DHX35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.30034294
2transcription from mitochondrial promoter (GO:0006390)7.48522964
3replication fork processing (GO:0031297)7.17787668
4embryonic process involved in female pregnancy (GO:0060136)7.05956227
5proline metabolic process (GO:0006560)6.87783928
6positive regulation of protein homooligomerization (GO:0032464)6.27309579
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.05966853
8DNA deamination (GO:0045006)5.83845292
9regulation of integrin activation (GO:0033623)5.69668701
10establishment of apical/basal cell polarity (GO:0035089)5.69492864
11oxidative demethylation (GO:0070989)5.68633649
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.52622124
13somatic diversification of immune receptors via somatic mutation (GO:0002566)5.52622124
14DNA strand renaturation (GO:0000733)5.46026441
15regulation of protein homooligomerization (GO:0032462)5.36281806
16mitochondrial DNA metabolic process (GO:0032042)5.29333057
17establishment of monopolar cell polarity (GO:0061162)4.89048524
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.89048524
19mitotic G1 DNA damage checkpoint (GO:0031571)4.87548875
20regulation of translational fidelity (GO:0006450)4.76060255
21viral mRNA export from host cell nucleus (GO:0046784)4.63943830
22poly(A)+ mRNA export from nucleus (GO:0016973)4.57138418
23nuclear pore complex assembly (GO:0051292)4.54987367
24spliceosomal tri-snRNP complex assembly (GO:0000244)4.47454034
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.42384037
26base-excision repair (GO:0006284)4.41325050
27mRNA cleavage (GO:0006379)4.41284869
28telomere maintenance via semi-conservative replication (GO:0032201)4.35422106
29mitotic G1/S transition checkpoint (GO:0044819)4.31115592
30formation of translation preinitiation complex (GO:0001731)4.29468788
31negative regulation of JAK-STAT cascade (GO:0046426)4.29123576
32G1 DNA damage checkpoint (GO:0044783)4.24189584
33embryonic placenta development (GO:0001892)4.23704516
34negative regulation of cell cycle arrest (GO:0071157)4.04563648
35DNA integration (GO:0015074)4.02481860
36regulation of gene silencing by miRNA (GO:0060964)4.01631471
37regulation of gene silencing by RNA (GO:0060966)4.01631471
38regulation of posttranscriptional gene silencing (GO:0060147)4.01631471
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.96628515
40negative regulation of mRNA processing (GO:0050686)3.95461509
41dosage compensation (GO:0007549)3.93491833
42nuclear pore organization (GO:0006999)3.92657099
43positive regulation of developmental pigmentation (GO:0048087)3.90706949
44meiotic chromosome segregation (GO:0045132)3.86194754
45cullin deneddylation (GO:0010388)3.84520717
46DNA topological change (GO:0006265)3.84245274
47positive regulation by host of viral transcription (GO:0043923)3.82144523
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.81459820
49DNA double-strand break processing (GO:0000729)3.80513746
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.80441917
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.80441917
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.80441917
53non-recombinational repair (GO:0000726)3.80001477
54double-strand break repair via nonhomologous end joining (GO:0006303)3.80001477
55regulation of sister chromatid cohesion (GO:0007063)3.77258604
56histone H4-K12 acetylation (GO:0043983)3.75861976
57DNA strand elongation involved in DNA replication (GO:0006271)3.75121452
58regulation of RNA export from nucleus (GO:0046831)3.74670171
59cellular response to ATP (GO:0071318)3.74237239
60regulation of centriole replication (GO:0046599)3.70595969
61positive regulation of protein oligomerization (GO:0032461)3.69491592
62termination of RNA polymerase II transcription (GO:0006369)3.68347236
63cellular response to zinc ion (GO:0071294)3.65771332
64negative regulation of protein oligomerization (GO:0032460)3.64883094
65pore complex assembly (GO:0046931)3.61707279
66DNA replication-dependent nucleosome assembly (GO:0006335)3.60445036
67DNA replication-dependent nucleosome organization (GO:0034723)3.60445036
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56696536
69DNA catabolic process, exonucleolytic (GO:0000738)3.56536973
70telomere maintenance via recombination (GO:0000722)3.56384482
71mitochondrial RNA metabolic process (GO:0000959)3.56190752
72DNA ligation (GO:0006266)3.55148939
73IMP biosynthetic process (GO:0006188)3.54560161
74negative regulation of fatty acid biosynthetic process (GO:0045717)3.53832651
75DNA strand elongation (GO:0022616)3.53582601
76protein K6-linked ubiquitination (GO:0085020)3.53554822
77protein deneddylation (GO:0000338)3.53402809
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.53248905
79apoptotic process involved in morphogenesis (GO:0060561)3.52928641
80chromatin remodeling at centromere (GO:0031055)3.52797807
81DNA replication checkpoint (GO:0000076)3.51868002
82negative regulation of RNA splicing (GO:0033119)3.51530129
83regulation of protein oligomerization (GO:0032459)3.49254453
84regulation of double-strand break repair via homologous recombination (GO:0010569)3.48495312
85convergent extension (GO:0060026)3.47632251
86regulation of mitotic spindle checkpoint (GO:1903504)3.46662509
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46662509
88glutamine family amino acid biosynthetic process (GO:0009084)3.46569304
89face development (GO:0060324)3.45000792
90base-excision repair, AP site formation (GO:0006285)3.44792770
91regulation of DNA damage checkpoint (GO:2000001)3.43981546
92CENP-A containing nucleosome assembly (GO:0034080)3.41246907
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39887622
94pre-miRNA processing (GO:0031054)3.39130053
95DNA demethylation (GO:0080111)3.37642523
96regulation of double-strand break repair (GO:2000779)3.37451006
97purine nucleobase biosynthetic process (GO:0009113)3.35727112
98nodal signaling pathway (GO:0038092)3.35180214
99embryonic camera-type eye development (GO:0031076)3.35176574
100nucleobase biosynthetic process (GO:0046112)3.33698051
