DHX40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.88273893
2synaptonemal complex assembly (GO:0007130)5.93108493
3male meiosis (GO:0007140)5.65357627
4synaptonemal complex organization (GO:0070193)5.58366702
5nuclear pore organization (GO:0006999)5.47534887
6nuclear pore complex assembly (GO:0051292)5.29070394
7DNA methylation involved in gamete generation (GO:0043046)5.28438750
8cilium or flagellum-dependent cell motility (GO:0001539)4.76312908
9monoubiquitinated protein deubiquitination (GO:0035520)4.54112587
10chromosome organization involved in meiosis (GO:0070192)4.45440821
11mitotic sister chromatid cohesion (GO:0007064)4.36432458
12fusion of sperm to egg plasma membrane (GO:0007342)4.24812765
13acrosome assembly (GO:0001675)4.14839977
14meiotic nuclear division (GO:0007126)4.10347351
15sperm-egg recognition (GO:0035036)4.08458054
16pore complex assembly (GO:0046931)3.98563913
17gene silencing by RNA (GO:0031047)3.95660301
18intraciliary transport (GO:0042073)3.92045782
19binding of sperm to zona pellucida (GO:0007339)3.80125627
20male meiosis I (GO:0007141)3.78330957
21multicellular organism reproduction (GO:0032504)3.73122023
22cell wall macromolecule catabolic process (GO:0016998)3.69331732
23cell wall macromolecule metabolic process (GO:0044036)3.69331732
24cell-cell recognition (GO:0009988)3.64693018
25attachment of spindle microtubules to kinetochore (GO:0008608)3.55855761
26regulation of meiosis I (GO:0060631)3.55396820
27DNA unwinding involved in DNA replication (GO:0006268)3.53028173
28sperm motility (GO:0030317)3.48596387
29regulation of RNA export from nucleus (GO:0046831)3.47817175
30sister chromatid cohesion (GO:0007062)3.42445716
31mitotic chromosome condensation (GO:0007076)3.39349040
32DNA topological change (GO:0006265)3.37627683
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.34086092
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34086092
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34086092
36regulation of centriole replication (GO:0046599)3.32760405
37paraxial mesoderm development (GO:0048339)3.32039512
38sister chromatid segregation (GO:0000819)3.31193460
39meiotic cell cycle process (GO:1903046)3.26621144
40mitotic metaphase plate congression (GO:0007080)3.25348749
41meiotic chromosome segregation (GO:0045132)3.24360878
42spermatid development (GO:0007286)3.24093731
43DNA replication-dependent nucleosome assembly (GO:0006335)3.22885352
44DNA replication-dependent nucleosome organization (GO:0034723)3.22885352
45meiosis I (GO:0007127)3.21093985
46reproduction (GO:0000003)3.18577472
47regulation of histone H3-K9 methylation (GO:0051570)3.15801106
48histone H3-K9 methylation (GO:0051567)3.14767189
49metaphase plate congression (GO:0051310)3.09659665
50reciprocal meiotic recombination (GO:0007131)3.09488364
51reciprocal DNA recombination (GO:0035825)3.09488364
52Golgi transport vesicle coating (GO:0048200)3.05538345
53COPI coating of Golgi vesicle (GO:0048205)3.05538345
54genitalia morphogenesis (GO:0035112)3.04678605
55regulation of spindle organization (GO:0090224)3.03698044
56DNA alkylation (GO:0006305)3.03049320
57DNA methylation (GO:0006306)3.03049320
58gene silencing (GO:0016458)3.01264290
59kinetochore organization (GO:0051383)3.00104938
60cilium movement (GO:0003341)2.99484027
61mitotic nuclear envelope disassembly (GO:0007077)2.97580516
62meiotic cell cycle (GO:0051321)2.95823824
63regulation of centrosome cycle (GO:0046605)2.93199070
64mitotic sister chromatid segregation (GO:0000070)2.92428966
65resolution of meiotic recombination intermediates (GO:0000712)2.92262478
66apical protein localization (GO:0045176)2.91266158
67histone exchange (GO:0043486)2.91259206
68regulation of DNA endoreduplication (GO:0032875)2.89749228
69protein localization to chromosome, centromeric region (GO:0071459)2.87402058
70replicative senescence (GO:0090399)2.86260458
71DNA packaging (GO:0006323)2.85269358
72axonemal dynein complex assembly (GO:0070286)2.83884877
73histone H3-K9 modification (GO:0061647)2.81203797
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80701449
75nuclear envelope disassembly (GO:0051081)2.79878705
76membrane disassembly (GO:0030397)2.79878705
77regulation of mitotic spindle organization (GO:0060236)2.79088111
78microtubule depolymerization (GO:0007019)2.79066586
79negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.74814804
80chromosome condensation (GO:0030261)2.74153681
81macroautophagy (GO:0016236)2.73285085
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72833353
83neuronal stem cell maintenance (GO:0097150)2.72794904
84plasma membrane fusion (GO:0045026)2.69913819
85DNA synthesis involved in DNA repair (GO:0000731)2.69451353
86asymmetric protein localization (GO:0008105)2.68241329
87DNA ligation (GO:0006266)2.68111919
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.67588811
89regulation of chromosome segregation (GO:0051983)2.67214380
90positive regulation of chromosome segregation (GO:0051984)2.66411674
91non-recombinational repair (GO:0000726)2.66204405
92double-strand break repair via nonhomologous end joining (GO:0006303)2.66204405
93embryonic body morphogenesis (GO:0010172)2.65593149
94regulation of nucleobase-containing compound transport (GO:0032239)2.65377181
95centriole replication (GO:0007099)2.65098245
96CENP-A containing nucleosome assembly (GO:0034080)2.64962535
97epithelial cilium movement (GO:0003351)2.64137887
98protein localization to chromosome (GO:0034502)2.64126191
99left/right pattern formation (GO:0060972)2.62958850
