DHRS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.89919593
2L-phenylalanine catabolic process (GO:0006559)6.89919593
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80087747
4L-phenylalanine metabolic process (GO:0006558)6.80087747
5aromatic amino acid family catabolic process (GO:0009074)6.20805946
6glyoxylate metabolic process (GO:0046487)5.91348325
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67329611
8tryptophan catabolic process (GO:0006569)5.61160585
9indole-containing compound catabolic process (GO:0042436)5.61160585
10indolalkylamine catabolic process (GO:0046218)5.61160585
11lysine metabolic process (GO:0006553)5.57140767
12lysine catabolic process (GO:0006554)5.57140767
13kynurenine metabolic process (GO:0070189)5.53026719
14alpha-linolenic acid metabolic process (GO:0036109)5.31768525
15bile acid biosynthetic process (GO:0006699)5.31290132
16tryptophan metabolic process (GO:0006568)5.30603633
17cysteine metabolic process (GO:0006534)5.30125241
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.20228750
19sulfur amino acid catabolic process (GO:0000098)5.11343751
20urea cycle (GO:0000050)4.91994916
21urea metabolic process (GO:0019627)4.91994916
22serine family amino acid catabolic process (GO:0009071)4.83232651
23high-density lipoprotein particle remodeling (GO:0034375)4.83013162
24amino-acid betaine metabolic process (GO:0006577)4.78486169
25negative regulation of fibrinolysis (GO:0051918)4.77437550
26regulation of triglyceride catabolic process (GO:0010896)4.62655824
27peptidyl-glutamic acid carboxylation (GO:0017187)4.58791336
28protein carboxylation (GO:0018214)4.58791336
29nitrogen cycle metabolic process (GO:0071941)4.57699643
30homocysteine metabolic process (GO:0050667)4.55531068
31aromatic amino acid family metabolic process (GO:0009072)4.54649160
32regulation of fibrinolysis (GO:0051917)4.50832198
33cellular ketone body metabolic process (GO:0046950)4.49539838
34bile acid metabolic process (GO:0008206)4.47958122
35complement activation, alternative pathway (GO:0006957)4.46799054
36regulation of cholesterol esterification (GO:0010872)4.44560107
37alpha-amino acid catabolic process (GO:1901606)4.42038292
38regulation of protein activation cascade (GO:2000257)4.40732022
39glycine metabolic process (GO:0006544)4.28348823
40ethanol oxidation (GO:0006069)4.22911441
41triglyceride homeostasis (GO:0070328)4.22780166
42acylglycerol homeostasis (GO:0055090)4.22780166
43short-chain fatty acid metabolic process (GO:0046459)4.21346514
44serine family amino acid metabolic process (GO:0009069)4.21145512
45fatty acid beta-oxidation (GO:0006635)4.19119018
46protein-lipid complex remodeling (GO:0034368)4.18429615
47macromolecular complex remodeling (GO:0034367)4.18429615
48plasma lipoprotein particle remodeling (GO:0034369)4.18429615
49negative regulation of sterol transport (GO:0032372)4.17751161
50negative regulation of cholesterol transport (GO:0032375)4.17751161
51reverse cholesterol transport (GO:0043691)4.16399773
52cellular amino acid catabolic process (GO:0009063)4.15816302
53tyrosine metabolic process (GO:0006570)4.15532396
54regulation of complement activation (GO:0030449)4.12114943
55aspartate family amino acid catabolic process (GO:0009068)4.08893120
56phospholipid efflux (GO:0033700)4.08015065
57drug transmembrane transport (GO:0006855)4.05080510
58serine family amino acid biosynthetic process (GO:0009070)4.04203391
592-oxoglutarate metabolic process (GO:0006103)4.03518189
60fatty acid oxidation (GO:0019395)4.00664994
61cellular modified amino acid catabolic process (GO:0042219)3.99653724
62coenzyme catabolic process (GO:0009109)3.98972879
63benzene-containing compound metabolic process (GO:0042537)3.98453378
64plasma lipoprotein particle clearance (GO:0034381)3.98216939
65drug catabolic process (GO:0042737)3.96296976
66indolalkylamine metabolic process (GO:0006586)3.95537126
67acetyl-CoA metabolic process (GO:0006084)3.95416565
68lipid oxidation (GO:0034440)3.92536888
69valine metabolic process (GO:0006573)3.92397942
70urate metabolic process (GO:0046415)3.91492989
71carnitine metabolic process (GO:0009437)3.88860006
72ketone body metabolic process (GO:1902224)3.87840144
73fatty acid catabolic process (GO:0009062)3.87269097
74aldehyde catabolic process (GO:0046185)3.85684924
75glutamate metabolic process (GO:0006536)3.85193879
76cellular glucuronidation (GO:0052695)3.84712108
77carboxylic acid catabolic process (GO:0046395)3.84504659
78organic acid catabolic process (GO:0016054)3.84504659
79monocarboxylic acid catabolic process (GO:0072329)3.82917939
80amine catabolic process (GO:0009310)3.81794769
81cellular biogenic amine catabolic process (GO:0042402)3.81794769
82imidazole-containing compound metabolic process (GO:0052803)3.73919984
83bile acid and bile salt transport (GO:0015721)3.73253135
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.70158097
85positive regulation of lipoprotein lipase activity (GO:0051006)3.61926689
86positive regulation of triglyceride lipase activity (GO:0061365)3.61926689
87plasma lipoprotein particle assembly (GO:0034377)3.58888198
88positive regulation of lipid catabolic process (GO:0050996)3.57658323
89cholesterol efflux (GO:0033344)3.56056441
90response to nitrosative stress (GO:0051409)3.53690050
91branched-chain amino acid catabolic process (GO:0009083)3.52894420
92arginine metabolic process (GO:0006525)3.52500708
93dicarboxylic acid biosynthetic process (GO:0043650)3.51826322
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.51421218
95regulation of cholesterol homeostasis (GO:2000188)3.50175966
