DHX34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)8.70200088
2intestinal cholesterol absorption (GO:0030299)7.24722353
3protein retention in ER lumen (GO:0006621)6.37532948
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.09219808
5digestion (GO:0007586)5.69110764
6positive regulation by symbiont of host defense response (GO:0052509)5.47286135
7modulation by symbiont of host defense response (GO:0052031)5.47286135
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.47286135
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.47286135
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.47286135
11modulation by symbiont of host immune response (GO:0052553)5.47286135
12negative regulation of cell killing (GO:0031342)5.22739873
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22739873
14response to peptidoglycan (GO:0032494)5.04259263
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91973722
16macrophage activation involved in immune response (GO:0002281)4.48958973
17proline biosynthetic process (GO:0006561)4.43456965
18detection of other organism (GO:0098543)4.43447978
19neutrophil activation involved in immune response (GO:0002283)4.33017543
20valine metabolic process (GO:0006573)4.23677896
21detection of bacterium (GO:0016045)4.22618175
22detection of molecule of bacterial origin (GO:0032490)4.21633274
23detection of external biotic stimulus (GO:0098581)4.01886001
24negative regulation of interleukin-12 production (GO:0032695)3.98288740
25regulation of interferon-beta biosynthetic process (GO:0045357)3.96919257
26Golgi transport vesicle coating (GO:0048200)3.83772990
27COPI coating of Golgi vesicle (GO:0048205)3.83772990
28cobalamin metabolic process (GO:0009235)3.77985978
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.77827417
30positive regulation of gamma-delta T cell activation (GO:0046645)3.76905647
31peptidyl-proline hydroxylation (GO:0019511)3.76820916
32regulation of gamma-delta T cell differentiation (GO:0045586)3.74817219
33positive regulation of nuclease activity (GO:0032075)3.74221826
34activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.74111569
35folic acid-containing compound biosynthetic process (GO:0009396)3.66814042
36respiratory burst (GO:0045730)3.65828534
37cellular extravasation (GO:0045123)3.63428142
38response to host immune response (GO:0052572)3.58915104
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58915104
40serine family amino acid biosynthetic process (GO:0009070)3.58566084
41detection of biotic stimulus (GO:0009595)3.54745742
42response to muramyl dipeptide (GO:0032495)3.50731879
43regulation of nuclease activity (GO:0032069)3.46912063
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44972711
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44972711
46response to host (GO:0075136)3.43907045
47response to host defenses (GO:0052200)3.43907045
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43907045
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43455522
50regulation of B cell receptor signaling pathway (GO:0050855)3.43340203
51germinal center formation (GO:0002467)3.42300657
52neutrophil activation (GO:0042119)3.38458030
53viral transcription (GO:0019083)3.36916925
54positive regulation of Cdc42 GTPase activity (GO:0043089)3.36433513
55leukocyte migration involved in inflammatory response (GO:0002523)3.34241584
56cysteine metabolic process (GO:0006534)3.33841010
57endoplasmic reticulum unfolded protein response (GO:0030968)3.33614872
58regulation of gamma-delta T cell activation (GO:0046643)3.33482405
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31966388
60regulation of mast cell degranulation (GO:0043304)3.31473425
61regulation of T-helper 2 cell differentiation (GO:0045628)3.29998563
62glycine metabolic process (GO:0006544)3.29220600
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.29198979
64translational termination (GO:0006415)3.28977425
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28232076
66regulation of leukocyte degranulation (GO:0043300)3.27109315
67intestinal absorption (GO:0050892)3.26342056
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24918300
69cellular response to unfolded protein (GO:0034620)3.24046241
70response to interleukin-15 (GO:0070672)3.22184919
71granulocyte activation (GO:0036230)3.21299381
724-hydroxyproline metabolic process (GO:0019471)3.21146856
73protein hydroxylation (GO:0018126)3.20212277
74formation of translation preinitiation complex (GO:0001731)3.19654868
75pentose-phosphate shunt (GO:0006098)3.17661047
76NIK/NF-kappaB signaling (GO:0038061)3.16447143
77macrophage activation (GO:0042116)3.15712877
78regulation of translational fidelity (GO:0006450)3.15505814
79ribosomal small subunit assembly (GO:0000028)3.15334424
80negative regulation of leukocyte mediated immunity (GO:0002704)3.14878251
81sterol catabolic process (GO:0016127)3.14009223
82cholesterol catabolic process (GO:0006707)3.14009223
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13009431
84negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12396097
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10630203
86L-alpha-amino acid transmembrane transport (GO:1902475)3.10042876
87cellular response to topologically incorrect protein (GO:0035967)3.09449417
88production of molecular mediator involved in inflammatory response (GO:0002532)3.08708753
89antigen processing and presentation of endogenous antigen (GO:0019883)3.07386852
90immunoglobulin mediated immune response (GO:0016064)3.06920810
91translational elongation (GO:0006414)3.06222418
92L-serine metabolic process (GO:0006563)3.05566706
93DNA unwinding involved in DNA replication (GO:0006268)3.04636077
94protein targeting to ER (GO:0045047)3.03298981
95myeloid cell activation involved in immune response (GO:0002275)3.01533588
