DHX32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.13487656
2COPI coating of Golgi vesicle (GO:0048205)6.13487656
3desmosome organization (GO:0002934)5.84730639
4intestinal epithelial cell development (GO:0060576)5.15716792
5COPII vesicle coating (GO:0048208)4.79906677
6hemidesmosome assembly (GO:0031581)4.79286764
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.53937354
8UDP-N-acetylglucosamine metabolic process (GO:0006047)4.49302492
9protein retention in ER lumen (GO:0006621)4.36856562
10cell adhesion mediated by integrin (GO:0033627)4.30575361
11folic acid-containing compound biosynthetic process (GO:0009396)3.94585956
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.79637601
13folic acid metabolic process (GO:0046655)3.72093749
14nucleotide-sugar biosynthetic process (GO:0009226)3.64092151
15nuclear pore complex assembly (GO:0051292)3.53696854
164-hydroxyproline metabolic process (GO:0019471)3.45797082
17proline biosynthetic process (GO:0006561)3.40224682
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.37450117
19skin morphogenesis (GO:0043589)3.35326235
20endocrine pancreas development (GO:0031018)3.33015591
21epithelial cell-cell adhesion (GO:0090136)3.32231277
22positive regulation of nuclease activity (GO:0032075)3.28289123
23columnar/cuboidal epithelial cell development (GO:0002066)3.28137234
24ventricular cardiac muscle cell development (GO:0055015)3.28130132
25gap junction assembly (GO:0016264)3.24552337
26purine nucleobase biosynthetic process (GO:0009113)3.12878807
27pteridine-containing compound biosynthetic process (GO:0042559)3.12242224
28tricarboxylic acid metabolic process (GO:0072350)3.12196612
29galactose catabolic process (GO:0019388)3.10986125
30regulation of transforming growth factor beta2 production (GO:0032909)3.09891967
31glandular epithelial cell differentiation (GO:0002067)3.07715760
32negative regulation of keratinocyte proliferation (GO:0010839)3.04684750
33NADH metabolic process (GO:0006734)3.02412392
34regulation of nuclease activity (GO:0032069)2.98146270
35tricarboxylic acid cycle (GO:0006099)2.96158045
36vesicle coating (GO:0006901)2.93458237
37endoplasmic reticulum unfolded protein response (GO:0030968)2.88842920
38sulfur amino acid catabolic process (GO:0000098)2.82690802
39nucleobase biosynthetic process (GO:0046112)2.82233687
40bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80598633
41cellular response to unfolded protein (GO:0034620)2.79483096
42regulation of cardioblast differentiation (GO:0051890)2.79472476
43interferon-gamma secretion (GO:0072643)2.76161261
44glycine metabolic process (GO:0006544)2.75703711
45protein maturation by protein folding (GO:0022417)2.75379353
46negative regulation of chondrocyte differentiation (GO:0032331)2.74339629
47formation of translation preinitiation complex (GO:0001731)2.73979446
48ribosome assembly (GO:0042255)2.73247534
49protein autoprocessing (GO:0016540)2.72461607
50nuclear pore organization (GO:0006999)2.71982620
51cellular response to topologically incorrect protein (GO:0035967)2.70971638
52fatty acid homeostasis (GO:0055089)2.70512477
53keratinocyte proliferation (GO:0043616)2.69871569
54regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69314793
55ER-nucleus signaling pathway (GO:0006984)2.69220589
56cysteine metabolic process (GO:0006534)2.68256843
57dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68123234
58intestinal absorption (GO:0050892)2.65603588
59nucleotide-sugar metabolic process (GO:0009225)2.64545301
60peptide hormone processing (GO:0016486)2.63646648
61regulation of water loss via skin (GO:0033561)2.63151225
62lysine metabolic process (GO:0006553)2.59675537
63lysine catabolic process (GO:0006554)2.59675537
64keratan sulfate catabolic process (GO:0042340)2.58378943
65L-phenylalanine metabolic process (GO:0006558)2.58185302
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58185302
67carnitine shuttle (GO:0006853)2.57591832
68regulation of cholesterol homeostasis (GO:2000188)2.54208561
69paraxial mesoderm development (GO:0048339)2.51342357
70biotin metabolic process (GO:0006768)2.49396837
71folic acid-containing compound metabolic process (GO:0006760)2.48887988
722-oxoglutarate metabolic process (GO:0006103)2.48215008
73nucleoside diphosphate biosynthetic process (GO:0009133)2.47280175
74mitotic metaphase plate congression (GO:0007080)2.47123573
75establishment of integrated proviral latency (GO:0075713)2.46827918
76nucleobase-containing small molecule interconversion (GO:0015949)2.46714862
77serine family amino acid catabolic process (GO:0009071)2.45898981
78type B pancreatic cell development (GO:0003323)2.45169070
79establishment of skin barrier (GO:0061436)2.44116662
80mitotic chromosome condensation (GO:0007076)2.43605376
81mesodermal cell differentiation (GO:0048333)2.43432470
82L-alpha-amino acid transmembrane transport (GO:1902475)2.42749903
83regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.41699405
84oxaloacetate metabolic process (GO:0006107)2.39543364
85cellular copper ion homeostasis (GO:0006878)2.39292947
86branching involved in mammary gland duct morphogenesis (GO:0060444)2.39129490
87valine metabolic process (GO:0006573)2.38982547
88fatty acid transmembrane transport (GO:1902001)2.38404425
89GDP-mannose metabolic process (GO:0019673)2.37602363
90acylglycerol homeostasis (GO:0055090)2.37370810
91triglyceride homeostasis (GO:0070328)2.37370810
92nucleotide salvage (GO:0043173)2.36851439
93response to unfolded protein (GO:0006986)2.36820155
94pore complex assembly (GO:0046931)2.36502654
95fatty acid beta-oxidation (GO:0006635)2.36494593
96regulation of mitochondrial translation (GO:0070129)2.35699510
97histone H2A monoubiquitination (GO:0035518)2.35676491
98tetrahydrofolate metabolic process (GO:0046653)2.35473397
99glandular epithelial cell development (GO:0002068)2.35226401
100branched-chain amino acid catabolic process (GO:0009083)2.34944859