101negative regulation of Ras GTPase activity (GO:0034261)3.31688667
102trophectodermal cell differentiation (GO:0001829)3.31430441
103pseudouridine synthesis (GO:0001522)3.27006360
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.24304280
105kinetochore assembly (GO:0051382)3.22554115
106DNA replication initiation (GO:0006270)3.22363381
107determination of adult lifespan (GO:0008340)3.22356750
108establishment of integrated proviral latency (GO:0075713)3.21330017
109maturation of 5.8S rRNA (GO:0000460)3.18783927
110negative regulation of mRNA metabolic process (GO:1903312)3.17692263
111positive regulation of DNA repair (GO:0045739)3.16615513
112positive regulation of chromosome segregation (GO:0051984)3.16593520
113mitotic sister chromatid segregation (GO:0000070)3.15997495
114regulation of mitochondrial translation (GO:0070129)3.15435965
115anatomical structure regression (GO:0060033)3.14126519
116protein-cofactor linkage (GO:0018065)3.13663547
117mitotic sister chromatid cohesion (GO:0007064)3.13268369
118mitotic recombination (GO:0006312)3.11577828
119nuclear envelope reassembly (GO:0031468)3.10316583
120mitotic nuclear envelope reassembly (GO:0007084)3.10316583
121labyrinthine layer development (GO:0060711)3.09595537
122histone exchange (GO:0043486)3.08759268
123mRNA export from nucleus (GO:0006406)3.08386501
124IMP metabolic process (GO:0046040)3.07391477
125mitotic nuclear envelope disassembly (GO:0007077)3.06419018
126recombinational repair (GO:0000725)3.05249749
127telomere maintenance via telomere lengthening (GO:0010833)3.04767988
128folic acid-containing compound biosynthetic process (GO:0009396)3.01440745
129DNA replication-independent nucleosome organization (GO:0034724)2.99729647
130DNA replication-independent nucleosome assembly (GO:0006336)2.99729647
131double-strand break repair via homologous recombination (GO:0000724)2.98924448
132microtubule depolymerization (GO:0007019)2.98525361
133glial cell migration (GO:0008347)2.98375381
134mitochondrial DNA replication (GO:0006264)2.98201224
135resolution of meiotic recombination intermediates (GO:0000712)2.97701869
136DNA unwinding involved in DNA replication (GO:0006268)2.97216806
137regulation of centrosome cycle (GO:0046605)2.95152225
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93411033
139synapsis (GO:0007129)2.92430703
140peptidyl-histidine modification (GO:0018202)2.89948718
141regulation of centrosome duplication (GO:0010824)2.89757974
142protein localization to kinetochore (GO:0034501)2.88183507
143ribosome assembly (GO:0042255)2.88044335
144proteasome assembly (GO:0043248)2.87970640
145tRNA aminoacylation for protein translation (GO:0006418)2.86735989
146amino acid activation (GO:0043038)2.86063180
147tRNA aminoacylation (GO:0043039)2.86063180
148histone H2A acetylation (GO:0043968)2.85876835
149mismatch repair (GO:0006298)2.81281951
150rRNA modification (GO:0000154)2.78062570
151ribosome biogenesis (GO:0042254)2.76490380
152ubiquinone metabolic process (GO:0006743)2.75796063
153DNA geometric change (GO:0032392)2.69923508
154tetrahydrofolate metabolic process (GO:0046653)2.69345059
155DNA duplex unwinding (GO:0032508)2.69004155
156L-serine metabolic process (GO:0006563)2.66665750
157regulation of helicase activity (GO:0051095)2.66242093
158membrane disassembly (GO:0030397)2.66010906
159nuclear envelope disassembly (GO:0051081)2.66010906
160spliceosomal snRNP assembly (GO:0000387)2.65658435
161histone mRNA metabolic process (GO:0008334)2.65205540
162negative regulation of chromosome segregation (GO:0051985)2.65058474
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64378648
164respiratory chain complex IV assembly (GO:0008535)2.63860236
165regulation of telomere maintenance (GO:0032204)2.62136254
166mitotic spindle checkpoint (GO:0071174)2.60948828
167negative regulation of mitotic sister chromatid separation (GO:2000816)2.60933812
168negative regulation of sister chromatid segregation (GO:0033046)2.60933812
169negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.60933812
170negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.60933812
171negative regulation of mitotic sister chromatid segregation (GO:0033048)2.60933812
172rRNA catabolic process (GO:0016075)2.60388861
173rRNA processing (GO:0006364)2.57889509
174double-strand break repair (GO:0006302)2.57330466
175ubiquinone biosynthetic process (GO:0006744)2.56961760
176negative regulation of DNA recombination (GO:0045910)2.56658631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.44279839
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99942987
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.39267345
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.28815615
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.24158219
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.09229786
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.07384353
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93286528
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93286528
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93286528
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65259403
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58151244
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55092039
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53600334
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53455207
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.53176348
17ELK1_19687146_ChIP-ChIP_HELA_Human2.51893430
18ZNF274_21170338_ChIP-Seq_K562_Hela2.49646597
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49180864
20VDR_21846776_ChIP-Seq_THP-1_Human2.46558740
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43763909
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43428851
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41834858
24VDR_23849224_ChIP-Seq_CD4+_Human2.38139599
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31826169
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.26864157
27FOXP3_21729870_ChIP-Seq_TREG_Human2.18823551
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18156400
