DHTKD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.19116982
2omega-hydroxylase P450 pathway (GO:0097267)6.40452020
3epoxygenase P450 pathway (GO:0019373)5.74482771
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.60739806
5mitotic metaphase plate congression (GO:0007080)5.45888046
6oxidative demethylation (GO:0070989)5.39184440
7serine family amino acid catabolic process (GO:0009071)5.38238798
8monoubiquitinated protein deubiquitination (GO:0035520)5.13462871
9cellular glucuronidation (GO:0052695)5.04942712
10drug metabolic process (GO:0017144)4.99169813
11L-phenylalanine catabolic process (GO:0006559)4.94078087
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.94078087
13uronic acid metabolic process (GO:0006063)4.91324997
14glucuronate metabolic process (GO:0019585)4.91324997
15regulation of transcription from RNA polymerase I promoter (GO:0006356)4.81918377
16L-serine metabolic process (GO:0006563)4.81332428
17aromatic amino acid family catabolic process (GO:0009074)4.81017001
18regulation of establishment of cell polarity (GO:2000114)4.80001307
19urea cycle (GO:0000050)4.63830362
20urea metabolic process (GO:0019627)4.63830362
21regulation of bile acid biosynthetic process (GO:0070857)4.63653534
22tryptophan catabolic process (GO:0006569)4.62084044
23indole-containing compound catabolic process (GO:0042436)4.62084044
24indolalkylamine catabolic process (GO:0046218)4.62084044
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.46365577
26L-phenylalanine metabolic process (GO:0006558)4.46365577
27tryptophan metabolic process (GO:0006568)4.38535493
28biotin metabolic process (GO:0006768)4.37634123
29ethanol oxidation (GO:0006069)4.21361935
30nitrogen cycle metabolic process (GO:0071941)4.21078848
31phenylpropanoid metabolic process (GO:0009698)4.19842683
32glycine metabolic process (GO:0006544)4.19498145
33regulation of retinoic acid receptor signaling pathway (GO:0048385)4.18533516
34regulation of establishment or maintenance of cell polarity (GO:0032878)4.13353942
35vitamin transmembrane transport (GO:0035461)4.12633258
36cysteine metabolic process (GO:0006534)4.10770317
37kynurenine metabolic process (GO:0070189)4.08486013
38regulation of meiosis I (GO:0060631)4.05829479
39metaphase plate congression (GO:0051310)4.03140714
40urate metabolic process (GO:0046415)3.95950243
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95450077
42snRNA transcription (GO:0009301)3.93832876
43bile acid biosynthetic process (GO:0006699)3.91609628
44bile acid and bile salt transport (GO:0015721)3.90584833
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.81173922
46male meiosis I (GO:0007141)3.80839544
47homocysteine metabolic process (GO:0050667)3.78179138
48meiosis I (GO:0007127)3.77634510
49regulation of spindle organization (GO:0090224)3.77576467
50heme transport (GO:0015886)3.76431070
51serine family amino acid metabolic process (GO:0009069)3.74559080
52DNA damage response, signal transduction resulting in transcription (GO:0042772)3.72430940
53L-methionine salvage (GO:0071267)3.70233210
54L-methionine biosynthetic process (GO:0071265)3.70233210
55amino acid salvage (GO:0043102)3.70233210
56alkaloid metabolic process (GO:0009820)3.69953449
57pyrimidine nucleobase catabolic process (GO:0006208)3.64246246
58aromatic amino acid family metabolic process (GO:0009072)3.63336645
59folic acid metabolic process (GO:0046655)3.62614608
60negative regulation of keratinocyte proliferation (GO:0010839)3.61117788
61flavonoid metabolic process (GO:0009812)3.60663313
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60630908
63ethanol metabolic process (GO:0006067)3.60499601
64meiotic chromosome segregation (GO:0045132)3.56983983
65bile acid metabolic process (GO:0008206)3.56608795
66microtubule depolymerization (GO:0007019)3.56349608
67oocyte maturation (GO:0001556)3.55417727
68negative regulation of cholesterol transport (GO:0032375)3.54490394
69negative regulation of sterol transport (GO:0032372)3.54490394
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.51678767
71acylglycerol homeostasis (GO:0055090)3.51418354
72triglyceride homeostasis (GO:0070328)3.51418354
73lens morphogenesis in camera-type eye (GO:0002089)3.51065298
74regulation of exit from mitosis (GO:0007096)3.50049137
75regulation of protein activation cascade (GO:2000257)3.49818367
76regulation of fibrinolysis (GO:0051917)3.49345035
77lysine metabolic process (GO:0006553)3.47980403
78lysine catabolic process (GO:0006554)3.47980403
79protein K6-linked ubiquitination (GO:0085020)3.47619137
80negative regulation of fibrinolysis (GO:0051918)3.41943291
81amino-acid betaine metabolic process (GO:0006577)3.41113589
82pyrimidine-containing compound transmembrane transport (GO:0072531)3.40895715
83amine catabolic process (GO:0009310)3.39601199
84cellular biogenic amine catabolic process (GO:0042402)3.39601199
85pentose metabolic process (GO:0019321)3.39566017
86DNA replication checkpoint (GO:0000076)3.39402628
87serine family amino acid biosynthetic process (GO:0009070)3.39228690
88high-density lipoprotein particle remodeling (GO:0034375)3.38803301
89complement activation, alternative pathway (GO:0006957)3.33868784
90S-adenosylmethionine metabolic process (GO:0046500)3.33577666
91aspartate family amino acid catabolic process (GO:0009068)3.33552670