100regulation of centrosome duplication (GO:0010824)2.62675635
101NLS-bearing protein import into nucleus (GO:0006607)2.62638011
102intestinal epithelial cell development (GO:0060576)2.62403545
103nonmotile primary cilium assembly (GO:0035058)2.62198837
104DNA replication-independent nucleosome assembly (GO:0006336)2.61555726
105DNA replication-independent nucleosome organization (GO:0034724)2.61555726
106synapsis (GO:0007129)2.61219019
107regulation of sister chromatid cohesion (GO:0007063)2.61194994
108protein localization to kinetochore (GO:0034501)2.59183954
109male gamete generation (GO:0048232)2.58641932
110spermatogenesis (GO:0007283)2.58579935
111establishment of chromosome localization (GO:0051303)2.58300170
112histone H3-K9 demethylation (GO:0033169)2.57320818
113establishment of planar polarity (GO:0001736)2.57249886
114establishment of tissue polarity (GO:0007164)2.57249886
115intra-S DNA damage checkpoint (GO:0031573)2.57073981
116chromatin remodeling at centromere (GO:0031055)2.56882112
117heterochromatin organization (GO:0070828)2.56733854
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56327362
119germ cell development (GO:0007281)2.56102365
120protein K6-linked ubiquitination (GO:0085020)2.52110761
121spindle checkpoint (GO:0031577)2.51623057
122histone H2A acetylation (GO:0043968)2.51476200
123dosage compensation (GO:0007549)2.51413062
124oocyte development (GO:0048599)2.50751040
125peptidyl-lysine dimethylation (GO:0018027)2.49330047
126ATP-dependent chromatin remodeling (GO:0043044)2.49099888
127cilium assembly (GO:0042384)2.48682955
128cilium organization (GO:0044782)2.47466931
129body morphogenesis (GO:0010171)2.46175069
130DNA duplex unwinding (GO:0032508)2.41419350
131DNA geometric change (GO:0032392)2.41184562
132establishment of integrated proviral latency (GO:0075713)2.40757350
133appendage development (GO:0048736)2.40396373
134limb development (GO:0060173)2.40396373
135negative regulation of DNA recombination (GO:0045910)2.39633518
136protein-DNA complex disassembly (GO:0032986)2.38131068
137nucleosome disassembly (GO:0006337)2.38131068
138cilium morphogenesis (GO:0060271)2.33084937
139histone H2B ubiquitination (GO:0033523)2.33062635
140lateral sprouting from an epithelium (GO:0060601)2.33013364
141regulation of translational fidelity (GO:0006450)2.32615761
142DNA conformation change (GO:0071103)2.32506317
143mitotic spindle organization (GO:0007052)2.32374155
144retinal ganglion cell axon guidance (GO:0031290)2.32021160
145negative regulation of oligodendrocyte differentiation (GO:0048715)2.29569425
146ectodermal placode formation (GO:0060788)2.28815349
147DNA strand elongation involved in DNA replication (GO:0006271)2.27159677
148negative regulation of DNA repair (GO:0045738)2.26772573
149olfactory bulb development (GO:0021772)2.26494730
150ventricular system development (GO:0021591)2.26426070
151establishment of nucleus localization (GO:0040023)2.26347296
152smoothened signaling pathway (GO:0007224)2.26221131
153pyrimidine nucleobase catabolic process (GO:0006208)2.22467784
154G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.21858080
155limb bud formation (GO:0060174)2.21358043
156DNA strand elongation (GO:0022616)2.19519365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30549295
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.36496688
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.69049128
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.94779887
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.94375159
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25642041
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09070466
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90290303
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.88122423
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80925104
11AR_21909140_ChIP-Seq_LNCAP_Human2.43188406
12FUS_26573619_Chip-Seq_HEK293_Human2.26551485
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92657688
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92559102
15* E2F1_21310950_ChIP-Seq_MCF-7_Human1.91678858
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88150711
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.88070578
18IGF1R_20145208_ChIP-Seq_DFB_Human1.87716971
19EWS_26573619_Chip-Seq_HEK293_Human1.87607532
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83268764
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76854997
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74929069
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69185020
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.64984318
25TAF15_26573619_Chip-Seq_HEK293_Human1.64227745
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60940651
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60194358
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58618025
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58485026
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.56938816
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.49775846
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49710707
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43636340
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42995229
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42995229
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42995229
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42271462
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40504435
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39465155
40* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39131953
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.37803505
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35879217
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32086066
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.31544745
45ELK1_19687146_ChIP-ChIP_HELA_Human1.28226420
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27131298
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27076282
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.23482289
49KDM5A_27292631_Chip-Seq_BREAST_Human1.22389820
50* TTF2_22483619_ChIP-Seq_HELA_Human1.20991798
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20844305
52XRN2_22483619_ChIP-Seq_HELA_Human1.20008364
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19019071
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18227921
55RNF2_27304074_Chip-Seq_NSC_Mouse1.17762167
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.17424143
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.16462810
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15521963
59SOX9_26525672_Chip-Seq_HEART_Mouse1.14443307
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13405000
61* VDR_23849224_ChIP-Seq_CD4+_Human1.12072172
62* DCP1A_22483619_ChIP-Seq_HELA_Human1.11715125
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11477403
64TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11041219
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10592141
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.10389046
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10185747
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10061590
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09489743
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09187211
71TFEB_21752829_ChIP-Seq_HELA_Human1.09097587
72CLOCK_20551151_ChIP-Seq_293T_Human1.09061278
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08833739
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07371976
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07172996
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06836326
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06689286
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06613679
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05063457
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04607134
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.04188338
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04167905
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03821335
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.03131649
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02837584
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01604784
87* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00739283
88* ER_23166858_ChIP-Seq_MCF-7_Human1.00713431
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99807898
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99200052
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99027441
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98166994
93* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98063155
94* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97611651
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97330087
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96556785
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.95407946
98EZH2_22144423_ChIP-Seq_EOC_Human0.94372260
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.94063062
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94011324
101BRD4_25478319_ChIP-Seq_HGPS_Human0.93863021
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93441375
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92690983
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92438206
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92165081
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91941382
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.91796642
108* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91576907
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91029051
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91010445
111* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90677767
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90154971
113MYC_18940864_ChIP-ChIP_HL60_Human0.89771363
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88866381
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88629345
116MYB_26560356_Chip-Seq_TH1_Human0.88461256
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88148688
118AHR_22903824_ChIP-Seq_MCF-7_Human0.87711995
119* LXR_22158963_ChIP-Seq_LIVER_Mouse0.87523458
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87457942
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87108305
122ZNF274_21170338_ChIP-Seq_K562_Hela0.86513953
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85893900
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83594584
125* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83481692
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83452434
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82934168
128IRF8_22096565_ChIP-ChIP_GC-B_Human0.82833104
129* FOXP3_21729870_ChIP-Seq_TREG_Human0.82381565
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82332715
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81415626
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.81214855
133* CDX2_22108803_ChIP-Seq_LS180_Human0.80746545