96proline metabolic process (GO:0006560)3.01305669
97transcytosis (GO:0045056)3.00233904
98ER-nucleus signaling pathway (GO:0006984)2.98161484
99cotranslational protein targeting to membrane (GO:0006613)2.96995371
100regulation of mast cell activation involved in immune response (GO:0033006)2.95735698
101positive regulation of histone deacetylation (GO:0031065)2.92532360
102cellular response to type I interferon (GO:0071357)2.91570522
103type I interferon signaling pathway (GO:0060337)2.91570522
104response to type I interferon (GO:0034340)2.91335221
105negative regulation of erythrocyte differentiation (GO:0045647)2.91169625
106neutrophil mediated immunity (GO:0002446)2.89817866
107response to endoplasmic reticulum stress (GO:0034976)2.89351042
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89107470
109maternal placenta development (GO:0001893)2.87857523
110negative regulation of toll-like receptor signaling pathway (GO:0034122)2.87351538
111DNA deamination (GO:0045006)2.86434998
112negative regulation of phagocytosis (GO:0050765)2.85736980
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82932669
114retinoic acid receptor signaling pathway (GO:0048384)2.82806160
115antigen processing and presentation via MHC class Ib (GO:0002475)2.82590914
116translesion synthesis (GO:0019985)2.79595135
117mitotic G1 DNA damage checkpoint (GO:0031571)2.78656288
118protein localization to endoplasmic reticulum (GO:0070972)2.77660097
119apoptotic process involved in morphogenesis (GO:0060561)2.76968360
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76111228
121tetrahydrofolate metabolic process (GO:0046653)2.76023505
122serine family amino acid metabolic process (GO:0009069)2.75524204
123mannose metabolic process (GO:0006013)2.74922187
124translational initiation (GO:0006413)2.74390701
125positive thymic T cell selection (GO:0045059)2.73689369
126regulation of necroptotic process (GO:0060544)2.72815340
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72705427
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71935282
129B cell receptor signaling pathway (GO:0050853)2.71231176
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71049926
131regulation of regulated secretory pathway (GO:1903305)2.68107228
132cellular response to interleukin-15 (GO:0071350)2.67239759
133negative regulation of digestive system process (GO:0060457)2.65642844
134leukotriene biosynthetic process (GO:0019370)2.64406451
135pteridine-containing compound biosynthetic process (GO:0042559)2.63983087
136positive regulation of interferon-alpha production (GO:0032727)2.63585301
137modulation by virus of host process (GO:0019054)2.63494368
138cellular modified amino acid catabolic process (GO:0042219)2.63309191
139negative regulation of T cell mediated immunity (GO:0002710)2.62954752
1403-UTR-mediated mRNA stabilization (GO:0070935)2.62531106
141negative regulation of cell size (GO:0045792)2.62107561
142modulation by symbiont of host cellular process (GO:0044068)2.61267007
143negative regulation of cytokine production involved in immune response (GO:0002719)2.60102726
144defense response to protozoan (GO:0042832)2.59680020
145protein localization to endosome (GO:0036010)2.58395566
146NADPH regeneration (GO:0006740)2.57651767
147thymic T cell selection (GO:0045061)2.57636352
148microglial cell activation (GO:0001774)2.57582984
149response to laminar fluid shear stress (GO:0034616)2.56556553
150negative regulation of interleukin-6 production (GO:0032715)2.56141133
151negative regulation of type 2 immune response (GO:0002829)2.56132159
152one-carbon metabolic process (GO:0006730)2.55417552
153negative regulation of innate immune response (GO:0045824)2.54201574
154intracellular estrogen receptor signaling pathway (GO:0030520)2.53363740
155homocysteine metabolic process (GO:0050667)2.52190467
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50816750
157DNA strand elongation involved in DNA replication (GO:0006271)2.50314428
158viral life cycle (GO:0019058)2.50278876
159regulation of T cell tolerance induction (GO:0002664)2.49925596
160leukocyte degranulation (GO:0043299)2.49692895
161positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49673478
162IMP biosynthetic process (GO:0006188)2.48679576
163regulation of chromatin binding (GO:0035561)2.48161153
164aspartate family amino acid catabolic process (GO:0009068)2.45036944
165B cell mediated immunity (GO:0019724)2.44432855
166positive regulation of cellular amide metabolic process (GO:0034250)2.44219099
167response to unfolded protein (GO:0006986)2.43622076
168regulation of mast cell activation (GO:0033003)2.42933977
169protein maturation by protein folding (GO:0022417)2.42011054
170ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.41709252
171cellular protein complex disassembly (GO:0043624)2.38546460
172protein complex disassembly (GO:0043241)2.37674767
173maintenance of protein localization in organelle (GO:0072595)2.37615382
174regulation of phospholipase A2 activity (GO:0032429)2.36971142
175mitochondrial calcium ion transport (GO:0006851)2.35669156
176response to topologically incorrect protein (GO:0035966)2.34434340
177regulation of translation in response to stress (GO:0043555)2.33096107
178DNA strand elongation (GO:0022616)2.32596408
179mitotic G1/S transition checkpoint (GO:0044819)2.32536931
180branched-chain amino acid metabolic process (GO:0009081)2.32165035
181leukocyte aggregation (GO:0070486)2.30900827
182cellular hyperosmotic response (GO:0071474)2.29346491
183glycolipid catabolic process (GO:0019377)2.28999818
184tricarboxylic acid metabolic process (GO:0072350)2.28548107
185regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.28325206
186DNA geometric change (GO:0032392)2.27229375
187DNA duplex unwinding (GO:0032508)2.26653491
188negative regulation of RNA splicing (GO:0033119)2.26503541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.54628913
