DHX33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.01439136
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.28008311
3monoubiquitinated protein deubiquitination (GO:0035520)6.23055804
4regulation of spindle organization (GO:0090224)5.50395966
5metaphase plate congression (GO:0051310)5.44801394
6protein localization to kinetochore (GO:0034501)5.42657589
7nuclear pore complex assembly (GO:0051292)5.39919819
8regulation of RNA export from nucleus (GO:0046831)5.36158932
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.22209995
10regulation of establishment of cell polarity (GO:2000114)5.20318904
11nuclear pore organization (GO:0006999)5.14744015
12protein localization to chromosome, centromeric region (GO:0071459)5.07988623
13lens morphogenesis in camera-type eye (GO:0002089)4.88718616
14mitotic chromosome condensation (GO:0007076)4.85509978
15regulation of retinoic acid receptor signaling pathway (GO:0048385)4.83696030
16mitotic sister chromatid cohesion (GO:0007064)4.82943147
17snRNA transcription (GO:0009301)4.70450070
18regulation of sister chromatid cohesion (GO:0007063)4.68681816
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.55878752
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.53099056
21positive regulation of chromosome segregation (GO:0051984)4.48172550
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.46070153
23regulation of nucleobase-containing compound transport (GO:0032239)4.40246545
24DNA damage response, signal transduction resulting in transcription (GO:0042772)4.39393494
25DNA strand elongation involved in DNA replication (GO:0006271)4.39036688
26regulation of establishment or maintenance of cell polarity (GO:0032878)4.37939050
27regulation of mitotic spindle organization (GO:0060236)4.36095031
28histone H2A monoubiquitination (GO:0035518)4.35546048
29protein K6-linked ubiquitination (GO:0085020)4.34037273
30establishment of chromosome localization (GO:0051303)4.32762851
31DNA replication checkpoint (GO:0000076)4.31306675
32folic acid-containing compound biosynthetic process (GO:0009396)4.27248080
33protein localization to chromosome (GO:0034502)4.26704692
34IMP biosynthetic process (GO:0006188)4.20859685
35DNA strand elongation (GO:0022616)4.20131355
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.19357868
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.19357868
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.19357868
39regulation of exit from mitosis (GO:0007096)4.19251874
40meiotic chromosome segregation (GO:0045132)4.15907482
41regulation of meiosis I (GO:0060631)4.13293893
42negative regulation of DNA-dependent DNA replication (GO:2000104)4.09322676
43purine nucleobase biosynthetic process (GO:0009113)4.05898910
44establishment of integrated proviral latency (GO:0075713)4.05591903
45mitotic nuclear envelope disassembly (GO:0007077)4.01991376
46sister chromatid cohesion (GO:0007062)3.97808663
47telomere maintenance via semi-conservative replication (GO:0032201)3.97717364
48DNA unwinding involved in DNA replication (GO:0006268)3.94954302
49inner cell mass cell proliferation (GO:0001833)3.91391604
50resolution of meiotic recombination intermediates (GO:0000712)3.85721365
51regulation of telomere maintenance via telomerase (GO:0032210)3.80029629
52negative regulation of keratinocyte proliferation (GO:0010839)3.79984693
53nuclear envelope disassembly (GO:0051081)3.77595484
54membrane disassembly (GO:0030397)3.77595484
55regulation of DNA endoreduplication (GO:0032875)3.77188972
56pore complex assembly (GO:0046931)3.76736841
57heterochromatin organization (GO:0070828)3.71542029
58IMP metabolic process (GO:0046040)3.67964092
59nucleobase biosynthetic process (GO:0046112)3.66934434
60meiosis I (GO:0007127)3.60067437
61oocyte maturation (GO:0001556)3.57508350
62microtubule depolymerization (GO:0007019)3.57341037
63response to UV-C (GO:0010225)3.53257248
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.50961455
65regulation of chromosome segregation (GO:0051983)3.50168543
66microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.48266379
67ribosome biogenesis (GO:0042254)3.47600378
68histone exchange (GO:0043486)3.47026229
69male meiosis I (GO:0007141)3.43719233
70telomere maintenance via recombination (GO:0000722)3.43567853
71mitotic sister chromatid segregation (GO:0000070)3.41364050
72histone H2A ubiquitination (GO:0033522)3.40710032
73ribosome assembly (GO:0042255)3.35758940
74negative regulation of cell aging (GO:0090344)3.35461645
75histone demethylation (GO:0016577)3.33415120
76mitotic recombination (GO:0006312)3.32762287
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.30545252
78kinetochore organization (GO:0051383)3.27394416
79histone lysine demethylation (GO:0070076)3.26901337
80regulation of translational fidelity (GO:0006450)3.25451587
81DNA replication-independent nucleosome organization (GO:0034724)3.24379549
82DNA replication-independent nucleosome assembly (GO:0006336)3.24379549
83folic acid metabolic process (GO:0046655)3.24272732
84chromosome segregation (GO:0007059)3.23755851
85pentose-phosphate shunt (GO:0006098)3.23713955
86DNA replication-dependent nucleosome assembly (GO:0006335)3.23039690
87DNA replication-dependent nucleosome organization (GO:0034723)3.23039690
88synaptonemal complex assembly (GO:0007130)3.22493671
89negative regulation of hormone biosynthetic process (GO:0032353)3.21449623
90negative regulation of hormone metabolic process (GO:0032351)3.21449623
91negative regulation of translation, ncRNA-mediated (GO:0040033)3.20321842
