DHX37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)4.52463739
2mitotic chromosome condensation (GO:0007076)4.50544407
3DNA unwinding involved in DNA replication (GO:0006268)4.34419872
4spliceosomal tri-snRNP complex assembly (GO:0000244)4.22644883
5IMP metabolic process (GO:0046040)3.90181305
6protein complex localization (GO:0031503)3.82731390
7peptidyl-arginine omega-N-methylation (GO:0035247)3.80143922
8regulation of translational termination (GO:0006449)3.77989081
9folic acid-containing compound biosynthetic process (GO:0009396)3.75768587
10DNA replication initiation (GO:0006270)3.75674201
11telomere maintenance via semi-conservative replication (GO:0032201)3.75084767
12nucleobase biosynthetic process (GO:0046112)3.74574679
13cellular protein complex localization (GO:0034629)3.70490180
14proline biosynthetic process (GO:0006561)3.69336886
15DNA strand elongation involved in DNA replication (GO:0006271)3.69139323
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.67825487
17protein localization to kinetochore (GO:0034501)3.65692284
18maturation of SSU-rRNA (GO:0030490)3.60303955
19ribosome biogenesis (GO:0042254)3.59646256
20ribosomal small subunit assembly (GO:0000028)3.56744924
21DNA strand elongation (GO:0022616)3.56251139
22mitotic nuclear envelope disassembly (GO:0007077)3.49091280
23nuclear pore organization (GO:0006999)3.48806435
24nuclear pore complex assembly (GO:0051292)3.46858222
25Golgi transport vesicle coating (GO:0048200)3.46726457
26COPI coating of Golgi vesicle (GO:0048205)3.46726457
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38987291
28activation of Rac GTPase activity (GO:0032863)3.37055326
29apoptotic process involved in morphogenesis (GO:0060561)3.36251602
30snRNA processing (GO:0016180)3.36013087
31tRNA methylation (GO:0030488)3.31553988
32telomere maintenance via recombination (GO:0000722)3.31300084
33mRNA stabilization (GO:0048255)3.27757989
34RNA stabilization (GO:0043489)3.27757989
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.25942325
36regulation of RNA export from nucleus (GO:0046831)3.25791408
37ribonucleoprotein complex biogenesis (GO:0022613)3.25773667
38protein localization to chromosome, centromeric region (GO:0071459)3.24628058
39mitotic recombination (GO:0006312)3.20513388
40DNA duplex unwinding (GO:0032508)3.20487934
41snRNA metabolic process (GO:0016073)3.20067139
42histone arginine methylation (GO:0034969)3.18671866
43DNA geometric change (GO:0032392)3.16318574
44DNA replication checkpoint (GO:0000076)3.12990892
45formation of translation preinitiation complex (GO:0001731)3.12681884
46rRNA transcription (GO:0009303)3.12312412
47telomere maintenance via telomere lengthening (GO:0010833)3.11289101
48dosage compensation (GO:0007549)3.11274980
49membrane disassembly (GO:0030397)3.11235101
50nuclear envelope disassembly (GO:0051081)3.11235101
51negative regulation of mRNA processing (GO:0050686)3.09000424
52purine nucleobase biosynthetic process (GO:0009113)3.08815320
53ribosomal large subunit biogenesis (GO:0042273)3.08309277
54negative regulation of RNA splicing (GO:0033119)3.07657291
55peptidyl-arginine N-methylation (GO:0035246)3.06698143
56peptidyl-arginine methylation (GO:0018216)3.06698143
57histone H4-K12 acetylation (GO:0043983)3.02331945
58adherens junction assembly (GO:0034333)2.98940369
59cell-substrate adherens junction assembly (GO:0007045)2.98486763
60focal adhesion assembly (GO:0048041)2.98486763
61regulation of gene silencing by RNA (GO:0060966)2.98305838
62regulation of posttranscriptional gene silencing (GO:0060147)2.98305838
63regulation of gene silencing by miRNA (GO:0060964)2.98305838
64mitotic metaphase plate congression (GO:0007080)2.96711108
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95587072
66DNA deamination (GO:0045006)2.94877272
67regulation of nucleobase-containing compound transport (GO:0032239)2.94670807
68regulation of translational fidelity (GO:0006450)2.93885889
69pore complex assembly (GO:0046931)2.92457039
70pentose-phosphate shunt (GO:0006098)2.92377883
71chromosome condensation (GO:0030261)2.91643694
72regulation of histone H3-K27 methylation (GO:0061085)2.90106445
73protein-DNA complex disassembly (GO:0032986)2.89233680
74nucleosome disassembly (GO:0006337)2.89233680
75protein export from nucleus (GO:0006611)2.86726040
76negative regulation of cell size (GO:0045792)2.83929198
77folic acid metabolic process (GO:0046655)2.83894400
78intracellular estrogen receptor signaling pathway (GO:0030520)2.82685538
79mitotic sister chromatid segregation (GO:0000070)2.82527249
80regulation of histone H3-K9 methylation (GO:0051570)2.81076604
81rRNA processing (GO:0006364)2.80752709
82protein localization to endosome (GO:0036010)2.79055889
83DNA replication-dependent nucleosome assembly (GO:0006335)2.78907671
84DNA replication-dependent nucleosome organization (GO:0034723)2.78907671
85regulation of NFAT protein import into nucleus (GO:0051532)2.77628544
86ribosomal small subunit biogenesis (GO:0042274)2.76804471
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.76523970
88negative regulation of erythrocyte differentiation (GO:0045647)2.76073827
89positive regulation of chromosome segregation (GO:0051984)2.75930161
90kinetochore organization (GO:0051383)2.75921632
91RNA splicing, via transesterification reactions (GO:0000375)2.75582191
92meiotic chromosome segregation (GO:0045132)2.74401794
93regulation of chromatin binding (GO:0035561)2.74333399
94metaphase plate congression (GO:0051310)2.74251857