2MYC_22102868_ChIP-Seq_BL_Human3.26169590
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99971509
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.51572283
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.48303575
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.41778476
7VDR_21846776_ChIP-Seq_THP-1_Human2.35103477
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.35055442
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27133424
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22767353
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09528730
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.02305998
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91632056
14MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87280287
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.85695291
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85120477
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83661603
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77155426
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.72233148
20CIITA_25753668_ChIP-Seq_RAJI_Human1.72135272
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.72093696
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70162475
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68362140
24SPI1_23127762_ChIP-Seq_K562_Human1.67756075
25UTX_26944678_Chip-Seq_JUKART_Human1.64361723
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64086236
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64037651
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59722589
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57449866
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55449864
31MAF_26560356_Chip-Seq_TH1_Human1.53657239
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53343469
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53246203
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.52785764
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.49284299
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48757093
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48744969
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47422013
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46675354
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45582841
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45513395
42KDM2B_26808549_Chip-Seq_DND41_Human1.45138231
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45054963
44KDM2B_26808549_Chip-Seq_K562_Human1.44832669
45SCL_19346495_ChIP-Seq_HPC-7_Human1.44013401
46LXR_22292898_ChIP-Seq_THP-1_Human1.43611253
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43208562
48XRN2_22483619_ChIP-Seq_HELA_Human1.42898111
49* IRF8_27001747_Chip-Seq_BMDM_Mouse1.42477411
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40973055
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40918645
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40066789
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.38030680
54MAF_26560356_Chip-Seq_TH2_Human1.34975918
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34495728
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32050189
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31327081
58VDR_24763502_ChIP-Seq_THP-1_Human1.29420582
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28777625
60MYB_26560356_Chip-Seq_TH1_Human1.28337815
61KDM5A_27292631_Chip-Seq_BREAST_Human1.27907048
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26690005
63MYB_26560356_Chip-Seq_TH2_Human1.26285902
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.26181841
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26167930
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26099701
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25814835
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25780073
69P68_20966046_ChIP-Seq_HELA_Human1.25735161
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.25594482
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25305039
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.23951477
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23663557
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23399565
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22960151
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22318512
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22182308
78SMC4_20622854_ChIP-Seq_HELA_Human1.22177250
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.22012341
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21184707
81GATA1_22025678_ChIP-Seq_K562_Human1.20298836
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20249492
83BCL6_27268052_Chip-Seq_Bcells_Human1.20165160
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19880204
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19037276
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18465993
87* GABP_19822575_ChIP-Seq_HepG2_Human1.17267585
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16150455
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15713378
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14754177
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12770765
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12758442
93* SPI1_23547873_ChIP-Seq_NB4_Human1.12121027
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11176980
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10564105
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.10260136
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10137609
98FOXP3_21729870_ChIP-Seq_TREG_Human1.09989517
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09444649
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08176060