92regulation of translation, ncRNA-mediated (GO:0045974)3.20321842
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20321842
94regulation of centriole replication (GO:0046599)3.16651984
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.15831615
96somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15831615
97centrosome duplication (GO:0051298)3.14034990
98CENP-A containing nucleosome assembly (GO:0034080)3.12688649
99replication fork processing (GO:0031297)3.12482657
100double-strand break repair via nonhomologous end joining (GO:0006303)3.12219643
101non-recombinational repair (GO:0000726)3.12219643
102spindle checkpoint (GO:0031577)3.11220681
103protein dealkylation (GO:0008214)3.11080161
104protein demethylation (GO:0006482)3.11080161
105mitochondrial RNA metabolic process (GO:0000959)3.10930244
106L-serine metabolic process (GO:0006563)3.10019907
107positive regulation of protein import into nucleus, translocation (GO:0033160)3.09964689
108tetrahydrofolate metabolic process (GO:0046653)3.08874285
109glucose catabolic process (GO:0006007)3.08533966
110chromatin remodeling at centromere (GO:0031055)3.07682541
111sister chromatid segregation (GO:0000819)3.07155761
112corticosteroid receptor signaling pathway (GO:0031958)3.06794100
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.05283333
114attachment of spindle microtubules to kinetochore (GO:0008608)3.04155126
115kinetochore assembly (GO:0051382)3.04023140
116DNA damage induced protein phosphorylation (GO:0006975)3.03911888
117telomere maintenance via telomere lengthening (GO:0010833)3.03674835
118spindle assembly involved in mitosis (GO:0090307)3.03304580
119NLS-bearing protein import into nucleus (GO:0006607)3.03224453
120pseudouridine synthesis (GO:0001522)3.02582013
121negative regulation of fibroblast apoptotic process (GO:2000270)3.02522934
122DNA double-strand break processing (GO:0000729)3.01894197
123negative regulation of telomere maintenance (GO:0032205)3.01804616
124negative regulation of DNA replication (GO:0008156)3.01584920
125nucleus organization (GO:0006997)2.99337069
126vitamin transmembrane transport (GO:0035461)2.98078391
127regulation of translational termination (GO:0006449)2.96854135
128spliceosomal snRNP assembly (GO:0000387)2.96308924
129meiotic cell cycle process (GO:1903046)2.95993021
130regulation of DNA-dependent DNA replication (GO:0090329)2.95838326
131pteridine-containing compound biosynthetic process (GO:0042559)2.95535257
132negative regulation of chromosome segregation (GO:0051985)2.94435189
133nuclear envelope organization (GO:0006998)2.94215626
134protein complex localization (GO:0031503)2.93600667
135pre-miRNA processing (GO:0031054)2.93543439
136dosage compensation (GO:0007549)2.92978993
137synapsis (GO:0007129)2.92542571
138histone H3-K9 demethylation (GO:0033169)2.91608101
139DNA replication initiation (GO:0006270)2.91439629
140DNA catabolic process, exonucleolytic (GO:0000738)2.91367455
141negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91095891
142regulation of hippo signaling (GO:0035330)2.90847574
143ATP-dependent chromatin remodeling (GO:0043044)2.89931425
144negative regulation of telomerase activity (GO:0051974)2.89846496
145telomere maintenance via telomerase (GO:0007004)2.88829821
146mitotic spindle checkpoint (GO:0071174)2.88793074
147amino acid activation (GO:0043038)2.88730259
148tRNA aminoacylation (GO:0043039)2.88730259
149somatic recombination of immunoglobulin gene segments (GO:0016447)2.88468356
150DNA strand renaturation (GO:0000733)2.88130344
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88018401
152anterior/posterior axis specification, embryo (GO:0008595)2.87152834
153maturation of 5.8S rRNA (GO:0000460)2.85688261
154formation of translation preinitiation complex (GO:0001731)2.85271320
155negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85118406
156negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85118406
157negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85118406
158negative regulation of mitotic sister chromatid separation (GO:2000816)2.85118406
159negative regulation of sister chromatid segregation (GO:0033046)2.85118406
160tRNA aminoacylation for protein translation (GO:0006418)2.85015219
161negative regulation of mRNA processing (GO:0050686)2.84907809
162rRNA processing (GO:0006364)2.84020453
163DNA duplex unwinding (GO:0032508)2.81777094
164DNA topological change (GO:0006265)2.81197669
165regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80866767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94866902
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.10126243
3FOXM1_23109430_ChIP-Seq_U2OS_Human6.65180369
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82404816
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71338190
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70619004
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64903368
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.45372409
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.38444401
10AR_21909140_ChIP-Seq_LNCAP_Human3.19072847
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.08969263
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.03023069
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.94311322
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.78972940
15* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71250139
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.56354523
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46885162