101metaphase plate congression (GO:0051310)2.34115075
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33948426
103protein hydroxylation (GO:0018126)2.32950041
104response to topologically incorrect protein (GO:0035966)2.32881024
105membrane budding (GO:0006900)2.32288222
106peptidyl-proline hydroxylation (GO:0019511)2.32236513
107folic acid transport (GO:0015884)2.32223292
108misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.31975086
109hypotonic response (GO:0006971)2.30522738
110pteridine-containing compound metabolic process (GO:0042558)2.29439078
111hippo signaling (GO:0035329)2.28334305
112amino-acid betaine metabolic process (GO:0006577)2.28297108
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.27923315
114L-phenylalanine catabolic process (GO:0006559)2.27923315
115drug transmembrane transport (GO:0006855)2.27863638
116fatty acid oxidation (GO:0019395)2.27590263
117transcytosis (GO:0045056)2.27397208
118negative regulation of insulin secretion (GO:0046676)2.27016228
119notochord development (GO:0030903)2.26638886
120embryonic foregut morphogenesis (GO:0048617)2.25521634
121keratinization (GO:0031424)2.25451576
122cell-substrate junction assembly (GO:0007044)2.25389280
123homocysteine metabolic process (GO:0050667)2.24237691
124very-low-density lipoprotein particle assembly (GO:0034379)2.24198579
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.23702204
126establishment of apical/basal cell polarity (GO:0035089)2.23453531
127ER overload response (GO:0006983)2.23292020
128carnitine transmembrane transport (GO:1902603)2.22730488
129positive regulation of glycolytic process (GO:0045821)2.22641232
130regulation of meiosis I (GO:0060631)2.21685789
131negative regulation of DNA repair (GO:0045738)2.21508360
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21445000
133response to endoplasmic reticulum stress (GO:0034976)2.20805037
134sulfur amino acid biosynthetic process (GO:0000097)2.20423795
135serine family amino acid metabolic process (GO:0009069)2.19890599
136ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.19220220
137one-carbon metabolic process (GO:0006730)2.18881189
138mitotic cytokinesis (GO:0000281)2.17470765
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.14257944
140regulation of translational fidelity (GO:0006450)2.13313723
141regulation of keratinocyte proliferation (GO:0010837)2.12697374
142keratinocyte differentiation (GO:0030216)2.12223921
143genitalia morphogenesis (GO:0035112)2.11425655
144asymmetric protein localization (GO:0008105)2.10016829
145regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.09361863
146regulation of glucocorticoid metabolic process (GO:0031943)2.07018383
147morphogenesis of an epithelial sheet (GO:0002011)2.06831315
148negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.06069785
149regulation of mitotic spindle organization (GO:0060236)2.05981160
150membrane protein ectodomain proteolysis (GO:0006509)2.05773968
151muscle cell migration (GO:0014812)2.05654207
152regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.05060909
153cell-cell junction assembly (GO:0007043)2.04917957
154apical protein localization (GO:0045176)2.04162952
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.03278161
156endodermal cell differentiation (GO:0035987)2.02915773
157regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.02475720
158regulation of metalloenzyme activity (GO:0048552)2.02450325
159protein localization to microtubule (GO:0035372)2.02187738
160primary alcohol catabolic process (GO:0034310)2.01817054
161tight junction assembly (GO:0070830)2.01039984
162mitotic sister chromatid cohesion (GO:0007064)1.99252155
163copper ion homeostasis (GO:0055070)1.97458922
164multicellular organismal water homeostasis (GO:0050891)1.97058382
165wound healing, spreading of epidermal cells (GO:0035313)1.96701643
166cell surface receptor signaling pathway involved in heart development (GO:0061311)1.96332783
167mammary gland epithelial cell proliferation (GO:0033598)1.95153461
168Notch signaling involved in heart development (GO:0061314)1.94325667
169protein localization to cell surface (GO:0034394)1.93759019
170ventricular trabecula myocardium morphogenesis (GO:0003222)1.92625201
171regulation of keratinocyte differentiation (GO:0045616)1.91828869
172lipid particle organization (GO:0034389)1.91822813
173chondrocyte proliferation (GO:0035988)1.91792672
174positive regulation of mitochondrial calcium ion concentration (GO:0051561)1.90366267
175artery development (GO:0060840)1.90340486
176regulation of RNA export from nucleus (GO:0046831)1.89345368
177establishment of planar polarity (GO:0001736)1.89295795
178establishment of tissue polarity (GO:0007164)1.89295795
179embryonic heart tube development (GO:0035050)1.89036059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.02179208
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.94294042
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33676575
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.04188476
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98599782
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.82586343
7ZNF263_19887448_ChIP-Seq_K562_Human2.73874550
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.60051277
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.59166698
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54628637
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53188886
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35502772
13E2F7_22180533_ChIP-Seq_HELA_Human2.26851776
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18868350
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16381208
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15661973
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14297407
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.12832989