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08125109
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07498326
103CREB1_26743006_Chip-Seq_LNCaP_Human1.07320203
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.06539400
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06525771
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06299564
107DCP1A_22483619_ChIP-Seq_HELA_Human1.06297960
108BCOR_27268052_Chip-Seq_Bcells_Human1.06077277
109NCOR1_26117541_ChIP-Seq_K562_Human1.06062767
110RACK7_27058665_Chip-Seq_MCF-7_Human1.05710758
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05200302
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05041262
113NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04840269
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04171881
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03995282
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03930591
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03507603
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02702575
119ATF3_27146783_Chip-Seq_COLON_Human1.02213911
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.01840808
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01236634
122TFEB_21752829_ChIP-Seq_HELA_Human0.99844302
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99630773
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98534780
125PHF8_20622854_ChIP-Seq_HELA_Human0.98220876
126VDR_23849224_ChIP-Seq_CD4+_Human0.97633484
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97456486
128GATA6_25053715_ChIP-Seq_YYC3_Human0.97428601
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97048028
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96807879
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95435537
132CTCF_21964334_Chip-Seq_Bcells_Human0.94633594
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94558228
134ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93904319
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93203300
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92679300
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91871250
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91546400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.18334046
2MP0001666_abnormal_nutrient_absorption4.65930915
3MP0005220_abnormal_exocrine_pancreas4.22026951
4MP0005365_abnormal_bile_salt3.75154432
5MP0003724_increased_susceptibility_to3.30305439
6MP0008260_abnormal_autophagy2.86091857
7MP0002419_abnormal_innate_immunity2.60466597
8MP0003705_abnormal_hypodermis_morpholog2.45003799
9MP0003868_abnormal_feces_composition2.34288055
10MP0001873_stomach_inflammation2.02269516
11MP0003693_abnormal_embryo_hatching2.00692614
12MP0009278_abnormal_bone_marrow1.96723588
13MP0009785_altered_susceptibility_to1.93540300
14MP0003763_abnormal_thymus_physiology1.90868086
15MP0005085_abnormal_gallbladder_physiolo1.84355182
16MP0001533_abnormal_skeleton_physiology1.79213230
17MP0004381_abnormal_hair_follicle1.77093714
18MP0002693_abnormal_pancreas_physiology1.74515848
19MP0002132_abnormal_respiratory_system1.73285988
20MP0005084_abnormal_gallbladder_morpholo1.70006950
21MP0002396_abnormal_hematopoietic_system1.68823083
22MP0006082_CNS_inflammation1.67726642
23MP0000685_abnormal_immune_system1.66709989
24MP0000490_abnormal_crypts_of1.60517693
25MP0003300_gastrointestinal_ulcer1.60115938
26MP0004858_abnormal_nervous_system1.57829942
27MP0002148_abnormal_hypersensitivity_rea1.55802909
28MP0003077_abnormal_cell_cycle1.53948075
29MP0004808_abnormal_hematopoietic_stem1.53188579
30MP0001849_ear_inflammation1.51718355
31MP0008961_abnormal_basal_metabolism1.51005214
32MP0003453_abnormal_keratinocyte_physiol1.49071122
33MP0004510_myositis1.47552552
34MP0003959_abnormal_lean_body1.45585829
35MP0004957_abnormal_blastocyst_morpholog1.45214358
36MP0001800_abnormal_humoral_immune1.43918231
37MP0003111_abnormal_nucleus_morphology1.41208957
38MP0005076_abnormal_cell_differentiation1.41168852
39MP0003828_pulmonary_edema1.40570996
40MP0009333_abnormal_splenocyte_physiolog1.39873328
41MP0003303_peritoneal_inflammation1.38319771
42MP0010352_gastrointestinal_tract_polyps1.35754947
43MP0000689_abnormal_spleen_morphology1.35668102
44MP0002398_abnormal_bone_marrow1.35577984
45MP0001944_abnormal_pancreas_morphology1.33096944
46MP0003436_decreased_susceptibility_to1.32104949
47MP0010094_abnormal_chromosome_stability1.30061744
48MP0005670_abnormal_white_adipose1.28920523
49MP0000703_abnormal_thymus_morphology1.28547682
50MP0009840_abnormal_foam_cell1.26923508
51MP0004264_abnormal_extraembryonic_tissu1.26838972
52MP0002405_respiratory_system_inflammati1.25763232
53MP0002139_abnormal_hepatobiliary_system1.25217188
54MP0005058_abnormal_lysosome_morphology1.24799368
55MP0005310_abnormal_salivary_gland1.23563832
56MP0002722_abnormal_immune_system1.22119696
57MP0002998_abnormal_bone_remodeling1.21205934
58MP0005397_hematopoietic_system_phenotyp1.20023935
59MP0001545_abnormal_hematopoietic_system1.20023935
60MP0001790_abnormal_immune_system1.19742579
61MP0005387_immune_system_phenotype1.19742579
62MP0002877_abnormal_melanocyte_morpholog1.15385496
63MP0002452_abnormal_antigen_presenting1.13739279
64MP0005451_abnormal_body_composition1.13462237
65MP0001845_abnormal_inflammatory_respons1.12530333
66MP0003866_abnormal_defecation1.12448529
67MP0003075_altered_response_to1.12394047
68MP0002723_abnormal_immune_serum1.11163632
69MP0002420_abnormal_adaptive_immunity1.10384651
70MP0005360_urolithiasis1.07220147
71MP0000716_abnormal_immune_system1.06744626
72MP0001819_abnormal_immune_cell1.06640653
73MP0003183_abnormal_peptide_metabolism1.05952495
74MP0000678_abnormal_parathyroid_gland1.05840659
75MP0002429_abnormal_blood_cell1.04875944
76MP0000598_abnormal_liver_morphology1.00695407
77MP0003091_abnormal_cell_migration0.99357153