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.44688397
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42830973
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.16149824
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15131745
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11994792
23ELK1_19687146_ChIP-ChIP_HELA_Human2.09739300
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06450865
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01863790
26TTF2_22483619_ChIP-Seq_HELA_Human1.99730491
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97099921
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96686384
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89802774
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.87762415
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85915491
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84429218
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74786632
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71750277
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71686120
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66985454
37MYC_22102868_ChIP-Seq_BL_Human1.65189786
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61361204
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61074407
40DCP1A_22483619_ChIP-Seq_HELA_Human1.60241717
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.59011009
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58385851
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51836743
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47472826
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47207805
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46011884
47KDM5A_27292631_Chip-Seq_BREAST_Human1.45866801
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45079944
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43451056
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40615158
51ZNF263_19887448_ChIP-Seq_K562_Human1.40469127
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40231393
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.39058983
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.36856411
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35541798
56XRN2_22483619_ChIP-Seq_HELA_Human1.34569003
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30512785
58SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29622476
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24806892
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.24415825
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.22740226
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22206195
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21496801
64* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20118366
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18159934
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16634340
67EWS_26573619_Chip-Seq_HEK293_Human1.16496204
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15820111
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.13490970
70* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12768129
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12248943
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11647342
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09266554
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09184213
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08642767
76ZNF274_21170338_ChIP-Seq_K562_Hela1.08609099
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08037362
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05926569
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04983882
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04533172
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02267192
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00835642
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99121527
84TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98161477
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98004421
86PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97724219
87VDR_23849224_ChIP-Seq_CD4+_Human0.97095698
88KAP1_27257070_Chip-Seq_ESCs_Mouse0.96056478
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95202776
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95043537
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.94748993
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94376778
93* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94213198
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93711525
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92913786
96ATF3_27146783_Chip-Seq_COLON_Human0.92297372
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91592588
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91592588
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90967560
100* ETS1_20019798_ChIP-Seq_JURKAT_Human0.90499099
101MYC_18940864_ChIP-ChIP_HL60_Human0.90087219
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89597544
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.87747779
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87653262
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87481346
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85349778
107IRF1_19129219_ChIP-ChIP_H3396_Human0.84318001
108FUS_26573619_Chip-Seq_HEK293_Human0.83239196
109TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83124419
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.83070802