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10399046
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08422484
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08422484
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03302834
23AR_21909140_ChIP-Seq_LNCAP_Human2.00250029
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99677656
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88986397
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87008393
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85444592
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84892073
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84618191
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84144083
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.83744897
32* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.82543498
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81829098
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80675505
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80011825
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78812143
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77641101
38* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.76531565
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74639927
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72744695
41DCP1A_22483619_ChIP-Seq_HELA_Human1.72093818
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70219602
43CLOCK_20551151_ChIP-Seq_293T_Human1.69931300
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.69639222
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65163547
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62817923
47GABP_19822575_ChIP-Seq_HepG2_Human1.62353522
48* ATF3_27146783_Chip-Seq_COLON_Human1.61905113
49SOX2_20726797_ChIP-Seq_SW620_Human1.60159199
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59954592
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.58099252
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.55641356
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52797698
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52375167
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51874758
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51625727
57GATA1_22025678_ChIP-Seq_K562_Human1.51363326
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48789329
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48362083
60ELK1_19687146_ChIP-ChIP_HELA_Human1.48072529
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.47886032
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47763843
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.47331884
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.47138359
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46502641
66BRD4_25478319_ChIP-Seq_HGPS_Human1.46453528
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44829510
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43990428
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43970655
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42799290
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42772198
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41226703
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39825156
74CJUN_26792858_Chip-Seq_BT549_Human1.39034513
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38895172
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34734682
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.33542135
78XRN2_22483619_ChIP-Seq_HELA_Human1.33478671
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31624573
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30470596
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.30463966
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29505753
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28331418
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28321445
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27715171
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27084171
87VDR_23849224_ChIP-Seq_CD4+_Human1.26416878
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25831859
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24303609
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23160832
91KDM5A_27292631_Chip-Seq_BREAST_Human1.23040431
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22192263
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21072480
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20675201
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19081781
96* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18375885
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18281171
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17746848
99GATA6_25053715_ChIP-Seq_YYC3_Human1.17532515
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16968830
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16402643
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.16113701
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.14866278
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14693101
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13810866
106ELK1_22589737_ChIP-Seq_MCF10A_Human1.13533215
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13401185
108CHD1_26751641_Chip-Seq_LNCaP_Human1.13054230
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12863618
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12863618
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12811449
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12709821
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11756245
114GATA4_21415370_ChIP-Seq_HL-1_Mouse1.11572421
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11271061
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.10755267
