal_embryonic-extraembry0.61634192
150MP0002697_abnormal_eye_size0.61464950
151MP0000371_diluted_coat_color0.61260966
152MP0000751_myopathy0.60566909
153MP0002080_prenatal_lethality0.60529181
154MP0003942_abnormal_urinary_system0.59194638
155MP0000490_abnormal_crypts_of0.59152462
156MP0003221_abnormal_cardiomyocyte_apopto0.59088450
157MP0003953_abnormal_hormone_level0.59079793
158MP0010234_abnormal_vibrissa_follicle0.58952697
159MP0002078_abnormal_glucose_homeostasis0.58086704
160MP0002075_abnormal_coat/hair_pigmentati0.57611763
161MP0001324_abnormal_eye_pigmentation0.57349118
162MP0001764_abnormal_homeostasis0.56822072
163MP0002282_abnormal_trachea_morphology0.55940350
164MP0002972_abnormal_cardiac_muscle0.55666569
165MP0002971_abnormal_brown_adipose0.54830958
166MP0002933_joint_inflammation0.54317945
167MP0002127_abnormal_cardiovascular_syste0.54028745
168MP0003861_abnormal_nervous_system0.53629004
169MP0002638_abnormal_pupillary_reflex0.53306987
170MP0004510_myositis0.53268372
171MP0000566_synostosis0.53090317
172MP0000026_abnormal_inner_ear0.52687312
173MP0002109_abnormal_limb_morphology0.52245469
174MP0004233_abnormal_muscle_weight0.52085167

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.86547888
2Male infertility (HP:0003251)6.61433533
3Hypobetalipoproteinemia (HP:0003563)5.69026427
4Chromsome breakage (HP:0040012)5.46186883
5Joint hemorrhage (HP:0005261)5.17366107
6Abnormality of the common coagulation pathway (HP:0010990)5.06272706
7Small epiphyses (HP:0010585)4.97817596
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55044734
9Complement deficiency (HP:0004431)4.37953351
10Hypercholesterolemia (HP:0003124)4.22379067
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12833203
12Acanthocytosis (HP:0001927)4.02754217
13Abnormality of carpal bone ossification (HP:0006257)3.91028653
14Glomerulonephritis (HP:0000099)3.89854540
15Breast hypoplasia (HP:0003187)3.87587857
16Xanthomatosis (HP:0000991)3.79880307
17Hemorrhage of the eye (HP:0011885)3.73415319
18Broad alveolar ridges (HP:0000187)3.70783220
19Abnormal tarsal ossification (HP:0008369)3.67824236
20Asymmetry of the thorax (HP:0001555)3.66293133
21Meckel diverticulum (HP:0002245)3.63027362
22Papillary thyroid carcinoma (HP:0002895)3.62658853
23Hypoplasia of the fovea (HP:0007750)3.58451748
24Aplasia/Hypoplasia of the fovea (HP:0008060)3.58451748
25Flat acetabular roof (HP:0003180)3.57807769
26Menorrhagia (HP:0000132)3.56743382
27Hypolipoproteinemia (HP:0010981)3.56031510
28Shawl scrotum (HP:0000049)3.55471783
29Irregular epiphyses (HP:0010582)3.49728033
30Abnormality of the preputium (HP:0100587)3.46098187
31Flat capital femoral epiphysis (HP:0003370)3.40450971
32Birth length less than 3rd percentile (HP:0003561)3.36243181
33Adrenal hypoplasia (HP:0000835)3.33862983
34Pancreatic islet-cell hyperplasia (HP:0004510)3.32331155
35Abnormality of the ileum (HP:0001549)3.30704803
36Abnormality of the fovea (HP:0000493)3.29251618
37Breast aplasia (HP:0100783)3.29046292
38Infertility (HP:0000789)3.28137090
39Small intestinal stenosis (HP:0012848)3.26882073
40Duodenal stenosis (HP:0100867)3.26882073
41Aplasia/Hypoplasia of the breasts (HP:0010311)3.26746604
42Aplasia/Hypoplasia of the uvula (HP:0010293)3.25861607
43Abnormality of complement system (HP:0005339)3.19409869
44Abnormality of chromosome stability (HP:0003220)3.15840460
45Spontaneous abortion (HP:0005268)3.12824600
46Cortical dysplasia (HP:0002539)3.11203186
47Ulnar claw (HP:0001178)3.02929541