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81281900
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80147170
113VDR_22108803_ChIP-Seq_LS180_Human0.79941911
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79329117
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79110520
116UBF1/2_26484160_Chip-Seq_HMECs_Human0.78318376
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78061829
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76496369
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75346265
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75220043
121FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75047984
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74746940
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74736181
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.74669250
125GABP_19822575_ChIP-Seq_HepG2_Human0.74380601
126CHD1_26751641_Chip-Seq_LNCaP_Human0.74194170
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73509224
128CIITA_25753668_ChIP-Seq_RAJI_Human0.73323891
129TCF7_22412390_ChIP-Seq_EML_Mouse0.73031044
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72366478
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72053167
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.70819839
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70665874
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69799450
135TBL1_22424771_ChIP-Seq_293T_Human0.69785956
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.69386737
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.68839965
138GABP_17652178_ChIP-ChIP_JURKAT_Human0.68611965
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.68088995
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68088995
141POU5F1_16518401_ChIP-PET_MESCs_Mouse0.67632582
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.67187844
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.66330745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.22413451
2MP0008057_abnormal_DNA_replication4.13102983
3MP0003111_abnormal_nucleus_morphology3.93916759
4MP0008007_abnormal_cellular_replicative3.79573988
5MP0003077_abnormal_cell_cycle3.57448714
6MP0010094_abnormal_chromosome_stability3.48158329
7MP0006292_abnormal_olfactory_placode3.45595231
8MP0010307_abnormal_tumor_latency3.17931452
9MP0004957_abnormal_blastocyst_morpholog2.97413553
10MP0008877_abnormal_DNA_methylation2.90111828
11MP0001730_embryonic_growth_arrest2.62135712
12MP0008058_abnormal_DNA_repair2.36659546
13MP0000350_abnormal_cell_proliferation2.29369491
14MP0003123_paternal_imprinting2.28593155
15MP0005076_abnormal_cell_differentiation2.21131846
16MP0002396_abnormal_hematopoietic_system2.18397273
17MP0001672_abnormal_embryogenesis/_devel2.10905245
18MP0005380_embryogenesis_phenotype2.10905245
19MP0004185_abnormal_adipocyte_glucose2.10459103
20MP0005451_abnormal_body_composition2.07876221
21MP0002653_abnormal_ependyma_morphology1.99290857
22MP0002938_white_spotting1.96070532
23MP0003941_abnormal_skin_development1.95567933
24MP0003937_abnormal_limbs/digits/tail_de1.92394073
25MP0002084_abnormal_developmental_patter1.91209296
26MP0003984_embryonic_growth_retardation1.89927520
27MP0003718_maternal_effect1.87799183
28MP0002085_abnormal_embryonic_tissue1.83823815
29MP0002088_abnormal_embryonic_growth/wei1.82476479
30MP0001697_abnormal_embryo_size1.78447153
31MP0000566_synostosis1.77192325
32MP0002086_abnormal_extraembryonic_tissu1.66744112
33MP0005408_hypopigmentation1.65920295
34MP0002102_abnormal_ear_morphology1.65788240
35MP0003119_abnormal_digestive_system1.52885159
36MP0000049_abnormal_middle_ear1.47271901
37MP0008932_abnormal_embryonic_tissue1.45893213
38MP0009672_abnormal_birth_weight1.41765773
39MP0002080_prenatal_lethality1.41600908
40MP0002210_abnormal_sex_determination1.40667691
41MP0002160_abnormal_reproductive_system1.39192364
42MP0004808_abnormal_hematopoietic_stem1.37517406
43MP0001286_abnormal_eye_development1.35020772
44MP0009697_abnormal_copulation1.31840507
45MP0009333_abnormal_splenocyte_physiolog1.31640972
46MP0005647_abnormal_sex_gland1.30580126
47MP0001929_abnormal_gametogenesis1.30066179
48MP0003787_abnormal_imprinting1.28449931
49MP0004197_abnormal_fetal_growth/weight/1.28239469
50MP0010352_gastrointestinal_tract_polyps1.27900448
51MP0003935_abnormal_craniofacial_develop1.23779056
52MP0000653_abnormal_sex_gland1.23022120
53MP0003705_abnormal_hypodermis_morpholog1.22461404
54MP0001145_abnormal_male_reproductive1.21198715
55MP0000537_abnormal_urethra_morphology1.19680373
56MP0005187_abnormal_penis_morphology1.18950673
57MP0000428_abnormal_craniofacial_morphol1.17701455
58MP0003755_abnormal_palate_morphology1.16863848
59MP0003699_abnormal_female_reproductive1.16710170
60MP0002877_abnormal_melanocyte_morpholog1.15881251
61MP0001119_abnormal_female_reproductive1.15397262
62MP0002111_abnormal_tail_morphology1.14570712
63MP0003890_abnormal_embryonic-extraembry1.13460231
64MP0003121_genomic_imprinting1.13167259
65MP0004264_abnormal_extraembryonic_tissu1.11789557
66MP0000372_irregular_coat_pigmentation1.07049804
67MP0003938_abnormal_ear_development1.06776894
68MP0001485_abnormal_pinna_reflex1.05758134
69MP0006035_abnormal_mitochondrial_morpho1.04900485
70MP0005397_hematopoietic_system_phenotyp1.02351533
71MP0001545_abnormal_hematopoietic_system1.02351533
72MP0003115_abnormal_respiratory_system1.02191417
73MP0010234_abnormal_vibrissa_follicle0.99945798
74MP0002751_abnormal_autonomic_nervous0.99528503
75MP0010030_abnormal_orbit_morphology0.99352919
