DHX29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.90540980
2nuclear pore organization (GO:0006999)5.77222467
3protein localization to kinetochore (GO:0034501)5.40984788
4folic acid-containing compound biosynthetic process (GO:0009396)4.85401059
5DNA unwinding involved in DNA replication (GO:0006268)4.79681225
6mitotic nuclear envelope disassembly (GO:0007077)4.72404020
7protein localization to chromosome, centromeric region (GO:0071459)4.59068522
8nuclear envelope disassembly (GO:0051081)4.50892631
9membrane disassembly (GO:0030397)4.50892631
10pore complex assembly (GO:0046931)4.48439367
11pre-miRNA processing (GO:0031054)4.43129753
12mitotic metaphase plate congression (GO:0007080)4.33773689
13DNA replication-dependent nucleosome organization (GO:0034723)4.29034509
14DNA replication-dependent nucleosome assembly (GO:0006335)4.29034509
15establishment of integrated proviral latency (GO:0075713)4.15674675
16regulation of RNA export from nucleus (GO:0046831)4.13572320
17mitotic chromosome condensation (GO:0007076)4.08065444
18synapsis (GO:0007129)4.07532750
19IMP biosynthetic process (GO:0006188)4.04952353
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04593254
21regulation of translational termination (GO:0006449)4.03938087
22positive regulation of chromosome segregation (GO:0051984)4.01738775
23regulation of spindle organization (GO:0090224)3.99916642
24sister chromatid segregation (GO:0000819)3.98380605
25proteasome assembly (GO:0043248)3.95428288
26mitotic sister chromatid cohesion (GO:0007064)3.94874983
27mitotic sister chromatid segregation (GO:0000070)3.92910431
28nucleobase biosynthetic process (GO:0046112)3.89274546
29histone H2A monoubiquitination (GO:0035518)3.87520247
30regulation of translational fidelity (GO:0006450)3.85541227
31negative regulation of histone methylation (GO:0031061)3.85215690
32DNA double-strand break processing (GO:0000729)3.80020996
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78327412
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78327412
35positive regulation of mitotic sister chromatid separation (GO:1901970)3.78327412
36regulation of mitotic spindle organization (GO:0060236)3.78219738
37DNA duplex unwinding (GO:0032508)3.75943172
38DNA geometric change (GO:0032392)3.73030254
39histone-serine phosphorylation (GO:0035404)3.70731553
40metaphase plate congression (GO:0051310)3.69115211
41heterochromatin organization (GO:0070828)3.68347444
42IMP metabolic process (GO:0046040)3.65402207
43ribosome assembly (GO:0042255)3.63003083
44purine nucleobase biosynthetic process (GO:0009113)3.61063493
45nuclear envelope organization (GO:0006998)3.59296069
46regulation of posttranscriptional gene silencing (GO:0060147)3.57550238
47regulation of gene silencing by miRNA (GO:0060964)3.57550238
48regulation of gene silencing by RNA (GO:0060966)3.57550238
49protein localization to chromosome (GO:0034502)3.53683790
50regulation of sister chromatid cohesion (GO:0007063)3.53192487
51DNA ligation (GO:0006266)3.50340657
52formation of translation preinitiation complex (GO:0001731)3.48817592
53DNA replication initiation (GO:0006270)3.48375067
54regulation of histone H3-K9 methylation (GO:0051570)3.48209963
55regulation of chromosome segregation (GO:0051983)3.40550851
56non-recombinational repair (GO:0000726)3.37671463
57double-strand break repair via nonhomologous end joining (GO:0006303)3.37671463
58DNA replication checkpoint (GO:0000076)3.34530106
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28482666
60regulation of centrosome cycle (GO:0046605)3.28350104
61DNA strand elongation involved in DNA replication (GO:0006271)3.28141029
62regulation of centriole replication (GO:0046599)3.26738012
63establishment of chromosome localization (GO:0051303)3.25674767
64positive regulation of SMAD protein import into nucleus (GO:0060391)3.25312798
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21163554
66spindle checkpoint (GO:0031577)3.18689506
67negative regulation of chromosome segregation (GO:0051985)3.18347994
68attachment of spindle microtubules to kinetochore (GO:0008608)3.15333244
69regulation of nucleobase-containing compound transport (GO:0032239)3.15130077
70chaperone-mediated protein complex assembly (GO:0051131)3.13614999
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12657515
72regulation of mitotic spindle checkpoint (GO:1903504)3.12657515
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12248894
74negative regulation of sister chromatid segregation (GO:0033046)3.12248894
75negative regulation of mitotic sister chromatid separation (GO:2000816)3.12248894
76negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12248894
77resolution of meiotic recombination intermediates (GO:0000712)3.11894073
78chromatin assembly or disassembly (GO:0006333)3.11740337
79DNA conformation change (GO:0071103)3.10295726
80mitotic spindle checkpoint (GO:0071174)3.10129938
81kinetochore organization (GO:0051383)3.09938499
82chromatin assembly (GO:0031497)3.08432961
83regulation of sister chromatid segregation (GO:0033045)3.07540880
84regulation of mitotic sister chromatid separation (GO:0010965)3.07540880
85regulation of mitotic sister chromatid segregation (GO:0033047)3.07540880
86spindle assembly checkpoint (GO:0071173)3.06738913
87mitotic spindle assembly checkpoint (GO:0007094)3.06271484
88DNA strand elongation (GO:0022616)3.06159607
89DNA replication-independent nucleosome assembly (GO:0006336)3.05795490
90DNA replication-independent nucleosome organization (GO:0034724)3.05795490
91chromosome condensation (GO:0030261)3.05409937
