DHRS4L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)3.69133067
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.37081634
3L-phenylalanine metabolic process (GO:0006558)3.37081634
4glyoxylate metabolic process (GO:0046487)3.33298152
5positive regulation of triglyceride lipase activity (GO:0061365)3.29642390
6positive regulation of lipoprotein lipase activity (GO:0051006)3.29642390
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26779665
8purine nucleotide salvage (GO:0032261)3.23662003
9L-phenylalanine catabolic process (GO:0006559)3.17496012
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17496012
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09183961
12complement activation, alternative pathway (GO:0006957)3.06025491
13neutrophil activation involved in immune response (GO:0002283)3.04803735
14glycolipid catabolic process (GO:0019377)3.03762933
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02718954
16response to peptidoglycan (GO:0032494)2.94732158
17glycosphingolipid catabolic process (GO:0046479)2.93842197
18xenobiotic catabolic process (GO:0042178)2.93164123
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92261447
20regulation of cholesterol esterification (GO:0010872)2.91914184
21negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.88782117
22epoxygenase P450 pathway (GO:0019373)2.87872410
23fat-soluble vitamin biosynthetic process (GO:0042362)2.84979327
24nitrogen cycle metabolic process (GO:0071941)2.81784066
25negative regulation of myeloid cell apoptotic process (GO:0033033)2.81063188
26positive regulation of antigen processing and presentation (GO:0002579)2.79959987
27positive regulation of fatty acid biosynthetic process (GO:0045723)2.77693044
28B cell mediated immunity (GO:0019724)2.76056158
29cellular response to arsenic-containing substance (GO:0071243)2.73517839
30aromatic amino acid family catabolic process (GO:0009074)2.72401623
31nucleotide salvage (GO:0043173)2.71553468
32negative regulation of interleukin-12 production (GO:0032695)2.71490735
33purine deoxyribonucleotide catabolic process (GO:0009155)2.70031783
34ceramide catabolic process (GO:0046514)2.63788807
35regulation of antigen processing and presentation (GO:0002577)2.61207962
36urea metabolic process (GO:0019627)2.60630329
37urate metabolic process (GO:0046415)2.57910739
38antigen processing and presentation of endogenous antigen (GO:0019883)2.57208807
39NADH metabolic process (GO:0006734)2.56124513
40cellular response to zinc ion (GO:0071294)2.49017644
41angiotensin maturation (GO:0002003)2.48455080
42detection of bacterium (GO:0016045)2.48212018
43regulation of triglyceride catabolic process (GO:0010896)2.47711710
44mature B cell differentiation involved in immune response (GO:0002313)2.47698808
45pinocytosis (GO:0006907)2.45093894
46urea cycle (GO:0000050)2.44945994
47regulation of fibrinolysis (GO:0051917)2.44719611
48NIK/NF-kappaB signaling (GO:0038061)2.44568210
49amino sugar catabolic process (GO:0046348)2.44445053
50negative regulation of fibrinolysis (GO:0051918)2.43133843
51membrane lipid catabolic process (GO:0046466)2.41208607
52regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40688377
53response to interferon-beta (GO:0035456)2.40651468
54sulfur amino acid catabolic process (GO:0000098)2.40385523
55positive regulation of gamma-delta T cell activation (GO:0046645)2.38441888
56response to thyroid hormone (GO:0097066)2.37883797
57ethanol oxidation (GO:0006069)2.37527621
58tryptophan metabolic process (GO:0006568)2.37376773
59regulation of superoxide anion generation (GO:0032928)2.34329935
60detection of other organism (GO:0098543)2.33513536
61drug catabolic process (GO:0042737)2.32363662
62indole-containing compound catabolic process (GO:0042436)2.32317721
63indolalkylamine catabolic process (GO:0046218)2.32317721
64tryptophan catabolic process (GO:0006569)2.32317721
65sphingolipid catabolic process (GO:0030149)2.31825747
66acute-phase response (GO:0006953)2.31441621
67deoxyribonucleotide catabolic process (GO:0009264)2.31364032
68regulation of T-helper 1 cell differentiation (GO:0045625)2.29411669
69glycoside metabolic process (GO:0016137)2.29044718
70oligosaccharide catabolic process (GO:0009313)2.28728302