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.17135425
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16793862
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16489769
32VDR_22108803_ChIP-Seq_LS180_Human2.02008644
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01552658
34* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.00250368
35MYC_22102868_ChIP-Seq_BL_Human1.98346283
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.97152495
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93648270
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92708688
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91756444
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91025814
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91022301
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90155796
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89100160
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86601569
45IGF1R_20145208_ChIP-Seq_DFB_Human1.83840252
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80560005
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.79692340
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77833376
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.77700441
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76578203
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76138424
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72972439
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70150731
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69428039
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67835004
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66852619
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64075105
58* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61178983
59MYC_18940864_ChIP-ChIP_HL60_Human1.60905177
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60305173
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58523257
62IRF1_19129219_ChIP-ChIP_H3396_Human1.57824533
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.57653996
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57069742
65LXR_22292898_ChIP-Seq_THP-1_Human1.57015315
66FUS_26573619_Chip-Seq_HEK293_Human1.56576722
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55759288
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.55304281
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53378473
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52319968
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51613430
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51506303
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50820323
74* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49125752
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48964040
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.47625649
77EWS_26573619_Chip-Seq_HEK293_Human1.47102182
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46917268
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.45708462
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44966252
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42991380
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39892929
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36114166
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35537002
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34264839
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.33083175
87KDM5A_27292631_Chip-Seq_BREAST_Human1.31823271
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31698849
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31152794
90* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30712538
91GABP_19822575_ChIP-Seq_HepG2_Human1.30464771
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29371580
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.28626304
94* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28372535
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.27803297
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27111477
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.26726809
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26198348
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.25158943
100XRN2_22483619_ChIP-Seq_HELA_Human1.24948476
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24733018
102AR_21909140_ChIP-Seq_LNCAP_Human1.24364357
103KDM2B_26808549_Chip-Seq_DND41_Human1.23979711
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.23797501
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22952666
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.22601333
107RACK7_27058665_Chip-Seq_MCF-7_Human1.21571043
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21453770
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20261550
110* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20149371
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19246860
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18242769
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18038505
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17325820
115* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17153659
116DCP1A_22483619_ChIP-Seq_HELA_Human1.15480699
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15452273
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14528864
119ZNF263_19887448_ChIP-Seq_K562_Human1.12709123
120* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12541383
121TAF15_26573619_Chip-Seq_HEK293_Human1.12156916
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10334113
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10093294
124* ETS1_21867929_ChIP-Seq_TH2_Mouse1.09917856
125FLI1_27457419_Chip-Seq_LIVER_Mouse1.08728012
126* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08511157
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08393720
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08200366
129* TTF2_22483619_ChIP-Seq_HELA_Human1.06143552
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05737570
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05110930
