DHX36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.51767887
2pre-miRNA processing (GO:0031054)4.48462338
3nuclear pore organization (GO:0006999)4.15847044
4mitotic sister chromatid cohesion (GO:0007064)4.05817924
5negative regulation of translation, ncRNA-mediated (GO:0040033)4.03569803
6regulation of translation, ncRNA-mediated (GO:0045974)4.03569803
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.03569803
8layer formation in cerebral cortex (GO:0021819)3.87175905
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86661889
10mRNA splice site selection (GO:0006376)3.74867777
11positive regulation of dendritic spine morphogenesis (GO:0061003)3.55059554
12neuron cell-cell adhesion (GO:0007158)3.51042717
13chromatin remodeling at centromere (GO:0031055)3.47117757
14replication fork processing (GO:0031297)3.44895420
15centriole replication (GO:0007099)3.36297606
16single strand break repair (GO:0000012)3.34053542
17locomotory exploration behavior (GO:0035641)3.31032939
18negative regulation of histone methylation (GO:0031061)3.30780258
19histone exchange (GO:0043486)3.29703147
20regulation of histone H3-K9 methylation (GO:0051570)3.26458887
21CENP-A containing nucleosome assembly (GO:0034080)3.25657072
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24853705
23DNA unwinding involved in DNA replication (GO:0006268)3.23552447
24regulation of RNA export from nucleus (GO:0046831)3.14138768
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.11871114
26regulation of mitotic spindle checkpoint (GO:1903504)3.04916517
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04916517
28regulation of DNA endoreduplication (GO:0032875)3.04720107
29response to pheromone (GO:0019236)3.04506120
30axonal fasciculation (GO:0007413)3.04292435
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03827785
32DNA topological change (GO:0006265)3.03083941
33synaptic vesicle maturation (GO:0016188)3.02453129
34DNA double-strand break processing (GO:0000729)3.00356208
35negative regulation of DNA repair (GO:0045738)2.98220525
36neuron recognition (GO:0008038)2.95507138
37pore complex assembly (GO:0046931)2.94357649
38pyrimidine nucleobase catabolic process (GO:0006208)2.92194793
39regulation of centrosome duplication (GO:0010824)2.88166958
40histone H3-K9 methylation (GO:0051567)2.87331922
41regulation of centrosome cycle (GO:0046605)2.84091287
42olfactory bulb development (GO:0021772)2.82855775
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82384844
44microtubule depolymerization (GO:0007019)2.82300154
45telomere maintenance via telomerase (GO:0007004)2.81495506
46microtubule anchoring (GO:0034453)2.80544076
47monoubiquitinated protein deubiquitination (GO:0035520)2.80325685
48dosage compensation (GO:0007549)2.80319978
49cytoplasmic mRNA processing body assembly (GO:0033962)2.76344848
50chromatin assembly (GO:0031497)2.76238764
51regulation of helicase activity (GO:0051095)2.75980043
52kinetochore assembly (GO:0051382)2.75508060
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74581433
54neuronal stem cell maintenance (GO:0097150)2.74132090
55regulation of centriole replication (GO:0046599)2.72567510
56DNA replication-independent nucleosome organization (GO:0034724)2.72496745
57DNA replication-independent nucleosome assembly (GO:0006336)2.72496745
58hindbrain development (GO:0030902)2.70857031
59protein localization to synapse (GO:0035418)2.69151196
60regulation of glutamate receptor signaling pathway (GO:1900449)2.67337021
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65771869
62negative regulation of DNA recombination (GO:0045910)2.65572609
63regulation of dendritic spine morphogenesis (GO:0061001)2.65031893
64regulation of mRNA splicing, via spliceosome (GO:0048024)2.63776698
65central nervous system projection neuron axonogenesis (GO:0021952)2.62823283
66dendrite morphogenesis (GO:0048813)2.61893843
67otic vesicle formation (GO:0030916)2.60985408
68neural tube formation (GO:0001841)2.60969366
69regulation of timing of cell differentiation (GO:0048505)2.60499054
70vesicle transport along microtubule (GO:0047496)2.58582302
71peptidyl-lysine dimethylation (GO:0018027)2.57819704
72histone H3-K9 demethylation (GO:0033169)2.57701081
73alternative mRNA splicing, via spliceosome (GO:0000380)2.57174365
74regulation of nucleobase-containing compound transport (GO:0032239)2.56342131
75dendritic spine morphogenesis (GO:0060997)2.55841061
76exploration behavior (GO:0035640)2.55790798
77presynaptic membrane assembly (GO:0097105)2.55645314
78postsynaptic membrane organization (GO:0001941)2.55364915
79innervation (GO:0060384)2.55240080
80double-strand break repair via homologous recombination (GO:0000724)2.55226116
81synapsis (GO:0007129)2.54281137
82dorsal/ventral axis specification (GO:0009950)2.53667187
83DNA damage response, detection of DNA damage (GO:0042769)2.53323168
84regulation of posttranscriptional gene silencing (GO:0060147)2.53313789
85regulation of gene silencing by miRNA (GO:0060964)2.53313789
86regulation of gene silencing by RNA (GO:0060966)2.53313789
87recombinational repair (GO:0000725)2.53094206
88establishment of protein localization to mitochondrial membrane (GO:0090151)2.53087598
89intraciliary transport (GO:0042073)2.52029596
90negative regulation of histone modification (GO:0031057)2.49762012
91regulation of sister chromatid cohesion (GO:0007063)2.48654550
92resolution of meiotic recombination intermediates (GO:0000712)2.47087591
93cerebral cortex development (GO:0021987)2.46631810
94negative regulation of histone acetylation (GO:0035067)2.46394472