48Patellar aplasia (HP:0006443)3.01605294
49Aplasia/Hypoplasia of the macula (HP:0008059)2.98845194
50Epiphyseal dysplasia (HP:0002656)2.98538474
51Epidermoid cyst (HP:0200040)2.95722442
52Abnormal ossification of hand bones (HP:0005921)2.95710483
53Vascular calcification (HP:0004934)2.94125196
54Hypergonadotropic hypogonadism (HP:0000815)2.93231807
55Ectopic kidney (HP:0000086)2.91790280
56Abnormal hand bone ossification (HP:0010660)2.89615111
57Abnormality of glycolysis (HP:0004366)2.76483402
58Vaginal fistula (HP:0004320)2.70866433
59Increased serum pyruvate (HP:0003542)2.70738896
60Aplasia/Hypoplasia of the patella (HP:0006498)2.67972189
61Abnormality of the labia minora (HP:0012880)2.67266277
62Fetal akinesia sequence (HP:0001989)2.67175357
63Diastasis recti (HP:0001540)2.66472573
64Abnormality of the nasal septum (HP:0000419)2.60904434
65Congenital sensorineural hearing impairment (HP:0008527)2.59041060
66Abnormality of the lumbar spine (HP:0100712)2.58821148
67Hepatoblastoma (HP:0002884)2.57228583
68Alacrima (HP:0000522)2.54929148
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52550729
70Hypophosphatemic rickets (HP:0004912)2.52360358
71Insidious onset (HP:0003587)2.49623706
72Termporal pattern (HP:0011008)2.49623706
73Lip pit (HP:0100267)2.49589202
74Aplasia/Hypoplasia involving the musculature (HP:0001460)2.49454411
75Mitral stenosis (HP:0001718)2.49377559
76Cardiovascular calcification (HP:0011915)2.49147936
77Aplasia/Hypoplasia affecting the retina (HP:0008061)2.48950425
78Abnormal foot bone ossification (HP:0010675)2.48122196
79Limited elbow extension (HP:0001377)2.48011002
80Hypoglycemic coma (HP:0001325)2.46022346
81Purpura (HP:0000979)2.45049256
82Abnormality of the duodenum (HP:0002246)2.43447748
83Abnormality of the wing of the ilium (HP:0011867)2.40000488
84Capillary hemangiomas (HP:0005306)2.39787880
85Amniotic constriction ring (HP:0009775)2.39622464
86Abnormality of placental membranes (HP:0011409)2.39622464
87Flared iliac wings (HP:0002869)2.39230396
88Abnormality of midbrain morphology (HP:0002418)2.37649528
89Molar tooth sign on MRI (HP:0002419)2.37649528
90Systemic lupus erythematosus (HP:0002725)2.36021234
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.35500242
92Aplasia of the musculature (HP:0100854)2.34109938
93Carpal bone hypoplasia (HP:0001498)2.32859362
94Abnormality of endocrine pancreas physiology (HP:0012093)2.32616227
95Abnormality of the pancreatic islet cells (HP:0006476)2.32616227
96Myelodysplasia (HP:0002863)2.32522817
97Prostate neoplasm (HP:0100787)2.31842438
98Acute myeloid leukemia (HP:0004808)2.28739706
99Renal duplication (HP:0000075)2.27232908
100Premature ovarian failure (HP:0008209)2.25696388
101Abnormality of the epiphysis of the femoral head (HP:0010574)2.25117183
102Cholecystitis (HP:0001082)2.24517711
103Abnormal gallbladder physiology (HP:0012438)2.24517711
104Clubbing of toes (HP:0100760)2.24280881
105Subacute progressive viral hepatitis (HP:0006572)2.24062020
106Broad palm (HP:0001169)2.22387416
107Wide nose (HP:0000445)2.21912374
108Skin nodule (HP:0200036)2.20533642
109Steppage gait (HP:0003376)2.20317219
110Abnormality of the acetabulum (HP:0003170)2.20307161
111Conjugated hyperbilirubinemia (HP:0002908)2.18409299
112Nephroblastoma (Wilms tumor) (HP:0002667)2.18023257
113Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17813052
114Abnormality of the intrinsic pathway (HP:0010989)2.17783499
115Absent epiphyses (HP:0010577)2.16019564