71positive regulation of B cell differentiation (GO:0045579)2.28189831
72exogenous drug catabolic process (GO:0042738)2.26529447
73negative regulation of granulocyte differentiation (GO:0030853)2.25266236
74oxaloacetate metabolic process (GO:0006107)2.24637814
75hydrogen peroxide biosynthetic process (GO:0050665)2.24596214
76N-acetylneuraminate metabolic process (GO:0006054)2.24082209
77drug metabolic process (GO:0017144)2.23213960
78phospholipid efflux (GO:0033700)2.23213838
79branched-chain amino acid catabolic process (GO:0009083)2.23048874
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.22497480
81reactive oxygen species biosynthetic process (GO:1903409)2.20620832
82branched-chain amino acid metabolic process (GO:0009081)2.19812694
83fatty acid catabolic process (GO:0009062)2.19657096
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.19219511
85bile acid biosynthetic process (GO:0006699)2.18276660
86cellular metabolic compound salvage (GO:0043094)2.17784589
87negative regulation of nitric oxide biosynthetic process (GO:0045019)2.17752913
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.17258895
89regulation of protein activation cascade (GO:2000257)2.16972385
90fructose metabolic process (GO:0006000)2.16939767
91deoxyribose phosphate catabolic process (GO:0046386)2.16604043
92GDP-mannose metabolic process (GO:0019673)2.15019789
93purine-containing compound salvage (GO:0043101)2.15003665
94cellular response to thyroid hormone stimulus (GO:0097067)2.13943342
95daunorubicin metabolic process (GO:0044597)2.13630721
96polyketide metabolic process (GO:0030638)2.13630721
97doxorubicin metabolic process (GO:0044598)2.13630721
98omega-hydroxylase P450 pathway (GO:0097267)2.13567022
99fibrinolysis (GO:0042730)2.12229138
100interferon-gamma-mediated signaling pathway (GO:0060333)2.12138159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.77228963
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.13314130
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04179900
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88994229
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64173612
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.50168677
7VDR_21846776_ChIP-Seq_THP-1_Human2.36156915
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35682337
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34468718
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.28957284
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14506622
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.11221516
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01830873
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99391107
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98862329
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97105058
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95211607
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94289265
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90876432
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88873980
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83522410
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78268092
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77922152
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76257628
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72924212
26LXR_22292898_ChIP-Seq_THP-1_Human1.71376378
27SPI1_23547873_ChIP-Seq_NB4_Human1.70807618
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68026159
29BCL6_27268052_Chip-Seq_Bcells_Human1.67146259
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65641388
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65081261
32VDR_24763502_ChIP-Seq_THP-1_Human1.63658183
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.61854608
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.61465587
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57388164
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.52918077
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52015481
38BCOR_27268052_Chip-Seq_Bcells_Human1.50339807
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49445842
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49211146
