ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mannosylation (GO:0097502)	6.11341555
2	rRNA catabolic process (GO:0016075)	5.71655287
3	ether lipid metabolic process (GO:0046485)	4.76818857
4	autophagic vacuole fusion (GO:0000046)	4.40762887
5	response to lipoprotein particle (GO:0055094)	4.27650435
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.04967492
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.04967492
8	NADH dehydrogenase complex assembly (GO:0010257)	4.04967492
9	protein complex biogenesis (GO:0070271)	4.04242841
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.00312672
11	GPI anchor metabolic process (GO:0006505)	3.95067652
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.86173488
13	organelle membrane fusion (GO:0090174)	3.84991345
14	GPI anchor biosynthetic process (GO:0006506)	3.80256742
15	positive regulation of digestive system process (GO:0060456)	3.77606854
16	adenosine metabolic process (GO:0046085)	3.76868614
17	response to pheromone (GO:0019236)	3.71481142
18	amino-acid betaine transport (GO:0015838)	3.62440979
19	carnitine transport (GO:0015879)	3.62440979
20	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.59863967
21	carnitine transmembrane transport (GO:1902603)	3.56321288
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52802585
23	positive regulation of prostaglandin secretion (GO:0032308)	3.49527074
24	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.40614372
25	glycerol ether metabolic process (GO:0006662)	3.28753791
26	regulation of hexokinase activity (GO:1903299)	3.27527545
27	regulation of glucokinase activity (GO:0033131)	3.27527545
28	respiratory chain complex IV assembly (GO:0008535)	3.26038285
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.21330229
30	cellular ketone body metabolic process (GO:0046950)	3.15006007
31	cytochrome complex assembly (GO:0017004)	3.12184095
32	labyrinthine layer development (GO:0060711)	3.09451305
33	DNA double-strand break processing (GO:0000729)	3.09400310
34	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.06018147
35	regulation of growth of symbiont in host (GO:0044126)	3.06018147
36	negative regulation of growth of symbiont in host (GO:0044130)	3.06018147
37	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.06018147
38	ether metabolic process (GO:0018904)	3.05067424
39	axoneme assembly (GO:0035082)	2.94905528
40	cellular response to antibiotic (GO:0071236)	2.94331027
41	xenobiotic catabolic process (GO:0042178)	2.87158643
42	protein polyglutamylation (GO:0018095)	2.85723388
43	C-terminal protein lipidation (GO:0006501)	2.85027320
44	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.84902453
45	quaternary ammonium group transport (GO:0015697)	2.84740619
46	phenylpropanoid metabolic process (GO:0009698)	2.83286704
47	glyoxylate metabolic process (GO:0046487)	2.82865049
48	ketone body metabolic process (GO:1902224)	2.81972217
49	urate metabolic process (GO:0046415)	2.80841716
50	organic cation transport (GO:0015695)	2.79524880
51	proteasome assembly (GO:0043248)	2.77603067
52	response to nitrosative stress (GO:0051409)	2.76184449
53	cellular response to interferon-beta (GO:0035458)	2.74940004
54	branched-chain amino acid catabolic process (GO:0009083)	2.73696591
55	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.68951491
56	indole-containing compound catabolic process (GO:0042436)	2.67562985
57	indolalkylamine catabolic process (GO:0046218)	2.67562985
58	tryptophan catabolic process (GO:0006569)	2.67562985
59	regulation of cellular amino acid metabolic process (GO:0006521)	2.66692359
60	maturation of 5.8S rRNA (GO:0000460)	2.65592320
61	nucleobase catabolic process (GO:0046113)	2.64193749
62	RNA phosphodiester bond hydrolysis (GO:0090501)	2.63276981
63	lactate metabolic process (GO:0006089)	2.61699666
64	amino acid salvage (GO:0043102)	2.61662362
65	L-methionine salvage (GO:0071267)	2.61662362
66	L-methionine biosynthetic process (GO:0071265)	2.61662362
67	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.61414081
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.60344724
69	purine deoxyribonucleotide catabolic process (GO:0009155)	2.59869320
70	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.59140141
71	indolalkylamine metabolic process (GO:0006586)	2.59001058
72	peroxisome organization (GO:0007031)	2.58488161