95regulation of synaptic vesicle exocytosis (GO:2000300)2.46090266
96genetic imprinting (GO:0071514)2.46050946
97regulation of development, heterochronic (GO:0040034)2.45653001
98spindle checkpoint (GO:0031577)2.45458403
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.44643823
100tachykinin receptor signaling pathway (GO:0007217)2.44437143
101retinal ganglion cell axon guidance (GO:0031290)2.44399266
102histone H2A acetylation (GO:0043968)2.44306919
103sister chromatid cohesion (GO:0007062)2.44282994
104glutamate secretion (GO:0014047)2.42976128
105transmission of nerve impulse (GO:0019226)2.42499508
106mitotic spindle checkpoint (GO:0071174)2.42353607
107glucocorticoid receptor signaling pathway (GO:0042921)2.42059815
108microtubule organizing center organization (GO:0031023)2.41923134
109glutamate receptor signaling pathway (GO:0007215)2.41333331
110DNA duplex unwinding (GO:0032508)2.40722759
111heterochromatin organization (GO:0070828)2.40256877
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38710608
113centrosome organization (GO:0051297)2.38442402
114DNA geometric change (GO:0032392)2.38155080
115stress granule assembly (GO:0034063)2.37309771
116DNA replication checkpoint (GO:0000076)2.37232030
117organelle transport along microtubule (GO:0072384)2.36998961
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.36314242
119negative regulation of sister chromatid segregation (GO:0033046)2.36314242
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.36314242
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.36314242
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.36314242
123peptidyl-arginine N-methylation (GO:0035246)2.35405577
124peptidyl-arginine methylation (GO:0018216)2.35405577
125rRNA methylation (GO:0031167)2.35362791
126regulation of gene expression by genetic imprinting (GO:0006349)2.34983678
127reciprocal DNA recombination (GO:0035825)2.34849868
128reciprocal meiotic recombination (GO:0007131)2.34849868
129negative regulation of chromatin modification (GO:1903309)2.34598748
130somite development (GO:0061053)2.34536648
131cell migration in hindbrain (GO:0021535)2.34504399
132interkinetic nuclear migration (GO:0022027)2.34448713
133negative regulation of mRNA metabolic process (GO:1903312)2.34201215
134somite rostral/caudal axis specification (GO:0032525)2.34074631
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34012123
136histone H3-K9 modification (GO:0061647)2.33606702
137histone mRNA catabolic process (GO:0071044)2.33048158
138kidney morphogenesis (GO:0060993)2.32846405
139metaphase plate congression (GO:0051310)2.31831843
140synaptic transmission, glutamatergic (GO:0035249)2.31450907
141establishment of protein localization to Golgi (GO:0072600)2.31074711
142limb bud formation (GO:0060174)2.30915392
143nucleobase catabolic process (GO:0046113)2.30838539
144positive regulation of mRNA processing (GO:0050685)2.30831356
145histone H2A monoubiquitination (GO:0035518)2.30796713
146regulation of mitotic sister chromatid separation (GO:0010965)2.30711487
147regulation of mitotic sister chromatid segregation (GO:0033047)2.30711487
148regulation of sister chromatid segregation (GO:0033045)2.30711487
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.30104383
150double-strand break repair via nonhomologous end joining (GO:0006303)2.29712023
151non-recombinational repair (GO:0000726)2.29712023
152dendrite development (GO:0016358)2.29344547
153startle response (GO:0001964)2.29226321
154negative regulation of chromosome segregation (GO:0051985)2.29023800
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.28661104
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.28661104
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28322299
158negative regulation of mRNA processing (GO:0050686)2.27489020
159ATP-dependent chromatin remodeling (GO:0043044)2.27455911
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.27163244
161kinetochore organization (GO:0051383)2.27098654
162IMP biosynthetic process (GO:0006188)2.26978418
163peptidyl-arginine omega-N-methylation (GO:0035247)2.26325632
164sister chromatid segregation (GO:0000819)2.26102233
165regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.26033699
166glial cell proliferation (GO:0014009)2.25491066
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.25170293
168DNA replication-dependent nucleosome assembly (GO:0006335)2.24977834
169DNA replication-dependent nucleosome organization (GO:0034723)2.24977834
170cerebellum development (GO:0021549)2.24912563
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.24877347
172negative regulation of transcription regulatory region DNA binding (GO:2000678)2.23468354
173presynaptic membrane organization (GO:0097090)2.23454026
174regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.23145687
175synaptic vesicle exocytosis (GO:0016079)2.22923428
176regulation of meiosis I (GO:0060631)2.22614006
177regulation of mRNA processing (GO:0050684)2.22530856
178neuron-neuron synaptic transmission (GO:0007270)2.22318520
179mRNA transport (GO:0051028)2.22121326
180positive regulation of dendrite morphogenesis (GO:0050775)2.21974731
181histone mRNA metabolic process (GO:0008334)2.21916176
182* regulation of telomere maintenance (GO:0032204)2.21623801
183rRNA modification (GO:0000154)2.21313219
184regulation of non-canonical Wnt signaling pathway (GO:2000050)2.21183176
185regulation of glycogen (starch) synthase activity (GO:2000465)2.19857002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.94030102
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.29011292
