DHRS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.73408736
2long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.05455447
3fatty-acyl-CoA biosynthetic process (GO:0046949)4.80063838
4thioester biosynthetic process (GO:0035384)4.52468106
5acyl-CoA biosynthetic process (GO:0071616)4.52468106
6long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.50486009
7fatty-acyl-CoA metabolic process (GO:0035337)4.44861851
8very long-chain fatty acid metabolic process (GO:0000038)4.02352051
9long-chain fatty acid biosynthetic process (GO:0042759)3.87867198
10axon ensheathment in central nervous system (GO:0032291)3.82861311
11central nervous system myelination (GO:0022010)3.82861311
12alpha-linolenic acid metabolic process (GO:0036109)3.79105042
13regulation of activation of Janus kinase activity (GO:0010533)3.56654435
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.54948170
15L-phenylalanine catabolic process (GO:0006559)3.54948170
16regulation of memory T cell differentiation (GO:0043380)3.51929930
17cholesterol biosynthetic process (GO:0006695)3.50473749
18low-density lipoprotein particle remodeling (GO:0034374)3.38001200
19positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34031524
20acyl-CoA metabolic process (GO:0006637)3.33264253
21thioester metabolic process (GO:0035383)3.33264253
22response to methylmercury (GO:0051597)3.21606168
23cytidine metabolic process (GO:0046087)3.21054797
24cytidine catabolic process (GO:0006216)3.21054797
25cytidine deamination (GO:0009972)3.21054797
26L-phenylalanine metabolic process (GO:0006558)3.21005351
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.21005351
28angiotensin maturation (GO:0002003)3.20545909
29regulation of T cell mediated cytotoxicity (GO:0001914)3.20364141
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17306108
31sterol biosynthetic process (GO:0016126)3.11809749
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11760756
33epoxygenase P450 pathway (GO:0019373)3.11191884
34regulation of sequestering of triglyceride (GO:0010889)3.10521568
35triglyceride biosynthetic process (GO:0019432)3.04445073
36fatty acid beta-oxidation (GO:0006635)3.02832534
37regulation of triglyceride catabolic process (GO:0010896)3.02385875
38branched-chain amino acid catabolic process (GO:0009083)3.02136397
39drug catabolic process (GO:0042737)3.01712891
40neutrophil activation involved in immune response (GO:0002283)3.00815857
41acylglycerol biosynthetic process (GO:0046463)3.00798911
42neutral lipid biosynthetic process (GO:0046460)3.00798911
43fatty acid catabolic process (GO:0009062)3.00350983
44ethanol metabolic process (GO:0006067)2.98698030
45lipid oxidation (GO:0034440)2.95743654
46amyloid precursor protein catabolic process (GO:0042987)2.95642008
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93069583
48negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.93058695
49short-chain fatty acid metabolic process (GO:0046459)2.90203912
50positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.88115286
51regulation of cholesterol esterification (GO:0010872)2.87717016
52immunoglobulin mediated immune response (GO:0016064)2.87245404
53fatty acid oxidation (GO:0019395)2.86425627
54signal peptide processing (GO:0006465)2.85318629
55antigen processing and presentation of endogenous antigen (GO:0019883)2.83988737
56reverse cholesterol transport (GO:0043691)2.82291309
57very-low-density lipoprotein particle assembly (GO:0034379)2.81883685
58fructose metabolic process (GO:0006000)2.78679598
59uronic acid metabolic process (GO:0006063)2.75141235
60glucuronate metabolic process (GO:0019585)2.75141235
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74530488
62negative regulation of cell killing (GO:0031342)2.74530488
63plasma lipoprotein particle clearance (GO:0034381)2.73486311
64exogenous drug catabolic process (GO:0042738)2.73450534
65pyrimidine ribonucleoside catabolic process (GO:0046133)2.73120197
66plasma lipoprotein particle remodeling (GO:0034369)2.72364033
67protein-lipid complex remodeling (GO:0034368)2.72364033
68macromolecular complex remodeling (GO:0034367)2.72364033
69nucleotide transmembrane transport (GO:1901679)2.71574674
70monocarboxylic acid catabolic process (GO:0072329)2.69680083
71regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.68922526
72drug metabolic process (GO:0017144)2.67515385
73platelet dense granule organization (GO:0060155)2.66593576
74cellular glucuronidation (GO:0052695)2.65392908
75high-density lipoprotein particle remodeling (GO:0034375)2.64657939
76cholesterol efflux (GO:0033344)2.64407417
77ethanol oxidation (GO:0006069)2.63474739
78cellular response to interleukin-15 (GO:0071350)2.63442728
79positive regulation of steroid metabolic process (GO:0045940)2.62743034
80xenobiotic catabolic process (GO:0042178)2.61431037
81amyloid precursor protein metabolic process (GO:0042982)2.60712755
82sulfur amino acid catabolic process (GO:0000098)2.59620090
83glyoxylate metabolic process (GO:0046487)2.59442379
84DNA deamination (GO:0045006)2.59423751
85acetyl-CoA metabolic process (GO:0006084)2.59303117
86coenzyme catabolic process (GO:0009109)2.59002329
87regulation of cholesterol metabolic process (GO:0090181)2.58318324
88branched-chain amino acid metabolic process (GO:0009081)2.57950331
89phospholipid efflux (GO:0033700)2.56951942
90plasma lipoprotein particle organization (GO:0071827)2.56019977
91negative regulation of response to reactive oxygen species (GO:1901032)2.55417190
92ketone body metabolic process (GO:1902224)2.53719703
93response to lipoprotein particle (GO:0055094)2.53646281
94regulation of cellular extravasation (GO:0002691)2.53596815