92tyrosine metabolic process (GO:0006570)3.32540984
93cellular ketone body metabolic process (GO:0046950)3.31845821
94alpha-amino acid catabolic process (GO:1901606)3.31719418
95glyoxylate metabolic process (GO:0046487)3.31070356
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.30206389
97indolalkylamine metabolic process (GO:0006586)3.29575230
98inner cell mass cell proliferation (GO:0001833)3.29248400
99negative regulation of fatty acid biosynthetic process (GO:0045717)3.22733387
100regulation of complement activation (GO:0030449)3.22687826
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21620595
102sulfur amino acid catabolic process (GO:0000098)3.21274351
103drug catabolic process (GO:0042737)3.19639658
104resolution of meiotic recombination intermediates (GO:0000712)3.18289802
105sulfur amino acid biosynthetic process (GO:0000097)3.16244492
106ketone body metabolic process (GO:1902224)3.15257991
107female gonad development (GO:0008585)3.14550225
108purine nucleobase biosynthetic process (GO:0009113)3.14159631
109arginine metabolic process (GO:0006525)3.12128740
110negative regulation of cell aging (GO:0090344)3.11222780
111protein carboxylation (GO:0018214)3.10496402
112peptidyl-glutamic acid carboxylation (GO:0017187)3.10496402
113tetrahydrofolate metabolic process (GO:0046653)3.09283338
114blood coagulation, intrinsic pathway (GO:0007597)3.08296159
115regulation of RNA export from nucleus (GO:0046831)3.05558832
116methionine biosynthetic process (GO:0009086)3.02949115
117regulation of cholesterol esterification (GO:0010872)3.00918619
118acetyl-CoA metabolic process (GO:0006084)2.99014142
119establishment of chromosome localization (GO:0051303)2.98087154
120nucleobase catabolic process (GO:0046113)2.98063085
121carnitine metabolic process (GO:0009437)2.97575674
122linoleic acid metabolic process (GO:0043651)2.97318299
123response to hydroperoxide (GO:0033194)2.97051281
124protein localization to chromosome, centromeric region (GO:0071459)2.95258148
125aldehyde catabolic process (GO:0046185)2.92517679
126regulation of triglyceride catabolic process (GO:0010896)2.92508779
127sister chromatid cohesion (GO:0007062)2.91235563
128positive regulation of chromosome segregation (GO:0051984)2.90608971
129carboxylic acid catabolic process (GO:0046395)2.90181883
130organic acid catabolic process (GO:0016054)2.90181883
131cellular amino acid catabolic process (GO:0009063)2.90036000
132plasma lipoprotein particle remodeling (GO:0034369)2.89989643
133protein-lipid complex remodeling (GO:0034368)2.89989643
134macromolecular complex remodeling (GO:0034367)2.89989643
135methionine metabolic process (GO:0006555)2.89534115
136imidazole-containing compound metabolic process (GO:0052803)2.88511248
137protein localization to kinetochore (GO:0034501)2.88087943
138regulation of posttranscriptional gene silencing (GO:0060147)2.86385565
139regulation of gene silencing by miRNA (GO:0060964)2.86385565
140regulation of gene silencing by RNA (GO:0060966)2.86385565
141aspartate family amino acid metabolic process (GO:0009066)2.81695215
142branched-chain amino acid catabolic process (GO:0009083)2.81295206
143fibrinolysis (GO:0042730)2.81291710
1442-oxoglutarate metabolic process (GO:0006103)2.79046176
145behavioral response to nicotine (GO:0035095)2.76962167
146negative regulation of lipase activity (GO:0060192)2.74835333
147glutamine family amino acid metabolic process (GO:0009064)2.72671082
148xenobiotic metabolic process (GO:0006805)2.71508863
149coenzyme catabolic process (GO:0009109)2.70960455
150branched-chain amino acid metabolic process (GO:0009081)2.69713546
151glutamate metabolic process (GO:0006536)2.68184856
152primary alcohol catabolic process (GO:0034310)2.65355365
153intestinal cholesterol absorption (GO:0030299)2.63018550
154fatty acid transmembrane transport (GO:1902001)2.62562735
155alpha-amino acid metabolic process (GO:1901605)2.61520458
156monocarboxylic acid catabolic process (GO:0072329)2.59811793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.02999122
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.90366366
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80789355
4KAP1_22055183_ChIP-Seq_ESCs_Mouse4.34193096
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.11769190
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.85600014
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.43271880
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.09143586
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.03196839
10E2F7_22180533_ChIP-Seq_HELA_Human2.96156149
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83203192
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.78645734
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52325301
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.48345356
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.48018225
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47716193
17ZNF274_21170338_ChIP-Seq_K562_Hela2.30090628
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.28981212
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.27479449
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.26223943
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23531239
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16618576
23AR_21909140_ChIP-Seq_LNCAP_Human2.10355432