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.57807928
74	deoxyribonucleotide catabolic process (GO:0009264)	2.57632326
75	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.56983030
76	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.56983030
77	acrosome assembly (GO:0001675)	2.56330938
78	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.53671785
79	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	2.52865718
80	ncRNA catabolic process (GO:0034661)	2.52160195
81	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.51968144
82	regulation of prostaglandin secretion (GO:0032306)	2.51837006
83	protein import into peroxisome matrix (GO:0016558)	2.51782226
84	positive regulation of fatty acid transport (GO:2000193)	2.51088914
85	cellular biogenic amine catabolic process (GO:0042402)	2.49601512
86	amine catabolic process (GO:0009310)	2.49601512
87	DNA methylation involved in gamete generation (GO:0043046)	2.49162712
88	pyrimidine nucleobase catabolic process (GO:0006208)	2.48885668
89	S-adenosylmethionine metabolic process (GO:0046500)	2.48865279
90	C-terminal protein amino acid modification (GO:0018410)	2.48331826
91	deoxyribose phosphate catabolic process (GO:0046386)	2.47262213
92	purine-containing compound salvage (GO:0043101)	2.46401610
93	positive regulation of icosanoid secretion (GO:0032305)	2.44600465
94	angiotensin maturation (GO:0002003)	2.43040497
95	regulation of triglyceride catabolic process (GO:0010896)	2.42595782
96	response to interferon-beta (GO:0035456)	2.42081403
97	positive regulation of mRNA catabolic process (GO:0061014)	2.41694618
98	positive regulation of calcium ion import (GO:0090280)	2.41363603
99	positive regulation of respiratory burst (GO:0060267)	2.41237202
100	cellular response to toxic substance (GO:0097237)	2.40594737

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.53577859
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.03836877
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.51999190
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.38022150
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.00316340
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85608201
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.81479884
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.81076712
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76332412
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.74296804
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.59956920
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.47833015
13	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.38816484
14	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.35218655
15	CIITA_25753668_ChIP-Seq_RAJI_Human	2.32682673
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.29556162
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24200712
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.23059605
19	GBX2_23144817_ChIP-Seq_PC3_Human	2.09354196
20	FUS_26573619_Chip-Seq_HEK293_Human	2.05821745
21	GATA1_22025678_ChIP-Seq_K562_Human	1.90967221
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.89817719
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88874655
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86473256
25	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.82812909
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.82812909
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.81159335
28	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.79438663
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.79417454
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73705555
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73128844
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71031131
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.66981669
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.66238185
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58581279
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.49768172
37	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.48777218
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.46827968
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46631491
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.42285478
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.40399872
42	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.40393171