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16019564
117Primary amenorrhea (HP:0000786)2.15959310
118Impaired pain sensation (HP:0007328)2.15678560
119Abnormality of pain sensation (HP:0010832)2.15678560
120Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15320934
121Rhabdomyosarcoma (HP:0002859)2.14790512
122Abnormality of the femoral head (HP:0003368)2.14610312
123Fat malabsorption (HP:0002630)2.14531148
124Gingival bleeding (HP:0000225)2.13398761
125Abnormality of femoral epiphyses (HP:0006499)2.12610341
126Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.12610341
127Embryonal renal neoplasm (HP:0011794)2.10463064
128Abnormality of the carotid arteries (HP:0005344)2.09242719
129Protrusio acetabuli (HP:0003179)2.09193950
130Facial hemangioma (HP:0000329)2.09015845
131Abnormality of incisor morphology (HP:0011063)2.08707817
132Hypoalphalipoproteinemia (HP:0003233)2.07225107
133Abnormality of chromosome segregation (HP:0002916)2.05687981
134Intrahepatic cholestasis (HP:0001406)2.05092538
135Hepatocellular carcinoma (HP:0001402)2.03914853
136Secondary amenorrhea (HP:0000869)2.03140440
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02764664
138Cupped ribs (HP:0000887)2.01050915
139Conical tooth (HP:0000698)2.00062612
140Deep venous thrombosis (HP:0002625)10.4264457
141Neonatal death (HP:0003811)1.99738780
142Thyroid carcinoma (HP:0002890)1.99415221
143Sloping forehead (HP:0000340)1.98504793
144Heterotopia (HP:0002282)1.96351543
145Enlarged kidneys (HP:0000105)1.95007769
146Chronic hepatic failure (HP:0100626)1.93063061
147Absent radius (HP:0003974)1.93051648
148Overlapping toe (HP:0001845)1.92488135
149Erectile abnormalities (HP:0100639)1.92268648
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92069337
151Supernumerary spleens (HP:0009799)1.91834795
152Decreased lacrimation (HP:0000633)1.90340412
153Myocardial infarction (HP:0001658)1.88730153
154Poikilocytosis (HP:0004447)1.88152662
155Abnormality of the alveolar ridges (HP:0006477)1.87777796
156Aplasia involving forearm bones (HP:0009822)1.86050559
157Absent forearm bone (HP:0003953)1.86050559
158Coxa vara (HP:0002812)1.83711558
159Abnormality of the Achilles tendon (HP:0005109)1.82506324
160Widely patent fontanelles and sutures (HP:0004492)1.81422102
161Anosmia (HP:0000458)1.81138127
162Arthropathy (HP:0003040)1.81050020
163Duplicated collecting system (HP:0000081)1.79537558
164Abnormal lung lobation (HP:0002101)1.78452347
165Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77900623
166Metaphyseal irregularity (HP:0003025)1.77316159
167Triphalangeal thumb (HP:0001199)1.76785385
168Impaired proprioception (HP:0010831)1.76263219
169Hypoplastic iliac wings (HP:0002866)1.76079186
170Rickets (HP:0002748)1.75267644
171Blue irides (HP:0000635)1.74994898
172Anal stenosis (HP:0002025)1.74766854
173Pulmonary fibrosis (HP:0002206)1.74523828
174Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74216454
175Abnormality of the lacrimal duct (HP:0011481)1.73031336
176Facial shape deformation (HP:0011334)1.71763354
177Potter facies (HP:0002009)1.71763354
178Aganglionic megacolon (HP:0002251)1.70596697
179Thrombophlebitis (HP:0004418)1.70544948
180Absent septum pellucidum (HP:0001331)1.70529343
181Type 2 muscle fiber atrophy (HP:0003554)1.69467499
182Wrist flexion contracture (HP:0001239)1.68651449
183Submucous cleft hard palate (HP:0000176)1.65992819
184Abnormality of the renal collecting system (HP:0004742)1.65612019
185Abnormality of the fingertips (HP:0001211)1.64541595