92regulation of DNA endoreduplication (GO:0032875)3.04780933
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03254565
94chromatin remodeling at centromere (GO:0031055)3.02197653
95folic acid metabolic process (GO:0046655)2.99436826
96regulation of helicase activity (GO:0051095)2.97935885
97dosage compensation (GO:0007549)2.94726902
98glucocorticoid receptor signaling pathway (GO:0042921)2.93712270
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91105100
100ribosome biogenesis (GO:0042254)2.89339001
101ATP-dependent chromatin remodeling (GO:0043044)2.88809434
102monoubiquitinated protein deubiquitination (GO:0035520)2.87935440
103DNA damage response, detection of DNA damage (GO:0042769)2.87743426
104histone mRNA metabolic process (GO:0008334)2.87732573
105histone exchange (GO:0043486)2.87634592
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86258314
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.86258314
108peptidyl-arginine omega-N-methylation (GO:0035247)2.85964921
109mRNA transport (GO:0051028)2.85637221
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.85606835
111DNA packaging (GO:0006323)2.84698712
112NLS-bearing protein import into nucleus (GO:0006607)2.84651258
113chromosome segregation (GO:0007059)2.83946784
114CENP-A containing nucleosome assembly (GO:0034080)2.83823699
115regulation of telomere maintenance via telomerase (GO:0032210)2.83587539
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83569378
117establishment of viral latency (GO:0019043)2.83063774
118paraxial mesoderm development (GO:0048339)2.82541038
119mitotic G2/M transition checkpoint (GO:0044818)2.82293299
120gene silencing by RNA (GO:0031047)2.82223761
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79392519
122sister chromatid cohesion (GO:0007062)2.78058779
123cullin deneddylation (GO:0010388)2.77492535
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77407157
125telomere maintenance via telomerase (GO:0007004)2.77199003
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74982288
127DNA catabolic process, exonucleolytic (GO:0000738)2.73842724
128regulation of centrosome duplication (GO:0010824)2.73331342
129response to X-ray (GO:0010165)2.71367546
130tRNA aminoacylation (GO:0043039)2.68212334
131amino acid activation (GO:0043038)2.68212334
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68080691
133negative regulation of DNA recombination (GO:0045910)2.68069663
134ventricular cardiac muscle cell development (GO:0055015)2.67562875
135tRNA aminoacylation for protein translation (GO:0006418)2.67545298
136chromosome organization involved in meiosis (GO:0070192)2.67145774
137RNA-dependent DNA replication (GO:0006278)2.63787386
138regulation of meiosis I (GO:0060631)2.62586658
139kinetochore assembly (GO:0051382)2.61092152
140maturation of 5.8S rRNA (GO:0000460)2.60500692
141postreplication repair (GO:0006301)2.59240040
142somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58987037
143isotype switching (GO:0045190)2.58987037
144somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58987037
145negative regulation of DNA repair (GO:0045738)2.58883099
146protein K6-linked ubiquitination (GO:0085020)2.58300772
147negative regulation of fibroblast apoptotic process (GO:2000270)2.54949552
148negative regulation of ligase activity (GO:0051352)2.53948785
149negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53948785
150mitotic spindle organization (GO:0007052)2.52131046
151negative regulation of mitosis (GO:0045839)2.50534489
152protein deneddylation (GO:0000338)2.48423170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42350528
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.27961380
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91297235
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.89792299
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.36104675
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17411932
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10679329
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95789102
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78203508
10AR_21909140_ChIP-Seq_LNCAP_Human2.69200519
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52537127
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37568120
13FUS_26573619_Chip-Seq_HEK293_Human2.29453173
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.27196820
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22549712
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18990243
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.18054393
18MYC_22102868_ChIP-Seq_BL_Human2.15994475
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14178409
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12994482
21XRN2_22483619_ChIP-Seq_HELA_Human2.06883981
22EWS_26573619_Chip-Seq_HEK293_Human2.05786041
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04632645
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00498867
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97704408
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90022316
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89376915
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.85763479
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.85324092
30IGF1R_20145208_ChIP-Seq_DFB_Human1.81834954
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78803056
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78368396
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76601858
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76178330