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04471954
133CIITA_25753668_ChIP-Seq_RAJI_Human1.04391488
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.03592458
135CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01707429
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01329835
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01283296
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99860828
139* RARB_24833708_ChIP-Seq_LIVER_Mouse0.99368989
140* TFEB_21752829_ChIP-Seq_HELA_Human0.99233943
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97552424
142* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97013144
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96125544
144TCF7_22412390_ChIP-Seq_EML_Mouse0.95757195
145GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92940385
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88795855
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88495261
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86052493
149P300_19829295_ChIP-Seq_ESCs_Human0.85430178
150CBP_20019798_ChIP-Seq_JUKART_Human0.80546618
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80546618
152TP53_22573176_ChIP-Seq_HFKS_Human0.80123879
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79804491
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78058743
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77536285
156HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77467603
157ER_23166858_ChIP-Seq_MCF-7_Human0.77244736
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75384358
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74104852
160* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74069190
161* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71982148
162LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67914153
163* SOX9_26525672_Chip-Seq_HEART_Mouse0.62738406
164GBX2_23144817_ChIP-Seq_PC3_Human0.62643910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.59418532
2MP0009278_abnormal_bone_marrow4.02191856
3MP0005171_absent_coat_pigmentation3.82604168
4MP0010030_abnormal_orbit_morphology3.62694901
5MP0004233_abnormal_muscle_weight3.21443385
6MP0010094_abnormal_chromosome_stability3.14966287
7MP0002009_preneoplasia2.70742526
8MP0000372_irregular_coat_pigmentation2.64007209
9MP0002653_abnormal_ependyma_morphology2.59119522
10MP0003890_abnormal_embryonic-extraembry2.54488337
11MP0008995_early_reproductive_senescence2.40661885
12MP0004957_abnormal_blastocyst_morpholog2.27120469
13MP0003111_abnormal_nucleus_morphology2.20870825
14MP0008877_abnormal_DNA_methylation2.19026773
15MP0005174_abnormal_tail_pigmentation2.15744403
16MP0008058_abnormal_DNA_repair2.15222537
17MP0003136_yellow_coat_color2.13221375
18MP0003806_abnormal_nucleotide_metabolis2.09051585
19MP0001545_abnormal_hematopoietic_system2.06023154
20MP0005397_hematopoietic_system_phenotyp2.06023154
21MP0003283_abnormal_digestive_organ2.05385971
22MP0003786_premature_aging2.04859666
23MP0004133_heterotaxia2.04365625
24MP0010352_gastrointestinal_tract_polyps1.95155700
25MP0003077_abnormal_cell_cycle1.89409801
26MP0002102_abnormal_ear_morphology1.86080395
27MP0003119_abnormal_digestive_system1.84611585
28MP0005076_abnormal_cell_differentiation1.83455782
29MP0006072_abnormal_retinal_apoptosis1.74806280
30MP0002086_abnormal_extraembryonic_tissu1.74712183
31MP0002084_abnormal_developmental_patter1.74443265
32MP0006035_abnormal_mitochondrial_morpho1.74189357
33MP0001293_anophthalmia1.73961984
34MP0001697_abnormal_embryo_size1.72522325
35MP0008932_abnormal_embryonic_tissue1.69609227
36MP0002249_abnormal_larynx_morphology1.65373085
37MP0009697_abnormal_copulation1.63327603
38MP0003693_abnormal_embryo_hatching1.62787231
39MP0002085_abnormal_embryonic_tissue1.59760398
40MP0003172_abnormal_lysosome_physiology1.59003412
41MP0004197_abnormal_fetal_growth/weight/1.58262977
42MP0003567_abnormal_fetal_cardiomyocyte1.56865821
43MP0001529_abnormal_vocalization1.56808382
44MP0003121_genomic_imprinting1.53925260
45MP0001672_abnormal_embryogenesis/_devel1.51397511
46MP0005380_embryogenesis_phenotype1.51397511
47MP0003186_abnormal_redox_activity1.48490391
48MP0000490_abnormal_crypts_of1.47639794
49MP0002269_muscular_atrophy1.46251447
50MP0001730_embryonic_growth_arrest1.44905835
51MP0002938_white_spotting1.43671530
52MP0005075_abnormal_melanosome_morpholog1.42350728
53MP0000350_abnormal_cell_proliferation1.40983688
54MP0003937_abnormal_limbs/digits/tail_de1.39880219
55MP0002282_abnormal_trachea_morphology1.38805449
56MP0000015_abnormal_ear_pigmentation1.37807630
57MP0003453_abnormal_keratinocyte_physiol1.36668575
58MP0001929_abnormal_gametogenesis1.33184902
59MP0006292_abnormal_olfactory_placode1.32414827
60MP0002837_dystrophic_cardiac_calcinosis1.29236737
61MP0000371_diluted_coat_color1.26269794
62MP0003315_abnormal_perineum_morphology1.23979079
63MP0005551_abnormal_eye_electrophysiolog1.23004047
64MP0003984_embryonic_growth_retardation1.22183598
65MP0001661_extended_life_span1.20756992
66MP0002080_prenatal_lethality1.19835238
67MP0000647_abnormal_sebaceous_gland1.18885290
68MP0010307_abnormal_tumor_latency1.17907435
69MP0002088_abnormal_embryonic_growth/wei1.17633952
70MP0001286_abnormal_eye_development1.17427065
71MP0001984_abnormal_olfaction1.16657164
72MP0003950_abnormal_plasma_membrane1.16342089
73MP0008789_abnormal_olfactory_epithelium1.16289100
74MP0008875_abnormal_xenobiotic_pharmacok1.13349692
75MP0002019_abnormal_tumor_incidence1.11687643
76MP0003698_abnormal_male_reproductive1.10022559
77MP0000653_abnormal_sex_gland1.09928429
78MP0000579_abnormal_nail_morphology1.09572343
79MP0002254_reproductive_system_inflammat1.09457634
80MP0003941_abnormal_skin_development1.08996870
81MP0003943_abnormal_hepatobiliary_system1.08107876
82MP0002095_abnormal_skin_pigmentation1.07787066
83MP0002111_abnormal_tail_morphology1.07502918
84MP0000470_abnormal_stomach_morphology1.06409230
85MP0003646_muscle_fatigue1.04569053
86MP0000358_abnormal_cell_content/1.04369144
87MP0002751_abnormal_autonomic_nervous1.02657090
88MP0000462_abnormal_digestive_system1.00895904