78MP0000609_abnormal_liver_physiology0.99305002
79MP0009764_decreased_sensitivity_to0.99112180
80MP0002277_abnormal_respiratory_mucosa0.98933617
81MP0003448_altered_tumor_morphology0.98795560
82MP0010155_abnormal_intestine_physiology0.98675975
83MP0002138_abnormal_hepatobiliary_system0.98305273
84MP0004233_abnormal_muscle_weight0.97575028
85MP0001835_abnormal_antigen_presentation0.96587378
86MP0003123_paternal_imprinting0.94544721
87MP0006054_spinal_hemorrhage0.94491483
88MP0000858_altered_metastatic_potential0.94295948
89MP0001730_embryonic_growth_arrest0.92353694
90MP0000350_abnormal_cell_proliferation0.92255512
91MP0004185_abnormal_adipocyte_glucose0.91706371
92MP0002019_abnormal_tumor_incidence0.91555056
93MP0004947_skin_inflammation0.90597323
94MP0003172_abnormal_lysosome_physiology0.90458268
95MP0003191_abnormal_cellular_cholesterol0.89208655
96MP0003252_abnormal_bile_duct0.87623126
97MP0009643_abnormal_urine_homeostasis0.87448534
98MP0003283_abnormal_digestive_organ0.86720000
99MP0005000_abnormal_immune_tolerance0.86349997
100MP0001851_eye_inflammation0.86317462
101MP0002166_altered_tumor_susceptibility0.85994444
102MP0001853_heart_inflammation0.84543532
103MP0005390_skeleton_phenotype0.84508553
104MP0009672_abnormal_birth_weight0.84363529
105MP0005671_abnormal_response_to0.84226411
106MP0000465_gastrointestinal_hemorrhage0.83374201
107MP0003806_abnormal_nucleotide_metabolis0.83373887
108MP0002254_reproductive_system_inflammat0.82724986
109MP0000003_abnormal_adipose_tissue0.82264843
110MP0002080_prenatal_lethality0.81874805
111MP0002118_abnormal_lipid_homeostasis0.81812667
112MP0005621_abnormal_cell_physiology0.81595943
113MP0005409_darkened_coat_color0.81458121
114MP0005375_adipose_tissue_phenotype0.81286634
115MP0003566_abnormal_cell_adhesion0.81170420
116MP0004197_abnormal_fetal_growth/weight/0.80405761
117MP0003656_abnormal_erythrocyte_physiolo0.80387778
118MP0005025_abnormal_response_to0.80190485
119MP0002796_impaired_skin_barrier0.80013126
120MP0000313_abnormal_cell_death0.79579411
121MP0003221_abnormal_cardiomyocyte_apopto0.78900750
122MP0008469_abnormal_protein_level0.78233318
123MP0005464_abnormal_platelet_physiology0.76768977
124MP0004883_abnormal_blood_vessel0.76168842
125MP0003638_abnormal_response/metabolism_0.75756818
126MP0010307_abnormal_tumor_latency0.75137322
127MP0005666_abnormal_adipose_tissue0.74656039
128MP0001697_abnormal_embryo_size0.74235528
129MP0002088_abnormal_embryonic_growth/wei0.73737904
130MP0010329_abnormal_lipoprotein_level0.73480874
131MP0005023_abnormal_wound_healing0.72966494
132MP0001672_abnormal_embryogenesis/_devel0.72090186
133MP0005380_embryogenesis_phenotype0.72090186
134MP0002928_abnormal_bile_duct0.71969483
135MP0010234_abnormal_vibrissa_follicle0.71931497
136MP0001348_abnormal_lacrimal_gland0.71846533
137MP0009931_abnormal_skin_appearance0.71795024
138MP0003045_fibrosis0.68663957
139MP0005166_decreased_susceptibility_to0.68241306
140MP0000343_altered_response_to0.68005713
141MP0005164_abnormal_response_to0.67671755
142MP0001915_intracranial_hemorrhage0.67556101

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.64932534
2Recurrent abscess formation (HP:0002722)4.76854379
3Recurrent bacterial skin infections (HP:0005406)4.59884142
4Abnormality of macrophages (HP:0004311)4.41800043
5Myositis (HP:0100614)4.31835969
6Orchitis (HP:0100796)4.12292362
7Decreased subcutaneous fat (HP:0001002)3.91007520
8Abnormality of subcutaneous fat tissue (HP:0001001)3.81729839
9Recurrent gram-negative bacterial infections (HP:0005420)3.81037719
10Obstructive lung disease (HP:0006536)3.67829608
11Chronic obstructive pulmonary disease (HP:0006510)3.67829608
12Retrobulbar optic neuritis (HP:0100654)3.46833085
13Optic neuritis (HP:0100653)3.46833085
14Gastrointestinal infarctions (HP:0005244)3.42633874
15Mediastinal lymphadenopathy (HP:0100721)3.41499851
16Gingivitis (HP:0000230)3.29261066
17Increased IgE level (HP:0003212)3.18632107
18Steatorrhea (HP:0002570)3.13721312
19Elevated erythrocyte sedimentation rate (HP:0003565)3.08353493
20Stomatitis (HP:0010280)3.06388248
21Nasal polyposis (HP:0100582)2.96819104
22Meningitis (HP:0001287)2.90163940
23IgM deficiency (HP:0002850)2.88142115
24Fat malabsorption (HP:0002630)2.87354849
25Hypochromic anemia (HP:0001931)2.86995615
26Fatigue (HP:0012378)2.85815281
27Recurrent bronchitis (HP:0002837)2.83579838
28Abnormality of the nasal mucosa (HP:0000433)2.80192955
29Abnormality of the thoracic spine (HP:0100711)2.79756878
30Type I diabetes mellitus (HP:0100651)2.77847472
31Recurrent skin infections (HP:0001581)2.77058022
32Progressive muscle weakness (HP:0003323)2.76649734
33Thoracic kyphosis (HP:0002942)2.75377404
34Abnormality of endocrine pancreas physiology (HP:0012093)2.70795918
35Abnormality of the pancreatic islet cells (HP:0006476)2.70795918
36Hypochromic microcytic anemia (HP:0004840)2.70306479
37Gastrointestinal inflammation (HP:0004386)2.68586172
38Urticaria (HP:0001025)2.65397368
39Short chin (HP:0000331)2.64951392
40Carpal bone hypoplasia (HP:0001498)2.63602898
41Broad face (HP:0000283)2.62889611
42Keratoconjunctivitis sicca (HP:0001097)2.57811163
43Late onset (HP:0003584)2.54066719
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53188074
45Metaphyseal cupping (HP:0003021)2.50324653
46Gout (HP:0001997)2.48831550
47Multiple enchondromatosis (HP:0005701)2.40866718
48Inflammation of the large intestine (HP:0002037)2.40293981
49T lymphocytopenia (HP:0005403)2.39674940
50Joint stiffness (HP:0001387)2.38728874
51Encephalitis (HP:0002383)2.38440970
52Slow saccadic eye movements (HP:0000514)2.37759263
53Chest pain (HP:0100749)2.36774332
54Exocrine pancreatic insufficiency (HP:0001738)2.36150285
55Prolonged bleeding time (HP:0003010)2.34660556
56Abnormality of T cells (HP:0002843)2.33111653
57Abnormality of cells of the erythroid lineage (HP:0012130)2.32728674