95bile acid metabolic process (GO:0008206)2.53494320
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53175459
97valine metabolic process (GO:0006573)2.53085799
98positive regulation of interleukin-17 production (GO:0032740)2.52815604
99regulation of cholesterol biosynthetic process (GO:0045540)2.51470854
100alkaloid metabolic process (GO:0009820)2.50548894
101plasma lipoprotein particle assembly (GO:0034377)2.48388455
102regulation of leukocyte mediated cytotoxicity (GO:0001910)2.46369293
103regulation of triglyceride metabolic process (GO:0090207)2.45979763
104positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.45650867
105triglyceride metabolic process (GO:0006641)2.44896802
106negative regulation of acute inflammatory response (GO:0002674)2.44450314
107positive regulation of defense response to virus by host (GO:0002230)2.43928648
108bile acid biosynthetic process (GO:0006699)2.43730680
109aromatic amino acid family catabolic process (GO:0009074)2.43518108
110positive regulation of cellular amide metabolic process (GO:0034250)2.42961324
111opsonization (GO:0008228)2.41860909
112primary alcohol metabolic process (GO:0034308)2.41442693
113negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.40711105
114biotin metabolic process (GO:0006768)2.40271005
115cellular ketone body metabolic process (GO:0046950)2.40063899
116positive regulation of T-helper 1 type immune response (GO:0002827)2.39451692
117neutrophil activation (GO:0042119)2.38870208
118positive regulation of triglyceride metabolic process (GO:0090208)2.38824782
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37644069
120negative regulation of lipase activity (GO:0060192)2.37621097
121protein-lipid complex subunit organization (GO:0071825)2.37050404
122cofactor catabolic process (GO:0051187)2.36341723
123cellular response to cholesterol (GO:0071397)2.35899768
124positive regulation of cellular amine metabolic process (GO:0033240)2.35212287
125fat-soluble vitamin biosynthetic process (GO:0042362)2.34977685
126regulation of beta-amyloid formation (GO:1902003)2.34838369
127response to dietary excess (GO:0002021)2.33959132
128phenylpropanoid metabolic process (GO:0009698)2.33742274
129L-serine transport (GO:0015825)2.33411280
130ER overload response (GO:0006983)2.31625136
131linoleic acid metabolic process (GO:0043651)2.30727988
132primary alcohol catabolic process (GO:0034310)2.30554596
133vitamin biosynthetic process (GO:0009110)2.30159346
134tyrosine metabolic process (GO:0006570)2.29641389
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.28385612
136regulation of lipoprotein metabolic process (GO:0050746)2.27928191
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27452577
138hormone catabolic process (GO:0042447)2.27289613
139bile acid and bile salt transport (GO:0015721)2.26943621
140acylglycerol metabolic process (GO:0006639)2.25806126
141coenzyme A metabolic process (GO:0015936)2.25481446
142water-soluble vitamin biosynthetic process (GO:0042364)2.25341007
143regulation of cell killing (GO:0031341)2.24920768
144succinate metabolic process (GO:0006105)2.24766521
145cholesterol metabolic process (GO:0008203)2.24479847
146neutral lipid metabolic process (GO:0006638)2.23842064
147peptidyl-glutamic acid carboxylation (GO:0017187)2.23579545
148protein carboxylation (GO:0018214)2.23579545
149regulation of amyloid precursor protein catabolic process (GO:1902991)2.22992238
150aldehyde catabolic process (GO:0046185)2.22959494
151leukocyte migration involved in inflammatory response (GO:0002523)2.22090248
152hydrogen peroxide biosynthetic process (GO:0050665)2.21033600
153positive regulation of icosanoid secretion (GO:0032305)2.20864845
154positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.20396700
155granulocyte activation (GO:0036230)2.18594145
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18578734
157pyrimidine nucleoside catabolic process (GO:0046135)2.18222365
158regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.16868788
159positive regulation of cell killing (GO:0031343)2.16340528
160regulation of inflammatory response to antigenic stimulus (GO:0002861)2.15111324
161regulation of B cell receptor signaling pathway (GO:0050855)2.14071218
162positive regulation of fatty acid transport (GO:2000193)2.13100407
163B cell mediated immunity (GO:0019724)2.12960586
164cellular response to zinc ion (GO:0071294)2.12768728
165adenosine metabolic process (GO:0046085)2.12677645
166regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.11765024
167interferon-gamma-mediated signaling pathway (GO:0060333)2.11225617
168negative regulation of interleukin-12 production (GO:0032695)2.10140771
169positive regulation of prostaglandin secretion (GO:0032308)2.09939236
170reactive oxygen species biosynthetic process (GO:1903409)2.09384629
171L-fucose catabolic process (GO:0042355)2.07818118
172fucose catabolic process (GO:0019317)2.07818118
173L-fucose metabolic process (GO:0042354)2.07818118
174response to interleukin-15 (GO:0070672)2.07483668
175positive regulation of respiratory burst (GO:0060267)2.06799061
176positive regulation of T cell mediated immunity (GO:0002711)2.04956047
177positive regulation of T cell differentiation in thymus (GO:0033089)2.04376058
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.04267608
179regulation of T-helper 1 type immune response (GO:0002825)2.03213275
180response to interferon-beta (GO:0035456)2.03072830
181NADH metabolic process (GO:0006734)2.01382182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.83573834
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56145640
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.35540884