95mitotic sister chromatid cohesion (GO:0007064)2.73568751
96rRNA metabolic process (GO:0016072)2.73238763
97negative regulation of mRNA metabolic process (GO:1903312)2.72809622
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72797548
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72757064
100mRNA splicing, via spliceosome (GO:0000398)2.72757064
101DNA topological change (GO:0006265)2.70573908
102chromatin assembly (GO:0031497)2.70113780
103embryonic process involved in female pregnancy (GO:0060136)2.69994548
104heterochromatin organization (GO:0070828)2.66313348
105pinocytosis (GO:0006907)2.65611143
106viral transcription (GO:0019083)2.65089250
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64204233
108histone H2A acetylation (GO:0043968)2.64031113
109termination of RNA polymerase II transcription (GO:0006369)2.61496167
110translational termination (GO:0006415)2.61165685
111pseudouridine synthesis (GO:0001522)2.60505381
112sister chromatid segregation (GO:0000819)2.60502907
113telomere maintenance (GO:0000723)2.60275377
114telomere organization (GO:0032200)2.59434320
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58965316
116mitochondrial fusion (GO:0008053)2.58827768
117base-excision repair (GO:0006284)2.58502132
118mitochondrial DNA metabolic process (GO:0032042)2.58168963
119tRNA modification (GO:0006400)2.57657451
120regulation of gene silencing (GO:0060968)2.57262131
121nucleobase-containing small molecule interconversion (GO:0015949)2.56560404
122protein K6-linked ubiquitination (GO:0085020)2.56422842
123kinetochore assembly (GO:0051382)2.56277869
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.56206621
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56206621
126ribosome assembly (GO:0042255)2.55898597
127pre-miRNA processing (GO:0031054)2.54911400
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.54411611
129viral mRNA export from host cell nucleus (GO:0046784)2.53080627
130DNA synthesis involved in DNA repair (GO:0000731)2.52233922
131spliceosomal snRNP assembly (GO:0000387)2.52174865
132negative regulation of viral release from host cell (GO:1902187)2.50911201
133mitotic G1 DNA damage checkpoint (GO:0031571)2.50695482
1343-UTR-mediated mRNA stabilization (GO:0070935)2.50551929
135glucocorticoid receptor signaling pathway (GO:0042921)2.49855471
136DNA replication (GO:0006260)2.49842511
137NIK/NF-kappaB signaling (GO:0038061)2.49790891
138glucose catabolic process (GO:0006007)2.48884549
139nuclear envelope reassembly (GO:0031468)2.48583543
140mitotic nuclear envelope reassembly (GO:0007084)2.48583543
141translational initiation (GO:0006413)2.48530141
142mismatch repair (GO:0006298)2.48193719
143mRNA export from nucleus (GO:0006406)2.47947931
144RNA export from nucleus (GO:0006405)2.47867394
145maturation of 5.8S rRNA (GO:0000460)2.47656040
146DNA-templated transcription, termination (GO:0006353)2.47429287
147establishment of chromosome localization (GO:0051303)2.46956619
148positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.46861595
149ncRNA 3-end processing (GO:0043628)2.45926575
150DNA conformation change (GO:0071103)2.45299093
151translesion synthesis (GO:0019985)2.45286953
152DNA packaging (GO:0006323)2.44825905
153negative regulation of histone methylation (GO:0031061)2.44762892
154NADPH regeneration (GO:0006740)2.44541895
155mRNA transport (GO:0051028)2.44489098
156maternal placenta development (GO:0001893)2.43774311
157positive regulation of DNA-dependent DNA replication (GO:2000105)2.43763093
158nuclear envelope organization (GO:0006998)2.43621952
159proteasome assembly (GO:0043248)2.43505437
160ncRNA processing (GO:0034470)2.43403537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59257402
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.88936613
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49586758
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.45457864
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13473191
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92709244
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81964228
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.63773506
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59239572
10MYC_22102868_ChIP-Seq_BL_Human2.56997300
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46324606
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.34241322
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33812302
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18356640
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.18298924
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14793245
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14579901
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.11356471
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.06776137
20CIITA_25753668_ChIP-Seq_RAJI_Human2.05605417
21XRN2_22483619_ChIP-Seq_HELA_Human1.99821878
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97900085
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.96007220
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94689206
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94471041
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92616949
27VDR_23849224_ChIP-Seq_CD4+_Human1.88432901
28FOXP3_21729870_ChIP-Seq_TREG_Human1.86931260
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.85544363
30LXR_22292898_ChIP-Seq_THP-1_Human1.83635748
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.82323412
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81397927