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04209060
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01356091
26IRF1_19129219_ChIP-ChIP_H3396_Human1.92667961
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88198462
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84637916
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84295191
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79449875
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78164859
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73660751
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73156481
34ER_23166858_ChIP-Seq_MCF-7_Human1.71827798
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65772242
36GBX2_23144817_ChIP-Seq_PC3_Human1.64638395
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62161150
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.55425096
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.52035354
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50128140
41ELK1_19687146_ChIP-ChIP_HELA_Human1.47078374
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46734059
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45944896
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.44485355
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43574693
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43292162
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41196826
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41147860
49VDR_22108803_ChIP-Seq_LS180_Human1.36720320
50EWS_26573619_Chip-Seq_HEK293_Human1.36424595
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.34181967
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33994857
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33994857
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.33372838
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.33278054
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30890322
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30473421
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30147133
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.29282301
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29229889
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27895075
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27600184
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.27581822
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26425373
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26395245
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26100467
67IGF1R_20145208_ChIP-Seq_DFB_Human1.26096345
68STAT1_17558387_ChIP-Seq_HELA_Human1.25489863
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23462846
70RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21949780
71HTT_18923047_ChIP-ChIP_STHdh_Human1.20799411
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18823503
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17264053
74HOXB7_26014856_ChIP-Seq_BT474_Human1.16353417
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14613825
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10252107
77TBL1_22424771_ChIP-Seq_293T_Human1.08051238
78P300_19829295_ChIP-Seq_ESCs_Human1.07725594
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07440449
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07414309
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07115236
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.06921144
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06494974
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.06289787
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05697075
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05585053
87CBP_20019798_ChIP-Seq_JUKART_Human1.05160933
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05160933
89HNF4A_19822575_ChIP-Seq_HepG2_Human1.04949696
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04543093
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00987878
92FOXP3_21729870_ChIP-Seq_TREG_Human1.00130380
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00023570
94* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99188256
95TCF4_23295773_ChIP-Seq_U87_Human0.98527185
96* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98424880
97* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98424880
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98299681
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.98254172
100HNFA_21074721_ChIP-Seq_CACO-2_Human0.98125589
101SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97760389
102* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97513876
103CRX_20693478_ChIP-Seq_RETINA_Mouse0.96805516
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.96066936
105SOX2_18555785_Chip-Seq_ESCs_Mouse0.95647679
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95557197
107AR_21572438_ChIP-Seq_LNCaP_Human0.95523142
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95093697
109NMYC_18555785_Chip-Seq_ESCs_Mouse0.95028774
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94283226
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94053200
112FUS_26573619_Chip-Seq_HEK293_Human0.92815826
113NFYA_21822215_ChIP-Seq_K562_Human0.92726440
114P53_22387025_ChIP-Seq_ESCs_Mouse0.92367321
115STAT3_23295773_ChIP-Seq_U87_Human0.92302329