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79170043
135CHD1_26751641_Chip-Seq_LNCaP_Human0.76419205
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75672189
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75649822
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.75569822
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74589912
140GATA6_25053715_ChIP-Seq_YYC3_Human0.74573016
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.74023586
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73595696
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73203552
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73131567
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.73128621
146* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72745599
147FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71981119
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71840411
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71832289
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71265088
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71227907
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.69538519
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68956353
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68906297
155GABP_19822575_ChIP-Seq_HepG2_Human0.68741458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.18919941
2MP0003693_abnormal_embryo_hatching2.78365475
3MP0005410_abnormal_fertilization2.69905181
4MP0008058_abnormal_DNA_repair2.49719961
5MP0010094_abnormal_chromosome_stability2.48416590
6MP0008057_abnormal_DNA_replication2.46518111
7MP0001929_abnormal_gametogenesis2.34604177
8MP0002210_abnormal_sex_determination2.23032795
9MP0003111_abnormal_nucleus_morphology2.17853724
10MP0002653_abnormal_ependyma_morphology2.10914560
11MP0010307_abnormal_tumor_latency2.03625784
12MP0003077_abnormal_cell_cycle2.03181815
13MP0005076_abnormal_cell_differentiation2.01749377
14MP0010030_abnormal_orbit_morphology1.97424353
15MP0008007_abnormal_cellular_replicative1.97328302
16MP0000778_abnormal_nervous_system1.90020448
17MP0001145_abnormal_male_reproductive1.88446410
18MP0003698_abnormal_male_reproductive1.87033637
19MP0008789_abnormal_olfactory_epithelium1.72652504
20MP0003942_abnormal_urinary_system1.70314988
21MP0008932_abnormal_embryonic_tissue1.69388041
22MP0000653_abnormal_sex_gland1.67901322
23MP0000383_abnormal_hair_follicle1.65639097
24MP0003123_paternal_imprinting1.60365714
25MP0004957_abnormal_blastocyst_morpholog1.58650867
26MP0001286_abnormal_eye_development1.57846738
27MP0000534_abnormal_ureter_morphology1.57614826
28MP0005394_taste/olfaction_phenotype1.57496112
29MP0005499_abnormal_olfactory_system1.57496112
30MP0010352_gastrointestinal_tract_polyps1.56464124
31MP0003122_maternal_imprinting1.56447909
32MP0003890_abnormal_embryonic-extraembry1.55940806
33MP0006292_abnormal_olfactory_placode1.54644599
34MP0000569_abnormal_digit_pigmentation1.54633885
35MP0001529_abnormal_vocalization1.54327647
36MP0002233_abnormal_nose_morphology1.53821080
37MP0000049_abnormal_middle_ear1.53201865
38MP0002751_abnormal_autonomic_nervous1.51970084
39MP0010678_abnormal_skin_adnexa1.49111966
40MP0005257_abnormal_intraocular_pressure1.45174045
41MP0002009_preneoplasia1.44670635
42MP0005365_abnormal_bile_salt1.44242725
43MP0005187_abnormal_penis_morphology1.42344448
44MP0002139_abnormal_hepatobiliary_system1.40990272
45MP0003861_abnormal_nervous_system1.39545950
46MP0001849_ear_inflammation1.38143055
47MP0006054_spinal_hemorrhage1.38034206
48MP0003755_abnormal_palate_morphology1.36065805
49MP0001730_embryonic_growth_arrest1.31135221
50MP0009697_abnormal_copulation1.31036690
51MP0001346_abnormal_lacrimal_gland1.29081972
52MP0002138_abnormal_hepatobiliary_system1.27830562
53MP0005646_abnormal_pituitary_gland1.27063736
54MP0005670_abnormal_white_adipose1.26194998
55MP0003121_genomic_imprinting1.26136010
56MP0003136_yellow_coat_color1.25616403
57MP0002938_white_spotting1.24377448
58MP0003252_abnormal_bile_duct1.23262768
59MP0002282_abnormal_trachea_morphology1.23065929
60MP0003183_abnormal_peptide_metabolism1.22644510
61MP0003786_premature_aging1.21759381
62MP0002928_abnormal_bile_duct1.21590903
63MP0000631_abnormal_neuroendocrine_gland1.21336531
64MP0004133_heterotaxia1.21181914
65MP0000350_abnormal_cell_proliferation1.18224152
66MP0002877_abnormal_melanocyte_morpholog1.17099520
67MP0005391_vision/eye_phenotype1.16810344
68MP0009379_abnormal_foot_pigmentation1.16118205
69MP0008995_early_reproductive_senescence1.14127729
70MP0002638_abnormal_pupillary_reflex1.14029800
71MP0002277_abnormal_respiratory_mucosa1.13906301
72MP0003705_abnormal_hypodermis_morpholog1.13278434
73MP0002161_abnormal_fertility/fecundity1.12857828
74MP0005380_embryogenesis_phenotype1.11785605
75MP0001672_abnormal_embryogenesis/_devel1.11785605
76MP0003300_gastrointestinal_ulcer1.11035081
77MP0001299_abnormal_eye_distance/1.10673622
78MP0000647_abnormal_sebaceous_gland1.09881094
79MP0002249_abnormal_larynx_morphology1.09679217
80MP0002822_catalepsy1.09466004
81MP0005647_abnormal_sex_gland1.09364399
82MP0000427_abnormal_hair_cycle1.09214235
83MP0004197_abnormal_fetal_growth/weight/1.08583576
84MP0002234_abnormal_pharynx_morphology1.08496059
85MP0002116_abnormal_craniofacial_bone1.08450782
86MP0002084_abnormal_developmental_patter1.08100138
87MP0000371_diluted_coat_color1.07100949
88MP0005248_abnormal_Harderian_gland1.06321398
89MP0001119_abnormal_female_reproductive1.06199263
90MP0003984_embryonic_growth_retardation1.04965574
91MP0003787_abnormal_imprinting1.04929917