76MP0001849_ear_inflammation0.98534032
77MP0005621_abnormal_cell_physiology0.98468758
78MP0005248_abnormal_Harderian_gland0.98272555
79MP0001188_hyperpigmentation0.96076479
80MP0001661_extended_life_span0.95415702
81MP0002254_reproductive_system_inflammat0.95319370
82MP0002019_abnormal_tumor_incidence0.93912075
83MP0009703_decreased_birth_body0.91465361
84MP0002163_abnormal_gland_morphology0.91410404
85MP0000569_abnormal_digit_pigmentation0.91240423
86MP0001529_abnormal_vocalization0.90644574
87MP0000627_abnormal_mammary_gland0.90062176
88MP0003828_pulmonary_edema0.89646830
89MP0004133_heterotaxia0.89631584
90MP0003567_abnormal_fetal_cardiomyocyte0.89299203
91MP0009053_abnormal_anal_canal0.89252955
92MP0001346_abnormal_lacrimal_gland0.89196073
93MP0004233_abnormal_muscle_weight0.89049271
94MP0003861_abnormal_nervous_system0.88789546
95MP0000579_abnormal_nail_morphology0.88429591
96MP0003136_yellow_coat_color0.88384746
97MP0008789_abnormal_olfactory_epithelium0.86575997
98MP0008995_early_reproductive_senescence0.86320067
99MP0001293_anophthalmia0.86294579
100MP0000432_abnormal_head_morphology0.85990244
101MP0003942_abnormal_urinary_system0.85733585
102MP0001915_intracranial_hemorrhage0.85641151
103MP0005395_other_phenotype0.84593518
104MP0005197_abnormal_uvea_morphology0.84503442
105MP0002233_abnormal_nose_morphology0.84326657
106MP0002234_abnormal_pharynx_morphology0.83446074
107MP0000631_abnormal_neuroendocrine_gland0.82871804
108MP0002697_abnormal_eye_size0.82705099
109MP0002925_abnormal_cardiovascular_devel0.82503538
110MP0003221_abnormal_cardiomyocyte_apopto0.81154404
111MP0000490_abnormal_crypts_of0.80525479
112MP0000733_abnormal_muscle_development0.80503035
113MP0005075_abnormal_melanosome_morpholog0.79232714
114MP0005389_reproductive_system_phenotype0.77706496
115MP0003315_abnormal_perineum_morphology0.77032695
116MP0000313_abnormal_cell_death0.76812770
117MP0003385_abnormal_body_wall0.76289589
118MP0005666_abnormal_adipose_tissue0.75940745
119MP0003786_premature_aging0.74600024
120MP0006072_abnormal_retinal_apoptosis0.74517585
121MP0000358_abnormal_cell_content/0.74512479
122MP0003646_muscle_fatigue0.74473684
123MP0000647_abnormal_sebaceous_gland0.73788934
124MP0002177_abnormal_outer_ear0.71790368
125MP0000762_abnormal_tongue_morphology0.71408601
126MP0003950_abnormal_plasma_membrane0.71098143
127MP0009250_abnormal_appendicular_skeleto0.69501312
128MP0008770_decreased_survivor_rate0.69061858
129MP0005670_abnormal_white_adipose0.68894917
130MP0003936_abnormal_reproductive_system0.68328562
131MP0005384_cellular_phenotype0.68297983
132MP0002116_abnormal_craniofacial_bone0.67704042
133MP0002249_abnormal_larynx_morphology0.67692483
134MP0005394_taste/olfaction_phenotype0.67572095
135MP0005499_abnormal_olfactory_system0.67572095
136MP0002092_abnormal_eye_morphology0.66823875
137MP0003806_abnormal_nucleotide_metabolis0.65403204

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)6.51730002
2Capillary hemangiomas (HP:0005306)4.83669051
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.73071093
4Birth length less than 3rd percentile (HP:0003561)4.57813491
5Chromsome breakage (HP:0040012)4.46109347
6Prostate neoplasm (HP:0100787)4.34924652
7Abnormality of the labia minora (HP:0012880)4.07242549
8Papillary thyroid carcinoma (HP:0002895)3.92409311
9Oligodactyly (HP:0012165)3.45605196
10Patellar aplasia (HP:0006443)3.39723967
11Breast hypoplasia (HP:0003187)3.37757781
12Meckel diverticulum (HP:0002245)3.36251515
13Neoplasm of the adrenal cortex (HP:0100641)3.29748238
14Acute myeloid leukemia (HP:0004808)3.21538997
15Microglossia (HP:0000171)3.18843690
16Oligodactyly (hands) (HP:0001180)3.15274518
17Aplasia/Hypoplasia of the patella (HP:0006498)3.12883436
18Abnormality of the ileum (HP:0001549)3.11270558
19Abnormality of chromosome stability (HP:0003220)3.10381246
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.09333112
21Stenosis of the external auditory canal (HP:0000402)3.04753966
22Abnormality of the preputium (HP:0100587)3.01870782
23Sensorimotor neuropathy (HP:0007141)2.96125102
24Shawl scrotum (HP:0000049)2.94277549
25Colon cancer (HP:0003003)2.84016655
26Abnormal lung lobation (HP:0002101)2.83794572
27Acute lymphatic leukemia (HP:0006721)2.82922174
28Azoospermia (HP:0000027)2.81884285
29Abnormality of the fingertips (HP:0001211)2.80761331
30Ependymoma (HP:0002888)2.80219269
31Breast aplasia (HP:0100783)2.78652733
32Absent thumb (HP:0009777)2.74066533
33Impulsivity (HP:0100710)2.72564552
34Reticulocytopenia (HP:0001896)2.72307383
35Spontaneous abortion (HP:0005268)2.68748741
36Enlarged penis (HP:0000040)2.66122712
37Rectal fistula (HP:0100590)2.63000316
38Rectovaginal fistula (HP:0000143)2.63000316
39Aplasia/Hypoplasia of the breasts (HP:0010311)2.57503527
40Short 4th metacarpal (HP:0010044)2.57116859
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57116859
42Long eyelashes (HP:0000527)2.52405156
43Abnormal spermatogenesis (HP:0008669)2.48966815
44Male infertility (HP:0003251)2.46336231
45Ectopic kidney (HP:0000086)2.44723101
46Myelodysplasia (HP:0002863)2.44216457
47Triphalangeal thumb (HP:0001199)2.43418127
48Increased nuchal translucency (HP:0010880)2.41979707
49Multiple enchondromatosis (HP:0005701)2.40759253
50Ankle contracture (HP:0006466)2.40345634
51Abnormality of the prostate (HP:0008775)2.37369600
52Short thumb (HP:0009778)2.36171842
53Abnormality of lateral ventricle (HP:0030047)2.33113640
54Abnormality of the carotid arteries (HP:0005344)2.31913854
55Abnormality of cochlea (HP:0000375)2.31325387