116ZFX_18555785_Chip-Seq_ESCs_Mouse0.91880137
117KAP1_27257070_Chip-Seq_ESCs_Mouse0.91302387
118CDX2_22108803_ChIP-Seq_LS180_Human0.91067504
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90972201
120PHF8_20622853_ChIP-Seq_HELA_Human0.90492839
121* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89870195
122GATA6_21074721_ChIP-Seq_CACO-2_Human0.89398892
123TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88718553
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88656176
125ETV1_20927104_ChIP-Seq_GIST48_Human0.88495299
126OCT4_18555785_Chip-Seq_ESCs_Mouse0.88295902
127AR_20517297_ChIP-Seq_VCAP_Human0.88009337
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87724846
129BCAT_22108803_ChIP-Seq_LS180_Human0.87564678
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87217466
131CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86999867
132RNF2_27304074_Chip-Seq_NSC_Mouse0.86439638
133STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85920903
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85129709
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.84546134
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84462374
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84413595
138NCOR_22424771_ChIP-Seq_293T_Human0.84204225
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84159810
140MYC_18940864_ChIP-ChIP_HL60_Human0.84111743
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.84038035
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83687170
143TAF15_26573619_Chip-Seq_HEK293_Human0.83309278
144CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82798242
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82639788
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.82437116
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82189289
148KLF4_18555785_Chip-Seq_ESCs_Mouse0.82082159
149MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81864775
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.80981058
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80732032
152* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80295920
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.80256888
154ESRRB_18555785_Chip-Seq_ESCs_Mouse0.79607383
155NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78866941
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78411584
157NFYB_21822215_ChIP-Seq_K562_Human0.78177033
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77706069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.93312120
2MP0005360_urolithiasis5.38958935
3MP0005365_abnormal_bile_salt5.06575200
4MP0005085_abnormal_gallbladder_physiolo4.62591460
5MP0005451_abnormal_body_composition4.42848450
6MP0008875_abnormal_xenobiotic_pharmacok3.48186889
7MP0006292_abnormal_olfactory_placode3.22565002
8MP0003718_maternal_effect2.93580813
9MP0002254_reproductive_system_inflammat2.74282373
10MP0003693_abnormal_embryo_hatching2.65950546
11MP0003252_abnormal_bile_duct2.59245373
12MP0008057_abnormal_DNA_replication2.56993765
13MP0000566_synostosis2.50813817
14MP0005408_hypopigmentation2.36975119
15MP0005647_abnormal_sex_gland2.36528682
16MP0002837_dystrophic_cardiac_calcinosis2.35334692
17MP0008007_abnormal_cellular_replicative2.19413308
18MP0009840_abnormal_foam_cell2.11787464
19MP0003806_abnormal_nucleotide_metabolis2.11437474
20MP0003111_abnormal_nucleus_morphology2.11175981
21MP0002102_abnormal_ear_morphology2.09649532
22MP0010329_abnormal_lipoprotein_level2.01871736
23MP0003077_abnormal_cell_cycle1.90185009
24MP0005332_abnormal_amino_acid1.86097864
25MP0003868_abnormal_feces_composition1.85783740
26MP0004019_abnormal_vitamin_homeostasis1.73935001
27MP0002876_abnormal_thyroid_physiology1.68355290
28MP0008058_abnormal_DNA_repair1.66531065
29MP0010094_abnormal_chromosome_stability1.63401453
30MP0008877_abnormal_DNA_methylation1.62011676
31MP0000609_abnormal_liver_physiology1.56638839
32MP0003195_calcinosis1.50903857
33MP0005395_other_phenotype1.49767284
34MP0001661_extended_life_span1.48756780
35MP0002653_abnormal_ependyma_morphology1.43619307
36MP0002138_abnormal_hepatobiliary_system1.41891068
37MP0010307_abnormal_tumor_latency1.30932610
38MP0001119_abnormal_female_reproductive1.28336265
39MP0003937_abnormal_limbs/digits/tail_de1.26481387
40MP0001929_abnormal_gametogenesis1.24422890
41MP0000579_abnormal_nail_morphology1.23805338
42MP0003699_abnormal_female_reproductive1.21791700
43MP0001764_abnormal_homeostasis1.20764892
44MP0001666_abnormal_nutrient_absorption1.20631757
45MP0002751_abnormal_autonomic_nervous1.20220509
46MP0001293_anophthalmia1.20054703
47MP0010030_abnormal_orbit_morphology1.18975822
48MP0002210_abnormal_sex_determination1.18830108
49MP0000569_abnormal_digit_pigmentation1.17712743
50MP0002118_abnormal_lipid_homeostasis1.17621790
51MP0003136_yellow_coat_color1.17244353
52MP0004233_abnormal_muscle_weight1.15193923
53MP0005377_hearing/vestibular/ear_phenot1.13050298
54MP0003878_abnormal_ear_physiology1.13050298
55MP0000653_abnormal_sex_gland1.12988953
56MP0004957_abnormal_blastocyst_morpholog1.12921620
57MP0003011_delayed_dark_adaptation1.12774123
58MP0002282_abnormal_trachea_morphology1.09181896
59MP0009053_abnormal_anal_canal1.07124090
60MP0001730_embryonic_growth_arrest1.06131022
61MP0002938_white_spotting1.06049737
62MP0009672_abnormal_birth_weight1.05687336