89MP0002075_abnormal_coat/hair_pigmentati1.00490195
90MP0005058_abnormal_lysosome_morphology1.00381413
91MP0009672_abnormal_birth_weight1.00252872
92MP0003828_pulmonary_edema1.00078591
93MP0005187_abnormal_penis_morphology0.97274715
94MP0004264_abnormal_extraembryonic_tissu0.95202359
95MP0003122_maternal_imprinting0.95183676
96MP0009703_decreased_birth_body0.94887774
97MP0000313_abnormal_cell_death0.94528667
98MP0002932_abnormal_joint_morphology0.94477294
99MP0000537_abnormal_urethra_morphology0.93594672
100MP0006036_abnormal_mitochondrial_physio0.91864091
101MP0003787_abnormal_imprinting0.91447764
102MP0000639_abnormal_adrenal_gland0.91372595
103MP0001340_abnormal_eyelid_morphology0.91165105
104MP0005266_abnormal_metabolism0.90841025
105MP0010630_abnormal_cardiac_muscle0.90824102
106MP0003137_abnormal_impulse_conducting0.89214229
107MP0000566_synostosis0.88417696
108MP0003935_abnormal_craniofacial_develop0.87023948
109MP0005330_cardiomyopathy0.86538732
110MP0002114_abnormal_axial_skeleton0.84062421
111MP0001145_abnormal_male_reproductive0.83515176
112MP0003755_abnormal_palate_morphology0.82338662
113MP0001764_abnormal_homeostasis0.81733103
114MP0000569_abnormal_digit_pigmentation0.81510787
115MP0002396_abnormal_hematopoietic_system0.81398767
116MP0000427_abnormal_hair_cycle0.79107276
117MP0001188_hyperpigmentation0.77916763
118MP0002405_respiratory_system_inflammati0.77442212
119MP0000383_abnormal_hair_follicle0.76744076
120MP0005408_hypopigmentation0.76641711
121MP0001346_abnormal_lacrimal_gland0.75236338
122MP0005377_hearing/vestibular/ear_phenot0.75185329
123MP0003878_abnormal_ear_physiology0.75185329
124MP0009115_abnormal_fat_cell0.74722265
125MP0003045_fibrosis0.74719314
126MP0000049_abnormal_middle_ear0.74537736
127MP0001119_abnormal_female_reproductive0.73726130
128MP0001186_pigmentation_phenotype0.73555188
129MP0001299_abnormal_eye_distance/0.73490600
130MP0002160_abnormal_reproductive_system0.73110609
131MP0003861_abnormal_nervous_system0.72826538
132MP0000762_abnormal_tongue_morphology0.72705317
133MP0002116_abnormal_craniofacial_bone0.72429374
134MP0002697_abnormal_eye_size0.72067870
135MP0004215_abnormal_myocardial_fiber0.71956402
136MP0000685_abnormal_immune_system0.71179929
137MP0000432_abnormal_head_morphology0.71168049
138MP0002234_abnormal_pharynx_morphology0.71019336
139MP0003718_maternal_effect0.68815826
140MP0003763_abnormal_thymus_physiology0.67352421
141MP0002210_abnormal_sex_determination0.66697116
142MP0008007_abnormal_cellular_replicative0.66299949
143MP0002796_impaired_skin_barrier0.66089138
144MP0000689_abnormal_spleen_morphology0.65595770
145MP0000516_abnormal_urinary_system0.65501730
146MP0005367_renal/urinary_system_phenotyp0.65501730
147MP0003566_abnormal_cell_adhesion0.64574323
148MP0002925_abnormal_cardiovascular_devel0.62491393
149MP0005391_vision/eye_phenotype0.62136228
150MP0000703_abnormal_thymus_morphology0.61783116
151MP0009333_abnormal_splenocyte_physiolog0.61486951
152MP0001784_abnormal_fluid_regulation0.61367788
153MP0002332_abnormal_exercise_endurance0.60214934
154MP0005501_abnormal_skin_physiology0.58850079
155MP0000477_abnormal_intestine_morphology0.58748311
156MP0005253_abnormal_eye_physiology0.58551138
157MP0001324_abnormal_eye_pigmentation0.58305887

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.64116722
2Rectovaginal fistula (HP:0000143)4.96305850
3Rectal fistula (HP:0100590)4.96305850
4Facial hemangioma (HP:0000329)4.92777289
5Annular pancreas (HP:0001734)4.87128007
6Poikiloderma (HP:0001029)4.73887621
7Concave nail (HP:0001598)4.69125927
8Intestinal fistula (HP:0100819)4.60898838
9Pustule (HP:0200039)4.45129274
10Vaginal fistula (HP:0004320)4.31886474
11Increased IgM level (HP:0003496)4.29550465
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.23182611
13Turricephaly (HP:0000262)4.07202474
14Ulnar bowing (HP:0003031)3.95308934
15Hypochromic microcytic anemia (HP:0004840)3.89023136
16Chromsome breakage (HP:0040012)3.81214467
17Alopecia of scalp (HP:0002293)3.75923494
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.74515319
19Short humerus (HP:0005792)3.71401663
20Aplasia/hypoplasia of the humerus (HP:0006507)3.60321260
21Tongue fasciculations (HP:0001308)3.56497924
22Meckel diverticulum (HP:0002245)3.51708888
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.51054594
24Vertebral hypoplasia (HP:0008417)3.51054594
25Colon cancer (HP:0003003)3.50792608
26Intestinal atresia (HP:0011100)3.47355559
27Absent radius (HP:0003974)3.44106206
28Coronal craniosynostosis (HP:0004440)3.42856240
29Orthostatic hypotension (HP:0001278)3.36859750
30Volvulus (HP:0002580)3.35276762
31Selective tooth agenesis (HP:0001592)3.34726193
32Aplasia/Hypoplasia of the uvula (HP:0010293)3.33237525
33Muscle fibrillation (HP:0010546)3.32755737
34Aplasia involving forearm bones (HP:0009822)3.25397659
35Absent forearm bone (HP:0003953)3.25397659
36Anteriorly placed anus (HP:0001545)3.24565140
37Abnormal hemoglobin (HP:0011902)3.11680910
38Broad alveolar ridges (HP:0000187)3.09340192
39Abnormality of male internal genitalia (HP:0000022)3.09286837
40True hermaphroditism (HP:0010459)3.07683858
41Basal cell carcinoma (HP:0002671)3.07666969
42Absent thumb (HP:0009777)3.05002148
43Abnormality of the preputium (HP:0100587)3.04793559
44Male infertility (HP:0003251)3.04246308
45Alacrima (HP:0000522)3.02740898
46Pancreatic islet-cell hyperplasia (HP:0004510)3.00557923
47Short chin (HP:0000331)2.99042717
48Congenital hip dislocation (HP:0001374)2.98913221
49Large for gestational age (HP:0001520)2.93800084
50Pancreatic fibrosis (HP:0100732)2.93062432
51Squamous cell carcinoma (HP:0002860)2.90690244
52Abnormality of chromosome stability (HP:0003220)2.90022306
53Abnormality of the aortic arch (HP:0012303)2.86328595
54Pancreatic cysts (HP:0001737)2.77867839
55Patellar aplasia (HP:0006443)2.77851397
56Abnormality of the astrocytes (HP:0100707)2.77155912
57Astrocytoma (HP:0009592)2.77155912
58Premature graying of hair (HP:0002216)2.74314736
59Partial agenesis of the corpus callosum (HP:0001338)2.73826193
60Albinism (HP:0001022)2.73617317
61Abnormality of midbrain morphology (HP:0002418)2.70672541