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39784324
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38975299
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38930339
46	* AR_20517297_ChIP-Seq_VCAP_Human	1.35916517
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33720345
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33071856
49	VDR_22108803_ChIP-Seq_LS180_Human	1.32772778
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29020109
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.26715344
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25480228
53	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.24053333
54	RAC3_21632823_ChIP-Seq_H3396_Human	1.20852324
55	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.20504010
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.20399468
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20374579
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17362417
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.15978283
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13715313
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13064225
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10619309
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.10619309
64	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.10171060
65	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08015048
66	GATA3_26560356_Chip-Seq_TH2_Human	1.06833838
67	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.06297408
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04572198
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04563398
70	NCOR_22424771_ChIP-Seq_293T_Human	1.04270532
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.02804178
72	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.01751386
73	P300_19829295_ChIP-Seq_ESCs_Human	1.01205665
74	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.00350918
75	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98672039
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98484276
77	EWS_26573619_Chip-Seq_HEK293_Human	0.97856421
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96796463
79	CDX2_22108803_ChIP-Seq_LS180_Human	0.96624132
80	* NANOG_19829295_ChIP-Seq_ESCs_Human	0.95122755
81	* SOX2_19829295_ChIP-Seq_ESCs_Human	0.95122755
82	GATA3_27048872_Chip-Seq_THYMUS_Human	0.94078611
83	MYB_26560356_Chip-Seq_TH2_Human	0.93790487
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92869102
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92235915
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91147067
87	CBP_21632823_ChIP-Seq_H3396_Human	0.90927089
88	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.89380130
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88139451
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88079987
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88058946
92	AR_25329375_ChIP-Seq_VCAP_Human	0.87323484
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86386242
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86286441
95	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.86229834
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.85687530
97	CEBPB_22108803_ChIP-Seq_LS180_Human	0.84569241
98	P300_27268052_Chip-Seq_Bcells_Human	0.83607772
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.82079227
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.81761993

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	6.59809432
2	MP0002837_dystrophic_cardiac_calcinosis	3.36765924
3	MP0001986_abnormal_taste_sensitivity	3.33296918
4	MP0003806_abnormal_nucleotide_metabolis	3.18274024
5	MP0000372_irregular_coat_pigmentation	3.04835473
6	MP0004043_abnormal_pH_regulation	2.68587198
7	MP0005083_abnormal_biliary_tract	2.21806411
8	MP0005646_abnormal_pituitary_gland	2.18798243
9	MP0003787_abnormal_imprinting	2.18520613
10	MP0001764_abnormal_homeostasis	2.10014628
11	MP0003656_abnormal_erythrocyte_physiolo	1.94827545
12	MP0005451_abnormal_body_composition	1.89337624
13	MP0008875_abnormal_xenobiotic_pharmacok	1.87286676
14	MP0005397_hematopoietic_system_phenotyp	1.86787891
15	MP0001545_abnormal_hematopoietic_system	1.86787891
16	MP0003724_increased_susceptibility_to	1.81457061
17	MP0002163_abnormal_gland_morphology	1.77757778
18	MP0002132_abnormal_respiratory_system	1.75768081