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08971420
118UBF1/2_26484160_Chip-Seq_HMECs_Human1.08501265
119OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08049870
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08025421
121SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07564554
122TFEB_21752829_ChIP-Seq_HELA_Human1.06201819
123E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03522730
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03466379
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01914556
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00818080
127TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00768935
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00155860
129TP53_18474530_ChIP-ChIP_U2OS_Human1.00125407
130FOXP3_21729870_ChIP-Seq_TREG_Human0.99955751
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98627973
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.98521699
133* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98325719
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.98280122
135AHR_22903824_ChIP-Seq_MCF-7_Human0.97946699
136* GATA4_25053715_ChIP-Seq_YYC3_Human0.97636451
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97304475
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97282349
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97198379
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.97145370
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95852323
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95589972
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95003541
144TP63_23658742_ChIP-Seq_EP156T_Human0.94778264
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94632496
146TTF2_22483619_ChIP-Seq_HELA_Human0.93374132
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.92519357
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91789076
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91452413
150CIITA_25753668_ChIP-Seq_RAJI_Human0.91304063
151SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90365408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.41859293
2MP0003941_abnormal_skin_development3.39035337
3MP0004272_abnormal_basement_membrane3.24423016
4MP0003283_abnormal_digestive_organ3.05169665
5MP0002139_abnormal_hepatobiliary_system2.99861869
6MP0002837_dystrophic_cardiac_calcinosis2.98392800
7MP0005365_abnormal_bile_salt2.96979011
8MP0010234_abnormal_vibrissa_follicle2.80365845
9MP0003646_muscle_fatigue2.73400068
10MP0003693_abnormal_embryo_hatching2.60795874
11MP0002877_abnormal_melanocyte_morpholog2.58730753
12MP0002909_abnormal_adrenal_gland2.53532081
13MP0005085_abnormal_gallbladder_physiolo2.43487741
14MP0010030_abnormal_orbit_morphology2.43096643
15MP0003123_paternal_imprinting2.22996623
16MP0003195_calcinosis2.21275312
17MP0000013_abnormal_adipose_tissue2.16771438
18MP0004264_abnormal_extraembryonic_tissu2.14327395
19MP0004043_abnormal_pH_regulation2.11122483
20MP0004185_abnormal_adipocyte_glucose2.10616271
21MP0005670_abnormal_white_adipose2.07522322
22MP0010678_abnormal_skin_adnexa2.07245150
23MP0005275_abnormal_skin_tensile2.02466265
24MP0005666_abnormal_adipose_tissue2.02013721
25MP0004957_abnormal_blastocyst_morpholog1.97322695
26MP0008438_abnormal_cutaneous_collagen1.89731784
27MP0005360_urolithiasis1.87218999
28MP0005257_abnormal_intraocular_pressure1.84316598
29MP0000579_abnormal_nail_morphology1.84294500
30MP0005501_abnormal_skin_physiology1.82815878
31MP0010368_abnormal_lymphatic_system1.82106590
32MP0001944_abnormal_pancreas_morphology1.80232031
33MP0001666_abnormal_nutrient_absorption1.78128682
34MP0003950_abnormal_plasma_membrane1.71492903
35MP0002060_abnormal_skin_morphology1.69866559
36MP0002653_abnormal_ependyma_morphology1.65431845
37MP0003453_abnormal_keratinocyte_physiol1.64202560
38MP0005409_darkened_coat_color1.62968644
39MP0010329_abnormal_lipoprotein_level1.58245925
40MP0002693_abnormal_pancreas_physiology1.58000927
41MP0005375_adipose_tissue_phenotype1.57652750
42MP0003119_abnormal_digestive_system1.54859408
43MP0000383_abnormal_hair_follicle1.54044396
44MP0000762_abnormal_tongue_morphology1.52887028
45MP0009840_abnormal_foam_cell1.52542168
46MP0009780_abnormal_chondrocyte_physiolo1.51501406
47MP0000003_abnormal_adipose_tissue1.51414366
48MP0003868_abnormal_feces_composition1.50557380
49MP0005248_abnormal_Harderian_gland1.49654210
50MP0008875_abnormal_xenobiotic_pharmacok1.49421302
51MP0005220_abnormal_exocrine_pancreas1.49129265
52MP0002234_abnormal_pharynx_morphology1.48201002
53MP0010352_gastrointestinal_tract_polyps1.46859493
54MP0001216_abnormal_epidermal_layer1.46155127
55MP0005623_abnormal_meninges_morphology1.45890645
56MP0005023_abnormal_wound_healing1.44883458
57MP0002269_muscular_atrophy1.44479933
58MP0003705_abnormal_hypodermis_morpholog1.39632294
59MP0009643_abnormal_urine_homeostasis1.38878183
60MP0002098_abnormal_vibrissa_morphology1.35390680
61MP0003252_abnormal_bile_duct1.33465555
62MP0002078_abnormal_glucose_homeostasis1.33266332
63MP0009053_abnormal_anal_canal1.32634332
64MP0000566_synostosis1.32619009
65MP0000647_abnormal_sebaceous_gland1.31828566
66MP0005379_endocrine/exocrine_gland_phen1.30283890
67MP0000467_abnormal_esophagus_morphology1.29712419
68MP0000678_abnormal_parathyroid_gland1.28964217
69MP0009697_abnormal_copulation1.26970016
70MP0000609_abnormal_liver_physiology1.25063970
71MP0008932_abnormal_embryonic_tissue1.23639814
72MP0000462_abnormal_digestive_system1.20759193
73MP0004019_abnormal_vitamin_homeostasis1.20687456
74MP0002896_abnormal_bone_mineralization1.19718872
75MP0000377_abnormal_hair_follicle1.19276796
76MP0004084_abnormal_cardiac_muscle1.17831844
77MP0006036_abnormal_mitochondrial_physio1.16865062
78MP0003718_maternal_effect1.15781182
79MP0002697_abnormal_eye_size1.15683710
80MP0002233_abnormal_nose_morphology1.15124568
81MP0003191_abnormal_cellular_cholesterol1.13330820