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.80740526
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78530599
35ZNF263_19887448_ChIP-Seq_K562_Human1.77276482
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74195129
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70692997
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70094714
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69509572
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68601590
41VDR_21846776_ChIP-Seq_THP-1_Human1.66297611
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64205119
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63980702
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63646606
45RACK7_27058665_Chip-Seq_MCF-7_Human1.62868079
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61769856
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60735592
48TTF2_22483619_ChIP-Seq_HELA_Human1.60697086
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59596742
50DCP1A_22483619_ChIP-Seq_HELA_Human1.58642444
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55719547
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55510352
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54062335
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52902450
55KDM2B_26808549_Chip-Seq_DND41_Human1.51919982
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51198774
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50989287
58GABP_19822575_ChIP-Seq_HepG2_Human1.47496721
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43405908
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41793870
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40844693
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.38601323
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36673685
64KDM5A_27292631_Chip-Seq_BREAST_Human1.34127499
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33978330
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32761628
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31553076
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29693802
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29042683
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28528103
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27687460
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.25969312
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25772598
74VDR_24763502_ChIP-Seq_THP-1_Human1.25356234
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24179106
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23547667
77ELK1_19687146_ChIP-ChIP_HELA_Human1.23533496
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22729702
79AR_21909140_ChIP-Seq_LNCAP_Human1.22302766
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22208516
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21454767
82ATF3_27146783_Chip-Seq_COLON_Human1.20416564
83SCL_19346495_ChIP-Seq_HPC-7_Human1.19473091
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19387495
85SPI1_23547873_ChIP-Seq_NB4_Human1.18834500
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18602930
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18313609
88* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16934693
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16925006
90NCOR1_26117541_ChIP-Seq_K562_Human1.16784305
91MYB_26560356_Chip-Seq_TH1_Human1.16421529
92P68_20966046_ChIP-Seq_HELA_Human1.16250575
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15206350
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15117840
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13224475
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13019048
97MAF_26560356_Chip-Seq_TH1_Human1.12546824
98TFEB_21752829_ChIP-Seq_HELA_Human1.11449937
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11103523
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10370814
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10267600
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09618974
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09450761
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08871725
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07643497
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07278832
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07063470
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06195559
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05695262
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.04449911
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04422177
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03934255
113MYB_26560356_Chip-Seq_TH2_Human1.03832908
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03028428
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02789502
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02595169
117UTX_26944678_Chip-Seq_JUKART_Human1.01854336
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01580789
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.01078601
120TCF7_22412390_ChIP-Seq_EML_Mouse1.00986889
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.00954638
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.00828530
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99901232
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99471139
125CLOCK_20551151_ChIP-Seq_293T_Human0.99461974
126KDM2B_26808549_Chip-Seq_K562_Human0.99317867