18611 pairs of ribs (HP:0000878)1.61954441
187Vertebral compression fractures (HP:0002953)1.61498565
188Nephritis (HP:0000123)1.61014616
189Biconcave vertebral bodies (HP:0004586)1.60890018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.07592596
2FGFR46.00251155
3LATS14.25430751
4FGFR34.19593759
5LATS24.16407139
6MAP3K63.91709140
7ICK3.77877099
8STK38L3.56107749
9ERBB43.23629621
10EIF2AK12.98779215
11PLK42.84737640
12WNK42.76057726
13TTK2.65406378
14TRIB32.59896236
15BUB12.52201633
16KSR22.43430436
17PRKD32.42247478
18TYRO32.30142791
19MAP3K42.29069259
20MAP2K72.27937151
21CDK82.23398074
22TAOK32.20855807
23MATK2.13736749
24PKN22.12842492
25CDC72.09781890
26MAPK132.08342523
27BRAF2.03798288
28MAP3K121.88975124
29STK241.86285971
30EPHA21.83726277
31EEF2K1.82407588
32MOS1.81338285
33PDGFRA1.79558995
34FGFR11.79224901
35FGFR21.72204413
36MAP2K41.64798637
37DYRK21.64470691
38BMPR21.63857642
39STK31.53243921
40MUSK1.50748948
41SIK21.49818955
42SIK11.45179967
43IRAK31.43343380
44MAP3K111.43213893
45MST1R1.41132408
46WNK11.40927496
47PLK11.39891149
48RIPK11.33380050
49MAP3K21.32744919
50CHEK21.32713057
51MAP3K131.24266530
52ERN11.21674264
53STK101.19407660
54RAF11.15742864
55BMPR1B1.14558910
56NEK21.14006049
57ERBB21.11315384
58PLK31.10857095
59SCYL21.07320491
60EIF2AK21.05616453
61MAP3K91.05185311
62NEK11.04764557
63KSR11.03328582
64CDK91.00735458
65SMG11.00412549
66TRPM70.99034926
67NEK90.96306882
68OBSCN0.94739965
69PLK20.93513052
70PDPK10.90642528
71SGK20.90485651
72MAP3K80.90182265
73MELK0.88755231
74AURKB0.86946267
75RET0.84435419
76MAPKAPK30.81087820
77PBK0.80455913
78ARAF0.80088914
79STK380.80004158
80BRSK20.79845941
81PINK10.79183253
82TAOK10.74190039
83DYRK1B0.72534465
84BRD40.72192056
85AURKA0.71893523
86MAP3K50.68679160
87MAPKAPK50.67727091
88RPS6KA40.67064401
89DDR20.66479215
90CSNK1E0.66384690
91AKT30.64869082
92MTOR0.64391984
93EIF2AK30.62758436
94ATM0.61755188
95PTK20.61115049
96PDK10.60892593
97CHEK10.60517633
98RPS6KB10.59835452
99PRKD20.59727211
100NUAK10.59659832
101ABL20.56029319
102PAK60.54256330
103FGR0.54051528
104MAP3K10.53310666
105SGK30.52077666
106CDC42BPA0.51922700
107ATR0.50647530
108PNCK0.49707724
109STK390.48859462
110NTRK30.48782991
111MET0.48191176
112PTK60.47268965
113NTRK20.46235879
114STK40.45095984
115BCR0.45012329
116YES10.44685601
117SGK10.44410744
118NLK0.43884352
119CDK40.43834285
120ZAK0.43516945
121ACVR1B0.43267213
122PIK3CA0.43169023
123SGK4940.43105716
124SGK2230.43105716
125BRSK10.42721742
126TGFBR20.42570681
127CSNK1G20.39349586
128DMPK0.38336714
129CDK60.37684924
130MARK20.37568909
131ALK0.37037490
132RPS6KB20.36356245
133TSSK60.35727205
134CSNK1G10.34436318
135HIPK20.34111600
136PRKAA10.33911816
137SRPK10.33434897
138MKNK20.31327665
139CDK70.30794026
140CSNK2A20.30405334
141NME20.30122751
142PRKAA20.29873706
143MKNK10.29650285
144CSNK1D0.29510193
145WEE10.28624194
146EPHA30.28385368
147MAP3K30.27871086
148BMX0.27280529
149MAP2K60.26902918
150CDK20.26310222
151MAPK110.25983706
152CDK10.25587402
153PAK40.25299192
154ABL10.24335832
155MAPK140.23667747
156MAPKAPK20.23295286
157NME10.22133764
158CSNK2A10.22073971
159NEK60.21136070
160CAMK1D0.19220431

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.97327553
2Homologous recombination_Homo sapiens_hsa034404.34043835
3Fanconi anemia pathway_Homo sapiens_hsa034603.93888027
4Cell cycle_Homo sapiens_hsa041103.93840336
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.76776193