96cofactor catabolic process (GO:0051187)3.50059414
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.47216795
98uronic acid metabolic process (GO:0006063)3.45284864
99glucuronate metabolic process (GO:0019585)3.45284864
100drug transport (GO:0015893)3.45249947
101cholesterol homeostasis (GO:0042632)3.45001831
102branched-chain amino acid metabolic process (GO:0009081)3.43368398
103NADH metabolic process (GO:0006734)3.22141586
104immunoglobulin mediated immune response (GO:0016064)3.12111620
105purine deoxyribonucleotide catabolic process (GO:0009155)3.05121271
106fat-soluble vitamin biosynthetic process (GO:0042362)3.02095637
107epoxygenase P450 pathway (GO:0019373)2.91200706
108angiotensin maturation (GO:0002003)2.86621396
109deoxyribonucleotide catabolic process (GO:0009264)2.79991854
110pinocytosis (GO:0006907)2.78921417
111glycosphingolipid catabolic process (GO:0046479)2.78635135
112pentose-phosphate shunt (GO:0006098)2.78361099
113GDP-mannose metabolic process (GO:0019673)2.77934638
114positive regulation of fatty acid biosynthetic process (GO:0045723)2.71221134
115xenobiotic catabolic process (GO:0042178)2.69163300
116negative regulation of myeloid cell apoptotic process (GO:0033033)2.63897800
117deoxyribose phosphate catabolic process (GO:0046386)2.62358667
118cellular response to arsenic-containing substance (GO:0071243)2.62208107
119response to peptidoglycan (GO:0032494)2.61454572
120pentose metabolic process (GO:0019321)2.61094735
121fructose metabolic process (GO:0006000)2.60640069
122glycolipid catabolic process (GO:0019377)2.57856314
123daunorubicin metabolic process (GO:0044597)2.54877097
124polyketide metabolic process (GO:0030638)2.54877097
125doxorubicin metabolic process (GO:0044598)2.54877097
126iron-sulfur cluster assembly (GO:0016226)2.54670532
127metallo-sulfur cluster assembly (GO:0031163)2.54670532
128antigen processing and presentation of endogenous antigen (GO:0019883)2.53991904
129oxaloacetate metabolic process (GO:0006107)2.53839939
130NADPH regeneration (GO:0006740)2.51752244
131neutrophil activation involved in immune response (GO:0002283)2.51660443
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50926299
133amyloid precursor protein catabolic process (GO:0042987)2.49681304
134blood coagulation, intrinsic pathway (GO:0007597)2.49144490
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.47667937
136regulation of superoxide anion generation (GO:0032928)2.44901585
137purine nucleotide salvage (GO:0032261)2.41933127
138barbed-end actin filament capping (GO:0051016)2.37948146
139oxidative phosphorylation (GO:0006119)2.37531931
140glycoside metabolic process (GO:0016137)2.36486554
141nucleotide salvage (GO:0043173)2.35908805
142acute-phase response (GO:0006953)2.35309640
143fibrinolysis (GO:0042730)2.35300122
144drug metabolic process (GO:0017144)2.33793905
145glucose catabolic process (GO:0006007)2.33187157
146cellular response to zinc ion (GO:0071294)2.32555120
147quinone biosynthetic process (GO:1901663)2.32275986
148protein maturation by protein folding (GO:0022417)2.31993512
149peptide catabolic process (GO:0043171)2.31786264
150lipoxygenase pathway (GO:0019372)2.31537712
151amino sugar catabolic process (GO:0046348)2.31052646
152B cell mediated immunity (GO:0019724)2.30010324
153negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.28787027
154positive regulation of antigen processing and presentation (GO:0002579)2.28620971
155quinone metabolic process (GO:1901661)2.27469161
156aminoglycoside antibiotic metabolic process (GO:0030647)2.23226565
157negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.22818011
158oligosaccharide catabolic process (GO:0009313)2.22707799
159mature B cell differentiation involved in immune response (GO:0002313)2.21492337
160ethanol metabolic process (GO:0006067)2.21253251
161NADP metabolic process (GO:0006739)2.20680755
162antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20669899
163UV protection (GO:0009650)2.20142838
164pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.19859076
165positive regulation of cellular amine metabolic process (GO:0033240)2.18659644
166omega-hydroxylase P450 pathway (GO:0097267)2.18420660
167nucleoside diphosphate biosynthetic process (GO:0009133)2.18320116
168response to interferon-beta (GO:0035456)2.17534218
169heme metabolic process (GO:0042168)2.17200203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.46993236
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.63894894
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.08463177
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.89943660
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.61139193
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.75286125
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.37772377
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76384059
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.64150496
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.37532812
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85609891
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44987113
13VDR_21846776_ChIP-Seq_THP-1_Human2.37603541
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30648662
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7409266
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91014893
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90281442
18GATA1_22025678_ChIP-Seq_K562_Human1.86186306
19CLOCK_20551151_ChIP-Seq_293T_Human1.85906232
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.82736325
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79122095