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98286103
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.97506616
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97382248
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97382220
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97348086
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97313044
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97313044
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97313044
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96010065
136MAF_26560356_Chip-Seq_TH2_Human0.94831092
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94435869
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93280442
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92125236
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90403712
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89015271
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87920842
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86070599
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85758114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.93368433
2MP0003111_abnormal_nucleus_morphology3.82400111
3MP0010094_abnormal_chromosome_stability3.74769028
4MP0003693_abnormal_embryo_hatching3.26402490
5MP0003705_abnormal_hypodermis_morpholog3.18511594
6MP0002396_abnormal_hematopoietic_system3.07495378
7MP0003077_abnormal_cell_cycle3.02054610
8MP0005451_abnormal_body_composition3.01552338
9MP0004957_abnormal_blastocyst_morpholog2.77255141
10MP0008058_abnormal_DNA_repair2.73592741
11MP0008007_abnormal_cellular_replicative2.66090472
12MP0004185_abnormal_adipocyte_glucose2.41099703
13MP0004233_abnormal_muscle_weight2.25732823
14MP0010234_abnormal_vibrissa_follicle2.14891673
15MP0003763_abnormal_thymus_physiology2.09110776
16MP0008877_abnormal_DNA_methylation1.89851647
17MP0001849_ear_inflammation1.88993649
18MP0000490_abnormal_crypts_of1.88649735
19MP0004808_abnormal_hematopoietic_stem1.81989759
20MP0001348_abnormal_lacrimal_gland1.78936115
21MP0000350_abnormal_cell_proliferation1.76364841
22MP0010352_gastrointestinal_tract_polyps1.73451199
23MP0009333_abnormal_splenocyte_physiolog1.70248351
24MP0003786_premature_aging1.69950211
25MP0008932_abnormal_embryonic_tissue1.68992968
26MP0008260_abnormal_autophagy1.65493037
27MP0001545_abnormal_hematopoietic_system1.63988853
28MP0005397_hematopoietic_system_phenotyp1.63988853
29MP0001730_embryonic_growth_arrest1.62844902
30MP0002398_abnormal_bone_marrow1.61974462
31MP0001672_abnormal_embryogenesis/_devel1.61052164
32MP0005380_embryogenesis_phenotype1.61052164
33MP0005058_abnormal_lysosome_morphology1.58639770
34MP0006292_abnormal_olfactory_placode1.56883174
35MP0000703_abnormal_thymus_morphology1.52520189
36MP0003984_embryonic_growth_retardation1.52487922
37MP0002132_abnormal_respiratory_system1.50181667
38MP0002796_impaired_skin_barrier1.49449396
39MP0002088_abnormal_embryonic_growth/wei1.48579672
40MP0002254_reproductive_system_inflammat1.47348021
41MP0009840_abnormal_foam_cell1.42456089
42MP0000689_abnormal_spleen_morphology1.42224743
43MP0005501_abnormal_skin_physiology1.41976524
44MP0010307_abnormal_tumor_latency1.41035226
45MP0004197_abnormal_fetal_growth/weight/1.40425584
46MP0000313_abnormal_cell_death1.40214095
47MP0009278_abnormal_bone_marrow1.39529422
48MP0000537_abnormal_urethra_morphology1.39481682
49MP0002722_abnormal_immune_system1.38912805
50MP0009672_abnormal_birth_weight1.37779741
51MP0001661_extended_life_span1.37714575
52MP0001800_abnormal_humoral_immune1.36463572
53MP0001697_abnormal_embryo_size1.33497759
54MP0000685_abnormal_immune_system1.29490672
55MP0003091_abnormal_cell_migration1.29397570
56MP0002019_abnormal_tumor_incidence1.29084496
57MP0005076_abnormal_cell_differentiation1.29023788
58MP0002086_abnormal_extraembryonic_tissu1.28454376
59MP0000003_abnormal_adipose_tissue1.26464297
60MP0003303_peritoneal_inflammation1.25138742
61MP0005075_abnormal_melanosome_morpholog1.24788960
62MP0002429_abnormal_blood_cell1.24582806
63MP0002080_prenatal_lethality1.24448842
64MP0010030_abnormal_orbit_morphology1.23446074
65MP0005671_abnormal_response_to1.23407196
66MP0004947_skin_inflammation1.22688468
67MP0000716_abnormal_immune_system1.22099054
68MP0005621_abnormal_cell_physiology1.22042750
69MP0002085_abnormal_embryonic_tissue1.21891229
70MP0000678_abnormal_parathyroid_gland1.20099104
71MP0003890_abnormal_embryonic-extraembry1.19290794
72MP0001835_abnormal_antigen_presentation1.19112169
73MP0005666_abnormal_adipose_tissue1.17610113
74MP0002060_abnormal_skin_morphology1.16892076
75MP0000858_altered_metastatic_potential1.15959410
76MP0005174_abnormal_tail_pigmentation1.15906781
77MP0002452_abnormal_antigen_presenting1.15847557
78MP0002405_respiratory_system_inflammati1.13506266
79MP0003300_gastrointestinal_ulcer1.13488272
80MP0001790_abnormal_immune_system1.12921110
81MP0005387_immune_system_phenotype1.12921110
82MP0002420_abnormal_adaptive_immunity1.12654757
83MP0003567_abnormal_fetal_cardiomyocyte1.12168250
84MP0005623_abnormal_meninges_morphology1.11216428
85MP0002084_abnormal_developmental_patter1.10642216
86MP0001819_abnormal_immune_cell1.10576846
87MP0001293_anophthalmia1.10230293
88MP0002009_preneoplasia1.08783471
89MP0005375_adipose_tissue_phenotype1.07652166
90MP0002089_abnormal_postnatal_growth/wei1.06149750
91MP0004381_abnormal_hair_follicle1.05063940
92MP0002723_abnormal_immune_serum1.04425018
93MP0010155_abnormal_intestine_physiology1.01024255
94MP0003172_abnormal_lysosome_physiology1.00996237