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74817672
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74177421
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72238528
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70258164
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68690541
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.65973177
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65817335
42CIITA_25753668_ChIP-Seq_RAJI_Human1.64426818
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63372527
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63223618
45KDM5A_27292631_Chip-Seq_BREAST_Human1.61368708
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59000129
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53808453
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51867921
49TAF15_26573619_Chip-Seq_HEK293_Human1.51452967
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51243015
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50692346
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50674857
53VDR_23849224_ChIP-Seq_CD4+_Human1.45936588
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.43413651
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.41907259
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41528316
57GABP_19822575_ChIP-Seq_HepG2_Human1.40298016
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38980876
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38645306
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38531586
61* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38519928
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37080881
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36885631
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36471514
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35924487
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35484643
67TTF2_22483619_ChIP-Seq_HELA_Human1.35426596
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35230337
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35005038
70MYC_18940864_ChIP-ChIP_HL60_Human1.34851142
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33082135
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31612682
73P300_19829295_ChIP-Seq_ESCs_Human1.31276961
74DCP1A_22483619_ChIP-Seq_HELA_Human1.29063735
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.28448319
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28082077
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27096920
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27053694
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26255087
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24251603
81* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22474252
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21472003
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.20864250
84VDR_22108803_ChIP-Seq_LS180_Human1.20021843
85TFEB_21752829_ChIP-Seq_HELA_Human1.20011178
86ZNF274_21170338_ChIP-Seq_K562_Hela1.20008158
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19203503
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18626961
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18573816
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18482976
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18482976
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18482976
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.17657199
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16883887
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15311529
96ZNF263_19887448_ChIP-Seq_K562_Human1.15233185
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.14769553
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13264712
99CHD1_26751641_Chip-Seq_LNCaP_Human1.12661085
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12227806
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11110741
102ELK1_19687146_ChIP-ChIP_HELA_Human1.10956284
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.09557109
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09433155
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09058421
106BRD4_25478319_ChIP-Seq_HGPS_Human1.08317932
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08171777
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05948869
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.05363850
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03970518
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03613417
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.02674599
113GBX2_23144817_ChIP-Seq_PC3_Human1.01146862
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00797414
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99873291
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99718987
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98894052
118CLOCK_20551151_ChIP-Seq_293T_Human0.98191475
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97888940
120ATF3_27146783_Chip-Seq_COLON_Human0.96131907
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.95921363
122CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94207662
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93347021
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93086276
125CBP_20019798_ChIP-Seq_JUKART_Human0.93086276
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92522886
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92384830
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.92297930