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12677099
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.09289377
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78509647
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.73066416
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.67495200
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46496480
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22893881
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18464083
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15132563
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11989113
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05705820
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82595894
16GATA1_22025678_ChIP-Seq_K562_Human1.81136563
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79054163
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78692491
19CLOCK_20551151_ChIP-Seq_293T_Human1.73618619
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67690272
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.63901950
22* GATA3_26560356_Chip-Seq_TH2_Human1.61705796
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59620616
24NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59620616
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58184868
26IGF1R_20145208_ChIP-Seq_DFB_Human1.55860473
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54621234
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46767189
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41250795
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40775977
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40775892
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39772759
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38123246
34SOX2_20726797_ChIP-Seq_SW620_Human1.38012302
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37487485
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36246931
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36114584
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34942875
39SPI1_23547873_ChIP-Seq_NB4_Human1.34146440
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.32022150
41HTT_18923047_ChIP-ChIP_STHdh_Human1.29840493
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29216634
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27596122
44AR_21572438_ChIP-Seq_LNCaP_Human1.25097552
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.24007285
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23907787
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.22414888
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19643344
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18788917
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18151871
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17653526
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16765961
53BCAT_22108803_ChIP-Seq_LS180_Human1.16178981
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.14601252
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.13999517
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13110842
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12045808
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.11849692
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.11001091
60GATA3_27048872_Chip-Seq_THYMUS_Human1.10891423
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10705840
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10676615
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09334719
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09170311
65MYB_26560356_Chip-Seq_TH2_Human1.09054985
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08962277
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08929628
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.07392115
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.06917644
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.06287450
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05712431
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05622696
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05235919
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05187726
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.04306071
76CDX2_22108803_ChIP-Seq_LS180_Human1.04246323
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03652432
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.03652432
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03138574
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02397359
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01044138
82TAF15_26573619_Chip-Seq_HEK293_Human1.00839678
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00221292
84* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99470575
85VDR_24787735_ChIP-Seq_THP-1_Human0.99021336
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98398209
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98253474
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98169548
89STAT1_20625510_ChIP-Seq_HELA_Human0.98092565
90MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98059633
91GBX2_23144817_ChIP-Seq_PC3_Human0.97829862
92ERG_20517297_ChIP-Seq_VCAP_Human0.97666891
93RXR_22108803_ChIP-Seq_LS180_Human0.97636223
94TAF2_19829295_ChIP-Seq_ESCs_Human0.97104464
95ZNF274_21170338_ChIP-Seq_K562_Hela0.96585168
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96339325
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95511108
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94664737
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93579615