95MP0003436_decreased_susceptibility_to0.99787412
96MP0001216_abnormal_epidermal_layer0.98539653
97MP0004858_abnormal_nervous_system0.98201683
98MP0008789_abnormal_olfactory_epithelium0.97450800
99MP0002166_altered_tumor_susceptibility0.97420650
100MP0005384_cellular_phenotype0.97047602
101MP0001853_heart_inflammation0.94353243
102MP0003566_abnormal_cell_adhesion0.93078967
103MP0000371_diluted_coat_color0.92944804
104MP0003787_abnormal_imprinting0.91927018
105MP0003221_abnormal_cardiomyocyte_apopto0.91377746
106MP0001915_intracranial_hemorrhage0.90363285
107MP0004264_abnormal_extraembryonic_tissu0.89890519
108MP0004133_heterotaxia0.89827510
109MP0009931_abnormal_skin_appearance0.87430256
110MP0005257_abnormal_intraocular_pressure0.86800411
111MP0003121_genomic_imprinting0.86785823
112MP0003941_abnormal_skin_development0.86784845
113MP0002075_abnormal_coat/hair_pigmentati0.86388933
114MP0000015_abnormal_ear_pigmentation0.85246035
115MP0008438_abnormal_cutaneous_collagen0.85244190
116MP0001873_stomach_inflammation0.84321455
117MP0000358_abnormal_cell_content/0.82945467
118MP0002877_abnormal_melanocyte_morpholog0.80500179
119MP0005000_abnormal_immune_tolerance0.79174545
120MP0000747_muscle_weakness0.79120180
121MP0005025_abnormal_response_to0.78475642
122MP0005670_abnormal_white_adipose0.77908937
123MP0001286_abnormal_eye_development0.77136756
124MP0002970_abnormal_white_adipose0.76876291
125MP0002697_abnormal_eye_size0.76494963
126MP0001186_pigmentation_phenotype0.76456288
127MP0002210_abnormal_sex_determination0.75863705
128MP0002092_abnormal_eye_morphology0.75395718
129MP0002933_joint_inflammation0.74885278
130MP0000759_abnormal_skeletal_muscle0.74673172
131MP0005023_abnormal_wound_healing0.74537755
132MP0001346_abnormal_lacrimal_gland0.73686111
133MP0002006_tumorigenesis0.73500048
134MP0003279_aneurysm0.73125317
135MP0002111_abnormal_tail_morphology0.70021474
136MP0000432_abnormal_head_morphology0.69781566
137MP0000465_gastrointestinal_hemorrhage0.69465912
138MP0005310_abnormal_salivary_gland0.69027470
139MP0000733_abnormal_muscle_development0.68699333
140MP0010630_abnormal_cardiac_muscle0.68628419
141MP0003123_paternal_imprinting0.68101694
142MP0005464_abnormal_platelet_physiology0.67929762
143MP0003448_altered_tumor_morphology0.67696555
144MP0003718_maternal_effect0.67459736
145MP0006035_abnormal_mitochondrial_morpho0.67180332
146MP0000477_abnormal_intestine_morphology0.65537861
147MP0003453_abnormal_keratinocyte_physiol0.64003640
148MP0003136_yellow_coat_color0.63429457

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.86531655
2Chromsome breakage (HP:0040012)4.54279059
3Hyperacusis (HP:0010780)4.01617373
4Reticulocytopenia (HP:0001896)3.92233406
5Ectopic kidney (HP:0000086)3.39996326
6Progressive muscle weakness (HP:0003323)3.37368268
7Duplicated collecting system (HP:0000081)3.27667771
811 pairs of ribs (HP:0000878)3.24359155
9Selective tooth agenesis (HP:0001592)3.08594514
10Absent thumb (HP:0009777)2.99616707
11Distal lower limb amyotrophy (HP:0008944)2.89209894
12Meckel diverticulum (HP:0002245)2.89198834
13Abnormality of the preputium (HP:0100587)2.88738368
14Ulnar bowing (HP:0003031)2.87285369
15Myelodysplasia (HP:0002863)2.87018963
16Abnormality of the ileum (HP:0001549)2.86471991
17Trismus (HP:0000211)2.78134605
18Abnormality of the renal collecting system (HP:0004742)2.76566906
19Achilles tendon contracture (HP:0001771)2.76016842
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.74363992
21Panhypogammaglobulinemia (HP:0003139)2.72277532
22Abnormality of chromosome stability (HP:0003220)2.70756926
23Patellar aplasia (HP:0006443)2.70636042
24Microvesicular hepatic steatosis (HP:0001414)2.65837753
25Insomnia (HP:0100785)2.64824983
26Birth length less than 3rd percentile (HP:0003561)2.64707965
27Long palpebral fissure (HP:0000637)2.60420528
28Ragged-red muscle fibers (HP:0003200)2.60171626
29Abnormality of DNA repair (HP:0003254)2.59213239
30Dysmetric saccades (HP:0000641)2.55135198
31Absent radius (HP:0003974)2.55060079
32Abnormal number of erythroid precursors (HP:0012131)2.54812379
33Missing ribs (HP:0000921)2.54685689
34Progressive external ophthalmoplegia (HP:0000590)2.52774246
35Broad face (HP:0000283)2.48615676
36Abnormality of cells of the erythroid lineage (HP:0012130)2.46281855
37Ependymoma (HP:0002888)2.41699412
38Increased connective tissue (HP:0009025)2.40953603
39Asymmetry of the thorax (HP:0001555)2.40893070
40Abnormal number of incisors (HP:0011064)2.40509804
41Abnormality of the Achilles tendon (HP:0005109)2.40325794
42Aplasia/Hypoplasia of the patella (HP:0006498)2.39632547
43Impulsivity (HP:0100710)2.33534594
44Absent forearm bone (HP:0003953)2.30685227
45Aplasia involving forearm bones (HP:0009822)2.30685227
46Disproportionate tall stature (HP:0001519)2.29369835
47Abnormality of the fingertips (HP:0001211)2.28396280
48Bone marrow hypocellularity (HP:0005528)2.27408830
49Pallor (HP:0000980)2.27024623
50Medulloblastoma (HP:0002885)2.24427881
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.22641692
52Clubbing of toes (HP:0100760)2.21740498
53Lymphoma (HP:0002665)2.20237807
54Premature rupture of membranes (HP:0001788)2.18362137
55Broad distal phalanx of finger (HP:0009836)2.17871146
56Sparse lateral eyebrow (HP:0005338)2.17143774
57Amaurosis fugax (HP:0100576)2.16555803
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.16054050
59Abnormality of the distal phalanges of the toes (HP:0010182)2.12454824
60Thrombocytosis (HP:0001894)2.09162361