19	MP0005075_abnormal_melanosome_morpholog	1.71592411
20	MP0002148_abnormal_hypersensitivity_rea	1.70526802
21	MP0004484_altered_response_of	1.70264129
22	MP0006276_abnormal_autonomic_nervous	1.67707168
23	MP0002139_abnormal_hepatobiliary_system	1.66971755
24	MP0005085_abnormal_gallbladder_physiolo	1.62818053
25	MP0008058_abnormal_DNA_repair	1.61268451
26	MP0003646_muscle_fatigue	1.60052455
27	MP0002638_abnormal_pupillary_reflex	1.57534873
28	MP0005367_renal/urinary_system_phenotyp	1.54027046
29	MP0000516_abnormal_urinary_system	1.54027046
30	MP0005084_abnormal_gallbladder_morpholo	1.51185254
31	MP0005636_abnormal_mineral_homeostasis	1.51098687
32	MP0004147_increased_porphyrin_level	1.49038251
33	MP0003718_maternal_effect	1.47977621
34	MP0005464_abnormal_platelet_physiology	1.44947296
35	MP0005671_abnormal_response_to	1.43477575
36	MP0002909_abnormal_adrenal_gland	1.41561693
37	MP0004142_abnormal_muscle_tone	1.40132830
38	MP0001835_abnormal_antigen_presentation	1.39832517
39	MP0005645_abnormal_hypothalamus_physiol	1.38156460
40	MP0008995_early_reproductive_senescence	1.34516220
41	MP0009278_abnormal_bone_marrow	1.32856774
42	MP0005379_endocrine/exocrine_gland_phen	1.31516414
43	MP0002138_abnormal_hepatobiliary_system	1.28984442
44	MP0001666_abnormal_nutrient_absorption	1.22257911
45	MP0002160_abnormal_reproductive_system	1.21054228
46	MP0000639_abnormal_adrenal_gland	1.18964834
47	MP0009046_muscle_twitch	1.18956278
48	MP0005410_abnormal_fertilization	1.16743271
49	MP0005332_abnormal_amino_acid	1.15556130
50	MP0005365_abnormal_bile_salt	1.13079671
51	MP0010329_abnormal_lipoprotein_level	1.10636681
52	MP0003786_premature_aging	1.08783634
53	MP0004134_abnormal_chest_morphology	1.08756694
54	MP0003172_abnormal_lysosome_physiology	1.08244575
55	MP0005220_abnormal_exocrine_pancreas	1.07780292
56	MP0009643_abnormal_urine_homeostasis	1.05149372
57	MP0005165_increased_susceptibility_to	0.97489983
58	MP0003123_paternal_imprinting	0.97317299
59	MP0002693_abnormal_pancreas_physiology	0.96566133
60	MP0006036_abnormal_mitochondrial_physio	0.94146086
61	MP0003075_altered_response_to	0.91028573
62	MP0005389_reproductive_system_phenotype	0.88460688
63	MP0005376_homeostasis/metabolism_phenot	0.88011407
64	MP0005670_abnormal_white_adipose	0.87165586
65	MP0005330_cardiomyopathy	0.83829569
66	MP0005408_hypopigmentation	0.81462706
67	MP0010386_abnormal_urinary_bladder	0.80024776
68	MP0008872_abnormal_physiological_respon	0.79996223
69	MP0005000_abnormal_immune_tolerance	0.79523499
70	MP0000015_abnormal_ear_pigmentation	0.79119239
71	MP0001968_abnormal_touch/_nociception	0.78916885
72	MP0005266_abnormal_metabolism	0.77965240
73	MP0002118_abnormal_lipid_homeostasis	0.75933288
74	MP0001661_extended_life_span	0.72717945
75	MP0006035_abnormal_mitochondrial_morpho	0.72578910
76	MP0000569_abnormal_digit_pigmentation	0.72514249
77	MP0009785_altered_susceptibility_to	0.72193610
78	MP0008873_increased_physiological_sensi	0.70931123
79	MP0005395_other_phenotype	0.69978718
80	MP0000689_abnormal_spleen_morphology	0.69773521
81	MP0002419_abnormal_innate_immunity	0.68557935
82	MP0001873_stomach_inflammation	0.68366347
83	MP0009697_abnormal_copulation	0.68151496
84	MP0001765_abnormal_ion_homeostasis	0.68013336
85	MP0008004_abnormal_stomach_pH	0.66748876
86	MP0003698_abnormal_male_reproductive	0.66020856
87	MP0005025_abnormal_response_to	0.65063448
88	MP0005360_urolithiasis	0.64903844
89	MP0002420_abnormal_adaptive_immunity	0.64291335
90	MP0002234_abnormal_pharynx_morphology	0.63812203
91	MP0001324_abnormal_eye_pigmentation	0.63510410
92	MP0001819_abnormal_immune_cell	0.63072222
93	MP0005058_abnormal_lysosome_morphology	0.62812080
94	MP0008877_abnormal_DNA_methylation	0.62631907
95	MP0003252_abnormal_bile_duct	0.62026919
96	MP0002095_abnormal_skin_pigmentation	0.62016331
97	MP0002166_altered_tumor_susceptibility	0.61879159
98	MP0004145_abnormal_muscle_electrophysio	0.61711718
99	MP0003121_genomic_imprinting	0.61185603
100	MP0001919_abnormal_reproductive_system	0.60449690

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tongue fasciculations (HP:0001308)	4.58093706
2	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	4.40082804
3	Muscle fibrillation (HP:0010546)	3.83022716
4	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.82268059
5	Abnormal protein N-linked glycosylation (HP:0012347)	3.82268059