63MP0004381_abnormal_hair_follicle1.04752203
64MP0004185_abnormal_adipocyte_glucose1.04611014
65MP0008995_early_reproductive_senescence1.03623128
66MP0004043_abnormal_pH_regulation1.03186779
67MP0001529_abnormal_vocalization1.02455787
68MP0000639_abnormal_adrenal_gland1.00414042
69MP0005551_abnormal_eye_electrophysiolog1.00398329
70MP0005248_abnormal_Harderian_gland0.99708278
71MP0009697_abnormal_copulation0.98902818
72MP0001145_abnormal_male_reproductive0.97937747
73MP0002697_abnormal_eye_size0.97214857
74MP0005220_abnormal_exocrine_pancreas0.96013203
75MP0008260_abnormal_autophagy0.93212065
76MP0005083_abnormal_biliary_tract0.93102585
77MP0001672_abnormal_embryogenesis/_devel0.90137286
78MP0005380_embryogenesis_phenotype0.90137286
79MP0004133_heterotaxia0.89987859
80MP0006072_abnormal_retinal_apoptosis0.88967400
81MP0008872_abnormal_physiological_respon0.87374474
82MP0003938_abnormal_ear_development0.86071401
83MP0008932_abnormal_embryonic_tissue0.84382257
84MP0005646_abnormal_pituitary_gland0.83872313
85MP0006035_abnormal_mitochondrial_morpho0.83576079
86MP0000350_abnormal_cell_proliferation0.83059305
87MP0000647_abnormal_sebaceous_gland0.82639762
88MP0000631_abnormal_neuroendocrine_gland0.82559414
89MP0003656_abnormal_erythrocyte_physiolo0.81765616
90MP0005379_endocrine/exocrine_gland_phen0.81636109
91MP0002132_abnormal_respiratory_system0.80361702
92MP0003567_abnormal_fetal_cardiomyocyte0.78815692
93MP0005171_absent_coat_pigmentation0.78021577
94MP0002098_abnormal_vibrissa_morphology0.77899962
95MP0004264_abnormal_extraembryonic_tissu0.77886020
96MP0001919_abnormal_reproductive_system0.76391856
97MP0005266_abnormal_metabolism0.75659813
98MP0001286_abnormal_eye_development0.74543945
99MP0002277_abnormal_respiratory_mucosa0.74469880
100MP0005197_abnormal_uvea_morphology0.74133236
101MP0002249_abnormal_larynx_morphology0.73947495
102MP0003941_abnormal_skin_development0.72435735
103MP0002928_abnormal_bile_duct0.72314728
104MP0005319_abnormal_enzyme/_coenzyme0.72228419
105MP0003646_muscle_fatigue0.71194686
106MP0009333_abnormal_splenocyte_physiolog0.70984897
107MP0003698_abnormal_male_reproductive0.69829911
108MP0002009_preneoplasia0.69667875
109MP0005389_reproductive_system_phenotype0.69095158
110MP0002161_abnormal_fertility/fecundity0.68010979
111MP0005084_abnormal_gallbladder_morpholo0.66405087
112MP0002234_abnormal_pharynx_morphology0.66367052
113MP0000627_abnormal_mammary_gland0.65793532
114MP0004130_abnormal_muscle_cell0.65748211
115MP0003890_abnormal_embryonic-extraembry0.65446639
116MP0008789_abnormal_olfactory_epithelium0.65258480
117MP0002163_abnormal_gland_morphology0.64920375
118MP0001324_abnormal_eye_pigmentation0.64697857
119MP0004145_abnormal_muscle_electrophysio0.63798786
120MP0000598_abnormal_liver_morphology0.63733476
121MP0002160_abnormal_reproductive_system0.63592274
122MP0005075_abnormal_melanosome_morpholog0.63018367
123MP0002085_abnormal_embryonic_tissue0.62563531
124MP0003943_abnormal_hepatobiliary_system0.62157330
125MP0003984_embryonic_growth_retardation0.61014730
126MP0005670_abnormal_white_adipose0.59280800
127MP0001881_abnormal_mammary_gland0.59197216
128MP0005253_abnormal_eye_physiology0.59159491
129MP0000427_abnormal_hair_cycle0.58176832
130MP0002088_abnormal_embryonic_growth/wei0.58141463
131MP0002269_muscular_atrophy0.57722270
132MP0009764_decreased_sensitivity_to0.57278219
133MP0002084_abnormal_developmental_patter0.56932823
134MP0005187_abnormal_penis_morphology0.56704253
135MP0002233_abnormal_nose_morphology0.55629893
136MP0003191_abnormal_cellular_cholesterol0.54671275
137MP0003119_abnormal_digestive_system0.54384488
138MP0003861_abnormal_nervous_system0.54126213
139MP0000538_abnormal_urinary_bladder0.54005913
140MP0000462_abnormal_digestive_system0.53880575
141MP0005636_abnormal_mineral_homeostasis0.52143515
142MP0002086_abnormal_extraembryonic_tissu0.52094892
143MP0000383_abnormal_hair_follicle0.51938764
144MP0002971_abnormal_brown_adipose0.50994486
145MP0001346_abnormal_lacrimal_gland0.50875130
146MP0002396_abnormal_hematopoietic_system0.50856034

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)5.19213996
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.90228435
3Intrahepatic cholestasis (HP:0001406)4.79588482
4Hyperglycinemia (HP:0002154)4.78816031
5Prostate neoplasm (HP:0100787)4.67198652
6Capillary hemangiomas (HP:0005306)4.63209771
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.43835451
8Spontaneous abortion (HP:0005268)4.38273906
9Deep venous thrombosis (HP:0002625)4.37690748
10Chromsome breakage (HP:0040012)4.36070809
11Prolonged partial thromboplastin time (HP:0003645)4.35974474
12Hyperglycinuria (HP:0003108)4.21061665
13Sensorimotor neuropathy (HP:0007141)4.09752915
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.95673754
15Birth length less than 3rd percentile (HP:0003561)3.84657008
16Azoospermia (HP:0000027)3.75079149
17Hypobetalipoproteinemia (HP:0003563)3.60368473
18Abnormality of glycine metabolism (HP:0010895)3.57868120
19Abnormality of serine family amino acid metabolism (HP:0010894)3.57868120
20Xanthomatosis (HP:0000991)3.44599207
21Joint hemorrhage (HP:0005261)3.38968711
22Myocardial infarction (HP:0001658)3.36878435
23Papillary thyroid carcinoma (HP:0002895)3.20794506
24Bile duct proliferation (HP:0001408)3.19490477
25Abnormal biliary tract physiology (HP:0012439)3.19490477
26Impulsivity (HP:0100710)3.18650315
27Complement deficiency (HP:0004431)3.13511376
28Hyperlipoproteinemia (HP:0010980)3.10999921
29Gout (HP:0001997)3.05663485
30Hypolipoproteinemia (HP:0010981)2.98962281
31Abnormal spermatogenesis (HP:0008669)2.98936418
32Hypoalphalipoproteinemia (HP:0003233)2.98372752
33Epidermoid cyst (HP:0200040)2.97810602
34Breast hypoplasia (HP:0003187)2.91875254
35Abnormality of lateral ventricle (HP:0030047)2.90489501
36Abnormality of the labia minora (HP:0012880)2.89749999
37Abnormality of the intrinsic pathway (HP:0010989)2.89449891
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.83810418
39Abnormality of the preputium (HP:0100587)2.83698520
40Microglossia (HP:0000171)2.81521251
41Meckel diverticulum (HP:0002245)2.81251824
42Abnormality of the prostate (HP:0008775)2.81216396
43Oligodactyly (hands) (HP:0001180)2.80708704
44Hyperammonemia (HP:0001987)2.78880780
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.78631931
46Abnormality of pyrimidine metabolism (HP:0004353)2.78629220
47Abnormality of methionine metabolism (HP:0010901)2.72514536
48Pancreatic cysts (HP:0001737)2.65570330
49Abnormality of serum amino acid levels (HP:0003112)2.62474795
50Abnormality of the ileum (HP:0001549)2.61286881
51Abnormality of chromosome stability (HP:0003220)2.61063037
52Hypochromic microcytic anemia (HP:0004840)2.59568743
53Oligodactyly (HP:0012165)2.58958548
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58549235
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58045606
56Fat malabsorption (HP:0002630)2.57248769
57Abnormality of alanine metabolism (HP:0010916)2.54163353
58Hyperalaninemia (HP:0003348)2.54163353
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54163353
60Patellar aplasia (HP:0006443)2.53276578
61Confusion (HP:0001289)2.51470417
62Abnormality of the hepatic vasculature (HP:0006707)2.50893522
63Conjugated hyperbilirubinemia (HP:0002908)2.50520948
64Abnormality of nucleobase metabolism (HP:0010932)2.48193209
65Acute myeloid leukemia (HP:0004808)2.47409100
66Breast aplasia (HP:0100783)2.45935381
67Fair hair (HP:0002286)2.42001539
68Abnormality of the common coagulation pathway (HP:0010990)2.37206223
69Amelogenesis imperfecta (HP:0000705)2.34975430
70Aplasia/Hypoplasia of the patella (HP:0006498)2.34471441
71Abnormality of purine metabolism (HP:0004352)2.32975203
72Colon cancer (HP:0003003)2.30371994
73Generalized aminoaciduria (HP:0002909)2.30003401
74Adrenal hypoplasia (HP:0000835)2.29384627
75Aplasia/Hypoplasia of the breasts (HP:0010311)2.24547041
76Increased purine levels (HP:0004368)2.22409067
77Hyperuricemia (HP:0002149)2.22409067
78Atrioventricular block (HP:0001678)2.20614461
79Partial agenesis of the corpus callosum (HP:0001338)2.19437881
80Abnormality of male internal genitalia (HP:0000022)2.17916835
81Abnormality of urine glucose concentration (HP:0011016)2.17513072
82Glycosuria (HP:0003076)2.17513072
83Male infertility (HP:0003251)2.17082336
84Clubbing of toes (HP:0100760)2.14809605
85Shawl scrotum (HP:0000049)2.14376426
86Metabolic acidosis (HP:0001942)2.13451936
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11422703
88Concave nail (HP:0001598)2.10390870
89Multiple enchondromatosis (HP:0005701)2.09387486
90Osteomalacia (HP:0002749)2.07339253
91Abnormality of the renal cortex (HP:0011035)2.04814047
92Tetraplegia (HP:0002445)2.03629086
93Oral leukoplakia (HP:0002745)2.00128327
94Gastrointestinal infarctions (HP:0005244)1.98318590
95Abnormality of complement system (HP:0005339)1.97617072
96Hepatocellular carcinoma (HP:0001402)1.96692515
97Hyperventilation (HP:0002883)1.96640479
98Hyperglycemia (HP:0003074)1.96298854
99Polycythemia (HP:0001901)1.96130798
100Abnormal delivery (HP:0001787)1.95710177
101Thyroid carcinoma (HP:0002890)1.95238375
102Delayed CNS myelination (HP:0002188)1.95145941
103Rickets (HP:0002748)1.94177540
104Enlarged kidneys (HP:0000105)1.93508613
105Septo-optic dysplasia (HP:0100842)1.93035196
106Hyperphosphaturia (HP:0003109)1.92877389
107Reduced antithrombin III activity (HP:0001976)1.92566673
108Triphalangeal thumb (HP:0001199)1.90258461
109Neonatal hypoglycemia (HP:0001998)1.89609468
110Bifid tongue (HP:0010297)1.88773125
111Steatorrhea (HP:0002570)1.88084869
112Chronic hepatic failure (HP:0100626)1.87901379
113Ectopic kidney (HP:0000086)1.87890703
114Acute lymphatic leukemia (HP:0006721)1.87547514
115Pancreatic fibrosis (HP:0100732)1.86825043
116Ketosis (HP:0001946)1.84808853
117Hypercholesterolemia (HP:0003124)1.83899312
118Arteriovenous malformation (HP:0100026)1.82353579
119Abnormality of the carotid arteries (HP:0005344)1.81864246
120Short thumb (HP:0009778)1.80641797
121Hypophosphatemic rickets (HP:0004912)1.79023330
122Lipid accumulation in hepatocytes (HP:0006561)1.78569073
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78111292
124Sloping forehead (HP:0000340)1.78025121
125Anal atresia (HP:0002023)1.76849100
126Glomerulonephritis (HP:0000099)1.76563964
127True hermaphroditism (HP:0010459)1.75430283
128Nephronophthisis (HP:0000090)1.73777569
129Pendular nystagmus (HP:0012043)1.73574609
130Abnormality of the duodenum (HP:0002246)1.73518029
131Molar tooth sign on MRI (HP:0002419)1.72241493
132Abnormality of midbrain morphology (HP:0002418)1.72241493
133Limb hypertonia (HP:0002509)1.71971352