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.76856113
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24954735
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.06687868
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02821287
7EZH2_22144423_ChIP-Seq_EOC_Human2.92069869
8GBX2_23144817_ChIP-Seq_PC3_Human2.59199429
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.45306829
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42966757
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41984218
12TAF15_26573619_Chip-Seq_HEK293_Human2.33592134
13FUS_26573619_Chip-Seq_HEK293_Human2.32418268
14IGF1R_20145208_ChIP-Seq_DFB_Human2.30707461
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25742323
16VDR_22108803_ChIP-Seq_LS180_Human2.25282736
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.12444491
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12357706
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10161355
20EWS_26573619_Chip-Seq_HEK293_Human2.08699439
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.04673322
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03550569
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00970913
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.99141290
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92742226
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89086585
27ELK1_19687146_ChIP-ChIP_HELA_Human1.88050021
28* GABP_17652178_ChIP-ChIP_JURKAT_Human1.87970228
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84900402
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84335626
31AR_21572438_ChIP-Seq_LNCaP_Human1.69996750
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69663757
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69470004
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.67110802
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66127461
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63598263
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60888389
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60042215
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.58248804
40P300_19829295_ChIP-Seq_ESCs_Human1.51552540
41SMAD4_21799915_ChIP-Seq_A2780_Human1.49196413
42ZNF274_21170338_ChIP-Seq_K562_Hela1.47662896
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47621266
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43296822
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41739819
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41314403
47SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40908223
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39797139
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39697509
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39261175
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.38779918
52STAT3_23295773_ChIP-Seq_U87_Human1.38058246
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37942768
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.37370403
55CBP_20019798_ChIP-Seq_JUKART_Human1.36338068
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36338068
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.36184668
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35878976
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35017268
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.34415556
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34398103
62* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33219360
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31708453
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31083838
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30933118
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29907603
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29397525
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29314125
69* PIAS1_25552417_ChIP-Seq_VCAP_Human1.29042507
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28901915
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28335434
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28115710
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27914345
74SOX9_26525672_Chip-Seq_HEART_Mouse1.27760481
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.26054897
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25951650
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24420513
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23675384
79MYC_18940864_ChIP-ChIP_HL60_Human1.22750724
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22023378
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21587681
82ER_23166858_ChIP-Seq_MCF-7_Human1.20618387
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19105231
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.19011120
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18507171
86TCF4_23295773_ChIP-Seq_U87_Human1.18101930
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.16411166
88* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16407065
89* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16407065
90RNF2_27304074_Chip-Seq_NSC_Mouse1.15790981
91REST_21632747_ChIP-Seq_MESCs_Mouse1.15561395
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15059968
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14424294
94* AR_25329375_ChIP-Seq_VCAP_Human1.14389775
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.14169504
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.13637341
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13232458
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13207520
99* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12516392
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12458457
101BCAT_22108803_ChIP-Seq_LS180_Human1.12340121
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11547483
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.10584845
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.08793784
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.08448826
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07701378
107TCF4_22108803_ChIP-Seq_LS180_Human1.07300233
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06679022
109* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06619327
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05698029
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.05474249
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05239458
113P53_22387025_ChIP-Seq_ESCs_Mouse1.05175799
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04866841
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04681689
116TP53_16413492_ChIP-PET_HCT116_Human1.04146215
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.02435749
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01937008
119JUN_21703547_ChIP-Seq_K562_Human1.01174494
120IRF1_19129219_ChIP-ChIP_H3396_Human1.00991815
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00242689
122* VDR_23849224_ChIP-Seq_CD4+_Human1.00219532
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99526203
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99160378
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99137512
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99124454
127AR_19668381_ChIP-Seq_PC3_Human0.99059905
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98180395
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98030527
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95106135
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94815950
132RUNX2_22187159_ChIP-Seq_PCA_Human0.94640939
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.94208177
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94012922
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92402329
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90725240
137RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90725240
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90495084
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89324799
140* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88801584
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.88629286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.58887036
2MP0000569_abnormal_digit_pigmentation3.13428807
3MP0003123_paternal_imprinting3.08606498
4MP0003121_genomic_imprinting3.04614080
5MP0004859_abnormal_synaptic_plasticity3.03989957
6MP0003880_abnormal_central_pattern2.81547173
7MP0000778_abnormal_nervous_system2.25532455
8MP0003122_maternal_imprinting2.17205427
9MP0008877_abnormal_DNA_methylation2.17176484
10MP0003635_abnormal_synaptic_transmissio2.13290989
11MP0003693_abnormal_embryo_hatching2.05094191
12MP0003890_abnormal_embryonic-extraembry1.91876754
13MP0000537_abnormal_urethra_morphology1.88350581
14MP0005248_abnormal_Harderian_gland1.85386175
15MP0002063_abnormal_learning/memory/cond1.85034789
16MP0008057_abnormal_DNA_replication1.84067615
17MP0001188_hyperpigmentation1.82242852
18MP0004270_analgesia1.70805034
19MP0002102_abnormal_ear_morphology1.69169781
20MP0005423_abnormal_somatic_nervous1.68165569
21MP0010094_abnormal_chromosome_stability1.64773397
22MP0003937_abnormal_limbs/digits/tail_de1.58031615
23MP0002184_abnormal_innervation1.57684691
24MP0009745_abnormal_behavioral_response1.56378674
25MP0000566_synostosis1.55424878
26MP0003861_abnormal_nervous_system1.48215664
27MP0006292_abnormal_olfactory_placode1.47908873
28MP0005645_abnormal_hypothalamus_physiol1.47897183
29MP0005499_abnormal_olfactory_system1.45434209
30MP0005394_taste/olfaction_phenotype1.45434209
31MP0010030_abnormal_orbit_morphology1.44728841
32MP0003718_maternal_effect1.44243104
33MP0001486_abnormal_startle_reflex1.44022804
34MP0003941_abnormal_skin_development1.40702574
35MP0003111_abnormal_nucleus_morphology1.40635152
36MP0002084_abnormal_developmental_patter1.39860937
37MP0005646_abnormal_pituitary_gland1.38091745
38MP0000631_abnormal_neuroendocrine_gland1.38071273
39MP0002638_abnormal_pupillary_reflex1.35023875
40MP0000955_abnormal_spinal_cord1.33514467
41MP0005253_abnormal_eye_physiology1.33509068
42MP0004811_abnormal_neuron_physiology1.31066626
43MP0002152_abnormal_brain_morphology1.29576079
44MP0001984_abnormal_olfaction1.28942458
45MP0002736_abnormal_nociception_after1.28050490
46MP0002572_abnormal_emotion/affect_behav1.27984134
47MP0005623_abnormal_meninges_morphology1.26483208
48MP0001529_abnormal_vocalization1.26435100
49MP0004197_abnormal_fetal_growth/weight/1.26062446
50MP0001177_atelectasis1.25908278
51MP0005551_abnormal_eye_electrophysiolog1.24635626
52MP0005367_renal/urinary_system_phenotyp1.23974913
53MP0000516_abnormal_urinary_system1.23974913
54MP0006072_abnormal_retinal_apoptosis1.23808174
55MP0003385_abnormal_body_wall1.23647715
56MP0004885_abnormal_endolymph1.23568791
57MP0008789_abnormal_olfactory_epithelium1.22926345
58MP0001293_anophthalmia1.21404009
59MP0004133_heterotaxia1.20556762
60MP0002064_seizures1.19151969
61MP0003119_abnormal_digestive_system1.17708534
62MP0009703_decreased_birth_body1.17667264
63MP0005386_behavior/neurological_phenoty1.16761912
64MP0004924_abnormal_behavior1.16761912
65MP0003567_abnormal_fetal_cardiomyocyte1.16241382
66MP0000427_abnormal_hair_cycle1.14566798
