DHRS7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.59351932
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.13142344
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86072099
4ATP synthesis coupled proton transport (GO:0015986)4.86072099
5central nervous system myelination (GO:0022010)4.85579091
6axon ensheathment in central nervous system (GO:0032291)4.85579091
7proteasome assembly (GO:0043248)4.74743517
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58844803
9water-soluble vitamin biosynthetic process (GO:0042364)4.41137832
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.29472168
11respiratory electron transport chain (GO:0022904)4.25807327
12protein neddylation (GO:0045116)4.21570817
13ribosomal large subunit biogenesis (GO:0042273)4.17436694
14electron transport chain (GO:0022900)4.13528390
15termination of RNA polymerase III transcription (GO:0006386)4.12327357
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.12327357
17GTP biosynthetic process (GO:0006183)4.08384911
18fatty acid elongation (GO:0030497)4.02481856
19rRNA modification (GO:0000154)3.86352749
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.83860528
21NADH dehydrogenase complex assembly (GO:0010257)3.83860528
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83860528
23respiratory chain complex IV assembly (GO:0008535)3.82813910
24protein complex biogenesis (GO:0070271)3.82789905
25regulation of mitochondrial translation (GO:0070129)3.82083466
26quinone biosynthetic process (GO:1901663)3.77615400
27ubiquinone biosynthetic process (GO:0006744)3.77615400
28L-methionine salvage (GO:0071267)3.75426626
29L-methionine biosynthetic process (GO:0071265)3.75426626
30amino acid salvage (GO:0043102)3.75426626
31mannosylation (GO:0097502)3.75110281
32ribosomal small subunit biogenesis (GO:0042274)3.72230173
33hydrogen ion transmembrane transport (GO:1902600)3.58338852
34cilium movement (GO:0003341)3.56822122
35GPI anchor biosynthetic process (GO:0006506)3.56332152
36protein localization to mitochondrion (GO:0070585)3.55433468
37ubiquinone metabolic process (GO:0006743)3.54939630
38folic acid transport (GO:0015884)3.48350761
39protein deneddylation (GO:0000338)3.47794324
40heme transport (GO:0015886)3.47335440
41folic acid metabolic process (GO:0046655)3.44654261
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42217760
43mitochondrial respiratory chain complex assembly (GO:0033108)3.41035213
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37562297
45long-chain fatty acid biosynthetic process (GO:0042759)3.37250190
46proton transport (GO:0015992)3.36486437
47rRNA methylation (GO:0031167)3.34210698
48UTP biosynthetic process (GO:0006228)3.33897598
49energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.33132875
50ATP hydrolysis coupled proton transport (GO:0015991)3.33132875
51hydrogen transport (GO:0006818)3.31620558
52cytochrome complex assembly (GO:0017004)3.28137990
53maturation of SSU-rRNA (GO:0030490)3.24046509
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21907367
55guanosine-containing compound biosynthetic process (GO:1901070)3.21178595
56RNA capping (GO:0036260)3.20895199
577-methylguanosine RNA capping (GO:0009452)3.20895199
58galactose metabolic process (GO:0006012)3.17188194
59GPI anchor metabolic process (GO:0006505)3.16895232
607-methylguanosine mRNA capping (GO:0006370)3.16875047
61inner mitochondrial membrane organization (GO:0007007)3.13513937
62ATP biosynthetic process (GO:0006754)3.12675698
63DNA deamination (GO:0045006)3.12363328
64chaperone-mediated protein transport (GO:0072321)3.11555247
65isoprenoid biosynthetic process (GO:0008299)3.09391054
66protein-cofactor linkage (GO:0018065)3.08902044
67positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.03838171
68intracellular protein transmembrane import (GO:0044743)3.03293718
69transcription elongation from RNA polymerase I promoter (GO:0006362)3.03056579
70cholesterol biosynthetic process (GO:0006695)3.02487725
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02066441
72aldehyde catabolic process (GO:0046185)2.98671306
73CTP metabolic process (GO:0046036)2.98216162
74CTP biosynthetic process (GO:0006241)2.98216162
75preassembly of GPI anchor in ER membrane (GO:0016254)2.97300342
76negative regulation of execution phase of apoptosis (GO:1900118)2.96331517
77nucleotide transmembrane transport (GO:1901679)2.94858594
78viral transcription (GO:0019083)2.92659366
79regulation of cellular amino acid metabolic process (GO:0006521)2.92577850
80protein targeting to mitochondrion (GO:0006626)2.91563015
81termination of RNA polymerase I transcription (GO:0006363)2.91400257
82galactose catabolic process (GO:0019388)2.91192387
83peptidyl-histidine modification (GO:0018202)2.90745884
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87621913
85cotranslational protein targeting to membrane (GO:0006613)2.86742431
86translational termination (GO:0006415)2.86415998
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.86150187
88translation (GO:0006412)2.85812653
89regulation of feeding behavior (GO:0060259)2.85671340
90mitochondrial transport (GO:0006839)2.85154332