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77849836
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69326577
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.66128814
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.58479226
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56725641
27VDR_24763502_ChIP-Seq_THP-1_Human1.56300067
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55236522
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54711932
30SPI1_23547873_ChIP-Seq_NB4_Human1.49129971
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48317488
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41239440
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40505739
34* CTCF_26484167_Chip-Seq_Bcells_Mouse1.33567751
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32878496
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32396040
37P68_20966046_ChIP-Seq_HELA_Human1.32354826
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32164155
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31716820
40MYC_22102868_ChIP-Seq_BL_Human1.31527172
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.30779288
42PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30164777
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29095820
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27078575
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26619245
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25115121
47* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24049235
48UTX_26944678_Chip-Seq_JUKART_Human1.22992485
49SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22488538
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22304270
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22251487
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21766916
53* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20989583
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20719346
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.20389794
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20330553
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20261215
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.20214576
59MAF_26560356_Chip-Seq_TH1_Human1.17718153
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16286219
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15758988
62ZNF263_19887448_ChIP-Seq_K562_Human1.14617715
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.14392933
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14335578
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13691826
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13064981
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12834535
68MAF_26560356_Chip-Seq_TH2_Human1.12252717
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.11984699
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11677555
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11604509
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11287153
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11275788
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09779958
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.08736472
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08423752
77GABP_19822575_ChIP-Seq_HepG2_Human1.07422875
78SPI1_20517297_ChIP-Seq_HL60_Human1.05278140
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05204931
80STAT1_20625510_ChIP-Seq_HELA_Human1.03953058
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03454067
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03414340
83XRN2_22483619_ChIP-Seq_HELA_Human1.02664592
84SA1_27219007_Chip-Seq_Bcells_Human1.02608143
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01720178
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01244343
87DCP1A_22483619_ChIP-Seq_HELA_Human1.00731383
88* IRF8_22096565_ChIP-ChIP_GC-B_Human1.00470439
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99637552
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99304561
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98627553
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98133864
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97819542
94GATA4_25053715_ChIP-Seq_YYC3_Human0.97360944
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93095920
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92965556
97HTT_18923047_ChIP-ChIP_STHdh_Human0.90659770
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89896494
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84612239
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82565065
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82296296
102AR_21909140_ChIP-Seq_LNCAP_Human0.81343286
103LXR_22292898_ChIP-Seq_THP-1_Human0.80384899
104* SRF_21415370_ChIP-Seq_HL-1_Mouse0.80306138
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79380378
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.78252008
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76382276
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76147470
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73814838
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.71316560
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70604833
112E2F1_18555785_ChIP-Seq_MESCs_Mouse0.70314824
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68503915
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.68382898
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67452348
116GATA6_25053715_ChIP-Seq_YYC3_Human0.65987233
117CREB1_15753290_ChIP-ChIP_HEK293T_Human0.65780226