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49157557
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47824823
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47328378
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46310480
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42880234
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40190225
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39923741
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38198241
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38035004
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37244758
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36600663
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36105350
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.35443354
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33206615
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32589550
56* UTX_26944678_Chip-Seq_JUKART_Human1.31941452
57CTCF_26484167_Chip-Seq_Bcells_Mouse1.30163454
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28816912
59MYC_22102868_ChIP-Seq_BL_Human1.28682779
60P68_20966046_ChIP-Seq_HELA_Human1.27950244
61MAF_26560356_Chip-Seq_TH1_Human1.26959311
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26489615
63STAT1_20625510_ChIP-Seq_HELA_Human1.25814437
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.24574364
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23934819
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.23343789
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22549217
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.21757143
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21744183
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.20211769
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19350487
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19197973
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18093873
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17431078
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17356203
76* MAF_26560356_Chip-Seq_TH2_Human1.14303173
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12736116
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12521109
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.11687596
80ZNF263_19887448_ChIP-Seq_K562_Human1.11317653
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11014503
82TFEB_21752829_ChIP-Seq_HELA_Human1.10162775
83SPI1_23127762_ChIP-Seq_K562_Human1.09925081
84MYB_26560356_Chip-Seq_TH2_Human1.09150274
85SPI1_20517297_ChIP-Seq_HL60_Human1.08194224
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08172737
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06445942
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06155740
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.05613139
90E2F1_20622854_ChIP-Seq_HELA_Human1.05354862
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05307797
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04922157
93P300_27268052_Chip-Seq_Bcells_Human1.04425450
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03929802
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03219341
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02846003
97* SA1_27219007_Chip-Seq_Bcells_Human1.01791010
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00686397
99GABP_19822575_ChIP-Seq_HepG2_Human0.99479275
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99408237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.74054875
2MP0003806_abnormal_nucleotide_metabolis4.51155827
3MP0005058_abnormal_lysosome_morphology3.45593957
4MP0009840_abnormal_foam_cell3.44020860
5MP0005365_abnormal_bile_salt2.94756723
6MP0005360_urolithiasis2.90401369
7MP0001835_abnormal_antigen_presentation2.67688979
8MP0002148_abnormal_hypersensitivity_rea2.58663236
9MP0009785_altered_susceptibility_to2.44487404
10MP0003436_decreased_susceptibility_to2.44211784
11MP0003191_abnormal_cellular_cholesterol2.32606196
12MP0003172_abnormal_lysosome_physiology2.19933110
13MP0003195_calcinosis2.15601392
14MP0005025_abnormal_response_to2.11732501
15MP0003303_peritoneal_inflammation2.08023260