6	Abnormal protein glycosylation (HP:0012346)	3.82268059
7	Abnormal glycosylation (HP:0012345)	3.82268059
8	Type I transferrin isoform profile (HP:0003642)	3.54073126
9	Increased circulating renin level (HP:0000848)	3.50261752
10	Hypomagnesemia (HP:0002917)	3.36494768
11	Failure to thrive in infancy (HP:0001531)	3.15377214
12	Abnormal drinking behavior (HP:0030082)	3.06777147
13	Polydipsia (HP:0001959)	3.06777147
14	Pancreatic fibrosis (HP:0100732)	2.99865823
15	Ketoacidosis (HP:0001993)	2.82915403
16	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.79784175
17	Vacuolated lymphocytes (HP:0001922)	2.76355453
18	True hermaphroditism (HP:0010459)	2.68894737
19	Tetany (HP:0001281)	2.65470595
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.61309917
21	Reduced antithrombin III activity (HP:0001976)	2.58700052
22	Acute encephalopathy (HP:0006846)	2.58468071
23	Acute necrotizing encephalopathy (HP:0006965)	2.56978548
24	Nephronophthisis (HP:0000090)	2.56559304
25	Mitochondrial inheritance (HP:0001427)	2.54836780
26	Abnormality of magnesium homeostasis (HP:0004921)	2.53500417
27	Ketosis (HP:0001946)	2.51154885
28	Abnormality of midbrain morphology (HP:0002418)	2.50818175
29	Molar tooth sign on MRI (HP:0002419)	2.50818175
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50724412
31	Congenital stationary night blindness (HP:0007642)	2.48648079
32	Abnormality of pyrimidine metabolism (HP:0004353)	2.46069356
33	Type 2 muscle fiber atrophy (HP:0003554)	2.43174276
34	Hepatic necrosis (HP:0002605)	2.41831319
35	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.40133816
36	Short 1st metacarpal (HP:0010034)	2.40133816
37	Abnormality of the prostate (HP:0008775)	2.39325080
38	Pancreatic cysts (HP:0001737)	2.38316201
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.32650611
40	Severe visual impairment (HP:0001141)	2.32587880
41	Metaphyseal dysplasia (HP:0100255)	2.32168973
42	Hyperphosphatemia (HP:0002905)	2.30893240
43	Cerebral edema (HP:0002181)	2.29050521
44	Progressive macrocephaly (HP:0004481)	2.27119925
45	Lipid accumulation in hepatocytes (HP:0006561)	2.24251278
46	Increased CSF lactate (HP:0002490)	2.23431514
47	Hyperammonemia (HP:0001987)	2.22216638
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.20602500
49	Hepatocellular necrosis (HP:0001404)	2.20083260
50	Lethargy (HP:0001254)	2.19182398
51	Gaze-evoked nystagmus (HP:0000640)	2.16369648
52	Abnormality of the 1st metacarpal (HP:0010009)	2.13100649
53	Hypothermia (HP:0002045)	2.08995431
54	Short tibia (HP:0005736)	2.08400470
55	Polyuria (HP:0000103)	2.05993429
56	Abnormality of lateral ventricle (HP:0030047)	2.04483266
57	Increased serum pyruvate (HP:0003542)	2.04169797
58	Muscle fiber atrophy (HP:0100295)	2.03043897
59	Dry hair (HP:0011359)	2.02792658
60	Attenuation of retinal blood vessels (HP:0007843)	2.02378278
61	Exertional dyspnea (HP:0002875)	2.02044860
62	Abnormality of urine glucose concentration (HP:0011016)	2.00849512
63	Glycosuria (HP:0003076)	2.00849512
64	Confusion (HP:0001289)	1.99736640
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99192809
66	Prolonged partial thromboplastin time (HP:0003645)	1.99127426
67	Epidermoid cyst (HP:0200040)	1.98902364
68	Increased intramyocellular lipid droplets (HP:0012240)	1.98838503
69	Hyperglycinemia (HP:0002154)	1.98422843
70	Hyperphosphaturia (HP:0003109)	1.97566140
71	Increased hepatocellular lipid droplets (HP:0006565)	1.95594949
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95308949
73	Abnormality of the renal medulla (HP:0100957)	1.93108167
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92200544
75	Renal Fanconi syndrome (HP:0001994)	1.91953205
76	Stomatitis (HP:0010280)	1.90764636
77	Lower limb hyperreflexia (HP:0002395)	1.86550547
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86142816
79	Chronic hepatic failure (HP:0100626)	1.83283505
80	Increased muscle lipid content (HP:0009058)	1.83118360
81	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.82984933
82	Congenital hepatic fibrosis (HP:0002612)	1.82156211
83	Limb ataxia (HP:0002070)	1.81105636
84	Abnormal urine output (HP:0012590)	1.80874905
85	Conjugated hyperbilirubinemia (HP:0002908)	1.79957174
86	Hypoplasia of the uterus (HP:0000013)	1.79016222
87	Type I diabetes mellitus (HP:0100651)	1.78881826
88	Constricted visual fields (HP:0001133)	1.77727855