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93204820
101CRX_20693478_ChIP-Seq_RETINA_Mouse0.93129507
102EZH2_27294783_Chip-Seq_NPCs_Mouse0.92698915
103GATA3_21878914_ChIP-Seq_MCF-7_Human0.92646468
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92185315
105TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91707173
106NCOR_22424771_ChIP-Seq_293T_Human0.90293260
107VDR_23849224_ChIP-Seq_CD4+_Human0.89780997
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89685301
109ER_23166858_ChIP-Seq_MCF-7_Human0.89651375
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89650158
111EED_16625203_ChIP-ChIP_MESCs_Mouse0.89191068
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87998258
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87127345
114NANOG_20526341_ChIP-Seq_ESCs_Human0.86893732
115CJUN_26792858_Chip-Seq_BT549_Human0.86846770
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86839187
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85688058
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85546312
119* TP53_22573176_ChIP-Seq_HFKS_Human0.85437170
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85225065
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85042035
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84905272
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84761401
124TP63_23658742_ChIP-Seq_EP156T_Human0.84101095
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84013350
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83685165
127P300_19829295_ChIP-Seq_ESCs_Human0.83358363
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.82578617
129CBP_20019798_ChIP-Seq_JUKART_Human0.82507974
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82507974
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82390296
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82379897
133AR_20517297_ChIP-Seq_VCAP_Human0.82094370
134* TP53_18474530_ChIP-ChIP_U2OS_Human0.81699083
135NANOG_19829295_ChIP-Seq_ESCs_Human0.81275190
136SOX2_19829295_ChIP-Seq_ESCs_Human0.81275190
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80756519
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80109532
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.78835205
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.78809516
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.78470007
142RUNX_20019798_ChIP-Seq_JUKART_Human0.76686808
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74616953
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74595367
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74046297
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72919345
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72897059
148* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72438309
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71910680
150GATA4_25053715_ChIP-Seq_YYC3_Human0.71324819
151VDR_22108803_ChIP-Seq_LS180_Human0.71225321
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.69719694
153* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69635729
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.69454856
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.69025013
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.68251309
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.68236292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.32558333
2MP0005365_abnormal_bile_salt3.00388987
3MP0003806_abnormal_nucleotide_metabolis2.99532491
4MP0003690_abnormal_glial_cell2.88140455
5MP0009840_abnormal_foam_cell2.71595589
6MP0003011_delayed_dark_adaptation2.68715342
7MP0005671_abnormal_response_to2.66915518
8MP0001835_abnormal_antigen_presentation2.42017207
9MP0008875_abnormal_xenobiotic_pharmacok2.38731915
10MP0003724_increased_susceptibility_to2.37205543
11MP0005085_abnormal_gallbladder_physiolo2.27814052
12MP0010329_abnormal_lipoprotein_level2.23305995
13MP0003191_abnormal_cellular_cholesterol2.21893192
14MP0005360_urolithiasis2.19324686
15MP0002837_dystrophic_cardiac_calcinosis2.12811137
16MP0003195_calcinosis2.10479127
17MP0005058_abnormal_lysosome_morphology2.09353891
18MP0000920_abnormal_myelination2.06229642
19MP0002138_abnormal_hepatobiliary_system1.97232155
20MP0003329_amyloid_beta_deposits1.91121022
21MP0005083_abnormal_biliary_tract1.88824230
22MP0002118_abnormal_lipid_homeostasis1.86909921
23MP0005332_abnormal_amino_acid1.86058052
24MP0000604_amyloidosis1.83341588
25MP0010155_abnormal_intestine_physiology1.81868557
26MP0002254_reproductive_system_inflammat1.81236844
27MP0005387_immune_system_phenotype1.78906185
28MP0001790_abnormal_immune_system1.78906185
29MP0003866_abnormal_defecation1.75184098
30MP0001800_abnormal_humoral_immune1.74559541
31MP0008438_abnormal_cutaneous_collagen1.72431058
32MP0005670_abnormal_white_adipose1.72401746
33MP0001845_abnormal_inflammatory_respons1.68452956
34MP0002723_abnormal_immune_serum1.65899922
35MP0004130_abnormal_muscle_cell1.62107981
36MP0000685_abnormal_immune_system1.56776179
37MP0001666_abnormal_nutrient_absorption1.51094421
38MP0002452_abnormal_antigen_presenting1.49403789
39MP0005167_abnormal_blood-brain_barrier1.48683149
40MP0001661_extended_life_span1.48059966
41MP0005584_abnormal_enzyme/coenzyme_acti1.44014298
42MP0003303_peritoneal_inflammation1.41680853
43MP0003186_abnormal_redox_activity1.39046220
44MP0001819_abnormal_immune_cell1.37571720
45MP0002420_abnormal_adaptive_immunity1.37276448
46MP0002971_abnormal_brown_adipose1.36413477
47MP0009780_abnormal_chondrocyte_physiolo1.35804711
48MP0005636_abnormal_mineral_homeostasis1.35679409
49MP0003075_altered_response_to1.35431071