56Thyroid carcinoma (HP:0002890)2.30377985
57Carpal bone hypoplasia (HP:0001498)2.30329082
58Overlapping toe (HP:0001845)2.29198853
59Volvulus (HP:0002580)2.27095929
60Prominent nose (HP:0000448)2.24464728
61Wrist flexion contracture (HP:0001239)2.24400016
62Duodenal stenosis (HP:0100867)2.24397585
63Small intestinal stenosis (HP:0012848)2.24397585
64Intestinal fistula (HP:0100819)2.24247032
65Arteriovenous malformation (HP:0100026)2.20775565
66Proximal placement of thumb (HP:0009623)2.20029674
67Deviation of the thumb (HP:0009603)2.19728722
68Abnormality of DNA repair (HP:0003254)2.17947433
69Sloping forehead (HP:0000340)2.17147432
70Neoplasm of the adrenal gland (HP:0100631)2.15621656
71Duplicated collecting system (HP:0000081)2.14146083
72Vaginal fistula (HP:0004320)2.13944928
73Abnormal number of incisors (HP:0011064)2.13692335
74Abnormality of the renal collecting system (HP:0004742)2.12667315
75Sandal gap (HP:0001852)2.12381363
76Heterotopia (HP:0002282)2.11595039
77Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09947615
78Short 1st metacarpal (HP:0010034)2.09947615
79Abnormality of chromosome segregation (HP:0002916)2.09620158
80Oral leukoplakia (HP:0002745)2.04815568
81Glioma (HP:0009733)2.04750887
82Cafe-au-lait spot (HP:0000957)2.04567798
83Abnormality of the hepatic vasculature (HP:0006707)2.03733701
84Pendular nystagmus (HP:0012043)2.03183354
85Supernumerary spleens (HP:0009799)2.02548451
86Broad thumb (HP:0011304)2.01847611
87Clubbing of toes (HP:0100760)2.01678780
88Astrocytoma (HP:0009592)2.01657807
89Absent radius (HP:0003974)2.00800694
90Sensory axonal neuropathy (HP:0003390)2.00681879
91Shallow orbits (HP:0000586)1.99566920
92Tracheoesophageal fistula (HP:0002575)1.97434374
93Abnormality of the phalanges of the hallux (HP:0010057)1.97321741
94Bilateral microphthalmos (HP:0007633)1.95437843
95Rib fusion (HP:0000902)1.93666778
96Genu recurvatum (HP:0002816)1.91858021
97Nephroblastoma (Wilms tumor) (HP:0002667)1.91602761
98Myocardial infarction (HP:0001658)1.91210118
99Abnormality of male internal genitalia (HP:0000022)1.91173800
100Renal agenesis (HP:0000104)1.90256833
101Absent forearm bone (HP:0003953)1.87928278
102Aplasia involving forearm bones (HP:0009822)1.87928278
103Horseshoe kidney (HP:0000085)1.87209964
104Optic nerve coloboma (HP:0000588)1.86817171
105Esophageal atresia (HP:0002032)1.86285278
106Complete atrioventricular canal defect (HP:0001674)1.85300340
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.85286873
108Delayed puberty (HP:0000823)1.84374918
109Urethral obstruction (HP:0000796)1.83870496
110Abnormality of the duodenum (HP:0002246)1.83601603
111Rhabdomyosarcoma (HP:0002859)1.81676240
112Abnormality of the parathyroid morphology (HP:0011766)1.81088600
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80145316
114Embryonal renal neoplasm (HP:0011794)1.78511510
115Abnormality of the 4th metacarpal (HP:0010012)1.78048683
116Abnormality of the 1st metacarpal (HP:0010009)1.77327530
117Fused cervical vertebrae (HP:0002949)1.76960596
118Hypoplasia of the pons (HP:0012110)1.76564876
119Microvesicular hepatic steatosis (HP:0001414)1.75588901
120Septo-optic dysplasia (HP:0100842)1.74510236
121Flat capital femoral epiphysis (HP:0003370)1.74338967
122Slender long bone (HP:0003100)1.73534609
123Morphological abnormality of the inner ear (HP:0011390)1.73438750
124Abnormal delivery (HP:0001787)1.73348259
125Neoplasm of the pancreas (HP:0002894)1.72979290
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72845811
127Small hand (HP:0200055)1.71739877
128Broad phalanges of the hand (HP:0009768)1.71416441
129Abnormality of the aortic arch (HP:0012303)1.71347732
130Breech presentation (HP:0001623)1.71223076
131Anal stenosis (HP:0002025)1.70221888
132Bone marrow hypocellularity (HP:0005528)1.70035552
133Self-mutilation (HP:0000742)1.68881326
134Acute encephalopathy (HP:0006846)1.68115318
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.67328092
136Neoplasm of the oral cavity (HP:0100649)1.66458025
137Duplication of thumb phalanx (HP:0009942)1.66439264
138Polycythemia (HP:0001901)1.65061143
139Increased hepatocellular lipid droplets (HP:0006565)1.65012011
140Homocystinuria (HP:0002156)1.63698014
141Abnormality of homocysteine metabolism (HP:0010919)1.63698014
142Choanal atresia (HP:0000453)1.63598501
143Hyperglycinemia (HP:0002154)1.63596259
144Atresia of the external auditory canal (HP:0000413)1.63588964
145Microtia (HP:0008551)1.62861081
146Preaxial hand polydactyly (HP:0001177)1.62792473
147Facial cleft (HP:0002006)1.62327883
148Abnormality of the pons (HP:0007361)1.61788613
149Abnormality of methionine metabolism (HP:0010901)1.61788115
150Oligodontia (HP:0000677)1.61577367
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61494690
152Rough bone trabeculation (HP:0100670)1.61494054
153Embryonal neoplasm (HP:0002898)1.61360710
154Abnormality of the astrocytes (HP:0100707)1.60531293
155Bifid tongue (HP:0010297)1.60481072
156High anterior hairline (HP:0009890)1.58819506
157Squamous cell carcinoma (HP:0002860)1.57467700
158Abnormality of subcutaneous fat tissue (HP:0001001)1.56672165
159Anophthalmia (HP:0000528)1.56444819
160Gastrointestinal atresia (HP:0002589)1.54948059
161Maternal diabetes (HP:0009800)1.54261505
162Short hallux (HP:0010109)1.54150917
163Aplasia/hypoplasia of the humerus (HP:0006507)1.53619416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.73148897
2LATS14.47588149
3CDC73.74879647
4STK38L3.53774259
5VRK23.49366247
6CDK123.11135578
7WEE12.91458655
8TSSK62.79368558
9BRSK22.74972421