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64262893
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63794566
120CEBPB_22108803_ChIP-Seq_LS180_Human0.63674461
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63546425
122AR_20517297_ChIP-Seq_VCAP_Human0.63177038
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62300837
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.60929291
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.59921989
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.59805708
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57552135
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.57386442
129BCOR_27268052_Chip-Seq_Bcells_Human0.56923474
130MYC_18358816_ChIP-ChIP_MESCs_Mouse0.56565933
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.55588965
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55514259
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.55361529
134RACK7_27058665_Chip-Seq_MCF-7_Human0.55136616
135BCL6_27268052_Chip-Seq_Bcells_Human0.54972586
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.54894131
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.54624307
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.53498080
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52650076
140EGR1_19032775_ChIP-ChIP_M12_Human0.52211177
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.51415735
142CTCF_21964334_Chip-Seq_Bcells_Human0.51323398
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.51257088
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.51257088
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51114338
146GATA1_19941826_ChIP-Seq_K562_Human0.50863495
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.50792100
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.49696062
149ERG_20517297_ChIP-Seq_VCAP_Human0.48939532
150* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.48450570
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.48267546
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.48073976
153* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.48012091
154CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47942317
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47920656
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.47586091
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.47578290
158P300_27268052_Chip-Seq_Bcells_Human0.47575136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.85972207
2MP0005360_urolithiasis7.24398084
3MP0005085_abnormal_gallbladder_physiolo5.76933984
4MP0005365_abnormal_bile_salt5.69934256
5MP0008875_abnormal_xenobiotic_pharmacok4.59373077
6MP0003806_abnormal_nucleotide_metabolis4.37996398
7MP0003252_abnormal_bile_duct3.61820580
8MP0010329_abnormal_lipoprotein_level3.25798531
9MP0009840_abnormal_foam_cell3.10159861
10MP0005332_abnormal_amino_acid2.98451063
11MP0003195_calcinosis2.82682470
12MP0005083_abnormal_biliary_tract2.76708899
13MP0001666_abnormal_nutrient_absorption2.55795589
14MP0003191_abnormal_cellular_cholesterol2.34596195
15MP0002148_abnormal_hypersensitivity_rea2.28152683
16MP0001835_abnormal_antigen_presentation2.26885041
17MP0004019_abnormal_vitamin_homeostasis2.16838195
18MP0002138_abnormal_hepatobiliary_system2.16234428
19MP0009785_altered_susceptibility_to2.14351527
20MP0000609_abnormal_liver_physiology2.09781578
21MP0002118_abnormal_lipid_homeostasis2.03547890
22MP0005025_abnormal_response_to1.96171921
23MP0005319_abnormal_enzyme/_coenzyme1.95354394
24MP0002419_abnormal_innate_immunity1.88868448
25MP0003303_peritoneal_inflammation1.83349366
26MP0009643_abnormal_urine_homeostasis1.75903727
27MP0005000_abnormal_immune_tolerance1.75375689
28MP0009333_abnormal_splenocyte_physiolog1.74839231
29MP0003172_abnormal_lysosome_physiology1.70960311
30MP0003186_abnormal_redox_activity1.68670548
31MP0001764_abnormal_homeostasis1.68476525
32MP0001790_abnormal_immune_system1.65116365
33MP0005387_immune_system_phenotype1.65116365
34MP0005584_abnormal_enzyme/coenzyme_acti1.64214792
35MP0006082_CNS_inflammation1.58643572
36MP0006036_abnormal_mitochondrial_physio1.54599298
37MP0003868_abnormal_feces_composition1.46046793
38MP0002452_abnormal_antigen_presenting1.45995154
39MP0009278_abnormal_bone_marrow1.44850397
40MP0001800_abnormal_humoral_immune1.44149690
41MP0002723_abnormal_immune_serum1.43127322
42MP0000343_altered_response_to1.42350345
43MP0010155_abnormal_intestine_physiology1.41710214
44MP0000685_abnormal_immune_system1.39069896
45MP0005671_abnormal_response_to1.36735251
46MP0003656_abnormal_erythrocyte_physiolo1.36220887
47MP0001533_abnormal_skeleton_physiology1.33206083
48MP0005636_abnormal_mineral_homeostasis1.31928965
49MP0005166_decreased_susceptibility_to1.31692302
50MP0002420_abnormal_adaptive_immunity1.29410145
51MP0001819_abnormal_immune_cell1.29408971
52MP0009697_abnormal_copulation1.25451380
53MP0005451_abnormal_body_composition1.24721274
54MP0005670_abnormal_white_adipose1.21427158
55MP0000598_abnormal_liver_morphology1.20601603
56MP0005397_hematopoietic_system_phenotyp1.19114625
57MP0001545_abnormal_hematopoietic_system1.19114625
58MP0008260_abnormal_autophagy1.18548689
59MP0002837_dystrophic_cardiac_calcinosis1.16218710
60MP0000858_altered_metastatic_potential1.14041233
61MP0004043_abnormal_pH_regulation1.12109197
62MP0003705_abnormal_hypodermis_morpholog1.11909172
63MP0003183_abnormal_peptide_metabolism1.10354902
64MP0009764_decreased_sensitivity_to0.99757420
65MP0003011_delayed_dark_adaptation0.99710336
66MP0009763_increased_sensitivity_to0.99195014
67MP0008469_abnormal_protein_level0.98715858
68MP0000490_abnormal_crypts_of0.98690923