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84822599
92replication fork processing (GO:0031297)2.84281362
93quinone metabolic process (GO:1901661)2.83540639
94UTP metabolic process (GO:0046051)2.82112690
95establishment of protein localization to mitochondrion (GO:0072655)2.81581937
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81113729
97cellular component biogenesis (GO:0044085)2.80214465
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79526454
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79403943
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79403943
101pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.78656218
102DNA damage response, detection of DNA damage (GO:0042769)2.78301056
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78187862
104protein targeting to ER (GO:0045047)2.76191893
105cullin deneddylation (GO:0010388)2.74972955
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72761773
107transcription from RNA polymerase I promoter (GO:0006360)2.72268266
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71484070
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71484070
110signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71484070
111sterol biosynthetic process (GO:0016126)2.70864520
112deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70568138
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70318504
114positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68824419
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.68624018
116tRNA processing (GO:0008033)2.68593794
117oxidative phosphorylation (GO:0006119)2.68434403
118deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.68284201
119negative regulation of ligase activity (GO:0051352)2.68034843
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68034843
121ribonucleoprotein complex biogenesis (GO:0022613)2.67828452
122RNA methylation (GO:0001510)2.67478183
123ribosomal small subunit assembly (GO:0000028)2.67374026
124protein localization to endoplasmic reticulum (GO:0070972)2.66728053
125tRNA methylation (GO:0030488)2.66543932
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.65860751
127intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65330496
128signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65330496
129epithelial cilium movement (GO:0003351)2.65311185
130nucleoside triphosphate biosynthetic process (GO:0009142)2.64245532
131methionine biosynthetic process (GO:0009086)2.64210336
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63007958
133purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62805185
134signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62474947
135purine nucleotide salvage (GO:0032261)2.62412904
136vitamin biosynthetic process (GO:0009110)2.61854344
137positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61737820
138platelet dense granule organization (GO:0060155)2.60467196
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59910440
140pseudouridine synthesis (GO:0001522)2.58588850
141regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.57924912
142base-excision repair, AP site formation (GO:0006285)2.55895929
143spliceosomal snRNP assembly (GO:0000387)2.53254902
144positive regulation of ligase activity (GO:0051351)2.51990689
145glyoxylate metabolic process (GO:0046487)2.51385168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.07976319
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.06437066
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.98677939
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33704818
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82511133
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.37358521
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27765569
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.09481759
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96112830
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.91023691
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76882963
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61760721
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59023390
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45191967
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.40832527
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.35329827
17ZNF274_21170338_ChIP-Seq_K562_Hela2.18145013
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14947402
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12780217
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10886616
21ZNF263_19887448_ChIP-Seq_K562_Human2.02636351
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.00701204
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99427064
24DCP1A_22483619_ChIP-Seq_HELA_Human1.91598963
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85514101
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.80317271
27VDR_23849224_ChIP-Seq_CD4+_Human1.76727796
28IRF1_19129219_ChIP-ChIP_H3396_Human1.72196076
29FOXP3_21729870_ChIP-Seq_TREG_Human1.70569707
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69077078