50MP0004185_abnormal_adipocyte_glucose1.35283524
51MP0003183_abnormal_peptide_metabolism1.34665239
52MP0002166_altered_tumor_susceptibility1.34371248
53MP0002295_abnormal_pulmonary_circulatio1.34016919
54MP0003279_aneurysm1.31422000
55MP0005166_decreased_susceptibility_to1.31292219
56MP0000343_altered_response_to1.30743634
57MP0009697_abnormal_copulation1.29947588
58MP0005535_abnormal_body_temperature1.29592972
59MP0002822_catalepsy1.26969701
60MP0002419_abnormal_innate_immunity1.26030546
61MP0003300_gastrointestinal_ulcer1.24764192
62MP0000013_abnormal_adipose_tissue1.24357617
63MP0000609_abnormal_liver_physiology1.22237362
64MP0001986_abnormal_taste_sensitivity1.22178047
65MP0001533_abnormal_skeleton_physiology1.21788725
66MP0009384_cardiac_valve_regurgitation1.18757257
67MP0001765_abnormal_ion_homeostasis1.18455504
68MP0005464_abnormal_platelet_physiology1.18325271
69MP0005379_endocrine/exocrine_gland_phen1.18221003
70MP0005164_abnormal_response_to1.15794402
71MP0003436_decreased_susceptibility_to1.14394227
72MP0009764_decreased_sensitivity_to1.14091627
73MP0003634_abnormal_glial_cell1.14005618
74MP0005666_abnormal_adipose_tissue1.13499652
75MP0002277_abnormal_respiratory_mucosa1.13497977
76MP0004381_abnormal_hair_follicle1.13090257
77MP0006082_CNS_inflammation1.11157835
78MP0002876_abnormal_thyroid_physiology1.08505322
79MP0001853_heart_inflammation1.07886750
80MP0004782_abnormal_surfactant_physiolog1.05733250
81MP0009785_altered_susceptibility_to1.04943917
82MP0000538_abnormal_urinary_bladder1.04925916
83MP0001764_abnormal_homeostasis1.04586298
84MP0003950_abnormal_plasma_membrane1.04428507
85MP0004145_abnormal_muscle_electrophysio1.04407344
86MP0009643_abnormal_urine_homeostasis1.03750634
87MP0002090_abnormal_vision1.03685687
88MP0005451_abnormal_body_composition1.03054788
89MP0005646_abnormal_pituitary_gland1.02974322
90MP0005408_hypopigmentation1.01898658
91MP0001756_abnormal_urination1.00996851
92MP0002148_abnormal_hypersensitivity_rea1.00631594
93MP0005319_abnormal_enzyme/_coenzyme0.97285983
94MP0005334_abnormal_fat_pad0.96588451
95MP0003646_muscle_fatigue0.96303873
96MP0005171_absent_coat_pigmentation0.96051388
97MP0005084_abnormal_gallbladder_morpholo0.95068485
98MP0002796_impaired_skin_barrier0.92641182
99MP0002693_abnormal_pancreas_physiology0.92122407
100MP0003633_abnormal_nervous_system0.91982094
101MP0002132_abnormal_respiratory_system0.91647699
102MP0005310_abnormal_salivary_gland0.91284199
103MP0004043_abnormal_pH_regulation0.90242256
104MP0000716_abnormal_immune_system0.90143443
105MP0000465_gastrointestinal_hemorrhage0.89735807
106MP0001905_abnormal_dopamine_level0.89165516
107MP0008872_abnormal_physiological_respon0.89071324
108MP0002933_joint_inflammation0.88987500
109MP0002405_respiratory_system_inflammati0.88953304
110MP0001984_abnormal_olfaction0.88332921
111MP0008469_abnormal_protein_level0.88161615
112MP0010386_abnormal_urinary_bladder0.88061014
113MP0001542_abnormal_bone_strength0.87769777
114MP0002136_abnormal_kidney_physiology0.86931400
115MP0002909_abnormal_adrenal_gland0.86791600
116MP0004019_abnormal_vitamin_homeostasis0.86202375
117MP0003763_abnormal_thymus_physiology0.85857917
118MP0004883_abnormal_blood_vessel0.85503201
119MP0000516_abnormal_urinary_system0.84970383
120MP0005367_renal/urinary_system_phenotyp0.84970383
121MP0010234_abnormal_vibrissa_follicle0.84939798
122MP0002078_abnormal_glucose_homeostasis0.84808865
123MP0002006_tumorigenesis0.83333769
124MP0001873_stomach_inflammation0.83279352
125MP0001851_eye_inflammation0.83197919
126MP0005375_adipose_tissue_phenotype0.81725792
127MP0006036_abnormal_mitochondrial_physio0.81481442
128MP0000230_abnormal_systemic_arterial0.80988651
129MP0000639_abnormal_adrenal_gland0.80808367
130MP0009642_abnormal_blood_homeostasis0.78898533
131MP0009765_abnormal_xenobiotic_induced0.78525766
132MP0005025_abnormal_response_to0.78432242
133MP0003638_abnormal_response/metabolism_0.77564093
134MP0004147_increased_porphyrin_level0.77345354
135MP0003172_abnormal_lysosome_physiology0.76924008
136MP0001501_abnormal_sleep_pattern0.75676181
137MP0000372_irregular_coat_pigmentation0.75071047
138MP0005448_abnormal_energy_balance0.75046981
139MP0004142_abnormal_muscle_tone0.73939083
140MP0000689_abnormal_spleen_morphology0.73578740
141MP0003252_abnormal_bile_duct0.73556086
142MP0003045_fibrosis0.73020271
143MP0002638_abnormal_pupillary_reflex0.72695248
144MP0009763_increased_sensitivity_to0.71921473
145MP0005000_abnormal_immune_tolerance0.71184113
146MP0005595_abnormal_vascular_smooth0.69694950
147MP0003868_abnormal_feces_composition0.69650033
148MP0005376_homeostasis/metabolism_phenot0.68423340
149MP0001881_abnormal_mammary_gland0.68241963
150MP0003631_nervous_system_phenotype0.67935273

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.01515880
2Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75551405
3Hypoglycemic coma (HP:0001325)3.71469242
4Xanthomatosis (HP:0000991)3.60953628
5Stomatitis (HP:0010280)3.43586768
6Hyperlipoproteinemia (HP:0010980)3.21511515
7Myositis (HP:0100614)3.05803863
8Optic neuritis (HP:0100653)3.05092195
9Retrobulbar optic neuritis (HP:0100654)3.05092195
10Abnormality of fatty-acid metabolism (HP:0004359)3.01468462
11Orchitis (HP:0100796)3.00487458
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00111843
13Prolonged partial thromboplastin time (HP:0003645)2.98821308
14Intrahepatic cholestasis (HP:0001406)2.97907290
15Vacuolated lymphocytes (HP:0001922)2.95950266
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95878729
17Ketosis (HP:0001946)2.89721147
18Hepatic necrosis (HP:0002605)2.87002096
19Ketoacidosis (HP:0001993)2.85321169
20Parakeratosis (HP:0001036)2.83498734