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.92001650
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90903382
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90834084
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89713197
133ER_23166858_ChIP-Seq_MCF-7_Human0.89548978
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89386226
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89016770
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88637174
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.88428238
138SMAD4_21799915_ChIP-Seq_A2780_Human0.88122094
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87486563
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.87171718
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86984481
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86726006
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86261374
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86237737
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86051192
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84918004
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84420138
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.83718496
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.83103921
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82000653
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81997886
152PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81471046
153SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81434598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.86869150
2MP0004957_abnormal_blastocyst_morpholog3.79533632
3MP0010094_abnormal_chromosome_stability3.72827400
4MP0003693_abnormal_embryo_hatching3.71236547
5MP0010352_gastrointestinal_tract_polyps3.57549701
6MP0003077_abnormal_cell_cycle3.31368353
7MP0003705_abnormal_hypodermis_morpholog3.29605910
8MP0003123_paternal_imprinting3.02833784
9MP0008057_abnormal_DNA_replication2.90868885
10MP0001730_embryonic_growth_arrest2.72909506
11MP0009697_abnormal_copulation2.49920095
12MP0008007_abnormal_cellular_replicative2.41324740
13MP0010307_abnormal_tumor_latency2.35830303
14MP0000350_abnormal_cell_proliferation2.34241716
15MP0005076_abnormal_cell_differentiation2.33810496
16MP0001672_abnormal_embryogenesis/_devel2.11137851
17MP0005380_embryogenesis_phenotype2.11137851
18MP0008877_abnormal_DNA_methylation2.10868392
19MP0008932_abnormal_embryonic_tissue2.07124146
20MP0002084_abnormal_developmental_patter2.03440388
21MP0001697_abnormal_embryo_size1.99162677
22MP0003984_embryonic_growth_retardation1.96251368
23MP0000537_abnormal_urethra_morphology1.93674237
24MP0002088_abnormal_embryonic_growth/wei1.93365450
25MP0004197_abnormal_fetal_growth/weight/1.91464433
26MP0002085_abnormal_embryonic_tissue1.90891307
27MP0001188_hyperpigmentation1.89635057
28MP0008058_abnormal_DNA_repair1.88543241
29MP0009053_abnormal_anal_canal1.81279403
30MP0002086_abnormal_extraembryonic_tissu1.78019065
31MP0002080_prenatal_lethality1.75457463
32MP0003890_abnormal_embryonic-extraembry1.68791053
33MP0003186_abnormal_redox_activity1.68309108
34MP0003121_genomic_imprinting1.64427329
35MP0003566_abnormal_cell_adhesion1.60819436
36MP0010030_abnormal_orbit_morphology1.59930882
37MP0003567_abnormal_fetal_cardiomyocyte1.48006465
38MP0003950_abnormal_plasma_membrane1.45070331
39MP0003119_abnormal_digestive_system1.43176328
40MP0004272_abnormal_basement_membrane1.38991679
41MP0009672_abnormal_birth_weight1.36168651
42MP0002233_abnormal_nose_morphology1.35728620
43MP0006292_abnormal_olfactory_placode1.34795726
44MP0000733_abnormal_muscle_development1.33852884
45MP0002396_abnormal_hematopoietic_system1.32921169
46MP0002160_abnormal_reproductive_system1.32198012
47MP0004185_abnormal_adipocyte_glucose1.30916891
48MP0004233_abnormal_muscle_weight1.29692298
49MP0002653_abnormal_ependyma_morphology1.28634403
50MP0010234_abnormal_vibrissa_follicle1.28049842
51MP0001529_abnormal_vocalization1.27718436
52MP0009703_decreased_birth_body1.23895179
53MP0000516_abnormal_urinary_system1.23408003
54MP0005367_renal/urinary_system_phenotyp1.23408003
55MP0002877_abnormal_melanocyte_morpholog1.22333097
56MP0006072_abnormal_retinal_apoptosis1.20937278
57MP0000569_abnormal_digit_pigmentation1.20636555
58MP0001293_anophthalmia1.20365894
59MP0010368_abnormal_lymphatic_system1.19600189
60MP0008789_abnormal_olfactory_epithelium1.17443275
61MP0002269_muscular_atrophy1.17035278
62MP0005275_abnormal_skin_tensile1.16872671
63MP0005023_abnormal_wound_healing1.11746805
64MP0001849_ear_inflammation1.11648267
65MP0008438_abnormal_cutaneous_collagen1.10072909
66MP0000428_abnormal_craniofacial_morphol1.09063965
67MP0004215_abnormal_myocardial_fiber1.08803469
68MP0002938_white_spotting1.07147621
69MP0003937_abnormal_limbs/digits/tail_de1.06053898
70MP0000313_abnormal_cell_death1.05727106
71MP0003221_abnormal_cardiomyocyte_apopto1.05610090
72MP0003806_abnormal_nucleotide_metabolis1.02276574
73MP0002177_abnormal_outer_ear1.01987812
74MP0004808_abnormal_hematopoietic_stem1.01849957
75MP0001879_abnormal_lymphatic_vessel1.01593353
76MP0005187_abnormal_penis_morphology1.00031206
77MP0009250_abnormal_appendicular_skeleto0.99824215
78MP0000647_abnormal_sebaceous_gland0.99653846
79MP0001915_intracranial_hemorrhage0.99621669
80MP0004084_abnormal_cardiac_muscle0.99540567
81MP0001177_atelectasis0.96883119
82MP0002697_abnormal_eye_size0.96815642
83MP0000750_abnormal_muscle_regeneration0.96756792
84MP0002111_abnormal_tail_morphology0.96501784
85MP0006035_abnormal_mitochondrial_morpho0.95856231