82MP0004130_abnormal_muscle_cell1.10811644
83MP0000751_myopathy1.10331846
84MP0005332_abnormal_amino_acid1.09997618
85MP0002876_abnormal_thyroid_physiology1.09957286
86MP0004782_abnormal_surfactant_physiolog1.08766164
87MP0001765_abnormal_ion_homeostasis1.06287510
88MP0005319_abnormal_enzyme/_coenzyme1.05837359
89MP0010771_integument_phenotype1.05461499
90MP0001730_embryonic_growth_arrest1.05259214
91MP0000537_abnormal_urethra_morphology1.04975737
92MP0003755_abnormal_palate_morphology1.02812599
93MP0002118_abnormal_lipid_homeostasis1.02219459
94MP0000627_abnormal_mammary_gland1.01938559
95MP0004233_abnormal_muscle_weight1.01276775
96MP0001727_abnormal_embryo_implantation1.00057737
97MP0005083_abnormal_biliary_tract0.98573478
98MP0003937_abnormal_limbs/digits/tail_de0.98569199
99MP0003315_abnormal_perineum_morphology0.97764940
100MP0001756_abnormal_urination0.97507442
101MP0001879_abnormal_lymphatic_vessel0.97428400
102MP0004147_increased_porphyrin_level0.97381611
103MP0001299_abnormal_eye_distance/0.96316321
104MP0003077_abnormal_cell_cycle0.95569552
105MP0006072_abnormal_retinal_apoptosis0.94729405
106MP0005187_abnormal_penis_morphology0.94490508
107MP0005266_abnormal_metabolism0.91301180
108MP0000749_muscle_degeneration0.91022828
109MP0005636_abnormal_mineral_homeostasis0.90260560
110MP0005197_abnormal_uvea_morphology0.89491903
111MP0000750_abnormal_muscle_regeneration0.89132302
112MP0002089_abnormal_postnatal_growth/wei0.88376739
113MP0002796_impaired_skin_barrier0.87855288
114MP0002092_abnormal_eye_morphology0.87155912
115MP0003953_abnormal_hormone_level0.87149052
116MP0005076_abnormal_cell_differentiation0.86937993
117MP0004215_abnormal_myocardial_fiber0.85529847
118MP0004197_abnormal_fetal_growth/weight/0.85287385
119MP0008004_abnormal_stomach_pH0.84731469
120MP0005408_hypopigmentation0.84716455
121MP0003111_abnormal_nucleus_morphology0.84394745
122MP0001849_ear_inflammation0.83877145
123MP0000163_abnormal_cartilage_morphology0.82897425
124MP0005193_abnormal_anterior_eye0.82599136
125MP0000432_abnormal_head_morphology0.82409182
126MP0002084_abnormal_developmental_patter0.81899124
127MP0001697_abnormal_embryo_size0.81628632
128MP0000747_muscle_weakness0.80484235
129MP0003984_embryonic_growth_retardation0.80227413
130MP0005330_cardiomyopathy0.80067717
131MP0000358_abnormal_cell_content/0.79800493
132MP0003566_abnormal_cell_adhesion0.79725189
133MP0003385_abnormal_body_wall0.79694997
134MP0009672_abnormal_birth_weight0.79480363
135MP0002088_abnormal_embryonic_growth/wei0.79432025
136MP0001672_abnormal_embryogenesis/_devel0.77171825
137MP0005380_embryogenesis_phenotype0.77171825
138MP0002111_abnormal_tail_morphology0.76154404
139MP0008789_abnormal_olfactory_epithelium0.76094740
140MP0003091_abnormal_cell_migration0.75776725
141MP0002086_abnormal_extraembryonic_tissu0.75614607
142MP0003186_abnormal_redox_activity0.74824140
143MP0008007_abnormal_cellular_replicative0.74819996
144MP0002080_prenatal_lethality0.73879478
145MP0001293_anophthalmia0.73624516
146MP0004087_abnormal_muscle_fiber0.73618505
147MP0005165_increased_susceptibility_to0.73258761
148MP0000427_abnormal_hair_cycle0.72858333
149MP0010630_abnormal_cardiac_muscle0.71781216
150MP0000733_abnormal_muscle_development0.71477114
151MP0001243_abnormal_dermal_layer0.70982781
152MP0005395_other_phenotype0.70574066
153MP0003935_abnormal_craniofacial_develop0.70006632
154MP0000516_abnormal_urinary_system0.69971091
155MP0005367_renal/urinary_system_phenotyp0.69971091
156MP0004036_abnormal_muscle_relaxation0.69889858
157MP0002282_abnormal_trachea_morphology0.69041389
158MP0001929_abnormal_gametogenesis0.68919119
159MP0008877_abnormal_DNA_methylation0.68049113
160MP0005334_abnormal_fat_pad0.67813339
161MP0001661_extended_life_span0.67778102
162MP0006054_spinal_hemorrhage0.67570216
163MP0000613_abnormal_salivary_gland0.66459240
164MP0002085_abnormal_embryonic_tissue0.66123785

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)4.60381890
2Hypoglycemic coma (HP:0001325)4.35041252
3Hyperinsulinemic hypoglycemia (HP:0000825)4.20870934
4Metaphyseal cupping (HP:0003021)3.94656394
5Epiphyseal dysplasia (HP:0002656)3.91718188
6Flat acetabular roof (HP:0003180)3.83253026
7Hypoplastic ischia (HP:0003175)3.74397083
8Abnormal tarsal ossification (HP:0008369)3.67925506
9Hyperglycemia (HP:0003074)3.61986959
10Abnormal pancreas size (HP:0012094)3.60088114
11Insulin-resistant diabetes mellitus (HP:0000831)3.54074072
12Short nail (HP:0001799)3.48510273
13Vitreoretinal degeneration (HP:0000655)3.45715743
14Genu varum (HP:0002970)3.44504981
15Hypoglycemic seizures (HP:0002173)3.38254298
16Ketoacidosis (HP:0001993)3.36402997
17Abnormality of the ischium (HP:0003174)3.34477044
18Cupped ribs (HP:0000887)3.24724538
19Atrophic scars (HP:0001075)3.21917207
20Right ventricular cardiomyopathy (HP:0011663)3.14239077
21Arterial tortuosity (HP:0005116)3.10351375
22Flat capital femoral epiphysis (HP:0003370)3.08679557
23Late onset (HP:0003584)3.04901031
24Onycholysis (HP:0001806)2.96719938
25Symptomatic seizures (HP:0011145)2.93412833
26Hyperglycinuria (HP:0003108)2.92535228
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.90645713
28Insulin resistance (HP:0000855)2.82228408
29Abnormality of nail color (HP:0100643)2.81323285
30Hyperglycinemia (HP:0002154)2.78887280
31Vascular tortuosity (HP:0004948)2.78558417
32Premature rupture of membranes (HP:0001788)2.77726706
33Protuberant abdomen (HP:0001538)2.77150387
34Delayed epiphyseal ossification (HP:0002663)2.73216037
35Gout (HP:0001997)2.69681768
36Ketosis (HP:0001946)2.68943447
37Intrahepatic cholestasis (HP:0001406)2.65138569
38Aplasia cutis congenita (HP:0001057)2.64638108
39Papillary thyroid carcinoma (HP:0002895)2.62863420
40Pterygium (HP:0001059)2.59749718
41Osteolytic defects of the hand bones (HP:0009699)2.58953310
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.58953310