92MP0004264_abnormal_extraembryonic_tissu1.04891696
93MP0003385_abnormal_body_wall1.04541834
94MP0009672_abnormal_birth_weight1.04190855
95MP0002088_abnormal_embryonic_growth/wei1.04151744
96MP0000955_abnormal_spinal_cord1.03966501
97MP0005220_abnormal_exocrine_pancreas1.03301687
98MP0002102_abnormal_ear_morphology1.02678291
99MP0009703_decreased_birth_body1.02352922
100MP0005408_hypopigmentation1.01478659
101MP0002086_abnormal_extraembryonic_tissu1.00830251
102MP0005389_reproductive_system_phenotype0.99692295
103MP0002160_abnormal_reproductive_system0.99426871
104MP0003938_abnormal_ear_development0.99423770
105MP0002111_abnormal_tail_morphology0.99409376
106MP0003567_abnormal_fetal_cardiomyocyte0.97640982
107MP0008961_abnormal_basal_metabolism0.96803103
108MP0004808_abnormal_hematopoietic_stem0.94947045
109MP0002184_abnormal_innervation0.94573362
110MP0002085_abnormal_embryonic_tissue0.93895271
111MP0003315_abnormal_perineum_morphology0.91704883
112MP0002697_abnormal_eye_size0.91106143
113MP0000579_abnormal_nail_morphology0.90511878
114MP0001293_anophthalmia0.90309828
115MP0002081_perinatal_lethality0.90147323
116MP0000537_abnormal_urethra_morphology0.89898572
117MP0002152_abnormal_brain_morphology0.89028548
118MP0001697_abnormal_embryo_size0.88916077
119MP0002098_abnormal_vibrissa_morphology0.88706207
120MP0006072_abnormal_retinal_apoptosis0.87187110
121MP0001340_abnormal_eyelid_morphology0.87112941
122MP0005409_darkened_coat_color0.86762605
123MP0002132_abnormal_respiratory_system0.86060365
124MP0003119_abnormal_digestive_system0.85476748
125MP0003937_abnormal_limbs/digits/tail_de0.84781914
126MP0000566_synostosis0.84307202
127MP0008438_abnormal_cutaneous_collagen0.83945445
128MP0001944_abnormal_pancreas_morphology0.83387813
129MP0000432_abnormal_head_morphology0.83328541
130MP0002693_abnormal_pancreas_physiology0.83274304
131MP0009053_abnormal_anal_canal0.82969621
132MP0003115_abnormal_respiratory_system0.74722051
133MP0002080_prenatal_lethality0.73567039
134MP0005666_abnormal_adipose_tissue0.73492709
135MP0001915_intracranial_hemorrhage0.73231615
136MP0002166_altered_tumor_susceptibility0.73130755
137MP0004019_abnormal_vitamin_homeostasis0.71186053
138MP0002092_abnormal_eye_morphology0.70368495
139MP0003699_abnormal_female_reproductive0.69337696
140MP0002168_other_aberrant_phenotype0.68329702
141MP0002019_abnormal_tumor_incidence0.67283523
142MP0010234_abnormal_vibrissa_follicle0.66290652
143MP0003935_abnormal_craniofacial_develop0.66046017
144MP0003195_calcinosis0.65871598
145MP0000609_abnormal_liver_physiology0.65540156
146MP0005085_abnormal_gallbladder_physiolo0.65264744
147MP0002896_abnormal_bone_mineralization0.65261128
148MP0002163_abnormal_gland_morphology0.65119545
149MP0003936_abnormal_reproductive_system0.64954175
150MP0000428_abnormal_craniofacial_morphol0.64833526
151MP0003283_abnormal_digestive_organ0.64784715
152MP0003868_abnormal_feces_composition0.63635287
153MP0000627_abnormal_mammary_gland0.63127488
154MP0000733_abnormal_muscle_development0.62665172
155MP0001919_abnormal_reproductive_system0.62425405

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.50923041
2Azoospermia (HP:0000027)3.52328673
3Abnormal spermatogenesis (HP:0008669)3.49159987
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.36358092
5Absent/shortened dynein arms (HP:0200106)3.36358092
6Chronic bronchitis (HP:0004469)3.15490024
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78271037
8Chromsome breakage (HP:0040012)2.76265327
9Impulsivity (HP:0100710)2.71182473
10Abnormal respiratory motile cilium physiology (HP:0012261)2.66095731
11Ectopic kidney (HP:0000086)2.64961152
12Metaphyseal cupping (HP:0003021)2.64871277
13Rhinitis (HP:0012384)2.64131248
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50803181
15Short 4th metacarpal (HP:0010044)2.50803181
16Medulloblastoma (HP:0002885)2.45286586
17Papillary thyroid carcinoma (HP:0002895)2.45284573
18Cortical dysplasia (HP:0002539)2.36414898
19Abnormality of chromosome stability (HP:0003220)2.34647681
20Abnormal respiratory epithelium morphology (HP:0012253)2.28620840
21Abnormal respiratory motile cilium morphology (HP:0005938)2.28620840
22Fibular hypoplasia (HP:0003038)2.27857656
23Facial cleft (HP:0002006)2.25899721
24Tubulointerstitial nephritis (HP:0001970)2.20540168
25Increased nuchal translucency (HP:0010880)2.20111187
26Abnormality of the 4th metacarpal (HP:0010012)2.20093904
27Volvulus (HP:0002580)2.19801868
28Cutaneous finger syndactyly (HP:0010554)2.19590965
29Hyperglycemia (HP:0003074)2.18617062
30Abnormality of the anterior horn cell (HP:0006802)2.18239814
31Degeneration of anterior horn cells (HP:0002398)2.18239814
32Pancreatic fibrosis (HP:0100732)2.18179195
33Occipital encephalocele (HP:0002085)2.15675070
34True hermaphroditism (HP:0010459)2.14972675
35Abnormality of the renal cortex (HP:0011035)2.13388688
36Asymmetry of the thorax (HP:0001555)2.11405025
37Rhabdomyosarcoma (HP:0002859)2.10457500
38Hypoplastic labia majora (HP:0000059)2.09885147
39Colon cancer (HP:0003003)2.07613527
40Overlapping toe (HP:0001845)2.05387719
41Abnormal ciliary motility (HP:0012262)2.05323495
42Postaxial foot polydactyly (HP:0001830)2.04985721
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.04812463
44Abnormality of the fingertips (HP:0001211)2.04602774
45Broad distal phalanx of finger (HP:0009836)2.03291710
46Abnormal biliary tract morphology (HP:0012440)2.01614565
47Thyroid carcinoma (HP:0002890)2.00798583
48Pancreatic cysts (HP:0001737)2.00737108
49Bronchiectasis (HP:0002110)2.00409716