16MP0008875_abnormal_xenobiotic_pharmacok2.06885769
17MP0005000_abnormal_immune_tolerance2.06648098
18MP0002419_abnormal_innate_immunity2.06217998
19MP0005085_abnormal_gallbladder_physiolo2.05724104
20MP0006082_CNS_inflammation2.00436909
21MP0001764_abnormal_homeostasis2.00039930
22MP0002138_abnormal_hepatobiliary_system1.96560391
23MP0003724_increased_susceptibility_to1.91457440
24MP0005671_abnormal_response_to1.90309401
25MP0005464_abnormal_platelet_physiology1.90236328
26MP0001790_abnormal_immune_system1.88556352
27MP0005387_immune_system_phenotype1.88556352
28MP0009333_abnormal_splenocyte_physiolog1.74060050
29MP0001800_abnormal_humoral_immune1.70589687
30MP0006036_abnormal_mitochondrial_physio1.70566195
31MP0009764_decreased_sensitivity_to1.68455533
32MP0003075_altered_response_to1.68234733
33MP0000685_abnormal_immune_system1.66632821
34MP0002723_abnormal_immune_serum1.66158670
35MP0001666_abnormal_nutrient_absorption1.66101800
36MP0002452_abnormal_antigen_presenting1.65348914
37MP0008469_abnormal_protein_level1.63019468
38MP0003186_abnormal_redox_activity1.60263014
39MP0005451_abnormal_body_composition1.56487414
40MP0010155_abnormal_intestine_physiology1.53268831
41MP0001845_abnormal_inflammatory_respons1.50903123
42MP0000604_amyloidosis1.50334679
43MP0002420_abnormal_adaptive_immunity1.48503161
44MP0001819_abnormal_immune_cell1.47009318
45MP0002837_dystrophic_cardiac_calcinosis1.46552417
46MP0002132_abnormal_respiratory_system1.44243824
47MP0009278_abnormal_bone_marrow1.44010537
48MP0005332_abnormal_amino_acid1.42370483
49MP0009643_abnormal_urine_homeostasis1.38865971
50MP0000343_altered_response_to1.38518050
51MP0005319_abnormal_enzyme/_coenzyme1.32605771
52MP0005397_hematopoietic_system_phenotyp1.29594896
53MP0001545_abnormal_hematopoietic_system1.29594896
54MP0001533_abnormal_skeleton_physiology1.29208383
55MP0010329_abnormal_lipoprotein_level1.25294602
56MP0009697_abnormal_copulation1.20688221
57MP0000716_abnormal_immune_system1.13936018
58MP0005166_decreased_susceptibility_to1.13297991
59MP0003252_abnormal_bile_duct1.13263796
60MP0001853_heart_inflammation1.12663348
61MP0003183_abnormal_peptide_metabolism1.12474469
62MP0000609_abnormal_liver_physiology1.11781065
63MP0002405_respiratory_system_inflammati1.11363465
64MP0005584_abnormal_enzyme/coenzyme_acti1.08813117
65MP0002118_abnormal_lipid_homeostasis1.05044690
66MP0003763_abnormal_thymus_physiology1.04814271
67MP0000689_abnormal_spleen_morphology1.02966187
68MP0004019_abnormal_vitamin_homeostasis1.01818000
69MP0003656_abnormal_erythrocyte_physiolo1.01518468
70MP0005636_abnormal_mineral_homeostasis0.98643546
71MP0003646_muscle_fatigue0.98425013
72MP0002398_abnormal_bone_marrow0.97846918
73MP0002429_abnormal_blood_cell0.97755575
74MP0005670_abnormal_white_adipose0.95921177
75MP0005167_abnormal_blood-brain_barrier0.95342915
76MP0000858_altered_metastatic_potential0.94242710
77MP0004510_myositis0.93251486
78MP0003868_abnormal_feces_composition0.89997908
79MP0009763_increased_sensitivity_to0.88594386
80MP0005535_abnormal_body_temperature0.88118154
81MP0003300_gastrointestinal_ulcer0.87898889
82MP0004947_skin_inflammation0.85455613
83MP0002722_abnormal_immune_system0.84167519
84MP0005266_abnormal_metabolism0.82930022
85MP0005376_homeostasis/metabolism_phenot0.82789660
86MP0000490_abnormal_crypts_of0.82246531
87MP0005165_increased_susceptibility_to0.77969386
88MP0000465_gastrointestinal_hemorrhage0.77873982
89MP0005083_abnormal_biliary_tract0.77277957
90MP0008004_abnormal_stomach_pH0.75832818
91MP0000598_abnormal_liver_morphology0.74572564
92MP0009642_abnormal_blood_homeostasis0.74451502
93MP0001663_abnormal_digestive_system0.73921194
94MP0006035_abnormal_mitochondrial_morpho0.70345439
95MP0003866_abnormal_defecation0.69660527
96MP0001661_extended_life_span0.69583992
97MP0002136_abnormal_kidney_physiology0.69387201
98MP0005310_abnormal_salivary_gland0.66944444
99MP0001873_stomach_inflammation0.66180953
100MP0001756_abnormal_urination0.65560504

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.89546401
2Abnormality of liposaccharide metabolism (HP:0010968)4.42694417
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.42694417
4Abnormality of glycolipid metabolism (HP:0010969)4.42694417