134Cerebral edema (HP:0002181)1.70136775
135Supernumerary spleens (HP:0009799)1.68943253
136Carpal bone hypoplasia (HP:0001498)1.68846590
137Absent radius (HP:0003974)1.66462468
138Lethargy (HP:0001254)1.66108129
139Myelodysplasia (HP:0002863)1.65943143
140Nephroblastoma (Wilms tumor) (HP:0002667)1.64592730
141Genital tract atresia (HP:0001827)1.64272366
142Vaginal atresia (HP:0000148)1.64110705
143Breast carcinoma (HP:0003002)1.64044253
144Poor coordination (HP:0002370)1.63630809
145Bifid scrotum (HP:0000048)1.63481948
146Acute encephalopathy (HP:0006846)1.58601171
147Abnormality of the renal medulla (HP:0100957)1.58408611
148Opisthotonus (HP:0002179)1.56096345
149Congenital primary aphakia (HP:0007707)1.55762172
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.55215626
151Delayed puberty (HP:0000823)1.54494425
152Absent forearm bone (HP:0003953)1.54028642
153Aplasia involving forearm bones (HP:0009822)1.54028642
154Optic nerve hypoplasia (HP:0000609)1.53553254
155Dandy-Walker malformation (HP:0001305)1.52697245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS26.05568376
2LATS15.33362539
3STK38L4.86210923
4SRPK12.61735453
5ERBB42.48660673
6STK32.48560128
7DYRK22.48034191
8CDC72.41194124
9BRSK22.31772004
10CASK2.17304712
11WEE12.16883520
12DYRK32.16386512
13FRK2.13248472
14MAP3K62.06960546
15NEK22.02613754
16TAF11.99097223
17ACVR1B1.92376721
18PLK41.89777904
19BMPR1B1.89012129
20TSSK61.78542062
21CDK31.75462719
22VRK21.74502969
23ABL21.69154782
24TTK1.66844935
25PLK11.58394525
26MKNK21.56918098
27TAOK31.54649089
28RPS6KB21.47817690
29CHEK21.47780149
30MAP2K21.47170511
31EEF2K1.40824592
32PNCK1.37759124
33TLK11.35874438
34BUB11.32175176
35MAPKAPK31.31209901
36WNK41.28865328
37STK381.27272184
38PLK31.26610246
39CDK121.25871230
40MUSK1.21389112
41OBSCN1.20844171
42EPHA31.20140123
43PKN21.17596934
44OXSR11.16501047
45PBK1.14366288
46PRKAA21.13485794
47IRAK31.13417062
48AURKB1.11293878
49PRKAA11.01831873
50CAMK1G1.01822594
51BRSK10.98657366
52CDK40.98134500
53EIF2AK20.98006510
54FLT30.97090584
55AKT30.97075878
56IRAK10.95142470
57MAP2K40.93205467
58CDK90.91659789
59CDK70.91496333
60BCKDK0.90188136
61PAK60.89399845
62NME10.87553176
63CSNK1G10.86341588
64NEK60.85705378
65CHEK10.84746417
66MARK30.84438373
67RAF10.84183101
68MELK0.83951719
69KSR20.83808346
70VRK10.83648690
71SGK20.81960565
72MAPK110.80075562
73CDK80.78499929
74PINK10.77726647
75TNIK0.77124863
76ATM0.76001933
77CAMK1D0.75298827
78DYRK1A0.72041871
79PASK0.71895575
80BCR0.69582239
81STK390.69280163
82ADRBK20.68347600
83KSR10.68252669
84MAP4K20.67387673
85INSRR0.65166711
86MAP3K50.60556001
87TYRO30.60096559
88STK240.59887387
89MAPK100.59850434
90ZAK0.59619810
91RPS6KA40.59503192
92NLK0.58544388
93FGFR20.58308406
94JAK30.57764458
95MAP2K70.56822709
96FGFR40.56757809
97PHKG10.56651707
98PHKG20.56651707
99CSNK1D0.55923052
100PRKCI0.55849213
101TRIM280.54438743
102NUAK10.54232568
103NEK10.53828327
104CDK20.53747252
105PIK3CA0.53243454
106PRKDC0.52167708
107FER0.51698949
108AURKA0.49886651
109ABL10.49762451
110PRKCZ0.49179200
111CDK10.48645793
112TNK20.48400889
113ATR0.48012915
114BRD40.47380527
115RPS6KA50.46943640
116MAPK130.46841373
117JAK20.46672789
118MAP3K40.46664055
119PRKD30.46353552
120PIK3CG0.45660546
121CSNK1G20.45478604
122CSNK1E0.45381980
123CSNK1A10.43877227
124GRK10.42780264
125EPHA40.42593207
126HIPK20.41529442
127SGK2230.40827121
128SGK4940.40827121
129MKNK10.40542786
130CDK60.38364557
131WNK30.35945949
132EIF2AK10.33828463
133SGK30.33037432
134CSNK1G30.32219138
135ERBB20.31352488
136PKN10.31286038
137FGFR30.30584124
138EIF2AK30.30132559
139TYK20.26938266
140TAOK10.26620522
141CSNK1A1L0.26000261
142BRAF0.25346670

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.04636111
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.76406568
3Nitrogen metabolism_Homo sapiens_hsa009102.97432835
4Arginine biosynthesis_Homo sapiens_hsa002202.83042305
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71249830
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67454516
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40390970
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.30167381
9Complement and coagulation cascades_Homo sapiens_hsa046102.19781296
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.12568829
11Pentose phosphate pathway_Homo sapiens_hsa000302.10050260
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08651070
13Tryptophan metabolism_Homo sapiens_hsa003802.07423066
14RNA polymerase_Homo sapiens_hsa030201.99727172
15Butanoate metabolism_Homo sapiens_hsa006501.89327599
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.80785828
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79596350
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76349319
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.74224425
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73364281
21Retinol metabolism_Homo sapiens_hsa008301.66116357
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61940816
23Basal transcription factors_Homo sapiens_hsa030221.61182401
24Histidine metabolism_Homo sapiens_hsa003401.59567802
25Cell cycle_Homo sapiens_hsa041101.59476907
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58901701
27beta-Alanine metabolism_Homo sapiens_hsa004101.58605402
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58245989