10NEK22.71038455
11SRPK12.58201940
12STK32.41941289
13TAF12.26992013
14ACVR1B2.14932608
15PBK2.06410716
16EIF2AK32.04699009
17DYRK31.98564706
18ZAK1.93643567
19MKNK21.90010548
20MAP3K61.79249244
21PLK11.75340713
22TNIK1.69183414
23TTK1.67033018
24CDK41.59880087
25SMG11.58040578
26CHEK21.56882454
27EEF2K1.46535824
28PLK31.43317488
29TRIM281.41034094
30KSR21.39351963
31AURKB1.38916512
32MAP3K101.38294426
33WNK31.34096967
34TYRO31.32655553
35ERBB41.31865720
36BRSK11.31839980
37FRK1.31457029
38PRKD31.31418704
39DYRK21.29315593
40PNCK1.28413651
41PLK41.28229030
42CHEK11.27768055
43MST41.27061161
44NME11.26813563
45RAF11.26233032
46CDK91.22613555
47STK381.20113664
48CDK71.20022718
49EIF2AK21.14788391
50PASK1.14010015
51CAMK1D1.13733477
52CDK31.08776537
53STK161.08467190
54BUB11.07517018
55RPS6KA41.06863195
56NME21.04307758
57PAK61.04005031
58TRIB31.01321348
59BMPR1B0.99845457
60KSR10.98688129
61ABL20.97678644
62MELK0.96968017
63ATM0.96325287
64MKNK10.95045629
65MARK30.93147197
66CDK20.91195698
67ALK0.86824937
68DYRK1A0.85460789
69CDK60.85209469
70NLK0.84846523
71ATR0.82779577
72EPHA30.80906039
73JAK30.79371547
74BRD40.78719605
75MTOR0.75916284
76PRKAA20.75643516
77FGFR10.75510317
78MAPK100.73901420
79MAP3K80.72795856
80CDK10.70412379
81PLK20.70232406
82DMPK0.69447541
83PRKAA10.68768351
84CSNK1G10.67188805
85TAOK10.65705569
86DDR20.65275215
87PDGFRB0.62547339
88PRKDC0.62244599
89MAP3K50.60933433
90GRK10.60847904
91CAMK1G0.60618368
92MUSK0.59823537
93PAK20.56012800
94CDK80.54643782
95PDGFRA0.53850445
96TGFBR10.53285800
97EIF2AK10.52856962
98PKN20.52591529
99CSNK2A10.52202790
100AURKA0.51162478
101CSNK2A20.49856239
102VRK10.49129926
103CSNK1G30.47009086
104SGK20.46993735
105WNK40.46499878
106CLK10.45848389
107MAP3K40.45690978
108MAP3K90.45461711
109CSNK1A1L0.44702036
110HIPK20.44677303
111STK390.43819227
112RPS6KB20.43160151
113MAPK140.42920697
114STK240.42873717
115MAPKAPK50.42180534
116STK40.41248114
117NEK10.39423147
118ABL10.38359162
119FGFR30.37405189
120DAPK10.36961659
121MET0.36956359
122GSK3B0.36760442
123CSNK1E0.36648842
124PRKCI0.36056498
125MAPK110.35812154
126CSNK1G20.34495325
127CSNK1D0.33433834
128PAK40.33112996
129BRAF0.33073927
130MAP2K30.32543171
131SGK30.32358921
132TAOK30.31769899
133NUAK10.31759188
134MAPK10.30979746
135PAK10.30600249
136STK100.30318843
137MAP2K40.30152934
138PIM10.29491225
139FGFR20.26628841
140ERBB20.25526899
141JAK20.25130662

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75248506
2Cell cycle_Homo sapiens_hsa041103.72115257
3RNA polymerase_Homo sapiens_hsa030203.31938798
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06314364
5RNA transport_Homo sapiens_hsa030132.99212514
6Vitamin B6 metabolism_Homo sapiens_hsa007502.70351194
7Basal transcription factors_Homo sapiens_hsa030222.59211605
8Proteasome_Homo sapiens_hsa030502.58528430
9Fanconi anemia pathway_Homo sapiens_hsa034602.51799272
10Pentose phosphate pathway_Homo sapiens_hsa000302.43081661
11mRNA surveillance pathway_Homo sapiens_hsa030152.26481311
12p53 signaling pathway_Homo sapiens_hsa041151.97853427
13Oocyte meiosis_Homo sapiens_hsa041141.89187948
14Homologous recombination_Homo sapiens_hsa034401.86662027
15RNA degradation_Homo sapiens_hsa030181.82062955
16Protein export_Homo sapiens_hsa030601.81723937
17Ribosome_Homo sapiens_hsa030101.80312907
18Spliceosome_Homo sapiens_hsa030401.74313427
19TGF-beta signaling pathway_Homo sapiens_hsa043501.71321612
20Circadian rhythm_Homo sapiens_hsa047101.70820207
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70318964
22MicroRNAs in cancer_Homo sapiens_hsa052061.68655279
23One carbon pool by folate_Homo sapiens_hsa006701.67435534
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48837444
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46190530
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44000739
27Biosynthesis of amino acids_Homo sapiens_hsa012301.36492841
28Pancreatic cancer_Homo sapiens_hsa052121.30004436
29Herpes simplex infection_Homo sapiens_hsa051681.28477848
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.28332989
31DNA replication_Homo sapiens_hsa030301.27955924
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27764946
33Steroid biosynthesis_Homo sapiens_hsa001001.23595157
34mTOR signaling pathway_Homo sapiens_hsa041501.22036594
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19295734
36Pyrimidine metabolism_Homo sapiens_hsa002401.12432302
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11509937
38Nucleotide excision repair_Homo sapiens_hsa034201.09111547
39Small cell lung cancer_Homo sapiens_hsa052221.08927737
40Prostate cancer_Homo sapiens_hsa052151.06740125
41Lysine degradation_Homo sapiens_hsa003101.06355995
42Adherens junction_Homo sapiens_hsa045201.05398416
43Mismatch repair_Homo sapiens_hsa034301.04996638
44Pyruvate metabolism_Homo sapiens_hsa006201.04544230
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03351095
46Propanoate metabolism_Homo sapiens_hsa006401.00543144
47Hepatitis B_Homo sapiens_hsa051611.00170218
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96189559
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94680942
50Epstein-Barr virus infection_Homo sapiens_hsa051690.92809040
51FoxO signaling pathway_Homo sapiens_hsa040680.92774461
52Thyroid cancer_Homo sapiens_hsa052160.91139091
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91123941
54Chronic myeloid leukemia_Homo sapiens_hsa052200.90976338
55Prolactin signaling pathway_Homo sapiens_hsa049170.90326259
56Choline metabolism in cancer_Homo sapiens_hsa052310.88774255
