DHX16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.76601232
2negative regulation of macroautophagy (GO:0016242)5.83517697
3detection of molecule of bacterial origin (GO:0032490)5.41589233
4positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.23405780
5post-embryonic morphogenesis (GO:0009886)5.16239401
6negative regulation of meiosis (GO:0045835)4.54862420
7Golgi transport vesicle coating (GO:0048200)4.52770261
8COPI coating of Golgi vesicle (GO:0048205)4.52770261
9paraxial mesoderm development (GO:0048339)4.23017930
10auditory receptor cell stereocilium organization (GO:0060088)4.12393346
11sulfate transmembrane transport (GO:1902358)4.00279992
12energy homeostasis (GO:0097009)3.80963164
13nuclear pore organization (GO:0006999)3.80780561
14mitotic chromosome condensation (GO:0007076)3.77858884
15pentose-phosphate shunt (GO:0006098)3.75347085
16proline biosynthetic process (GO:0006561)3.74922562
17protein maturation by protein folding (GO:0022417)3.74874129
18cellular anion homeostasis (GO:0030002)3.65633684
19sulfate transport (GO:0008272)3.64134930
20regulation of gene silencing by RNA (GO:0060966)3.62212530
21regulation of posttranscriptional gene silencing (GO:0060147)3.62212530
22regulation of gene silencing by miRNA (GO:0060964)3.62212530
23phosphate ion homeostasis (GO:0055062)3.58808990
24trivalent inorganic anion homeostasis (GO:0072506)3.58808990
25regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.54986599
26detection of external biotic stimulus (GO:0098581)3.51610378
27lateral ventricle development (GO:0021670)3.51089698
28pore complex assembly (GO:0046931)3.49167789
29nuclear pore complex assembly (GO:0051292)3.45056199
30DNA replication initiation (GO:0006270)3.42154587
31NADPH regeneration (GO:0006740)3.35139642
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30247429
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.30247429
34regulation of histone H3-K9 methylation (GO:0051570)3.28464097
35folic acid-containing compound biosynthetic process (GO:0009396)3.27953710
36regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.26491670
37IMP biosynthetic process (GO:0006188)3.25675901
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.23268457
39histone H3-K9 modification (GO:0061647)3.20380186
40pinocytosis (GO:0006907)3.18167896
41protein K6-linked ubiquitination (GO:0085020)3.14736066
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13178315
43regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.10683249
44glucose catabolic process (GO:0006007)3.10371234
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09791476
46determination of adult lifespan (GO:0008340)3.08918425
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.08048263
48histone H4-K12 acetylation (GO:0043983)3.07496114
49tRNA methylation (GO:0030488)3.06432609
50negative regulation of histone methylation (GO:0031061)3.01095993
51regulation of interleukin-6 biosynthetic process (GO:0045408)2.98669456
52DNA unwinding involved in DNA replication (GO:0006268)2.97722386
53mitotic metaphase plate congression (GO:0007080)2.97634228
54regulation of telomere maintenance via telomerase (GO:0032210)2.97086535
55protein localization to endosome (GO:0036010)2.96550214
56detection of biotic stimulus (GO:0009595)2.96522170
57apoptotic process involved in morphogenesis (GO:0060561)2.94691690
58mitotic sister chromatid segregation (GO:0000070)2.93564276
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92174904
60peptidyl-lysine dimethylation (GO:0018027)2.91566080
61regulation of helicase activity (GO:0051095)2.88692095
62DNA replication-dependent nucleosome assembly (GO:0006335)2.87997779
63DNA replication-dependent nucleosome organization (GO:0034723)2.87997779
64mitotic nuclear envelope disassembly (GO:0007077)2.87046405
65positive regulation of SMAD protein import into nucleus (GO:0060391)2.86800923
66regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86326241
67nucleobase biosynthetic process (GO:0046112)2.86007229
68regulation of superoxide anion generation (GO:0032928)2.85541489
69regulation of centrosome cycle (GO:0046605)2.83057345
70ribosome biogenesis (GO:0042254)2.82651400
71negative regulation of erythrocyte differentiation (GO:0045647)2.81841334
72positive regulation of DNA-dependent DNA replication (GO:2000105)2.81813072
73protein localization to kinetochore (GO:0034501)2.78494351
74DNA strand elongation involved in DNA replication (GO:0006271)2.78454261
75regulation of translational fidelity (GO:0006450)2.76131873
76nucleobase-containing small molecule interconversion (GO:0015949)2.75170898
773-UTR-mediated mRNA stabilization (GO:0070935)2.74071066
78DNA catabolic process, exonucleolytic (GO:0000738)2.71985680
79prostate gland growth (GO:0060736)2.65524228
80protein retention in ER lumen (GO:0006621)2.64466814
81DNA strand elongation (GO:0022616)2.63967956
82sulfur compound transport (GO:0072348)2.63963879
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63302880
84chromosome condensation (GO:0030261)2.63005826
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62350098
86embryonic process involved in female pregnancy (GO:0060136)2.62331730
87dosage compensation (GO:0007549)2.62285661
88negative regulation of cell size (GO:0045792)2.61316364
89ribosome assembly (GO:0042255)2.60291123
90sister chromatid segregation (GO:0000819)2.58154409
91activation of Rac GTPase activity (GO:0032863)2.57644860
92membrane disassembly (GO:0030397)2.57510260
93nuclear envelope disassembly (GO:0051081)2.57510260
94negative regulation of response to extracellular stimulus (GO:0032105)2.57487208
95negative regulation of response to nutrient levels (GO:0032108)2.57487208
96regulation of translational termination (GO:0006449)2.57453222
97heterochromatin organization (GO:0070828)2.57250438
98DNA duplex unwinding (GO:0032508)2.56462317
99NIK/NF-kappaB signaling (GO:0038061)2.56150924
100DNA replication checkpoint (GO:0000076)2.55290710
101DNA geometric change (GO:0032392)2.55074972
102regulation of DNA endoreduplication (GO:0032875)2.54992928
103embryonic placenta development (GO:0001892)2.53944541