29Fatty acid degradation_Homo sapiens_hsa000711.58175002
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55535846
31Peroxisome_Homo sapiens_hsa041461.53566706
32Chemical carcinogenesis_Homo sapiens_hsa052041.53304212
33Vitamin digestion and absorption_Homo sapiens_hsa049771.51276186
34Biosynthesis of amino acids_Homo sapiens_hsa012301.49476291
35Fanconi anemia pathway_Homo sapiens_hsa034601.47012009
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.45204217
37Steroid biosynthesis_Homo sapiens_hsa001001.42260081
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.36778888
39Selenocompound metabolism_Homo sapiens_hsa004501.31340290
40Folate biosynthesis_Homo sapiens_hsa007901.30084778
41Staphylococcus aureus infection_Homo sapiens_hsa051501.29372834
42Arginine and proline metabolism_Homo sapiens_hsa003301.28757275
43PPAR signaling pathway_Homo sapiens_hsa033201.24574671
44Non-homologous end-joining_Homo sapiens_hsa034501.19337067
45Tyrosine metabolism_Homo sapiens_hsa003501.15907958
46DNA replication_Homo sapiens_hsa030301.15696356
47Lysine degradation_Homo sapiens_hsa003101.14813974
48Propanoate metabolism_Homo sapiens_hsa006401.12233883
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10483981
50Phenylalanine metabolism_Homo sapiens_hsa003601.10419380
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.07551547
52One carbon pool by folate_Homo sapiens_hsa006701.04764687
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04740536
54Sulfur relay system_Homo sapiens_hsa041221.02921256
55Mismatch repair_Homo sapiens_hsa034301.02037331
56Fatty acid metabolism_Homo sapiens_hsa012121.01775823
57Caffeine metabolism_Homo sapiens_hsa002320.99971931
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94747883
59Circadian rhythm_Homo sapiens_hsa047100.92769996
60Homologous recombination_Homo sapiens_hsa034400.91803907
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91762064
62Base excision repair_Homo sapiens_hsa034100.91397857
63Bile secretion_Homo sapiens_hsa049760.89869115
64RNA transport_Homo sapiens_hsa030130.84230061
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82371736
66ABC transporters_Homo sapiens_hsa020100.80909112
67p53 signaling pathway_Homo sapiens_hsa041150.80876076
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77055982
69Pyrimidine metabolism_Homo sapiens_hsa002400.73179943
70RNA degradation_Homo sapiens_hsa030180.70639318
71Starch and sucrose metabolism_Homo sapiens_hsa005000.69740362
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.68187362
73Fatty acid elongation_Homo sapiens_hsa000620.66955304
74Carbon metabolism_Homo sapiens_hsa012000.65963899
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64535680
76Linoleic acid metabolism_Homo sapiens_hsa005910.64221082
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60053212
78Glycerolipid metabolism_Homo sapiens_hsa005610.56825074
79Nucleotide excision repair_Homo sapiens_hsa034200.56341226
80Regulation of autophagy_Homo sapiens_hsa041400.56205151
81Glutathione metabolism_Homo sapiens_hsa004800.54355156
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54214321
83Fat digestion and absorption_Homo sapiens_hsa049750.52238850
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50117429
85Phototransduction_Homo sapiens_hsa047440.49055843
86Purine metabolism_Homo sapiens_hsa002300.47347628
87mRNA surveillance pathway_Homo sapiens_hsa030150.47333994
88Metabolic pathways_Homo sapiens_hsa011000.44024024
89TGF-beta signaling pathway_Homo sapiens_hsa043500.43781492
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.40458010
91Pyruvate metabolism_Homo sapiens_hsa006200.39006288
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37961441
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32942405
94Sulfur metabolism_Homo sapiens_hsa009200.32295692
95Herpes simplex infection_Homo sapiens_hsa051680.31103734
96Oocyte meiosis_Homo sapiens_hsa041140.30092202
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29267262
98Ovarian steroidogenesis_Homo sapiens_hsa049130.28359677
99Ether lipid metabolism_Homo sapiens_hsa005650.26084898
100Fatty acid biosynthesis_Homo sapiens_hsa000610.25800507
101Systemic lupus erythematosus_Homo sapiens_hsa053220.23897278
102MicroRNAs in cancer_Homo sapiens_hsa052060.23731174
103Sphingolipid metabolism_Homo sapiens_hsa006000.23358257
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23233545
105Insulin resistance_Homo sapiens_hsa049310.21533348
106AMPK signaling pathway_Homo sapiens_hsa041520.20958844
107Glucagon signaling pathway_Homo sapiens_hsa049220.20603643
108Arachidonic acid metabolism_Homo sapiens_hsa005900.20528201
109Spliceosome_Homo sapiens_hsa030400.20128866
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19674254
111Choline metabolism in cancer_Homo sapiens_hsa052310.16703294
112FoxO signaling pathway_Homo sapiens_hsa040680.16092751
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14753762
114Oxidative phosphorylation_Homo sapiens_hsa001900.10124512
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08057484
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05787049
117Huntingtons disease_Homo sapiens_hsa050160.02770715
118Parkinsons disease_Homo sapiens_hsa050120.02255192
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01816625

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