86MP0005623_abnormal_meninges_morphology0.94746871
87MP0000762_abnormal_tongue_morphology0.92871009
88MP0002019_abnormal_tumor_incidence0.92476584
89MP0001984_abnormal_olfaction0.91700689
90MP0000427_abnormal_hair_cycle0.90296064
91MP0005621_abnormal_cell_physiology0.89112559
92MP0002925_abnormal_cardiovascular_devel0.88942725
93MP0002210_abnormal_sex_determination0.88302559
94MP0003935_abnormal_craniofacial_develop0.87020533
95MP0003115_abnormal_respiratory_system0.86610165
96MP0005384_cellular_phenotype0.86453132
97MP0000749_muscle_degeneration0.86237097
98MP0001145_abnormal_male_reproductive0.85748469
99MP0000747_muscle_weakness0.84418422
100MP0003941_abnormal_skin_development0.84135033
101MP0004087_abnormal_muscle_fiber0.83891678
102MP0000358_abnormal_cell_content/0.83752270
103MP0003091_abnormal_cell_migration0.83565269
104MP0002092_abnormal_eye_morphology0.83204108
105MP0000490_abnormal_crypts_of0.83186718
106MP0002234_abnormal_pharynx_morphology0.81806251
107MP0003786_premature_aging0.81805334
108MP0005666_abnormal_adipose_tissue0.80400442
109MP0000266_abnormal_heart_morphology0.80181909
110MP0000049_abnormal_middle_ear0.80035671
111MP0003718_maternal_effect0.79633560
112MP0000432_abnormal_head_morphology0.79592607
113MP0003861_abnormal_nervous_system0.78641028
114MP0003283_abnormal_digestive_organ0.78342014
115MP0001661_extended_life_span0.78263115
116MP0005395_other_phenotype0.77433834
117MP0006054_spinal_hemorrhage0.77130863
118MP0010630_abnormal_cardiac_muscle0.76016332
119MP0004134_abnormal_chest_morphology0.75830639
120MP0000579_abnormal_nail_morphology0.75817570
121MP0003787_abnormal_imprinting0.75558545
122MP0001348_abnormal_lacrimal_gland0.75543980
123MP0000653_abnormal_sex_gland0.73873033
124MP0001929_abnormal_gametogenesis0.73638417
125MP0000372_irregular_coat_pigmentation0.72579940
126MP0005389_reproductive_system_phenotype0.71761763
127MP0002102_abnormal_ear_morphology0.71742020
128MP0005501_abnormal_skin_physiology0.71539012
129MP0008770_decreased_survivor_rate0.70585264
130MP0003315_abnormal_perineum_morphology0.70563297
131MP0002751_abnormal_autonomic_nervous0.70497981
132MP0001958_emphysema0.70380563
133MP0001299_abnormal_eye_distance/0.69002465
134MP0003385_abnormal_body_wall0.68948761
135MP0003755_abnormal_palate_morphology0.68898307
136MP0005503_abnormal_tendon_morphology0.67272064
137MP0001286_abnormal_eye_development0.66515815
138MP0002796_impaired_skin_barrier0.65468178
139MP0003300_gastrointestinal_ulcer0.63133997
140MP0005375_adipose_tissue_phenotype0.62271005
141MP0000703_abnormal_thymus_morphology0.61733661

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.04173974
2Selective tooth agenesis (HP:0001592)3.39488674
3Colon cancer (HP:0003003)3.34714845
4Abnormality of chromosome stability (HP:0003220)3.29344400
5Astrocytoma (HP:0009592)3.23128193
6Abnormality of the astrocytes (HP:0100707)3.23128193
7Abnormality of the labia minora (HP:0012880)3.05038872
8Birth length less than 3rd percentile (HP:0003561)2.93386600
9Rhabdomyosarcoma (HP:0002859)2.92477114
10Medulloblastoma (HP:0002885)2.82322084
11Biliary tract neoplasm (HP:0100574)2.73531674
12Deviation of the thumb (HP:0009603)2.71740592
13Short 4th metacarpal (HP:0010044)2.71444190
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71444190
15Abnormality of the lower motor neuron (HP:0002366)2.69096115
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68997683
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.64002507
18Degeneration of anterior horn cells (HP:0002398)2.63974771
19Abnormality of the anterior horn cell (HP:0006802)2.63974771
20Proximal placement of thumb (HP:0009623)2.61935624
21Cortical dysplasia (HP:0002539)2.58931801
22Pelvic girdle muscle weakness (HP:0003749)2.56091067
23Abnormal lung lobation (HP:0002101)2.55995603
24Meckel diverticulum (HP:0002245)2.54140811
25Neoplasm of striated muscle (HP:0009728)2.52192286
26Glioma (HP:0009733)2.48788128
27Abnormality of the preputium (HP:0100587)2.46444701
28Missing ribs (HP:0000921)2.45909085
29Shallow orbits (HP:0000586)2.41015323
30Angiofibromas (HP:0010615)2.39177594
31Adenoma sebaceum (HP:0009720)2.39177594
32Shoulder girdle muscle weakness (HP:0003547)2.38105014
33Abnormality of the ileum (HP:0001549)2.36958064
34Increased hepatocellular lipid droplets (HP:0006565)2.36850450
35Embryonal renal neoplasm (HP:0011794)2.35982449
36Breast hypoplasia (HP:0003187)2.35033989
37Patellar aplasia (HP:0006443)2.33815472
38Basal cell carcinoma (HP:0002671)2.31887839
39Carpal bone hypoplasia (HP:0001498)2.29846683
40Shawl scrotum (HP:0000049)2.29189824
41Lipid accumulation in hepatocytes (HP:0006561)2.27998251
42Increased nuchal translucency (HP:0010880)2.27663014
43Gastrointestinal carcinoma (HP:0002672)2.26530432
44Malignant gastrointestinal tract tumors (HP:0006749)2.26530432
45Abnormality of the calcaneus (HP:0008364)2.26416860
46Nephroblastoma (Wilms tumor) (HP:0002667)2.24946621
47Small intestinal stenosis (HP:0012848)2.22027283
48Duodenal stenosis (HP:0100867)2.22027283
49Impulsivity (HP:0100710)2.21853357
50Neoplasm of the oral cavity (HP:0100649)2.21027187
51Sandal gap (HP:0001852)2.20032344
52Increased density of long bones (HP:0006392)2.19372017
53Aplasia/Hypoplasia of the patella (HP:0006498)2.17646949
54Abnormality of the musculature of the pelvis (HP:0001469)2.17492140
55Abnormality of the hip-girdle musculature (HP:0001445)2.17492140
56Abnormality of the 4th metacarpal (HP:0010012)2.17082375
57Ankle contracture (HP:0006466)2.14429861
58Genu recurvatum (HP:0002816)2.12467959