58Flat acetabular roof (HP:0003180)2.32194361
59Increased connective tissue (HP:0009025)2.28757242
60Recurrent cutaneous fungal infections (HP:0011370)2.27152028
61Chronic mucocutaneous candidiasis (HP:0002728)2.27152028
62Peritonitis (HP:0002586)2.27008942
63Basal cell carcinoma (HP:0002671)2.26078758
64Abnormality of T cell physiology (HP:0011840)2.26032565
65Segmental peripheral demyelination/remyelination (HP:0003481)2.26007224
66Increased serum ferritin (HP:0003281)2.25872925
67Vasculitis (HP:0002633)2.25050259
68Loss of speech (HP:0002371)2.24211345
69Dysostosis multiplex (HP:0000943)2.22553266
70Ketosis (HP:0001946)2.21201024
71Hyperacusis (HP:0010780)2.20478011
72Keratoconjunctivitis (HP:0001096)2.20006479
73Recurrent viral infections (HP:0004429)2.18611013
74Abnormality of the intrinsic pathway (HP:0010989)2.18498817
75Abnormal number of erythroid precursors (HP:0012131)2.17801377
76Abnormality of T cell number (HP:0011839)2.16921895
77Thrombocytosis (HP:0001894)2.16776106
78Cerebral aneurysm (HP:0004944)2.16564993
79Hypoplasia of the pons (HP:0012110)2.15018420
80Maternal diabetes (HP:0009800)2.13013482
81Myocardial infarction (HP:0001658)2.11655802
82Anorexia (HP:0002039)2.11142995
83Episodic fever (HP:0001954)2.10376036
84Mucopolysacchariduria (HP:0008155)2.09184332
85Urinary glycosaminoglycan excretion (HP:0003541)2.09184332
86Arterial thrombosis (HP:0004420)2.08197817
87Hepatosplenomegaly (HP:0001433)2.07197533
88Hypoproteinemia (HP:0003075)2.06027910
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.06007052
90Hemorrhage of the eye (HP:0011885)2.05310054
91Abnormality of the fingertips (HP:0001211)2.04568949
92Obstructive sleep apnea (HP:0002870)2.03426182
93Ependymoma (HP:0002888)2.03258591
94Periodontitis (HP:0000704)2.02727042
95Abnormality of the peritoneum (HP:0002585)2.02696764
96Long palpebral fissure (HP:0000637)2.01979350
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.01466954
98Osteomyelitis (HP:0002754)2.01119378
99Premature skin wrinkling (HP:0100678)2.01051604
100Verrucae (HP:0200043)2.00833725
101Papilloma (HP:0012740)2.00833725
102Hypertensive crisis (HP:0100735)2.00463607
103Amyloidosis (HP:0011034)1.99344773
104Subacute progressive viral hepatitis (HP:0006572)1.98418750
105Epistaxis (HP:0000421)1.98058904
106Cortical dysplasia (HP:0002539)1.97409770
107Colitis (HP:0002583)1.96786809
108Reticulocytopenia (HP:0001896)1.95957188
109Deformed sella turcica (HP:0002681)1.95725307
110Abnormality of cells of the lymphoid lineage (HP:0012140)1.93692364
111Severe short stature (HP:0003510)1.93270528
112Hand muscle atrophy (HP:0009130)1.90828607
113Ketoacidosis (HP:0001993)1.89793363
114Hypoglycemic coma (HP:0001325)1.88888746
115Hypertriglyceridemia (HP:0002155)1.88152640
116Ragged-red muscle fibers (HP:0003200)1.87823059
117Interstitial pulmonary disease (HP:0006530)1.87642349
118Hemoptysis (HP:0002105)1.87075430
119Lymphopenia (HP:0001888)1.86802350
120Polycythemia (HP:0001901)1.86267097
121Spontaneous hematomas (HP:0007420)1.85597100
122Distal lower limb amyotrophy (HP:0008944)1.85138781
123Sepsis (HP:0100806)1.84148076
124Microretrognathia (HP:0000308)1.83629151
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.83126791
126Rectal prolapse (HP:0002035)1.83010843
127Bronchitis (HP:0012387)1.82554359
128Abnormality of the common coagulation pathway (HP:0010990)1.80835869
129Abnormal vertebral ossification (HP:0100569)1.80773209
130Abnormality of iron homeostasis (HP:0011031)1.80581123
131Pathologic fracture (HP:0002756)1.80419590
132Petechiae (HP:0000967)1.80208863
133Selective tooth agenesis (HP:0001592)1.80125072
134Polygenic inheritance (HP:0010982)1.79601565
135Abnormality of the pons (HP:0007361)1.79485673
136Progressive external ophthalmoplegia (HP:0000590)1.79101285
137Abnormal platelet volume (HP:0011876)1.78897372
138Easy fatigability (HP:0003388)1.78556290
139High pitched voice (HP:0001620)1.77843425
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77771135
141Abnormality of polysaccharide metabolism (HP:0011012)1.77771135
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77771135
143Viral hepatitis (HP:0006562)1.77571459
144Pancreatitis (HP:0001733)1.76525495
145Premature loss of primary teeth (HP:0006323)1.76370433
146Purpura (HP:0000979)1.76205017
147Skin ulcer (HP:0200042)1.75889989
148Gingival bleeding (HP:0000225)1.75844320
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73784330
150Broad palm (HP:0001169)1.73354619
151Pallor (HP:0000980)1.71883850
152Pulmonary infiltrates (HP:0002113)1.71041198
153Hypermelanotic macule (HP:0001034)1.70261801
154Insulin resistance (HP:0000855)1.70152892
155Abnormality of the endocardium (HP:0004306)1.69848491
156Micronodular cirrhosis (HP:0001413)1.69753119
157Upper motor neuron abnormality (HP:0002127)1.69355757
158Thin bony cortex (HP:0002753)1.68471521
159Autoimmune thrombocytopenia (HP:0001973)1.68201128
160Disproportionate tall stature (HP:0001519)1.67835059
161Aseptic necrosis (HP:0010885)1.67573691
162Increased IgM level (HP:0003496)1.67375715
163Pustule (HP:0200039)1.67247182
164Esophageal varix (HP:0002040)1.66908745
165Cellulitis (HP:0100658)1.66807370
166Hyperinsulinemic hypoglycemia (HP:0000825)1.66738495
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.65999165
168Microcytic anemia (HP:0001935)1.65600603
169Increased cerebral lipofuscin (HP:0011813)1.64835632
170Chronic otitis media (HP:0000389)1.63486343
171Abnormality of glycosphingolipid metabolism (HP:0004343)1.63484136
172Mitral valve prolapse (HP:0001634)1.62488297
173Gastrointestinal stroma tumor (HP:0100723)1.61870028
174Abnormal platelet function (HP:0011869)1.59924606
175Impaired platelet aggregation (HP:0003540)1.59924606
176Macrocytic anemia (HP:0001972)1.59222062
177Recurrent fungal infections (HP:0002841)1.59031529
178Increased density of long bones (HP:0006392)1.58218309