67MP0009046_muscle_twitch1.14104551
68MP0001730_embryonic_growth_arrest1.13896840
69MP0002751_abnormal_autonomic_nervous1.13031250
70MP0001485_abnormal_pinna_reflex1.12408125
71MP0002882_abnormal_neuron_morphology1.11868121
72MP0004957_abnormal_blastocyst_morpholog1.11609138
73MP0003115_abnormal_respiratory_system1.11005797
74MP0002067_abnormal_sensory_capabilities1.10708634
75MP0005187_abnormal_penis_morphology1.09733786
76MP0003136_yellow_coat_color1.09523306
77MP0003283_abnormal_digestive_organ1.09156431
78MP0002557_abnormal_social/conspecific_i1.08485521
79MP0001299_abnormal_eye_distance/1.08206508
80MP0002085_abnormal_embryonic_tissue1.08051137
81MP0008932_abnormal_embryonic_tissue1.07969751
82MP0000428_abnormal_craniofacial_morphol1.07245226
83MP0008007_abnormal_cellular_replicative1.06747127
84MP0002081_perinatal_lethality1.06212273
85MP0003755_abnormal_palate_morphology1.05747017
86MP0002734_abnormal_mechanical_nocicepti1.05315291
87MP0005391_vision/eye_phenotype1.05168041
88MP0008995_early_reproductive_senescence1.04877457
89MP0002210_abnormal_sex_determination1.04517520
90MP0000534_abnormal_ureter_morphology1.03526797
91MP0003077_abnormal_cell_cycle1.02729237
92MP0003942_abnormal_urinary_system1.02681522
93MP0002272_abnormal_nervous_system1.01571937
94MP0000647_abnormal_sebaceous_gland1.01352256
95MP0001929_abnormal_gametogenesis1.01242439
96MP0009672_abnormal_birth_weight1.00872330
97MP0000350_abnormal_cell_proliferation1.00459437
98MP0009053_abnormal_anal_canal0.99814275
99MP0002234_abnormal_pharynx_morphology0.99736520
100MP0008058_abnormal_DNA_repair0.99307761
101MP0003935_abnormal_craniofacial_develop0.98069963
102MP0000015_abnormal_ear_pigmentation0.97487376
103MP0003698_abnormal_male_reproductive0.97064983
104MP0005380_embryogenesis_phenotype0.96470286
105MP0001672_abnormal_embryogenesis/_devel0.96470286
106MP0000372_irregular_coat_pigmentation0.96058035
107MP0010307_abnormal_tumor_latency0.94430557
108MP0002752_abnormal_somatic_nervous0.93396130
109MP0009697_abnormal_copulation0.93349611
110MP0010234_abnormal_vibrissa_follicle0.93146687
111MP0001697_abnormal_embryo_size0.92739597
112MP0002233_abnormal_nose_morphology0.92090145
113MP0002160_abnormal_reproductive_system0.90623637
114MP0002254_reproductive_system_inflammat0.90596901
115MP0000049_abnormal_middle_ear0.90505082
116MP0004742_abnormal_vestibular_system0.90121916
117MP0002938_white_spotting0.90119956
118MP0001145_abnormal_male_reproductive0.89944371
119MP0001286_abnormal_eye_development0.89825315
120MP0010352_gastrointestinal_tract_polyps0.88754796
121MP0002177_abnormal_outer_ear0.88597371
122MP0002086_abnormal_extraembryonic_tissu0.88417524
123MP0000653_abnormal_sex_gland0.86919371
124MP0002697_abnormal_eye_size0.85979939
125MP0005195_abnormal_posterior_eye0.85596806
126MP0003632_abnormal_nervous_system0.84459288
127MP0002114_abnormal_axial_skeleton0.83345049
128MP0002088_abnormal_embryonic_growth/wei0.83344849
129MP0002163_abnormal_gland_morphology0.82264854
130MP0006276_abnormal_autonomic_nervous0.82023629
131MP0001968_abnormal_touch/_nociception0.81450444
132MP0003984_embryonic_growth_retardation0.81337231
133MP0003938_abnormal_ear_development0.81270325
134MP0003786_premature_aging0.79874184
135MP0005410_abnormal_fertilization0.77945027
136MP0002111_abnormal_tail_morphology0.76794203

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.59645325
2Hepatoblastoma (HP:0002884)3.13865445
3Volvulus (HP:0002580)3.11697020
4Diastasis recti (HP:0001540)2.84074421
5Pancreatic fibrosis (HP:0100732)2.69846717
6Chromsome breakage (HP:0040012)2.62717397
7Facial hemangioma (HP:0000329)2.61825723
8Nephronophthisis (HP:0000090)2.61521964
9Pancreatic cysts (HP:0001737)2.58878143
10Papillary thyroid carcinoma (HP:0002895)2.57718216
11Septo-optic dysplasia (HP:0100842)2.53643087
12Oligodactyly (hands) (HP:0001180)2.50933319
13Vertebral arch anomaly (HP:0008438)2.50528307
14Abnormality of chromosome stability (HP:0003220)2.49520546
15Drooling (HP:0002307)2.42210450
16Excessive salivation (HP:0003781)2.42210450
17Supernumerary spleens (HP:0009799)2.40771527
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.40486083
19Short 4th metacarpal (HP:0010044)2.39440595
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39440595
21Abnormality of midbrain morphology (HP:0002418)2.37079863
22Molar tooth sign on MRI (HP:0002419)2.37079863
23Astrocytoma (HP:0009592)2.34667741
24Abnormality of the astrocytes (HP:0100707)2.34667741
25Colon cancer (HP:0003003)2.34473135
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.30538077
27Impaired vibration sensation in the lower limbs (HP:0002166)2.27109127
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26924097
29Optic nerve hypoplasia (HP:0000609)2.25001097
30Abnormality of the renal medulla (HP:0100957)2.24267713
31Shoulder girdle muscle weakness (HP:0003547)2.24027748
32Broad alveolar ridges (HP:0000187)2.23678386
33Abnormal hair whorl (HP:0010721)2.20997416
34Aqueductal stenosis (HP:0002410)2.20801085
35True hermaphroditism (HP:0010459)2.20039458
36Meckel diverticulum (HP:0002245)2.18524518
37Papilledema (HP:0001085)2.17995820
38Insidious onset (HP:0003587)2.16719070
39Termporal pattern (HP:0011008)2.16719070
40Abnormality of the ileum (HP:0001549)2.14235198
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13302715
42Macroorchidism (HP:0000053)2.12234430
43Abnormality of the corticospinal tract (HP:0002492)2.10295902
44Inappropriate behavior (HP:0000719)2.09435043
45Chronic hepatic failure (HP:0100626)2.09308073
46Ectopic kidney (HP:0000086)2.06146641
47Absent frontal sinuses (HP:0002688)2.05603006