89	Abnormality of the metopic suture (HP:0005556)	1.77368764
90	Aplastic anemia (HP:0001915)	1.76986911
91	Abnormality of renin-angiotensin system (HP:0000847)	1.76427397
92	Optic disc pallor (HP:0000543)	1.72613589
93	Late onset (HP:0003584)	1.72589783
94	Abnormality of glycolysis (HP:0004366)	1.72259211
95	Metabolic acidosis (HP:0001942)	1.71878146
96	Opisthotonus (HP:0002179)	1.71729038
97	Anhidrosis (HP:0000970)	1.71531226
98	Focal motor seizures (HP:0011153)	1.71485132
99	Disproportionate short-trunk short stature (HP:0003521)	1.70699476
100	Intestinal atresia (HP:0011100)	1.69684696

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	7.26081244
2	FRK	3.81729501
3	BCKDK	2.69091853
4	MKNK1	2.66306497
5	TNK2	2.59513861
6	NME2	2.29509077
7	SCYL2	2.26726257
8	ZAK	2.25401667
9	MAPKAPK5	2.18626747
10	TAOK3	2.17644895
11	EIF2AK3	2.10811989
12	FLT3	2.04893674
13	CLK1	1.79610698
14	PKN2	1.76934371
15	PBK	1.73680226
16	PLK2	1.73246992
17	EIF2AK1	1.65932067
18	GRK1	1.57831878
19	TEC	1.57074240
20	TLK1	1.55312491
21	MAP2K3	1.45954563
22	BLK	1.40464844
23	RPS6KA5	1.39925842
24	ADRBK2	1.32561484
25	ITK	1.31474550
26	MAP3K3	1.31443147
27	BMPR1B	1.27049195
28	MAP3K6	1.20284100
29	PIM2	1.17901207
30	CDK8	1.13635930
31	TXK	1.10181737
32	MAP3K10	1.09199732
33	PRKCI	1.06763675
34	VRK1	1.04252593
35	PAK3	1.01919340
36	MAP2K6	1.01416774
37	MST4	0.97014073
38	PHKG2	0.95174329
39	PHKG1	0.95174329
40	MAP3K5	0.92089246
41	TRIM28	0.91740987
42	ARAF	0.90696661
43	OXSR1	0.90471382
44	TBK1	0.89147990
45	IKBKE	0.84825966
46	VRK2	0.84023593
47	DAPK2	0.84017229
48	FES	0.83540033
49	FER	0.82806627
50	PIK3CG	0.82119259
51	BTK	0.81986252
52	SYK	0.80741218
53	MAP3K12	0.77833180
54	INSRR	0.76542186
55	IKBKB	0.75090017
56	MAP4K1	0.72173494
57	PLK4	0.71804707
58	PDK2	0.70607320
59	KIT	0.70170557
60	LYN	0.69574439
61	ADRBK1	0.64922819
62	FGFR2	0.63221292
63	PRKCQ	0.60797487
64	MAP3K11	0.60362565
65	PRKCE	0.59128303
66	ZAP70	0.58693747
67	MAP2K4	0.58193064
68	RPS6KA4	0.57035424
69	CDK3	0.55679838
70	STK16	0.55617790
71	MARK1	0.52991464
72	PRKCG	0.51017924
73	NEK1	0.50455925
74	NUAK1	0.50292691
75	ABL1	0.49541840
76	ABL2	0.45142297
77	MAPK11	0.44367243
78	TGFBR1	0.43957193
79	STK38	0.43117467
80	PASK	0.42490099
81	TAF1	0.41578337
82	CDK6	0.41353522
83	TAOK1	0.38660818
84	DAPK1	0.38000103
85	NEK6	0.37969753
86	MAP2K7	0.37688747
87	IRAK3	0.37666806
88	PRKACA	0.36640513
89	SGK3	0.36486229
90	MAPK13	0.34234320
91	TIE1	0.33115119
92	BMPR2	0.32908277
93	FGFR3	0.32673635
94	PRKCB	0.32309359
95	HCK	0.31827336
96	KDR	0.31737912
97	ICK	0.31108683
98	YES1	0.29448022
99	SGK2	0.28803308
100	PRKAA1	0.28670999

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78943919
2	Proteasome_Homo sapiens_hsa03050	2.53674679
3	Asthma_Homo sapiens_hsa05310	2.40390686
4	Sulfur metabolism_Homo sapiens_hsa00920	2.33072155
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26261969
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18566949
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18197929
8	* Peroxisome_Homo sapiens_hsa04146	2.17667083
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16638096
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11447427
11	Fatty acid elongation_Homo sapiens_hsa00062	2.09782092
12	Butanoate metabolism_Homo sapiens_hsa00650	2.08108530
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.07046308
14	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.06249228
15	* Retinol metabolism_Homo sapiens_hsa00830	2.05604722
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.95095065
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.94564241
18	Protein export_Homo sapiens_hsa03060	1.88835223
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.81502708
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76244422
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76199504
22	RNA degradation_Homo sapiens_hsa03018	1.71649035
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70551690
24	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.67728241
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.66509443
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.61122964
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.53641597
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.51025013
29	Parkinsons disease_Homo sapiens_hsa05012	1.48003350
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.44025433