104cellular protein complex localization (GO:0034629)2.53343956
105glucose 6-phosphate metabolic process (GO:0051156)2.52959945
106IMP metabolic process (GO:0046040)2.52936281
107protein export from nucleus (GO:0006611)2.52909594
108barbed-end actin filament capping (GO:0051016)2.51374277
109histone mRNA catabolic process (GO:0071044)2.51231797
110regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51016570
111cellular hyperosmotic response (GO:0071474)2.50935967
112purine nucleobase biosynthetic process (GO:0009113)2.50563907
113telomere maintenance via semi-conservative replication (GO:0032201)2.49662839
114regulation of mitochondrial translation (GO:0070129)2.49184679
115skin morphogenesis (GO:0043589)2.46878403
116regulation of centrosome duplication (GO:0010824)2.46139804
117regulation of early endosome to late endosome transport (GO:2000641)2.44737564
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44450468
119positive regulation of nuclease activity (GO:0032075)2.44069225
120pre-miRNA processing (GO:0031054)2.43843452
121positive regulation of neurological system process (GO:0031646)2.43740906
122NADH metabolic process (GO:0006734)2.43739358
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.43720830
124exogenous drug catabolic process (GO:0042738)2.43415263
125metaphase plate congression (GO:0051310)2.43173432
126cranial suture morphogenesis (GO:0060363)2.42628346
127establishment of apical/basal cell polarity (GO:0035089)2.42425034
128branching involved in mammary gland duct morphogenesis (GO:0060444)2.42055430
129regulation of gene silencing (GO:0060968)2.41017549
130peptidyl-arginine omega-N-methylation (GO:0035247)2.39966256
131proline metabolic process (GO:0006560)2.37293454
132regulation of RNA export from nucleus (GO:0046831)2.36804514
133regulation of histone H3-K27 methylation (GO:0061085)2.36604202
134negative regulation of glial cell proliferation (GO:0060253)2.36554431
135RNA stabilization (GO:0043489)2.36548254
136mRNA stabilization (GO:0048255)2.36548254
137protein localization to chromosome, centromeric region (GO:0071459)2.36255066
138protein complex localization (GO:0031503)2.36004706
139negative regulation of necroptotic process (GO:0060546)2.35631390
140modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35410107
141positive regulation by organism of defense response of other organism involved in symbiotic interact2.35410107
142modulation by symbiont of host immune response (GO:0052553)2.35410107
143positive regulation by symbiont of host defense response (GO:0052509)2.35410107
144modulation by symbiont of host defense response (GO:0052031)2.35410107
145modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35410107
146formation of translation preinitiation complex (GO:0001731)2.35335982
147negative regulation of viral release from host cell (GO:1902187)2.33671183
148maintenance of gastrointestinal epithelium (GO:0030277)2.32897987
149positive regulation of protein homooligomerization (GO:0032464)2.32324312
150ribonucleoprotein complex biogenesis (GO:0022613)2.32296599
151kinetochore assembly (GO:0051382)2.31713638
152establishment of integrated proviral latency (GO:0075713)2.30732537
153response to peptidoglycan (GO:0032494)2.29625632
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29487170
155focal adhesion assembly (GO:0048041)2.27598571
156cell-substrate adherens junction assembly (GO:0007045)2.27598571
157maternal placenta development (GO:0001893)2.25857656
158endoplasmic reticulum unfolded protein response (GO:0030968)2.25697742
159establishment of viral latency (GO:0019043)2.25548545
160regulation of nuclease activity (GO:0032069)2.24336717
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24008554
162ribosomal small subunit biogenesis (GO:0042274)2.22117824
163regulation of nucleobase-containing compound transport (GO:0032239)2.22083443
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.20539057
165pentose metabolic process (GO:0019321)2.19669028
166DNA packaging (GO:0006323)2.19104636
167mitochondrial fusion (GO:0008053)2.16909705
168adherens junction assembly (GO:0034333)2.16760979
169snRNA metabolic process (GO:0016073)2.16565130
170GDP-mannose metabolic process (GO:0019673)2.15064479
171regulation of mitotic spindle organization (GO:0060236)2.14991798
172stress fiber assembly (GO:0043149)2.14430751
173nuclear envelope organization (GO:0006998)2.13030661
174ER-nucleus signaling pathway (GO:0006984)2.12365003
175positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.12178602
176negative regulation of mRNA metabolic process (GO:1903312)2.11196655
177endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.11091151
178glycolytic process (GO:0006096)2.11015052
179doxorubicin metabolic process (GO:0044598)15.0883481
180daunorubicin metabolic process (GO:0044597)15.0883481
181polyketide metabolic process (GO:0030638)15.0883481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.99457637
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.11110747
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.26075813
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.26075813
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.26075813
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.79253724
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.68315697
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30216221
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10408250
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08837695
11NANOG_18555785_ChIP-Seq_MESCs_Mouse2.81145717
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.72114454
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.58578833
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.44739604
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.40758712
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39092735
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37819343
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.35564554
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29145964
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25879285
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17640969