61Urethral obstruction (HP:0000796)2.08944388
62Intestinal fistula (HP:0100819)2.08101003
63Agammaglobulinemia (HP:0004432)2.07877575
64Vertebral compression fractures (HP:0002953)2.07768469
65Recurrent viral infections (HP:0004429)2.04525479
66Short thumb (HP:0009778)2.04384165
67Duodenal stenosis (HP:0100867)2.03776795
68Small intestinal stenosis (HP:0012848)2.03776795
69Breast hypoplasia (HP:0003187)2.03539847
70Distal upper limb amyotrophy (HP:0007149)2.01338579
71Upper limb amyotrophy (HP:0009129)2.01338579
72Asplenia (HP:0001746)2.01106023
73Carpal bone hypoplasia (HP:0001498)2.00229405
74IgM deficiency (HP:0002850)1.99043721
75Degeneration of anterior horn cells (HP:0002398)1.98918875
76Abnormality of the anterior horn cell (HP:0006802)1.98918875
77Elfin facies (HP:0004428)1.98850270
78Agnosia (HP:0010524)1.98396022
79Abnormality of pyrimidine metabolism (HP:0004353)1.97598657
80Abnormality of the thoracic spine (HP:0100711)1.96465448
81Multiple enchondromatosis (HP:0005701)1.96303596
82Ankyloglossia (HP:0010296)1.96202249
83Long eyelashes (HP:0000527)1.96024641
84Abnormality of oral frenula (HP:0000190)1.95153935
85Duplication of thumb phalanx (HP:0009942)1.94673823
86Colon cancer (HP:0003003)1.94187547
87Ureteral duplication (HP:0000073)1.92890182
88Deviation of the thumb (HP:0009603)1.91883237
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.91547704
90Skull defect (HP:0001362)1.91518938
91Supernumerary bones of the axial skeleton (HP:0009144)1.91346666
92Sloping forehead (HP:0000340)1.91172601
93Abnormality of the carotid arteries (HP:0005344)1.90389807
94Lower limb amyotrophy (HP:0007210)1.90089418
95Deep palmar crease (HP:0006191)1.89664695
96Patellar dislocation (HP:0002999)1.89485729
97Proximal placement of thumb (HP:0009623)1.89173411
98Acute myeloid leukemia (HP:0004808)1.88216008
99Premature graying of hair (HP:0002216)1.87268901
100Pointed chin (HP:0000307)1.86561004
101Basal cell carcinoma (HP:0002671)1.86456998
102Fatigue (HP:0012378)1.86441318
103Supernumerary spleens (HP:0009799)1.85860706
104Colitis (HP:0002583)1.85392709
105Premature skin wrinkling (HP:0100678)1.85000360
106Overriding aorta (HP:0002623)1.84629388
107Flat acetabular roof (HP:0003180)1.84485506
108T lymphocytopenia (HP:0005403)1.83782948
109Abnormality of T cells (HP:0002843)1.82523212
110Distal lower limb muscle weakness (HP:0009053)1.81996702
111Optic nerve coloboma (HP:0000588)1.81551879
112Triphalangeal thumb (HP:0001199)1.81498214
113Spinal cord lesions (HP:0100561)1.81131032
114Syringomyelia (HP:0003396)1.81131032
115Recurrent fungal infections (HP:0002841)1.80874135
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.79709151
117Broad palm (HP:0001169)1.78561481
118Abnormality of the duodenum (HP:0002246)1.78198878
119Entropion (HP:0000621)1.77065633
120Generalized amyotrophy (HP:0003700)1.76551801
121Tracheoesophageal fistula (HP:0002575)1.76501598
122Squamous cell carcinoma (HP:0002860)1.76283659
123Micronodular cirrhosis (HP:0001413)1.76257048
124Subacute progressive viral hepatitis (HP:0006572)1.75740168
125Cellulitis (HP:0100658)1.75624838
126Septate vagina (HP:0001153)1.75535300
127Progressive hearing impairment (HP:0001730)1.75123285
128Natal tooth (HP:0000695)1.75113337
129Prominent metopic ridge (HP:0005487)1.74311429
130Supernumerary ribs (HP:0005815)1.73728384
131Abnormality of the intervertebral disk (HP:0005108)1.73627878
132Poikiloderma (HP:0001029)1.73607650
133Leukopenia (HP:0001882)1.73302407
134Renal duplication (HP:0000075)1.72837860
135Rough bone trabeculation (HP:0100670)1.72756123
136Short nail (HP:0001799)1.72728268
137High anterior hairline (HP:0009890)1.72435349
138Cutis marmorata (HP:0000965)1.72028677
139Dislocated radial head (HP:0003083)1.71761264
140Back pain (HP:0003418)1.71474889
141Abnormality of T cell physiology (HP:0011840)1.71370886
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71119362
143Difficulty climbing stairs (HP:0003551)1.70732921
144Elevated erythrocyte sedimentation rate (HP:0003565)1.70349867
145Rectal fistula (HP:0100590)1.70118003
146Rectovaginal fistula (HP:0000143)1.70118003
147Viral hepatitis (HP:0006562)1.70080099
148Abnormality of reticulocytes (HP:0004312)1.69795158
149Horseshoe kidney (HP:0000085)1.69137831
150Rhabdomyosarcoma (HP:0002859)1.68409313
151Protrusio acetabuli (HP:0003179)1.68143347
152Elbow flexion contracture (HP:0002987)1.67702728
153Reticulocytosis (HP:0001923)1.66209673
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66117841
155Short 4th metacarpal (HP:0010044)1.66117841
156Prominent nose (HP:0000448)1.65774859
157Nonimmune hydrops fetalis (HP:0001790)1.65203318
158Advanced eruption of teeth (HP:0006288)1.65033664
159IgA deficiency (HP:0002720)1.65015485
160Abnormality of the umbilical cord (HP:0010881)1.64956882
161Abnormal gallbladder physiology (HP:0012438)1.64887616
162Cholecystitis (HP:0001082)1.64887616
163Increased nuchal translucency (HP:0010880)1.63492008
164Biconcave vertebral bodies (HP:0004586)1.63026641
165Volvulus (HP:0002580)1.62940200
166Cutaneous melanoma (HP:0012056)1.62924105
167Cafe-au-lait spot (HP:0000957)1.62594206
168Abnormality of T cell number (HP:0011839)1.62590011
169Recurrent cutaneous fungal infections (HP:0011370)1.61998526
170Stridor (HP:0010307)1.61374407
171Thoracic kyphosis (HP:0002942)1.61249814
172Cerebral aneurysm (HP:0004944)1.60585288
173Persistence of primary teeth (HP:0006335)1.60376278
174Fragile skin (HP:0001030)1.58825310
175Osteolytic defects of the phalanges of the hand (HP:0009771)1.58804431