62Molar tooth sign on MRI (HP:0002419)2.70672541
63Premature skin wrinkling (HP:0100678)2.69941578
64Dysautonomia (HP:0002459)2.66753951
65Hamartoma (HP:0010566)2.65414200
66Pendular nystagmus (HP:0012043)2.57864091
67Bile duct proliferation (HP:0001408)2.57521274
68Abnormal biliary tract physiology (HP:0012439)2.57521274
69Abnormality of the labia minora (HP:0012880)2.52816198
70Hypotelorism (HP:0000601)2.51122581
71Aplasia/Hypoplasia of the patella (HP:0006498)2.49417795
72Sloping forehead (HP:0000340)2.49360039
73Neoplasm of the oral cavity (HP:0100649)2.44949991
74Bifid uvula (HP:0000193)2.43997314
75Urinary glycosaminoglycan excretion (HP:0003541)2.42345109
76Mucopolysacchariduria (HP:0008155)2.42345109
77Abnormal number of incisors (HP:0011064)2.41288863
78Supernumerary spleens (HP:0009799)2.40302268
79Capillary hemangiomas (HP:0005306)2.39269880
80Acute lymphatic leukemia (HP:0006721)2.39047759
81Increased CSF lactate (HP:0002490)2.37377814
82Decreased lacrimation (HP:0000633)2.36934459
83Vertebral fusion (HP:0002948)2.36282304
84Nephroblastoma (Wilms tumor) (HP:0002667)2.35335298
85Neoplasm of the adrenal cortex (HP:0100641)2.34968676
86Abnormality of the carotid arteries (HP:0005344)2.34219222
87Small intestinal stenosis (HP:0012848)2.33968339
88Duodenal stenosis (HP:0100867)2.33968339
89Choanal stenosis (HP:0000452)2.32228852
90Hypokinesia (HP:0002375)2.30799040
91Clumsiness (HP:0002312)2.29668324
92IgA deficiency (HP:0002720)2.28821299
93Ependymoma (HP:0002888)2.28486227
94Cortical dysplasia (HP:0002539)2.27570203
95Diaphragmatic weakness (HP:0009113)2.25947179
96Microvesicular hepatic steatosis (HP:0001414)2.25333572
97Cerebral aneurysm (HP:0004944)2.23276975
98Hypochromic anemia (HP:0001931)2.22466841
99Clubbing of toes (HP:0100760)2.22171666
100Hepatocellular necrosis (HP:0001404)2.20939645
101Gastrointestinal atresia (HP:0002589)2.20652756
102Hypotrichosis (HP:0001006)2.20569799
103Anencephaly (HP:0002323)2.20566818
104Increased serum lactate (HP:0002151)2.20523102
105Abnormality of DNA repair (HP:0003254)2.19703540
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19424139
107Abnormality of polysaccharide metabolism (HP:0011012)2.19424139
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19424139
109Ectopic kidney (HP:0000086)2.18728870
110Lipid accumulation in hepatocytes (HP:0006561)2.17740521
111Embryonal renal neoplasm (HP:0011794)2.17128219
112Birth length less than 3rd percentile (HP:0003561)2.15790286
113Hypoplasia of the radius (HP:0002984)2.12725751
114Sclerocornea (HP:0000647)2.12346756
115Nephronophthisis (HP:0000090)2.12084965
116Bowing of the arm (HP:0006488)2.11925692
117Bowed forearm bones (HP:0003956)2.11925692
118Acute encephalopathy (HP:0006846)2.11696281
119Split hand (HP:0001171)2.11519651
120Glioma (HP:0009733)2.11039616
121Joint stiffness (HP:0001387)2.09689632
122Myelodysplasia (HP:0002863)2.08208881
123Abnormality of the duodenum (HP:0002246)2.07946185
124Dandy-Walker malformation (HP:0001305)2.06756695
125Increased number of teeth (HP:0011069)2.06314253
126Hepatic necrosis (HP:0002605)2.05660867
127Thyroid-stimulating hormone excess (HP:0002925)2.03870414
128Reticulocytopenia (HP:0001896)2.02822289
129Chronic hepatic failure (HP:0100626)2.02482355
130Mitochondrial inheritance (HP:0001427)2.00559959
131Aplasia of the musculature (HP:0100854)2.00144673
132Abnormality of the ileum (HP:0001549)2.00066493
133Preaxial hand polydactyly (HP:0001177)1.98910316
134Dysostosis multiplex (HP:0000943)1.98117529
135Renal cortical cysts (HP:0000803)1.96918300
136Tubulointerstitial nephritis (HP:0001970)1.95480620
137Growth hormone excess (HP:0000845)1.94645905
138Narrow nasal bridge (HP:0000446)1.92585291
139Duplicated collecting system (HP:0000081)1.91578114
140Acute necrotizing encephalopathy (HP:0006965)1.90805274
141Short 5th finger (HP:0009237)1.90581734
142Bulbar palsy (HP:0001283)1.90025285
143Polycythemia (HP:0001901)1.90024934
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89308464
145Abnormal protein N-linked glycosylation (HP:0012347)1.89308464
146Abnormal protein glycosylation (HP:0012346)1.89308464
147Abnormal glycosylation (HP:0012345)1.89308464
148Medulloblastoma (HP:0002885)1.89075303
149Impulsivity (HP:0100710)1.88457347
150Tented upper lip vermilion (HP:0010804)1.87883893
151Increased hepatocellular lipid droplets (HP:0006565)1.87860813
152Retinal dysplasia (HP:0007973)1.87110381
153Short thumb (HP:0009778)1.86503781
154Abnormality of the renal cortex (HP:0011035)1.83780209
155Oculomotor apraxia (HP:0000657)1.83055219
156Abnormality of endocrine pancreas physiology (HP:0012093)1.81333672
157Abnormality of the pancreatic islet cells (HP:0006476)1.81333672
158Muscle fiber atrophy (HP:0100295)1.80474044
159Hemivertebrae (HP:0002937)1.80029764
160Missing ribs (HP:0000921)1.79859277
161Abnormality of abdominal situs (HP:0011620)1.79838427
162Hyperglycinuria (HP:0003108)1.78882408
163Horseshoe kidney (HP:0000085)1.78563544
164Aplasia/Hypoplasia of the spleen (HP:0010451)1.77622951
165Triphalangeal thumb (HP:0001199)1.75848467
166Inability to walk (HP:0002540)1.75515954
167Astigmatism (HP:0000483)1.75169022
168Abnormality of alanine metabolism (HP:0010916)1.75036114
169Hyperalaninemia (HP:0003348)1.75036114
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75036114
171Hyperglycinemia (HP:0002154)1.74153828
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.74004840
173Optic nerve coloboma (HP:0000588)1.73043050
174Abnormal lung lobation (HP:0002101)1.72806747
175Lactic acidosis (HP:0003128)1.69563398
176Abnormal number of erythroid precursors (HP:0012131)1.69121191
177Progressive inability to walk (HP:0002505)1.68830258
178Prominent metopic ridge (HP:0005487)1.66537167
179Cystic liver disease (HP:0006706)1.66387392
180Male pseudohermaphroditism (HP:0000037)1.66303891
181Abnormality of the renal collecting system (HP:0004742)1.65874736
182Abnormality of the metopic suture (HP:0005556)1.64914009
183Small hand (HP:0200055)1.63619444
184Asplenia (HP:0001746)1.62414329
185Severe visual impairment (HP:0001141)1.62210088