179Asymmetric septal hypertrophy (HP:0001670)1.57778032
180Hypoglycemic seizures (HP:0002173)1.57107474
181Emphysema (HP:0002097)1.57082085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.47440163
2TRIB34.34240954
3PKN23.91336770
4BCKDK3.89968873
5EEF2K3.53377792
6MAP3K103.29238242
7RIPK43.25414566
8MAP4K13.14545570
9SMG12.98288116
10PRPF4B2.66951803
11ZAP702.31019791
12TAOK12.19323860
13TNK22.03875442
14MAP3K31.92910507
15NME21.89201289
16EPHB11.87111814
17MAP2K21.76937743
18STK101.76836540
19LRRK21.54475099
20PTK61.53079484
21ICK1.49964729
22TYK21.49253633
23TAOK21.49155056
24FLT31.46161873
25NEK21.45273487
26PASK1.42801176
27GRK61.41729316
28KSR21.39505088
29MARK21.39364754
30CDK41.38985784
31JAK31.35999038
32FGR1.31442819
33SIK31.31415767
34RPS6KB21.31259283
35MAP3K11.29635926
36FES1.29154579
37CDK121.27321712
38IRAK21.24173280
39FGFR41.23733544
40MAP3K141.23286720
41SIK11.22185280
42TTN1.18767254
43MTOR1.18405419
44MAPKAPK31.17325518
45IRAK31.15260407
46MAP3K81.12313743
47PAK21.11871060
48PAK41.10554127
49MAP3K131.09855942
50BLK1.09132404
51SCYL21.08293126
52BTK1.07370419
53TBK11.03786319
54TGFBR21.02339422
55RPS6KA40.99875066
56MAP2K30.90817110
57CDC42BPA0.90174653
58PIM10.89697688
59PDPK10.88073076
60KDR0.87652099
61CSF1R0.86852981
62TAOK30.86334189
63CDC70.85856320
64EIF2AK30.84970786
65MAP3K60.83511087
66DYRK1B0.78873153
67RPS6KC10.77571714
68RPS6KL10.77571714
69SIK20.76597041
70WEE10.74070786
71MAPK110.73317689
72IRAK10.71413510
73CAMK1D0.70199496
74BUB10.69947335
75MATK0.65556477
76DYRK30.65517179
77JAK10.65059949
78JAK20.63114171
79ITK0.62806446
80STK40.62098875
81CSK0.61698180
82TESK10.60879464
83CDK60.60270843
84IRAK40.59146770
85RPS6KA60.58859025
86RPS6KA20.58606661
87SYK0.58271453
88ATR0.58029087
89KIT0.57006697
90MAP3K20.56239235
91RAF10.54351821
92MST1R0.54094068
93TTK0.53074903
94MAP3K70.52968408
95STK380.52248550
96LCK0.51913157
97HCK0.51694053
98MELK0.51588128
99RPS6KA10.51526615
100ALK0.50977675
101PRKG20.50725242
102IKBKB0.50395180
103RIPK10.50252204
104MARK30.49572939
105PDGFRA0.49186124
106MAPK150.48985919
107CDK90.48516659
108CDK70.47913770
109YES10.47110050
110ILK0.46542724
111TGFBR10.45718318
112PDK10.45444410
113TLK10.44301254
114AURKB0.43657107
115TESK20.43605000
116PRKD20.43209098
117PDGFRB0.42502026
118BMX0.42342126
119TEC0.42332272
120PDK30.42314609
121PDK40.42314609
122MAPK120.41744142
123EPHA20.40980069
124PRKCH0.40786712
125SGK30.40230111
126MAPKAPK20.39605840
127TSSK60.39331120
128CLK10.38447490
129CAMK1G0.37838923
130CHEK10.37741928
131HIPK20.37611529
132MAP3K110.37188438
133IKBKE0.34734603
134BRAF0.34474715
135CDK20.33344259
136MAP2K60.33328549
137RET0.32635317
138LYN0.32100224
139FYN0.31612655
140STK30.31432695

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049724.42188829
2Fat digestion and absorption_Homo sapiens_hsa049753.73934345
3Protein digestion and absorption_Homo sapiens_hsa049743.22733407
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.48121265
5DNA replication_Homo sapiens_hsa030302.40292035
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.31940985
7One carbon pool by folate_Homo sapiens_hsa006702.24800144
8Folate biosynthesis_Homo sapiens_hsa007902.03149022
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99223512
10Selenocompound metabolism_Homo sapiens_hsa004501.99195015
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99089952
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86873831
13Glycerolipid metabolism_Homo sapiens_hsa005611.83471929
14Base excision repair_Homo sapiens_hsa034101.82012907
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75818172
16Tuberculosis_Homo sapiens_hsa051521.74456374
17Notch signaling pathway_Homo sapiens_hsa043301.73525300
18Ribosome_Homo sapiens_hsa030101.73179865
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72070478
20Mismatch repair_Homo sapiens_hsa034301.68484031
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68210552
22Biosynthesis of amino acids_Homo sapiens_hsa012301.54766708
23Malaria_Homo sapiens_hsa051441.53246817
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47130853
25TNF signaling pathway_Homo sapiens_hsa046681.41546516
26Other glycan degradation_Homo sapiens_hsa005111.38980548
27B cell receptor signaling pathway_Homo sapiens_hsa046621.36756477
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35636824
29Chemokine signaling pathway_Homo sapiens_hsa040621.32546513
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30082291
31Sulfur relay system_Homo sapiens_hsa041221.27107504
32Lysine degradation_Homo sapiens_hsa003101.26008964
33Hepatitis C_Homo sapiens_hsa051601.25006000
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23808130
35Primary immunodeficiency_Homo sapiens_hsa053401.22921555
36Renal cell carcinoma_Homo sapiens_hsa052111.18181433
37Antigen processing and presentation_Homo sapiens_hsa046121.16841005
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.14257044
39Spliceosome_Homo sapiens_hsa030401.13672678
40RNA transport_Homo sapiens_hsa030131.13342578
41Salmonella infection_Homo sapiens_hsa051321.11881938
42Shigellosis_Homo sapiens_hsa051311.11548977
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05460417
44Influenza A_Homo sapiens_hsa051641.05213604
45N-Glycan biosynthesis_Homo sapiens_hsa005101.02676506
46Chronic myeloid leukemia_Homo sapiens_hsa052201.02459679
47Propanoate metabolism_Homo sapiens_hsa006401.00260891
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99472019
49Prolactin signaling pathway_Homo sapiens_hsa049170.99140216
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.98183210
51African trypanosomiasis_Homo sapiens_hsa051430.98066806
52Acute myeloid leukemia_Homo sapiens_hsa052210.97729032
53Pentose phosphate pathway_Homo sapiens_hsa000300.97068189
54Graft-versus-host disease_Homo sapiens_hsa053320.96954535