6Non-homologous end-joining_Homo sapiens_hsa034503.16381123
7Basal transcription factors_Homo sapiens_hsa030223.03302762
8RNA degradation_Homo sapiens_hsa030182.99926259
9Steroid biosynthesis_Homo sapiens_hsa001002.95429864
10Fat digestion and absorption_Homo sapiens_hsa049752.85792395
11Ovarian steroidogenesis_Homo sapiens_hsa049132.84849661
12Fatty acid biosynthesis_Homo sapiens_hsa000612.72814985
13Base excision repair_Homo sapiens_hsa034102.54466567
14DNA replication_Homo sapiens_hsa030302.44141674
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42638187
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.33033333
17Oocyte meiosis_Homo sapiens_hsa041142.32570934
18RNA polymerase_Homo sapiens_hsa030202.31740980
19Vitamin B6 metabolism_Homo sapiens_hsa007502.27242626
20Other glycan degradation_Homo sapiens_hsa005112.23337501
21Arginine biosynthesis_Homo sapiens_hsa002202.20307344
22Fatty acid metabolism_Homo sapiens_hsa012122.18897218
23Vitamin digestion and absorption_Homo sapiens_hsa049772.17828445
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05839783
25Dorso-ventral axis formation_Homo sapiens_hsa043202.02647175
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99599395
27RNA transport_Homo sapiens_hsa030131.94396953
28Fatty acid degradation_Homo sapiens_hsa000711.92965434
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92863228
30Circadian rhythm_Homo sapiens_hsa047101.89424280
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.82266483
32PPAR signaling pathway_Homo sapiens_hsa033201.82262441
33Pancreatic cancer_Homo sapiens_hsa052121.81108459
34Linoleic acid metabolism_Homo sapiens_hsa005911.81001398
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79046538
36N-Glycan biosynthesis_Homo sapiens_hsa005101.77889785
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.77466793
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77155026
39Phenylalanine metabolism_Homo sapiens_hsa003601.68977979
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67244844
41Mismatch repair_Homo sapiens_hsa034301.64146828
42Histidine metabolism_Homo sapiens_hsa003401.63519646
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62988472
44p53 signaling pathway_Homo sapiens_hsa041151.61960394
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.58907556
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57771675
47Fructose and mannose metabolism_Homo sapiens_hsa000511.57048152
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56206794
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54684291
50Starch and sucrose metabolism_Homo sapiens_hsa005001.54415151
51TGF-beta signaling pathway_Homo sapiens_hsa043501.54385537
52Biosynthesis of amino acids_Homo sapiens_hsa012301.54290305
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53286239
54GnRH signaling pathway_Homo sapiens_hsa049121.47773607
55Ether lipid metabolism_Homo sapiens_hsa005651.45870720
56mRNA surveillance pathway_Homo sapiens_hsa030151.41975087
57Nucleotide excision repair_Homo sapiens_hsa034201.39816767
58Arginine and proline metabolism_Homo sapiens_hsa003301.36524130
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27272484
60Hippo signaling pathway_Homo sapiens_hsa043901.25971595
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25663796
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24903605
63ABC transporters_Homo sapiens_hsa020101.21534461
64Adherens junction_Homo sapiens_hsa045201.21396101
65MicroRNAs in cancer_Homo sapiens_hsa052061.18859962