21Abnormality of glycolipid metabolism (HP:0010969)2.78288977
22Abnormality of liposaccharide metabolism (HP:0010968)2.78288977
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.78288977
24Acute encephalopathy (HP:0006846)2.73620239
25Systemic lupus erythematosus (HP:0002725)2.73372244
26Cerebral inclusion bodies (HP:0100314)2.71114693
27Abnormality of glycine metabolism (HP:0010895)2.69764902
28Abnormality of serine family amino acid metabolism (HP:0010894)2.69764902
29Dicarboxylic aciduria (HP:0003215)2.66266389
30Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66266389
31Elevated erythrocyte sedimentation rate (HP:0003565)2.62930411
32Acute necrotizing encephalopathy (HP:0006965)2.61933352
33Hypoglycemic seizures (HP:0002173)2.57934688
34Cerebral edema (HP:0002181)2.52919225
35Hyperglycinuria (HP:0003108)2.52798317
36Chronic diarrhea (HP:0002028)2.52737404
37Amyloidosis (HP:0011034)2.52644610
38Abnormality of the axillary hair (HP:0100134)2.44019282
39Abnormality of secondary sexual hair (HP:0009888)2.44019282
40Abnormal mitochondria in muscle tissue (HP:0008316)2.43384809
41Hypoalphalipoproteinemia (HP:0003233)2.42871791
42Generalized aminoaciduria (HP:0002909)2.41413568
43Deep venous thrombosis (HP:0002625)2.35882672
44Abnormality of the common coagulation pathway (HP:0010990)2.34805320
45Hepatocellular necrosis (HP:0001404)2.34174825
46Axonal loss (HP:0003447)2.33996745
47Hyperammonemia (HP:0001987)2.32907345
48Hepatosplenomegaly (HP:0001433)2.32186236
49Hyperinsulinemic hypoglycemia (HP:0000825)2.30742533
50Complement deficiency (HP:0004431)2.30708778
51Malnutrition (HP:0004395)2.30453143
52Abnormality of urine glucose concentration (HP:0011016)2.27993445
53Glycosuria (HP:0003076)2.27993445
54Dysostosis multiplex (HP:0000943)2.27686155
55Methylmalonic acidemia (HP:0002912)2.27517411
56Recurrent gram-negative bacterial infections (HP:0005420)2.25894491
57Pulmonary infiltrates (HP:0002113)2.25565016
58Mitochondrial inheritance (HP:0001427)2.23913244
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23143018
60Methylmalonic aciduria (HP:0012120)2.20987934
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20958158
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20954741
63Progressive macrocephaly (HP:0004481)2.20923391
64Increased serum pyruvate (HP:0003542)2.20764142
65Abnormality of glycolysis (HP:0004366)2.20764142
66Congenital ichthyosiform erythroderma (HP:0007431)2.18959768
67Abnormality of the vitamin B12 metabolism (HP:0004341)2.18912170
68Abnormality of vitamin B metabolism (HP:0004340)2.17344745
69Petechiae (HP:0000967)2.16645973
70Hypothermia (HP:0002045)2.16247309
71Hypolipoproteinemia (HP:0010981)2.14159746
72Retinal atrophy (HP:0001105)2.13247729
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.08605336
74Abnormality of the intrinsic pathway (HP:0010989)2.07708386
75Large for gestational age (HP:0001520)2.07500712
76Spastic paraparesis (HP:0002313)2.06826814
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05937885
78Aplasia involving bones of the upper limbs (HP:0009823)2.05859768
79Aplasia of the phalanges of the hand (HP:0009802)2.05859768
80Aplasia involving bones of the extremities (HP:0009825)2.05859768
81Eczematoid dermatitis (HP:0000976)2.05387620
82Fat malabsorption (HP:0002630)2.04824195
83Abnormality of proline metabolism (HP:0010907)2.04346907
84Hydroxyprolinuria (HP:0003080)2.04346907
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04016081
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04016081
87Lethargy (HP:0001254)2.03812036
88Hyperphosphaturia (HP:0003109)2.03332662
89Abnormality of macrophages (HP:0004311)2.02750169
90Encephalitis (HP:0002383)2.02379207
91IgG deficiency (HP:0004315)2.02082065
92Obstructive lung disease (HP:0006536)2.00417694
93Chronic obstructive pulmonary disease (HP:0006510)2.00417694
94Reduced antithrombin III activity (HP:0001976)1.99989210
95Tetany (HP:0001281)1.99937097
96Increased intramyocellular lipid droplets (HP:0012240)1.98893125
97Abnormality of T cell number (HP:0011839)1.98744781
98Respiratory distress (HP:0002098)1.98410986
99Symptomatic seizures (HP:0011145)1.97834895
100Hypobetalipoproteinemia (HP:0003563)1.96094543
101Steatorrhea (HP:0002570)1.96044274
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95486686
103Cerebral hemorrhage (HP:0001342)1.95445884
104Recurrent abscess formation (HP:0002722)1.95085234
105Progressive neurologic deterioration (HP:0002344)1.94953917
106Epiphyseal stippling (HP:0010655)1.94598339
107Synostosis involving the elbow (HP:0003938)1.94531046
108Humeroradial synostosis (HP:0003041)1.94531046
109Urinary glycosaminoglycan excretion (HP:0003541)1.92902227
110Mucopolysacchariduria (HP:0008155)1.92902227
111Vasculitis (HP:0002633)1.92828885
112Conjugated hyperbilirubinemia (HP:0002908)1.91597273
113Renal cortical cysts (HP:0000803)1.91141111
114Mediastinal lymphadenopathy (HP:0100721)1.90922681
115Protuberant abdomen (HP:0001538)1.90736887
116Thyroiditis (HP:0100646)1.90344363
117Keratoconjunctivitis sicca (HP:0001097)1.90032807
118Brushfield spots (HP:0001088)1.89867807
119Autoimmune hemolytic anemia (HP:0001890)1.89205927
120Nausea (HP:0002018)1.88285543
121Glomerulonephritis (HP:0000099)1.88227739
122Increased muscle lipid content (HP:0009058)1.87153453
123Anorexia (HP:0002039)1.86738335
124Hemoptysis (HP:0002105)1.86600599
125Keratoconjunctivitis (HP:0001096)1.86556909
126Abnormality of T cells (HP:0002843)1.86500802
127Abnormality of vitamin metabolism (HP:0100508)1.85220193
128Gingival bleeding (HP:0000225)1.84198321
129Abnormality of endocrine pancreas physiology (HP:0012093)1.84138000