5Complement deficiency (HP:0004431)3.53329966
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.40120770
7Recurrent abscess formation (HP:0002722)3.13585002
8Increased cerebral lipofuscin (HP:0011813)3.11101486
9Vacuolated lymphocytes (HP:0001922)3.08563301
10Purpura (HP:0000979)3.06242902
11Dysostosis multiplex (HP:0000943)3.01037991
12Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99169824
13Glomerulonephritis (HP:0000099)2.93535226
14Recurrent gram-negative bacterial infections (HP:0005420)2.92117969
15Elevated erythrocyte sedimentation rate (HP:0003565)2.87740261
16Deep venous thrombosis (HP:0002625)2.86086882
17Increased neuronal autofluorescent lipopigment (HP:0002074)2.85391363
18Abnormality of complement system (HP:0005339)2.80939344
19Increased muscle lipid content (HP:0009058)2.76507671
20Hyperammonemia (HP:0001987)2.76000392
21Petechiae (HP:0000967)2.74870651
22Abnormality of macrophages (HP:0004311)2.73901851
23Rhabdomyolysis (HP:0003201)2.73391683
24Dicarboxylic aciduria (HP:0003215)2.72920921
25Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72920921
26Increased serum ferritin (HP:0003281)2.72688731
27Reduced antithrombin III activity (HP:0001976)2.71585318
28Abnormality of polysaccharide metabolism (HP:0011012)2.67280476
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67280476
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67280476
31Recurrent bacterial skin infections (HP:0005406)2.66756455
32Increased intramyocellular lipid droplets (HP:0012240)2.65607148
33Prolonged neonatal jaundice (HP:0006579)2.63750715
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61328830
35Chronic obstructive pulmonary disease (HP:0006510)2.59683647
36Obstructive lung disease (HP:0006536)2.59683647
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59011916
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59011916
39Loss of speech (HP:0002371)2.56326977
40Progressive neurologic deterioration (HP:0002344)2.54398395
41Generalized aminoaciduria (HP:0002909)2.52602584
42Abnormality of fatty-acid metabolism (HP:0004359)2.52322785
43Myositis (HP:0100614)2.48152115
44Stomatitis (HP:0010280)2.47775966
45Prolonged partial thromboplastin time (HP:0003645)2.43407939
46Urinary glycosaminoglycan excretion (HP:0003541)2.43127610
47Mucopolysacchariduria (HP:0008155)2.43127610
48Xanthomatosis (HP:0000991)2.40619505
49Eczematoid dermatitis (HP:0000976)2.38967482
50Mediastinal lymphadenopathy (HP:0100721)2.29779144
51Hepatic necrosis (HP:0002605)2.29194350
52Abnormality of iron homeostasis (HP:0011031)2.28800297
53Type I transferrin isoform profile (HP:0003642)2.27811525
54Ragged-red muscle fibers (HP:0003200)2.21698161
55Autoimmune thrombocytopenia (HP:0001973)2.21023903
56Hepatocellular necrosis (HP:0001404)2.18753095
57Meningitis (HP:0001287)2.18276662
58Joint hemorrhage (HP:0005261)2.18249747
59Mitochondrial inheritance (HP:0001427)2.15074329
60Abnormal mitochondria in muscle tissue (HP:0008316)2.13572415
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12259928
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10802180
63Abnormality of transition element cation homeostasis (HP:0011030)2.10407663
64Amyloidosis (HP:0011034)2.08330531
65Hypobetalipoproteinemia (HP:0003563)2.07925765
66Ketosis (HP:0001946)2.07494153
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04153374
68Cerebral palsy (HP:0100021)2.03813546
69Abnormal protein glycosylation (HP:0012346)1.99158229
70Abnormal glycosylation (HP:0012345)1.99158229
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99158229
72Abnormal protein N-linked glycosylation (HP:0012347)1.99158229
73Acute encephalopathy (HP:0006846)1.99023364
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98992379
75Gingival bleeding (HP:0000225)1.98464179
76Abnormality of pyrimidine metabolism (HP:0004353)1.97239681
77Hepatosplenomegaly (HP:0001433)1.97171070
78Lethargy (HP:0001254)1.96088687
79Lactic acidosis (HP:0003128)1.95903808
80Orchitis (HP:0100796)1.94484468
81Opisthotonus (HP:0002179)1.94044048
823-Methylglutaconic aciduria (HP:0003535)1.92220617
83Cerebral edema (HP:0002181)1.85649260
84Axonal loss (HP:0003447)1.85569056
85Increased CSF lactate (HP:0002490)1.85084552