66Colorectal cancer_Homo sapiens_hsa052101.17451523
67Prolactin signaling pathway_Homo sapiens_hsa049171.15938063
68Carbon metabolism_Homo sapiens_hsa012001.15589085
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14601615
70Thyroid hormone synthesis_Homo sapiens_hsa049181.13804456
71One carbon pool by folate_Homo sapiens_hsa006701.13588962
72Bile secretion_Homo sapiens_hsa049761.07631240
73Lysine degradation_Homo sapiens_hsa003101.03128460
74Nicotine addiction_Homo sapiens_hsa050331.00481418
75Galactose metabolism_Homo sapiens_hsa000520.99922292
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99309590
77Pyruvate metabolism_Homo sapiens_hsa006200.98196727
78Pyrimidine metabolism_Homo sapiens_hsa002400.98010866
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.94248740
80Fatty acid elongation_Homo sapiens_hsa000620.93506016
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92467295
82Thyroid cancer_Homo sapiens_hsa052160.92349715
83Propanoate metabolism_Homo sapiens_hsa006400.92239218
84Small cell lung cancer_Homo sapiens_hsa052220.91271434
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87385566
86Long-term depression_Homo sapiens_hsa047300.86982207
87Renin-angiotensin system_Homo sapiens_hsa046140.86715240
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.83149163
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.82658247
90Staphylococcus aureus infection_Homo sapiens_hsa051500.80500562
91ErbB signaling pathway_Homo sapiens_hsa040120.78644064
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77761845
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.76481110
94Choline metabolism in cancer_Homo sapiens_hsa052310.75443938
95Peroxisome_Homo sapiens_hsa041460.74423024
96Butanoate metabolism_Homo sapiens_hsa006500.72889593
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72474487
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69855616
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68216199
100Renal cell carcinoma_Homo sapiens_hsa052110.67882526
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67562692
102Purine metabolism_Homo sapiens_hsa002300.67043109
103Insulin resistance_Homo sapiens_hsa049310.66618224
104Chemical carcinogenesis_Homo sapiens_hsa052040.66348109
105Serotonergic synapse_Homo sapiens_hsa047260.65899094
106Glucagon signaling pathway_Homo sapiens_hsa049220.64316492
107Prion diseases_Homo sapiens_hsa050200.63664367
108Arachidonic acid metabolism_Homo sapiens_hsa005900.63467067
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62758351
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.61546213
111Endometrial cancer_Homo sapiens_hsa052130.61346323
112Ras signaling pathway_Homo sapiens_hsa040140.61052961
113HTLV-I infection_Homo sapiens_hsa051660.59369974
114Herpes simplex infection_Homo sapiens_hsa051680.59366373
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59320746
116Melanoma_Homo sapiens_hsa052180.58269163
117Pentose phosphate pathway_Homo sapiens_hsa000300.58204039
118Tight junction_Homo sapiens_hsa045300.57982135
119Inositol phosphate metabolism_Homo sapiens_hsa005620.57692239
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.57675300
121Sphingolipid metabolism_Homo sapiens_hsa006000.57403171
122Retinol metabolism_Homo sapiens_hsa008300.55935465
123Dilated cardiomyopathy_Homo sapiens_hsa054140.53935540
124FoxO signaling pathway_Homo sapiens_hsa040680.52453770
125Glycerolipid metabolism_Homo sapiens_hsa005610.51816332