43Carpal bone hypoplasia (HP:0001498)2.56760428
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.51582763
45Increased serum pyruvate (HP:0003542)2.46490525
46Abnormal foot bone ossification (HP:0010675)2.45398821
47Small epiphyses (HP:0010585)2.43848880
48Natal tooth (HP:0000695)2.42423446
49Protrusio acetabuli (HP:0003179)2.42382790
50Abdominal distention (HP:0003270)2.42119886
51Irregular vertebral endplates (HP:0003301)2.39154335
52Flattened epiphyses (HP:0003071)2.36985757
53Abnormal cartilage morphology (HP:0002763)2.36250899
54Abnormality of glycolysis (HP:0004366)2.35531441
55Myoglobinuria (HP:0002913)2.35093370
56Vertebral clefting (HP:0008428)2.33791103
57Cervical subluxation (HP:0003308)2.31704275
58Abnormality of glycine metabolism (HP:0010895)2.31296338
59Abnormality of serine family amino acid metabolism (HP:0010894)2.31296338
60Hypoalphalipoproteinemia (HP:0003233)2.29510922
61Cardiovascular calcification (HP:0011915)2.26941191
62Abnormality of the intrinsic pathway (HP:0010989)2.25728655
63Generalized aminoaciduria (HP:0002909)2.25022906
64Vascular calcification (HP:0004934)2.22181368
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21738931
66Popliteal pterygium (HP:0009756)2.20983144
67Abnormality of the vertebral endplates (HP:0005106)2.19131846
68Alopecia of scalp (HP:0002293)2.17979251
69Ulnar deviation of the wrist (HP:0003049)2.17050196
70Abnormality of the pancreatic islet cells (HP:0006476)2.16412243
71Abnormality of endocrine pancreas physiology (HP:0012093)2.16412243
72Vertebral hypoplasia (HP:0008417)2.14171720
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.14171720
74Progressive muscle weakness (HP:0003323)2.13399056
75Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.12659831
76Abnormality of femoral epiphyses (HP:0006499)2.12659831
77Fragile skin (HP:0001030)2.11326615
78Testicular atrophy (HP:0000029)2.10450702
79Metaphyseal irregularity (HP:0003025)2.08628226
80Hypolipoproteinemia (HP:0010981)2.07914301
81Dicarboxylic aciduria (HP:0003215)2.05108647
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05108647
83Limb-girdle muscle atrophy (HP:0003797)2.04013152
84Secondary amenorrhea (HP:0000869)2.03473495
85Single umbilical artery (HP:0001195)2.02489265
86Abnormality of the fetal cardiovascular system (HP:0010948)2.02489265
87Abnormal umbilical cord blood vessels (HP:0011403)2.02489265
88Beaking of vertebral bodies (HP:0004568)2.00955942
89Abnormal biliary tract morphology (HP:0012440)2.00825663
90Abnormality of purine metabolism (HP:0004352)2.00782734
91Plantar hyperkeratosis (HP:0007556)2.00388791
92Palpitations (HP:0001962)1.98619523
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98475572
94Vertebral compression fractures (HP:0002953)1.98301118
95Hyperammonemia (HP:0001987)1.97834835
96Abnormalities of placenta or umbilical cord (HP:0001194)1.96879673
97Abnormality of the proximal phalanges of the hand (HP:0009834)1.96743413
98Rhabdomyolysis (HP:0003201)1.96562322
99Milia (HP:0001056)1.96424181
100Curly hair (HP:0002212)1.95662468
101Increased purine levels (HP:0004368)1.95572354
102Hyperuricemia (HP:0002149)1.95572354
103Abnormality of carpal bone ossification (HP:0006257)1.95526098
104Abnormality of the umbilical cord (HP:0010881)1.94264878
105Xanthomatosis (HP:0000991)1.92074350
106Absent eyelashes (HP:0000561)1.91372724
107Advanced eruption of teeth (HP:0006288)1.90900314
108Abnormality of the epiphysis of the femoral head (HP:0010574)1.90847510
109Microglossia (HP:0000171)1.90298146
110Abnormality of dentin (HP:0010299)1.89492947
111Long foot (HP:0001833)1.89460461
112Neonatal short-limb short stature (HP:0008921)1.88718806
113Abnormality of the acetabulum (HP:0003170)1.88664563
114Coxa vara (HP:0002812)1.88116636
115Hypoplastic pelvis (HP:0008839)1.87935935
116Enlarged epiphyses (HP:0010580)1.87912785
117Spinal cord compression (HP:0002176)1.87691231
118Hepatoblastoma (HP:0002884)1.86484089
119Abnormality of the distal phalanges of the toes (HP:0010182)1.86076495
120Fragile nails (HP:0001808)1.85941807
121Congenital ichthyosiform erythroderma (HP:0007431)1.85304412
122Thoracolumbar scoliosis (HP:0002944)1.85206084
123Neoplasm of the adrenal cortex (HP:0100641)1.83917746
124Hand muscle atrophy (HP:0009130)1.83581833
125Neoplasm of the adrenal gland (HP:0100631)1.83352929
126Nail dystrophy (HP:0008404)1.83343488
127Tetraparesis (HP:0002273)1.82594643
128Severe short stature (HP:0003510)1.82427548
129Platyspondyly (HP:0000926)1.82346583
130Biliary tract neoplasm (HP:0100574)1.81832424
131Sparse eyelashes (HP:0000653)1.77991393
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77420908
133Difficulty climbing stairs (HP:0003551)1.77259026
134Oligomenorrhea (HP:0000876)1.76763898
135Pili torti (HP:0003777)1.76671714
136Hypobetalipoproteinemia (HP:0003563)1.76557930
137Myopathic facies (HP:0002058)1.75790349
138Proximal tubulopathy (HP:0000114)1.75214447
139Wormian bones (HP:0002645)1.75172538
140Posterior subcapsular cataract (HP:0007787)1.73814661
141Lethargy (HP:0001254)1.72857968
142Missing ribs (HP:0000921)1.72636325
143Fat malabsorption (HP:0002630)1.71235769
144Rhinitis (HP:0012384)1.70803135
145Abnormality of serum amino acid levels (HP:0003112)1.70589067
146Increased connective tissue (HP:0009025)1.69156639
147Male infertility (HP:0003251)1.68996301
148Ventricular tachycardia (HP:0004756)1.68954973
149Muscle fiber splitting (HP:0003555)1.68614919
150Ankle contracture (HP:0006466)1.67739443
151Waddling gait (HP:0002515)1.67655318
152Aortic dissection (HP:0002647)1.67582064
153Abnormal vertebral ossification (HP:0100569)1.67466446
154Malnutrition (HP:0004395)1.66115537
155Osteoarthritis (HP:0002758)1.65541772
156Palmoplantar hyperkeratosis (HP:0000972)1.64742096
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.64664302
158Steatorrhea (HP:0002570)1.63916679
159Lip pit (HP:0100267)1.63689253
160Neonatal death (HP:0003811)1.61962131