69MP0002405_respiratory_system_inflammati0.98676955
70MP0004130_abnormal_muscle_cell0.98259676
71MP0000716_abnormal_immune_system0.97096180
72MP0004510_myositis0.96638324
73MP0001756_abnormal_urination0.96240799
74MP0000465_gastrointestinal_hemorrhage0.94184519
75MP0009642_abnormal_blood_homeostasis0.94089667
76MP0000678_abnormal_parathyroid_gland0.93897079
77MP0005084_abnormal_gallbladder_morpholo0.93865211
78MP0005220_abnormal_exocrine_pancreas0.93705967
79MP0002078_abnormal_glucose_homeostasis0.92735792
80MP0000689_abnormal_spleen_morphology0.90214897
81MP0005647_abnormal_sex_gland0.89401265
82MP0004947_skin_inflammation0.87020831
83MP0002429_abnormal_blood_cell0.86597324
84MP0002971_abnormal_brown_adipose0.86308584
85MP0006035_abnormal_mitochondrial_morpho0.85556973
86MP0005165_increased_susceptibility_to0.84414509
87MP0005266_abnormal_metabolism0.83906182
88MP0008004_abnormal_stomach_pH0.83673077
89MP0005376_homeostasis/metabolism_phenot0.83167494
90MP0002722_abnormal_immune_system0.80468741
91MP0000604_amyloidosis0.79883482
92MP0005666_abnormal_adipose_tissue0.79752581
93MP0002398_abnormal_bone_marrow0.79382800
94MP0005408_hypopigmentation0.78607851
95MP0010368_abnormal_lymphatic_system0.78573710
96MP0002136_abnormal_kidney_physiology0.78259382
97MP0001849_ear_inflammation0.77523595
98MP0003866_abnormal_defecation0.76467127
99MP0000681_abnormal_thyroid_gland0.75778548
100MP0001873_stomach_inflammation0.75560967
101MP0005535_abnormal_body_temperature0.74478876
102MP0005334_abnormal_fat_pad0.74424489
103MP0003763_abnormal_thymus_physiology0.73787814
104MP0003279_aneurysm0.72267349
105MP0001542_abnormal_bone_strength0.72023477
106MP0002876_abnormal_thyroid_physiology0.71140219
107MP0002254_reproductive_system_inflammat0.70890843
108MP0001663_abnormal_digestive_system0.70882471
109MP0009765_abnormal_xenobiotic_induced0.67309318
110MP0004147_increased_porphyrin_level0.65813128
111MP0005330_cardiomyopathy0.65259799
112MP0003724_increased_susceptibility_to0.60818283
113MP0001661_extended_life_span0.59865729
114MP0001765_abnormal_ion_homeostasis0.57643654
115MP0005058_abnormal_lysosome_morphology0.56923677
116MP0005464_abnormal_platelet_physiology0.55231119
117MP0002928_abnormal_bile_duct0.53860445
118MP0005448_abnormal_energy_balance0.53057452
119MP0001853_heart_inflammation0.52767192
120MP0000230_abnormal_systemic_arterial0.51294827
121MP0009053_abnormal_anal_canal0.49768862
122MP0002970_abnormal_white_adipose0.48987326
123MP0009115_abnormal_fat_cell0.48770256
124MP0003953_abnormal_hormone_level0.47312244
125MP0002269_muscular_atrophy0.47167735
126MP0003638_abnormal_response/metabolism_0.47034918
127MP0003646_muscle_fatigue0.45193826
128MP0008873_increased_physiological_sensi0.45145119
129MP0004264_abnormal_extraembryonic_tissu0.42706756
130MP0009672_abnormal_birth_weight0.41664896
131MP0003300_gastrointestinal_ulcer0.40545309
132MP0001845_abnormal_inflammatory_respons0.40534581
133MP0002132_abnormal_respiratory_system0.40239543
134MP0003436_decreased_susceptibility_to0.39246473
135MP0001944_abnormal_pancreas_morphology0.39167784
136MP0002135_abnormal_kidney_morphology0.36447519
137MP0000639_abnormal_adrenal_gland0.36116252
138MP0005395_other_phenotype0.35862715
139MP0003221_abnormal_cardiomyocyte_apopto0.34109843
140MP0003329_amyloid_beta_deposits0.33758110
141MP0004782_abnormal_surfactant_physiolog0.33527478
142MP0000249_abnormal_blood_vessel0.32270335
143MP0003959_abnormal_lean_body0.32144758
144MP0005375_adipose_tissue_phenotype0.31944520
145MP0003075_altered_response_to0.30903535
146MP0004185_abnormal_adipocyte_glucose0.29244671
147MP0002796_impaired_skin_barrier0.29112658
148MP0005385_cardiovascular_system_phenoty0.28739440
149MP0001544_abnormal_cardiovascular_syste0.28739440
150MP0001243_abnormal_dermal_layer0.28399650

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.59394186
2Intrahepatic cholestasis (HP:0001406)6.13579721
3Deep venous thrombosis (HP:0002625)5.79694852
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.67250095
5Xanthomatosis (HP:0000991)5.43916810
6Hypobetalipoproteinemia (HP:0003563)5.24865444
7Prolonged partial thromboplastin time (HP:0003645)5.07616783
8Hypoglycemic coma (HP:0001325)4.86301456
9Hyperammonemia (HP:0001987)4.73726352
10Ketosis (HP:0001946)4.71036242
11Hyperlipoproteinemia (HP:0010980)4.52044891
12Hyperglycinuria (HP:0003108)4.48971768
13Hyperglycinemia (HP:0002154)4.24839784
14Abnormality of serine family amino acid metabolism (HP:0010894)4.22152574
15Abnormality of glycine metabolism (HP:0010895)4.22152574
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14937028
17Complement deficiency (HP:0004431)4.14402270
18Abnormality of fatty-acid metabolism (HP:0004359)4.13846295
19Ketoacidosis (HP:0001993)4.02524452
20Hypolipoproteinemia (HP:0010981)3.99695666
21Abnormality of glycolipid metabolism (HP:0010969)3.95562707
22Abnormality of liposaccharide metabolism (HP:0010968)3.95562707
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.95562707
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86910686
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.78946332
26Joint hemorrhage (HP:0005261)3.72312169
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.68146373
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66322442
29Abnormality of the common coagulation pathway (HP:0010990)3.66031825
30Epidermoid cyst (HP:0200040)3.62426425
31Abnormality of methionine metabolism (HP:0010901)3.54924612
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.53970723
33Dicarboxylic aciduria (HP:0003215)3.53970723
34Hypoalphalipoproteinemia (HP:0003233)3.51753984