126Glutathione metabolism_Homo sapiens_hsa004800.51200192
127Tyrosine metabolism_Homo sapiens_hsa003500.50248101
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49847119
129Wnt signaling pathway_Homo sapiens_hsa043100.49377577
130Melanogenesis_Homo sapiens_hsa049160.48667410
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47554750
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46605180
133Insulin signaling pathway_Homo sapiens_hsa049100.45814371
134Chronic myeloid leukemia_Homo sapiens_hsa052200.43503998
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43163318
136Hepatitis B_Homo sapiens_hsa051610.43038853
137Epstein-Barr virus infection_Homo sapiens_hsa051690.42676950
138MAPK signaling pathway_Homo sapiens_hsa040100.42448209
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42053543
140Glutamatergic synapse_Homo sapiens_hsa047240.41220904
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40387908
142Pathways in cancer_Homo sapiens_hsa052000.39469215
143AMPK signaling pathway_Homo sapiens_hsa041520.38968641
144Vibrio cholerae infection_Homo sapiens_hsa051100.38399390
145TNF signaling pathway_Homo sapiens_hsa046680.37825596
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37010178
147Metabolic pathways_Homo sapiens_hsa011000.36602086
148Huntingtons disease_Homo sapiens_hsa050160.35671979
149Taste transduction_Homo sapiens_hsa047420.35487203
150Mineral absorption_Homo sapiens_hsa049780.35033180
151Nitrogen metabolism_Homo sapiens_hsa009100.33426710
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33390726
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33181364
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.33167323
155Estrogen signaling pathway_Homo sapiens_hsa049150.32160738
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32085638
157Non-small cell lung cancer_Homo sapiens_hsa052230.31827771
158Spliceosome_Homo sapiens_hsa030400.31649573
159Tryptophan metabolism_Homo sapiens_hsa003800.31584615
160Shigellosis_Homo sapiens_hsa051310.30916673
161VEGF signaling pathway_Homo sapiens_hsa043700.30706306
162Hedgehog signaling pathway_Homo sapiens_hsa043400.30449467
163Sulfur relay system_Homo sapiens_hsa041220.30295853
164mTOR signaling pathway_Homo sapiens_hsa041500.30177895
165Proteoglycans in cancer_Homo sapiens_hsa052050.29752145
166Influenza A_Homo sapiens_hsa051640.29744170
167Rap1 signaling pathway_Homo sapiens_hsa040150.29613409
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27979509
169HIF-1 signaling pathway_Homo sapiens_hsa040660.27479220
170Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26821292
171Basal cell carcinoma_Homo sapiens_hsa052170.26777051
172ECM-receptor interaction_Homo sapiens_hsa045120.26605960
173Prostate cancer_Homo sapiens_hsa052150.26190320
174Bladder cancer_Homo sapiens_hsa052190.26119856
175Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25948619
176Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25647748
177Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25173157
178Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25079257
179Phospholipase D signaling pathway_Homo sapiens_hsa040720.25029433
180Olfactory transduction_Homo sapiens_hsa047400.24225090
181Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23748811
182Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23493382
183Toxoplasmosis_Homo sapiens_hsa051450.22371096
184Lysosome_Homo sapiens_hsa041420.17951566

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