48Protruding tongue (HP:0010808)2.04501905
49Medial flaring of the eyebrow (HP:0010747)2.00320207
50Obsessive-compulsive behavior (HP:0000722)1.99406194
51Sloping forehead (HP:0000340)1.99203142
52Labial hypoplasia (HP:0000066)1.98507418
53Urinary bladder sphincter dysfunction (HP:0002839)1.97845597
54Heterotopia (HP:0002282)1.96795844
55Abnormal pancreas size (HP:0012094)1.96096856
56Gastroesophageal reflux (HP:0002020)1.95605648
57Abnormality of the septum pellucidum (HP:0007375)1.92712688
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91725649
59Degeneration of the lateral corticospinal tracts (HP:0002314)1.91725649
60Pelvic girdle muscle weakness (HP:0003749)1.90831339
61Focal motor seizures (HP:0011153)1.90656759
62Glioma (HP:0009733)1.90622387
63Action tremor (HP:0002345)1.90264119
64Progressive cerebellar ataxia (HP:0002073)1.89557684
65Vaginal atresia (HP:0000148)1.89411965
66Abnormality of the lower motor neuron (HP:0002366)1.89394865
67Hypoplastic female external genitalia (HP:0012815)1.87567786
68Abnormality of the duodenum (HP:0002246)1.87018950
69Oligodactyly (HP:0012165)1.86864222
70Midline defect of the nose (HP:0004122)1.85952982
71Absent speech (HP:0001344)1.85657987
72Dandy-Walker malformation (HP:0001305)1.84884555
73Bifid tongue (HP:0010297)1.84682135
74Thyroid carcinoma (HP:0002890)1.84551527
75Annular pancreas (HP:0001734)1.84334231
76Pendular nystagmus (HP:0012043)1.83338739
77Medulloblastoma (HP:0002885)1.83337412
78Atonic seizures (HP:0010819)1.82124003
79Impaired smooth pursuit (HP:0007772)1.82040215
80Triphalangeal thumb (HP:0001199)1.81080640
81Resting tremor (HP:0002322)1.80952878
82Growth hormone deficiency (HP:0000824)1.80920729
83Absent septum pellucidum (HP:0001331)1.80597635
84Fair hair (HP:0002286)1.80282404
85Abnormality of ocular smooth pursuit (HP:0000617)1.80222920
86Neoplasm of the oral cavity (HP:0100649)1.79893968
87Duodenal stenosis (HP:0100867)1.79841470
88Small intestinal stenosis (HP:0012848)1.79841470
89Abnormality of the renal cortex (HP:0011035)1.79783341
90Neoplasm of the adrenal cortex (HP:0100641)1.79609450
91Broad ribs (HP:0000885)1.78824299
92Bilateral microphthalmos (HP:0007633)1.78820756
93Urinary urgency (HP:0000012)1.78423204
94Nephroblastoma (Wilms tumor) (HP:0002667)1.77904489
95Absent radius (HP:0003974)1.77802371
96Small hand (HP:0200055)1.77412849
97Rhabdomyosarcoma (HP:0002859)1.77053188
98Broad-based gait (HP:0002136)1.76463526
99Esophageal atresia (HP:0002032)1.75457825
100Spinal cord lesions (HP:0100561)1.75152858
101Syringomyelia (HP:0003396)1.75152858
102Gait imbalance (HP:0002141)1.74960163
103Gaze-evoked nystagmus (HP:0000640)1.74729338
104Intestinal atresia (HP:0011100)1.74476118
105Amyotrophic lateral sclerosis (HP:0007354)1.74463033
106Focal seizures (HP:0007359)1.74451563
107Ankyloglossia (HP:0010296)1.74082335
108Anencephaly (HP:0002323)1.74053572
109Cutaneous finger syndactyly (HP:0010554)1.73341977
110Renal duplication (HP:0000075)1.73101261
111Subacute progressive viral hepatitis (HP:0006572)1.72759536
112Embryonal renal neoplasm (HP:0011794)1.72733093
113Preaxial hand polydactyly (HP:0001177)1.72682426
114Absent forearm bone (HP:0003953)1.72523534
115Aplasia involving forearm bones (HP:0009822)1.72523534
116Long clavicles (HP:0000890)1.72018420
117Abnormality of the labia majora (HP:0012881)1.71226295
118Increased nuchal translucency (HP:0010880)1.71225916
119Hypoplastic labia majora (HP:0000059)1.71146998
120Anophthalmia (HP:0000528)1.71035436
121Narrow forehead (HP:0000341)1.70984587
122Poor coordination (HP:0002370)1.70948450
123Visual hallucinations (HP:0002367)1.70666362
124Asymmetry of the thorax (HP:0001555)1.70446035
125Patellar aplasia (HP:0006443)1.70297462
126Methylmalonic acidemia (HP:0002912)1.70152446
127Congenital primary aphakia (HP:0007707)1.70022660
128Transitional cell carcinoma of the bladder (HP:0006740)1.69988768
129Abnormality of the musculature of the pelvis (HP:0001469)1.68744336
130Abnormality of the hip-girdle musculature (HP:0001445)1.68744336
131Specific learning disability (HP:0001328)1.68163856
132Micropenis (HP:0000054)1.68076319
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.66963419
134Skull defect (HP:0001362)1.65915019
135Narrow palate (HP:0000189)1.65490702
136Rib fusion (HP:0000902)1.65322496
137Sacral dimple (HP:0000960)1.63900867
138Postaxial foot polydactyly (HP:0001830)1.63882572
139Tubulointerstitial nephritis (HP:0001970)1.63795083
140Shallow orbits (HP:0000586)1.63315638
141Short 1st metacarpal (HP:0010034)1.63035458
142Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63035458
143Sclerocornea (HP:0000647)1.62951140
144Shawl scrotum (HP:0000049)1.62238694
145Abnormality of the preputium (HP:0100587)1.62009303
146Truncal ataxia (HP:0002078)1.61860075
147Genetic anticipation (HP:0003743)1.61166810
148Lissencephaly (HP:0001339)1.60523798
149Hip dysplasia (HP:0001385)1.59911057
150Abnormal lung lobation (HP:0002101)1.59827619
151Nephrogenic diabetes insipidus (HP:0009806)1.59429131
152Generalized hypopigmentation of hair (HP:0011358)1.57448174
153Omphalocele (HP:0001539)1.57304181
154Febrile seizures (HP:0002373)1.56995433
155Birth length less than 3rd percentile (HP:0003561)1.56511377
156Hyperventilation (HP:0002883)1.55951071
157Renal hypoplasia (HP:0000089)1.55943132
158Postaxial hand polydactyly (HP:0001162)1.55764736
159Short foot (HP:0001773)1.55219621
160Gastrointestinal atresia (HP:0002589)1.55064175
161Broad thumb (HP:0011304)1.54988057
162Cystic liver disease (HP:0006706)1.54831586
163Cutaneous syndactyly (HP:0012725)1.54582175