35Fat malabsorption (HP:0002630)3.51123508
36Generalized aminoaciduria (HP:0002909)3.49781294
37Abnormality of pyrimidine metabolism (HP:0004353)3.40873325
38Abnormality of the intrinsic pathway (HP:0010989)3.32613749
39Hyperbilirubinemia (HP:0002904)3.30408585
40Abnormality of nucleobase metabolism (HP:0010932)3.27415800
41Gout (HP:0001997)3.24787308
42Abnormality of purine metabolism (HP:0004352)3.20687038
43Metabolic acidosis (HP:0001942)3.12722285
44Purpura (HP:0000979)3.11787018
45Delayed CNS myelination (HP:0002188)3.11328126
46Abnormality of serum amino acid levels (HP:0003112)3.06657685
47Recurrent abscess formation (HP:0002722)3.05631079
48Abnormality of complement system (HP:0005339)3.04659332
49Lethargy (HP:0001254)3.00001302
50Hypercholesterolemia (HP:0003124)2.99474867
51Cerebral edema (HP:0002181)2.96165468
52Conjugated hyperbilirubinemia (HP:0002908)2.90916551
53Reduced antithrombin III activity (HP:0001976)2.89683951
54Prolonged neonatal jaundice (HP:0006579)2.89556212
55Proximal tubulopathy (HP:0000114)2.82011467
56Vacuolated lymphocytes (HP:0001922)2.80783650
57Increased cerebral lipofuscin (HP:0011813)2.79941227
58Late onset (HP:0003584)2.79664980
59Hypoglycemic seizures (HP:0002173)2.78201345
60Dysostosis multiplex (HP:0000943)2.77991209
61Increased intramyocellular lipid droplets (HP:0012240)2.70667086
62Recurrent bacterial skin infections (HP:0005406)2.70621899
63Hepatocellular carcinoma (HP:0001402)2.69700212
64Recurrent gram-negative bacterial infections (HP:0005420)2.69232353
65Petechiae (HP:0000967)2.64518518
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64340942
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64340942
68Obstructive lung disease (HP:0006536)2.60323066
69Chronic obstructive pulmonary disease (HP:0006510)2.60323066
70Steatorrhea (HP:0002570)2.60008964
71Abnormality of macrophages (HP:0004311)2.56868030
72Vomiting (HP:0002013)2.54814936
73Abnormality of urine glucose concentration (HP:0011016)2.53833120
74Glycosuria (HP:0003076)2.53833120
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.52415088
76Glomerulonephritis (HP:0000099)2.51782017
77Hyperinsulinemic hypoglycemia (HP:0000825)2.51580845
78Hepatic necrosis (HP:0002605)2.47954360
79Skin nodule (HP:0200036)2.46278077
80Increased serum ferritin (HP:0003281)2.43420239
81Vertebral compression fractures (HP:0002953)2.42917861
82Eczematoid dermatitis (HP:0000976)2.41041587
83Type I transferrin isoform profile (HP:0003642)2.40735614
84Nausea (HP:0002018)2.40603946
85Vascular calcification (HP:0004934)2.40298119
86Elevated erythrocyte sedimentation rate (HP:0003565)2.35983445
87Progressive neurologic deterioration (HP:0002344)2.35560279
88Spastic diplegia (HP:0001264)2.34712170
89Increased purine levels (HP:0004368)2.34256003
90Hyperuricemia (HP:0002149)2.34256003
91Myoglobinuria (HP:0002913)2.32280585
92Abnormality of polysaccharide metabolism (HP:0011012)2.31696521
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31696521
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31696521
95Malnutrition (HP:0004395)2.30154442
96Cerebral palsy (HP:0100021)2.27560580
97Irritability (HP:0000737)2.27083478
98Abnormal gallbladder morphology (HP:0012437)2.27058087
99Hepatocellular necrosis (HP:0001404)2.26687134
100Neonatal onset (HP:0003623)2.25594107
101Myocardial infarction (HP:0001658)2.24122706
102Cholelithiasis (HP:0001081)2.23585634
103Acanthocytosis (HP:0001927)2.22461808
104Systemic lupus erythematosus (HP:0002725)2.21876913
105Pancreatitis (HP:0001733)2.21137564
106Amyloidosis (HP:0011034)2.21103261
107Mitochondrial inheritance (HP:0001427)2.20512379
108Abnormal mitochondria in muscle tissue (HP:0008316)2.19174761
109Mucopolysacchariduria (HP:0008155)2.18395602
110Urinary glycosaminoglycan excretion (HP:0003541)2.18395602
111Hydroxyprolinuria (HP:0003080)2.17483133
112Abnormality of proline metabolism (HP:0010907)2.17483133
113Hepatosplenomegaly (HP:0001433)2.17263976
114Renal cortical cysts (HP:0000803)2.17254575
115Mediastinal lymphadenopathy (HP:0100721)2.14011066
116Cardiovascular calcification (HP:0011915)2.13742001
117Opisthotonus (HP:0002179)2.12728025
118Alkalosis (HP:0001948)2.11696234
119Loss of speech (HP:0002371)2.11509089
120Spontaneous abortion (HP:0005268)2.11500957
121Brushfield spots (HP:0001088)2.09279045
122Abnormal cartilage morphology (HP:0002763)2.08917958
123Myositis (HP:0100614)2.07595089
124Lactic acidosis (HP:0003128)2.07411378
125Increased serum pyruvate (HP:0003542)2.06820373
126Acute encephalopathy (HP:0006846)2.05944717
127Renal Fanconi syndrome (HP:0001994)2.05249244
128Polygenic inheritance (HP:0010982)2.05076719
129Symptomatic seizures (HP:0011145)2.03193451
130Sensorimotor neuropathy (HP:0007141)2.01437065
131Axonal loss (HP:0003447)2.01414445
132Increased muscle lipid content (HP:0009058)2.01229371
133Mitral stenosis (HP:0001718)2.01061405
134Abnormality of iron homeostasis (HP:0011031)2.00869450
135Abnormality of transition element cation homeostasis (HP:0011030)2.00747527
136Cholecystitis (HP:0001082)2.00198809
137Abnormal gallbladder physiology (HP:0012438)2.00198809
138Abnormal protein glycosylation (HP:0012346)1.98642504
139Abnormal glycosylation (HP:0012345)1.98642504
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98642504
141Abnormal protein N-linked glycosylation (HP:0012347)1.98642504
142Enlarged kidneys (HP:0000105)1.98188922
143Abnormality of glycolysis (HP:0004366)1.96195221
144Abnormal enzyme/coenzyme activity (HP:0012379)1.96034118
145Hypochromic microcytic anemia (HP:0004840)1.95590473
146Rhabdomyolysis (HP:0003201)1.93999124