176Osteolytic defects of the hand bones (HP:0009699)1.58804431
177Abnormality of the radial head (HP:0003995)1.57352741
178Myopathic facies (HP:0002058)1.56223472
179Thin bony cortex (HP:0002753)1.56130172
180Genu recurvatum (HP:0002816)1.55307474
181Premature ovarian failure (HP:0008209)1.54977233
182Gastrointestinal inflammation (HP:0004386)1.52422289
183Abnormality of the salivary glands (HP:0010286)1.52318257
184Mitral regurgitation (HP:0001653)1.51866019
185Renal cell carcinoma (HP:0005584)1.51582442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.48979634
2TRIB34.45665090
3CDK123.49316679
4CDC73.44987109
5PRPF4B2.97891495
6SRPK12.77553672
7EEF2K2.76486266
8MAP4K12.67690003
9TSSK62.20875816
10NME22.19422279
11SIK12.18624139
12MKNK12.01549612
13CLK12.01436311
14BUB11.96373082
15EPHA21.88221067
16STK101.85020280
17MAP3K101.83427348
18ZAK1.75517131
19RPS6KB21.75446429
20MKNK21.74911083
21NEK21.70106600
22CDK71.69612973
23TLK11.68360111
24ERN11.65300928
25TXK1.64865530
26MAP3K141.59850127
27CDK41.59613770
28WEE11.53854510
29BRD41.50835199
30FGFR41.47357450
31ATR1.44824223
32MST1R1.41901089
33PIM11.40720976
34TTK1.40016983
35STK161.38175493
36SCYL21.28453316
37IRAK31.27953424
38PLK11.24311201
39TAOK21.22104410
40JAK31.17271118
41CHEK11.17156523
42AURKB1.15429937
43RPS6KA41.14958908
44PASK1.14874869
45ERBB31.14630059
46MAPK111.14493502
47EIF2AK11.14172737
48STK41.13960563
49PKN21.12854178
50BTK1.10364804
51IKBKB1.09454518
52PLK41.09045062
53CHUK1.09043202
54TRPM71.05636075
55MAP3K130.99586954
56VRK10.96277683
57CDK60.94855591
58ALK0.93622253
59PIM20.92268296
60PDGFRA0.88469632
61YES10.88269078
62CAMK1D0.86259214
63IRAK20.85719363
64ATM0.84309173
65CDK20.84087645
66FLT30.84014052
67SIK30.83777669
68BMPR20.83681535
69DYRK30.82251950
70ZAP700.81197028
71MAP3K80.80783984
72CHEK20.79993355
73TEC0.79980405
74BMX0.77652892
75LATS20.76590625
76RPS6KA60.75753530
77PLK30.75192880
78ARAF0.74722774
79TESK20.74428700
80MTOR0.73362563
81EIF2AK30.73225951
82IRAK40.72106435
83BRAF0.71656510
84PTK60.70990264
85RIPK10.69445125
86ITK0.69018705
87RPS6KL10.68006236
88RPS6KC10.68006236
89VRK20.67536558
90KSR20.66325713
91EIF2AK20.66308751
92AURKA0.65789065
93CDK90.64671998
94MAP2K20.63550523
95MAP3K30.62953580
96PAK40.62242405
97BLK0.61775975
98CDC42BPA0.61087239
99MELK0.60125733
100NEK90.59797704
101RPS6KA50.59423712
102AKT20.58051923
103RPS6KA20.57714783
104TTN0.56712119
105MAP3K10.56418202
106NEK10.56261890
107ICK0.55984504
108CDK10.55428489
109CSNK2A20.54456590
110NLK0.54108557
111HIPK20.53943851
112KIT0.52172139
113PDPK10.51664645
114GRK60.50732398
115AKT30.50730881
116PRKD20.50513269
117TGFBR10.49736092
118MAPKAPK20.48888203
119PBK0.48812239
120TBK10.48779898
121PTK20.46731688
122TAOK10.46670484
123RPS6KA10.46450032
124PAK10.45822099
125RAF10.45725301
126KDR0.45656106
127MAP2K30.45345487
128CSNK2A10.44975274
129CSK0.44801590
130CSF1R0.43642263
131MAP3K90.43022916
132LRRK20.42635416
133LMTK20.42581130
134LCK0.42315172
135PAK20.42289644
136LYN0.42272235
137FGFR30.42232177
138CDK80.41809903
139RPS6KB10.41380777
140CAMK1G0.40516844
141MAP3K110.39880970
142PRKD30.39739761
143ILK0.37886929
144SIK20.37188899
145TAF10.35255559

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24949417
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41421325
3Mismatch repair_Homo sapiens_hsa034303.36470793
4One carbon pool by folate_Homo sapiens_hsa006703.14031719
5Base excision repair_Homo sapiens_hsa034103.11980388
6Spliceosome_Homo sapiens_hsa030403.05443266
7RNA polymerase_Homo sapiens_hsa030202.65962063
8RNA transport_Homo sapiens_hsa030132.60108149
9Homologous recombination_Homo sapiens_hsa034402.50659986
10Ribosome_Homo sapiens_hsa030102.45388347
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44953080
12Fanconi anemia pathway_Homo sapiens_hsa034602.36863804
13Nucleotide excision repair_Homo sapiens_hsa034202.34910517
14Cell cycle_Homo sapiens_hsa041102.00647112
15Pyrimidine metabolism_Homo sapiens_hsa002401.92906100
16mRNA surveillance pathway_Homo sapiens_hsa030151.90508367
17RNA degradation_Homo sapiens_hsa030181.83394122
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.83284245
19Primary immunodeficiency_Homo sapiens_hsa053401.81698029
20Non-homologous end-joining_Homo sapiens_hsa034501.80014200
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57137737
22Other glycan degradation_Homo sapiens_hsa005111.56960166
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.55698942
24Basal transcription factors_Homo sapiens_hsa030221.51781633
25p53 signaling pathway_Homo sapiens_hsa041151.43603605
26Proteasome_Homo sapiens_hsa030501.38261028
27Herpes simplex infection_Homo sapiens_hsa051681.34798758
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31342621
29Fructose and mannose metabolism_Homo sapiens_hsa000511.31304667
30Antigen processing and presentation_Homo sapiens_hsa046121.30949654
31Notch signaling pathway_Homo sapiens_hsa043301.27053151
32Epstein-Barr virus infection_Homo sapiens_hsa051691.25517107
33Endometrial cancer_Homo sapiens_hsa052131.17842872
34Measles_Homo sapiens_hsa051621.16579873
35Viral carcinogenesis_Homo sapiens_hsa052031.15714558
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15026580
37VEGF signaling pathway_Homo sapiens_hsa043701.12312029
38Small cell lung cancer_Homo sapiens_hsa052221.10691306
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08182137
40HTLV-I infection_Homo sapiens_hsa051661.05094931
41Acute myeloid leukemia_Homo sapiens_hsa052211.03489920