59Thyroid carcinoma (HP:0002890)2.11788310
60Volvulus (HP:0002580)2.11585544
61Overlapping toe (HP:0001845)2.10614811
62Acute necrotizing encephalopathy (HP:0006965)2.09578986
63Spinal muscular atrophy (HP:0007269)2.09024326
64Rectal prolapse (HP:0002035)2.08947371
65Facial hemangioma (HP:0000329)2.07184420
66Wrist flexion contracture (HP:0001239)2.04444340
67Protrusio acetabuli (HP:0003179)2.03104471
68Cerebral aneurysm (HP:0004944)2.03040688
69Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.02397129
70Short 1st metacarpal (HP:0010034)2.02397129
71Oral leukoplakia (HP:0002745)2.02097433
72Increased serum pyruvate (HP:0003542)2.01328419
73Intestinal polyp (HP:0005266)2.00529942
74Hand muscle atrophy (HP:0009130)1.99462840
75Intestinal polyposis (HP:0200008)1.99187178
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.99031674
77Cafe-au-lait spot (HP:0000957)1.98982957
78High pitched voice (HP:0001620)1.98312832
79Neoplasm of the small intestine (HP:0100833)1.97359427
80Agnosia (HP:0010524)1.97299881
81Atrophy/Degeneration involving motor neurons (HP:0007373)1.97111055
82Pseudobulbar signs (HP:0002200)1.96905311
83Abnormality of the duodenum (HP:0002246)1.96564132
84Aplasia/hypoplasia of the humerus (HP:0006507)1.95553491
85Abnormal biliary tract morphology (HP:0012440)1.95308704
86Fibroma (HP:0010614)1.94109750
87Uterine neoplasm (HP:0010784)1.92684615
88Neoplasm of the rectum (HP:0100743)1.90906973
89Achilles tendon contracture (HP:0001771)1.89977050
90Broad thumb (HP:0011304)1.89934852
91Nemaline bodies (HP:0003798)1.89283028
92Fibrous tissue neoplasm (HP:0012316)1.88840254
93Progressive macrocephaly (HP:0004481)1.88674824
94Spastic diplegia (HP:0001264)1.88634807
95Neoplasm of the pancreas (HP:0002894)1.88267344
96Heterotopia (HP:0002282)1.87828598
97Short humerus (HP:0005792)1.87813555
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87306436
99Short middle phalanx of the 5th finger (HP:0004220)1.86891133
100Acute encephalopathy (HP:0006846)1.86740950
101Small hand (HP:0200055)1.86722270
102Prominent nose (HP:0000448)1.86336256
103Myelodysplasia (HP:0002863)1.85157297
104Atresia of the external auditory canal (HP:0000413)1.84525910
105Bifid tongue (HP:0010297)1.83260981
106Metaphyseal cupping (HP:0003021)1.82643826
107Broad phalanges of the hand (HP:0009768)1.82476359
108Gonadotropin excess (HP:0000837)1.82128926
109Difficulty climbing stairs (HP:0003551)1.81554355
110Papillary thyroid carcinoma (HP:0002895)1.81068807
111Neoplasm of the colon (HP:0100273)1.80137335
112Sloping forehead (HP:0000340)1.79736427
113Multiple enchondromatosis (HP:0005701)1.79055672
114Rimmed vacuoles (HP:0003805)1.78919971
115Reduced antithrombin III activity (HP:0001976)1.78495994
116Increased CSF lactate (HP:0002490)1.77486420
117Horizontal nystagmus (HP:0000666)1.76487957
118Long eyelashes (HP:0000527)1.76193040
119Muscle fiber inclusion bodies (HP:0100299)1.75860225
120Ovarian neoplasm (HP:0100615)1.75530276
121Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74808739
122Stillbirth (HP:0003826)1.74507682
123Hypoplastic labia majora (HP:0000059)1.74253339
124Abnormality of the fingertips (HP:0001211)1.74248863
125Abnormality of methionine metabolism (HP:0010901)1.74237674
126Skin tags (HP:0010609)1.74124458
127Microglossia (HP:0000171)1.73673693
128Chromsome breakage (HP:0040012)1.73049426
129Broad palm (HP:0001169)1.71838828
130Increased connective tissue (HP:0009025)1.71444632
131Abnormal mitochondria in muscle tissue (HP:0008316)1.70433615
132Abnormal number of incisors (HP:0011064)1.70121100
133Cutaneous melanoma (HP:0012056)1.69114305
134Back pain (HP:0003418)1.69059737
135Abnormality of the Achilles tendon (HP:0005109)1.68998084
136Trismus (HP:0000211)1.68764269
137Chronic hepatic failure (HP:0100626)1.68286196
138Vertebral arch anomaly (HP:0008438)1.67979811
139Distal upper limb amyotrophy (HP:0007149)1.67301127
140Hyperglycinemia (HP:0002154)1.64663980
141Arteriovenous malformation (HP:0100026)1.64578104
142Abnormality of glycolysis (HP:0004366)1.61319585
143Mitochondrial inheritance (HP:0001427)1.61065811
144Cerebral edema (HP:0002181)1.60738027
145Exercise-induced muscle cramps (HP:0003710)1.60108294
146Redundant skin (HP:0001582)1.60020380
147Type I transferrin isoform profile (HP:0003642)1.59398956
148Limb-girdle muscle weakness (HP:0003325)1.59394727
149Renal cortical cysts (HP:0000803)1.59006621
150Abnormality of the carotid arteries (HP:0005344)1.57915203
151Renal Fanconi syndrome (HP:0001994)1.56594996
152Deep philtrum (HP:0002002)1.55479259
153Short tibia (HP:0005736)1.52858027
154Azoospermia (HP:0000027)1.52665886
155Abnormality of the labia majora (HP:0012881)1.52509717
156Acute myeloid leukemia (HP:0004808)1.50629875
157Premature rupture of membranes (HP:0001788)1.49809150
158Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.49458430
159Neoplasm of the peripheral nervous system (HP:0100007)1.48638393
160Abnormality of renal resorption (HP:0011038)1.47722667
161Facial cleft (HP:0002006)1.47039529
162Increased serum lactate (HP:0002151)1.46366419
163Progressive external ophthalmoplegia (HP:0000590)1.45179199
164Central scotoma (HP:0000603)1.44848615
165Ectopic kidney (HP:0000086)1.43904360
166Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.43640900
167Abnormal protein N-linked glycosylation (HP:0012347)1.43640900
168Abnormal protein glycosylation (HP:0012346)1.43640900
169Abnormal glycosylation (HP:0012345)1.43640900
170Hypoglycemic seizures (HP:0002173)1.43287870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.23397107
2CDK123.21914628
3WEE13.05950450