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68700154
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65243980
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65011933
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64887281
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.63828160
36VDR_22108803_ChIP-Seq_LS180_Human1.59439848
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57874381
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57479671
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55147381
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51497429
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51195672
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45930690
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45392681
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45086764
45* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43871165
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41440460
47ELK1_19687146_ChIP-ChIP_HELA_Human1.41369289
48* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36961960
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35779275
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33561537
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32002951
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.31649958
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31109078
54GBX2_23144817_ChIP-Seq_PC3_Human1.28864182
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27287313
56* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27081401
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26549329
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26293817
59* ELK1_22589737_ChIP-Seq_MCF10A_Human1.24552118
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.23146335
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23004352
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21469609
63TTF2_22483619_ChIP-Seq_HELA_Human1.21165216
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20124057
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19100180
66TP53_22573176_ChIP-Seq_HFKS_Human1.18871119
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.18569122
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18243617
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18131246
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18033479
71IGF1R_20145208_ChIP-Seq_DFB_Human1.17304499
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.17075006
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17075006
74AR_20517297_ChIP-Seq_VCAP_Human1.15934078
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15590926
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14450390
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13481962
78MYC_18940864_ChIP-ChIP_HL60_Human1.12936684
79EWS_26573619_Chip-Seq_HEK293_Human1.12470695
80* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11612035
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11446457
82P300_18555785_Chip-Seq_ESCs_Mouse1.10461130
83* KDM5A_27292631_Chip-Seq_BREAST_Human1.07954758
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07678131
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07392304
86* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07221507
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.06491784
88P53_22387025_ChIP-Seq_ESCs_Mouse1.06170236
89SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06072681
90FUS_26573619_Chip-Seq_HEK293_Human1.04685058
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03426080
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.01888213
93ERG_20517297_ChIP-Seq_VCAP_Human1.01481029
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00381269
95ER_23166858_ChIP-Seq_MCF-7_Human0.99726273
96* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99581228
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99440794
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.99156717
99NMYC_18555785_Chip-Seq_ESCs_Mouse0.99089519
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.98363017
101NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98059619
102NCOR_22424771_ChIP-Seq_293T_Human0.97893485
103SOX2_18555785_Chip-Seq_ESCs_Mouse0.97285316
104* GABP_19822575_ChIP-Seq_HepG2_Human0.96905822
105GATA3_21878914_ChIP-Seq_MCF-7_Human0.96785703
106KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96738404
107XRN2_22483619_ChIP-Seq_HELA_Human0.96429131
108TAF15_26573619_Chip-Seq_HEK293_Human0.94942378
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94546423
110P53_21459846_ChIP-Seq_SAOS-2_Human0.94294542
111CMYC_18555785_Chip-Seq_ESCs_Mouse0.94173085
112OCT4_18555785_Chip-Seq_ESCs_Mouse0.94057205
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92862637
114HOXB7_26014856_ChIP-Seq_BT474_Human0.92438742
115PU1_27457419_Chip-Seq_LIVER_Mouse0.91565213
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90640598
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.89319385
118CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89070524
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.89057782
120ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89021813
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88342931
122SOX2_19829295_ChIP-Seq_ESCs_Human0.88186705
123NANOG_19829295_ChIP-Seq_ESCs_Human0.88186705
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87893834
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87745216
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87711109
127NANOG_20526341_ChIP-Seq_ESCs_Human0.87238532
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86851672
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86678243
130TAF2_19829295_ChIP-Seq_ESCs_Human0.86300200
131HTT_18923047_ChIP-ChIP_STHdh_Human0.86220473
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85592009
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85170243
134ERA_21632823_ChIP-Seq_H3396_Human0.85165415
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84718176
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83939845
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.83882520
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82660866
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.82377654
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82309191
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.81352638
142ELF5_23300383_ChIP-Seq_T47D_Human0.79492863
143CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78910676
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78876856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.91491916
2MP0009379_abnormal_foot_pigmentation3.09730170
3MP0001188_hyperpigmentation2.93762737
4MP0002102_abnormal_ear_morphology2.93306465
5MP0004381_abnormal_hair_follicle2.89349363
6MP0008875_abnormal_xenobiotic_pharmacok2.77899090
7MP0005670_abnormal_white_adipose2.60579365
8MP0005171_absent_coat_pigmentation2.56255322
9MP0003806_abnormal_nucleotide_metabolis2.56010775
10MP0004858_abnormal_nervous_system2.50954455
11MP0001529_abnormal_vocalization2.48331484
12MP0002876_abnormal_thyroid_physiology2.47246247
13MP0005084_abnormal_gallbladder_morpholo2.41922087
14MP0003186_abnormal_redox_activity2.35369070
15MP0003646_muscle_fatigue2.35283477
16MP0003718_maternal_effect2.32106677
17MP0005451_abnormal_body_composition2.19464465
18MP0003011_delayed_dark_adaptation2.11230021
19MP0004142_abnormal_muscle_tone2.10820522
20MP0002837_dystrophic_cardiac_calcinosis2.09870774
21MP0000566_synostosis2.09534004
22MP0005409_darkened_coat_color2.08191510
23MP0000372_irregular_coat_pigmentation2.06904124
24MP0002132_abnormal_respiratory_system2.02030386
25MP0002653_abnormal_ependyma_morphology1.98864692
26MP0004742_abnormal_vestibular_system1.96603591
27MP0001764_abnormal_homeostasis1.94170096
28MP0005379_endocrine/exocrine_gland_phen1.89060501
29MP0006292_abnormal_olfactory_placode1.89029108
30MP0000920_abnormal_myelination1.88675115
31MP0008058_abnormal_DNA_repair1.85132944
32MP0008872_abnormal_physiological_respon1.81138995
33MP0001905_abnormal_dopamine_level1.80728369
34MP0002277_abnormal_respiratory_mucosa1.79385906
35MP0003786_premature_aging1.76498523
36MP0008260_abnormal_autophagy1.76192898
37MP0002638_abnormal_pupillary_reflex1.69397587
38MP0004147_increased_porphyrin_level1.65276083
39MP0008877_abnormal_DNA_methylation1.56565237
40MP0002160_abnormal_reproductive_system1.56333729
41MP0005266_abnormal_metabolism1.55855650
42MP0006036_abnormal_mitochondrial_physio1.54976295
43MP0001986_abnormal_taste_sensitivity1.53600322
44MP0005365_abnormal_bile_salt1.53542686
45MP0001727_abnormal_embryo_implantation1.48578912
46MP0001661_extended_life_span1.47041759
47MP0005666_abnormal_adipose_tissue1.45490152
48MP0001542_abnormal_bone_strength1.45301560
49MP0005075_abnormal_melanosome_morpholog1.44979369
50MP0008932_abnormal_embryonic_tissue1.44683458
51MP0004145_abnormal_muscle_electrophysio1.39523800
52MP0002095_abnormal_skin_pigmentation1.35798211
53MP0005174_abnormal_tail_pigmentation1.34540213
54MP0003724_increased_susceptibility_to1.32700677
55MP0003195_calcinosis1.32593738
56MP0009046_muscle_twitch1.32526345
57MP0003690_abnormal_glial_cell1.26071637
58MP0001968_abnormal_touch/_nociception1.25155467
59MP0008057_abnormal_DNA_replication1.24780564
60MP0009697_abnormal_copulation1.23150185
61MP0005332_abnormal_amino_acid1.20418183
62MP0001324_abnormal_eye_pigmentation1.19264899
63MP0004133_heterotaxia1.18378450
64MP0005645_abnormal_hypothalamus_physiol1.18288886
65MP0005410_abnormal_fertilization1.16974610
66MP0005551_abnormal_eye_electrophysiolog1.16360067
67MP0000026_abnormal_inner_ear1.13831332
68MP0000015_abnormal_ear_pigmentation1.12452383
69MP0005389_reproductive_system_phenotype1.11743713
70MP0006276_abnormal_autonomic_nervous1.09544811
71MP0003693_abnormal_embryo_hatching1.08899889
72MP0002139_abnormal_hepatobiliary_system1.08729653
73MP0003938_abnormal_ear_development1.07825672
74MP0005377_hearing/vestibular/ear_phenot1.07777173
75MP0003878_abnormal_ear_physiology1.07777173
76MP0001963_abnormal_hearing_physiology1.07575481
77MP0001485_abnormal_pinna_reflex1.06657029
78MP0003950_abnormal_plasma_membrane1.05608379
79MP0003880_abnormal_central_pattern1.05323233