147Gingival bleeding (HP:0000225)1.93098273
148Poikilocytosis (HP:0004447)1.91223675
149Elevated hepatic transaminases (HP:0002910)1.90721127
150Meningitis (HP:0001287)1.87909244
151Bulbar palsy (HP:0001283)1.87762233
152Hypertensive crisis (HP:0100735)1.87356749
153Ragged-red muscle fibers (HP:0003200)1.86576132
154Acute hepatic failure (HP:0006554)1.86146717
155Abnormality of the gallbladder (HP:0005264)1.85965802
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85341139
157Acute necrotizing encephalopathy (HP:0006965)1.84109736
158Stomatitis (HP:0010280)1.83482459
159Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82214537
160Increased CSF lactate (HP:0002490)1.81699768
161Microvesicular hepatic steatosis (HP:0001414)1.78121816
162Respiratory failure (HP:0002878)1.76897802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.48491998
2ERN14.19830453
3VRK24.14942736
4SIK13.62786631
5FGFR43.45610614
6TRIB32.85364181
7INSRR2.78965556
8SMG12.61173810
9FLT32.49835218
10PKN22.48808721
11TESK12.19540308
12TAOK32.11670913
13NME21.79877975
14MST1R1.75896583
15KDR1.75720026
16WNK41.69448994
17TYK21.69061389
18MAPK111.67568670
19PDK31.54669751
20PDK41.54669751
21PIK3CG1.54034256
22ARAF1.51201952
23NEK11.45358987
24MAP2K31.42377885
25ERBB41.40340732
26MAP3K101.39725474
27SCYL21.38298894
28NEK91.38249492
29ABL21.35069425
30MAP3K111.30604977
31PTK61.27564621
32IKBKB1.22895086
33TBK11.22565049
34MAP3K31.19762643
35PINK11.19658234
36MAP4K21.17523968
37LIMK11.12438486
38MYLK1.05918729
39TAF11.03382199
40EIF2AK11.03372613
41TNK21.01958542
42IRAK41.01036294
43FRK0.99035216
44JAK20.98463676
45MAPK150.98206950
46DAPK10.95642541
47STK38L0.95378071
48DYRK1B0.94488785
49TIE10.92988217
50GRK60.91828296
51PRKAA20.90846085
52GRK70.90482360
53MAP3K10.89061956
54TTN0.86172181
55VRK10.84985136
56LATS10.82584551
57RIPK40.82100890
58MET0.81703464
59SYK0.80422121
60LRRK20.80183826
61MAP2K40.78085279
62DAPK30.77084476
63IRAK30.76969012
64MATK0.76095546
65CDK60.74487316
66EPHB10.73514665
67MAP3K70.72980904
68GRK50.72897360
69TAOK10.72450028
70CDK40.70954580
71TGFBR20.68902302
72CSNK1G30.68396163
73STK160.68143264
74FES0.67956770
75WNK30.67919426
76MAP4K10.66618177
77LMTK20.65050216
78ACVR1B0.64911410
79IRAK20.63980613
80MAPK40.63624703
81ERBB20.63113922
82RPS6KA40.62754515
83EPHA20.62722786
84JAK10.62392574
85PDK20.62101457
86MAP3K130.61866825
87MAP2K60.61198837
88LYN0.58013699
89PRKACG0.57707518
90PRKAA10.57187794
91EPHA30.56790731
92PRPF4B0.56777891
93MAPKAPK30.55938853
94BTK0.54676329
95TAOK20.54214608
96RIPK10.54070513
97PIK3CA0.53850337
98MOS0.53537473
99GSK3A0.52869162
100KIT0.51627049
101MAP2K20.50455831
102ZAP700.50253157
103CSF1R0.49603418
104PAK40.49380770
105OBSCN0.49372704
106MAP3K50.48560764
107MAPKAPK50.48035266
108MAP3K120.47056012
109RPS6KB20.46269073
110MAPK120.45636269
111CDK90.45615939
112IKBKE0.43893438
113TLK10.42990670
114PRKCZ0.41032770
115ILK0.40784171
116CSNK1A1L0.40742914
117CDK190.40261603
118MAPKAPK20.39770130
119PASK0.39729617
120DAPK20.39404909
121CSK0.37900480
122LCK0.36850903
123OXSR10.36820860
124CAMK1D0.36551035
125TXK0.36337058
126PTK20.35913933
127PDPK10.35702027
128TESK20.35557891
129HCK0.35429749
130STK40.35375581
131RPS6KA50.35090937
132RPS6KC10.34130548
133RPS6KL10.34130548
134ITK0.32823825
135PRKD20.32561033
136PRKCD0.32468652
137CAMK2G0.32448428
138HIPK20.32337508
139BLK0.32181422
140PIM20.31707162
141PRKG20.30897239
142MAP2K10.30773143
143MAP3K80.30635017
144JAK30.30411936
145MTOR0.29409957
146MAP3K140.29042004
147TGFBR10.28839111
148TEC0.28586250

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.87135280
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27113889
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98301389
4Fatty acid degradation_Homo sapiens_hsa000712.89676625
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81564613
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80949189
7Nitrogen metabolism_Homo sapiens_hsa009102.78379777
8Tryptophan metabolism_Homo sapiens_hsa003802.73063263
9Arginine biosynthesis_Homo sapiens_hsa002202.56277989
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50016687
11Propanoate metabolism_Homo sapiens_hsa006402.48780779
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37865832
13Butanoate metabolism_Homo sapiens_hsa006502.34178428
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32132914
15* Peroxisome_Homo sapiens_hsa041462.14490880
16Complement and coagulation cascades_Homo sapiens_hsa046102.13434231
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11235419
18Fatty acid metabolism_Homo sapiens_hsa012122.05764212
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97839411
20PPAR signaling pathway_Homo sapiens_hsa033201.88437175
21beta-Alanine metabolism_Homo sapiens_hsa004101.83177253
22Histidine metabolism_Homo sapiens_hsa003401.79238397
23Pyruvate metabolism_Homo sapiens_hsa006201.77471180
24Chemical carcinogenesis_Homo sapiens_hsa052041.75123761
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73674709
26Selenocompound metabolism_Homo sapiens_hsa004501.72870729
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71372500
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.69838740
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64789251
30Sulfur metabolism_Homo sapiens_hsa009201.59913900
31Caffeine metabolism_Homo sapiens_hsa002321.56190765
32Asthma_Homo sapiens_hsa053101.56025507
33Lysosome_Homo sapiens_hsa041421.55671556
34Carbon metabolism_Homo sapiens_hsa012001.55451108
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.54760203
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52717637