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.39314191
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.34589330
33	Glutathione metabolism_Homo sapiens_hsa00480	1.33038477
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31367662
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.27640541
36	RNA polymerase_Homo sapiens_hsa03020	1.27502712
37	Caffeine metabolism_Homo sapiens_hsa00232	1.25949492
38	Allograft rejection_Homo sapiens_hsa05330	1.24795887
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.22466179
40	Base excision repair_Homo sapiens_hsa03410	1.20148182
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.19883351
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19586901
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.16556416
44	Propanoate metabolism_Homo sapiens_hsa00640	1.15776122
45	Phototransduction_Homo sapiens_hsa04744	1.07123442
46	One carbon pool by folate_Homo sapiens_hsa00670	1.06775089
47	Other glycan degradation_Homo sapiens_hsa00511	1.04786522
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01547717
49	Regulation of autophagy_Homo sapiens_hsa04140	0.98274773
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.97846979
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95677164
52	Fatty acid degradation_Homo sapiens_hsa00071	0.94207981
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93380354
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89057912
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88682459
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.88018137
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87215804
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86896885
59	Homologous recombination_Homo sapiens_hsa03440	0.86755256
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.86261176
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.84765560
62	DNA replication_Homo sapiens_hsa03030	0.83924832
63	Lysosome_Homo sapiens_hsa04142	0.81280079
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81096153
65	* Metabolic pathways_Homo sapiens_hsa01100	0.80036141
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76975023
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76463176
68	Basal transcription factors_Homo sapiens_hsa03022	0.73910230
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73874026
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73438190
71	Purine metabolism_Homo sapiens_hsa00230	0.70993098
72	Huntingtons disease_Homo sapiens_hsa05016	0.70310210
73	Alzheimers disease_Homo sapiens_hsa05010	0.70304576
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65954505
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62304419
76	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61977792
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61730351
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.61436438
79	RNA transport_Homo sapiens_hsa03013	0.60565492
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60281502
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.60207825
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58617053
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57283431
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.55079384
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54081694
86	Nicotine addiction_Homo sapiens_hsa05033	0.50885034
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50662243
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49563970
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.45411330
90	Olfactory transduction_Homo sapiens_hsa04740	0.44588664
91	ABC transporters_Homo sapiens_hsa02010	0.42454392
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41215885
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39781107
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39691989
95	Mineral absorption_Homo sapiens_hsa04978	0.39551922
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37892131
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.35471222
98	Mismatch repair_Homo sapiens_hsa03430	0.33481008
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30059141
100	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.28704901

DHRS4L1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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