80MP0003111_abnormal_nucleus_morphology1.02641217
81MP0002163_abnormal_gland_morphology1.01118177
82MP0006082_CNS_inflammation1.00564248
83MP0003941_abnormal_skin_development0.99771099
84MP0002138_abnormal_hepatobiliary_system0.99329733
85MP0005375_adipose_tissue_phenotype0.97186671
86MP0002234_abnormal_pharynx_morphology0.97068147
87MP0000427_abnormal_hair_cycle0.94715113
88MP0000462_abnormal_digestive_system0.94446719
89MP0000358_abnormal_cell_content/0.93998910
90MP0005636_abnormal_mineral_homeostasis0.93083721
91MP0001293_anophthalmia0.92933886
92MP0005646_abnormal_pituitary_gland0.91797166
93MP0005395_other_phenotype0.91781178
94MP0009745_abnormal_behavioral_response0.89886312
95MP0002332_abnormal_exercise_endurance0.89158706
96MP0000762_abnormal_tongue_morphology0.88391647
97MP0004019_abnormal_vitamin_homeostasis0.87778016
98MP0000749_muscle_degeneration0.87715775
99MP0002148_abnormal_hypersensitivity_rea0.86317980
100MP0002938_white_spotting0.85502311
101MP0004185_abnormal_adipocyte_glucose0.85073848
102MP0004043_abnormal_pH_regulation0.82607836
103MP0004215_abnormal_myocardial_fiber0.81705236
104MP0002733_abnormal_thermal_nociception0.81054823
105MP0001984_abnormal_olfaction0.80596660
106MP0001664_abnormal_digestion0.80393393
107MP0002736_abnormal_nociception_after0.80157175
108MP0001486_abnormal_startle_reflex0.77924800
109MP0002210_abnormal_sex_determination0.77480695
110MP0005253_abnormal_eye_physiology0.76885858
111MP0001919_abnormal_reproductive_system0.76361533
112MP0001929_abnormal_gametogenesis0.75096927
113MP0000613_abnormal_salivary_gland0.75096014
114MP0006072_abnormal_retinal_apoptosis0.74156029
115MP0005408_hypopigmentation0.73808430
116MP0003121_genomic_imprinting0.73762594
117MP0004957_abnormal_blastocyst_morpholog0.73425569
118MP0001501_abnormal_sleep_pattern0.72829993
119MP0005058_abnormal_lysosome_morphology0.72677632
120MP0002971_abnormal_brown_adipose0.72341722
121MP0010094_abnormal_chromosome_stability0.71981920
122MP0003123_paternal_imprinting0.71914014
123MP0005085_abnormal_gallbladder_physiolo0.71680350
124MP0005319_abnormal_enzyme/_coenzyme0.70715752
125MP0006035_abnormal_mitochondrial_morpho0.69375597
126MP0003137_abnormal_impulse_conducting0.68257947
127MP0001756_abnormal_urination0.68148747
128MP0002295_abnormal_pulmonary_circulatio0.68080142
129MP0001881_abnormal_mammary_gland0.68068229
130MP0000653_abnormal_sex_gland0.67732422
131MP0002272_abnormal_nervous_system0.67705845
132MP0002090_abnormal_vision0.67466665
133MP0009785_altered_susceptibility_to0.66284467
134MP0001970_abnormal_pain_threshold0.65829355
135MP0005334_abnormal_fat_pad0.65658178
136MP0000631_abnormal_neuroendocrine_gland0.65546677
137MP0000750_abnormal_muscle_regeneration0.65402942
138MP0001853_heart_inflammation0.64174616
139MP0008004_abnormal_stomach_pH0.63750635
140MP0005423_abnormal_somatic_nervous0.61990674
141MP0004782_abnormal_surfactant_physiolog0.61809070
142MP0002229_neurodegeneration0.60846328
143MP0005376_homeostasis/metabolism_phenot0.60681794
144MP0002735_abnormal_chemical_nociception0.60529347
145MP0002752_abnormal_somatic_nervous0.59914171
146MP0000681_abnormal_thyroid_gland0.59761935
147MP0008438_abnormal_cutaneous_collagen0.58513145
148MP0009333_abnormal_splenocyte_physiolog0.56694051
149MP0005671_abnormal_response_to0.56193434
150MP0005195_abnormal_posterior_eye0.55846158

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32786371
2Abnormal respiratory motile cilium physiology (HP:0012261)4.04489922
3Mitochondrial inheritance (HP:0001427)4.00403567
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.89663438
5Hepatocellular necrosis (HP:0001404)3.83878728
63-Methylglutaconic aciduria (HP:0003535)3.77241907
7Abnormal mitochondria in muscle tissue (HP:0008316)3.71590770
8Hepatic necrosis (HP:0002605)3.67624416
9Acute encephalopathy (HP:0006846)3.67470414
10Renal Fanconi syndrome (HP:0001994)3.62901766
11Microvesicular hepatic steatosis (HP:0001414)3.61242111
12Increased hepatocellular lipid droplets (HP:0006565)3.54295315
13Progressive macrocephaly (HP:0004481)3.50187540
14Increased CSF lactate (HP:0002490)3.44523193
15Lipid accumulation in hepatocytes (HP:0006561)3.28305199
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26230623
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.23868109
18Parakeratosis (HP:0001036)3.19314894
19Abnormality of glycolysis (HP:0004366)3.17072352
20Increased serum pyruvate (HP:0003542)3.17072352
21Cerebral hypomyelination (HP:0006808)3.06826587
22Cerebral edema (HP:0002181)3.01789488
23Congenital ichthyosiform erythroderma (HP:0007431)2.96159902
24Molar tooth sign on MRI (HP:0002419)2.94518751
25Abnormality of midbrain morphology (HP:0002418)2.94518751
26Increased serum lactate (HP:0002151)2.84094345
27Pancreatic cysts (HP:0001737)2.82688565
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81476955
29Lactic acidosis (HP:0003128)2.78333244
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70185646
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70185646
32Duplicated collecting system (HP:0000081)2.69200940
33Pancreatic fibrosis (HP:0100732)2.66261456