1863-Methylglutaconic aciduria (HP:0003535)1.62048842
187Increased serum pyruvate (HP:0003542)1.61996504
188Abnormality of glycolysis (HP:0004366)1.61903150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.05682607
2MAPK154.75531701
3DDR24.65642331
4MAP3K64.43528159
5SRPK13.76941359
6TSSK63.38705999
7VRK23.34128916
8MAP3K113.24981272
9ZAK3.13418262
10TYRO33.08323159
11PINK12.99495943
12MATK2.99193348
13FGR2.75240912
14EIF2AK32.68288769
15MKNK12.55478856
16PBK2.50473079
17UHMK12.37780628
18DAPK12.29229136
19MKNK22.28161935
20PLK42.21105793
21BMX2.20511164
22PIM22.13642838
23WNK32.13592016
24CSK2.12141604
25TRIM282.12132953
26STK162.10660735
27YES12.10381112
28PRKD22.07688192
29PLK32.05760935
30CDK72.02043368
31VRK11.97516093
32EIF2AK11.93014600
33PDGFRA1.91798732
34MAP4K21.90795682
35NUAK11.88534359
36DYRK1B1.83938453
37PIM11.62271121
38TAF11.52553488
39FRK1.51193530
40CDK61.44646937
41CDK121.37107747
42RPS6KL11.36512240
43RPS6KC11.36512240
44TRPM71.35680530
45MST41.26691415
46INSRR1.25414710
47MAP3K101.23270009
48CHEK21.22992660
49NME11.20618195
50RPS6KA61.19742960
51PNCK1.16735667
52AKT31.15510286
53DYRK21.14676544
54CDC42BPA1.14168583
55BMPR1B1.12513028
56PASK1.10893468
57BCR1.09119236
58PHKG11.09090714
59PHKG21.09090714
60STK391.08238618
61PLK11.05955204
62WNK41.00540318
63LATS20.99927933
64PDK20.98680817
65CDC70.96967406
66PRPF4B0.96815819
67GSK3A0.96414539
68MAPK110.95746845
69ADRBK20.95037579
70BCKDK0.94822566
71WEE10.93680483
72ATR0.93611677
73MAP3K40.90601706
74TNIK0.89906829
75TAOK20.89287948
76EIF2AK20.89123888
77PLK20.88304178
78OXSR10.85432310
79MTOR0.84556523
80DYRK30.83955637
81CSNK1G30.80764355
82RPS6KB20.80353998
83NEK20.79992852
84CSNK1A1L0.79887749
85CDK30.77933306
86NEK10.75811196
87TGFBR10.71216693
88BRSK10.69469921
89RPS6KA10.69292652
90CDK20.65417089
91PRKAA10.65179356
92RPS6KA40.60057058
93HIPK20.59660492
94TRIB30.59086835
95MAPKAPK50.58961442
96CHEK10.58067613
97FGFR20.57715083
98RAF10.55686112
99CSNK1G20.54441414
100ERBB40.52538139
101MAPK130.49477754
102CSNK1E0.48275349
103RPS6KB10.47437937
104CDK40.47049608
105ATM0.46732882
106BUB10.46713634
107EPHA20.46270275
108EGFR0.45873398
109ALK0.45157495
110MAP2K70.44991091
111PDGFRB0.44377629
112CSNK2A10.44090475
113BRD40.42846211
114MAPK10.42057948
115RPS6KA50.41788083
116SMG10.41541908
117CDK10.39941273
118LYN0.39020581
119CDK80.38641638
120AURKA0.36988978
121AURKB0.36770437
122MAPK140.36277968
123GRK70.35874704
124CSNK2A20.35824568
125MET0.35672990
126BRSK20.35476029
127MAPK30.35251987
128CSNK1G10.34502794
129MAP4K10.34286267
130TTK0.33735805
131MAPK100.33731160
132ACVR1B0.32111655
133NLK0.30798633
134CSNK1D0.30092064
135CDK90.29431162
136STK100.28591197
137ERBB30.28321160
138MARK30.28168816
139MAP3K90.27603154
140RIPK10.26949046
141CAMK40.26624915
142CLK10.26521015
143GRK10.25178576
144EPHA30.25129545
145FGFR10.24560889
146DYRK1A0.24471918
147SCYL20.23792967
148AKT20.22790904
149FLT30.22718720
150TLK10.22541310
151PAK40.22239021
152LCK0.22023741
153INSR0.21893277
154GSK3B0.21792585
155STK30.21385258
156AKT10.21260757
157STK40.21071896
158MAPKAPK20.20260505
159MELK0.19970033
160MAPK40.19516111
161PRKAA20.19407249
162PAK20.18643272
163PAK10.18197322
164PRKDC0.17598998
165TNK20.17388511

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.29156928
2Base excision repair_Homo sapiens_hsa034104.85164131
3Fatty acid biosynthesis_Homo sapiens_hsa000614.54704080
4DNA replication_Homo sapiens_hsa030304.40505195
5Nucleotide excision repair_Homo sapiens_hsa034202.64810340
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63343375
7Spliceosome_Homo sapiens_hsa030402.55021706
8RNA transport_Homo sapiens_hsa030132.38219122
9Homologous recombination_Homo sapiens_hsa034402.30784336
10mRNA surveillance pathway_Homo sapiens_hsa030152.29614609
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12131016
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07447279
13Fanconi anemia pathway_Homo sapiens_hsa034602.07044271
14Notch signaling pathway_Homo sapiens_hsa043301.98175219
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96975213
16Propanoate metabolism_Homo sapiens_hsa006401.93813246
17mTOR signaling pathway_Homo sapiens_hsa041501.91280656
18Protein export_Homo sapiens_hsa030601.88855434
19Cell cycle_Homo sapiens_hsa041101.87539080
20Hippo signaling pathway_Homo sapiens_hsa043901.74933681
21Hedgehog signaling pathway_Homo sapiens_hsa043401.73546969
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73413632
23p53 signaling pathway_Homo sapiens_hsa041151.72849688
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63304357
25Circadian rhythm_Homo sapiens_hsa047101.62758028
26Biosynthesis of amino acids_Homo sapiens_hsa012301.56210675
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52587275
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49973398
29Adherens junction_Homo sapiens_hsa045201.45850238
30Purine metabolism_Homo sapiens_hsa002301.42983694
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.40334304
32Arginine and proline metabolism_Homo sapiens_hsa003301.40267671
33Oxidative phosphorylation_Homo sapiens_hsa001901.39418374
34Butanoate metabolism_Homo sapiens_hsa006501.33430616
35Parkinsons disease_Homo sapiens_hsa050121.31963161
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31565441
37Huntingtons disease_Homo sapiens_hsa050161.28859978
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26959773
39TGF-beta signaling pathway_Homo sapiens_hsa043501.24437261
40Fatty acid elongation_Homo sapiens_hsa000621.22884169
41Lysine degradation_Homo sapiens_hsa003101.19313925
42Basal cell carcinoma_Homo sapiens_hsa052171.18422615
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18211843
44Ribosome_Homo sapiens_hsa030101.17178439
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12205551
46One carbon pool by folate_Homo sapiens_hsa006701.10440333
47Oocyte meiosis_Homo sapiens_hsa041141.08088205
48Primary immunodeficiency_Homo sapiens_hsa053401.06512533
49Shigellosis_Homo sapiens_hsa051311.04465715
50Fatty acid metabolism_Homo sapiens_hsa012121.03608202
51Wnt signaling pathway_Homo sapiens_hsa043101.00909928