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.17469106
23NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.16141166
24MYC_22102868_ChIP-Seq_BL_Human2.12691791
25SOX2_18555785_ChIP-Seq_MESCs_Mouse2.04842767
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.03911865
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.03819980
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.96647632
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95624420
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95238509
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92455441
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90986863
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.90712104
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86859716
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80997233
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79118830
37ZNF263_19887448_ChIP-Seq_K562_Human1.74699949
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74281431
39LXR_22292898_ChIP-Seq_THP-1_Human1.71059992
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66718572
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64132634
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62447663
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.61276470
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61087825
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60839462
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60697864
47RACK7_27058665_Chip-Seq_MCF-7_Human1.59811565
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58824850
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58592822
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58399526
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57624716
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56576014
53KAP1_27257070_Chip-Seq_ESCs_Mouse1.56389665
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.55140932
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52879888
56AR_21909140_ChIP-Seq_LNCAP_Human1.51882022
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48926573
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46917002
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45801378
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45545631
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44730158
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41969031
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41483268
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40617444
65TFEB_21752829_ChIP-Seq_HELA_Human1.39688445
66SOX2_18692474_ChIP-Seq_MESCs_Mouse1.39560909
67NANOG_18692474_ChIP-Seq_MESCs_Mouse1.37969282
68SCL_19346495_ChIP-Seq_HPC-7_Human1.37216016
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37191664
70CLOCK_20551151_ChIP-Seq_293T_Human1.35019232
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35000911
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33174792
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32816976
74MAF_26560356_Chip-Seq_TH1_Human1.32799074
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.32719472
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31739012
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28722417
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27793651
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27615108
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26052505
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.25440238
82ATF3_27146783_Chip-Seq_COLON_Human1.24212358
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24192526
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23962932
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23582739
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22279469
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21505525
88XRN2_22483619_ChIP-Seq_HELA_Human1.21437813
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20705745
90* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20625629
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20492309
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19713771
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19397869
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18171298
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17545865
96VDR_21846776_ChIP-Seq_THP-1_Human1.17362147
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16423258
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16218405
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.15331749
100KDM2B_26808549_Chip-Seq_DND41_Human1.15107939
101VDR_24763502_ChIP-Seq_THP-1_Human1.14897035
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14460224
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13800822
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.13746493
105* MAF_26560356_Chip-Seq_TH2_Human1.13698443
106POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13254942
107UTX_26944678_Chip-Seq_JUKART_Human1.12630602
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12208697
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.11706378
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08948173
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08416302
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08148672
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07957847
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07263760
115SPI1_23547873_ChIP-Seq_NB4_Human1.07208920
116* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07106710
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05297548
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04469221
119* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04235407
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04230760
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03907228
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03674845
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02710905
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02107308
125P68_20966046_ChIP-Seq_HELA_Human1.01955676