55Phagosome_Homo sapiens_hsa041450.93711279
56Protein export_Homo sapiens_hsa030600.93028103
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92084977
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91779003
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91326939
60Viral carcinogenesis_Homo sapiens_hsa052030.91031940
61Endocytosis_Homo sapiens_hsa041440.91012606
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90777919
63Allograft rejection_Homo sapiens_hsa053300.90579784
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.90506825
65ErbB signaling pathway_Homo sapiens_hsa040120.88456700
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87298498
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.86699971
68Carbon metabolism_Homo sapiens_hsa012000.86111931
69Insulin signaling pathway_Homo sapiens_hsa049100.86068715
70Lysosome_Homo sapiens_hsa041420.85998403
71Measles_Homo sapiens_hsa051620.85724987
72Pyrimidine metabolism_Homo sapiens_hsa002400.85513776
73Epstein-Barr virus infection_Homo sapiens_hsa051690.84970245
74Hematopoietic cell lineage_Homo sapiens_hsa046400.82916919
75Fructose and mannose metabolism_Homo sapiens_hsa000510.82511127
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.81863361
77Prostate cancer_Homo sapiens_hsa052150.80827098
78Non-small cell lung cancer_Homo sapiens_hsa052230.78982908
79Pertussis_Homo sapiens_hsa051330.78916790
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.78881562
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.78606705
82Cell cycle_Homo sapiens_hsa041100.78563539
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78450192
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77971385
85Glioma_Homo sapiens_hsa052140.77967208
86Autoimmune thyroid disease_Homo sapiens_hsa053200.77791918
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77664527
88Legionellosis_Homo sapiens_hsa051340.77604389
89Choline metabolism in cancer_Homo sapiens_hsa052310.77364477
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77144225
91Small cell lung cancer_Homo sapiens_hsa052220.75885786
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.74853029
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74085808
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73519343
95GnRH signaling pathway_Homo sapiens_hsa049120.73422331
96Platelet activation_Homo sapiens_hsa046110.72801173
97Homologous recombination_Homo sapiens_hsa034400.72642432
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72252977
99Renin-angiotensin system_Homo sapiens_hsa046140.72170996
100HTLV-I infection_Homo sapiens_hsa051660.71584394
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70844137
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70671218
103p53 signaling pathway_Homo sapiens_hsa041150.70668112
104Inositol phosphate metabolism_Homo sapiens_hsa005620.69851087
105Fatty acid degradation_Homo sapiens_hsa000710.69777181
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69566028
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69436276
108mTOR signaling pathway_Homo sapiens_hsa041500.69431272
109FoxO signaling pathway_Homo sapiens_hsa040680.69106708
110T cell receptor signaling pathway_Homo sapiens_hsa046600.68387453
111Amoebiasis_Homo sapiens_hsa051460.68198585
112Osteoclast differentiation_Homo sapiens_hsa043800.68136980
113Herpes simplex infection_Homo sapiens_hsa051680.67312930
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67282335
115Leishmaniasis_Homo sapiens_hsa051400.67240089
116Apoptosis_Homo sapiens_hsa042100.66230307
117Toxoplasmosis_Homo sapiens_hsa051450.66012171
118Prion diseases_Homo sapiens_hsa050200.65874910
119Insulin resistance_Homo sapiens_hsa049310.65287345
120Nucleotide excision repair_Homo sapiens_hsa034200.65223745
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63192984
122Estrogen signaling pathway_Homo sapiens_hsa049150.61843888
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.61761856
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59440741
125Vitamin digestion and absorption_Homo sapiens_hsa049770.57054909
126Arginine and proline metabolism_Homo sapiens_hsa003300.56577661
127Galactose metabolism_Homo sapiens_hsa000520.56378983
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56270453
129Staphylococcus aureus infection_Homo sapiens_hsa051500.53667414
130Viral myocarditis_Homo sapiens_hsa054160.52871134
131Hepatitis B_Homo sapiens_hsa051610.52377646
132Proteoglycans in cancer_Homo sapiens_hsa052050.51714729
133Pancreatic cancer_Homo sapiens_hsa052120.51252555
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50840144
135Endometrial cancer_Homo sapiens_hsa052130.50616071
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50304681
137MAPK signaling pathway_Homo sapiens_hsa040100.49968917
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49779381
139VEGF signaling pathway_Homo sapiens_hsa043700.48820671
140Bladder cancer_Homo sapiens_hsa052190.48697150
141MicroRNAs in cancer_Homo sapiens_hsa052060.48128593
142Systemic lupus erythematosus_Homo sapiens_hsa053220.47366885
143HIF-1 signaling pathway_Homo sapiens_hsa040660.46016176
144Colorectal cancer_Homo sapiens_hsa052100.44301277
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.44183774
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.43728091
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40091078
148AMPK signaling pathway_Homo sapiens_hsa041520.38796583
149Thyroid cancer_Homo sapiens_hsa052160.38331925
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.37598847
151mRNA surveillance pathway_Homo sapiens_hsa030150.35898077
152Tryptophan metabolism_Homo sapiens_hsa003800.35040158
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34816816
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34225620

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