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00546435
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99013700
54Bladder cancer_Homo sapiens_hsa052190.98428422
55Pyruvate metabolism_Homo sapiens_hsa006200.95677970
56Fructose and mannose metabolism_Homo sapiens_hsa000510.95629680
57Colorectal cancer_Homo sapiens_hsa052100.95198002
58MicroRNAs in cancer_Homo sapiens_hsa052060.92682647
59VEGF signaling pathway_Homo sapiens_hsa043700.92193438
60Sulfur relay system_Homo sapiens_hsa041220.91859786
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89591848
62Viral myocarditis_Homo sapiens_hsa054160.88158677
63Steroid biosynthesis_Homo sapiens_hsa001000.87361965
64RNA degradation_Homo sapiens_hsa030180.85959608
65Carbon metabolism_Homo sapiens_hsa012000.82547093
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81621296
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80847121
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77767757
69Viral carcinogenesis_Homo sapiens_hsa052030.74545272
70Fatty acid degradation_Homo sapiens_hsa000710.74164704
71Tryptophan metabolism_Homo sapiens_hsa003800.73689294
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73257824
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72962322
74Peroxisome_Homo sapiens_hsa041460.72816415
75RNA polymerase_Homo sapiens_hsa030200.72375603
76Metabolic pathways_Homo sapiens_hsa011000.72169046
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69861466
78Alzheimers disease_Homo sapiens_hsa050100.69186495
79Chronic myeloid leukemia_Homo sapiens_hsa052200.68393062
80Folate biosynthesis_Homo sapiens_hsa007900.67747368
81Dorso-ventral axis formation_Homo sapiens_hsa043200.66755872
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66010983
83Phototransduction_Homo sapiens_hsa047440.65938903
84Tight junction_Homo sapiens_hsa045300.65030617
85Small cell lung cancer_Homo sapiens_hsa052220.63974714
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63786502
87Acute myeloid leukemia_Homo sapiens_hsa052210.62521810
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62004271
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61358028
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.61355201
91Basal transcription factors_Homo sapiens_hsa030220.61349128
92Nitrogen metabolism_Homo sapiens_hsa009100.59705710
93Glutathione metabolism_Homo sapiens_hsa004800.59290815
94Epstein-Barr virus infection_Homo sapiens_hsa051690.57914215
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57573916
96Herpes simplex infection_Homo sapiens_hsa051680.56263670
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.55940567
98Galactose metabolism_Homo sapiens_hsa000520.54112727
99Choline metabolism in cancer_Homo sapiens_hsa052310.53216452
100beta-Alanine metabolism_Homo sapiens_hsa004100.52503086
101ErbB signaling pathway_Homo sapiens_hsa040120.51815460
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51339748
103HTLV-I infection_Homo sapiens_hsa051660.50420319
104AMPK signaling pathway_Homo sapiens_hsa041520.50023659
105Thyroid cancer_Homo sapiens_hsa052160.48703667
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48175693
107Non-homologous end-joining_Homo sapiens_hsa034500.47623192
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46027766
109Insulin signaling pathway_Homo sapiens_hsa049100.44584213
110Pyrimidine metabolism_Homo sapiens_hsa002400.44184839
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44008530
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.41932828
113Legionellosis_Homo sapiens_hsa051340.38751549
114Proteasome_Homo sapiens_hsa030500.38440649
115Endometrial cancer_Homo sapiens_hsa052130.38151469
116Gap junction_Homo sapiens_hsa045400.37689525
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37506903
118Proteoglycans in cancer_Homo sapiens_hsa052050.37181266
119Caffeine metabolism_Homo sapiens_hsa002320.36304722
120Vitamin B6 metabolism_Homo sapiens_hsa007500.36238057
121Cardiac muscle contraction_Homo sapiens_hsa042600.35851037
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34625256
123Ether lipid metabolism_Homo sapiens_hsa005650.34194175
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33784025
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32700055
126Pathways in cancer_Homo sapiens_hsa052000.32611066
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31791160
128Hepatitis B_Homo sapiens_hsa051610.31267043
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31179303
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.30806256
131Tyrosine metabolism_Homo sapiens_hsa003500.30371356
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29848391
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29766367
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29635180
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29113915
136HIF-1 signaling pathway_Homo sapiens_hsa040660.28595224
137Sulfur metabolism_Homo sapiens_hsa009200.28249769
138B cell receptor signaling pathway_Homo sapiens_hsa046620.26856651
139MAPK signaling pathway_Homo sapiens_hsa040100.26791437
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26065583
141ABC transporters_Homo sapiens_hsa020100.25259262
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25126571
143Chemical carcinogenesis_Homo sapiens_hsa052040.24919159
144Retinol metabolism_Homo sapiens_hsa008300.24520641
145Focal adhesion_Homo sapiens_hsa045100.23643492
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23027027
147Systemic lupus erythematosus_Homo sapiens_hsa053220.22245131
148Prostate cancer_Homo sapiens_hsa052150.21774697
149Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21422635
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20645667
151Arginine biosynthesis_Homo sapiens_hsa002200.18549487
152Selenocompound metabolism_Homo sapiens_hsa004500.17575932
153Pancreatic cancer_Homo sapiens_hsa052120.16943948
154N-Glycan biosynthesis_Homo sapiens_hsa005100.15502063
155Measles_Homo sapiens_hsa051620.14535833
156Endocytosis_Homo sapiens_hsa041440.12876926

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