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01949222
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01865080
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.01653882
129* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01135805
130VDR_23849224_ChIP-Seq_CD4+_Human1.00589160
131* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99544536
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99048317
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99001251
134KDM5A_27292631_Chip-Seq_BREAST_Human0.97822720
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95977824
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95632328
137TTF2_22483619_ChIP-Seq_HELA_Human0.95358120
138PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94311301
139* FOXP3_21729870_ChIP-Seq_TREG_Human0.93636195
140CIITA_25753668_ChIP-Seq_RAJI_Human0.92430656
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.92204629
142IRF1_19129219_ChIP-ChIP_H3396_Human0.90416728
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89331546
144NANOG_16518401_ChIP-PET_MESCs_Mouse0.88334778
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87096521
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85811903
147* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85607711
148* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81453677
149GABP_19822575_ChIP-Seq_HepG2_Human0.81262867
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.77937723
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77326419
152YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76439394
153TCF7_22412390_ChIP-Seq_EML_Mouse0.72909686
154TP53_22127205_ChIP-Seq_IMR90_Human0.71318898
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.70729909
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68094953
157NCOR1_26117541_ChIP-Seq_K562_Human0.67296342
158* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66047575
159DCP1A_22483619_ChIP-Seq_HELA_Human0.63361311
160EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.62863198
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.62465180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.78979428
2MP0003878_abnormal_ear_physiology5.78979428
3MP0008004_abnormal_stomach_pH4.25617902
4MP0003941_abnormal_skin_development3.83704130
5MP0005451_abnormal_body_composition3.47791817
6MP0003111_abnormal_nucleus_morphology3.23289201
7MP0010094_abnormal_chromosome_stability3.12647462
8MP0008057_abnormal_DNA_replication3.08592797
9MP0003693_abnormal_embryo_hatching2.97319677
10MP0005058_abnormal_lysosome_morphology2.87409558
11MP0000566_synostosis2.85497065
12MP0004957_abnormal_blastocyst_morpholog2.78304503
13MP0008260_abnormal_autophagy2.69485373
14MP0003077_abnormal_cell_cycle2.69441763
15MP0002877_abnormal_melanocyte_morpholog2.65692273
16MP0000678_abnormal_parathyroid_gland2.43324317
17MP0006292_abnormal_olfactory_placode2.28701501
18MP0010234_abnormal_vibrissa_follicle2.15153496
19MP0009840_abnormal_foam_cell2.15040729
20MP0008058_abnormal_DNA_repair2.09262036
21MP0002132_abnormal_respiratory_system2.08438403
22MP0003436_decreased_susceptibility_to2.06595753
23MP0002396_abnormal_hematopoietic_system2.01740201
24MP0001293_anophthalmia1.98691742
25MP0003300_gastrointestinal_ulcer1.94945031
26MP0009697_abnormal_copulation1.92442804
27MP0005645_abnormal_hypothalamus_physiol1.89720704
28MP0004233_abnormal_muscle_weight1.85133162
29MP0001346_abnormal_lacrimal_gland1.75318325
30MP0003172_abnormal_lysosome_physiology1.73188018
31MP0003566_abnormal_cell_adhesion1.69454380
32MP0010352_gastrointestinal_tract_polyps1.63735154
33MP0001849_ear_inflammation1.62560942
34MP0009333_abnormal_splenocyte_physiolog1.61631562
35MP0001485_abnormal_pinna_reflex1.59299843
36MP0003303_peritoneal_inflammation1.57009815
37MP0002277_abnormal_respiratory_mucosa1.55465567
38MP0004133_heterotaxia1.49094527
39MP0008007_abnormal_cellular_replicative1.47947400
40MP0003705_abnormal_hypodermis_morpholog1.43164984
41MP0000350_abnormal_cell_proliferation1.43156754
42MP0004947_skin_inflammation1.43063917
43MP0004264_abnormal_extraembryonic_tissu1.38257456
44MP0003879_abnormal_hair_cell1.37983134
45MP0003806_abnormal_nucleotide_metabolis1.35342807
46MP0010307_abnormal_tumor_latency1.33719210
47MP0003221_abnormal_cardiomyocyte_apopto1.33342370
48MP0003786_premature_aging1.32920629
49MP0002085_abnormal_embryonic_tissue1.32798419
50MP0005248_abnormal_Harderian_gland1.31950282
51MP0003191_abnormal_cellular_cholesterol1.27580440
52MP0005380_embryogenesis_phenotype1.23832002
53MP0001672_abnormal_embryogenesis/_devel1.23832002
54MP0002796_impaired_skin_barrier1.18346805
55MP0000490_abnormal_crypts_of1.17122053
56MP0002086_abnormal_extraembryonic_tissu1.15811716
57MP0001919_abnormal_reproductive_system1.14956350
58MP0005501_abnormal_skin_physiology1.14598454
59MP0001348_abnormal_lacrimal_gland1.13951309
60MP0003656_abnormal_erythrocyte_physiolo1.13921169
61MP0005389_reproductive_system_phenotype1.13385269
62MP0005023_abnormal_wound_healing1.13328864
63MP0003718_maternal_effect1.12999159
64MP0004858_abnormal_nervous_system1.12945315
65MP0001730_embryonic_growth_arrest1.12279185
66MP0002210_abnormal_sex_determination1.11922134
67MP0002084_abnormal_developmental_patter1.11723968
68MP0005464_abnormal_platelet_physiology1.10175653
69MP0005621_abnormal_cell_physiology1.10052785
70MP0009278_abnormal_bone_marrow1.09974884
71MP0004197_abnormal_fetal_growth/weight/1.09572439
72MP0003091_abnormal_cell_migration1.09254166
73MP0002938_white_spotting1.08097470
74MP0002419_abnormal_innate_immunity1.07089879
75MP0001915_intracranial_hemorrhage1.06239593
76MP0003936_abnormal_reproductive_system1.04627878
77MP0005025_abnormal_response_to1.03962748
78MP0002060_abnormal_skin_morphology1.03399145
79MP0008932_abnormal_embryonic_tissue1.02982690
80MP0002139_abnormal_hepatobiliary_system1.02608315
81MP0001986_abnormal_taste_sensitivity1.01546276
82MP0000685_abnormal_immune_system1.01500089
83MP0001661_extended_life_span1.01024446
84MP0000470_abnormal_stomach_morphology1.00191900
85MP0003453_abnormal_keratinocyte_physiol0.99687692
86MP0005076_abnormal_cell_differentiation0.99522560