42Galactose metabolism_Homo sapiens_hsa000521.01910723
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00171392
44mTOR signaling pathway_Homo sapiens_hsa041500.96694214
45Purine metabolism_Homo sapiens_hsa002300.96585026
46Systemic lupus erythematosus_Homo sapiens_hsa053220.95333114
47Renal cell carcinoma_Homo sapiens_hsa052110.95092952
48MicroRNAs in cancer_Homo sapiens_hsa052060.94630689
49Apoptosis_Homo sapiens_hsa042100.93745369
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.93690111
51Vitamin B6 metabolism_Homo sapiens_hsa007500.93389139
52Chronic myeloid leukemia_Homo sapiens_hsa052200.92572016
53Glioma_Homo sapiens_hsa052140.91745288
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90724253
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.90111851
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.87138799
57Hepatitis C_Homo sapiens_hsa051600.86018438
58Carbon metabolism_Homo sapiens_hsa012000.85840470
59Insulin signaling pathway_Homo sapiens_hsa049100.85549886
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84264890
61Viral myocarditis_Homo sapiens_hsa054160.83787176
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81982207
63Legionellosis_Homo sapiens_hsa051340.81512841
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81094164
65B cell receptor signaling pathway_Homo sapiens_hsa046620.80467993
66N-Glycan biosynthesis_Homo sapiens_hsa005100.80433191
67Lysine degradation_Homo sapiens_hsa003100.79627955
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79146050
69ErbB signaling pathway_Homo sapiens_hsa040120.78866231
70Proteoglycans in cancer_Homo sapiens_hsa052050.74741231
71Hematopoietic cell lineage_Homo sapiens_hsa046400.74397174
72Hepatitis B_Homo sapiens_hsa051610.73426491
73Prion diseases_Homo sapiens_hsa050200.71953741
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68719405
75AMPK signaling pathway_Homo sapiens_hsa041520.68680020
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68516254
77Selenocompound metabolism_Homo sapiens_hsa004500.66521279
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66196593
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.65789781
80T cell receptor signaling pathway_Homo sapiens_hsa046600.65019874
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64262036
82Allograft rejection_Homo sapiens_hsa053300.62591785
83Inositol phosphate metabolism_Homo sapiens_hsa005620.61674276
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61467534
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60398122
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59844080
87Basal cell carcinoma_Homo sapiens_hsa052170.59455416
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58830822
89Thyroid cancer_Homo sapiens_hsa052160.57067062
90Influenza A_Homo sapiens_hsa051640.56519828
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.56216382
92Leishmaniasis_Homo sapiens_hsa051400.54766020
93Prolactin signaling pathway_Homo sapiens_hsa049170.54639561
94Focal adhesion_Homo sapiens_hsa045100.52979988
95Alcoholism_Homo sapiens_hsa050340.52514211
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.51886431
97Prostate cancer_Homo sapiens_hsa052150.50747436
98Insulin resistance_Homo sapiens_hsa049310.50624245
99Graft-versus-host disease_Homo sapiens_hsa053320.48993921
100Folate biosynthesis_Homo sapiens_hsa007900.48223663
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48178441
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48077742
103Shigellosis_Homo sapiens_hsa051310.47507086
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46943207
105Pathways in cancer_Homo sapiens_hsa052000.46200080
106Toxoplasmosis_Homo sapiens_hsa051450.43933188
107Colorectal cancer_Homo sapiens_hsa052100.43233815
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.42926591
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.41840474
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41323005
111Autoimmune thyroid disease_Homo sapiens_hsa053200.40317282
112Non-small cell lung cancer_Homo sapiens_hsa052230.37894366
113Biosynthesis of amino acids_Homo sapiens_hsa012300.37834499
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37625231
115Bladder cancer_Homo sapiens_hsa052190.36870372
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36680950
117Pancreatic cancer_Homo sapiens_hsa052120.35990820
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.35986483
119Adherens junction_Homo sapiens_hsa045200.35969090
120Hippo signaling pathway_Homo sapiens_hsa043900.35470930
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34649084
122HIF-1 signaling pathway_Homo sapiens_hsa040660.34542441
123TGF-beta signaling pathway_Homo sapiens_hsa043500.33093570
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32642909
125Osteoclast differentiation_Homo sapiens_hsa043800.31177956
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31173919
127Sulfur relay system_Homo sapiens_hsa041220.30715029
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28284511
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28131619
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27344774
131TNF signaling pathway_Homo sapiens_hsa046680.27177777
132Arachidonic acid metabolism_Homo sapiens_hsa005900.25345749
133Malaria_Homo sapiens_hsa051440.24641431
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24347317
135Pentose phosphate pathway_Homo sapiens_hsa000300.24340061
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24165063

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