4BUB12.69064787
5NEK22.60498915
6STK162.54781068
7PBK2.54095681
8TTK2.44888227
9NEK12.41230345
10EEF2K2.28475401
11PKN22.11466103
12TRIB32.10865906
13TSSK62.07189246
14ERBB32.04674802
15MST42.03843609
16SCYL22.03124956
17EIF2AK11.96368804
18SRPK11.92684567
19MAP3K101.92580387
20BRSK21.89928500
21LATS11.75672797
22TTN1.74316155
23LATS21.71579885
24STK101.70236236
25WNK31.69408702
26MAP3K121.68061895
27PLK11.67379289
28TRIM281.66763908
29RPS6KB21.63867528
30BCR1.63808641
31PLK31.63249982
32NUAK11.58009546
33ALK1.52113004
34PASK1.49154841
35MAP3K81.42971962
36CHEK11.42141434
37ATR1.40084218
38CDK41.39639347
39BMPR1B1.38722970
40TNIK1.37103354
41AURKB1.34980623
42STK38L1.31059099
43CDK71.30786530
44CASK1.30603848
45CCNB11.26237244
46STK31.24326118
47CHEK21.20199478
48TAF11.19676876
49PNCK1.17464750
50MTOR1.15833708
51ACVR1B1.15095294
52PRKD31.14495582
53TESK21.08489889
54CDK61.05663677
55PLK41.05086142
56OBSCN1.02514999
57CDK21.02451659
58MKNK11.02282322
59MAP3K41.01592714
60EPHA21.00902368
61PDK41.00636335
62PDK31.00636335
63TGFBR10.99436098
64BRSK10.98544973
65ATM0.98390740
66PDGFRA0.97309627
67EIF2AK20.95617947
68MELK0.93368159
69RPS6KA40.91847995
70AKT30.91762100
71FGFR10.91672531
72PAK40.90976629
73DMPK0.88916010
74KSR10.88322431
75PTK60.87155428
76LRRK20.87090655
77TIE10.86141397
78MYLK0.85669693
79AURKA0.85122839
80STK390.84836874
81PLK20.82686060
82CSNK1G10.78401484
83MAP2K70.77938657
84BRD40.77355851
85* CDK10.77085568
86VRK20.75012856
87FLT30.74668244
88MKNK20.72752212
89CSNK1E0.71577788
90PINK10.70964715
91TESK10.70241489
92STK40.68320972
93TEC0.67207448
94LIMK10.67183797
95CAMK1D0.66477991
96EIF2AK30.64993500
97PDK20.64835760
98PAK20.63775250
99TLK10.60876208
100NEK90.60640088
101CLK10.60637121
102MET0.60283934
103PIK3CG0.58513343
104CSNK2A20.54051405
105MST1R0.53892351
106PRKDC0.52774212
107PRKCE0.52606920
108PAK10.51851417
109CSNK1D0.51215766
110MAP4K20.49968952
111CDK30.49430648
112NME10.49007574
113KSR20.48084645
114FRK0.47452727
115DYRK30.45983977
116CSNK1G20.44279217
117CSNK1G30.41374269
118BMX0.41321820
119PIM10.40891447
120STK240.40087830
121AKT20.39890557
122MAPK140.39295394
123PAK30.38196165
124MAP3K90.38104294
125CSNK2A10.37224510
126RAF10.36947898
127ERBB40.35804447
128GSK3B0.35683278
129PRKCI0.34661323
130ZAK0.34496348
131BRAF0.34468482
132DDR20.34439434
133PRKACB0.33936100
134CSNK1A1L0.33343110
135VRK10.32732324
136CDK90.32369068
137PRKAA10.29873380
138MAPK10.29614072
139CAMK1G0.29472843
140ILK0.29169176
141MAPK100.28894482
142AKT10.28329249
143MAP3K50.27835290
144RIPK10.27538960
145BMPR20.25907853

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63693080
2RNA transport_Homo sapiens_hsa030133.58381042
3DNA replication_Homo sapiens_hsa030303.57871168
4One carbon pool by folate_Homo sapiens_hsa006703.27438181
5Mismatch repair_Homo sapiens_hsa034303.17863286
6Protein export_Homo sapiens_hsa030603.13498963
7Cell cycle_Homo sapiens_hsa041103.01222291
8Spliceosome_Homo sapiens_hsa030402.94755596
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89247358
10mRNA surveillance pathway_Homo sapiens_hsa030152.37425143
11RNA polymerase_Homo sapiens_hsa030202.19076477
12Base excision repair_Homo sapiens_hsa034102.19021072
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05351867
14Propanoate metabolism_Homo sapiens_hsa006401.98204438
15Nucleotide excision repair_Homo sapiens_hsa034201.93625696
16Homologous recombination_Homo sapiens_hsa034401.89293265
17Non-homologous end-joining_Homo sapiens_hsa034501.79081481
18p53 signaling pathway_Homo sapiens_hsa041151.71669270
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69356161
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69243728
21RNA degradation_Homo sapiens_hsa030181.66594861
22Selenocompound metabolism_Homo sapiens_hsa004501.55203421
23Oocyte meiosis_Homo sapiens_hsa041141.51274548
24Viral carcinogenesis_Homo sapiens_hsa052031.50130975
25Oxidative phosphorylation_Homo sapiens_hsa001901.48799021
26Proteasome_Homo sapiens_hsa030501.45945959
27mTOR signaling pathway_Homo sapiens_hsa041501.42441153
28Steroid biosynthesis_Homo sapiens_hsa001001.41397586
29Parkinsons disease_Homo sapiens_hsa050121.38755227
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37442300
31Biosynthesis of amino acids_Homo sapiens_hsa012301.37144568
32MicroRNAs in cancer_Homo sapiens_hsa052061.37073138
33Systemic lupus erythematosus_Homo sapiens_hsa053221.33284669
34Pyrimidine metabolism_Homo sapiens_hsa002401.31244366
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.24032487
36Epstein-Barr virus infection_Homo sapiens_hsa051691.20925112
37Fanconi anemia pathway_Homo sapiens_hsa034601.20599191
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18824219
39Adherens junction_Homo sapiens_hsa045201.18036114
40Basal transcription factors_Homo sapiens_hsa030221.17327619
41Huntingtons disease_Homo sapiens_hsa050161.16157018
42Hippo signaling pathway_Homo sapiens_hsa043901.13926191
43Small cell lung cancer_Homo sapiens_hsa052221.11137167
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09829484
45Colorectal cancer_Homo sapiens_hsa052101.09019777
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.08580169
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08483330
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06967591
49Carbon metabolism_Homo sapiens_hsa012001.05040726
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03618219
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03494306
52Fatty acid elongation_Homo sapiens_hsa000621.03338737
53Butanoate metabolism_Homo sapiens_hsa006501.02027523