87MP0000747_muscle_weakness0.98789516
88MP0000627_abnormal_mammary_gland0.97951918
89MP0003984_embryonic_growth_retardation0.97745640
90MP0000858_altered_metastatic_potential0.97095364
91MP0008438_abnormal_cutaneous_collagen0.96870396
92MP0001835_abnormal_antigen_presentation0.96431702
93MP0002088_abnormal_embryonic_growth/wei0.95459447
94MP0002398_abnormal_bone_marrow0.95366815
95MP0000003_abnormal_adipose_tissue0.94864244
96MP0002098_abnormal_vibrissa_morphology0.94506809
97MP0005257_abnormal_intraocular_pressure0.92537708
98MP0005666_abnormal_adipose_tissue0.92094461
99MP0000516_abnormal_urinary_system0.91733223
100MP0005367_renal/urinary_system_phenotyp0.91733223
101MP0000313_abnormal_cell_death0.91710244
102MP0002722_abnormal_immune_system0.90036122
103MP0001853_heart_inflammation0.90027289
104MP0004742_abnormal_vestibular_system0.89604225
105MP0005384_cellular_phenotype0.89412694
106MP0003890_abnormal_embryonic-extraembry0.89059053
107MP0002075_abnormal_coat/hair_pigmentati0.88950588
108MP0001216_abnormal_epidermal_layer0.88773704
109MP0005647_abnormal_sex_gland0.88682118
110MP0005310_abnormal_salivary_gland0.88604670
111MP0001145_abnormal_male_reproductive0.88015377
112MP0000427_abnormal_hair_cycle0.87490858
113MP0002019_abnormal_tumor_incidence0.87463696
114MP0000733_abnormal_muscle_development0.86533547
115MP0005000_abnormal_immune_tolerance0.86418786
116MP0002249_abnormal_larynx_morphology0.86215526
117MP0001119_abnormal_female_reproductive0.86078882
118MP0005375_adipose_tissue_phenotype0.86054067
119MP0002080_prenatal_lethality0.85050223
120MP0000609_abnormal_liver_physiology0.84997000
121MP0002405_respiratory_system_inflammati0.84684541
122MP0002111_abnormal_tail_morphology0.84147583
123MP0002429_abnormal_blood_cell0.83787772
124MP0002089_abnormal_postnatal_growth/wei0.82932695
125MP0005360_urolithiasis0.82651788
126MP0000358_abnormal_cell_content/0.81623602
127MP0003119_abnormal_digestive_system0.81377745
128MP0002452_abnormal_antigen_presenting0.81307025
129MP0005623_abnormal_meninges_morphology0.80351210
130MP0001533_abnormal_skeleton_physiology0.79821999
131MP0001697_abnormal_embryo_size0.79165769
132MP0000703_abnormal_thymus_morphology0.78470522
133MP0002723_abnormal_immune_serum0.78031307
134MP0002420_abnormal_adaptive_immunity0.77922489
135MP0005409_darkened_coat_color0.77855251
136MP0001819_abnormal_immune_cell0.77720812
137MP0003937_abnormal_limbs/digits/tail_de0.76728278
138MP0005387_immune_system_phenotype0.75784115
139MP0001790_abnormal_immune_system0.75784115
140MP0009672_abnormal_birth_weight0.75336245
141MP0000653_abnormal_sex_gland0.74833668
142MP0005670_abnormal_white_adipose0.74733276
143MP0003646_muscle_fatigue0.74568502
144MP0003763_abnormal_thymus_physiology0.74458919
145MP0002092_abnormal_eye_morphology0.72851395
146MP0003950_abnormal_plasma_membrane0.72751313
147MP0001286_abnormal_eye_development0.72546339
148MP0002697_abnormal_eye_size0.72006431
149MP0010030_abnormal_orbit_morphology0.71778578
150MP0003045_fibrosis0.66413531
151MP0001929_abnormal_gametogenesis0.65972874
152MP0000681_abnormal_thyroid_gland0.65118858
153MP0005397_hematopoietic_system_phenotyp0.64468074
154MP0001545_abnormal_hematopoietic_system0.64468074
155MP0004185_abnormal_adipocyte_glucose0.62851062
156MP0004808_abnormal_hematopoietic_stem0.62659510
157MP0003699_abnormal_female_reproductive0.61850714
158MP0005379_endocrine/exocrine_gland_phen0.61430434

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)6.75405398
2Alopecia of scalp (HP:0002293)6.71746948
3Parakeratosis (HP:0001036)6.46874287
4Bilateral sensorineural hearing impairment (HP:0008619)5.40166537
5Cheilitis (HP:0100825)4.98149111
6Follicular hyperkeratosis (HP:0007502)4.87650031
7Abnormality of dental color (HP:0011073)4.21220710
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.05580435
9Absent eyelashes (HP:0000561)4.04886250
10Chromsome breakage (HP:0040012)3.86609182
11Absent eyebrow (HP:0002223)3.84865615
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.78585097
13Absent/shortened dynein arms (HP:0200106)3.78585097
14Recurrent corneal erosions (HP:0000495)3.75956793
15Chronic otitis media (HP:0000389)3.59229206
16Erythroderma (HP:0001019)3.59140788
17Blepharitis (HP:0000498)3.52597829
18Ectropion (HP:0000656)3.43056830
19Duplicated collecting system (HP:0000081)3.23503542
20Vertebral compression fractures (HP:0002953)3.19393677
21Abnormal gallbladder physiology (HP:0012438)3.18932580
22Cholecystitis (HP:0001082)3.18932580
23Ependymoma (HP:0002888)2.98106528
24Increased connective tissue (HP:0009025)2.93693351
25Ectopic kidney (HP:0000086)2.92319349
26Abnormality of the renal collecting system (HP:0004742)2.90383972
27Reticulocytopenia (HP:0001896)2.90206600
28Deep venous thrombosis (HP:0002625)2.89651182
29Abnormality of the labia minora (HP:0012880)2.82222264
30Birth length less than 3rd percentile (HP:0003561)2.73566217
31Abnormality of the distal phalanges of the toes (HP:0010182)2.70578971
32Absent radius (HP:0003974)2.65993506
33Progressive muscle weakness (HP:0003323)2.65952563
34Distal lower limb amyotrophy (HP:0008944)2.65526081
35Achilles tendon contracture (HP:0001771)2.65520734
36Patellar aplasia (HP:0006443)2.64879769
37Rib fusion (HP:0000902)2.56714276
38Neoplasm of the respiratory system (HP:0100606)2.56598144
39Ragged-red muscle fibers (HP:0003200)2.56517457
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.56209296
41Fatigue (HP:0012378)2.55216063
42Abnormality of pyrimidine metabolism (HP:0004353)2.53337835
43Distal lower limb muscle weakness (HP:0009053)2.49266532
44Aplasia involving forearm bones (HP:0009822)2.48284786
45Absent forearm bone (HP:0003953)2.48284786
46Abnormality of the Achilles tendon (HP:0005109)2.47399045
47Progressive external ophthalmoplegia (HP:0000590)2.44540791
48Hyperacusis (HP:0010780)2.44183010
49Abnormality of the preputium (HP:0100587)2.43353886
50Flat acetabular roof (HP:0003180)2.42584462
51Meckel diverticulum (HP:0002245)2.40489710
52Aplasia/Hypoplasia of the patella (HP:0006498)2.37752834
53Breast hypoplasia (HP:0003187)2.36903805
54Abolished electroretinogram (ERG) (HP:0000550)2.35001837