164Hypoplasia of the fovea (HP:0007750)1.54544355
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.54544355
166Ependymoma (HP:0002888)1.53914027
167Genital tract atresia (HP:0001827)1.53900906
168Germ cell neoplasia (HP:0100728)1.53662296
169Aplasia/Hypoplasia of the patella (HP:0006498)1.52659429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.27307000
2WNK33.14557123
3MARK13.03757477
4NTRK33.00855084
5PNCK2.66850315
6SRPK12.47305819
7TNIK2.44634635
8PLK42.43655201
9MKNK22.32037576
10MKNK12.28788357
11CASK2.22914445
12NUAK12.19874901
13TRIM282.15368132
14BMPR1B2.15096710
15SCYL22.12708442
16PLK31.87540649
17KSR11.79738744
18ERBB31.79285041
19MAP3K41.77960901
20MAP4K21.77494671
21MAPK131.74409693
22BRSK21.70316702
23BRD41.67499282
24BUB11.64735935
25TAF11.63304682
26STK38L1.62125695
27ACVR1B1.61257755
28PLK21.61202835
29EPHA41.51315464
30EIF2AK31.47586713
31LATS11.45668809
32MINK11.44282973
33CDK121.35315827
34FGFR21.32350689
35WEE11.28965865
36PASK1.28176863
37CSNK1G21.27921640
38NTRK21.24048672
39MAP2K71.23340184
40SGK21.22962422
41ALK1.22332737
42FRK1.19974505
43SIK21.11838465
44CAMK1G1.09659947
45YES11.09422092
46CSNK1G31.07211357
47STK391.06560051
48PRPF4B1.04246077
49CAMK1D1.02475059
50CSNK1A1L1.01089228
51PAK60.97899718
52RET0.97656946
53STK30.97652865
54EIF2AK10.97409119
55GRK10.96924342
56TGFBR10.96195245
57PBK0.95409547
58MELK0.94769713
59LATS20.93265188
60DYRK1A0.93133913
61ATM0.92628001
62SGK30.91694536
63CSNK1D0.90363146
64MST40.90289630
65NEK60.89457532
66AKT30.88953945
67WNK40.88660274
68NEK10.88080068
69ZAK0.87887992
70CHEK10.86391081
71INSRR0.84685421
72MAP3K90.84634898
73CSNK1G10.83727085
74TYRO30.83216124
75MAP3K20.80809338
76ADRBK20.80471461
77ATR0.79417428
78CHEK20.79417262
79PKN20.79258960
80OXSR10.78524096
81UHMK10.78405277
82RPS6KB10.76527070
83CDK20.76414177
84MAPK100.76171078
85CDK10.75186631
86MAP2K40.75075662
87CSNK1E0.74602092
88CDK50.74389683
89SGK4940.73725421
90SGK2230.73725421
91CDK60.73636210
92SGK10.72706297
93PLK10.71626805
94NEK20.71246709
95TTK0.70420364
96NLK0.69709538
97FGFR10.69297492
98DYRK30.67610082
99WNK10.64131976
100CDK30.64041581
101DYRK20.62297900
102GSK3B0.61469022
103MAPK140.59396852
104PRKCG0.59084205
105PDGFRA0.58878408
106NTRK10.58045253
107VRK20.57179082
108PRKDC0.57037938
109STK160.56871478
110PRKCH0.55530304
111FER0.55145649
112CDK90.53979354
113MAPK80.51503747
114PAK30.51078499
115EIF2AK20.50964806
116PHKG10.50696438
117PHKG20.50696438
118BCR0.50432461
119MAP3K60.50291444
120CAMKK10.49518562
121PINK10.49469540
122PRKCE0.48925938
123KSR20.48816647
124TSSK60.48691656
125CDK140.46520391
126DMPK0.46014109
127RPS6KA30.45939425
128NME10.45894434
129FGR0.45785527
130VRK10.45661681
131BRSK10.44914184
132AURKB0.43421980
133CDK180.41344385
134MAP3K100.40116957
135PDK20.39580401
136STK110.35873787
137CSNK2A20.33456032

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.89607204
2Nicotine addiction_Homo sapiens_hsa050332.48677657
3Long-term potentiation_Homo sapiens_hsa047202.47301329
4RNA polymerase_Homo sapiens_hsa030202.42015992
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29667767
6mRNA surveillance pathway_Homo sapiens_hsa030152.05287316
7Amphetamine addiction_Homo sapiens_hsa050311.95097695
8Dopaminergic synapse_Homo sapiens_hsa047281.92250638
9Alcoholism_Homo sapiens_hsa050341.90244087
10Glutamatergic synapse_Homo sapiens_hsa047241.89647058
11Selenocompound metabolism_Homo sapiens_hsa004501.87894045
12Propanoate metabolism_Homo sapiens_hsa006401.86754380
13Oocyte meiosis_Homo sapiens_hsa041141.84676648
14Circadian entrainment_Homo sapiens_hsa047131.79518906
15Olfactory transduction_Homo sapiens_hsa047401.70237432
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69622451
17RNA transport_Homo sapiens_hsa030131.69007145
18Axon guidance_Homo sapiens_hsa043601.62532549
19Cell cycle_Homo sapiens_hsa041101.60748675
20Long-term depression_Homo sapiens_hsa047301.59875059
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59865273
22GABAergic synapse_Homo sapiens_hsa047271.58823005
23Proteasome_Homo sapiens_hsa030501.56998023
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55869295
25Steroid biosynthesis_Homo sapiens_hsa001001.55018995
26Morphine addiction_Homo sapiens_hsa050321.53959584
27Systemic lupus erythematosus_Homo sapiens_hsa053221.50726904
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49189051
29Glioma_Homo sapiens_hsa052141.45179338
30Spliceosome_Homo sapiens_hsa030401.44870367
31Colorectal cancer_Homo sapiens_hsa052101.42079295
32Oxidative phosphorylation_Homo sapiens_hsa001901.39716957
33Cholinergic synapse_Homo sapiens_hsa047251.37333706
34Endometrial cancer_Homo sapiens_hsa052131.36401309
35Ribosome_Homo sapiens_hsa030101.35541352
36Cocaine addiction_Homo sapiens_hsa050301.34607247
37Wnt signaling pathway_Homo sapiens_hsa043101.33414774
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33264349
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33132782
40Parkinsons disease_Homo sapiens_hsa050121.31991553
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31741122
42Gap junction_Homo sapiens_hsa045401.27191869
43Synaptic vesicle cycle_Homo sapiens_hsa047211.27030783
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.25489707
45Serotonergic synapse_Homo sapiens_hsa047261.25250321
46Huntingtons disease_Homo sapiens_hsa050161.24166993
47MicroRNAs in cancer_Homo sapiens_hsa052061.23096050
48Taste transduction_Homo sapiens_hsa047421.22084973
49Hippo signaling pathway_Homo sapiens_hsa043901.22039877
50Melanogenesis_Homo sapiens_hsa049161.20502647
51Non-small cell lung cancer_Homo sapiens_hsa052231.17312088
52mTOR signaling pathway_Homo sapiens_hsa041501.16402206
53ErbB signaling pathway_Homo sapiens_hsa040121.14135866
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13995095
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13891204
56* RNA degradation_Homo sapiens_hsa030181.13820546
57Mismatch repair_Homo sapiens_hsa034301.13458535
58Non-homologous end-joining_Homo sapiens_hsa034501.10316008
59Estrogen signaling pathway_Homo sapiens_hsa049151.09868270
60Oxytocin signaling pathway_Homo sapiens_hsa049211.07179782
61Basal cell carcinoma_Homo sapiens_hsa052171.06194873
62Renin secretion_Homo sapiens_hsa049241.06022971
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04543336
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04007622
65Butanoate metabolism_Homo sapiens_hsa006501.03605861
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02918108
67Fanconi anemia pathway_Homo sapiens_hsa034601.02687751
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02521226
69One carbon pool by folate_Homo sapiens_hsa006701.02028221
70Dorso-ventral axis formation_Homo sapiens_hsa043201.01627509
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.99401574
72TGF-beta signaling pathway_Homo sapiens_hsa043500.99029871
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97959086
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97836397
75Prostate cancer_Homo sapiens_hsa052150.95922498
76Thyroid cancer_Homo sapiens_hsa052160.95535820
77Insulin secretion_Homo sapiens_hsa049110.95098342
78Purine metabolism_Homo sapiens_hsa002300.93111588
79Hedgehog signaling pathway_Homo sapiens_hsa043400.92927292
80Nucleotide excision repair_Homo sapiens_hsa034200.92191627
81p53 signaling pathway_Homo sapiens_hsa041150.91858671
82Renal cell carcinoma_Homo sapiens_hsa052110.91451429
83Phototransduction_Homo sapiens_hsa047440.91442123
84Base excision repair_Homo sapiens_hsa034100.91030622
85GnRH signaling pathway_Homo sapiens_hsa049120.89914327
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89806840
87Viral carcinogenesis_Homo sapiens_hsa052030.88746571
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88060089
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87481881
90Melanoma_Homo sapiens_hsa052180.86480206
91Salivary secretion_Homo sapiens_hsa049700.86346065
92Circadian rhythm_Homo sapiens_hsa047100.84423631
93DNA replication_Homo sapiens_hsa030300.83539836
94Adherens junction_Homo sapiens_hsa045200.83237690
95Chronic myeloid leukemia_Homo sapiens_hsa052200.82122923
96Cardiac muscle contraction_Homo sapiens_hsa042600.81599293
97Alzheimers disease_Homo sapiens_hsa050100.80495249
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80467487
99cAMP signaling pathway_Homo sapiens_hsa040240.77857552
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77706817
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.77214946
102MAPK signaling pathway_Homo sapiens_hsa040100.76620726
103Glucagon signaling pathway_Homo sapiens_hsa049220.75091849
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73038305
105Proteoglycans in cancer_Homo sapiens_hsa052050.72821849
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72518161
107Type II diabetes mellitus_Homo sapiens_hsa049300.72507701
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72368645
109Tight junction_Homo sapiens_hsa045300.71859277
110Gastric acid secretion_Homo sapiens_hsa049710.71778681
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.71707188
112Choline metabolism in cancer_Homo sapiens_hsa052310.70989466
113Pyrimidine metabolism_Homo sapiens_hsa002400.69853190
114Calcium signaling pathway_Homo sapiens_hsa040200.69382615
115Lysine degradation_Homo sapiens_hsa003100.68043344
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67547404
117Rap1 signaling pathway_Homo sapiens_hsa040150.66841942
118Pyruvate metabolism_Homo sapiens_hsa006200.65639690
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65364674
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63935566
121Basal transcription factors_Homo sapiens_hsa030220.61672164
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60297021
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59776701
124Ether lipid metabolism_Homo sapiens_hsa005650.58277927
125Thyroid hormone synthesis_Homo sapiens_hsa049180.57566898
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57134477
127Pathways in cancer_Homo sapiens_hsa052000.57111816
128Homologous recombination_Homo sapiens_hsa034400.56304994
129HTLV-I infection_Homo sapiens_hsa051660.55270617
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54007560
131Linoleic acid metabolism_Homo sapiens_hsa005910.53887680
132Ras signaling pathway_Homo sapiens_hsa040140.52957981
133Nitrogen metabolism_Homo sapiens_hsa009100.52805798
134FoxO signaling pathway_Homo sapiens_hsa040680.52789630
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.52485670
136Vitamin B6 metabolism_Homo sapiens_hsa007500.48787915
137Caffeine metabolism_Homo sapiens_hsa002320.45439095
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44265382
139Fatty acid biosynthesis_Homo sapiens_hsa000610.40176096
140Regulation of autophagy_Homo sapiens_hsa041400.39711888
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37937228
142Metabolic pathways_Homo sapiens_hsa011000.36498564
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34272993
144Tryptophan metabolism_Homo sapiens_hsa003800.32993589
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27422761
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27085373

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