34Exercise intolerance (HP:0003546)2.64540701
35Optic disc pallor (HP:0000543)2.62871965
36Prolonged neonatal jaundice (HP:0006579)2.62472501
37Reticulocytopenia (HP:0001896)2.61641565
38Hypoplastic pelvis (HP:0008839)2.60775555
39Prostate neoplasm (HP:0100787)2.60194330
40Leukodystrophy (HP:0002415)2.59981262
41Respiratory failure (HP:0002878)2.56786782
42Abnormality of renal resorption (HP:0011038)2.55809887
43True hermaphroditism (HP:0010459)2.52841391
44Congenital, generalized hypertrichosis (HP:0004540)2.52171517
45Conical tooth (HP:0000698)2.51908116
46Abnormal respiratory motile cilium morphology (HP:0005938)2.48246676
47Abnormal respiratory epithelium morphology (HP:0012253)2.48246676
48Chromsome breakage (HP:0040012)2.43681104
49Congenital stationary night blindness (HP:0007642)2.41548296
50Abnormality of the renal collecting system (HP:0004742)2.39292809
51Increased intramyocellular lipid droplets (HP:0012240)2.38868138
52Abnormality of alanine metabolism (HP:0010916)2.38633690
53Hyperalaninemia (HP:0003348)2.38633690
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38633690
55Macrocytic anemia (HP:0001972)2.36216420
56Lethargy (HP:0001254)2.35195544
57Increased muscle lipid content (HP:0009058)2.33163292
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32081137
59Medial flaring of the eyebrow (HP:0010747)2.31709170
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30496767
61Dicarboxylic aciduria (HP:0003215)2.30496767
62Abnormality of cells of the erythroid lineage (HP:0012130)2.27886818
63Renal cortical cysts (HP:0000803)2.26372788
64Abnormality of serine family amino acid metabolism (HP:0010894)2.24400757
65Abnormality of glycine metabolism (HP:0010895)2.24400757
66Hyperglycinuria (HP:0003108)2.22482793
67Dry hair (HP:0011359)2.20759432
68Exertional dyspnea (HP:0002875)2.20245345
69Abnormality of the labia minora (HP:0012880)2.19387202
70Absent/shortened dynein arms (HP:0200106)2.18863396
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.18863396
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14565526
73Abnormal protein N-linked glycosylation (HP:0012347)2.14565526
74Abnormal protein glycosylation (HP:0012346)2.14565526
75Abnormal glycosylation (HP:0012345)2.14565526
76Myokymia (HP:0002411)2.13626162
77Methylmalonic aciduria (HP:0012120)2.13591526
78Aplasia/hypoplasia of the uterus (HP:0008684)2.13345709
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12912048
80Patchy hypopigmentation of hair (HP:0011365)2.12526117
81Retinal dysplasia (HP:0007973)2.11232420
82Nephronophthisis (HP:0000090)2.10765541
83CNS demyelination (HP:0007305)2.10663019
84Abnormal pupillary function (HP:0007686)2.09782899
85Ketoacidosis (HP:0001993)2.07451511
86Vacuolated lymphocytes (HP:0001922)2.07320035
87Septo-optic dysplasia (HP:0100842)2.06050996
88Upper limb muscle weakness (HP:0003484)2.05414573
89Progressive external ophthalmoplegia (HP:0000590)2.05080319
90Abnormality of urine glucose concentration (HP:0011016)2.04823793
91Glycosuria (HP:0003076)2.04823793
92Hepatosplenomegaly (HP:0001433)2.04636226
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.03868813
94Hypoplasia of the fovea (HP:0007750)2.03868813
95Delayed CNS myelination (HP:0002188)2.03671968
96Congenital sensorineural hearing impairment (HP:0008527)2.03587553
97Duplication of thumb phalanx (HP:0009942)2.02243039
98Methylmalonic acidemia (HP:0002912)2.01236378
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97949250
100Generalized aminoaciduria (HP:0002909)1.97573894
101Sclerocornea (HP:0000647)1.97527099
102White forelock (HP:0002211)1.95851622
103Pancytopenia (HP:0001876)1.95184320
104Spastic paraparesis (HP:0002313)1.93175426
105Abnormality of secondary sexual hair (HP:0009888)1.92658855
106Abnormality of the axillary hair (HP:0100134)1.92658855
107X-linked dominant inheritance (HP:0001423)1.92219387
108Ketosis (HP:0001946)1.92078064
109Respiratory difficulties (HP:0002880)1.91235203
110Abnormality of serum amino acid levels (HP:0003112)1.89497250
111Megaloblastic anemia (HP:0001889)1.89276623
112Type I transferrin isoform profile (HP:0003642)1.89144155
113Abnormality of placental membranes (HP:0011409)1.88997954
114Amniotic constriction ring (HP:0009775)1.88997954
115CNS hypomyelination (HP:0003429)1.86947912
116Abnormality of the septum pellucidum (HP:0007375)1.86842868
117Absent septum pellucidum (HP:0001331)1.86439451
118Nephrogenic diabetes insipidus (HP:0009806)1.84359029
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.83446603
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83446603
121Adrenal hypoplasia (HP:0000835)1.82948995
122Congenital primary aphakia (HP:0007707)1.82391556
123Anencephaly (HP:0002323)1.82147745
124Cerebellar dysplasia (HP:0007033)1.81549469
125Abnormal number of erythroid precursors (HP:0012131)1.80779975
126Seborrheic dermatitis (HP:0001051)1.80559471
127Metabolic acidosis (HP:0001942)1.80539187
128Partial duplication of thumb phalanx (HP:0009944)1.80363172
129Gait imbalance (HP:0002141)1.79961175
130Rhinitis (HP:0012384)1.79017346
131Hypophosphatemic rickets (HP:0004912)1.78672789
132Emotional lability (HP:0000712)1.78592965