55Eczematoid dermatitis (HP:0000976)2.34621726
56Premature rupture of membranes (HP:0001788)2.33208568
57Medulloblastoma (HP:0002885)2.33151140
58Rhabdomyosarcoma (HP:0002859)2.31618149
59Sparse eyelashes (HP:0000653)2.31590250
60Short nail (HP:0001799)2.30257683
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.30172049
62Small epiphyses (HP:0010585)2.30018327
63Abnormality of the ileum (HP:0001549)2.28487820
64Abnormality of chromosome stability (HP:0003220)2.28096239
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26288462
66Neoplasm of the oral cavity (HP:0100649)2.25126359
67Abnormality of macrophages (HP:0004311)2.24496517
68Hyperphosphatemia (HP:0002905)2.23727576
69Absent thumb (HP:0009777)2.21306943
70Supernumerary ribs (HP:0005815)2.18050321
71Agnosia (HP:0010524)2.17564769
72Abnormal respiratory epithelium morphology (HP:0012253)2.15340050
73Abnormal respiratory motile cilium morphology (HP:0005938)2.15340050
74Broad face (HP:0000283)2.14678650
75Supernumerary bones of the axial skeleton (HP:0009144)2.13976483
76Neoplasm of the lung (HP:0100526)2.13000188
77Distal upper limb amyotrophy (HP:0007149)2.12617133
78Upper limb amyotrophy (HP:0009129)2.12617133
79Microvesicular hepatic steatosis (HP:0001414)2.12496815
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10938269
81Vertebral arch anomaly (HP:0008438)2.10318431
82Palmar hyperkeratosis (HP:0010765)2.10108126
83Trismus (HP:0000211)2.09022778
84Tetany (HP:0001281)2.08776200
85Amaurosis fugax (HP:0100576)2.08030219
86Rough bone trabeculation (HP:0100670)2.06327854
87Hypohidrosis (HP:0000966)2.06298286
88Protrusio acetabuli (HP:0003179)2.05099814
89Vertebral clefting (HP:0008428)2.04545402
90Renal dysplasia (HP:0000110)2.02827686
91Nail dystrophy (HP:0008404)2.02437248
92Long palpebral fissure (HP:0000637)2.02354651
93Septo-optic dysplasia (HP:0100842)2.01629895
94Supernumerary spleens (HP:0009799)2.00858933
95Palmoplantar hyperkeratosis (HP:0000972)1.99639963
96Urticaria (HP:0001025)1.99290982
97Upper motor neuron abnormality (HP:0002127)1.98608179
98Ulnar bowing (HP:0003031)1.97523698
99Premature graying of hair (HP:0002216)1.96432063
100Biconcave vertebral bodies (HP:0004586)1.95841236
101Hemorrhage of the eye (HP:0011885)1.95736737
102Myocardial infarction (HP:0001658)1.95447109
103Osteomalacia (HP:0002749)1.94988582
104Interstitial pulmonary disease (HP:0006530)1.93567042
105Reticulocytosis (HP:0001923)1.93445368
106Chronic sinusitis (HP:0011109)1.93337390
107Abnormal ciliary motility (HP:0012262)1.91446032
108Myopathic facies (HP:0002058)1.91296886
109Disproportionate tall stature (HP:0001519)1.89549780
110Entropion (HP:0000621)1.89440320
111Hypertensive crisis (HP:0100735)1.89374658
112Erythema (HP:0010783)1.89365477
113Cellulitis (HP:0100658)1.89301739
114Asymmetry of the thorax (HP:0001555)1.89194261
115Aplasia cutis congenita (HP:0001057)1.89186732
116Axonal loss (HP:0003447)1.88873170
117Abnormality of the astrocytes (HP:0100707)1.85733564
118Astrocytoma (HP:0009592)1.85733564
119Recurrent abscess formation (HP:0002722)1.85397491
120Basal cell carcinoma (HP:0002671)1.84810154
121Corneal erosion (HP:0200020)1.84736344
122Increased serum ferritin (HP:0003281)1.84445272
123Selective tooth agenesis (HP:0001592)1.84360754
124Pendular nystagmus (HP:0012043)1.84022955
125Progressive hearing impairment (HP:0001730)1.83992862
126Cholelithiasis (HP:0001081)1.83775118
127Colitis (HP:0002583)1.82987336
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82644168
129Loss of speech (HP:0002371)1.82039836
130Hypergonadotropic hypogonadism (HP:0000815)1.82028856
131Deviation of the thumb (HP:0009603)1.81879511
132Cervical subluxation (HP:0003308)1.80777021
133Abnormality of carpal bone ossification (HP:0006257)1.79809750
134Male infertility (HP:0003251)1.78933078
135Absent hair (HP:0002298)1.78457409
136Clubbing of toes (HP:0100760)1.78229206
137Plantar hyperkeratosis (HP:0007556)1.77730460
138Impulsivity (HP:0100710)1.76586475
139Duplication of thumb phalanx (HP:0009942)1.74866051
140Keratitis (HP:0000491)1.74711655
141Ankyloglossia (HP:0010296)1.74453900
142Horseshoe kidney (HP:0000085)1.73842685
143Long eyelashes (HP:0000527)1.73168492
144Bile duct proliferation (HP:0001408)1.72709321
145Abnormal biliary tract physiology (HP:0012439)1.72709321
146Orthostatic hypotension (HP:0001278)1.72329221
147Plagiocephaly (HP:0001357)1.71104412
148Triphalangeal thumb (HP:0001199)1.70817198
149Difficulty climbing stairs (HP:0003551)1.70761233
150Shawl scrotum (HP:0000049)1.70337322
151Osteolytic defects of the hand bones (HP:0009699)1.70328617
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.70328617
153Abnormality of glycolysis (HP:0004366)1.70229957
154Proximal placement of thumb (HP:0009623)1.70130841
155Abnormality of DNA repair (HP:0003254)1.70069257
156Abnormality of the thoracic spine (HP:0100711)1.69107764
157Abnormality of oral frenula (HP:0000190)1.68950010
158Renal agenesis (HP:0000104)1.68676262
159Ureteral duplication (HP:0000073)1.68443778
160Recurrent bacterial skin infections (HP:0005406)1.68056643
161Rectal prolapse (HP:0002035)1.67756131
162Gastrointestinal inflammation (HP:0004386)1.67472918
163Neoplasm of striated muscle (HP:0009728)1.67466795
164Tracheoesophageal fistula (HP:0002575)1.67337828
165Abnormal trabecular bone morphology (HP:0100671)1.66546757
166Hand muscle atrophy (HP:0009130)1.66090952
167Nonimmune hydrops fetalis (HP:0001790)1.64191436
168Abnormal foot bone ossification (HP:0010675)1.63275722
169Abnormality of glycolipid metabolism (HP:0010969)1.62668729
170Abnormality of liposaccharide metabolism (HP:0010968)1.62668729
171Abnormality of glycosphingolipid metabolism (HP:0004343)1.62668729
172Personality changes (HP:0000751)1.62611656
173Abnormal ossification of hand bones (HP:0005921)1.62045789
174Abnormality of the umbilical cord (HP:0010881)1.61851825
175Sparse lateral eyebrow (HP:0005338)1.60039063
176Hypertriglyceridemia (HP:0002155)1.59732583
177Insomnia (HP:0100785)1.59673085
178Abnormality of aromatic amino acid family metabolism (HP:0004338)1.57903113
179Thin bony cortex (HP:0002753)1.57534476
180Elbow flexion contracture (HP:0002987)1.56750267