130Abnormality of the pancreatic islet cells (HP:0006476)1.84138000
131Increased CSF lactate (HP:0002490)1.83767574
132Increased cerebral lipofuscin (HP:0011813)1.83528298
133Metaphyseal dysplasia (HP:0100255)1.81734715
134Renal Fanconi syndrome (HP:0001994)1.81139586
135Pulmonary embolism (HP:0002204)1.81072771
136Onycholysis (HP:0001806)1.80593113
137T lymphocytopenia (HP:0005403)1.80527244
138Purpura (HP:0000979)1.80360753
139Vomiting (HP:0002013)1.80058686
140Gangrene (HP:0100758)1.79808467
141Urticaria (HP:0001025)1.79373311
142Abnormality of the prostate (HP:0008775)1.78495056
143Delayed CNS myelination (HP:0002188)1.78433302
144Cerebral palsy (HP:0100021)1.78278082
145Recurrent bacterial skin infections (HP:0005406)1.77790222
146Hyperglycinemia (HP:0002154)1.77608892
147Barrel-shaped chest (HP:0001552)1.77037741
148Hypokinesia (HP:0002375)1.76273365
149Epiphyseal dysplasia (HP:0002656)1.74003842
150Joint hemorrhage (HP:0005261)1.72735888
151Pancreatitis (HP:0001733)1.72191873
152Vascular calcification (HP:0004934)1.71769764
153Metabolic acidosis (HP:0001942)1.71075015
154Epidermoid cyst (HP:0200040)1.71041168
155Late onset (HP:0003584)1.70511594
156Respiratory failure (HP:0002878)1.70423459
157Paraparesis (HP:0002385)1.70162333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.68517660
2EPHB13.23590618
3STK392.85667655
4INSRR2.84870359
5TESK22.40448919
6ERN12.36695072
7IRAK32.29331775
8TNIK2.28907886
9MST42.18329041
10MAPK152.05138271
11MAP4K21.96955387
12IRAK41.96447235
13ACVR1B1.85397476
14MAPKAPK51.84645315
15PDK21.73790881
16RIPK41.62245093
17LMTK21.59938137
18OXSR11.58287941
19MAP4K11.54994707
20IKBKB1.42454390
21IRAK11.41975713
22WNK41.39375080
23OBSCN1.38568767
24MUSK1.36641963
25TEC1.35921273
26JAK31.35137331
27PBK1.33374569
28SIK11.31366799
29TLK11.29301918
30PIK3CG1.27502776
31BMPR21.24954561
32FGR1.24872232
33SYK1.24431005
34MET1.21671026
35MYLK1.21216207
36BCR1.18075454
37NTRK11.17053491
38MAP3K111.16728412
39ITK1.15932278
40MAPK121.15031540
41CLK11.14635621
42BMPR1B1.14226342
43MAPKAPK31.08396775
44ZAP701.08132923
45MST1R1.07700474
46TBK11.05988617
47GRK71.05346665
48TRPM71.02285697
49CSK1.00738297
50CAMK1D1.00227568
51FGFR41.00174121
52EPHA40.98343048
53FES0.97723965
54PINK10.94133297
55PDK40.93936521
56PDK30.93936521
57FGFR20.93451795
58NUAK10.92824280
59CSF1R0.92409152
60TESK10.92058711
61TNK20.91844043
62EPHA30.88123658
63TAOK10.88038556
64KDR0.87215365
65NLK0.86003058
66MATK0.85766009
67PIM20.85680003
68EIF2AK30.84511100
69PIK3CA0.84028651
70GRK50.83555636
71PHKG10.82620602
72PHKG20.82620602
73PRKCQ0.81097327
74TYK20.80991374
75PRKCE0.80484118
76MAP3K120.80256999
77PDPK10.80018924
78IRAK20.79589041
79MAP3K20.79461609
80ZAK0.78761524
81MAP3K140.78342712
82TXK0.77504516
83CAMK2D0.75641039
84ERBB30.75173161
85PKN10.73995673
86CASK0.73889508
87ADRBK10.73532327
88TIE10.73422202
89PRKCH0.70740330
90PRKAA20.69641709
91PAK30.69361289
92CAMK2G0.69030977
93SCYL20.68734558
94TGFBR20.67854268
95HCK0.67835236
96JAK20.67061652
97IKBKE0.66564596
98BTK0.66444271
99MAPK40.65201026
100NEK60.65167648
101BLK0.64727861
102MAP3K30.63939143
103IGF1R0.62220406
104ARAF0.60957222
105MAP2K20.60945202
106TRIB30.60517440
107CAMKK20.60298917
108KIT0.59465071
109AKT30.58854770
110JAK10.57835574
111FRK0.57450199
112SIK30.56511810
113MAP3K10.56123079
114ADRBK20.56099154
115GRK60.55389259
116ABL20.55115691
117PRKG20.54544895
118LIMK10.54453773
119LYN0.53015406
120FER0.52985052
121CAMK2A0.52626695
122CDK190.51058373
123TAOK30.50914737
124DAPK20.50901358
125GRK10.50816252
126MAP2K10.50815619
127LCK0.50719965
128MAP2K60.50457127
129CAMK1G0.49746304
130CHUK0.48947445
131SGK2230.48944986
132SGK4940.48944986
133PRKCZ0.47915514
134PRKCD0.46534710
135STK160.45919310
136MAP3K130.44231627
137PRKCA0.44230966
138PDK10.43333852
139LRRK20.41264267

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.98020128
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.76469196
3Steroid biosynthesis_Homo sapiens_hsa001003.32976160
4Fatty acid metabolism_Homo sapiens_hsa012122.78949791
5Sulfur metabolism_Homo sapiens_hsa009202.57467506
6Propanoate metabolism_Homo sapiens_hsa006402.54503213
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52679318
8Fatty acid degradation_Homo sapiens_hsa000712.47803402
9Graft-versus-host disease_Homo sapiens_hsa053322.20533484
10Allograft rejection_Homo sapiens_hsa053302.17940817
11Protein export_Homo sapiens_hsa030602.17492167
12Histidine metabolism_Homo sapiens_hsa003402.15060180
13Type I diabetes mellitus_Homo sapiens_hsa049402.14231072
14Asthma_Homo sapiens_hsa053102.13428207
15Autoimmune thyroid disease_Homo sapiens_hsa053202.08280588
16Peroxisome_Homo sapiens_hsa041462.04519537
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02632999
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.00521390
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99219742
20Fatty acid biosynthesis_Homo sapiens_hsa000611.98771263
21PPAR signaling pathway_Homo sapiens_hsa033201.86356299
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.84860299
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75288108
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72984365
25Staphylococcus aureus infection_Homo sapiens_hsa051501.66622992
26Oxidative phosphorylation_Homo sapiens_hsa001901.62305085
27Nitrogen metabolism_Homo sapiens_hsa009101.61358328
28Butanoate metabolism_Homo sapiens_hsa006501.54742772
29Pyruvate metabolism_Homo sapiens_hsa006201.51958300
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42931716
31Retinol metabolism_Homo sapiens_hsa008301.41632135
32beta-Alanine metabolism_Homo sapiens_hsa004101.41346022
33Tryptophan metabolism_Homo sapiens_hsa003801.40876168