133Bronchiectasis (HP:0002110)1.78462469
134Hyperglycinemia (HP:0002154)1.75075048
135Abnormal ciliary motility (HP:0012262)1.75034261
136Neutropenia (HP:0001875)1.74780517
137Birth length less than 3rd percentile (HP:0003561)1.74720650
138Type II lissencephaly (HP:0007260)1.74451211
139Aplastic anemia (HP:0001915)1.74413993
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.74361072
141Pallor (HP:0000980)1.74305061
142Abnormality of the fovea (HP:0000493)1.74277462
143Abnormal rod and cone electroretinograms (HP:0008323)1.74169893
144Stomach cancer (HP:0012126)1.72964165
145Nasolacrimal duct obstruction (HP:0000579)1.72649961
146Reduced antithrombin III activity (HP:0001976)1.72537593
147Short tibia (HP:0005736)1.72481372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.62994827
2VRK23.73300066
3CASK3.60945530
4BUB13.38927745
5TRIM283.25271958
6NME23.01640111
7EPHB12.88592719
8INSRR2.63909963
9STK392.57486128
10PIK3CG2.47029967
11IRAK32.39977000
12PBK2.38547989
13TLK12.21138500
14EIF2AK12.11435705
15ZAK2.07319724
16NME11.99951716
17OXSR11.90918604
18MAP4K21.88229636
19MST41.79112328
20BCKDK1.77525278
21WNK31.71119029
22BLK1.69606725
23MKNK21.68927042
24EIF2AK21.65739729
25VRK11.63565187
26TNIK1.62715068
27EIF2AK31.61446052
28FRK1.59903509
29GRK71.58706167
30GRK11.56909891
31MKNK11.52094082
32PKN11.44913499
33TESK21.43192547
34EPHA21.42297484
35SRPK11.41712924
36MAPKAPK31.27493812
37IRAK41.25933921
38WEE11.24743070
39MUSK1.19530259
40TTK1.14491602
41STK38L1.14409610
42PIM21.13653092
43DAPK11.12811818
44NEK61.12150377
45PHKG21.11326374
46PHKG11.11326374
47CSNK1G21.09434672
48IRAK21.09307546
49CLK11.08389135
50CSNK1G11.07190409
51CDC71.07132840
52BMPR1B1.05687239
53IRAK11.05532773
54PLK41.05191365
55NEK11.03963522
56ADRBK21.01131048
57TXK1.00704235
58BRAF0.99917623
59PNCK0.99186542
60ACVR1B0.99051932
61PLK20.98950190
62BCR0.97828000
63ARAF0.92801886
64MAP3K140.92633617
65BMPR20.91857400
66TAF10.86939971
67DYRK20.86789406
68PRKCG0.85931100
69PIK3CA0.83889917
70PDK20.83837343
71YES10.83551098
72TGFBR10.75956592
73CAMK2B0.75156380
74WNK40.74980833
75ADRBK10.74287653
76AKT30.72134586
77GRK50.70217979
78ABL20.70179429
79MAP3K30.68735951
80CAMKK20.68035125
81DAPK30.67325085
82CDK30.65667389
83FLT30.65331943
84MAP3K120.65160505
85PLK10.63491959
86PRKCI0.63279303
87MAP2K60.63033768
88RPS6KA50.62466718
89PINK10.61304061
90MAPKAPK50.60967031
91CDK80.60704564
92MST1R0.60662573
93AURKA0.56434579
94DYRK30.56311143
95ERBB30.55827671
96ATR0.55666213
97MET0.54682487
98MAP3K110.54558089
99BRSK10.54296153
100CAMK2G0.54287416
101CSNK2A10.54089820
102CSNK1G30.52632898
103CHEK20.52477322
104CDK190.52152048
105TEC0.51877507
106KIT0.51587080
107MAP3K40.50302424
108PRKCE0.50207324
109CAMK2D0.49782133
110DMPK0.49051929
111PAK10.48959762
112MAPK150.48508124
113MAP2K70.48339959
114BRSK20.47132119
115IKBKB0.46779612
116AURKB0.46100859
117CSNK1A10.45885622
118MAP2K20.45511965
119ROCK20.44891617
120PAK30.44214299
121CSNK2A20.42362417
122CAMK2A0.42047145
123PLK30.41121337
124CCNB10.40970298
125MYLK0.40646318
126CSNK1A1L0.40512106
127LIMK10.38984537
128TSSK60.38806377
129MINK10.38312351
130MAPK130.37712178
131KDR0.37490708
132MAP3K130.37329786
133NUAK10.35725945
134PRKCQ0.35587664
135MAP2K30.34756518
136MARK30.34749828
137TIE10.33808076
138ILK0.33465286
139FGR0.32806711
140LYN0.31429567
141OBSCN0.31100436
142MOS0.30079879
143PRKG10.29946226
144PRKACA0.29475744

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.74748268
2Ribosome_Homo sapiens_hsa030103.50134622
3Proteasome_Homo sapiens_hsa030503.33351258
4Fatty acid elongation_Homo sapiens_hsa000623.03945821
5RNA polymerase_Homo sapiens_hsa030202.96428669
6Parkinsons disease_Homo sapiens_hsa050122.92227950
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87256895
8Protein export_Homo sapiens_hsa030602.50325862
9Vitamin B6 metabolism_Homo sapiens_hsa007502.37055035
10Steroid biosynthesis_Homo sapiens_hsa001002.25003771
11Huntingtons disease_Homo sapiens_hsa050162.18512022
12Alzheimers disease_Homo sapiens_hsa050102.18508155
13Homologous recombination_Homo sapiens_hsa034402.12972210
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99881994
15Pyrimidine metabolism_Homo sapiens_hsa002401.94466861
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90822486
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90519779
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79721319
19Mismatch repair_Homo sapiens_hsa034301.69341179
20DNA replication_Homo sapiens_hsa030301.65790352
21Propanoate metabolism_Homo sapiens_hsa006401.65751867
22Folate biosynthesis_Homo sapiens_hsa007901.63366936
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60295265
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55700667
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54725250
26Nucleotide excision repair_Homo sapiens_hsa034201.50558525
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49501714
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47224495
29Fanconi anemia pathway_Homo sapiens_hsa034601.46575239
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45980548
31Arachidonic acid metabolism_Homo sapiens_hsa005901.43025042
32Sulfur metabolism_Homo sapiens_hsa009201.36942758
33Basal transcription factors_Homo sapiens_hsa030221.35355227
34Sphingolipid metabolism_Homo sapiens_hsa006001.34456288
35Histidine metabolism_Homo sapiens_hsa003401.33482185
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27208403
37Ether lipid metabolism_Homo sapiens_hsa005651.27099196
38Purine metabolism_Homo sapiens_hsa002301.25019457
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24977298
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19079401
41Glutathione metabolism_Homo sapiens_hsa004801.14932249
42Caffeine metabolism_Homo sapiens_hsa002321.14094880
43Vitamin digestion and absorption_Homo sapiens_hsa049771.13144981
44Linoleic acid metabolism_Homo sapiens_hsa005911.12129116
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08583776
46Peroxisome_Homo sapiens_hsa041461.08088157
47beta-Alanine metabolism_Homo sapiens_hsa004101.07500040
48Metabolic pathways_Homo sapiens_hsa011001.06110711
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05371776
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02293561
51Retinol metabolism_Homo sapiens_hsa008301.00046185
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00027219
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99237772
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98404777
55Nitrogen metabolism_Homo sapiens_hsa009100.97767074
56Arginine and proline metabolism_Homo sapiens_hsa003300.96938879
57Fatty acid metabolism_Homo sapiens_hsa012120.95863124
58One carbon pool by folate_Homo sapiens_hsa006700.94616198
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94214844
60Spliceosome_Homo sapiens_hsa030400.92469370
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.91877670
62Non-homologous end-joining_Homo sapiens_hsa034500.89627830
63Pyruvate metabolism_Homo sapiens_hsa006200.86677567
64Autoimmune thyroid disease_Homo sapiens_hsa053200.86291871
65Selenocompound metabolism_Homo sapiens_hsa004500.84944586
66Butanoate metabolism_Homo sapiens_hsa006500.83476980
67Tyrosine metabolism_Homo sapiens_hsa003500.81586610
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79481081
69Base excision repair_Homo sapiens_hsa034100.78187393
70Chemical carcinogenesis_Homo sapiens_hsa052040.73414909
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.72437450
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71211171
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69470328
74Fatty acid degradation_Homo sapiens_hsa000710.68263009
75Cardiac muscle contraction_Homo sapiens_hsa042600.67239699
76Mineral absorption_Homo sapiens_hsa049780.67182041
77Phototransduction_Homo sapiens_hsa047440.66883346
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.63647063
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.61520226
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61400182
81Collecting duct acid secretion_Homo sapiens_hsa049660.58127017
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.55858344
83Arginine biosynthesis_Homo sapiens_hsa002200.55544465
84Carbon metabolism_Homo sapiens_hsa012000.51601833
85Phenylalanine metabolism_Homo sapiens_hsa003600.51574558
86Rheumatoid arthritis_Homo sapiens_hsa053230.49376996
87Biosynthesis of amino acids_Homo sapiens_hsa012300.48847344
88PPAR signaling pathway_Homo sapiens_hsa033200.45769751
89Other glycan degradation_Homo sapiens_hsa005110.44996069
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44691080
91Glycerolipid metabolism_Homo sapiens_hsa005610.43816822
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.42422728
93Galactose metabolism_Homo sapiens_hsa000520.41812477
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41681867
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.41383430
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38776778
97Regulation of autophagy_Homo sapiens_hsa041400.38754929
98Synaptic vesicle cycle_Homo sapiens_hsa047210.38476931
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38301620
100RNA transport_Homo sapiens_hsa030130.37858998
101Pentose phosphate pathway_Homo sapiens_hsa000300.36343873
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35560183
103Starch and sucrose metabolism_Homo sapiens_hsa005000.34913406
104RNA degradation_Homo sapiens_hsa030180.34729692
105Sulfur relay system_Homo sapiens_hsa041220.34669165
106Fat digestion and absorption_Homo sapiens_hsa049750.27878875
107Vibrio cholerae infection_Homo sapiens_hsa051100.26561656
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25552312
109Lysosome_Homo sapiens_hsa041420.25541112
110Allograft rejection_Homo sapiens_hsa053300.24986932
111Fructose and mannose metabolism_Homo sapiens_hsa000510.24694520
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.22262239
113Tryptophan metabolism_Homo sapiens_hsa003800.21819049
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20706679
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19031318
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18832637
117Systemic lupus erythematosus_Homo sapiens_hsa053220.14490017

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