181Abnormal gallbladder morphology (HP:0012437)1.56507613
182Generalized amyotrophy (HP:0003700)1.55212285
183Spinal cord lesions (HP:0100561)1.55089866
184Syringomyelia (HP:0003396)1.55089866
185Slow saccadic eye movements (HP:0000514)1.54893631
186Abnormality of the gallbladder (HP:0005264)1.54745668
187Dysostosis multiplex (HP:0000943)1.54529372
188Back pain (HP:0003418)1.54524776
189Stridor (HP:0010307)1.54101434
190Diaphragmatic weakness (HP:0009113)1.53856827
191Lower limb amyotrophy (HP:0007210)1.53489689
192Poikiloderma (HP:0001029)1.52462347
193Cerebral aneurysm (HP:0004944)1.51861560
194Obstructive lung disease (HP:0006536)1.51185686
195Chronic obstructive pulmonary disease (HP:0006510)1.51185686
196Gingivitis (HP:0000230)1.51096839
197Bone pain (HP:0002653)1.50787464
198Abnormality of complement system (HP:0005339)1.50687010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.90132758
2SIK35.63935322
3SIK24.27477593
4CDK124.07178129
5SIK13.99510323
6TRIB33.68379133
7SMG12.98315884
8IRAK32.80421347
9PAK42.65522565
10ERN12.57579344
11MARK32.52840499
12LATS12.45730295
13SRPK12.21161951
14NEK22.13140195
15WEE12.09723345
16CDC72.05172447
17CDK72.02523619
18TTK1.95409133
19RPS6KB21.93317186
20MAP2K31.91226287
21BUB11.88955296
22MST1R1.80336459
23STK38L1.78709962
24BRD41.77321205
25FGFR41.77046782
26LMTK21.63008823
27TTN1.59482526
28MAP3K31.58318144
29ADRBK21.52570884
30CHEK21.52558082
31SCYL21.47547898
32CDK41.46969893
33TESK21.41305918
34TESK11.38428570
35STK41.32202817
36ATR1.31765217
37EEF2K1.31011157
38RIPK11.30841874
39KSR21.24789662
40MAP3K141.23220232
41CDK81.20717559
42STK101.18030850
43ALK1.17245875
44CHEK11.16335069
45RIPK41.16050926
46LATS21.15861445
47ARAF1.13503740
48MAP3K101.09684733
49EPHB11.05991380
50ICK1.03814807
51TBK11.03605665
52ZAK1.03464985
53PLK10.96427077
54PIM10.95807334
55STK30.95525878
56IRAK40.94612493
57MAP3K10.94388486
58PDGFRA0.93534612
59LRRK20.91437126
60MAP4K10.90389309
61PBK0.90018374
62RPS6KA40.89350148
63PTK60.89015753
64NME20.86394767
65PTK20.81661388
66ATM0.80980734
67VRK10.78718520
68EIF2AK10.76358018
69PIM20.75963985
70YES10.74816655
71JAK30.74193675
72TSSK60.74063767
73ZAP700.73612708
74MAP3K80.73066916
75PASK0.72754758
76AURKB0.72214599
77MAPKAPK30.70668422
78PRPF4B0.69818871
79TXK0.69413036
80STK240.68904565
81PDPK10.68390167
82STK380.67409217
83BMX0.66901046
84PDK20.66323441
85AKT30.64601228
86TAOK10.64046503
87PRKG20.63915508
88MAP3K110.61897415
89RAF10.61489756
90MARK20.60100161
91PLK40.59353718
92IRAK20.59186111
93TLK10.59146417
94BLK0.58797322
95CDK20.58337853
96CDC42BPA0.57802652
97MAP3K60.57295782
98MAPK110.57213943
99NEK10.56955503
100BRSK10.54018436
101FGR0.53083336
102AURKA0.52318067
103DYRK30.52303104
104PRKD20.51862908
105MKNK20.51170494
106MTOR0.49871357
107CLK10.49343736
108CDK60.49103029
109MOS0.48169254
110KDR0.47575940
111ACVR1B0.44244186
112* CSNK1D0.44070670
113CDK90.43503325
114TYK20.42801186
115TAOK20.42780674
116ILK0.40939644
117MAPKAPK20.40108236
118FLT30.39971237
119FGFR30.38109770
120MAP2K20.37579297
121GRK60.36867447
122PLK30.36766548
123MAP3K20.35854062
124RPS6KA50.35409426
125CSNK2A10.35099944
126PKN20.34771340
127PRKDC0.34684133
128MET0.33262431
129MELK0.32844626
130TNK20.32195891
131CDK10.32156031
132AKT10.31862817
133* CSNK2A20.30820167
134PRKCI0.27519719
135BRAF0.26019221
136TGFBR10.23989014
137MAPK10.23795841
138MAP3K130.22933292
139MAP3K50.22787948
140CSNK1E0.22349920
141MKNK10.21769478
142HCK0.21768086
143AKT20.21691642
144RPS6KC10.21654647
145RPS6KL10.21654647
146IKBKB0.21292664
147MAPK140.20006774
148PAK10.19461422
149EIF2AK20.19156036
150CSK0.19039337
151GSK3B0.17444844
152CHUK0.17123467
153CSF1R0.17094679

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18667378
2Mismatch repair_Homo sapiens_hsa034303.72615784
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33413921
4One carbon pool by folate_Homo sapiens_hsa006703.14655419
5Homologous recombination_Homo sapiens_hsa034403.05722144
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91810073
7Fanconi anemia pathway_Homo sapiens_hsa034602.66317757
8RNA transport_Homo sapiens_hsa030132.60582494
9Non-homologous end-joining_Homo sapiens_hsa034502.57900373
10* Spliceosome_Homo sapiens_hsa030402.44963823
11Base excision repair_Homo sapiens_hsa034102.39395856
12Cell cycle_Homo sapiens_hsa041102.24368658
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03225977
14Ribosome_Homo sapiens_hsa030101.96463242
15Basal transcription factors_Homo sapiens_hsa030221.94794593
16Nucleotide excision repair_Homo sapiens_hsa034201.92980302
17Notch signaling pathway_Homo sapiens_hsa043301.88141531
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87276691
19Primary immunodeficiency_Homo sapiens_hsa053401.83707267
20RNA polymerase_Homo sapiens_hsa030201.68121375
21p53 signaling pathway_Homo sapiens_hsa041151.63609921
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61019025
23Selenocompound metabolism_Homo sapiens_hsa004501.51771305
24Pyrimidine metabolism_Homo sapiens_hsa002401.51227005
25Lysine degradation_Homo sapiens_hsa003101.50491665
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48415531
27Galactose metabolism_Homo sapiens_hsa000521.48413865
28Non-small cell lung cancer_Homo sapiens_hsa052231.47878065
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.45850277
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45579107
31Thyroid cancer_Homo sapiens_hsa052161.38196454
32mRNA surveillance pathway_Homo sapiens_hsa030151.36860233
33Pancreatic cancer_Homo sapiens_hsa052121.35866830
34Carbon metabolism_Homo sapiens_hsa012001.34012422
35Shigellosis_Homo sapiens_hsa051311.31993091
36Folate biosynthesis_Homo sapiens_hsa007901.28472960
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25008759
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.21610213
39RNA degradation_Homo sapiens_hsa030181.21251941
40B cell receptor signaling pathway_Homo sapiens_hsa046621.20278183
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12166313
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10124317
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.09746890
44HTLV-I infection_Homo sapiens_hsa051661.07755548
45Systemic lupus erythematosus_Homo sapiens_hsa053221.07254631
46MicroRNAs in cancer_Homo sapiens_hsa052061.07074874
47N-Glycan biosynthesis_Homo sapiens_hsa005101.04304879
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03826865
49Mineral absorption_Homo sapiens_hsa049781.02971762
50Herpes simplex infection_Homo sapiens_hsa051681.02180638
51Osteoclast differentiation_Homo sapiens_hsa043801.00197698
52Leishmaniasis_Homo sapiens_hsa051400.94160427
53VEGF signaling pathway_Homo sapiens_hsa043700.94084920
54Legionellosis_Homo sapiens_hsa051340.93136147
55Basal cell carcinoma_Homo sapiens_hsa052170.93128749
56Hepatitis C_Homo sapiens_hsa051600.91171656
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90334746
58Arginine biosynthesis_Homo sapiens_hsa002200.89755233
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89580233
60Endometrial cancer_Homo sapiens_hsa052130.86681549
61Lysosome_Homo sapiens_hsa041420.85075465
62Hematopoietic cell lineage_Homo sapiens_hsa046400.84995203
63Prion diseases_Homo sapiens_hsa050200.83312943
64Insulin signaling pathway_Homo sapiens_hsa049100.82176242
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.81694758
66Small cell lung cancer_Homo sapiens_hsa052220.81217000
67Salmonella infection_Homo sapiens_hsa051320.80565869
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.80422309
69Toxoplasmosis_Homo sapiens_hsa051450.79456376
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78777054
71Vibrio cholerae infection_Homo sapiens_hsa051100.77903137
72Phenylalanine metabolism_Homo sapiens_hsa003600.77133716
73TNF signaling pathway_Homo sapiens_hsa046680.76434927
74Hippo signaling pathway_Homo sapiens_hsa043900.75563950
75Viral carcinogenesis_Homo sapiens_hsa052030.74291783
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.74198682
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73488529
78Biosynthesis of amino acids_Homo sapiens_hsa012300.73410362
79Proteasome_Homo sapiens_hsa030500.72964635
80Measles_Homo sapiens_hsa051620.72795433
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.72486986
82Sulfur relay system_Homo sapiens_hsa041220.72268207
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.71889007
84Epstein-Barr virus infection_Homo sapiens_hsa051690.71745757
85Prostate cancer_Homo sapiens_hsa052150.70924548
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.70076581
87Proteoglycans in cancer_Homo sapiens_hsa052050.69379746
88Viral myocarditis_Homo sapiens_hsa054160.69279885
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66092492
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65434301
91Fructose and mannose metabolism_Homo sapiens_hsa000510.64827797
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64649610
93Purine metabolism_Homo sapiens_hsa002300.64387525
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64350533
95Arginine and proline metabolism_Homo sapiens_hsa003300.63840675
96Adherens junction_Homo sapiens_hsa045200.62424332
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61575376
98Antigen processing and presentation_Homo sapiens_hsa046120.60862607
99Tuberculosis_Homo sapiens_hsa051520.60525435
100Vitamin B6 metabolism_Homo sapiens_hsa007500.60477713
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60293266
102Melanoma_Homo sapiens_hsa052180.60039650
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57660618
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57649415
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.56879134
106Endocytosis_Homo sapiens_hsa041440.56819901
107Acute myeloid leukemia_Homo sapiens_hsa052210.55673475
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.54998851
109Complement and coagulation cascades_Homo sapiens_hsa046100.54411429
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53680683
111Apoptosis_Homo sapiens_hsa042100.53525522
112Hedgehog signaling pathway_Homo sapiens_hsa043400.53444484
113Insulin resistance_Homo sapiens_hsa049310.53117801
114Wnt signaling pathway_Homo sapiens_hsa043100.53043426
115Colorectal cancer_Homo sapiens_hsa052100.51034979
116Glioma_Homo sapiens_hsa052140.50904601
117Chemical carcinogenesis_Homo sapiens_hsa052040.49731675
118Pertussis_Homo sapiens_hsa051330.49448858
119AMPK signaling pathway_Homo sapiens_hsa041520.48770595
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48162793
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46664692
122Pathways in cancer_Homo sapiens_hsa052000.43331739
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42877853
124Bladder cancer_Homo sapiens_hsa052190.41919067
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39818575
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39333149
127T cell receptor signaling pathway_Homo sapiens_hsa046600.39250917
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.38752325
129mTOR signaling pathway_Homo sapiens_hsa041500.38446006
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37587806
131HIF-1 signaling pathway_Homo sapiens_hsa040660.36980143
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36284611
133TGF-beta signaling pathway_Homo sapiens_hsa043500.36262304
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35139590
135Pentose phosphate pathway_Homo sapiens_hsa000300.34324008
136Influenza A_Homo sapiens_hsa051640.31715619
137FoxO signaling pathway_Homo sapiens_hsa040680.29440527
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28791745
139Chronic myeloid leukemia_Homo sapiens_hsa052200.27947938
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27387371
141Hepatitis B_Homo sapiens_hsa051610.25578977
142Glutathione metabolism_Homo sapiens_hsa004800.25578448
143Vitamin digestion and absorption_Homo sapiens_hsa049770.23799239
144Renal cell carcinoma_Homo sapiens_hsa052110.23436318
145Staphylococcus aureus infection_Homo sapiens_hsa051500.23078071
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22751839
147Other glycan degradation_Homo sapiens_hsa005110.21949602
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21623294
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19134007

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