50Bronchitis (HP:0012387)2.00037287
51Nephroblastoma (Wilms tumor) (HP:0002667)1.96536007
52Small epiphyses (HP:0010585)1.95589610
53Preaxial hand polydactyly (HP:0001177)1.95005247
54Hypoglycemic seizures (HP:0002173)1.94825956
55Truncal obesity (HP:0001956)1.94701015
56High anterior hairline (HP:0009890)1.93113105
57Cutaneous syndactyly (HP:0012725)1.92334218
58Birth length less than 3rd percentile (HP:0003561)1.91395276
59Vertebral arch anomaly (HP:0008438)1.89090818
60Infertility (HP:0000789)1.89075420
61Coronal craniosynostosis (HP:0004440)1.87945018
62Recurrent sinusitis (HP:0011108)1.87621286
63Abnormality of the labia majora (HP:0012881)1.85523513
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.84864803
65Spinal muscular atrophy (HP:0007269)1.84620139
66Biliary tract neoplasm (HP:0100574)1.84565228
67Heterotopia (HP:0002282)1.83267423
68Embryonal renal neoplasm (HP:0011794)1.82622392
69Male infertility (HP:0003251)1.82514042
70Abnormality of the renal medulla (HP:0100957)1.82448246
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82333556
72Bifid tongue (HP:0010297)1.82005385
73Hyperinsulinemic hypoglycemia (HP:0000825)1.81765577
74Nephronophthisis (HP:0000090)1.81008038
75Postaxial hand polydactyly (HP:0001162)1.80902962
76Intellectual disability, moderate (HP:0002342)1.80712865
77Congenital primary aphakia (HP:0007707)1.80442806
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.80367460
79Tubular atrophy (HP:0000092)1.80067798
80Meckel diverticulum (HP:0002245)1.79875505
81Molar tooth sign on MRI (HP:0002419)1.79045053
82Abnormality of midbrain morphology (HP:0002418)1.79045053
83Absent frontal sinuses (HP:0002688)1.78131047
84Gonadotropin excess (HP:0000837)1.77963494
85Chronic hepatic failure (HP:0100626)1.77518350
86Upper motor neuron abnormality (HP:0002127)1.76897962
87Facial hemangioma (HP:0000329)1.76742108
88Carpal bone hypoplasia (HP:0001498)1.74900584
89Absent radius (HP:0003974)1.74228260
90Subacute progressive viral hepatitis (HP:0006572)1.73747425
91Triphalangeal thumb (HP:0001199)1.73045848
92Cystic liver disease (HP:0006706)1.72410769
93Breast carcinoma (HP:0003002)1.71450797
94Renal dysplasia (HP:0000110)1.70389917
95Astrocytoma (HP:0009592)1.69130442
96Abnormality of the astrocytes (HP:0100707)1.69130442
97Abnormality of the phalanges of the hallux (HP:0010057)1.69042078
98Oligodactyly (hands) (HP:0001180)1.68809022
99Small intestinal stenosis (HP:0012848)1.67750938
100Duodenal stenosis (HP:0100867)1.67750938
101Medial flaring of the eyebrow (HP:0010747)1.66904638
102Tubulointerstitial abnormality (HP:0001969)1.66544747
103Gait imbalance (HP:0002141)1.66258918
104Broad foot (HP:0001769)1.65024505
105Vaginal atresia (HP:0000148)1.64755988
106Rhizomelia (HP:0008905)1.64138586
107Genital tract atresia (HP:0001827)1.63641157
108Abnormality of the ileum (HP:0001549)1.63119790
109Cerebellar dysplasia (HP:0007033)1.63081595
110Short ribs (HP:0000773)1.63060566
111Supernumerary spleens (HP:0009799)1.62900170
112Abnormality of the preputium (HP:0100587)1.62803285
113Arteriovenous malformation (HP:0100026)1.62468053
114Long eyelashes (HP:0000527)1.62369030
115Abnormal lung lobation (HP:0002101)1.61986876
116Ependymoma (HP:0002888)1.61661035
117Hydroxyprolinuria (HP:0003080)1.61453639
118Abnormality of proline metabolism (HP:0010907)1.61453639
119Glioma (HP:0009733)1.61298395
12011 pairs of ribs (HP:0000878)1.61232019
121Poor coordination (HP:0002370)1.60717027
122Myocardial infarction (HP:0001658)1.60511157
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.60324723
124Deep philtrum (HP:0002002)1.60317715
125Abnormality of pyrimidine metabolism (HP:0004353)1.59618268
126Pheochromocytoma (HP:0002666)1.59437361
127Abnormality of the intrinsic pathway (HP:0010989)1.58522381
128Insulin-resistant diabetes mellitus (HP:0000831)1.58406893
129Short thorax (HP:0010306)1.58016639
130Abnormality of the labia minora (HP:0012880)1.57823466
131Absent forearm bone (HP:0003953)1.57425247
132Aplasia involving forearm bones (HP:0009822)1.57425247
133Hematochezia (HP:0002573)1.57268904
134Neoplasm of striated muscle (HP:0009728)1.57258015
135Abnormality of chloride homeostasis (HP:0011422)1.57218103
136Sloping forehead (HP:0000340)1.55717779
137Short humerus (HP:0005792)1.55692978
138Abnormality of the nasal septum (HP:0000419)1.55374274
139Broad finger (HP:0001500)1.55162687
140Micropenis (HP:0000054)1.54129838
141Abnormality of the duodenum (HP:0002246)1.54061277
142Nephrogenic diabetes insipidus (HP:0009806)1.53627461
143Missing ribs (HP:0000921)1.53456823
144Abnormality of the lower motor neuron (HP:0002366)1.53450796
145Bifid scrotum (HP:0000048)1.52963979
146Duplication of thumb phalanx (HP:0009942)1.52953283
147Renal hypoplasia (HP:0000089)1.52533900
148Median cleft lip (HP:0000161)1.52439686
149Hypoplastic ischia (HP:0003175)1.52056875
150Oligodactyly (HP:0012165)1.51700962
151Intestinal atresia (HP:0011100)1.51552107
152Recurrent otitis media (HP:0000403)1.51428006
153Flattened epiphyses (HP:0003071)1.51098584
154Microglossia (HP:0000171)1.50915959
155Hypoglycemic coma (HP:0001325)1.50561130
156Enlarged kidneys (HP:0000105)1.49608975
157Abnormality of the carotid arteries (HP:0005344)1.48103279
158Aplasia/hypoplasia of the humerus (HP:0006507)1.47299699
159Symptomatic seizures (HP:0011145)1.47040060
160Osteomalacia (HP:0002749)1.45370769
161Deviation of the thumb (HP:0009603)1.44845555
162Abnormal foot bone ossification (HP:0010675)1.44629558
163Congenital hepatic fibrosis (HP:0002612)1.43986615
164Conjunctival telangiectasia (HP:0000524)1.43953779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.71986138
2PNCK3.24923489
3PDK33.09344733
4PDK43.09344733
5ACVR1B2.81934625
6LATS12.74516652
7CDC72.65463599
8PDK22.46028018
9STK38L2.43225838
10NEK22.29941950
11FRK2.17969201
12PASK2.13985691
13CCNB12.11488202
14STK32.04210332
15CASK1.96821655
16BRD41.95598676
17SRPK11.92250944
18INSRR1.82600438
19WEE11.79886499
20BRSK21.78551093
21AKT31.69548074
22TTK1.69107815
23ZAK1.67085504
24MAP3K41.63786298
25PLK41.57964749
26PBK1.53313557
27PKN21.52166256
28DYRK31.51757966
29RPS6KA41.50686681
30TAF11.50233296
31NUAK11.46273595
32TRIM281.43853258
33ATR1.35515682
34NEK91.34654229
35EPHB21.31848566
36KSR11.30414148
37PLK11.22222445
38MAP3K101.20882229
39MAP2K71.19429796
40EIF2AK31.19129269
41TAOK31.18810721
42CHEK11.17549540
43EPHA21.17541573
44PRKD31.16825191
45EEF2K1.16562249
46IRAK31.16307478
47CDK61.15095099
48STK391.14850033
49MKNK21.10385737
50CHEK21.09495262
51PLK31.08484962
52NEK61.07680380
53TSSK61.06185193
54MELK1.05919945
55NTRK11.03578358
56STK101.02804967
57ATM1.02463849
58EIF2AK11.00871628
59MAPK151.00829632
60EPHA31.00796494
61MARK30.98701175
62CSNK1G20.98076730
63AURKB0.97598697
64CSNK1A1L0.97547823
65MET0.95738306
66CSNK1G10.95202425
67PLK20.94740600
68CDK90.94559812
69CSNK1G30.94014218
70CDK70.92793868
71CHUK0.91754572
72DYRK1B0.91507146
73CDK40.91461828
74NTRK20.90477797
75EPHA40.90091890
76FGFR40.89930401
77BUB10.88958199
78STK40.88287820
79MTOR0.83918897
80ICK0.83408862
81CDK80.81352355
82RPS6KB20.81089829
83RPS6KB10.80841658
84CAMK1D0.80805477
85TESK10.79657084
86PIM10.79459205
87PTK60.78491768
88MAP3K140.75723038
89CAMK1G0.75525610
90FGFR30.73891138
91TNIK0.73065917
92WNK30.70003033
93BRSK10.69672952
94PDGFRA0.69119209
95MKNK10.68514264
96CDK30.68085154
97MST40.67009106
98PIK3CA0.65640623
99IRAK10.62769837
100KSR20.61967009
101WNK40.61831012
102RAF10.61319320
103NEK10.58595521
104WNK10.57997298
105CDK20.57852052
106ERBB30.56369747
107SGK20.56102550
108SCYL20.53261626
109YES10.51804986
110PDGFRB0.51755780
111CDK10.51602110
112FLT30.51441655
113CSNK1E0.51269384
114STK160.49155652
115AURKA0.49017021
116NME10.47581247
117AKT20.46578967
118CDK180.46571664
119DYRK20.45816658
120JAK30.45336905
121PRKDC0.44916568
122TEC0.44878000
123ERN10.44662713
124RET0.44657798
125ERBB20.44465005
126BCR0.43888629
127CSK0.43422881
128JAK10.43342818
129PAK40.42885063
130FGFR10.42641130
131RPS6KA50.42590605
132CDK150.41696767
133SIK10.41625746
134BRAF0.41566354
135FGFR20.41440932
136SGK30.40895475
137ITK0.40878654
138EIF2AK20.40501881
139MAPK110.39435764
140TGFBR20.38843420
141MAPK140.38396801
142STK380.38365321
143PRKAA10.37662184
144MAP3K30.37320920
145ZAP700.36610249
146ERBB40.36180332
147TYK20.36135616

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.69139699
2Basal transcription factors_Homo sapiens_hsa030222.59357009
3Vitamin B6 metabolism_Homo sapiens_hsa007502.48168868
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43671115
5RNA transport_Homo sapiens_hsa030132.29594483
6Selenocompound metabolism_Homo sapiens_hsa004502.28273013
7Fanconi anemia pathway_Homo sapiens_hsa034602.21176365
8Cell cycle_Homo sapiens_hsa041102.20635600
9Hedgehog signaling pathway_Homo sapiens_hsa043402.15174541
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11391042
11Non-homologous end-joining_Homo sapiens_hsa034501.99490983
12One carbon pool by folate_Homo sapiens_hsa006701.96576425
13mRNA surveillance pathway_Homo sapiens_hsa030151.95194607
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85083169
15Homologous recombination_Homo sapiens_hsa034401.79880189
16Lysine degradation_Homo sapiens_hsa003101.71700604
17Steroid biosynthesis_Homo sapiens_hsa001001.70299934
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46710951
19p53 signaling pathway_Homo sapiens_hsa041151.45899300
20Thyroid cancer_Homo sapiens_hsa052161.45889720
21Protein export_Homo sapiens_hsa030601.44658642
22Spliceosome_Homo sapiens_hsa030401.44214818
23Systemic lupus erythematosus_Homo sapiens_hsa053221.40470728
24Mismatch repair_Homo sapiens_hsa034301.40124289
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39183145
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.38207702
27Herpes simplex infection_Homo sapiens_hsa051681.31354951
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27554799
29DNA replication_Homo sapiens_hsa030301.27197073
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24563688
31Endometrial cancer_Homo sapiens_hsa052131.24415066
32RNA degradation_Homo sapiens_hsa030181.23957691
33Staphylococcus aureus infection_Homo sapiens_hsa051501.22423182
34Axon guidance_Homo sapiens_hsa043601.22137702
35Colorectal cancer_Homo sapiens_hsa052101.21482989
36Wnt signaling pathway_Homo sapiens_hsa043101.21245252
37Notch signaling pathway_Homo sapiens_hsa043301.19916964
38Antigen processing and presentation_Homo sapiens_hsa046121.19386342
39Viral carcinogenesis_Homo sapiens_hsa052031.17678426
40Adherens junction_Homo sapiens_hsa045201.15339674
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14768792
42Base excision repair_Homo sapiens_hsa034101.12490093
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11193848
44Alcoholism_Homo sapiens_hsa050341.09895480
45Legionellosis_Homo sapiens_hsa051341.08235546
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07023226
47Vitamin digestion and absorption_Homo sapiens_hsa049771.05699795
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05485588
49Prostate cancer_Homo sapiens_hsa052151.04500818
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.00256605
51Small cell lung cancer_Homo sapiens_hsa052221.00040171
52Complement and coagulation cascades_Homo sapiens_hsa046100.95608118
53Sulfur metabolism_Homo sapiens_hsa009200.95475789
54Epstein-Barr virus infection_Homo sapiens_hsa051690.94231248
55Tight junction_Homo sapiens_hsa045300.93576757
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.93427435
57MicroRNAs in cancer_Homo sapiens_hsa052060.93064995
58Melanogenesis_Homo sapiens_hsa049160.92088276
59Nucleotide excision repair_Homo sapiens_hsa034200.89885618
60HTLV-I infection_Homo sapiens_hsa051660.88666152
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84491905
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84490858
63Influenza A_Homo sapiens_hsa051640.82347260
64Ribosome_Homo sapiens_hsa030100.81744078
65FoxO signaling pathway_Homo sapiens_hsa040680.81314932
66Melanoma_Homo sapiens_hsa052180.81086317
67Insulin resistance_Homo sapiens_hsa049310.79179350
68ErbB signaling pathway_Homo sapiens_hsa040120.78601310
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78123574
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76477228
71Propanoate metabolism_Homo sapiens_hsa006400.75157042
72TGF-beta signaling pathway_Homo sapiens_hsa043500.74523309
73Renin-angiotensin system_Homo sapiens_hsa046140.73622599
74Measles_Homo sapiens_hsa051620.71876908
75Glioma_Homo sapiens_hsa052140.71424605
76Hippo signaling pathway_Homo sapiens_hsa043900.69311841
77AMPK signaling pathway_Homo sapiens_hsa041520.68614036
78Proteoglycans in cancer_Homo sapiens_hsa052050.68303995
79Pyrimidine metabolism_Homo sapiens_hsa002400.68125369
80Pathways in cancer_Homo sapiens_hsa052000.67928383
81Bladder cancer_Homo sapiens_hsa052190.66286658
82Tryptophan metabolism_Homo sapiens_hsa003800.66052437
83Non-small cell lung cancer_Homo sapiens_hsa052230.65986129
84Glucagon signaling pathway_Homo sapiens_hsa049220.65774673
85Renal cell carcinoma_Homo sapiens_hsa052110.65759213
86Circadian rhythm_Homo sapiens_hsa047100.63405801
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63226283
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60850726
89Fatty acid degradation_Homo sapiens_hsa000710.60827270
90Folate biosynthesis_Homo sapiens_hsa007900.59532748
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59203443
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59037761
93TNF signaling pathway_Homo sapiens_hsa046680.58801418
94Pentose phosphate pathway_Homo sapiens_hsa000300.58711820
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.58465548
96Choline metabolism in cancer_Homo sapiens_hsa052310.58360906
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.57480493
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57398461
99Gap junction_Homo sapiens_hsa045400.56952943
100Basal cell carcinoma_Homo sapiens_hsa052170.56463873
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55887080
102Carbon metabolism_Homo sapiens_hsa012000.55328139
103Oocyte meiosis_Homo sapiens_hsa041140.54954069
104N-Glycan biosynthesis_Homo sapiens_hsa005100.54717497
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54227778
106Cocaine addiction_Homo sapiens_hsa050300.53907476
107PPAR signaling pathway_Homo sapiens_hsa033200.53455262
108Fatty acid metabolism_Homo sapiens_hsa012120.52971909
109Inositol phosphate metabolism_Homo sapiens_hsa005620.52386608
110Hepatitis B_Homo sapiens_hsa051610.51503842
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50860683
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50658347
113Osteoclast differentiation_Homo sapiens_hsa043800.49580118
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46046285
115Apoptosis_Homo sapiens_hsa042100.46040267
116RNA polymerase_Homo sapiens_hsa030200.45844293
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44367764
118Glycerolipid metabolism_Homo sapiens_hsa005610.43793681
119Estrogen signaling pathway_Homo sapiens_hsa049150.43257390
120Chronic myeloid leukemia_Homo sapiens_hsa052200.42854657
121Dorso-ventral axis formation_Homo sapiens_hsa043200.41916648
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41522821
123Pancreatic cancer_Homo sapiens_hsa052120.41244769
124Toxoplasmosis_Homo sapiens_hsa051450.41113040
125ABC transporters_Homo sapiens_hsa020100.41021348
126Fat digestion and absorption_Homo sapiens_hsa049750.40292499
127Prolactin signaling pathway_Homo sapiens_hsa049170.39668162
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39537800
129mTOR signaling pathway_Homo sapiens_hsa041500.38893293
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38687674
131Type II diabetes mellitus_Homo sapiens_hsa049300.38320586
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37968181
133Regulation of autophagy_Homo sapiens_hsa041400.37494775
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36850042
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36657833
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.36233615
137Insulin signaling pathway_Homo sapiens_hsa049100.35954254
138Mineral absorption_Homo sapiens_hsa049780.35681513
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.35680145
140Biosynthesis of amino acids_Homo sapiens_hsa012300.35557423
141Purine metabolism_Homo sapiens_hsa002300.35381766
142Pyruvate metabolism_Homo sapiens_hsa006200.35350302
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34450459
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32910955
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.31115823
146Huntingtons disease_Homo sapiens_hsa050160.30992707

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »