DHX30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.50361880
2regulation of translational fidelity (GO:0006450)4.50521212
3piRNA metabolic process (GO:0034587)4.47557955
4mitotic chromosome condensation (GO:0007076)4.37240959
5DNA strand elongation involved in DNA replication (GO:0006271)4.31430386
6synaptonemal complex assembly (GO:0007130)4.28500197
7cilium or flagellum-dependent cell motility (GO:0001539)4.23748416
8synaptonemal complex organization (GO:0070193)4.20201282
9DNA strand elongation (GO:0022616)4.19244568
10DNA replication initiation (GO:0006270)4.16696071
11sperm-egg recognition (GO:0035036)3.96742883
12male meiosis (GO:0007140)3.89450451
13proline biosynthetic process (GO:0006561)3.87451537
14binding of sperm to zona pellucida (GO:0007339)3.86252156
15nuclear pore complex assembly (GO:0051292)3.84445619
16nuclear pore organization (GO:0006999)3.83678836
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.80146389
18sperm motility (GO:0030317)3.73742453
19rRNA transcription (GO:0009303)3.73337840
20spermatid development (GO:0007286)3.72319093
21telomere maintenance via semi-conservative replication (GO:0032201)3.60228294
22heterochromatin organization (GO:0070828)3.55871171
23chromosome organization involved in meiosis (GO:0070192)3.54462482
24regulation of histone H3-K9 methylation (GO:0051570)3.52514382
25cell-cell recognition (GO:0009988)3.52066125
26motile cilium assembly (GO:0044458)3.47144965
27formation of translation preinitiation complex (GO:0001731)3.40860367
28pre-miRNA processing (GO:0031054)3.40528427
29axonemal dynein complex assembly (GO:0070286)3.39163257
30fusion of sperm to egg plasma membrane (GO:0007342)3.39063280
31microtubule depolymerization (GO:0007019)3.38177023
32COPI coating of Golgi vesicle (GO:0048205)3.37329102
33Golgi transport vesicle coating (GO:0048200)3.37329102
34ribosomal small subunit biogenesis (GO:0042274)3.36777389
35acrosome reaction (GO:0007340)3.34768537
36histone H2A acetylation (GO:0043968)3.34151416
37chromatin assembly (GO:0031497)3.33270738
38DNA methylation involved in gamete generation (GO:0043046)3.31953991
39protein complex localization (GO:0031503)3.31572363
40regulation of cilium movement (GO:0003352)3.30674489
41acrosome assembly (GO:0001675)3.29264051
42nucleosome disassembly (GO:0006337)3.28558017
43protein-DNA complex disassembly (GO:0032986)3.28558017
44negative regulation of mRNA processing (GO:0050686)3.25405546
45DNA topological change (GO:0006265)3.21599785
46regulation of centriole replication (GO:0046599)3.21593693
47DNA synthesis involved in DNA repair (GO:0000731)3.20951670
48maturation of SSU-rRNA (GO:0030490)3.19688933
49negative regulation of histone methylation (GO:0031061)3.17133474
50male meiosis I (GO:0007141)3.17023299
51nuclear envelope reassembly (GO:0031468)3.16824106
52mitotic nuclear envelope reassembly (GO:0007084)3.16824106
53snRNA metabolic process (GO:0016073)3.15348300
54peptidyl-arginine omega-N-methylation (GO:0035247)3.10406264
55DNA replication checkpoint (GO:0000076)3.08916342
56negative regulation of cell size (GO:0045792)3.08180436
57DNA replication-dependent nucleosome organization (GO:0034723)3.06754149
58DNA replication-dependent nucleosome assembly (GO:0006335)3.06754149
59establishment of integrated proviral latency (GO:0075713)3.05545462
60mitochondrial DNA metabolic process (GO:0032042)3.05080648
61synapsis (GO:0007129)3.04251378
62cellular protein complex localization (GO:0034629)3.01977182
63histone H4-K5 acetylation (GO:0043981)3.00682126
64histone H4-K8 acetylation (GO:0043982)3.00682126
65meiotic nuclear division (GO:0007126)2.99781885
66dosage compensation (GO:0007549)2.99023663
67regulation of chromatin binding (GO:0035561)2.98691055
68translesion synthesis (GO:0019985)2.98394639
69gene silencing by RNA (GO:0031047)2.93844023
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93616914
71peptidyl-arginine N-methylation (GO:0035246)2.93192609
72peptidyl-arginine methylation (GO:0018216)2.93192609
73DNA conformation change (GO:0071103)2.92869303
74negative regulation of mRNA metabolic process (GO:1903312)2.92815399
75IMP biosynthetic process (GO:0006188)2.90598392
76peptidyl-lysine dimethylation (GO:0018027)2.90279495
77negative regulation of organelle assembly (GO:1902116)2.89523526
78negative regulation of RNA splicing (GO:0033119)2.89467512
79ribosome biogenesis (GO:0042254)2.88731214
80nuclear envelope organization (GO:0006998)2.88120669
81snRNA processing (GO:0016180)2.86984009
82pore complex assembly (GO:0046931)2.86066639
83plasma membrane fusion (GO:0045026)2.81545232
84ribonucleoprotein complex biogenesis (GO:0022613)2.79170418
85histone H3-K9 methylation (GO:0051567)2.78581241
86histone arginine methylation (GO:0034969)2.78043975
87regulation of mitochondrial translation (GO:0070129)2.77813848
88telomere maintenance via recombination (GO:0000722)2.77791185
89monoubiquitinated protein deubiquitination (GO:0035520)2.77269571
90negative regulation of DNA-templated transcription, elongation (GO:0032785)2.76708088
91positive regulation of cell cycle checkpoint (GO:1901978)2.76314829
92intra-S DNA damage checkpoint (GO:0031573)2.75297326
93regulation of meiosis I (GO:0060631)2.74638180
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74404246
95histone H4-K12 acetylation (GO:0043983)2.74141904
96protein maturation by protein folding (GO:0022417)2.73644562
97multicellular organism reproduction (GO:0032504)2.71132923
98cell wall macromolecule catabolic process (GO:0016998)2.70103709
99cell wall macromolecule metabolic process (GO:0044036)2.70103709
100regulation of RNA export from nucleus (GO:0046831)2.69485691
101meiosis I (GO:0007127)2.69382387
102mitochondrial fusion (GO:0008053)2.67504605
103positive regulation of DNA-dependent DNA replication (GO:2000105)2.66316164
104L-serine metabolic process (GO:0006563)2.66026949
105DNA methylation (GO:0006306)2.65010552
106DNA alkylation (GO:0006305)2.65010552
107mitotic nuclear envelope disassembly (GO:0007077)2.63966714
108mitochondrion transport along microtubule (GO:0047497)2.63205672
109establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63205672
110base-excision repair (GO:0006284)2.62669262
111gene silencing (GO:0016458)2.61797625
112DNA packaging (GO:0006323)2.61780374
113epithelial cilium movement (GO:0003351)2.61333671
114germ cell development (GO:0007281)2.59717018
115tRNA methylation (GO:0030488)2.59404917
116postreplication repair (GO:0006301)2.59185400
117mitotic metaphase plate congression (GO:0007080)2.58537274
118folic acid metabolic process (GO:0046655)2.58059195
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57736411
120reciprocal DNA recombination (GO:0035825)2.57443149
121reciprocal meiotic recombination (GO:0007131)2.57443149
122establishment of mitochondrion localization (GO:0051654)2.57208958
123meiotic cell cycle process (GO:1903046)2.56836171
124nucleus organization (GO:0006997)2.56764094
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56514559
126mitotic sister chromatid cohesion (GO:0007064)2.54958683
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54258860
128positive regulation of synapse maturation (GO:0090129)2.53586553
129regulation of DNA damage checkpoint (GO:2000001)2.53389385
130mitotic sister chromatid segregation (GO:0000070)2.53061554
131nuclear envelope disassembly (GO:0051081)2.52892465
132membrane disassembly (GO:0030397)2.52892465
133protein export from nucleus (GO:0006611)2.52852431
134positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.52429363
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.52355722
136regulation of gene silencing by RNA (GO:0060966)2.52038570
137regulation of posttranscriptional gene silencing (GO:0060147)2.52038570
138regulation of gene silencing by miRNA (GO:0060964)2.52038570
139sister chromatid segregation (GO:0000819)2.51980698
140chromatin assembly or disassembly (GO:0006333)2.51935647
141mitotic recombination (GO:0006312)2.51702303
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.50178671
143ncRNA 3-end processing (GO:0043628)2.49825401
144chromosome condensation (GO:0030261)2.49573324
145RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49107683
146mRNA splicing, via spliceosome (GO:0000398)2.49107683
147regulation of centrosome cycle (GO:0046605)2.46776794
148ATP-dependent chromatin remodeling (GO:0043044)2.46494222
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.46463077
150intracellular estrogen receptor signaling pathway (GO:0030520)2.45865266
151protein localization to kinetochore (GO:0034501)2.45567186
152spermatogenesis (GO:0007283)2.45520562
153apoptotic process involved in morphogenesis (GO:0060561)2.45357421
154male gamete generation (GO:0048232)2.45339778
155regulation of translational elongation (GO:0006448)2.45260283
156mitochondrial RNA metabolic process (GO:0000959)2.44804016
157proline metabolic process (GO:0006560)2.44793962
158DNA methylation or demethylation (GO:0044728)2.44622083
159histone H4-K16 acetylation (GO:0043984)2.43974929
160protein localization to chromosome, centromeric region (GO:0071459)2.43673728
161RNA localization (GO:0006403)2.42774217
162positive regulation of RNA splicing (GO:0033120)2.42075495
163DNA duplex unwinding (GO:0032508)2.40932786
164positive regulation of histone methylation (GO:0031062)2.40914802
165DNA geometric change (GO:0032392)2.40595264
166mRNA splice site selection (GO:0006376)2.40520823
167cilium movement (GO:0003341)2.40434557
168histone exchange (GO:0043486)2.39367766
169regulation of NFAT protein import into nucleus (GO:0051532)2.39082212
170mRNA transport (GO:0051028)2.38202204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54075834
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.94398922
3EZH2_22144423_ChIP-Seq_EOC_Human4.17859181
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.68972570
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78514447
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55902834
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44093223
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34959555
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24082268
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.22192880
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13399645
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09782211
13CIITA_25753668_ChIP-Seq_RAJI_Human1.99885401
14VDR_21846776_ChIP-Seq_THP-1_Human1.99724409
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.99450119
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99408527
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96403754
18* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88821286
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85529075
20ZNF263_19887448_ChIP-Seq_K562_Human1.83995370
21DCP1A_22483619_ChIP-Seq_HELA_Human1.83428908
22LXR_22292898_ChIP-Seq_THP-1_Human1.80870795
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73391025
24* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73122121
25MYC_22102868_ChIP-Seq_BL_Human1.71864606
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68894691
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68432523
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67245928
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66230813
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63003625
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60195795
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60075647
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58867172
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57644123
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.55545668
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.53596209
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52249597
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50741836
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.49352685
40* P68_20966046_ChIP-Seq_HELA_Human1.47953156
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.46543402
42XRN2_22483619_ChIP-Seq_HELA_Human1.45951047
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45398205
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44067635
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43517003
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42373425
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.39358388
48RACK7_27058665_Chip-Seq_MCF-7_Human1.35053056
49REST_21632747_ChIP-Seq_MESCs_Mouse1.34283131
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32744853
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31031099
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.30807372
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30504362
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30377787
55* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30119440
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28724797
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28323814
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28318011
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28260237
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26281612
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25912234
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.25562279
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25082560
64* ETS1_20019798_ChIP-Seq_JURKAT_Human1.24241349
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.23768946
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23259725
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22685290
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21794578
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19866504
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.19588310
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.19210412
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18363280
73KDM2B_26808549_Chip-Seq_DND41_Human1.18269409
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18076828
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16559443
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15735687
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15320608
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.14576308
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13585117
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13473404
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13298515
82FOXP3_21729870_ChIP-Seq_TREG_Human1.12196832
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12098740
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10496484
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10202570
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10191928
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.09973274
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09112711
89TTF2_22483619_ChIP-Seq_HELA_Human1.06003537
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05778112
91* GABP_19822575_ChIP-Seq_HepG2_Human1.05196145
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04374860
93KDM2B_26808549_Chip-Seq_K562_Human1.04358398
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04281955
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03874581
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03580190
97TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02843196
98* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02443888
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02361533
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02277942
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02226465
102CREB1_26743006_Chip-Seq_LNCaP_Human1.02216183
103* TCF7_22412390_ChIP-Seq_EML_Mouse1.02134065
104* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01344967
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01027601
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00994168
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00365309
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.00247040
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99728822
110* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99658517
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98165690
112VDR_23849224_ChIP-Seq_CD4+_Human0.98148402
113ZNF274_21170338_ChIP-Seq_K562_Hela0.94536443
114REST_18959480_ChIP-ChIP_MESCs_Mouse0.93335403
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92042810
116* KDM5A_27292631_Chip-Seq_BREAST_Human0.91062579
117* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90694739
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90027154
119* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89668958
120SOX9_26525672_Chip-Seq_HEART_Mouse0.89194886
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88061018
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87884390
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.86653500
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86399869
125* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82115948
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80369053
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80026242
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78355035
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76389205
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.76272447
131* PHF8_20622854_ChIP-Seq_HELA_Human0.76249097
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75842047
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74793034
134E2F1_17053090_ChIP-ChIP_MCF-7_Human0.74708171
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.74624889
136DROSHA_22980978_ChIP-Seq_HELA_Human0.73985632
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.72609522
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71662091
139PADI4_21655091_ChIP-ChIP_MCF-7_Human0.71124389
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70901118
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.69910223
142SMC4_20622854_ChIP-Seq_HELA_Human0.69504667
143FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68626716
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68080973
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.67855724
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.67689889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.21913207
2MP0008877_abnormal_DNA_methylation3.62078373
3MP0003111_abnormal_nucleus_morphology2.81639251
4MP0010094_abnormal_chromosome_stability2.76585593
5MP0002653_abnormal_ependyma_morphology2.76242045
6MP0008057_abnormal_DNA_replication2.47584426
7MP0003787_abnormal_imprinting2.44047737
8MP0003123_paternal_imprinting2.43940304
9MP0004859_abnormal_synaptic_plasticity2.42946275
10MP0003698_abnormal_male_reproductive2.41574845
11MP0008058_abnormal_DNA_repair2.29652518
12MP0001929_abnormal_gametogenesis2.28796782
13MP0003121_genomic_imprinting2.22285167
14MP0003077_abnormal_cell_cycle2.21630310
15MP0003705_abnormal_hypodermis_morpholog2.08216686
16MP0000569_abnormal_digit_pigmentation2.01851571
17MP0002210_abnormal_sex_determination2.01227300
18MP0003693_abnormal_embryo_hatching1.99971741
19MP0002249_abnormal_larynx_morphology1.98868246
20MP0004858_abnormal_nervous_system1.93788778
21MP0001346_abnormal_lacrimal_gland1.82743982
22MP0002822_catalepsy1.82023318
23MP0005623_abnormal_meninges_morphology1.77118005
24MP0000003_abnormal_adipose_tissue1.73256682
25MP0001986_abnormal_taste_sensitivity1.65150797
26MP0008007_abnormal_cellular_replicative1.62339773
27MP0001145_abnormal_male_reproductive1.62285934
28MP0004185_abnormal_adipocyte_glucose1.62180830
29MP0003385_abnormal_body_wall1.55371960
30MP0004957_abnormal_blastocyst_morpholog1.55070954
31MP0002160_abnormal_reproductive_system1.53514373
32MP0001661_extended_life_span1.52054597
33MP0003122_maternal_imprinting1.51483881
34MP0003880_abnormal_central_pattern1.49071637
35MP0003635_abnormal_synaptic_transmissio1.48491916
36MP0004233_abnormal_muscle_weight1.47107306
37MP0006292_abnormal_olfactory_placode1.42162239
38MP0005451_abnormal_body_composition1.40162862
39MP0002161_abnormal_fertility/fecundity1.38894866
40MP0000653_abnormal_sex_gland1.38648637
41MP0005423_abnormal_somatic_nervous1.37133398
42MP0001730_embryonic_growth_arrest1.36925481
43MP0001849_ear_inflammation1.32685923
44MP0000751_myopathy1.30377425
45MP0003119_abnormal_digestive_system1.27985893
46MP0000733_abnormal_muscle_development1.27509868
47MP0003861_abnormal_nervous_system1.27197102
48MP0004133_heterotaxia1.26582226
49MP0003136_yellow_coat_color1.26567971
50MP0002084_abnormal_developmental_patter1.25336204
51MP0003786_premature_aging1.23420874
52MP0003283_abnormal_digestive_organ1.22971709
53MP0002063_abnormal_learning/memory/cond1.21566003
54MP0008961_abnormal_basal_metabolism1.20405026
55MP0002697_abnormal_eye_size1.18337083
56MP0008932_abnormal_embryonic_tissue1.17164083
57MP0002085_abnormal_embryonic_tissue1.16912396
58MP0008995_early_reproductive_senescence1.15478251
59MP0001348_abnormal_lacrimal_gland1.14760958
60MP0006035_abnormal_mitochondrial_morpho1.14197391
61MP0000049_abnormal_middle_ear1.13736123
62MP0000350_abnormal_cell_proliferation1.11547607
63MP0004811_abnormal_neuron_physiology1.11153653
64MP0000537_abnormal_urethra_morphology1.09029209
65MP0008260_abnormal_autophagy1.09006457
66MP0005394_taste/olfaction_phenotype1.07984429
67MP0005499_abnormal_olfactory_system1.07984429
68MP0005171_absent_coat_pigmentation1.06243738
69MP0003890_abnormal_embryonic-extraembry1.03866117
70MP0009278_abnormal_bone_marrow1.03545516
71MP0001293_anophthalmia1.03508214
72MP0003942_abnormal_urinary_system1.03432749
73MP0002184_abnormal_innervation1.03014783
74MP0001697_abnormal_embryo_size1.02351205
75MP0000358_abnormal_cell_content/1.01511118
76MP0000778_abnormal_nervous_system1.01441485
77MP0002152_abnormal_brain_morphology1.00766305
78MP0002877_abnormal_melanocyte_morpholog0.99753926
79MP0002092_abnormal_eye_morphology0.99652183
80MP0005501_abnormal_skin_physiology0.99603294
81MP0005174_abnormal_tail_pigmentation0.99444047
82MP0002572_abnormal_emotion/affect_behav0.99117914
83MP0001672_abnormal_embryogenesis/_devel0.98307659
84MP0005380_embryogenesis_phenotype0.98307659
85MP0010030_abnormal_orbit_morphology0.98226825
86MP0001299_abnormal_eye_distance/0.98187138
87MP0000631_abnormal_neuroendocrine_gland0.97242910
88MP0009046_muscle_twitch0.96873088
89MP0000759_abnormal_skeletal_muscle0.96152694
90MP0006072_abnormal_retinal_apoptosis0.96115754
91MP0010352_gastrointestinal_tract_polyps0.95684412
92MP0009745_abnormal_behavioral_response0.94692822
93MP0003315_abnormal_perineum_morphology0.94311940
94MP0000955_abnormal_spinal_cord0.94011744
95MP0000747_muscle_weakness0.93119793
96MP0005076_abnormal_cell_differentiation0.92674519
97MP0002080_prenatal_lethality0.92450051
98MP0004197_abnormal_fetal_growth/weight/0.91924667
99MP0002111_abnormal_tail_morphology0.91700826
100MP0009053_abnormal_anal_canal0.91389577
101MP0000678_abnormal_parathyroid_gland0.91010346
102MP0000013_abnormal_adipose_tissue0.90947831
103MP0004808_abnormal_hematopoietic_stem0.90852863
104MP0003937_abnormal_limbs/digits/tail_de0.89371248
105MP0002751_abnormal_autonomic_nervous0.88500362
106MP0002557_abnormal_social/conspecific_i0.88193835
107MP0001270_distended_abdomen0.87700883
108MP0002009_preneoplasia0.87134966
109MP0000750_abnormal_muscle_regeneration0.86316003
110MP0002234_abnormal_pharynx_morphology0.85404928
111MP0005375_adipose_tissue_phenotype0.84344785
112MP0003984_embryonic_growth_retardation0.84198572
113MP0001984_abnormal_olfaction0.83694549
114MP0002638_abnormal_pupillary_reflex0.83432537
115MP0005621_abnormal_cell_physiology0.83067800
116MP0002116_abnormal_craniofacial_bone0.82994865
117MP0002114_abnormal_axial_skeleton0.82505212
118MP0005058_abnormal_lysosome_morphology0.82145566
119MP0001968_abnormal_touch/_nociception0.82112116
120MP0002269_muscular_atrophy0.82110924
121MP0008789_abnormal_olfactory_epithelium0.81762871
122MP0002088_abnormal_embryonic_growth/wei0.81157348
123MP0002163_abnormal_gland_morphology0.81092230
124MP0001529_abnormal_vocalization0.80986933
125MP0005384_cellular_phenotype0.80724577
126MP0002089_abnormal_postnatal_growth/wei0.79386517
127MP0004270_analgesia0.79103082
128MP0005253_abnormal_eye_physiology0.78733671
129MP0002882_abnormal_neuron_morphology0.78458469
130MP0003115_abnormal_respiratory_system0.78444262
131MP0001486_abnormal_startle_reflex0.78342073
132MP0009672_abnormal_birth_weight0.78199471
133MP0000313_abnormal_cell_death0.77939103
134MP0000566_synostosis0.77833842
135MP0000534_abnormal_ureter_morphology0.77279469
136MP0003935_abnormal_craniofacial_develop0.76626926
137MP0000428_abnormal_craniofacial_morphol0.76379542
138MP0010234_abnormal_vibrissa_follicle0.76274954
139MP0002075_abnormal_coat/hair_pigmentati0.76221136
140MP0002735_abnormal_chemical_nociception0.74097815
141MP0009703_decreased_birth_body0.73871409
142MP0002102_abnormal_ear_morphology0.73753282
143MP0002272_abnormal_nervous_system0.72427651
144MP0010307_abnormal_tumor_latency0.71917579
145MP0005389_reproductive_system_phenotype0.71570813
146MP0005645_abnormal_hypothalamus_physiol0.71106510
147MP0002938_white_spotting0.70546706
148MP0002064_seizures0.70139155
149MP0002086_abnormal_extraembryonic_tissu0.69675668
150MP0000703_abnormal_thymus_morphology0.69361438

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.22745834
2Absent/shortened dynein arms (HP:0200106)4.13221386
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.13221386
4Abnormality of the lower motor neuron (HP:0002366)4.07701688
5Microvesicular hepatic steatosis (HP:0001414)3.59470503
6Ulnar bowing (HP:0003031)3.07223637
7Chronic bronchitis (HP:0004469)3.05582817
8High anterior hairline (HP:0009890)2.89061419
9Progressive muscle weakness (HP:0003323)2.84927557
10Ependymoma (HP:0002888)2.77585769
11Ragged-red muscle fibers (HP:0003200)2.76890657
12Abnormal respiratory motile cilium physiology (HP:0012261)2.74796935
13Degeneration of anterior horn cells (HP:0002398)2.63499517
14Abnormality of the anterior horn cell (HP:0006802)2.63499517
15Hyperacusis (HP:0010780)2.60171393
16Facial cleft (HP:0002006)2.59144419
17Abnormal respiratory epithelium morphology (HP:0012253)2.57103659
18Abnormal respiratory motile cilium morphology (HP:0005938)2.57103659
19Amyotrophic lateral sclerosis (HP:0007354)2.56725104
20Truncus arteriosus (HP:0001660)2.53124041
21Infertility (HP:0000789)2.53020099
22Selective tooth agenesis (HP:0001592)2.45480659
2311 pairs of ribs (HP:0000878)2.44560517
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43707561
25Nephronophthisis (HP:0000090)2.43642196
26Proximal placement of thumb (HP:0009623)2.38867603
27Medulloblastoma (HP:0002885)2.36177618
28Astrocytoma (HP:0009592)2.30675006
29Abnormality of the astrocytes (HP:0100707)2.30675006
30Deviation of the thumb (HP:0009603)2.28963798
31Progressive external ophthalmoplegia (HP:0000590)2.28678566
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28090035
33Short 4th metacarpal (HP:0010044)2.28090035
34Long palpebral fissure (HP:0000637)2.27839867
35Rhinitis (HP:0012384)2.24783420
36Abnormality of ocular smooth pursuit (HP:0000617)2.21532212
37Nasal polyposis (HP:0100582)2.20755447
38Chromsome breakage (HP:0040012)2.19437498
39Pointed chin (HP:0000307)2.19071741
40Dysmetric saccades (HP:0000641)2.18102137
41Impulsivity (HP:0100710)2.17046110
42Abnormality of DNA repair (HP:0003254)2.16893779
43Testicular atrophy (HP:0000029)2.16883950
44Poikiloderma (HP:0001029)2.16867155
45Renal duplication (HP:0000075)2.13332455
46Atrophy/Degeneration involving motor neurons (HP:0007373)2.12718157
47Glioma (HP:0009733)2.12161930
48Abnormality of cochlea (HP:0000375)2.12119458
49Cholecystitis (HP:0001082)2.08837055
50Abnormal gallbladder physiology (HP:0012438)2.08837055
51Entropion (HP:0000621)2.05882843
52Turricephaly (HP:0000262)2.05676317
53Increased nuchal translucency (HP:0010880)2.05465962
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04566006
55Neoplasm of the oral cavity (HP:0100649)2.04366859
56Difficulty climbing stairs (HP:0003551)2.04239705
57Disproportionate tall stature (HP:0001519)2.02661377
58Premature skin wrinkling (HP:0100678)2.02558700
59Bronchitis (HP:0012387)2.02273129
60Ectopic kidney (HP:0000086)2.01537317
61Abnormality of the carotid arteries (HP:0005344)2.00577742
62Upper limb amyotrophy (HP:0009129)1.99562401
63Distal upper limb amyotrophy (HP:0007149)1.99562401
64Supernumerary spleens (HP:0009799)1.99024677
65Aplasia/Hypoplasia of the uvula (HP:0010293)1.98899406
66Reticulocytopenia (HP:0001896)1.98311573
67Achilles tendon contracture (HP:0001771)1.98244460
68Renovascular hypertension (HP:0100817)1.97796310
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97780703
70Absent epiphyses (HP:0010577)1.97780703
71Peripheral hypomyelination (HP:0007182)1.97663098
72Elfin facies (HP:0004428)1.94887458
73Abnormality of the labia minora (HP:0012880)1.94054442
74Abnormal ciliary motility (HP:0012262)1.93928823
75Impaired vibration sensation in the lower limbs (HP:0002166)1.93230162
76Deep palmar crease (HP:0006191)1.93116069
77Distal lower limb amyotrophy (HP:0008944)1.92241940
78Trismus (HP:0000211)1.90893548
79Broad face (HP:0000283)1.90567327
80Ankle clonus (HP:0011448)1.89687632
81Abnormality of the calcaneus (HP:0008364)1.89660668
82Abnormality of the aortic arch (HP:0012303)1.89051346
83Self-mutilation (HP:0000742)1.88418145
84Patellar dislocation (HP:0002999)1.87466961
85Shoulder girdle muscle weakness (HP:0003547)1.87083536
86Broad palm (HP:0001169)1.86270556
87Duplication of thumb phalanx (HP:0009942)1.85427226
88Neoplasm of the heart (HP:0100544)1.85098101
89Impaired smooth pursuit (HP:0007772)1.85060279
90Atelectasis (HP:0100750)1.84726892
91Missing ribs (HP:0000921)1.84223853
92Glossoptosis (HP:0000162)1.83649556
93Meckel diverticulum (HP:0002245)1.83073162
94Morphological abnormality of the inner ear (HP:0011390)1.82476242
95Birth length less than 3rd percentile (HP:0003561)1.81592544
96Squamous cell carcinoma (HP:0002860)1.81392840
97Microretrognathia (HP:0000308)1.81205081
98Abnormality of the distal phalanges of the toes (HP:0010182)1.81095641
99Heterotopia (HP:0002282)1.80256130
100Abnormality of glycolysis (HP:0004366)1.80249142
101Overriding aorta (HP:0002623)1.79484525
102Patellar aplasia (HP:0006443)1.79395587
103Hand muscle atrophy (HP:0009130)1.79260163
104Insomnia (HP:0100785)1.79114425
105Abnormality of reticulocytes (HP:0004312)1.78558206
106Hyperthyroidism (HP:0000836)1.78262095
107Premature ovarian failure (HP:0008209)1.78223346
108Bowel incontinence (HP:0002607)1.78056411
109Bronchiectasis (HP:0002110)1.77612112
110Abnormality of the ileum (HP:0001549)1.76338565
111Abnormality of the phalanges of the hallux (HP:0010057)1.76174808
112Thin ribs (HP:0000883)1.75724165
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.75063744
114Abnormal large intestine physiology (HP:0012700)1.74657446
115Medial flaring of the eyebrow (HP:0010747)1.74632829
116Shallow orbits (HP:0000586)1.73634581
117Urethral obstruction (HP:0000796)1.72809268
118Duplicated collecting system (HP:0000081)1.72253958
119Abnormality of the renal collecting system (HP:0004742)1.71736831
120Spina bifida occulta (HP:0003298)1.70603386
121Abnormality of the fingertips (HP:0001211)1.70291112
122Reticulocytosis (HP:0001923)1.69201347
123Septate vagina (HP:0001153)1.68909633
124Spinal muscular atrophy (HP:0007269)1.68141120
125Obsessive-compulsive behavior (HP:0000722)1.68140271
126Myopathic facies (HP:0002058)1.67937273
127Aplasia/Hypoplasia of the patella (HP:0006498)1.67238675
128Cerebral hypomyelination (HP:0006808)1.66691249
129Retinal dysplasia (HP:0007973)1.66070055
130Abnormality of the renal medulla (HP:0100957)1.65621289
131Abnormal ventriculo-arterial connection (HP:0011563)1.65515747
132Transposition of the great arteries (HP:0001669)1.65515747
133Abnormal connection of the cardiac segments (HP:0011545)1.65515747
134Spastic diplegia (HP:0001264)1.64984642
135Athetosis (HP:0002305)1.64121771
136Optic nerve coloboma (HP:0000588)1.64107673
137Neoplasm of the adrenal cortex (HP:0100641)1.64010522
138Stridor (HP:0010307)1.63763158
139Breast hypoplasia (HP:0003187)1.63024787
140Preauricular skin tag (HP:0000384)1.62882182
141Abnormality of cells of the erythroid lineage (HP:0012130)1.62874857
142Sloping forehead (HP:0000340)1.62866348
143Abnormality of chromosome stability (HP:0003220)1.62136801
144Small intestinal stenosis (HP:0012848)1.61904444
145Duodenal stenosis (HP:0100867)1.61904444
146Trigonocephaly (HP:0000243)1.61807683
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.61401475
148Vertebral arch anomaly (HP:0008438)1.60861411
149Atresia of the external auditory canal (HP:0000413)1.60659656
150Absent thumb (HP:0009777)1.60646408
151Neoplasm of striated muscle (HP:0009728)1.60048720
152Overlapping toe (HP:0001845)1.59852754
153Molar tooth sign on MRI (HP:0002419)1.59107619
154Abnormality of midbrain morphology (HP:0002418)1.59107619
155Precocious puberty (HP:0000826)1.58910235
156Abnormal number of incisors (HP:0011064)1.58895501
157Postaxial foot polydactyly (HP:0001830)1.58186418
158Median cleft lip (HP:0000161)1.58016362
159Cortical dysplasia (HP:0002539)1.57662955
160Short ribs (HP:0000773)1.57046977
161Flat cornea (HP:0007720)1.56365422
162Truncal obesity (HP:0001956)1.55212251
163Abnormal lung lobation (HP:0002101)1.55049668
164Visual hallucinations (HP:0002367)1.54931021
165Hypopigmentation of the fundus (HP:0007894)1.54278043
166Fibular hypoplasia (HP:0003038)1.53686633
167Abnormality of the preputium (HP:0100587)1.53323120
168Prominent nose (HP:0000448)1.52885590
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.50914138
170Abnormality of the nasal mucosa (HP:0000433)1.50886416
171Basal cell carcinoma (HP:0002671)1.50267138
172Abnormality of the 4th metacarpal (HP:0010012)1.48981753
173Male infertility (HP:0003251)1.48586635
174Broad distal phalanx of finger (HP:0009836)1.48547260
175Lissencephaly (HP:0001339)1.48532368
176Gaze-evoked nystagmus (HP:0000640)1.47711020
177Megalocornea (HP:0000485)1.46112653
178Anal stenosis (HP:0002025)1.46024455
179Pelvic girdle muscle weakness (HP:0003749)1.44669800
180Colon cancer (HP:0003003)1.43915433
181Volvulus (HP:0002580)1.43663510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.26224541
2TRIB33.97487765
3PRKD33.70190102
4PDK43.16556494
5PDK33.16556494
6CDC73.00227287
7CDK122.63274682
8BUB12.57850662
9PNCK2.56048430
10NEK22.54661738
11EEF2K2.53959690
12NME22.52108564
13PASK2.49625899
14TSSK62.26287813
15ICK2.13161689
16BRD42.00632878
17TESK11.98178046
18MARK11.92707130
19PRPF4B1.91598925
20IRAK31.87397728
21NTRK31.82248256
22CAMK1D1.75796804
23TTK1.71781669
24SRPK11.71170483
25ATR1.68064035
26CCNB11.67785901
27SIK21.66086119
28MAP3K41.57576606
29SCYL21.55352622
30PDK21.55088567
31WEE11.52419461
32SIK31.52183641
33VRK21.45267502
34PIM21.42918104
35SIK11.42122081
36RIPK11.41607301
37KSR11.27368281
38CHEK11.26457687
39MKNK11.26055100
40PLK11.25961037
41TLK11.22357421
42LMTK21.21454775
43TYRO31.19985066
44PLK31.18077458
45MAP3K101.17036984
46BRAF1.16835804
47NTRK21.14868076
48STK381.14387839
49ARAF1.14203807
50DAPK11.12934576
51ALK1.12540142
52DYRK31.10630809
53CDK81.04255740
54ZAK1.02975768
55EPHA21.02532470
56MAP2K71.02462167
57UHMK11.01842500
58TESK21.01315562
59MKNK21.00462271
60PLK40.98923770
61CHEK20.97769530
62ATM0.97077398
63WNK30.95306798
64EPHA40.94827384
65TTN0.93739927
66PKN20.90599722
67MAP3K80.90490890
68MAPK110.89094310
69PAK60.87793292
70FGFR10.87449269
71CDK20.86975104
72SGK20.86493631
73CSNK1G30.84079098
74KDR0.83245754
75AKT30.82353790
76CASK0.82342204
77MAP3K90.80842229
78CSNK1A1L0.80796814
79CDK10.78628366
80MTOR0.76317190
81MINK10.74704462
82BRSK10.74431554
83TNIK0.74247062
84MAP3K110.71425822
85BCKDK0.70803618
86EIF2AK30.70543287
87MAPK130.69358804
88CDK90.68482725
89PRKD20.66435816
90RAF10.65945565
91MST1R0.65940713
92NME10.65261330
93RPS6KB10.64167257
94NEK10.62443372
95PRKDC0.61925538
96KSR20.61328033
97SGK30.60802445
98CDK40.60169071
99CDK11A0.59955224
100FGFR40.59279777
101PINK10.56217305
102BMX0.55011418
103RPS6KB20.54669148
104GSK3B0.53862464
105CSNK1E0.53524595
106CLK10.53467028
107VRK10.53380995
108PRKCG0.53309677
109PTK20.52770068
110CDC42BPA0.51427477
111LIMK10.50358791
112PRKCI0.49986553
113NTRK10.49239785
114DYRK1B0.49218273
115CAMKK10.49168165
116PAK10.48966304
117CDK70.48441412
118AURKB0.48043683
119AURKA0.46967579
120EIF2AK10.46110558
121CSNK1G10.45378988
122PRKAA10.45328621
123SGK2230.45149098
124SGK4940.45149098
125IRAK20.44405038
126MAPK140.44030051
127CAMK1G0.43685207
128PAK40.43616039
129AKT20.42657537
130CDK60.41768208
131CDK140.41445937
132RPS6KA50.41413813
133RPS6KC10.40600140
134RPS6KL10.40600140
135ERBB30.40440099
136MAPK100.40179156
137PTK2B0.40142782
138TAOK20.39752373
139ERN10.39639454
140MARK20.39226336
141DYRK1A0.38972305
142CDK180.38255127
143ILK0.38180514
144MAPK80.36892613
145TNK20.36783098
146RPS6KA20.36615150
147DAPK20.36118536
148CSNK1D0.35584652
149NEK60.34436152
150CDK150.34133452

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.06392509
2Spliceosome_Homo sapiens_hsa030402.44182842
3RNA transport_Homo sapiens_hsa030132.38869795
4mRNA surveillance pathway_Homo sapiens_hsa030152.38051389
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34053129
6DNA replication_Homo sapiens_hsa030302.33256985
7Biosynthesis of amino acids_Homo sapiens_hsa012302.30435749
8Fanconi anemia pathway_Homo sapiens_hsa034602.13960917
9Mismatch repair_Homo sapiens_hsa034302.08989377
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05182874
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02024786
12Oocyte meiosis_Homo sapiens_hsa041141.89320518
13Base excision repair_Homo sapiens_hsa034101.83348659
14Cell cycle_Homo sapiens_hsa041101.80529343
15Lysine degradation_Homo sapiens_hsa003101.67102759
16Long-term potentiation_Homo sapiens_hsa047201.64208216
17Ribosome_Homo sapiens_hsa030101.60881346
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58554680
19Homologous recombination_Homo sapiens_hsa034401.55774820
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54783931
21Nicotine addiction_Homo sapiens_hsa050331.52988789
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52822738
23Basal transcription factors_Homo sapiens_hsa030221.48976447
24Nucleotide excision repair_Homo sapiens_hsa034201.47285287
25RNA degradation_Homo sapiens_hsa030181.42600357
26Pentose phosphate pathway_Homo sapiens_hsa000301.42320071
27Vitamin B6 metabolism_Homo sapiens_hsa007501.40973692
28Amphetamine addiction_Homo sapiens_hsa050311.40459305
29Synaptic vesicle cycle_Homo sapiens_hsa047211.29944550
30Fructose and mannose metabolism_Homo sapiens_hsa000511.29911967
31Circadian entrainment_Homo sapiens_hsa047131.28953496
32Alcoholism_Homo sapiens_hsa050341.27233853
33Carbon metabolism_Homo sapiens_hsa012001.25193045
34Olfactory transduction_Homo sapiens_hsa047401.21326421
35Non-homologous end-joining_Homo sapiens_hsa034501.16110314
36Insulin secretion_Homo sapiens_hsa049111.16052362
37Dopaminergic synapse_Homo sapiens_hsa047281.14539192
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.13867473
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12899333
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.11693643
41RNA polymerase_Homo sapiens_hsa030201.10443248
42Glutamatergic synapse_Homo sapiens_hsa047241.10397104
43Glucagon signaling pathway_Homo sapiens_hsa049221.10098210
44Morphine addiction_Homo sapiens_hsa050321.09137234
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09029955
46Bladder cancer_Homo sapiens_hsa052191.08521272
47Taste transduction_Homo sapiens_hsa047421.07123143
48Basal cell carcinoma_Homo sapiens_hsa052171.06856272
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06207259
50One carbon pool by folate_Homo sapiens_hsa006701.05779261
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02881931
52Hedgehog signaling pathway_Homo sapiens_hsa043401.02507843
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01793689
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00947009
55Systemic lupus erythematosus_Homo sapiens_hsa053220.93722102
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92244766
57Wnt signaling pathway_Homo sapiens_hsa043100.91077275
58Pyrimidine metabolism_Homo sapiens_hsa002400.90657074
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89827193
60Estrogen signaling pathway_Homo sapiens_hsa049150.88486348
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86921960
62AMPK signaling pathway_Homo sapiens_hsa041520.86674219
63Purine metabolism_Homo sapiens_hsa002300.85310211
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83960637
65HTLV-I infection_Homo sapiens_hsa051660.83471678
66mTOR signaling pathway_Homo sapiens_hsa041500.82305303
67Calcium signaling pathway_Homo sapiens_hsa040200.82239160
68Vibrio cholerae infection_Homo sapiens_hsa051100.81975751
69Melanogenesis_Homo sapiens_hsa049160.81963896
70Viral carcinogenesis_Homo sapiens_hsa052030.81766729
71Renin secretion_Homo sapiens_hsa049240.80966421
72Dorso-ventral axis formation_Homo sapiens_hsa043200.79811029
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78913881
74Phototransduction_Homo sapiens_hsa047440.77870937
75Epstein-Barr virus infection_Homo sapiens_hsa051690.77852839
76Cholinergic synapse_Homo sapiens_hsa047250.76584010
77Pyruvate metabolism_Homo sapiens_hsa006200.75830072
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75788110
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75346048
80GABAergic synapse_Homo sapiens_hsa047270.75146845
81Other glycan degradation_Homo sapiens_hsa005110.74331752
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74184305
83Colorectal cancer_Homo sapiens_hsa052100.74063070
84Hippo signaling pathway_Homo sapiens_hsa043900.73530246
85Oxytocin signaling pathway_Homo sapiens_hsa049210.72935290
86Notch signaling pathway_Homo sapiens_hsa043300.72915619
87Pancreatic cancer_Homo sapiens_hsa052120.72654396
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72151186
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.71448246
90Gap junction_Homo sapiens_hsa045400.71160663
91Cocaine addiction_Homo sapiens_hsa050300.70890365
92p53 signaling pathway_Homo sapiens_hsa041150.69096030
93Inositol phosphate metabolism_Homo sapiens_hsa005620.68723989
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68233906
95Galactose metabolism_Homo sapiens_hsa000520.67824943
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67515345
97Endometrial cancer_Homo sapiens_hsa052130.66924112
98Acute myeloid leukemia_Homo sapiens_hsa052210.66746173
99VEGF signaling pathway_Homo sapiens_hsa043700.65238540
100Axon guidance_Homo sapiens_hsa043600.64249074
101Long-term depression_Homo sapiens_hsa047300.62976279
102Type II diabetes mellitus_Homo sapiens_hsa049300.62517950
103Gastric acid secretion_Homo sapiens_hsa049710.62309709
104Selenocompound metabolism_Homo sapiens_hsa004500.62093707
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61160554
106Glioma_Homo sapiens_hsa052140.61122039
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60865597
108Salivary secretion_Homo sapiens_hsa049700.59041707
109cAMP signaling pathway_Homo sapiens_hsa040240.58268641
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.57929407
111Prion diseases_Homo sapiens_hsa050200.57854332
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57831508
113Small cell lung cancer_Homo sapiens_hsa052220.57324758
114T cell receptor signaling pathway_Homo sapiens_hsa046600.55520676
115Non-small cell lung cancer_Homo sapiens_hsa052230.55375859
116GnRH signaling pathway_Homo sapiens_hsa049120.55137135
117Arginine biosynthesis_Homo sapiens_hsa002200.55129703
118Arginine and proline metabolism_Homo sapiens_hsa003300.54834978
119Antigen processing and presentation_Homo sapiens_hsa046120.53784603
120ErbB signaling pathway_Homo sapiens_hsa040120.51872111
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51737984
122Prostate cancer_Homo sapiens_hsa052150.51546521
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51439764
124MicroRNAs in cancer_Homo sapiens_hsa052060.50377225
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48977236
126MAPK signaling pathway_Homo sapiens_hsa040100.47630923
127N-Glycan biosynthesis_Homo sapiens_hsa005100.47626570
128Herpes simplex infection_Homo sapiens_hsa051680.46295268
129Serotonergic synapse_Homo sapiens_hsa047260.46127481
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.44191594
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43158424
132Chronic myeloid leukemia_Homo sapiens_hsa052200.42690633
133Primary immunodeficiency_Homo sapiens_hsa053400.42143259
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41561203
135Folate biosynthesis_Homo sapiens_hsa007900.40938552
136Huntingtons disease_Homo sapiens_hsa050160.40164713
137Thyroid cancer_Homo sapiens_hsa052160.40015957
138Insulin signaling pathway_Homo sapiens_hsa049100.39258358
139Apoptosis_Homo sapiens_hsa042100.36096616
140Steroid biosynthesis_Homo sapiens_hsa001000.35743222
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33054661
142Adherens junction_Homo sapiens_hsa045200.31211875

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