86Myoglobinuria (HP:0002913)1.84440049
87Urticaria (HP:0001025)1.84062927
88Acute necrotizing encephalopathy (HP:0006965)1.83637458
89Nausea (HP:0002018)1.82976654
90Inflammation of the large intestine (HP:0002037)1.82726104
91Agammaglobulinemia (HP:0004432)1.80290011
92Gastrointestinal inflammation (HP:0004386)1.80142725
93Recurrent fungal infections (HP:0002841)1.79954530
94Abnormality of B cell number (HP:0010975)1.79572377
95Panhypogammaglobulinemia (HP:0003139)1.79537644
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77832641
97Retinal atrophy (HP:0001105)1.77528073
98Sensorimotor neuropathy (HP:0007141)1.77332243
99Nephritis (HP:0000123)1.77245804
100Renal Fanconi syndrome (HP:0001994)1.76350338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.27645807
2BCKDK3.29767725
3ERN13.05630034
4MAP3K112.90496694
5TAOK32.80835849
6MAP4K22.68453991
7TESK22.49093944
8MAP4K12.42448605
9PIM22.35049096
10TBK12.26617785
11IRAK32.19979473
12TESK12.01747240
13VRK21.90763123
14MAP2K31.87377327
15SCYL21.79931500
16CSF1R1.79812116
17TYK21.75262975
18KDR1.73154940
19MAP3K141.63629171
20BLK1.62836724
21GRK61.56676250
22ABL21.54217088
23KIT1.47403332
24IKBKB1.46822527
25ARAF1.41503630
26TNK21.36589694
27BTK1.35343638
28SYK1.34966927
29JAK31.33163595
30IKBKE1.31323834
31STK161.31300370
32MAP3K31.30530529
33TAOK21.24565950
34GRK71.24005450
35RIPK41.22978987
36ZAP701.12869756
37FES1.08263600
38TXK1.07470857
39TGFBR21.01375495
40TAOK11.00914531
41TLK11.00141051
42LYN0.97292018
43LIMK10.96448188
44ITK0.96055979
45IRAK40.95523251
46MATK0.95254379
47ZAK0.87645912
48MAP2K60.87302493
49MAPKAPK30.86629062
50MAP2K20.84984830
51TEC0.84947691
52MAP3K50.82954888
53CSK0.82625728
54CDK190.78445688
55OBSCN0.77249755
56MAP3K10.73735470
57PINK10.71384331
58LCK0.69372863
59PRKCQ0.68740896
60VRK10.68570829
61LRRK20.68026219
62DAPK10.67079706
63MAP3K130.66374789
64RPS6KA50.65020479
65CAMKK20.60940175
66DYRK1B0.57240159
67DAPK30.54870338
68PDPK10.54844738
69HCK0.53925379
70PIM10.52758862
71ADRBK20.52679309
72PRKG20.51459938
73CCNB10.50410015
74PIK3CG0.48738532
75PDK20.47764118
76SIK10.44576951
77MAPK110.44353321
78PDK10.43339516
79MOS0.42796246
80PRKCD0.42449053
81TIE10.41604361
82FLT30.41311393
83MAP3K120.39631623
84MAP3K80.37026296
85MAPK70.36168232
86SIK30.35900412
87MAPK120.34586826
88FGR0.33872919
89IRAK20.33505941
90RPS6KC10.33373547
91RPS6KL10.33373547
92PBK0.31970213
93TRIB30.30484216
94GRK50.29972165
95MAPK40.29866264
96CSNK2A10.29295817
97DDR20.28531357
98MARK30.28457076
99CAMK2G0.27809385
100MAP3K100.27393968

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.73788676
2Staphylococcus aureus infection_Homo sapiens_hsa051502.63114313
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.21006727
4Asthma_Homo sapiens_hsa053102.10507989
5Peroxisome_Homo sapiens_hsa041462.09939631
6Sulfur metabolism_Homo sapiens_hsa009201.93734269
7Allograft rejection_Homo sapiens_hsa053301.90244327
8Complement and coagulation cascades_Homo sapiens_hsa046101.89758750
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.81850316
10Lysosome_Homo sapiens_hsa041421.81040623
11* Retinol metabolism_Homo sapiens_hsa008301.78914656
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.76685411
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73902094
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69462526
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.69068066
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67969663
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67614388
18Graft-versus-host disease_Homo sapiens_hsa053321.65530612
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65114580
20Chemical carcinogenesis_Homo sapiens_hsa052041.64713843
21Caffeine metabolism_Homo sapiens_hsa002321.64656092
22Autoimmune thyroid disease_Homo sapiens_hsa053201.63354668
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59703401
24Fatty acid degradation_Homo sapiens_hsa000711.57235338
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55383802
26Sulfur relay system_Homo sapiens_hsa041221.52692938
27Type I diabetes mellitus_Homo sapiens_hsa049401.49892699
28Rheumatoid arthritis_Homo sapiens_hsa053231.46631581
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41916545
30Phenylalanine metabolism_Homo sapiens_hsa003601.38590959
31Tryptophan metabolism_Homo sapiens_hsa003801.35232214
32Pentose phosphate pathway_Homo sapiens_hsa000301.34404227
33Leishmaniasis_Homo sapiens_hsa051401.34240054
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.33495045
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30195843
36Oxidative phosphorylation_Homo sapiens_hsa001901.29817357
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28516528
38Glutathione metabolism_Homo sapiens_hsa004801.23924590
39Arginine biosynthesis_Homo sapiens_hsa002201.21083201
40Fatty acid elongation_Homo sapiens_hsa000621.20455904
41Primary immunodeficiency_Homo sapiens_hsa053401.19606371
42Antigen processing and presentation_Homo sapiens_hsa046121.19125829
43Pertussis_Homo sapiens_hsa051331.18381896
44Carbon metabolism_Homo sapiens_hsa012001.13810799
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13141752
46Fat digestion and absorption_Homo sapiens_hsa049751.12215148
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.11978748
48Proteasome_Homo sapiens_hsa030501.11171269
49Systemic lupus erythematosus_Homo sapiens_hsa053221.10384960
50Galactose metabolism_Homo sapiens_hsa000521.07990240
51Fructose and mannose metabolism_Homo sapiens_hsa000511.07436780
52Arachidonic acid metabolism_Homo sapiens_hsa005901.06859126
53Tyrosine metabolism_Homo sapiens_hsa003501.03761610
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03271317
55PPAR signaling pathway_Homo sapiens_hsa033201.03241164
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00218226
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98885317
58Starch and sucrose metabolism_Homo sapiens_hsa005000.98841028
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98767191
60Butanoate metabolism_Homo sapiens_hsa006500.96205533
61Tuberculosis_Homo sapiens_hsa051520.96081421
62Biosynthesis of amino acids_Homo sapiens_hsa012300.94858791
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94493024
64Osteoclast differentiation_Homo sapiens_hsa043800.90264490
65Parkinsons disease_Homo sapiens_hsa050120.89623172
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.88709571
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82070826
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81414891
69Ribosome_Homo sapiens_hsa030100.81358252
70Pyruvate metabolism_Homo sapiens_hsa006200.81239636
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76849976
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76606696
73Collecting duct acid secretion_Homo sapiens_hsa049660.74130812
74Hematopoietic cell lineage_Homo sapiens_hsa046400.74070152
75Fatty acid metabolism_Homo sapiens_hsa012120.73816498
76Histidine metabolism_Homo sapiens_hsa003400.73727122
77Arginine and proline metabolism_Homo sapiens_hsa003300.71689592
78Vitamin digestion and absorption_Homo sapiens_hsa049770.71026574
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70920557
80Viral myocarditis_Homo sapiens_hsa054160.70625123
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.69713364
82Phagosome_Homo sapiens_hsa041450.68265951
83Renin-angiotensin system_Homo sapiens_hsa046140.68197883
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67993825
85* Metabolic pathways_Homo sapiens_hsa011000.65469200
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64809047
87Pyrimidine metabolism_Homo sapiens_hsa002400.62975822
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62864236
89Linoleic acid metabolism_Homo sapiens_hsa005910.62576943
90Legionellosis_Homo sapiens_hsa051340.61602883
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58672157
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56551782
93Mineral absorption_Homo sapiens_hsa049780.55261497
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55105449
95Base excision repair_Homo sapiens_hsa034100.54567593
96Herpes simplex infection_Homo sapiens_hsa051680.53325751
97Glycerolipid metabolism_Homo sapiens_hsa005610.47608686
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.47525532
99beta-Alanine metabolism_Homo sapiens_hsa004100.47217148
100Propanoate metabolism_Homo sapiens_hsa006400.47211089

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