161Absent frontal sinuses (HP:0002688)1.61379069
162Abnormal hand bone ossification (HP:0010660)1.61209322
163Abnormality of permanent molar morphology (HP:0011071)1.61081544
164Abnormality of the dental root (HP:0006486)1.61081544
165Taurodontia (HP:0000679)1.61081544
166Hypoplasia of dental enamel (HP:0006297)1.61031269
167Chronic bronchitis (HP:0004469)1.60113872
168Palmar hyperkeratosis (HP:0010765)1.58453438
169Trismus (HP:0000211)1.53790654
170Follicular hyperkeratosis (HP:0007502)1.53630756
171Thick nail (HP:0001805)1.53437406
172Thyroid carcinoma (HP:0002890)1.53368517
173Blepharitis (HP:0000498)1.52915909
174Abnormality of molar morphology (HP:0011070)1.52518985
175Abnormality of molar (HP:0011077)1.52518985
176Vertebral arch anomaly (HP:0008438)1.52436336
177Hypoplastic labia majora (HP:0000059)1.51233432
178Hyperactive renin-angiotensin system (HP:0000841)1.51145813
179Abnormality of the phalanges of the hallux (HP:0010057)1.50226436
180Abnormal ossification of hand bones (HP:0005921)1.49769943
181Capillary hemangiomas (HP:0005306)1.47527989
182Deviation of the thumb (HP:0009603)1.46928057
183Amniotic constriction ring (HP:0009775)1.45978454
184Abnormality of placental membranes (HP:0011409)1.45978454
185Mitral stenosis (HP:0001718)1.44387614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.47982925
2BCKDK3.22148937
3STK38L3.04757817
4PBK2.95368013
5MAP3K122.83146014
6PASK2.67944997
7MAP3K32.65157320
8INSRR2.53737930
9BRSK22.38413018
10PDK42.32833124
11PDK32.32833124
12TRIB32.30816524
13LATS12.02817441
14FRK2.02124927
15WEE11.90813998
16FLT31.87291605
17EPHB21.84204510
18MAPKAPK31.68890661
19NEK11.63961316
20NME11.63927594
21PDK21.57297477
22STK391.55830369
23AKT31.54355533
24MYLK1.50682883
25LMTK21.50520876
26TAOK21.47951435
27STK241.47580022
28ERBB31.46861765
29SIK11.46474835
30CDC71.46421422
31PRKD31.43980285
32TTK1.40781394
33MAP2K21.38950233
34MAP3K21.37274426
35PRKG21.35371302
36CDK121.35181799
37BUB11.31838689
38PRKCI1.30046264
39PKN21.29896484
40RIPK11.24728197
41RPS6KB21.24452882
42BRAF1.23342184
43TRPM71.20943560
44SRPK11.18074717
45ERN11.16731270
46KSR21.15224911
47DYRK31.14042567
48NME21.11102515
49NEK21.06803144
50PNCK1.04813309
51BRSK11.04426523
52MUSK0.99459552
53STK160.97696296
54KSR10.96854282
55MET0.95510281
56TAOK10.95417555
57BCR0.95312296
58PIK3CA0.92915038
59MAP3K110.92882654
60LATS20.92223450
61MAP2K10.91302459
62FER0.91301292
63SCYL20.89117076
64NEK60.88330942
65PAK20.87067646
66ILK0.86787413
67MST40.86558117
68ERBB40.86292050
69FGFR40.85750798
70TAOK30.85162839
71EEF2K0.85066686
72TESK10.84573506
73MAPK150.83319910
74AURKB0.82884316
75TGFBR20.81149713
76IRAK30.81122495
77PTK20.81067087
78PLK10.79373409
79HIPK20.78608021
80TIE10.78243486
81ICK0.77354718
82WNK30.76203972
83DMPK0.75760746
84DYRK1B0.75522284
85TTN0.74996414
86PLK40.74902970
87MST1R0.72875192
88CDK80.70427700
89FGFR10.69739484
90LIMK10.68317498
91MAP3K80.67909481
92STK30.66481918
93PDGFRA0.66420756
94MTOR0.65865670
95CDK70.65690529
96PTK60.65276607
97NEK90.65246241
98PRKAA10.65176292
99PAK40.64084083
100ARAF0.63572946
101MAP3K90.62524705
102CAMK1G0.62062749
103EIF2AK30.61805571
104AURKA0.59996493
105NTRK10.59670171
106MAP3K10.59084755
107MAP3K100.58973424
108MAPK110.58415518
109AKT20.57729717
110PAK30.56338698
111RPS6KA40.56092235
112PIM20.56081582
113PDGFRB0.53281999
114BRD40.52674985
115ABL20.52448771
116EIF2AK20.51662254
117DYRK20.50351209
118MAP3K50.48831498
119MAP3K40.46016405
120CDK40.43223840
121PLK20.43212579
122ROCK20.42955581
123EIF2AK10.39867095
124STK380.38873875
125MARK30.38564654
126TNIK0.38545554
127MELK0.37717969
128CHEK20.37717076
129ROCK10.37670355
130OBSCN0.37140525
131MKNK10.37049945
132MAP3K60.36926560
133BMX0.36681335
134MOS0.36419920
135MAP2K60.35708863
136PIK3CG0.35616062
137PLK30.32636172
138DDR20.31930084
139CDK90.31460068
140TSSK60.30778959
141CDK60.30139645
142CHEK10.30113641

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.11321611
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.24962695
3Sulfur metabolism_Homo sapiens_hsa009202.46175329
4Protein export_Homo sapiens_hsa030602.43253977
5Folate biosynthesis_Homo sapiens_hsa007902.42534250
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40378351
7Selenocompound metabolism_Homo sapiens_hsa004502.38315362
8Fatty acid degradation_Homo sapiens_hsa000712.15478663
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14281293
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11374420
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.07021169
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02485536
13Propanoate metabolism_Homo sapiens_hsa006401.89524072
14Steroid biosynthesis_Homo sapiens_hsa001001.80998358
15Pyruvate metabolism_Homo sapiens_hsa006201.78402968
16Adherens junction_Homo sapiens_hsa045201.76849424
17Fat digestion and absorption_Homo sapiens_hsa049751.73043956
18Fatty acid elongation_Homo sapiens_hsa000621.71431222
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68783745
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66750620
21Carbon metabolism_Homo sapiens_hsa012001.66100571
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63424333
23Non-homologous end-joining_Homo sapiens_hsa034501.56025754
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52076030
25Butanoate metabolism_Homo sapiens_hsa006501.47283476
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45318409
27Tryptophan metabolism_Homo sapiens_hsa003801.44905807
28Small cell lung cancer_Homo sapiens_hsa052221.40818728
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37388929
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.37284355
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34926045
32Galactose metabolism_Homo sapiens_hsa000521.34512771
33Biosynthesis of amino acids_Homo sapiens_hsa012301.32990890
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24450713