57Viral carcinogenesis_Homo sapiens_hsa052030.88530263
58Colorectal cancer_Homo sapiens_hsa052100.87879065
59Renal cell carcinoma_Homo sapiens_hsa052110.86903584
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86086580
61Purine metabolism_Homo sapiens_hsa002300.83848890
62Dorso-ventral axis formation_Homo sapiens_hsa043200.81406815
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80278590
64Nitrogen metabolism_Homo sapiens_hsa009100.78440504
65Endometrial cancer_Homo sapiens_hsa052130.73990018
66HTLV-I infection_Homo sapiens_hsa051660.71834959
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.71190263
68Insulin resistance_Homo sapiens_hsa049310.70094111
69Carbon metabolism_Homo sapiens_hsa012000.69378297
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69276140
71Hippo signaling pathway_Homo sapiens_hsa043900.68409892
72Arginine biosynthesis_Homo sapiens_hsa002200.68314771
73Huntingtons disease_Homo sapiens_hsa050160.68065119
74Glucagon signaling pathway_Homo sapiens_hsa049220.67948151
75Hedgehog signaling pathway_Homo sapiens_hsa043400.67730644
76AMPK signaling pathway_Homo sapiens_hsa041520.65313818
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.63110472
78Non-small cell lung cancer_Homo sapiens_hsa052230.61398119
79Inositol phosphate metabolism_Homo sapiens_hsa005620.59991513
80Base excision repair_Homo sapiens_hsa034100.59854110
81Parkinsons disease_Homo sapiens_hsa050120.59675938
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59408746
83Glioma_Homo sapiens_hsa052140.58638796
84Influenza A_Homo sapiens_hsa051640.56466657
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54180525
86Folate biosynthesis_Homo sapiens_hsa007900.53249072
87GnRH signaling pathway_Homo sapiens_hsa049120.51761006
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51747315
89Fatty acid elongation_Homo sapiens_hsa000620.51178527
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50854203
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50487336
92Wnt signaling pathway_Homo sapiens_hsa043100.49803277
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49714592
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49627764
95Sulfur metabolism_Homo sapiens_hsa009200.48835793
96Basal cell carcinoma_Homo sapiens_hsa052170.48227909
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48176274
98Estrogen signaling pathway_Homo sapiens_hsa049150.47467350
99Pathways in cancer_Homo sapiens_hsa052000.47156854
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46754306
101Oxidative phosphorylation_Homo sapiens_hsa001900.46250698
102MAPK signaling pathway_Homo sapiens_hsa040100.45812792
103Metabolic pathways_Homo sapiens_hsa011000.44818529
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.44585652
105N-Glycan biosynthesis_Homo sapiens_hsa005100.44115840
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43657428
107Long-term potentiation_Homo sapiens_hsa047200.43173408
108Glutathione metabolism_Homo sapiens_hsa004800.41578558
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40742365
110Melanoma_Homo sapiens_hsa052180.40590663
111ErbB signaling pathway_Homo sapiens_hsa040120.40054159
112Sulfur relay system_Homo sapiens_hsa041220.39538610
113Vitamin digestion and absorption_Homo sapiens_hsa049770.38725253
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38675339
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.38554655
116Proteoglycans in cancer_Homo sapiens_hsa052050.38190318
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.37750081
118Amphetamine addiction_Homo sapiens_hsa050310.36631222
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36405833
120Non-homologous end-joining_Homo sapiens_hsa034500.36287252
121Fatty acid metabolism_Homo sapiens_hsa012120.35995837
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.35575533
123Shigellosis_Homo sapiens_hsa051310.35076908
124Bladder cancer_Homo sapiens_hsa052190.35010839
125cAMP signaling pathway_Homo sapiens_hsa040240.34419051
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34225477
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.32977173
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.32736138
129Measles_Homo sapiens_hsa051620.32699410
130TNF signaling pathway_Homo sapiens_hsa046680.32262257
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31723045
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31342041
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.30945188
134Selenocompound metabolism_Homo sapiens_hsa004500.30941217
135T cell receptor signaling pathway_Homo sapiens_hsa046600.30507671
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30245024
137Tight junction_Homo sapiens_hsa045300.29435500
138Arginine and proline metabolism_Homo sapiens_hsa003300.28421622
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.22237924
140Alzheimers disease_Homo sapiens_hsa050100.20819621
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18884945
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18859872
143Phototransduction_Homo sapiens_hsa047440.18356272
144Fatty acid biosynthesis_Homo sapiens_hsa000610.15697236
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14227198
146Ether lipid metabolism_Homo sapiens_hsa005650.07456500
147Melanogenesis_Homo sapiens_hsa049160.07420073
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06683362
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06547849
150Fat digestion and absorption_Homo sapiens_hsa049750.06006399

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