37Folate biosynthesis_Homo sapiens_hsa007901.52061366
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49204701
39Phenylalanine metabolism_Homo sapiens_hsa003601.47865242
40Fatty acid elongation_Homo sapiens_hsa000621.47336880
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41834543
42Proteasome_Homo sapiens_hsa030501.40962835
43Biosynthesis of amino acids_Homo sapiens_hsa012301.34807076
44Starch and sucrose metabolism_Homo sapiens_hsa005001.34565140
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.34222002
46Allograft rejection_Homo sapiens_hsa053301.33075189
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.32908033
48Staphylococcus aureus infection_Homo sapiens_hsa051501.30724666
49* Retinol metabolism_Homo sapiens_hsa008301.30233201
50Ribosome_Homo sapiens_hsa030101.29322731
51Tyrosine metabolism_Homo sapiens_hsa003501.29177346
52Bile secretion_Homo sapiens_hsa049761.29102216
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.25926793
54Fat digestion and absorption_Homo sapiens_hsa049751.20117504
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.16734450
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13910452
57Sulfur relay system_Homo sapiens_hsa041221.13792759
58Autoimmune thyroid disease_Homo sapiens_hsa053201.10926926
59Arginine and proline metabolism_Homo sapiens_hsa003301.09877462
60Graft-versus-host disease_Homo sapiens_hsa053321.07945193
61ABC transporters_Homo sapiens_hsa020101.04320897
62Pertussis_Homo sapiens_hsa051331.03768772
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00247235
64Leishmaniasis_Homo sapiens_hsa051400.99330131
65Base excision repair_Homo sapiens_hsa034100.98507944
66Glutathione metabolism_Homo sapiens_hsa004800.94583990
67Rheumatoid arthritis_Homo sapiens_hsa053230.91741814
68Lysine degradation_Homo sapiens_hsa003100.91199182
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90886331
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89805446
71One carbon pool by folate_Homo sapiens_hsa006700.87331583
72Antigen processing and presentation_Homo sapiens_hsa046120.85526736
73Vitamin digestion and absorption_Homo sapiens_hsa049770.85523353
74Type I diabetes mellitus_Homo sapiens_hsa049400.81066437
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81058704
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80501552
77Pentose phosphate pathway_Homo sapiens_hsa000300.80371232
78Steroid biosynthesis_Homo sapiens_hsa001000.79716848
79Glycerolipid metabolism_Homo sapiens_hsa005610.72040586
80Primary immunodeficiency_Homo sapiens_hsa053400.71230396
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67360400
82Tuberculosis_Homo sapiens_hsa051520.65471094
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62008250
84Vitamin B6 metabolism_Homo sapiens_hsa007500.60388162
85Osteoclast differentiation_Homo sapiens_hsa043800.59812983
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57871819
87* Metabolic pathways_Homo sapiens_hsa011000.57293256
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54821954
89Galactose metabolism_Homo sapiens_hsa000520.50169350
90DNA replication_Homo sapiens_hsa030300.47588919
91Hematopoietic cell lineage_Homo sapiens_hsa046400.47162705
92Fructose and mannose metabolism_Homo sapiens_hsa000510.46958773
93N-Glycan biosynthesis_Homo sapiens_hsa005100.46686906
94Viral myocarditis_Homo sapiens_hsa054160.46654468
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.45701794
96Herpes simplex infection_Homo sapiens_hsa051680.44780831
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43857224
98Phagosome_Homo sapiens_hsa041450.43805498
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42120943
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40087598
101Fatty acid biosynthesis_Homo sapiens_hsa000610.40081523
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39046623
103Insulin resistance_Homo sapiens_hsa049310.28408191
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.26803115
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24074874
106Parkinsons disease_Homo sapiens_hsa050120.19236161
107Oxidative phosphorylation_Homo sapiens_hsa001900.19173253
108Linoleic acid metabolism_Homo sapiens_hsa005910.15765748
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13773165
110Prion diseases_Homo sapiens_hsa050200.11105870
111Glucagon signaling pathway_Homo sapiens_hsa049220.09870855
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08941622
113AMPK signaling pathway_Homo sapiens_hsa041520.06437764
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02434716
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.01731613
116Pyrimidine metabolism_Homo sapiens_hsa002400.01722155
117Protein export_Homo sapiens_hsa030600.00064041
118Bladder cancer_Homo sapiens_hsa05219-0.1713722
119Legionellosis_Homo sapiens_hsa05134-0.1503866
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1468562
121Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1227874
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1200507
123Other glycan degradation_Homo sapiens_hsa00511-0.0966657
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0950095
125Huntingtons disease_Homo sapiens_hsa05016-0.0942739
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0814470
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0764929
128Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0639115
129Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0592414
130Alzheimers disease_Homo sapiens_hsa05010-0.0089388
131Renin-angiotensin system_Homo sapiens_hsa04614-0.0067807

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