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39547437
35Sphingolipid metabolism_Homo sapiens_hsa006001.39145991
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38432741
37Complement and coagulation cascades_Homo sapiens_hsa046101.37947909
38Antigen processing and presentation_Homo sapiens_hsa046121.32595825
39Chemical carcinogenesis_Homo sapiens_hsa052041.31992300
40Renin-angiotensin system_Homo sapiens_hsa046141.31418969
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31302799
42Proteasome_Homo sapiens_hsa030501.30847025
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28745834
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.17128177
45Leishmaniasis_Homo sapiens_hsa051401.14312719
46Primary immunodeficiency_Homo sapiens_hsa053401.13821704
47Phenylalanine metabolism_Homo sapiens_hsa003601.13366220
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.13347100
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12606509
50Ether lipid metabolism_Homo sapiens_hsa005651.08909401
51Parkinsons disease_Homo sapiens_hsa050121.08474391
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06989732
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06570375
54Tyrosine metabolism_Homo sapiens_hsa003501.04314784
55Vitamin digestion and absorption_Homo sapiens_hsa049771.02926695
56Arginine and proline metabolism_Homo sapiens_hsa003301.02439876
57Lysosome_Homo sapiens_hsa041421.01359411
58Starch and sucrose metabolism_Homo sapiens_hsa005001.01008513
59Alzheimers disease_Homo sapiens_hsa050101.00143829
60Arginine biosynthesis_Homo sapiens_hsa002200.94929396
61Caffeine metabolism_Homo sapiens_hsa002320.94077515
62Hematopoietic cell lineage_Homo sapiens_hsa046400.91403730
63ABC transporters_Homo sapiens_hsa020100.90572859
64Glycerolipid metabolism_Homo sapiens_hsa005610.90103053
65Other glycan degradation_Homo sapiens_hsa005110.90083420
66Fat digestion and absorption_Homo sapiens_hsa049750.88109929
67Folate biosynthesis_Homo sapiens_hsa007900.85736539
68Regulation of autophagy_Homo sapiens_hsa041400.85613827
69Carbon metabolism_Homo sapiens_hsa012000.82386740
70Vitamin B6 metabolism_Homo sapiens_hsa007500.80635747
71Fructose and mannose metabolism_Homo sapiens_hsa000510.77753121
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.77657836
73Tuberculosis_Homo sapiens_hsa051520.75524106
74Glutathione metabolism_Homo sapiens_hsa004800.74825351
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74724452
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74575066
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73612084
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72480714
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72282514
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72044638
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68752848
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68599204
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67980048
84Linoleic acid metabolism_Homo sapiens_hsa005910.66262690
85Metabolic pathways_Homo sapiens_hsa011000.65135850
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63951972
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62865275
88Viral myocarditis_Homo sapiens_hsa054160.60932706
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60875953
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60255076
91Rheumatoid arthritis_Homo sapiens_hsa053230.60236869
92Bile secretion_Homo sapiens_hsa049760.58975056
93Vibrio cholerae infection_Homo sapiens_hsa051100.57008014
94Arachidonic acid metabolism_Homo sapiens_hsa005900.55836846
95Legionellosis_Homo sapiens_hsa051340.55673510
96Phagosome_Homo sapiens_hsa041450.55272591
97Sulfur relay system_Homo sapiens_hsa041220.51648918
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50682528
99Pentose phosphate pathway_Homo sapiens_hsa000300.49911918
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49539963
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.48825359
102Osteoclast differentiation_Homo sapiens_hsa043800.46856707
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45932353
104Collecting duct acid secretion_Homo sapiens_hsa049660.44105285
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.43821034
106Huntingtons disease_Homo sapiens_hsa050160.43284603
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.42936720
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42469714
109Malaria_Homo sapiens_hsa051440.41991362
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.40276043
111African trypanosomiasis_Homo sapiens_hsa051430.39469939
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34629438
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.34444641
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34311907
115Ovarian steroidogenesis_Homo sapiens_hsa049130.33001349
116Mineral absorption_Homo sapiens_hsa049780.32254069
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30575836
118Galactose metabolism_Homo sapiens_hsa000520.27098352
119Biosynthesis of amino acids_Homo sapiens_hsa012300.26932068
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26251291
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25341092
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24363752
123Pancreatic secretion_Homo sapiens_hsa049720.24069812
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.23714000
125Prion diseases_Homo sapiens_hsa050200.23072895
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22611089
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19880574
128Pertussis_Homo sapiens_hsa051330.19672148

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