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24391636
36RNA transport_Homo sapiens_hsa030131.24182925
37Sphingolipid metabolism_Homo sapiens_hsa006001.23282813
38Fatty acid metabolism_Homo sapiens_hsa012121.22685989
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22301206
40Starch and sucrose metabolism_Homo sapiens_hsa005001.21395677
41One carbon pool by folate_Homo sapiens_hsa006701.20991492
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.20000486
43Arginine biosynthesis_Homo sapiens_hsa002201.17356002
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.16085954
45Hippo signaling pathway_Homo sapiens_hsa043901.15390314
46Focal adhesion_Homo sapiens_hsa045101.14913041
47Mineral absorption_Homo sapiens_hsa049781.14685594
48TGF-beta signaling pathway_Homo sapiens_hsa043501.14584020
49PPAR signaling pathway_Homo sapiens_hsa033201.13460257
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.11632796
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10108790
52Proteoglycans in cancer_Homo sapiens_hsa052051.08868998
53Protein digestion and absorption_Homo sapiens_hsa049741.07997715
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07100871
55Fructose and mannose metabolism_Homo sapiens_hsa000511.06830308
56Vitamin B6 metabolism_Homo sapiens_hsa007501.06510469
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05961935
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04531235
59Hedgehog signaling pathway_Homo sapiens_hsa043401.03760633
60Thyroid cancer_Homo sapiens_hsa052161.02550012
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01927053
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01273845
63Proteasome_Homo sapiens_hsa030501.00649316
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00450739
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.00255027
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96614457
67Basal cell carcinoma_Homo sapiens_hsa052170.93654472
68Glucagon signaling pathway_Homo sapiens_hsa049220.91382422
69Nitrogen metabolism_Homo sapiens_hsa009100.90972258
70Pentose phosphate pathway_Homo sapiens_hsa000300.87347142
71Peroxisome_Homo sapiens_hsa041460.85876383
72Regulation of autophagy_Homo sapiens_hsa041400.85629566
73Circadian rhythm_Homo sapiens_hsa047100.85268583
74beta-Alanine metabolism_Homo sapiens_hsa004100.84565269
75Glutathione metabolism_Homo sapiens_hsa004800.83303487
76Pyrimidine metabolism_Homo sapiens_hsa002400.83071200
77Insulin resistance_Homo sapiens_hsa049310.82975491
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82880245
79RNA polymerase_Homo sapiens_hsa030200.82067446
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.81535470
81Insulin secretion_Homo sapiens_hsa049110.80109184
82Arginine and proline metabolism_Homo sapiens_hsa003300.79567661
83Glycerolipid metabolism_Homo sapiens_hsa005610.79249608
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77362053
85AMPK signaling pathway_Homo sapiens_hsa041520.76530861
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76490626
87Cell cycle_Homo sapiens_hsa041100.72984656
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72503619
89Bladder cancer_Homo sapiens_hsa052190.72215442
90Sulfur relay system_Homo sapiens_hsa041220.71553943
91Amoebiasis_Homo sapiens_hsa051460.70536020
92Nucleotide excision repair_Homo sapiens_hsa034200.68108699
93N-Glycan biosynthesis_Homo sapiens_hsa005100.65162401
94Linoleic acid metabolism_Homo sapiens_hsa005910.64647756
95Insulin signaling pathway_Homo sapiens_hsa049100.64558328
96Renal cell carcinoma_Homo sapiens_hsa052110.63769711
97Dilated cardiomyopathy_Homo sapiens_hsa054140.62624497
98Mismatch repair_Homo sapiens_hsa034300.62401497
99Other glycan degradation_Homo sapiens_hsa005110.62191368
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61395612
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60685778
102DNA replication_Homo sapiens_hsa030300.60640046
103Vibrio cholerae infection_Homo sapiens_hsa051100.59415724
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59244585
105Endometrial cancer_Homo sapiens_hsa052130.57764270
106Metabolic pathways_Homo sapiens_hsa011000.57366869
107MicroRNAs in cancer_Homo sapiens_hsa052060.57357900
108Phenylalanine metabolism_Homo sapiens_hsa003600.56555192
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.55290347
110Lysine degradation_Homo sapiens_hsa003100.54878006
111Purine metabolism_Homo sapiens_hsa002300.54448759
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52875270
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52311441
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.51743099
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51184681
116Vitamin digestion and absorption_Homo sapiens_hsa049770.50915961
117Chemical carcinogenesis_Homo sapiens_hsa052040.50507517
118Bile secretion_Homo sapiens_hsa049760.50190067
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47420969
120ECM-receptor interaction_Homo sapiens_hsa045120.46858631
121Histidine metabolism_Homo sapiens_hsa003400.46003329
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43814838
123Tight junction_Homo sapiens_hsa045300.43278468
124Basal transcription factors_Homo sapiens_hsa030220.42976048
125Huntingtons disease_Homo sapiens_hsa050160.42837899
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41198541
127p53 signaling pathway_Homo sapiens_hsa041150.38670745
128Type II diabetes mellitus_Homo sapiens_hsa049300.37155521
129Tyrosine metabolism_Homo sapiens_hsa003500.36658014
130Thyroid hormone synthesis_Homo sapiens_hsa049180.35935448
131Ribosome_Homo sapiens_hsa030100.35165132
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35135711
133Spliceosome_Homo sapiens_hsa030400.35062963
134Oocyte meiosis_Homo sapiens_hsa041140.34477483
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.34032107

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