54Lysine degradation_Homo sapiens_hsa003101.01746234
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01671203
56Chronic myeloid leukemia_Homo sapiens_hsa052201.01363171
57TGF-beta signaling pathway_Homo sapiens_hsa043501.01311909
58HTLV-I infection_Homo sapiens_hsa051660.96188631
59Antigen processing and presentation_Homo sapiens_hsa046120.94843391
60Thyroid cancer_Homo sapiens_hsa052160.93656442
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93107261
62Regulation of autophagy_Homo sapiens_hsa041400.91078533
63Circadian rhythm_Homo sapiens_hsa047100.88950141
64Viral myocarditis_Homo sapiens_hsa054160.88276408
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88248826
66Sulfur metabolism_Homo sapiens_hsa009200.86612946
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84409423
68Alzheimers disease_Homo sapiens_hsa050100.82697182
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81902842
70Glutathione metabolism_Homo sapiens_hsa004800.81668733
71Endometrial cancer_Homo sapiens_hsa052130.81281571
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77972801
73Bladder cancer_Homo sapiens_hsa052190.77669486
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76385890
75Folate biosynthesis_Homo sapiens_hsa007900.75217308
76Proteoglycans in cancer_Homo sapiens_hsa052050.74456776
77Ribosome_Homo sapiens_hsa030100.72780407
78Tight junction_Homo sapiens_hsa045300.71525758
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69714279
80Pentose phosphate pathway_Homo sapiens_hsa000300.69006936
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66033225
82Pancreatic cancer_Homo sapiens_hsa052120.65190243
83Notch signaling pathway_Homo sapiens_hsa043300.64837598
84Non-small cell lung cancer_Homo sapiens_hsa052230.62865064
85Fatty acid metabolism_Homo sapiens_hsa012120.62336644
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61877750
87Alcoholism_Homo sapiens_hsa050340.60586545
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59801761
89Basal cell carcinoma_Homo sapiens_hsa052170.59538250
90Purine metabolism_Homo sapiens_hsa002300.59160121
91Herpes simplex infection_Homo sapiens_hsa051680.57184014
92Focal adhesion_Homo sapiens_hsa045100.56148020
93Glucagon signaling pathway_Homo sapiens_hsa049220.55784172
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55379622
95Metabolic pathways_Homo sapiens_hsa011000.54942790
96AMPK signaling pathway_Homo sapiens_hsa041520.54748415
97Caffeine metabolism_Homo sapiens_hsa002320.54601390
98Prostate cancer_Homo sapiens_hsa052150.54552862
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54448395
100N-Glycan biosynthesis_Homo sapiens_hsa005100.54231650
101Insulin signaling pathway_Homo sapiens_hsa049100.53897038
102Glioma_Homo sapiens_hsa052140.53525697
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.51993489
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50123343
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49732997
106FoxO signaling pathway_Homo sapiens_hsa040680.48865561
107Renal cell carcinoma_Homo sapiens_hsa052110.48525535
108HIF-1 signaling pathway_Homo sapiens_hsa040660.48270353
109Hepatitis B_Homo sapiens_hsa051610.47986623
110Pathways in cancer_Homo sapiens_hsa052000.46496320
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46430943
112Apoptosis_Homo sapiens_hsa042100.45304817
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.44095470
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43767238
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43649619
116Insulin resistance_Homo sapiens_hsa049310.43194556
117Fatty acid degradation_Homo sapiens_hsa000710.43085092
118Retinol metabolism_Homo sapiens_hsa008300.42871283
119Peroxisome_Homo sapiens_hsa041460.42448372
120Legionellosis_Homo sapiens_hsa051340.42125302
121Cardiac muscle contraction_Homo sapiens_hsa042600.41953550
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41852121
123Hedgehog signaling pathway_Homo sapiens_hsa043400.41555163
124Estrogen signaling pathway_Homo sapiens_hsa049150.39867170
125Vitamin B6 metabolism_Homo sapiens_hsa007500.39736661
126Pyruvate metabolism_Homo sapiens_hsa006200.39517049
127beta-Alanine metabolism_Homo sapiens_hsa004100.38843155
128Melanoma_Homo sapiens_hsa052180.34962832
129Wnt signaling pathway_Homo sapiens_hsa043100.34439680
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.33630927
131Nitrogen metabolism_Homo sapiens_hsa009100.33055906
132VEGF signaling pathway_Homo sapiens_hsa043700.32372271
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32233438
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32125971
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31959718
136ECM-receptor interaction_Homo sapiens_hsa045120.31531635
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31238398
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30131889
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29915372
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.29237075
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.28319426
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.25549218
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.24494287
144Long-term depression_Homo sapiens_hsa047300.24248098
145Tryptophan metabolism_Homo sapiens_hsa003800.23913709
146Starch and sucrose metabolism_Homo sapiens_hsa005000.21832833
147Gap junction_Homo sapiens_hsa045400.21302902
148Fatty acid biosynthesis_Homo sapiens_hsa000610.18825617
149Chemical carcinogenesis_Homo sapiens_hsa052040.18732884

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »